Hub : Genes

Ctsw

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Brain gene expression Ctsw 0.06 0.04 3.9e-05 0.05 0.04 0.01 0.04 4.1e-05 7.3e-05 7.3e-02 1.8e-04
2 Adipose isoform ratio NM_001024242.1 0.04 0.03 2.1e-03 0.02 0.01 0.01 0.02 1.1e-03 1.5e-02 3.9e-02 4.5e-03
3 Adipose isoform ratio XR_005503314.1 0.04 0.03 2.1e-03 0.02 0.01 0.01 0.02 1.1e-03 1.5e-02 3.7e-02 4.3e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bone: apparent density0.30.50.6-0.60.8-0.8
Area under the delay curve0.10.10.10.1-0.30.3
BMI with tail2.16.88.2-2.92.5-2.5
BMI without tail0.91.92.7-1.71.2-1.2
Body weight4.117.117.8-4.24.1-4.1
Weight adjusted by age3.03.43.5-1.81.9-1.9
Bone surface4.47.77.7-2.82.8-2.8
Bone volume1.42.42.5-1.51.6-1.6
Breakpoint value in progressive ratio session3.53.83.9-1.92.0-2.0
Number of licking bursts0.40.40.5-0.50.7-0.7
Context. condit. distance diff. score2.42.92.91.7-1.71.7
Locomotion velocity, session 10.00.00.0-0.10.0-0.0
Locomotion distance, session 10.50.60.6-0.80.8-0.8
Locomotion velocity, session 23.33.83.9-1.92.0-2.0
Locomotion distance, session 20.81.11.2-1.01.1-1.1
Locomotion velocity, session 30.10.10.20.4-0.30.3
Locomotion distance, session 30.00.00.00.2-0.10.1
Stereotopy head waving bouts, day 30.70.91.00.8-1.01.0
Stereotopy head waving duration, day 31.01.21.40.9-1.21.2
Locomotion velocity, session 70.40.40.60.8-0.50.5
Locomotion distance, session 70.00.00.10.3-0.10.1
Stereotopy head waving bouts, day 70.20.20.20.3-0.50.5
Stereotopy head waving duration, day 70.91.11.3-1.11.0-1.0
Locomotion velocity, session 81.11.31.3-1.11.1-1.1
Locomotion distance, session 80.20.30.30.5-0.50.5
Degree of sensitization distance0.00.00.00.1-0.00.0
Degree of sensitization stereotypy0.40.50.5-0.70.7-0.7
Conditioned locomotion2.12.42.5-1.51.6-1.6
Cocaine response after cond. corrected1.51.71.91.4-1.31.3
Cocaine response after cond. not corrected1.21.31.51.2-1.11.1
Cocaine response before conditioning0.70.91.0-0.91.0-1.0
Saline control response4.35.75.9-2.42.3-2.3
Bone: connectivity density2.23.53.6-1.81.9-1.9
Bone: cortical apparent density0.20.30.4-0.60.6-0.6
Bone: cortical area0.91.41.6-1.01.3-1.3
Bone: cortical porosity0.10.10.1-0.30.2-0.2
Bone: cortical porosity0.50.50.7-0.80.7-0.7
Bone: cortical thickness3.76.16.8-2.22.6-2.6
Bone: cortical thickness1.01.11.4-0.81.2-1.2
Bone: cortical tissue density0.30.40.5-0.70.6-0.6
Condit. Reinf. active minus inactive responses0.30.40.5-0.40.7-0.7
Condit. Reinf. active-inactive response ratio0.10.10.2-0.20.4-0.4
Condit. Reinf. active responses0.20.20.3-0.10.5-0.5
Condit. Reinf. inactive responses0.00.00.10.3-0.10.1
Incentive salience index mean0.50.60.7-0.60.9-0.9
Condit. Reinf. lever presses0.50.60.7-0.60.8-0.8
Condit. Reinf. active minus inactive responses0.10.10.10.4-0.30.3
Condit. Reinf. active-inactive response ratio0.60.60.70.9-0.80.8
Condit. Reinf. active responses0.00.10.1-0.20.3-0.3
Condit. Reinf. inactive responses0.40.40.4-0.70.7-0.7
Condit. Reinf. lever presses2.93.94.2-1.82.0-2.0
Condit. Reinf. lever reinforcers received0.30.40.4-0.60.6-0.6
Conditioned reinforcement - actives0.20.20.30.5-0.50.5
Conditioned reinforcement - inactives6.87.78.22.9-2.72.7
Conditioned locomotion9.711.611.73.4-3.43.4
Patch foraging indifference point 0 sec0.10.10.10.3-0.30.3
Patch foraging indifference point AUC3.43.94.7-2.21.9-1.9
Delay disc. indifference point, 0s delay0.91.01.40.5-1.21.2
Delay disc. indifference point, 16s delay0.60.60.91.0-0.60.6
Delay disc. indifference point, 2s delay0.20.20.30.3-0.50.5
Delay disc. indifference point, 24s delay0.00.00.00.20.0-0.0
Delay disc. indifference point, 4s delay0.20.20.30.3-0.50.5
Delay disc. indifference point, 8s delay0.00.00.1-0.0-0.30.3
Indifference point function ln k9.713.614.13.8-3.63.6
Indifference point function log k9.713.614.13.8-3.63.6
Patch foraging total patch changes 0 sec0.00.10.10.3-0.20.2
Patch foraging total patch changes 12 sec4.76.06.4-2.52.4-2.4
Patch foraging total patch changes 18 sec0.50.60.7-0.90.8-0.8
Patch foraging total patch changes 24 sec2.63.23.4-1.81.7-1.7
Patch foraging total patch changes 6 sec1.01.51.7-1.11.3-1.3
Patch foraging time to switch 0 sec2.43.74.2-1.62.1-2.1
Patch foraging water rate 0 sec4.87.78.22.6-2.92.9
Patch foraging water rate 12 sec9.214.114.63.6-3.83.8
Patch foraging water rate 18 sec3.24.34.62.2-2.02.0
Patch foraging water rate 24 sec4.46.16.52.3-2.62.6
Patch foraging water rate 6 sec3.65.35.82.4-2.32.3
Seeking ratio, delayed vs. immediate footshock0.00.00.00.10.0-0.0
Distance traveled before self-admin0.40.40.7-0.90.5-0.5
Distance traveled after self-admin0.10.10.2-0.40.2-0.2
Extensor digitorum longus weight9.135.636.1-5.96.0-6.0
Bone: elastic displacement0.70.81.31.1-0.80.8
Bone: elastic work0.91.11.2-0.91.1-1.1
Bone: endosteal estimation1.02.22.41.3-1.51.5
Bone: endosteal perimeter1.22.42.61.5-1.61.6
Epididymis fat weight3.37.78.42.5-2.92.9
Delta time in closed arm before/after self-admin0.00.00.0-0.00.1-0.1
Delta time in open arm before/after self-admin0.00.00.1-0.20.1-0.1
Diff in mean of infusions in LGA sessions0.50.50.6-0.60.8-0.8
Delay discount exponential model param0.00.00.0-0.10.2-0.2
Extinction: sum of active levers before priming4.74.74.8-2.22.1-2.1
Active lever presses in extinction session 62.32.32.8-1.71.4-1.4
Bone: final force3.35.35.6-2.42.3-2.3
Bone: final moment2.94.64.9-2.22.1-2.1
Food consumed during 24 hour testing period0.10.10.1-0.20.4-0.4
Glucose2.03.03.11.8-1.71.7
Heart weight3.34.75.92.4-2.02.0
Delay discount hyperbolic model param0.00.00.0-0.00.2-0.2
Intermittent access intake day 1-15 change0.40.40.80.9-0.50.5
Intermittent access intake escalation0.50.50.70.9-0.60.6
Intermittent access intake escalation 20.20.20.20.4-0.50.5
Intermitt. access day 1 inactive lever presses2.12.33.01.7-1.41.4
Intermitt. access day 15 inactive lever presses2.22.43.31.8-1.41.4
Intermitt. access escalation Index4.54.04.31.8-2.12.1
Intermittent access day 1 total infusions5.86.77.02.6-2.62.6
Intermittent access day 15 total infusions8.09.011.13.3-2.82.8
Intermittent access terminal intake (last 3 days)5.45.97.32.7-2.32.3
Intermittent access total infusions4.34.76.22.5-2.02.0
Intermittent access day 1 locomotion3.53.74.62.1-1.81.8
Intermittent access day 15 total locomotion4.95.26.72.6-2.12.1
Intermittent access total locomotion6.57.58.32.9-2.72.7
Intermittent access standard deviation1.11.21.51.2-1.01.0
Left kidney weight0.61.81.91.4-1.31.3
Right kidney weight0.10.30.30.5-0.50.5
Cocaine induced anxiety0.00.00.0-0.00.0-0.0
Post-drug Anxiety1.31.41.5-1.21.2-1.2
Baseline Anxiety2.22.32.7-1.61.5-1.5
Tail length0.72.22.4-1.51.5-1.5
Length with tail2.710.010.5-3.03.2-3.2
Length without tail2.96.46.8-2.32.6-2.6
Times rat made contact with spout0.60.70.8-0.70.9-0.9
Lifetime Intake3.84.35.42.3-1.91.9
Liver weight, left0.10.20.30.2-0.60.6
Liver weight, right0.10.10.20.3-0.40.4
Locomotor activity1.62.63.41.8-1.51.5
Locomotor testing distance2.13.64.42.1-1.81.8
Locomotor testing rearing2.13.23.51.9-1.71.7
Locomotion in novel chamber4.65.75.82.4-2.42.4
Locomotion in novel chamber post-restriction3.54.24.22.1-2.02.0
Fecal boli incidents, locomotor time 10.10.10.1-0.20.4-0.4
Change in fecal boli incidents, locomotor task0.00.00.0-0.0-0.10.1
Time >=10cm from walls, locomotor time 10.50.50.70.8-0.70.7
Bouts of movement, locomotor time 12.52.82.8-1.71.6-1.6
Total resting periods, locomotor time 11.92.02.1-1.41.5-1.5
Rest time, locomotor task time 11.11.21.31.1-1.21.2
Distance moved, locomotor task time 10.00.00.0-0.10.2-0.2
Vertical activity count, locomotor time 11.31.31.71.3-1.11.1
Time >=10cm from walls, locomotor time 20.00.00.1-0.30.0-0.0
Bouts of movement, locomotor time 20.80.81.0-0.71.0-1.0
Total resting periods, locomotor time 20.40.40.5-0.50.7-0.7
Rest time, locomotor task time 22.52.93.11.6-1.71.7
Distance moved, locomotor task time 21.01.21.3-1.11.0-1.0
Vertical activity count, locomotor time 20.00.00.00.20.0-0.0
Light reinforcement 10.20.40.40.5-0.70.7
Light reinforcement 20.71.01.01.0-1.01.0
Bone: marrow area1.12.32.61.4-1.61.6
Bone: maximum diameter0.20.30.3-0.60.5-0.5
Bone: maximum force3.86.56.6-2.52.6-2.6
Bone: maximum moment3.25.55.7-2.32.4-2.4
Mean time between licks in bursts0.30.50.5-0.70.6-0.6
Mean num. licks in bursts0.20.20.20.4-0.40.4
Cd content in liver1.61.71.91.2-1.41.4
Co content in liver1.51.71.81.3-1.31.3
Cu content in liver0.40.50.6-0.60.8-0.8
Fe content in liver0.10.10.1-0.40.4-0.4
K content in liver2.42.42.8-1.31.7-1.7
Mg content in liver0.20.20.3-0.30.5-0.5
Mn content in liver3.53.94.2-1.82.1-2.1
Na content in liver1.31.41.4-1.21.2-1.2
Rb content in liver2.02.52.71.5-1.71.7
Se content in liver0.00.10.10.00.3-0.3
Sr content in liver3.02.83.8-1.91.5-1.5
Zn content in liver1.92.02.3-1.21.5-1.5
Bone: minimum diameter0.81.41.41.2-1.21.2
Time in familiar zone, hab. session 10.20.20.30.6-0.40.4
Time in novel zone, hab. session 10.20.20.30.3-0.50.5
Total zone transitions, hab. session 10.91.31.4-1.01.2-1.2
Total locomotion distance, hab. session 10.30.40.50.6-0.70.7
Locomotion velocity, hab. session 10.00.00.00.1-0.20.2
Time in familiar zone, hab. session 20.00.00.00.2-0.00.0
Time in novel zone, hab. session 20.00.00.1-0.30.1-0.1
Total zone transitions, hab. session 21.31.72.0-1.41.2-1.2
Total locomotion distance, hab. session 20.00.00.00.0-0.20.2
Locomotion velocity, hab. session 20.10.10.10.2-0.40.4
Novel to familiar place preference ratio1.01.11.4-1.21.0-1.0
Novelty place preference0.40.40.6-0.80.5-0.5
Time in novel zone, NPP test0.20.20.4-0.60.4-0.4
Total zone transitions, NPP test2.43.53.9-2.01.8-1.8
Total locomotion distance, NPP test0.00.00.1-0.30.1-0.1
Locomotion velocity, NPP test0.10.10.1-0.30.3-0.3
Intraocular pressure0.70.91.01.0-1.01.0
Delta distance traveled before/after self-admin0.10.10.10.2-0.30.3
Delta ambulatory time before/after self-admin0.00.00.00.1-0.20.2
Parametrial fat weight2.75.35.52.2-2.42.4
Pavlov. Cond. lever latency0.20.20.40.6-0.40.4
Pavlov. Cond. magazine entry latency0.10.10.3-0.50.2-0.2
Pavlov. Cond. change in total contacts0.00.00.1-0.20.2-0.2
Pavlov. Cond. index score0.10.10.2-0.50.3-0.3
Pavlov. Cond. latency score0.00.00.1-0.30.1-0.1
Pavlov. Cond. lever contacts0.00.00.0-0.10.0-0.0
Pavlov. Cond. magazine entry number0.20.30.40.7-0.50.5
Pavlov. Cond. intertrial magazine entries0.40.50.91.0-0.50.5
Pavlov. Cond. lever-magazine prob. diff.0.30.40.6-0.80.5-0.5
Pavlov. Cond. response bias0.10.10.1-0.40.3-0.3
Pavlov. Cond. lever latency0.60.90.90.9-0.90.9
Pavlov. Cond. magazine entry latency4.55.25.5-2.12.3-2.3
Pavlov. Cond. change in total contacts2.33.23.3-1.71.8-1.8
Pavlov. Cond. index score3.14.04.1-1.92.0-2.0
Pavlov. Cond. latency score2.63.23.4-1.71.9-1.9
Pavlov. Cond. lever contacts0.60.80.9-0.90.9-0.9
Pavlov. Cond. magazine entry number7.99.69.83.0-3.13.1
Pavlov. Cond. intertrial magazine entries1.41.81.91.3-1.41.4
Pavlov. Cond. lever-magazine prob. diff.3.74.74.9-2.12.2-2.2
Pavlov. Cond. response bias2.23.03.1-1.71.8-1.8
Time in closed arm before self-admin0.10.10.1-0.20.3-0.3
Time in closed arm after self-admin0.00.00.10.30.2-0.2
Time in open arm before self-admin0.40.50.60.8-0.60.6
Time in open arm after self-admin0.10.20.20.3-0.40.4
Bone: periosteal estimation0.00.00.00.1-0.10.1
Bone: periosteal perimeter0.10.10.1-0.30.4-0.4
Bone: post-yield work0.30.30.4-0.60.6-0.6
Progressive ratio test 1 active lever presses3.13.23.71.9-1.71.7
Progressive ratio test 1 breakpoint2.72.83.41.8-1.61.6
Progressive ratio test 1 inactive lever presses1.41.61.71.3-1.21.2
Progressive ratio test 2 active lever presses4.24.55.82.4-2.02.0
Progressive ratio test 2 breakpoint5.46.17.62.8-2.32.3
Progressive ratio test 2 inactive lever presses9.611.112.13.5-3.33.3
Incentive Sensitization - Responses0.40.40.70.8-0.50.5
Incentive Sensitization - Breakpoint0.60.61.01.0-0.60.6
Sum of active levers in priming session hrs 5-61.51.51.5-1.21.2-1.2
Progressive ratio2.12.53.2-1.81.5-1.5
Food seeking constrained by brief footshock0.30.30.4-0.40.7-0.7
Seeking ratio, punishment vs. effort1.72.12.81.7-1.31.3
Retroperitoneal fat weight6.521.421.64.6-4.64.6
Reaction time number correct0.30.50.8-0.90.6-0.6
Reaction time mean minus median4.45.86.6-2.12.6-2.6
Reaction time mean minus median AUC2.73.54.1-1.52.0-2.0
Reaction time num false alarms0.30.40.60.8-0.50.5
Reaction time num false alarms AUC0.00.00.00.10.2-0.2
Reaction time trials correct on left0.30.50.8-0.90.6-0.6
Reaction time trials on left0.50.71.0-1.00.7-0.7
Reaction time mean0.10.10.2-0.30.4-0.4
Reaction time mean AUC0.10.10.2-0.20.4-0.4
Median of all reaction times0.00.00.00.2-0.10.1
Reaction time omissions2.43.33.9-1.52.0-2.0
Reaction time false alarm rate0.20.30.70.8-0.30.3
Reaction time premature initiation rate2.33.03.4-1.81.7-1.7
Reaction time premature initiations3.95.66.4-2.52.3-2.3
Std. dev. reaction times1.42.02.3-1.21.5-1.5
Reaction time trials completed0.50.71.0-1.00.7-0.7
Reaction time trials AUC0.20.30.6-0.80.4-0.4
Run reversals in cocaine runway, females0.40.40.4-0.60.6-0.6
Run reversals in cocaine runway, males0.20.20.30.5-0.30.3
Latency to leave start box in cocaine runway0.00.00.10.30.1-0.1
Latency to leave start box in cocaine runway, F0.00.00.0-0.00.2-0.2
Latency to leave start box in cocaine runway, M0.00.00.10.30.1-0.1
Std. dev. time between licks in bursts0.10.20.20.3-0.40.4
Total sessions with >9 infusions1.51.72.31.5-1.21.2
Short access day 1 total inactive lever presses5.25.86.32.2-2.52.5
Short access day 10 total inactive lever presses3.64.04.72.2-1.91.9
Short access day 1 total infusions3.03.23.61.9-1.71.7
Short access day 10 total infusions1.31.51.91.4-1.11.1
Short access total infusions1.41.61.81.3-1.21.2
Short access day 1 locomotion1.92.13.41.8-1.21.2
Short access day 10 total locomotion1.51.72.11.4-1.21.2
Short access total locomotion1.21.31.61.3-1.01.0
One hour access (0.3 mA shock)9.811.414.33.8-3.23.2
Compulsive drug intake2.72.82.8-1.71.7-1.7
One hour access (shock baseline)8.810.212.43.5-3.03.0
Social response proportion1.21.31.4-1.01.2-1.2
Social responses0.40.50.6-0.50.8-0.8
Social time0.50.60.7-0.90.8-0.8
Soleus weight4.713.813.93.7-3.73.7
Bone: stiffness2.84.44.7-2.22.1-2.1
Tibialis anterior weight12.843.743.9-6.66.6-6.6
Time to tail flick, vehicle, before self-admin0.50.50.6-0.80.7-0.7
Time to tail flick, vehicle, after self-admin1.41.51.6-1.31.2-1.2
Time to tail flick, test, before self-admin0.40.40.70.8-0.50.5
Time to tail flick, test, after self-admin0.10.10.1-0.20.3-0.3
Delta time to tail flick, vehicle, before/after SA0.60.60.6-0.70.8-0.8
Delta time to tail flick, test, before/after SA1.51.31.5-1.21.1-1.1
Tibia length1.23.33.3-1.81.8-1.8
Ambulatory time before self-admin0.30.30.4-0.70.5-0.5
Ambulatory time after self-admin0.10.20.20.3-0.40.4
Bone: tissue strength0.00.00.0-0.10.2-0.2
Total heroin consumption5.86.87.6-2.82.5-2.5
Bone: trabecular number0.50.80.9-0.71.0-1.0
Bone: trabecular spacing0.20.30.30.5-0.60.6
Bone: trabecular thickness0.40.50.70.9-0.60.6
Bone: trabecular tissue density4.25.96.02.4-2.42.4
Water consumed over 24 hours1.01.21.3-1.11.1-1.1
Number of responses in last shaping day1.21.21.61.3-1.01.0