Hub : Genes

Cox8a

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 PL mRNA stability Cox8a 0.07 0.04 4.6e-07 0.04 0.06 0.05 0.06 4.0e-05 1.1e-06 2.9e-06 4.4e-07
2 pVTA mRNA stability Cox8a 0.08 0.05 2.9e-05 0.04 0.04 0.03 0.03 7.9e-04 3.1e-04 1.7e-03 8.4e-04
3 Brain gene expression Cox8a 0.06 0.04 9.7e-06 0.04 0.04 0.05 0.05 3.3e-04 6.0e-05 1.6e-05 2.8e-05
4 pVTA gene expression Cox8a 0.11 0.07 2.9e-06 0.06 0.08 0.06 0.06 7.7e-06 1.0e-06 6.1e-06 6.5e-06
5 Liver gene expression Cox8a 0.11 0.06 7.7e-08 0.06 0.05 0.05 0.06 1.4e-07 4.4e-06 1.3e-06 4.6e-07
6 Adipose gene expression Cox8a 0.07 0.04 3.9e-05 0.04 0.03 0.02 0.03 7.6e-05 1.0e-04 5.8e-03 2.6e-04
7 NAcc gene expression Cox8a 0.06 0.03 7.9e-08 0.06 0.05 0.06 0.06 1.4e-09 1.5e-08 9.9e-09 5.4e-09
8 IC gene expression Cox8a 0.2 0.12 2.9e-04 0.01 0.02 0.04 0.02 1.4e-01 4.1e-02 1.3e-02 3.7e-02
9 Adipose mRNA stability Cox8a 0.04 0.03 5.7e-04 0 0.02 0.01 0.01 1.3e-01 5.7e-03 1.0e-02 2.8e-02
10 NAcc mRNA stability Cox8a 0.03 0.02 5.0e-05 0.01 0.02 0.01 0.01 6.1e-03 7.1e-04 4.2e-03 3.1e-03
11 Brain mRNA stability Cox8a 0.12 0.06 1.4e-09 0.1 0.1 0.11 0.1 3.9e-09 3.6e-09 3.0e-10 2.5e-09

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11
Bone: apparent density0.61.03.10.91.00.30.41.00.90.8-0.01.71.41.2
Area under the delay curve0.30.41.60.20.10.30.10.40.70.7-0.20.70.91.3
BMI with tail2.38.025.52.43.2-0.20.21.71.71.9-1.35.04.44.0
BMI without tail0.72.17.11.71.5-0.4-0.50.20.20.3-1.42.32.71.7
Body weight1.98.523.03.74.1-1.9-1.60.0-0.40.1-2.84.84.62.2
Weight adjusted by age0.91.42.71.51.6-1.4-1.3-1.3-0.6-1.1-0.81.21.1-0.6
Bone surface2.13.912.13.03.4-0.7-0.70.40.30.1-0.63.52.80.9
Bone volume1.11.96.61.72.20.10.31.00.90.80.22.61.71.1
Breakpoint value in progressive ratio session1.82.25.12.22.3-1.5-1.5-1.1-1.6-1.3-1.01.31.3-0.2
Number of licking bursts0.10.10.40.60.6-0.3-0.4-0.3-0.1-0.4-0.10.40.40.1
Context. condit. distance diff. score0.70.91.8-1.4-1.31.11.10.91.01.10.6-0.4-0.40.7
Locomotion velocity, session 10.10.20.70.0-0.20.20.20.20.20.3-0.20.30.70.8
Locomotion distance, session 10.60.82.30.50.40.30.30.80.70.8-0.41.31.41.5
Locomotion velocity, session 21.41.63.11.71.8-1.2-1.0-0.5-0.4-0.4-1.31.71.80.9
Locomotion distance, session 20.20.31.40.60.4-0.2-0.30.1-0.10.1-0.60.81.20.7
Locomotion velocity, session 32.02.34.8-0.8-0.41.21.62.11.92.20.31.51.02.0
Locomotion distance, session 30.10.10.3-0.1-0.10.10.20.40.30.5-0.20.40.40.5
Stereotopy head waving bouts, day 32.12.54.5-1.2-0.91.71.72.12.12.00.70.90.72.1
Stereotopy head waving duration, day 31.01.22.0-1.2-0.91.31.41.41.41.40.80.1-0.11.1
Locomotion velocity, session 71.31.43.0-0.9-0.61.31.41.71.41.60.70.60.31.6
Locomotion distance, session 70.30.30.7-0.4-0.40.50.40.70.60.6-0.20.60.80.8
Stereotopy head waving bouts, day 70.40.40.9-0.00.40.50.80.90.90.90.60.60.00.7
Stereotopy head waving duration, day 70.40.52.01.01.4-0.5-0.20.10.00.1-0.31.10.50.6
Locomotion velocity, session 80.30.41.51.10.5-0.4-0.6-0.5-0.4-0.6-0.60.41.20.2
Locomotion distance, session 81.01.42.7-0.5-0.61.41.41.61.51.60.90.70.71.5
Degree of sensitization distance0.60.61.4-0.3-0.10.70.60.90.90.90.10.80.81.2
Degree of sensitization stereotypy0.30.31.40.81.2-0.30.10.30.30.30.10.90.30.5
Conditioned locomotion0.70.81.81.31.1-1.0-0.9-0.6-0.4-0.6-1.01.01.3-0.2
Cocaine response after cond. corrected0.81.02.4-1.6-1.51.21.00.90.91.10.4-0.5-0.20.8
Cocaine response after cond. not corrected0.60.71.5-1.2-1.11.10.90.90.71.00.3-0.2-0.10.9
Cocaine response before conditioning0.50.61.71.21.3-0.8-0.8-0.7-1.0-0.8-0.30.50.2-0.2
Saline control response3.34.46.52.52.5-2.3-2.4-1.8-1.7-2.0-2.51.82.1-0.6
Bone: connectivity density1.42.26.62.12.2-0.6-0.60.30.20.0-0.92.62.30.9
Bone: cortical apparent density0.81.12.20.30.2-1.1-1.1-1.3-1.3-1.4-0.7-0.9-0.6-1.5
Bone: cortical area0.40.72.01.11.4-0.7-0.6-0.1-0.1-0.2-0.61.40.90.4
Bone: cortical porosity0.10.10.40.30.1-0.2-0.3-0.4-0.6-0.5-0.0-0.4-0.2-0.4
Bone: cortical porosity0.30.30.60.80.6-0.5-0.6-0.6-0.8-0.6-0.40.00.3-0.4
Bone: cortical thickness3.45.69.22.32.1-2.9-3.0-2.6-2.8-2.8-2.80.61.2-1.5
Bone: cortical thickness0.81.02.30.70.4-1.1-1.3-1.0-1.2-1.1-1.50.10.8-0.7
Bone: cortical tissue density1.01.32.50.50.3-1.3-1.3-1.4-1.4-1.5-0.9-0.8-0.5-1.6
Condit. Reinf. active minus inactive responses0.30.40.80.40.6-0.9-0.6-0.5-0.5-0.3-0.80.40.3-0.8
Condit. Reinf. active-inactive response ratio0.50.62.10.30.3-0.9-0.7-0.9-0.8-0.7-0.6-0.4-0.3-1.4
Condit. Reinf. active responses0.10.10.40.10.4-0.30.10.20.20.4-0.30.60.2-0.1
Condit. Reinf. inactive responses0.81.01.8-0.4-0.11.01.11.31.31.30.70.70.21.3
Incentive salience index mean0.30.41.00.60.9-0.7-0.4-0.1-0.20.0-0.81.00.8-0.2
Condit. Reinf. lever presses0.40.52.10.71.1-0.2-0.10.50.20.4-0.31.41.00.5
Condit. Reinf. active minus inactive responses0.30.30.8-0.3-0.10.70.80.80.60.70.9-0.0-0.6-0.1
Condit. Reinf. active-inactive response ratio1.92.24.4-0.9-0.51.72.02.01.82.11.80.2-0.90.6
Condit. Reinf. active responses0.00.10.30.30.5-0.2-0.10.1-0.1-0.10.10.3-0.1-0.4
Condit. Reinf. inactive responses1.01.22.61.00.7-1.2-1.5-1.2-1.4-1.6-1.20.10.7-0.7
Condit. Reinf. lever presses0.71.03.81.61.9-0.5-0.50.2-0.2-0.3-0.21.71.20.3
Condit. Reinf. lever reinforcers received0.10.20.70.70.8-0.4-0.4-0.2-0.3-0.4-0.10.40.1-0.5
Conditioned reinforcement - actives0.30.52.3-0.00.30.80.90.80.70.41.50.2-0.60.8
Conditioned reinforcement - inactives1.62.44.0-2.0-0.91.51.81.61.71.52.0-0.4-1.71.3
Conditioned locomotion4.76.212.4-3.5-2.92.72.62.12.12.02.7-1.9-2.81.1
Patch foraging indifference point 0 sec0.00.00.1-0.10.2-0.3-0.2-0.1-0.4-0.1-0.40.2-0.10.0
Patch foraging indifference point AUC1.42.04.72.22.2-1.8-1.5-1.4-0.9-1.3-0.91.10.8-0.8
Delay disc. indifference point, 0s delay1.11.23.8-0.2-0.51.10.91.31.51.20.30.71.11.9
Delay disc. indifference point, 16s delay0.30.30.7-0.7-0.30.50.50.70.80.80.40.1-0.50.7
Delay disc. indifference point, 2s delay0.80.92.7-0.1-0.21.00.91.11.61.30.60.70.61.2
Delay disc. indifference point, 24s delay0.20.20.60.0-0.0-0.5-0.7-0.7-0.2-0.4-0.8-0.00.3-0.1
Delay disc. indifference point, 4s delay0.30.31.50.1-0.0-0.0-0.20.10.20.4-0.80.61.01.2
Delay disc. indifference point, 8s delay0.10.10.50.1-0.30.40.10.20.30.3-0.10.10.70.6
Indifference point function ln k3.35.714.1-3.6-3.82.82.42.11.71.91.6-2.1-1.71.0
Indifference point function log k3.35.714.1-3.6-3.82.82.42.11.71.91.6-2.1-1.71.0
Patch foraging total patch changes 0 sec0.10.30.70.00.2-0.6-0.6-0.6-0.8-0.6-0.7-0.0-0.1-0.2
Patch foraging total patch changes 12 sec3.64.78.82.83.0-2.6-2.3-1.7-2.1-1.9-2.22.01.8-0.0
Patch foraging total patch changes 18 sec0.60.81.91.41.3-1.1-0.9-0.8-0.8-0.8-0.70.70.4-0.7
Patch foraging total patch changes 24 sec2.13.66.71.92.5-2.6-2.2-1.8-1.5-1.5-2.31.81.4-0.1
Patch foraging total patch changes 6 sec0.71.12.01.21.4-1.1-1.1-0.7-0.6-0.7-1.41.31.4-0.1
Patch foraging time to switch 0 sec0.81.64.81.51.50.30.20.81.00.90.22.21.81.5
Patch foraging water rate 0 sec1.12.47.1-2.7-2.30.60.60.0-0.2-0.20.6-2.4-2.5-1.0
Patch foraging water rate 12 sec2.34.816.5-4.1-3.61.31.20.40.40.60.7-3.2-2.9-0.6
Patch foraging water rate 18 sec1.01.56.1-2.5-2.11.10.80.70.40.50.2-1.3-1.10.5
Patch foraging water rate 24 sec1.52.17.0-2.7-2.31.21.00.40.50.60.8-1.9-1.7-0.0
Patch foraging water rate 6 sec1.52.27.6-2.8-2.70.80.60.1-0.00.30.0-2.3-1.8-0.4
Seeking ratio, delayed vs. immediate footshock0.10.10.4-0.6-0.3-0.00.10.1-0.10.3-0.3-0.1-0.30.1
Distance traveled before self-admin0.50.72.41.11.5-0.5-0.10.30.00.3-0.31.50.70.6
Distance traveled after self-admin0.50.61.20.50.7-1.0-0.8-1.0-1.1-0.9-0.5-0.1-0.3-0.5
Extensor digitorum longus weight4.417.334.25.75.8-4.4-4.0-2.5-2.5-2.5-4.44.95.10.8
Bone: elastic displacement0.70.82.5-1.0-1.3-0.2-0.3-0.8-0.7-0.6-0.4-1.6-1.0-0.4
Bone: elastic work1.31.74.11.00.8-1.5-1.7-1.4-1.4-1.4-2.00.51.20.4
Bone: endosteal estimation2.86.111.4-1.3-0.92.82.93.23.43.32.11.40.72.9
Bone: endosteal perimeter3.67.814.4-1.5-1.03.33.53.73.83.72.91.30.22.6
Epididymis fat weight2.38.012.8-3.2-2.33.23.63.52.73.62.9-0.5-2.12.0
Delta time in closed arm before/after self-admin0.70.73.10.3-0.0-0.6-0.9-0.4-1.0-0.5-1.80.40.90.8
Delta time in open arm before/after self-admin0.40.41.80.71.4-0.8-0.4-0.4-0.2-0.40.10.80.0-0.7
Diff in mean of infusions in LGA sessions1.01.23.81.01.1-1.3-1.2-0.7-2.0-0.9-1.30.50.5-0.6
Delay discount exponential model param0.30.31.3-0.3-0.2-0.20.1-0.2-0.6-0.50.3-0.7-0.9-1.2
Extinction: sum of active levers before priming1.51.74.01.82.0-1.5-1.1-0.6-0.8-0.4-1.21.71.50.2
Active lever presses in extinction session 61.81.75.22.12.3-1.3-1.0-0.6-1.0-0.7-0.71.61.2-0.4
Bone: final force1.42.25.72.02.2-0.9-0.8-0.1-0.0-0.2-1.02.42.11.5
Bone: final moment1.42.25.62.02.2-0.9-0.8-0.1-0.1-0.2-1.12.42.11.6
Food consumed during 24 hour testing period0.10.20.40.20.4-0.4-0.4-0.60.0-0.60.1-0.1-0.5-0.6
Glucose3.04.77.2-2.0-2.02.72.62.62.62.72.0-0.0-0.32.3
Heart weight1.52.35.3-1.0-1.01.51.62.01.92.30.30.81.01.8
Delay discount hyperbolic model param0.40.41.6-0.3-0.1-0.3-0.1-0.4-0.8-0.70.2-0.7-0.9-1.3
Intermittent access intake day 1-15 change0.61.22.9-1.2-0.91.11.10.70.90.21.7-1.1-1.7-0.3
Intermittent access intake escalation0.61.23.3-1.0-0.81.11.10.70.90.21.8-1.0-1.7-0.4
Intermittent access intake escalation 20.70.82.3-1.0-0.60.81.00.70.60.41.4-0.7-1.5-0.4
Intermitt. access day 1 inactive lever presses0.10.40.9-0.4-0.60.50.50.10.5-0.01.0-0.8-0.9-0.6
Intermitt. access day 15 inactive lever presses1.22.45.1-1.7-0.71.41.92.31.62.21.40.2-1.31.1
Intermitt. access escalation Index1.01.44.0-2.0-1.81.00.90.70.40.50.6-1.5-1.4-0.1
Intermittent access day 1 total infusions5.08.016.3-2.0-1.53.23.34.03.93.62.41.0-0.03.0
Intermittent access day 15 total infusions5.88.714.1-2.8-2.23.53.73.83.63.13.6-0.5-1.81.9
Intermittent access terminal intake (last 3 days)6.78.817.2-2.5-1.63.43.74.23.83.53.20.5-1.12.6
Intermittent access total infusions7.08.216.0-2.3-1.73.33.54.03.83.42.90.5-0.72.8
Intermittent access day 1 locomotion3.44.38.9-1.6-1.22.32.43.02.72.71.60.7-0.22.3
Intermittent access day 15 total locomotion3.36.011.6-2.4-1.42.83.13.42.82.82.90.1-1.51.9
Intermittent access total locomotion8.810.520.2-2.9-1.73.64.04.54.14.13.30.6-1.33.0
Intermittent access standard deviation0.61.32.1-1.4-1.11.41.51.21.00.81.4-0.6-1.30.3
Left kidney weight0.62.95.6-1.4-1.01.82.12.22.32.41.60.4-0.21.7
Right kidney weight0.31.52.7-1.1-0.71.31.41.41.61.61.20.2-0.41.4
Cocaine induced anxiety0.00.10.30.20.30.10.20.10.20.40.50.1-0.2-0.1
Post-drug Anxiety0.20.20.70.80.8-0.3-0.20.0-0.10.0-0.10.60.40.1
Baseline Anxiety0.40.51.40.50.3-0.7-0.9-0.6-0.7-1.1-1.20.20.60.1
Tail length0.83.35.41.61.1-2.1-2.2-2.1-2.2-2.3-2.1-0.10.6-1.9
Length with tail1.46.09.53.12.7-2.9-2.7-2.1-2.4-2.2-3.01.72.3-1.1
Length without tail1.65.29.72.62.7-2.7-2.5-1.6-2.1-1.6-3.12.12.4-0.1
Times rat made contact with spout1.01.12.60.80.5-1.1-1.3-1.2-1.0-1.4-1.1-0.10.4-1.6
Lifetime Intake5.06.112.6-2.0-1.52.93.03.63.12.92.30.5-0.42.6
Liver weight, left0.61.01.9-1.2-1.41.31.21.20.91.10.6-0.6-0.40.1
Liver weight, right1.22.04.3-1.8-2.11.71.51.61.41.60.7-0.6-0.21.3
Locomotor activity0.91.34.1-2.0-1.90.80.40.2-0.7-0.20.0-1.9-1.3-0.5
Locomotor testing distance0.71.34.6-2.2-2.10.80.50.1-0.40.0-0.2-1.8-1.1-0.2
Locomotor testing rearing0.61.24.1-1.9-2.01.00.70.3-0.10.60.1-1.5-1.10.5
Locomotion in novel chamber3.64.68.1-2.8-2.22.52.52.42.02.22.2-1.1-1.90.7
Locomotion in novel chamber post-restriction2.13.44.8-2.1-2.02.12.21.91.41.62.2-1.5-2.00.2
Fecal boli incidents, locomotor time 10.20.31.00.40.50.50.50.50.60.51.00.3-0.3-0.1
Change in fecal boli incidents, locomotor task0.30.30.9-0.4-0.90.50.20.20.90.30.0-0.30.50.7
Time >=10cm from walls, locomotor time 13.13.37.0-0.7-0.52.22.32.42.52.62.30.5-0.40.6
Bouts of movement, locomotor time 13.64.19.71.21.2-2.1-2.2-2.9-2.8-3.1-0.9-1.0-0.8-2.0
Total resting periods, locomotor time 12.62.97.30.91.1-1.8-1.8-2.5-2.3-2.7-0.7-0.8-0.9-1.7
Rest time, locomotor task time 11.01.32.8-1.3-1.41.00.90.30.50.51.4-1.5-1.7-1.0
Distance moved, locomotor task time 10.40.62.30.30.60.10.20.70.20.6-0.41.11.11.5
Vertical activity count, locomotor time 10.51.12.0-1.2-1.11.31.31.40.81.20.8-0.4-0.41.2
Time >=10cm from walls, locomotor time 20.20.31.70.40.4-0.00.2-0.1-0.20.10.8-0.2-0.7-1.3
Bouts of movement, locomotor time 20.50.81.50.71.0-1.2-1.1-1.1-1.1-1.0-1.00.20.10.2
Total resting periods, locomotor time 20.20.30.50.40.6-0.7-0.7-0.7-0.7-0.5-0.60.1-0.10.3
Rest time, locomotor task time 22.22.85.1-2.0-2.02.21.91.61.51.61.9-1.1-1.20.7
Distance moved, locomotor task time 21.21.52.81.21.2-1.5-1.4-1.3-1.7-1.3-1.10.30.5-0.9
Vertical activity count, locomotor time 20.50.71.8-0.2-0.3-0.7-0.7-0.9-1.3-1.0-0.7-0.9-0.4-1.2
Light reinforcement 10.10.41.1-0.2-0.3-0.3-0.2-0.5-0.7-0.7-0.2-0.8-0.8-1.0
Light reinforcement 21.21.93.5-1.1-0.71.51.71.61.31.31.9-0.2-1.41.6
Bone: marrow area2.96.311.8-1.4-1.02.93.03.23.43.32.21.30.62.9
Bone: maximum diameter0.40.82.20.51.00.50.71.01.01.00.71.50.60.7
Bone: maximum force2.23.812.42.42.8-0.5-0.30.80.80.7-0.83.52.82.4
Bone: maximum moment2.13.611.72.32.8-0.6-0.40.70.70.6-0.93.42.72.4
Mean time between licks in bursts0.41.02.90.50.2-1.2-1.4-1.2-1.1-1.2-1.70.00.9-0.0
Mean num. licks in bursts0.20.31.3-0.4-0.6-0.2-0.2-0.3-0.4-0.4-0.3-0.8-0.4-1.1
Cd content in liver1.11.23.3-0.9-0.81.21.30.81.11.31.8-0.6-1.20.2
Co content in liver1.51.84.6-1.0-1.5-0.5-0.7-1.4-1.2-1.1-0.5-2.2-1.3-2.1
Cu content in liver0.10.10.50.0-0.1-0.2-0.2-0.4-0.2-0.10.0-0.5-0.4-0.7
Fe content in liver0.10.20.40.50.30.30.20.40.40.40.20.50.6-0.2
K content in liver0.60.62.10.80.8-0.4-0.40.10.00.1-0.91.31.50.0
Mg content in liver0.10.10.3-0.4-0.40.20.30.40.40.6-0.30.30.50.1
Mn content in liver1.71.85.12.02.3-1.6-1.2-0.8-0.9-0.9-1.01.61.10.1
Na content in liver0.40.40.60.70.8-0.7-0.7-0.5-0.3-0.5-0.70.70.70.1
Rb content in liver1.21.43.9-1.6-2.01.41.20.90.91.10.8-1.2-0.80.2
Se content in liver0.20.30.7-0.30.20.30.60.60.70.70.80.2-0.60.1
Sr content in liver2.52.23.71.81.9-1.9-1.8-1.4-1.5-1.5-1.51.00.8-0.4
Zn content in liver0.91.02.20.91.0-1.5-1.2-1.1-0.7-0.6-1.40.70.7-0.8
Bone: minimum diameter2.34.28.3-1.2-0.72.22.42.72.92.71.71.30.52.5
Time in familiar zone, hab. session 10.10.10.4-0.5-0.20.30.30.60.40.3-0.00.20.10.5
Time in novel zone, hab. session 10.20.20.8-0.4-0.90.40.2-0.20.20.10.3-0.7-0.20.1
Total zone transitions, hab. session 10.20.20.50.70.7-0.5-0.4-0.3-0.3-0.2-0.40.50.5-0.3
Total locomotion distance, hab. session 10.71.02.1-0.9-0.61.11.31.41.31.40.80.40.10.8
Locomotion velocity, hab. session 10.20.20.7-0.3-0.10.40.60.80.70.80.20.50.20.3
Time in familiar zone, hab. session 20.50.51.00.1-0.3-0.5-0.9-0.8-0.9-1.0-0.9-0.60.4-0.9
Time in novel zone, hab. session 20.30.31.30.10.40.10.40.40.70.70.20.80.21.1
Total zone transitions, hab. session 20.71.03.01.11.1-0.3-0.30.40.20.3-0.71.71.71.1
Total locomotion distance, hab. session 20.60.71.5-0.2-0.10.60.71.21.11.10.11.01.01.1
Locomotion velocity, hab. session 20.81.02.3-0.4-0.30.91.01.51.31.30.50.90.71.3
Novel to familiar place preference ratio0.60.72.91.21.7-0.6-0.4-0.1-0.2-0.1-0.11.30.60.6
Novelty place preference0.30.41.70.81.3-0.4-0.1-0.0-0.10.10.11.00.30.6
Time in novel zone, NPP test0.30.31.50.71.2-0.4-0.10.0-0.00.2-0.11.00.30.7
Total zone transitions, NPP test0.81.23.01.71.6-0.7-0.7-0.1-0.4-0.2-0.81.61.70.4
Total locomotion distance, NPP test0.30.41.0-0.1-0.10.60.61.00.70.90.10.70.70.6
Locomotion velocity, NPP test0.10.20.5-0.0-0.10.50.40.70.60.60.20.40.50.3
Intraocular pressure0.81.25.0-1.0-0.6-0.00.2-0.7-0.6-0.31.0-1.6-2.2-1.5
Delta distance traveled before/after self-admin0.80.91.9-0.7-0.9-0.4-0.7-1.1-1.1-1.1-0.5-1.4-0.6-1.2
Delta ambulatory time before/after self-admin0.50.61.6-0.5-0.8-0.4-0.5-1.0-0.8-0.8-0.4-1.2-0.4-1.3
Parametrial fat weight3.07.111.9-2.7-2.33.03.33.33.23.52.8-0.3-1.21.8
Pavlov. Cond. lever latency0.30.41.1-0.6-0.90.50.5-0.00.30.20.8-1.1-0.8-0.7
Pavlov. Cond. magazine entry latency0.40.52.00.71.1-0.3-0.10.40.10.2-0.31.40.90.5
Pavlov. Cond. change in total contacts0.20.20.60.40.8-0.00.20.40.20.30.40.7-0.00.3
Pavlov. Cond. index score0.30.31.00.71.0-0.7-0.6-0.3-0.5-0.5-0.50.70.4-0.0
Pavlov. Cond. latency score0.20.20.70.50.8-0.5-0.4-0.0-0.3-0.3-0.50.80.50.2
Pavlov. Cond. lever contacts0.20.30.90.40.6-0.3-0.30.2-0.00.0-0.61.00.80.7
Pavlov. Cond. magazine entry number0.40.51.2-0.8-1.10.90.70.50.80.70.4-0.4-0.00.7
Pavlov. Cond. intertrial magazine entries0.50.62.6-0.7-0.6-0.20.0-0.4-0.4-0.30.3-1.3-1.6-1.1
Pavlov. Cond. lever-magazine prob. diff.0.40.51.40.91.2-0.7-0.6-0.2-0.5-0.5-0.50.90.60.1
Pavlov. Cond. response bias0.30.31.00.61.0-0.8-0.6-0.3-0.6-0.5-0.50.60.2-0.3
Pavlov. Cond. lever latency0.30.41.8-0.9-1.30.20.2-0.30.10.10.1-1.2-0.6-0.4
Pavlov. Cond. magazine entry latency2.83.48.22.62.9-2.0-1.8-1.0-1.6-1.3-1.72.11.80.0
Pavlov. Cond. change in total contacts0.61.04.41.52.1-0.7-0.4-0.0-0.4-0.1-0.11.60.60.8
Pavlov. Cond. index score1.31.76.11.92.5-1.1-0.9-0.3-0.7-0.5-0.82.01.30.6
Pavlov. Cond. latency score1.11.45.31.72.3-0.9-0.60.0-0.5-0.2-0.62.01.20.7
Pavlov. Cond. lever contacts0.30.41.80.91.3-0.3-0.30.1-0.3-0.3-0.11.10.50.3
Pavlov. Cond. magazine entry number4.04.912.9-3.2-3.62.52.11.31.81.51.9-2.5-2.0-0.2
Pavlov. Cond. intertrial magazine entries0.71.01.7-1.1-1.31.11.00.60.80.61.2-1.2-1.2-0.7
Pavlov. Cond. lever-magazine prob. diff.1.62.27.12.12.7-1.3-1.1-0.5-0.9-0.7-1.02.11.40.7
Pavlov. Cond. response bias1.21.65.11.82.2-1.1-1.0-0.3-0.8-0.7-0.81.81.30.5
Time in closed arm before self-admin0.50.71.6-0.5-0.10.71.01.11.31.01.20.2-0.5-0.2
Time in closed arm after self-admin0.40.41.1-0.8-1.00.80.60.60.60.50.3-0.5-0.30.6
Time in open arm before self-admin0.60.61.5-0.4-1.2-0.1-0.7-0.8-1.0-0.8-1.2-1.00.20.1
Time in open arm after self-admin0.70.71.30.40.5-1.1-1.0-1.1-1.1-1.1-1.0-0.00.3-0.5
Bone: periosteal estimation1.22.54.5-0.10.41.41.62.12.12.01.11.91.02.1
Bone: periosteal perimeter0.71.32.40.30.70.91.01.41.41.40.81.60.91.4
Bone: post-yield work3.95.79.80.51.12.22.33.13.12.91.92.91.73.1
Progressive ratio test 1 active lever presses1.11.33.0-0.7-0.51.41.31.41.71.21.40.2-0.11.4
Progressive ratio test 1 breakpoint1.11.33.1-0.7-0.51.31.31.41.71.11.40.3-0.11.4
Progressive ratio test 1 inactive lever presses0.10.21.0-0.30.4-0.10.20.30.1-0.10.10.4-0.11.0
Progressive ratio test 2 active lever presses3.33.96.8-1.8-1.22.22.42.42.62.02.5-0.1-1.21.5
Progressive ratio test 2 breakpoint3.33.86.7-1.8-1.22.22.42.42.62.02.4-0.1-1.21.5
Progressive ratio test 2 inactive lever presses4.37.011.6-3.4-2.22.83.23.02.52.73.0-1.0-2.61.6
Incentive Sensitization - Responses0.50.71.6-0.10.50.50.81.31.01.10.61.10.21.2
Incentive Sensitization - Breakpoint0.60.81.8-0.30.30.71.01.41.11.20.70.9-0.11.2
Sum of active levers in priming session hrs 5-61.41.32.61.01.5-1.3-0.9-1.4-1.3-1.30.2-0.1-0.8-1.6
Progressive ratio0.81.23.51.11.20.30.50.91.00.90.21.91.61.3
Food seeking constrained by brief footshock0.00.10.30.30.0-0.2-0.2-0.20.0-0.2-0.30.10.50.1
Seeking ratio, punishment vs. effort0.60.92.6-1.3-1.5-0.2-0.4-0.7-0.5-0.7-0.5-1.6-1.0-0.9
Retroperitoneal fat weight5.222.442.3-6.5-5.95.45.44.74.24.94.2-3.0-3.92.1
Reaction time number correct0.30.61.10.70.7-1.0-1.0-0.8-0.8-1.0-1.00.10.2-0.3
Reaction time mean minus median0.61.55.42.32.3-0.8-0.9-0.7-0.7-0.8-0.21.41.10.3
Reaction time mean minus median AUC0.41.02.61.61.6-0.9-1.0-1.0-1.0-1.1-0.40.60.6-0.5
Reaction time num false alarms0.40.61.5-0.6-1.2-0.0-0.5-0.5-0.9-0.8-0.7-1.2-0.3-0.6
Reaction time num false alarms AUC0.50.82.10.0-0.5-0.6-1.0-1.0-1.4-1.2-1.2-0.80.2-0.7
Reaction time trials correct on left0.30.61.10.70.7-1.0-1.0-0.8-0.8-1.0-1.00.10.2-0.3
Reaction time trials on left0.40.71.30.80.8-1.1-1.1-0.8-0.9-1.1-1.00.10.2-0.3
Reaction time mean0.10.10.40.10.40.20.40.20.10.20.60.0-0.40.2
Reaction time mean AUC0.10.10.60.10.30.30.50.30.20.30.80.1-0.40.2
Median of all reaction times0.20.30.6-0.5-0.10.50.70.60.40.60.8-0.1-0.50.3
Reaction time omissions0.60.91.61.31.3-0.9-1.0-0.9-1.3-1.3-0.40.40.5-0.2
Reaction time false alarm rate0.20.31.1-0.6-1.00.2-0.1-0.2-0.6-0.2-0.4-0.8-0.0-0.2
Reaction time premature initiation rate2.83.99.11.91.7-2.5-2.3-1.7-1.5-1.7-3.01.62.3-0.1
Reaction time premature initiations3.56.312.32.42.2-3.2-3.1-2.5-2.2-2.7-3.51.42.2-0.7
Std. dev. reaction times0.20.31.31.11.0-0.2-0.3-0.5-0.6-0.50.40.1-0.0-0.3
Reaction time trials completed0.40.71.30.80.8-1.1-1.1-0.8-0.9-1.1-1.00.10.2-0.3
Reaction time trials AUC0.20.50.90.50.6-0.9-0.9-0.7-0.7-1.0-1.00.10.2-0.2
Run reversals in cocaine runway, females0.70.73.00.40.3-0.0-0.20.50.60.3-1.11.31.71.0
Run reversals in cocaine runway, males0.10.10.4-0.6-0.50.30.30.0-0.00.00.3-0.6-0.3-0.3
Latency to leave start box in cocaine runway0.80.92.7-0.3-0.51.11.11.21.61.30.90.40.20.6
Latency to leave start box in cocaine runway, F0.10.10.3-0.0-0.10.20.30.40.40.60.10.30.0-0.2
Latency to leave start box in cocaine runway, M1.11.03.1-0.1-0.61.41.11.11.81.11.10.30.40.9
Std. dev. time between licks in bursts0.30.41.0-0.3-0.6-0.4-0.7-0.7-0.7-0.8-1.0-0.40.40.0
Total sessions with >9 infusions1.11.32.9-0.2-0.41.41.31.71.31.31.10.50.41.6
Short access day 1 total inactive lever presses1.72.24.3-2.1-1.71.51.71.91.21.81.0-0.6-1.10.9
Short access day 10 total inactive lever presses0.20.51.4-0.8-1.20.40.3-0.1-0.00.10.2-1.1-0.9-1.1
Short access day 1 total infusions2.33.16.0-1.6-1.62.22.12.42.01.91.7-0.3-0.51.5
Short access day 10 total infusions3.34.210.3-0.9-0.72.42.43.22.62.71.71.20.52.2
Short access total infusions2.73.48.1-1.0-1.02.22.12.82.22.31.50.80.52.3
Short access day 1 locomotion1.51.83.5-1.4-1.11.61.61.91.51.31.2-0.0-0.61.7
Short access day 10 total locomotion1.12.03.8-1.0-0.51.41.62.01.91.81.20.8-0.11.8
Short access total locomotion2.32.85.6-1.4-0.91.92.02.42.12.01.50.5-0.41.9
One hour access (0.3 mA shock)4.75.48.6-2.9-2.12.62.82.82.62.42.3-0.6-1.81.8
Compulsive drug intake4.04.78.91.71.0-2.7-2.8-3.0-2.4-2.7-2.8-0.20.9-1.7
One hour access (shock baseline)6.19.414.0-3.3-2.43.73.73.63.63.13.7-0.7-2.12.0
Social response proportion0.30.30.90.90.9-0.4-0.6-0.2-0.5-0.4-0.10.60.6-0.4
Social responses0.60.82.30.70.7-0.8-1.1-1.0-1.5-1.2-0.7-0.10.2-0.8
Social time0.40.51.50.70.5-0.7-0.8-1.0-1.2-0.8-0.6-0.10.3-0.5
Soleus weight2.47.014.7-3.8-3.82.92.72.01.81.92.5-2.7-2.80.7
Bone: stiffness1.01.65.01.92.1-0.3-0.20.50.40.3-0.12.21.70.9
Tibialis anterior weight6.321.241.66.26.5-5.3-4.9-3.6-3.5-3.6-4.84.44.5-0.7
Time to tail flick, vehicle, before self-admin0.91.02.10.60.70.40.61.01.21.20.21.41.11.4
Time to tail flick, vehicle, after self-admin1.11.55.01.21.10.0-0.10.60.50.6-0.82.02.21.7
Time to tail flick, test, before self-admin1.91.96.3-1.5-0.91.21.41.71.31.90.20.60.32.5
Time to tail flick, test, after self-admin0.10.10.40.40.6-0.0-0.0-0.0-0.3-0.10.10.40.1-0.1
Delta time to tail flick, vehicle, before/after SA0.40.41.30.80.6-0.4-0.6-0.4-0.5-0.4-0.80.71.20.3
Delta time to tail flick, test, before/after SA2.42.55.11.61.3-1.5-1.7-2.2-1.7-2.3-0.4-0.7-0.6-2.0
Tibia length0.51.45.91.82.4-1.1-0.7-0.5-0.3-0.4-0.31.70.6-0.2
Ambulatory time before self-admin0.40.52.21.01.5-0.30.00.40.00.40.11.30.40.6
Ambulatory time after self-admin0.10.10.4-0.4-0.0-0.00.30.20.10.30.5-0.1-0.6-0.5
Bone: tissue strength0.00.00.2-0.1-0.10.10.10.0-0.1-0.00.3-0.3-0.40.1
Total heroin consumption4.14.87.62.62.8-2.6-2.4-2.2-2.7-2.2-1.91.31.5-1.3
Bone: trabecular number0.81.24.21.21.6-0.00.20.80.80.7-0.02.11.41.3
Bone: trabecular spacing0.60.82.5-0.8-1.2-0.2-0.4-0.8-0.9-0.7-0.3-1.6-0.9-1.3
Bone: trabecular thickness0.60.81.4-0.8-0.61.01.21.21.01.20.80.0-0.40.9
Bone: trabecular tissue density2.84.18.1-2.5-2.82.01.81.00.60.72.3-2.9-2.8-0.9
Water consumed over 24 hours1.52.03.41.31.1-1.7-1.8-1.8-1.4-1.8-1.50.10.5-1.2
Number of responses in last shaping day0.30.41.2-0.1-0.0-0.6-0.7-0.6-1.1-0.9-0.8-0.3-0.10.2