Hub : Traits

Bone: maximum diameter

Tags: Physiology · Bone

Project: r01_doug_adams

2 loci · 2 genes with independent associations · 2 total associated genes

Significant Loci

#	Chr	Start pos	End pos	# assoc genes	# joint models	Best TWAS P	Best GWAS P	Cond GWAS P	Joint genes
1	chr1	254086596	255485810	1	1	7.4e-08	1.94e-06	1.24e-04	Tcf7l2
2	chr20	53722628	54429288	1	1	5.7e-11	1.60e-01	1.00e+00	LOC103694460

Pleiotropic Associations

Trait	Chi2 ratio	# genes+	# genes++	% genes++	Corr	Corr P	Genes
BMI with tail	13.91	2	1	50	0	1e+00	LOC103694460 Tcf7l2
BMI without tail	4.56	2	0	0	0	1e+00	LOC103694460 Tcf7l2
Body weight	9.1	2	1	50	0	1e+00	LOC103694460 Tcf7l2
Epididymis fat weight	9.86	1	0	0	0	1e+00	Tcf7l2
Left kidney weight	15.24	1	1	50	0	1e+00	LOC103694460
Right kidney weight	12.61	1	1	50	0	1e+00	LOC103694460
Liver weight, left	10.61	1	0	0	0	1e+00	LOC103694460
Liver weight, right	13.64	2	1	50	0	1e+00	LOC103694460 Tcf7l2
Parametrial fat weight	6.54	2	0	0	0	1e+00	LOC103694460 Tcf7l2
Retroperitoneal fat weight	18.04	2	1	50	0	1e+00	LOC103694460 Tcf7l2
Intraocular pressure	14.94	2	1	50	0	1e+00	LOC103694460 Tcf7l2
Extensor digitorum longus weight	5.18	1	0	0	0	1e+00	LOC103694460
Soleus weight	2.3	1	0	0	0	1e+00	LOC103694460
Tibialis anterior weight	11.7	1	1	50	0	1e+00	LOC103694460
Tibia length	4.63	1	0	0	0	1e+00	LOC103694460
Number of licking bursts	4.57	1	0	0	0	1e+00	Tcf7l2
Patch foraging indifference point 0 sec	12.96	1	0	0	0	1e+00	LOC103694460
Patch foraging indifference point AUC	12.1	1	0	0	0	1e+00	LOC103694460
Patch foraging total patch changes 0 sec	12.64	1	0	0	0	1e+00	LOC103694460
Patch foraging total patch changes 12 sec	10.05	1	0	0	0	1e+00	LOC103694460
Patch foraging total patch changes 18 sec	11.62	1	0	0	0	1e+00	LOC103694460
Patch foraging total patch changes 24 sec	9.3	1	0	0	0	1e+00	LOC103694460
Patch foraging total patch changes 6 sec	4.31	1	0	0	0	1e+00	Tcf7l2
Patch foraging time to switch 0 sec	6.28	1	0	0	0	1e+00	LOC103694460
Locomotor testing rearing	4.07	1	0	0	0	1e+00	LOC103694460
Light reinforcement 1	8.24	1	0	0	0	1e+00	LOC103694460
Light reinforcement 2	4.35	1	0	0	0	1e+00	LOC103694460
Reaction time num false alarms	4.16	1	0	0	0	1e+00	LOC103694460
Saline control response	5.77	1	0	0	0	1e+00	LOC103694460
Condit. Reinf. active minus inactive responses	12.75	1	0	0	0	1e+00	Tcf7l2
Condit. Reinf. active-inactive response ratio	9.63	1	0	0	0	1e+00	Tcf7l2
Condit. Reinf. active responses	12.11	1	0	0	0	1e+00	Tcf7l2
Condit. Reinf. lever presses	6.33	1	0	0	0	1e+00	Tcf7l2
Condit. Reinf. lever reinforcers received	10.57	1	0	0	0	1e+00	Tcf7l2
Pavlov. Cond. lever latency	7.06	2	0	0	0	1e+00	LOC103694460 Tcf7l2
Pavlov. Cond. change in total contacts	4.33	2	0	0	0	1e+00	LOC103694460 Tcf7l2
Pavlov. Cond. index score	9.99	2	0	0	0	1e+00	LOC103694460 Tcf7l2
Pavlov. Cond. latency score	10.76	1	0	0	0	1e+00	LOC103694460
Pavlov. Cond. lever contacts	8.82	1	0	0	0	1e+00	LOC103694460
Pavlov. Cond. magazine entry number	20.26	1	0	0	0	1e+00	LOC103694460
Pavlov. Cond. lever-magazine prob. diff.	7.4	2	0	0	0	1e+00	LOC103694460 Tcf7l2
Pavlov. Cond. response bias	8.44	2	0	0	0	1e+00	LOC103694460 Tcf7l2
Cocaine induced anxiety	5.82	1	0	0	0	1e+00	Tcf7l2
Baseline Anxiety	8.74	1	0	0	0	1e+00	Tcf7l2
One hour access (0.3 mA shock)	6.59	1	0	0	0	1e+00	Tcf7l2
Locomotion velocity, session 2	13.34	1	0	0	0	1e+00	LOC103694460
Locomotion distance, session 2	10.62	1	0	0	0	1e+00	LOC103694460
Locomotion velocity, session 3	7.97	1	0	0	0	1e+00	LOC103694460
Locomotion distance, session 3	4.68	1	0	0	0	1e+00	LOC103694460
Locomotion distance, session 7	9.27	1	0	0	0	1e+00	LOC103694460
Stereotopy head waving bouts, day 7	7.71	1	0	0	0	1e+00	LOC103694460
Stereotopy head waving duration, day 7	11.78	1	0	0	0	1e+00	LOC103694460
Locomotion distance, session 8	8.35	1	0	0	0	1e+00	LOC103694460
Degree of sensitization stereotypy	6.17	1	0	0	0	1e+00	LOC103694460
Time in familiar zone, hab. session 2	5.14	1	0	0	0	1e+00	Tcf7l2
Pavlov. Cond. intertrial magazine entries	7.44	1	0	0	0	1e+00	LOC103694460
Bone: apparent density	3.4	1	0	0	0	1e+00	Tcf7l2
Bone surface	3.12	1	0	0	0	1e+00	Tcf7l2
Bone volume	4.82	1	0	0	0	1e+00	Tcf7l2
Bone: cortical apparent density	4.36	1	0	0	0	1e+00	Tcf7l2
Bone: cortical area	12.78	2	1	50	0	1e+00	LOC103694460 Tcf7l2
Bone: cortical porosity	16.96	1	0	0	0	1e+00	LOC103694460
Bone: cortical porosity	8.89	1	0	0	0	1e+00	LOC103694460
Bone: cortical thickness	5.61	1	0	0	0	1e+00	Tcf7l2
Bone: cortical tissue density	4.88	1	0	0	0	1e+00	Tcf7l2
Bone: elastic work	11.21	1	0	0	0	1e+00	LOC103694460
Bone: endosteal estimation	3.95	2	0	0	0	1e+00	LOC103694460 Tcf7l2
Bone: endosteal perimeter	17.58	2	1	50	0	1e+00	LOC103694460 Tcf7l2
Bone: final force	5.84	1	0	0	0	1e+00	Tcf7l2
Bone: final moment	6.25	1	0	0	0	1e+00	Tcf7l2
Bone: marrow area	3.37	2	0	0	0	1e+00	LOC103694460 Tcf7l2
Bone: maximum force	5.34	1	0	0	0	1e+00	Tcf7l2
Bone: maximum moment	5.58	1	0	0	0	1e+00	Tcf7l2
Bone: minimum diameter	8.55	2	0	0	0	1e+00	LOC103694460 Tcf7l2
Bone: periosteal estimation	10.85	1	0	0	0	1e+00	Tcf7l2
Bone: periosteal perimeter	14.88	2	1	50	0	1e+00	LOC103694460 Tcf7l2
Bone: stiffness	4.3	1	0	0	0	1e+00	Tcf7l2
Bone: trabecular spacing	8.2	1	0	0	0	1e+00	LOC103694460
Bone: trabecular thickness	7.22	1	0	0	0	1e+00	Tcf7l2
Bone: trabecular tissue density	10.67	1	0	0	0	1e+00	LOC103694460
Area under the delay curve	5.85	1	0	0	0	1e+00	LOC103694460
Delay disc. indifference point, 2s delay	4.93	1	0	0	0	1e+00	LOC103694460
Delay disc. indifference point, 4s delay	7.29	1	0	0	0	1e+00	LOC103694460
Delay disc. indifference point, 8s delay	5.11	1	0	0	0	1e+00	LOC103694460
Delay discount exponential model param	6.82	1	0	0	0	1e+00	LOC103694460
Delay discount hyperbolic model param	7.48	1	0	0	0	1e+00	LOC103694460
Bouts of movement, locomotor time 1	4.98	1	0	0	0	1e+00	Tcf7l2
Total resting periods, locomotor time 1	4.86	1	0	0	0	1e+00	Tcf7l2
Co content in liver	6.98	2	0	0	0	1e+00	LOC103694460 Tcf7l2
Cu content in liver	43.87	1	1	50	0	1e+00	LOC103694460
Fe content in liver	26.96	1	1	50	0	1e+00	LOC103694460
K content in liver	46.75	1	1	50	0	1e+00	LOC103694460
Mg content in liver	13.38	1	0	0	0	1e+00	LOC103694460
Na content in liver	13.35	1	0	0	0	1e+00	LOC103694460
Rb content in liver	81.33	1	1	50	0	1e+00	LOC103694460
Se content in liver	9.04	1	0	0	0	1e+00	LOC103694460
Sr content in liver	22.24	1	0	0	0	1e+00	LOC103694460
Zn content in liver	5.29	2	0	0	0	1e+00	LOC103694460 Tcf7l2

Associations by panel

Tissue	RNA modality	# hits	% hits/tests	Avg chisq
Adipose	alternative polyA	0	0	1.86
Adipose	alternative TSS	0	0	1.84
Adipose	gene expression	1	0	1.82
Adipose	isoform ratio	0	0	1.88
Adipose	intron excision ratio	0	0	1.97
Adipose	mRNA stability	0	0	1.81
BLA	alternative polyA	0	0	1.9
BLA	alternative TSS	0	0	1.96
BLA	gene expression	0	0	1.86
BLA	isoform ratio	0	0	1.79
BLA	intron excision ratio	0	0	1.81
BLA	mRNA stability	0	0	1.87
Brain	alternative polyA	0	0	1.82
Brain	alternative TSS	0	0	1.88
Brain	gene expression	0	0	1.82
Brain	isoform ratio	0	0	1.89
Brain	intron excision ratio	0	0	1.82
Brain	mRNA stability	0	0	1.8
Eye	alternative polyA	0	0	1.71
Eye	alternative TSS	0	0	1.69
Eye	gene expression	0	0	1.84
Eye	isoform ratio	0	0	1.86
Eye	intron excision ratio	0	0	1.68
Eye	mRNA stability	0	0	1.84
IL	alternative polyA	0	0	1.71
IL	alternative TSS	0	0	1.81
IL	gene expression	0	0	1.87
IL	isoform ratio	0	0	1.77
IL	intron excision ratio	0	0	1.86
IL	mRNA stability	0	0	1.86
LHb	alternative polyA	0	0	1.87
LHb	alternative TSS	0	0	1.75
LHb	gene expression	0	0	1.85
LHb	isoform ratio	0	0	1.86
LHb	intron excision ratio	0	0	1.82
LHb	mRNA stability	0	0	1.92
Liver	alternative polyA	0	0	1.88
Liver	alternative TSS	0	0	1.7
Liver	gene expression	0	0	1.83
Liver	isoform ratio	0	0	1.87
Liver	intron excision ratio	1	0	1.92
Liver	mRNA stability	0	0	1.81
NAcc	alternative polyA	0	0	1.79
NAcc	alternative TSS	0	0	1.91
NAcc	gene expression	0	0	1.83
NAcc	isoform ratio	0	0	1.83
NAcc	intron excision ratio	0	0	1.78
NAcc	mRNA stability	0	0	1.89
OFC	alternative polyA	0	0	1.66
OFC	alternative TSS	0	0	1.72
OFC	gene expression	0	0	1.91
OFC	isoform ratio	0	0	1.78
OFC	intron excision ratio	0	0	1.77
OFC	mRNA stability	0	0	1.9
PL	alternative polyA	0	0	1.85
PL	alternative TSS	0	0	1.87
PL	gene expression	0	0	1.86
PL	isoform ratio	0	0	1.82
PL	intron excision ratio	0	0	1.77
PL	mRNA stability	0	0	1.85
pVTA	alternative polyA	0	0	1.94
pVTA	alternative TSS	0	0	1.82
pVTA	gene expression	0	0	1.88
pVTA	isoform ratio	0	0	1.8
pVTA	intron excision ratio	0	0	1.88
pVTA	mRNA stability	0	0	1.89
RMTg	alternative polyA	0	0	1.83
RMTg	alternative TSS	0	0	1.96
RMTg	gene expression	0	0	1.83
RMTg	isoform ratio	0	0	1.92
RMTg	intron excision ratio	0	0	1.85
RMTg	mRNA stability	0	0	1.83