Hub : Genes

Brca2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 LHb mRNA stability Brca2 0.29 0.15 1.4e-03 0.11 0.12 0.12 0.12 1.3e-03 7.5e-04 1.1e-03 1.2e-03
2 Liver mRNA stability Brca2 0.18 0.08 5.6e-16 0.1 0.13 0.13 0.13 2.5e-11 2.3e-14 5.2e-14 3.2e-14
3 PL mRNA stability Brca2 0.33 0.12 0.0e+00 0.22 0.24 0.24 0.24 1.8e-23 1.3e-26 2.4e-26 1.8e-26
4 Adipose mRNA stability Brca2 0.36 0.13 0.0e+00 0.15 0.22 0.21 0.21 1.2e-16 5.2e-24 3.7e-23 5.4e-23
5 Brain gene expression Brca2 0.43 0.14 0.0e+00 0.31 0.33 0.34 0.34 1.0e-29 1.6e-31 4.1e-32 1.8e-32
6 Brain mRNA stability Brca2 0.5 0.15 0.0e+00 0.36 0.37 0.36 0.37 1.8e-34 9.2e-36 3.1e-35 6.8e-36
7 NAcc isoform ratio XM_017598372.2 0.06 0.04 5.1e-05 0.04 0.04 0.03 0.04 8.0e-06 3.0e-05 1.1e-04 4.9e-05
8 NAcc mRNA stability Brca2 0.23 0.1 0.0e+00 0.15 0.16 0.16 0.16 3.1e-17 1.5e-17 2.9e-18 3.4e-18
9 Adipose alternative polyA XM_039089544.1 0.03 0.02 3.1e-03 0.02 0.02 0.02 0.02 2.4e-03 6.6e-03 2.7e-03 5.1e-03
10 Liver gene expression Brca2 0.04 0.03 4.1e-04 0.03 0.01 0.02 0.02 4.3e-04 8.3e-03 3.5e-03 1.9e-03
11 NAcc isoform ratio XM_039089542.1 0.06 0.04 6.9e-05 0.04 0.03 0.04 0.03 5.3e-06 2.0e-04 5.3e-05 1.1e-04
12 OFC gene expression Brca2 0.29 0.15 3.3e-03 0.16 0.07 0.16 0.14 1.4e-04 8.0e-03 1.6e-04 3.1e-04
13 pVTA mRNA stability Brca2 0.2 0.1 2.2e-05 0.13 0.12 0.1 0.12 3.6e-06 4.8e-06 3.9e-05 6.1e-06
14 RMTg gene expression Brca2 0.26 0.14 1.5e-03 0.11 0.1 0.11 0.11 6.5e-04 1.1e-03 7.9e-04 5.8e-04
15 PL isoform ratio XM_039089542.1 0.04 0.03 5.6e-03 0.02 0.02 0.02 0.03 3.3e-03 9.2e-04 1.1e-03 8.1e-04
16 PL gene expression Brca2 0.39 0.13 0.0e+00 0.25 0.28 0.28 0.28 1.1e-27 8.5e-31 1.4e-30 2.6e-31
17 NAcc gene expression Brca2 0.3 0.13 0.0e+00 0.22 0.22 0.23 0.22 2.7e-25 4.5e-25 6.5e-26 3.0e-25
18 BLA gene expression Brca2 0.37 0.13 3.7e-14 0.25 0.25 0.27 0.26 1.5e-13 9.4e-14 7.3e-15 6.6e-14
19 BLA mRNA stability Brca2 0.41 0.15 6.0e-15 0.25 0.28 0.29 0.28 1.9e-13 4.9e-15 7.6e-16 4.0e-15
20 Adipose gene expression Brca2 0.26 0.11 2.2e-16 0.03 0.1 0.09 0.08 8.5e-04 1.5e-11 4.7e-10 2.3e-09
21 pVTA gene expression Brca2 0.25 0.12 1.3e-06 0.12 0.12 0.11 0.12 8.8e-06 7.4e-06 2.0e-05 8.5e-06

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21
Bone: apparent density4.88.012.33.33.03.43.53.12.9-3.0-2.8-2.9-2.92.7-2.7-2.82.8-2.72.9-2.8-1.9-2.03.01.4
Area under the delay curve1.41.55.4-1.1-0.8-1.8-1.8-1.5-1.10.61.00.60.6-0.90.91.1-1.11.1-1.41.40.80.7-2.3-1.2
BMI with tail0.92.88.12.32.31.31.41.21.6-2.8-1.6-2.8-2.81.5-1.5-1.41.4-1.40.9-0.8-0.1-1.0-0.2-1.0
BMI without tail2.24.67.32.52.71.91.71.92.3-2.5-2.4-2.4-2.42.2-2.2-2.32.4-2.21.8-2.1-2.0-2.40.50.8
Body weight12.351.780.78.78.87.17.36.97.4-9.0-7.6-9.0-9.07.2-7.2-7.27.3-7.26.3-6.2-5.7-6.23.71.8
Weight adjusted by age1.11.22.31.11.01.41.41.31.1-0.8-1.0-0.8-0.81.1-1.1-0.81.1-1.01.2-1.1-1.3-1.11.50.8
Bone surface4.88.513.23.63.43.33.43.03.0-3.5-3.0-3.5-3.52.9-2.8-2.92.9-2.82.7-2.6-1.8-1.62.30.8
Bone volume2.94.98.12.82.52.62.82.32.2-2.7-2.2-2.7-2.72.1-2.1-2.12.1-2.02.1-1.9-1.2-1.32.10.4
Breakpoint value in progressive ratio session0.10.11.2-0.10.2-0.5-0.6-0.20.1-0.1-0.1-0.1-0.10.1-0.1-0.10.1-0.1-0.20.10.20.0-1.1-0.2
Number of licking bursts1.72.03.31.31.21.61.61.61.5-1.0-1.4-0.9-0.91.3-1.3-1.41.4-1.31.5-1.5-1.8-1.81.71.1
Context. condit. distance diff. score2.83.44.71.92.21.51.31.72.0-1.9-2.1-1.8-1.82.1-2.1-2.12.1-2.11.7-1.9-2.0-1.80.51.3
Locomotion velocity, session 10.70.81.4-1.0-0.9-1.1-1.2-1.0-0.81.10.81.11.1-0.80.80.7-0.70.8-0.90.70.1-0.5-1.1-0.3
Locomotion distance, session 11.62.14.3-1.8-1.7-1.5-1.6-1.4-1.42.11.42.02.0-1.51.51.2-1.21.4-1.41.10.1-0.1-1.1-0.2
Locomotion velocity, session 20.20.20.5-0.6-0.4-0.6-0.7-0.3-0.20.70.40.60.6-0.30.30.3-0.30.3-0.30.3-0.3-0.3-0.60.2
Locomotion distance, session 21.01.54.4-1.6-1.5-1.1-1.3-0.8-0.92.11.02.02.0-0.90.90.8-0.80.8-0.70.4-0.8-1.4-0.41.0
Locomotion velocity, session 30.10.10.50.20.30.1-0.00.00.1-0.0-0.3-0.0-0.00.1-0.1-0.40.4-0.30.1-0.3-0.3-0.7-0.20.1
Locomotion distance, session 30.10.10.4-0.2-0.20.20.20.20.00.4-0.00.40.40.1-0.1-0.10.1-0.10.3-0.30.00.40.60.6
Stereotopy head waving bouts, day 33.94.68.82.32.22.32.32.22.2-2.1-2.1-2.0-2.02.1-2.1-2.12.1-2.02.1-2.0-2.6-3.01.81.1
Stereotopy head waving duration, day 30.20.21.10.50.40.40.50.40.4-0.5-0.2-0.4-0.40.3-0.3-0.20.2-0.20.2-0.1-0.7-1.00.3-0.3
Locomotion velocity, session 71.11.34.0-1.0-0.8-1.5-1.6-1.3-0.90.81.00.80.8-1.01.01.0-1.01.0-1.41.20.80.5-2.0-1.0
Locomotion distance, session 70.30.41.2-0.8-0.5-0.8-1.1-0.6-0.40.90.30.90.9-0.40.40.2-0.20.2-0.50.20.2-0.0-1.10.4
Stereotopy head waving bouts, day 70.60.74.3-1.0-0.8-0.8-0.8-0.5-0.60.90.70.80.8-0.40.40.8-0.80.6-0.40.60.82.1-0.40.2
Stereotopy head waving duration, day 70.70.95.8-1.0-0.9-0.9-0.9-0.7-0.70.80.90.70.7-0.60.60.9-0.90.8-0.60.91.02.4-0.5-0.3
Locomotion velocity, session 80.10.10.50.10.2-0.2-0.3-0.20.0-0.2-0.1-0.2-0.2-0.00.0-0.20.2-0.1-0.2-0.0-0.6-0.6-0.7-0.2
Locomotion distance, session 80.71.14.60.91.10.70.50.81.0-0.8-1.0-0.8-0.80.9-0.9-1.11.1-1.10.7-1.0-1.7-2.1-0.00.7
Degree of sensitization distance1.01.02.1-1.2-0.9-1.3-1.5-1.1-0.91.10.91.11.1-0.90.90.8-0.80.9-1.00.90.70.6-1.4-0.3
Degree of sensitization stereotypy0.80.98.3-0.8-0.7-0.8-0.9-0.7-0.70.60.70.60.6-0.50.50.8-0.80.7-0.50.81.42.9-0.7-0.3
Conditioned locomotion0.10.10.40.30.10.40.50.30.2-0.2-0.1-0.2-0.20.1-0.1-0.10.1-0.10.2-0.10.00.60.60.0
Cocaine response after cond. corrected0.60.74.50.50.2-0.10.4-0.4-0.3-1.10.4-1.2-1.2-0.40.40.6-0.60.5-0.60.91.20.9-0.3-2.1
Cocaine response after cond. not corrected0.50.63.70.30.2-0.30.0-0.5-0.4-0.90.4-1.0-1.0-0.40.40.6-0.60.5-0.70.90.90.9-0.8-1.9
Cocaine response before conditioning0.20.20.9-0.30.0-0.3-0.6-0.00.20.5-0.30.60.60.3-0.3-0.40.4-0.30.1-0.4-0.8-0.0-0.61.0
Saline control response4.45.88.52.02.12.52.12.62.5-1.4-2.5-1.4-1.42.7-2.7-2.62.6-2.72.8-2.8-2.9-1.72.32.9
Bone: connectivity density7.011.014.33.83.63.83.73.53.5-3.3-3.5-3.3-3.33.2-3.2-3.53.5-3.33.3-3.4-2.7-2.72.91.9
Bone: cortical apparent density1.01.45.4-1.0-0.8-1.3-1.3-1.2-1.10.80.90.70.7-1.01.00.9-1.01.0-1.21.11.82.3-1.4-0.9
Bone: cortical area1.21.93.61.71.91.11.11.21.5-1.9-1.5-1.8-1.81.4-1.4-1.51.5-1.41.0-1.2-0.7-0.70.00.2
Bone: cortical porosity0.20.20.80.40.30.40.50.50.4-0.4-0.4-0.5-0.50.5-0.5-0.30.3-0.40.5-0.30.00.90.50.3
Bone: cortical porosity0.10.11.5-0.3-0.2-0.1-0.2-0.0-0.10.30.10.30.30.1-0.10.2-0.10.00.10.00.41.20.00.4
Bone: cortical thickness1.01.73.31.71.81.11.11.11.4-1.8-1.5-1.7-1.71.3-1.3-1.51.5-1.41.0-1.2-0.6-0.50.10.1
Bone: cortical thickness1.31.52.21.21.41.21.01.31.4-1.0-1.4-0.9-0.91.4-1.4-1.51.5-1.41.3-1.5-1.3-0.90.71.2
Bone: cortical tissue density1.11.45.6-1.0-0.9-1.3-1.2-1.3-1.10.81.00.80.8-1.01.01.0-1.01.1-1.21.11.82.4-1.3-1.0
Condit. Reinf. active minus inactive responses1.01.11.8-1.0-0.9-1.2-1.1-1.2-1.10.41.10.30.3-0.90.91.2-1.20.9-1.11.21.21.3-1.2-1.0
Condit. Reinf. active-inactive response ratio0.70.82.5-0.6-0.5-1.0-0.9-0.9-0.8-0.10.8-0.0-0.0-0.60.60.9-0.90.7-0.91.11.21.6-1.2-1.1
Condit. Reinf. active responses0.40.51.0-1.0-0.8-0.9-1.0-0.8-0.70.60.80.50.5-0.50.50.7-0.70.5-0.60.70.40.4-0.8-0.1
Condit. Reinf. inactive responses0.60.72.0-1.2-1.0-0.8-1.1-0.6-0.61.40.71.31.3-0.50.50.5-0.50.5-0.40.2-0.5-1.0-0.40.9
Incentive salience index mean0.60.81.2-1.1-1.0-1.1-1.1-1.0-0.90.81.00.70.7-0.80.80.9-0.90.7-0.80.90.80.9-0.9-0.3
Condit. Reinf. lever presses0.30.41.2-0.9-0.7-0.7-0.8-0.5-0.51.10.51.01.0-0.40.40.4-0.40.5-0.40.30.10.2-0.40.4
Condit. Reinf. active minus inactive responses0.81.01.80.91.30.60.30.91.3-0.8-1.3-0.8-0.81.3-1.3-1.31.3-1.21.0-1.2-0.6-0.1-0.21.1
Condit. Reinf. active-inactive response ratio0.20.30.50.30.60.0-0.20.30.6-0.3-0.7-0.2-0.20.7-0.7-0.70.7-0.60.4-0.6-0.3-0.3-0.60.7
Condit. Reinf. active responses0.91.32.31.01.40.70.41.11.5-0.9-1.4-0.9-0.91.5-1.5-1.41.4-1.41.1-1.3-0.9-0.1-0.21.2
Condit. Reinf. inactive responses0.50.61.10.70.80.70.50.91.0-0.6-0.8-0.6-0.60.9-0.9-0.80.8-0.90.9-0.8-1.0-0.30.40.9
Condit. Reinf. lever presses0.10.10.30.20.40.20.00.40.5-0.1-0.4-0.1-0.10.5-0.5-0.40.4-0.40.4-0.4-0.6-0.4-0.10.5
Condit. Reinf. lever reinforcers received0.50.81.50.61.00.40.00.81.2-0.5-1.0-0.5-0.51.2-1.2-1.11.1-1.10.9-1.0-0.60.2-0.41.2
Conditioned reinforcement - actives6.66.610.02.42.62.52.22.72.7-2.1-2.7-2.1-2.12.8-2.8-2.72.7-2.82.7-2.7-3.2-2.91.82.3
Conditioned reinforcement - inactives0.91.01.80.80.71.21.11.11.0-0.5-0.9-0.5-0.50.9-0.9-1.00.9-0.91.1-1.1-1.2-1.11.31.1
Conditioned locomotion3.84.65.82.12.32.11.92.32.3-1.9-2.3-1.9-1.92.4-2.4-2.32.4-2.42.3-2.4-2.1-1.51.51.9
Patch foraging indifference point 0 sec0.40.63.70.60.21.21.31.00.6-0.2-0.4-0.2-0.20.6-0.6-0.40.5-0.51.0-0.7-0.8-0.41.90.9
Patch foraging indifference point AUC1.21.42.11.01.01.21.11.31.3-0.7-1.2-0.7-0.71.2-1.2-1.31.2-1.21.3-1.4-1.4-1.21.21.3
Delay disc. indifference point, 0s delay1.11.27.50.30.4-1.0-0.8-1.0-0.5-0.80.4-0.8-0.8-0.70.70.6-0.60.5-1.31.21.20.7-2.3-2.7
Delay disc. indifference point, 16s delay0.50.51.4-0.9-0.6-1.1-1.2-0.8-0.70.50.60.40.4-0.40.40.7-0.70.6-0.60.70.20.3-1.2-0.2
Delay disc. indifference point, 2s delay3.63.910.3-1.7-1.4-2.6-2.5-2.3-1.91.01.81.01.0-1.81.81.9-1.91.9-2.32.32.01.4-3.2-2.4
Delay disc. indifference point, 24s delay0.70.71.4-0.9-0.8-1.1-1.2-1.0-0.90.50.80.60.6-0.70.70.9-0.90.8-0.90.90.60.8-1.2-0.6
Delay disc. indifference point, 4s delay1.61.74.9-1.0-0.8-1.7-1.6-1.5-1.20.61.20.60.6-1.21.21.2-1.21.2-1.61.51.10.7-2.2-1.8
Delay disc. indifference point, 8s delay0.50.51.5-0.9-0.6-1.1-1.2-0.8-0.60.60.60.70.7-0.40.40.6-0.60.6-0.60.6-0.20.1-1.20.0
Indifference point function ln k0.10.21.4-0.1-0.10.30.20.40.20.4-0.20.50.50.3-0.3-0.30.3-0.30.5-0.6-0.6-0.10.71.2
Indifference point function log k0.10.21.4-0.1-0.10.30.20.40.20.4-0.20.50.50.3-0.3-0.30.3-0.30.5-0.6-0.6-0.10.71.2
Patch foraging total patch changes 0 sec0.50.74.70.50.11.31.31.00.6-0.0-0.40.00.00.6-0.6-0.40.5-0.51.1-0.8-0.9-0.52.21.1
Patch foraging total patch changes 12 sec0.50.61.80.70.51.01.10.90.7-0.6-0.6-0.6-0.60.7-0.7-0.60.6-0.60.9-0.7-0.8-0.51.40.5
Patch foraging total patch changes 18 sec0.60.84.00.70.41.31.41.10.8-0.2-0.6-0.2-0.20.6-0.6-0.60.6-0.71.1-0.9-1.0-0.92.00.9
Patch foraging total patch changes 24 sec0.91.04.40.20.11.10.91.20.90.5-0.70.50.50.8-0.9-0.80.8-0.81.3-1.2-1.2-0.61.92.1
Patch foraging total patch changes 6 sec0.91.44.81.00.71.61.61.41.1-0.6-0.9-0.7-0.71.0-1.1-0.90.9-1.01.4-1.2-1.3-1.02.21.3
Patch foraging time to switch 0 sec3.65.519.3-1.2-1.3-2.4-1.8-2.6-2.30.22.20.20.2-2.52.52.4-2.42.4-2.93.12.81.5-2.9-4.4
Patch foraging water rate 0 sec4.97.916.42.12.13.22.93.32.9-1.2-2.7-1.2-1.22.9-2.9-2.82.9-2.93.4-3.4-3.0-1.63.74.1
Patch foraging water rate 12 sec0.81.25.30.30.41.10.71.21.00.3-0.90.30.31.1-1.1-1.11.0-1.11.4-1.4-1.4-0.61.52.3
Patch foraging water rate 18 sec0.20.32.4-0.6-0.3-0.2-0.60.10.10.8-0.00.80.80.3-0.3-0.20.1-0.20.4-0.4-0.5-0.0-0.01.5
Patch foraging water rate 24 sec2.83.96.81.61.82.11.82.22.1-1.1-2.1-1.2-1.22.2-2.2-2.22.1-2.22.3-2.4-2.0-1.11.92.6
Patch foraging water rate 6 sec0.81.23.20.60.71.10.91.21.1-0.1-1.0-0.1-0.11.0-1.1-1.21.1-1.21.3-1.4-1.6-1.21.31.8
Seeking ratio, delayed vs. immediate footshock1.82.13.1-1.4-1.7-1.0-0.9-1.3-1.51.71.51.81.8-1.71.71.5-1.51.6-1.31.31.70.9-0.1-1.0
Distance traveled before self-admin0.40.41.5-0.8-0.6-1.0-1.1-0.7-0.50.60.60.60.6-0.50.50.5-0.50.4-0.70.60.1-0.2-1.2-0.4
Distance traveled after self-admin0.10.10.4-0.3-0.1-0.1-0.30.10.20.3-0.10.30.30.2-0.2-0.10.1-0.20.2-0.2-0.6-0.2-0.20.7
Extensor digitorum longus weight5.220.326.95.05.24.44.24.64.9-4.8-4.8-4.9-4.94.9-4.9-4.84.8-4.84.4-4.4-3.9-3.82.62.6
Bone: elastic displacement0.60.60.90.90.81.00.90.80.7-0.8-0.9-0.7-0.70.7-0.7-0.90.9-0.80.8-0.9-0.7-0.60.80.6
Bone: elastic work4.45.77.32.72.72.72.62.62.5-2.6-2.6-2.5-2.52.5-2.5-2.52.5-2.52.5-2.5-1.6-0.42.11.5
Bone: endosteal estimation1.63.55.91.81.62.12.12.11.9-1.4-1.7-1.4-1.41.8-1.8-1.81.7-1.82.0-1.9-2.4-2.42.21.6
Bone: endosteal perimeter1.32.75.11.51.51.61.51.81.8-1.2-1.6-1.2-1.21.8-1.8-1.61.6-1.71.8-1.7-2.3-2.21.41.6
Epididymis fat weight0.10.20.60.40.50.10.10.10.2-0.7-0.3-0.7-0.70.4-0.4-0.20.2-0.30.2-0.00.10.8-0.3-0.2
Delta time in closed arm before/after self-admin0.10.10.20.10.30.0-0.10.20.3-0.2-0.3-0.2-0.20.2-0.3-0.40.4-0.30.2-0.40.20.2-0.30.4
Delta time in open arm before/after self-admin3.43.34.7-2.1-2.2-1.9-1.8-1.9-2.02.02.02.02.0-2.02.02.0-2.01.9-1.81.91.00.6-1.1-1.1
Diff in mean of infusions in LGA sessions0.20.21.0-0.1-0.00.1-0.10.20.20.4-0.20.40.40.3-0.3-0.30.2-0.30.3-0.4-0.8-1.00.10.8
Delay discount exponential model param1.51.65.51.30.91.92.01.51.2-0.8-1.1-0.8-0.81.0-1.0-1.21.2-1.11.4-1.4-0.7-0.72.30.9
Extinction: sum of active levers before priming1.31.32.2-1.4-1.3-1.4-1.5-1.2-1.11.41.11.41.4-1.11.11.1-1.11.1-1.11.00.80.5-1.2-0.4
Active lever presses in extinction session 60.10.10.10.20.20.30.20.20.3-0.1-0.3-0.1-0.10.2-0.2-0.30.3-0.30.2-0.3-0.1-0.30.20.3
Bone: final force2.43.96.12.42.51.91.92.12.3-2.3-2.2-2.2-2.22.2-2.2-2.12.1-2.21.9-1.9-1.4-0.71.00.9
Bone: final moment2.03.35.12.22.31.81.81.92.1-2.1-2.0-2.0-2.02.0-2.0-1.91.9-2.01.8-1.7-1.2-0.71.00.8
Food consumed during 24 hour testing period0.80.95.40.80.61.01.10.90.7-0.6-0.6-0.6-0.60.7-0.7-0.70.7-0.70.9-0.8-1.5-2.31.30.6
Glucose0.91.32.8-0.9-0.8-1.2-1.2-1.3-1.10.61.00.60.6-1.11.11.1-1.11.1-1.31.31.71.4-1.4-1.3
Heart weight0.71.05.80.10.40.60.21.01.00.4-0.90.30.31.1-1.1-1.11.1-1.11.2-1.5-1.1-0.50.72.4
Delay discount hyperbolic model param1.81.95.81.41.01.92.01.61.3-0.8-1.2-0.8-0.81.1-1.1-1.31.3-1.21.5-1.5-1.0-0.92.41.2
Intermittent access intake day 1-15 change2.62.65.61.41.31.81.71.81.6-0.9-1.5-1.0-1.01.4-1.5-1.61.5-1.51.7-1.7-2.2-2.41.91.6
Intermittent access intake escalation2.62.66.01.31.21.71.51.71.6-0.7-1.5-0.8-0.81.5-1.5-1.61.6-1.51.7-1.8-2.3-2.51.71.8
Intermittent access intake escalation 20.40.41.60.10.10.60.50.60.50.3-0.40.30.30.4-0.4-0.50.5-0.50.6-0.7-1.2-1.31.01.1
Intermitt. access day 1 inactive lever presses1.01.02.70.90.81.41.31.21.0-0.5-1.0-0.4-0.41.0-1.0-1.01.0-1.01.3-1.2-0.7-0.31.61.2
Intermitt. access day 15 inactive lever presses0.40.42.80.3-0.1-0.00.4-0.4-0.6-0.60.5-0.6-0.6-0.60.60.6-0.70.6-0.60.90.80.30.1-1.7
Intermitt. access escalation Index0.50.51.7-0.7-0.6-0.4-0.7-0.3-0.31.20.31.21.2-0.30.30.2-0.10.2-0.2-0.1-0.9-1.3-0.20.7
Intermittent access day 1 total infusions0.60.71.7-1.2-1.0-1.2-1.3-0.8-0.71.00.90.90.9-0.70.70.8-0.80.7-0.80.7-0.1-0.8-1.1-0.0
Intermittent access day 15 total infusions0.60.74.80.10.20.50.20.70.60.2-0.40.10.10.6-0.6-0.50.5-0.60.7-0.8-1.7-2.20.71.3
Intermittent access terminal intake (last 3 days)0.20.32.7-0.5-0.5-0.3-0.3-0.1-0.10.60.30.50.5-0.10.10.3-0.30.1-0.00.1-1.0-1.60.10.5
Intermittent access total infusions0.50.51.8-0.9-0.7-0.9-1.0-0.7-0.60.70.70.60.6-0.50.50.7-0.70.5-0.60.6-0.5-1.3-0.8-0.2
Intermittent access day 1 locomotion1.92.03.6-1.7-1.5-1.8-1.9-1.6-1.41.41.41.31.3-1.31.31.4-1.41.3-1.51.41.00.7-1.7-0.7
Intermittent access day 15 total locomotion0.40.53.00.00.30.1-0.20.40.60.2-0.40.10.10.5-0.5-0.60.6-0.60.5-0.7-1.4-1.7-0.11.2
Intermittent access total locomotion0.70.82.2-1.2-0.9-1.3-1.5-0.9-0.81.10.81.01.0-0.70.70.7-0.70.7-0.80.7-0.1-0.7-1.30.0
Intermittent access standard deviation0.50.51.70.90.61.01.30.70.5-0.8-0.4-0.9-0.90.4-0.4-0.40.4-0.40.6-0.4-0.3-0.71.3-0.1
Left kidney weight11.432.242.36.46.55.95.85.96.1-6.0-6.2-6.1-6.16.2-6.2-6.06.0-6.05.8-5.7-4.2-2.54.03.3
Right kidney weight8.523.831.55.65.65.15.05.05.2-5.3-5.3-5.3-5.35.1-5.1-5.15.2-5.04.7-4.8-4.3-3.43.32.5
Cocaine induced anxiety0.50.61.0-0.9-0.7-0.9-1.0-0.9-0.80.90.70.90.9-0.70.70.7-0.70.7-0.70.70.50.4-0.9-0.3
Post-drug Anxiety5.25.78.2-2.5-2.3-2.9-2.8-2.8-2.62.12.42.12.1-2.42.42.5-2.52.4-2.72.61.80.9-2.8-2.0
Baseline Anxiety5.05.37.7-2.1-2.0-2.6-2.4-2.7-2.51.42.51.41.4-2.52.52.5-2.52.5-2.72.82.00.7-2.6-2.6
Tail length7.723.330.85.35.54.54.34.65.1-5.0-5.2-5.0-5.05.0-5.0-5.25.2-5.04.4-4.8-5.5-5.42.42.6
Length with tail16.259.281.08.89.07.67.57.58.0-8.7-8.2-8.8-8.87.9-7.9-8.08.0-7.97.2-7.2-7.2-6.94.43.4
Length without tail8.719.133.95.45.44.44.64.24.5-5.7-4.6-5.8-5.84.5-4.5-4.34.3-4.33.9-3.6-2.7-2.32.40.8
Times rat made contact with spout1.21.47.11.01.10.90.81.11.2-1.0-1.1-0.9-0.91.0-1.1-1.21.1-1.11.0-1.1-1.6-2.70.40.8
Lifetime Intake0.60.71.9-0.9-0.8-1.0-1.0-0.9-0.80.60.90.50.5-0.80.80.9-0.90.8-0.91.0-0.2-1.4-1.0-0.7
Liver weight, left1.52.45.61.71.42.12.31.81.5-1.3-1.5-1.3-1.31.5-1.4-1.41.4-1.31.8-1.5-0.41.22.40.9
Liver weight, right4.57.59.43.13.03.03.03.03.0-2.8-2.9-2.8-2.82.9-2.9-2.92.9-2.82.8-2.8-1.8-1.32.31.7
Locomotor activity2.94.78.61.72.11.81.32.42.5-1.3-2.4-1.4-1.42.7-2.7-2.52.5-2.62.5-2.6-2.3-1.01.12.9
Locomotor testing distance1.42.44.21.31.41.61.41.81.7-0.9-1.6-0.9-0.91.8-1.8-1.61.7-1.71.9-1.8-1.4-0.51.62.1
Locomotor testing rearing0.10.10.9-0.1-0.20.40.40.40.10.2-0.00.20.20.2-0.2-0.00.1-0.10.4-0.3-0.00.50.90.8
Locomotion in novel chamber0.81.01.50.80.91.00.91.01.0-0.6-1.0-0.6-0.61.0-1.0-1.21.0-1.11.1-1.2-1.0-1.00.91.2
Locomotion in novel chamber post-restriction3.44.16.31.82.02.01.62.22.2-1.4-2.2-1.4-1.42.4-2.3-2.32.3-2.32.3-2.4-2.1-1.31.52.5
Fecal boli incidents, locomotor time 11.41.52.11.11.31.21.01.31.4-1.0-1.3-1.0-1.01.4-1.4-1.41.4-1.31.4-1.4-1.3-0.80.81.4
Change in fecal boli incidents, locomotor task0.60.61.7-0.5-0.6-0.6-0.4-0.8-0.80.30.80.40.4-0.90.90.9-0.90.8-0.91.01.00.8-0.4-1.3
Time >=10cm from walls, locomotor time 13.13.24.8-1.7-1.6-2.1-2.0-2.0-1.81.41.81.41.4-1.91.91.8-1.81.8-2.12.01.30.3-2.2-2.0
Bouts of movement, locomotor time 12.12.33.41.51.51.51.41.51.5-1.5-1.5-1.6-1.61.7-1.7-1.51.5-1.61.6-1.5-1.8-1.31.11.3
Total resting periods, locomotor time 11.71.92.81.31.41.31.21.41.4-1.5-1.4-1.5-1.51.6-1.6-1.41.4-1.51.5-1.3-1.7-1.00.91.2
Rest time, locomotor task time 10.50.61.10.90.90.70.80.70.8-1.1-0.8-1.0-1.00.8-0.8-0.70.7-0.80.7-0.6-0.5-0.40.40.2
Distance moved, locomotor task time 10.30.40.9-0.8-0.7-0.7-0.8-0.5-0.51.00.50.90.9-0.50.50.4-0.40.5-0.50.30.1-0.0-0.50.3
Vertical activity count, locomotor time 10.50.63.30.00.20.30.00.50.50.3-0.50.20.20.6-0.6-0.60.6-0.50.6-0.8-1.8-1.60.41.5
Time >=10cm from walls, locomotor time 20.30.32.10.60.6-0.2-0.1-0.30.1-0.9-0.2-0.8-0.8-0.10.1-0.00.0-0.0-0.40.30.50.1-1.1-1.4
Bouts of movement, locomotor time 22.32.43.31.51.61.51.41.61.6-1.7-1.5-1.8-1.81.8-1.8-1.51.5-1.61.7-1.5-1.8-1.11.21.3
Total resting periods, locomotor time 22.22.33.41.51.51.51.51.51.5-1.7-1.4-1.8-1.81.7-1.7-1.41.4-1.51.6-1.4-1.8-1.11.21.1
Rest time, locomotor task time 20.20.20.3-0.5-0.5-0.5-0.5-0.5-0.50.40.50.30.3-0.50.50.6-0.60.5-0.50.60.10.1-0.4-0.4
Distance moved, locomotor task time 20.20.20.40.40.40.60.50.50.5-0.2-0.50.00.00.4-0.4-0.50.5-0.50.5-0.6-0.3-0.30.60.7
Vertical activity count, locomotor time 23.23.54.61.81.82.11.92.12.0-1.5-1.9-1.3-1.32.0-2.0-2.02.0-1.92.1-2.1-1.8-1.31.92.0
Light reinforcement 11.01.83.6-1.6-1.3-1.7-1.9-1.4-1.11.51.21.51.5-1.21.21.1-1.21.1-1.31.21.10.9-1.8-0.5
Light reinforcement 20.10.10.2-0.4-0.4-0.2-0.2-0.2-0.30.40.30.40.4-0.30.30.3-0.30.3-0.20.20.30.30.1-0.0
Bone: marrow area1.73.66.21.81.62.22.12.22.0-1.3-1.7-1.3-1.31.8-1.8-1.81.8-1.82.1-1.9-2.5-2.52.31.7
Bone: maximum diameter1.63.04.12.02.01.81.81.81.8-2.0-1.7-2.0-2.01.7-1.7-1.71.7-1.71.6-1.5-1.5-1.61.20.6
Bone: maximum force2.54.25.62.32.42.12.12.22.3-2.2-2.2-2.1-2.12.2-2.2-2.22.2-2.22.1-2.1-1.7-1.31.41.3
Bone: maximum moment2.13.64.62.12.22.02.02.02.1-2.0-2.0-1.9-1.92.0-2.0-2.02.0-2.02.0-1.9-1.5-1.31.41.2
Mean time between licks in bursts1.72.48.1-1.7-1.7-1.3-1.3-1.3-1.51.71.51.71.7-1.41.41.5-1.51.5-1.21.32.12.9-0.6-0.4
Mean num. licks in bursts0.10.20.6-0.4-0.2-0.6-0.6-0.5-0.50.10.40.10.1-0.30.30.4-0.40.3-0.40.50.50.1-0.8-0.4
Cd content in liver1.41.65.1-1.6-1.6-0.7-1.0-0.6-0.82.21.02.32.3-0.90.90.7-0.70.8-0.40.2-0.7-1.70.41.3
Co content in liver1.31.55.90.90.71.51.41.31.0-0.4-0.9-0.3-0.30.8-0.9-1.01.0-1.01.2-1.3-1.9-2.41.91.3
Cu content in liver0.10.10.5-0.1-0.20.30.20.20.10.6-0.00.60.6-0.00.0-0.10.10.00.2-0.30.0-0.00.70.7
Fe content in liver2.02.33.31.41.61.41.11.61.8-1.1-1.8-1.2-1.21.8-1.8-1.81.8-1.81.7-1.8-1.3-1.00.91.7
K content in liver0.50.57.90.20.20.10.10.00.1-0.2-0.2-0.3-0.30.1-0.1-0.10.1-0.10.0-0.01.32.8-0.1-0.2
Mg content in liver0.50.51.90.80.80.70.70.70.7-0.7-0.8-0.7-0.70.6-0.6-0.70.7-0.60.6-0.70.41.40.40.2
Mn content in liver0.80.98.2-0.6-0.8-0.5-0.4-0.7-0.80.50.70.70.7-0.80.80.8-0.80.8-0.70.81.72.9-0.1-0.6
Na content in liver0.30.34.70.30.4-0.0-0.00.00.2-0.4-0.4-0.3-0.30.2-0.2-0.20.2-0.2-0.0-0.11.02.2-0.5-0.3
Rb content in liver2.12.63.5-1.8-1.8-1.6-1.6-1.6-1.71.91.71.91.9-1.71.71.7-1.71.8-1.61.51.31.3-1.0-0.8
Se content in liver0.20.31.40.40.6-0.3-0.3-0.10.3-0.9-0.3-0.8-0.80.1-0.1-0.30.3-0.3-0.30.10.0-0.8-1.2-0.8
Sr content in liver0.60.62.30.80.51.11.30.90.6-0.6-0.6-0.6-0.60.5-0.5-0.50.5-0.50.8-0.6-0.30.71.50.4
Zn content in liver4.34.77.12.42.22.62.72.42.2-2.1-2.1-2.1-2.12.1-2.1-2.12.1-2.02.2-2.1-2.2-2.02.41.2
Bone: minimum diameter0.00.10.80.10.00.20.20.20.20.0-0.10.00.00.1-0.1-0.10.1-0.10.2-0.20.20.90.30.2
Time in familiar zone, hab. session 10.50.53.8-0.1-0.4-0.00.2-0.3-0.50.10.50.10.1-0.60.60.6-0.60.7-0.40.61.41.90.4-0.9
Time in novel zone, hab. session 10.30.30.60.50.70.30.20.40.6-0.6-0.6-0.6-0.60.7-0.7-0.60.6-0.70.5-0.5-0.8-0.8-0.20.4
Total zone transitions, hab. session 11.41.93.7-1.9-1.6-1.7-1.9-1.4-1.21.91.41.81.8-1.21.21.3-1.31.2-1.21.10.30.2-1.40.1
Total locomotion distance, hab. session 10.60.91.8-1.2-1.0-1.3-1.3-1.0-0.90.91.00.90.9-0.80.81.0-1.00.9-1.01.00.50.5-1.2-0.5
Locomotion velocity, hab. session 11.52.13.8-1.8-1.6-1.8-1.9-1.5-1.41.61.51.51.5-1.31.31.5-1.51.3-1.41.40.60.4-1.7-0.5
Time in familiar zone, hab. session 20.20.21.40.1-0.1-0.20.0-0.4-0.3-0.30.4-0.3-0.3-0.50.50.4-0.40.4-0.60.60.5-0.2-0.4-1.2
Time in novel zone, hab. session 20.30.30.9-0.7-0.5-0.5-0.7-0.3-0.30.70.30.80.8-0.10.10.3-0.30.2-0.10.10.21.0-0.30.7
Total zone transitions, hab. session 20.10.20.90.10.30.20.00.30.40.2-0.40.10.10.4-0.4-0.50.5-0.40.3-0.5-1.0-0.70.10.7
Total locomotion distance, hab. session 20.10.10.4-0.5-0.4-0.4-0.5-0.2-0.20.60.30.60.6-0.10.10.3-0.30.2-0.20.2-0.30.2-0.30.4
Locomotion velocity, hab. session 20.10.10.4-0.5-0.4-0.4-0.5-0.2-0.10.60.30.60.6-0.10.10.2-0.20.1-0.10.1-0.40.1-0.20.4
Novel to familiar place preference ratio0.10.11.0-0.2-0.0-0.1-0.20.10.10.10.00.20.20.2-0.20.0-0.0-0.10.10.00.21.0-0.10.3
Novelty place preference0.20.21.6-0.5-0.4-0.4-0.5-0.2-0.20.50.30.50.5-0.10.10.3-0.30.2-0.10.30.41.3-0.30.2
Time in novel zone, NPP test0.10.11.8-0.3-0.2-0.2-0.3-0.00.00.20.10.30.30.1-0.10.2-0.20.00.00.10.41.4-0.20.2
Total zone transitions, NPP test0.10.11.0-0.20.0-0.2-0.30.00.10.3-0.10.40.40.1-0.1-0.20.2-0.20.0-0.2-0.9-1.0-0.30.5
Total locomotion distance, NPP test0.20.31.3-0.6-0.3-0.8-1.0-0.6-0.30.40.40.50.5-0.20.20.3-0.30.2-0.40.4-0.4-0.6-1.10.0
Locomotion velocity, NPP test0.20.31.2-0.5-0.2-0.6-0.8-0.2-0.00.50.10.50.50.1-0.10.0-0.0-0.1-0.1-0.0-1.0-1.1-0.80.6
Intraocular pressure1.92.73.81.61.71.71.61.81.7-1.4-1.8-1.4-1.42.0-2.0-1.71.8-1.71.9-1.8-0.90.81.41.5
Delta distance traveled before/after self-admin0.30.31.30.20.20.70.60.60.50.1-0.50.10.10.5-0.5-0.50.5-0.50.7-0.8-0.7-0.21.01.1
Delta ambulatory time before/after self-admin0.10.10.4-0.4-0.40.0-0.0-0.0-0.20.60.20.60.6-0.10.10.1-0.20.10.1-0.1-0.10.30.50.6
Parametrial fat weight0.30.66.00.70.50.50.70.20.1-0.8-0.2-0.8-0.80.1-0.1-0.00.10.10.10.11.12.40.4-0.8
Pavlov. Cond. lever latency3.13.95.32.32.22.22.32.12.1-2.1-2.1-2.1-2.12.0-2.0-2.02.0-2.02.0-2.0-1.6-1.01.81.0
Pavlov. Cond. magazine entry latency0.10.10.20.30.40.20.00.30.5-0.2-0.4-0.2-0.20.3-0.3-0.50.5-0.40.2-0.4-0.3-0.1-0.20.4
Pavlov. Cond. change in total contacts1.11.23.2-0.9-0.8-1.4-1.4-1.3-1.00.51.00.50.5-1.01.01.1-1.11.0-1.31.31.10.2-1.8-1.3
Pavlov. Cond. index score0.30.30.9-0.6-0.5-0.8-0.8-0.7-0.50.50.50.50.5-0.50.50.5-0.50.5-0.70.60.70.5-0.9-0.4
Pavlov. Cond. latency score0.60.81.7-1.0-0.8-1.2-1.2-1.0-0.80.80.80.80.8-0.90.90.8-0.80.8-1.00.90.80.4-1.3-0.6
Pavlov. Cond. lever contacts2.42.83.7-1.9-1.8-1.9-1.9-1.8-1.71.61.81.71.7-1.71.71.7-1.71.7-1.71.71.51.0-1.6-1.0
Pavlov. Cond. magazine entry number0.30.30.6-0.4-0.6-0.4-0.1-0.6-0.70.30.70.30.3-0.70.70.8-0.80.7-0.60.70.40.20.0-0.8
Pavlov. Cond. intertrial magazine entries0.60.81.5-1.2-1.2-0.8-0.8-0.8-0.91.11.11.01.0-0.90.90.9-0.90.9-0.70.70.2-0.7-0.20.0
Pavlov. Cond. lever-magazine prob. diff.0.20.30.7-0.5-0.4-0.7-0.7-0.6-0.40.30.50.30.3-0.50.50.5-0.50.4-0.60.60.60.4-0.8-0.5
Pavlov. Cond. response bias0.00.00.2-0.10.1-0.2-0.3-0.00.10.0-0.10.00.00.1-0.1-0.10.1-0.1-0.0-0.00.30.5-0.50.1
Pavlov. Cond. lever latency0.30.41.70.80.41.01.20.60.3-0.8-0.4-0.9-0.90.3-0.3-0.30.3-0.30.6-0.30.30.51.3-0.3
Pavlov. Cond. magazine entry latency2.93.411.5-1.7-1.4-2.1-2.2-1.8-1.51.41.51.31.3-1.51.51.6-1.61.6-1.81.72.53.4-2.4-1.2
Pavlov. Cond. change in total contacts0.20.30.9-0.7-0.4-0.7-1.0-0.3-0.10.90.20.90.9-0.10.10.1-0.10.2-0.20.00.20.9-0.80.7
Pavlov. Cond. index score1.11.43.3-1.4-1.1-1.6-1.8-1.2-0.91.41.01.41.4-0.80.80.9-0.90.9-1.10.91.01.5-1.70.0
Pavlov. Cond. latency score1.21.53.2-1.4-1.1-1.6-1.8-1.2-1.01.31.01.31.3-0.90.91.0-1.01.0-1.11.01.21.7-1.7-0.2
Pavlov. Cond. lever contacts0.40.51.9-0.9-0.6-1.1-1.3-0.8-0.50.80.60.90.9-0.50.50.5-0.50.5-0.70.60.20.1-1.4-0.1
Pavlov. Cond. magazine entry number2.53.112.21.81.51.92.11.61.4-1.7-1.4-1.7-1.71.3-1.3-1.41.4-1.41.5-1.4-2.4-3.51.90.5
Pavlov. Cond. intertrial magazine entries1.21.68.80.90.91.11.01.11.0-0.7-1.0-0.7-0.71.0-1.0-1.11.1-1.11.1-1.2-2.3-3.01.01.1
Pavlov. Cond. lever-magazine prob. diff.1.31.63.6-1.5-1.1-1.6-1.9-1.2-0.91.51.01.51.5-0.90.90.9-0.91.0-1.10.91.21.8-1.80.0
Pavlov. Cond. response bias1.01.43.6-1.5-1.0-1.6-1.9-1.1-0.81.41.01.41.4-0.80.80.9-0.90.9-1.10.90.61.0-1.80.0
Time in closed arm before self-admin2.83.25.11.71.62.01.92.01.8-1.2-1.8-1.2-1.21.9-1.9-1.81.7-1.82.1-1.9-2.2-1.42.01.8
Time in closed arm after self-admin2.22.35.01.11.31.51.21.71.7-0.6-1.6-0.6-0.61.7-1.7-1.71.7-1.71.8-2.0-1.6-0.91.42.2
Time in open arm before self-admin0.10.10.20.20.3-0.0-0.10.10.2-0.3-0.2-0.3-0.30.2-0.2-0.30.3-0.30.0-0.2-0.1-0.4-0.40.0
Time in open arm after self-admin0.50.50.9-0.6-0.7-0.8-0.6-0.8-0.80.30.80.30.3-0.80.80.8-0.80.8-0.80.90.40.0-0.6-1.0
Bone: periosteal estimation2.04.25.22.22.22.12.02.22.2-2.0-2.1-2.0-2.02.1-2.1-2.12.1-2.12.0-2.0-2.3-2.31.51.2
Bone: periosteal perimeter0.71.11.61.01.20.80.61.01.2-0.9-1.2-0.8-0.81.2-1.2-1.31.3-1.21.0-1.2-1.2-1.00.21.0
Bone: post-yield work0.40.52.60.60.60.70.70.70.6-0.5-0.6-0.5-0.50.6-0.6-0.60.6-0.60.7-0.7-0.7-1.60.70.5
Progressive ratio test 1 active lever presses0.70.81.00.90.90.80.80.91.0-0.8-0.9-0.9-0.91.0-1.0-0.80.8-1.00.9-0.8-0.9-0.80.60.7
Progressive ratio test 1 breakpoint0.70.71.00.90.90.80.70.90.9-0.9-0.9-1.0-1.01.0-1.0-0.80.8-0.90.9-0.8-0.9-0.80.50.6
Progressive ratio test 1 inactive lever presses2.22.55.61.21.31.61.41.71.6-0.9-1.5-1.0-1.01.7-1.7-1.51.6-1.61.8-1.8-2.4-1.71.61.9
Progressive ratio test 2 active lever presses1.71.83.41.01.21.10.81.41.5-0.7-1.4-0.8-0.81.6-1.6-1.51.5-1.61.5-1.6-1.7-1.50.81.9
Progressive ratio test 2 breakpoint1.01.13.00.50.80.70.41.11.2-0.3-1.0-0.4-0.41.2-1.2-1.11.2-1.21.2-1.3-1.5-1.50.41.7
Progressive ratio test 2 inactive lever presses5.36.110.82.02.02.62.42.72.5-1.4-2.4-1.5-1.52.5-2.5-2.52.5-2.52.8-2.8-3.3-2.72.72.9
Incentive Sensitization - Responses0.20.21.6-0.4-0.2-0.0-0.30.20.20.8-0.20.70.70.2-0.2-0.30.3-0.30.3-0.6-0.4-0.40.11.3
Incentive Sensitization - Breakpoint0.30.31.9-0.4-0.2-0.0-0.30.20.20.9-0.20.80.80.3-0.3-0.30.4-0.30.4-0.6-0.6-0.50.21.4
Sum of active levers in priming session hrs 5-61.21.13.1-0.7-0.7-1.2-1.0-1.2-1.10.31.00.30.3-1.21.21.1-1.11.1-1.41.41.00.3-1.4-1.8
Progressive ratio0.60.71.2-0.7-0.9-0.8-0.6-0.9-0.90.70.90.70.7-1.11.10.9-1.01.0-1.01.00.70.5-0.4-1.1
Food seeking constrained by brief footshock0.60.71.5-0.9-1.2-0.3-0.1-0.6-1.01.10.91.21.2-1.01.00.9-0.91.0-0.60.60.80.20.8-0.3
Seeking ratio, punishment vs. effort0.50.71.20.70.71.00.90.90.8-0.6-0.8-0.5-0.50.9-0.9-0.80.8-0.81.0-0.9-0.5-0.51.11.0
Retroperitoneal fat weight2.06.715.9-1.7-1.6-2.7-2.3-2.7-2.40.82.20.80.8-2.42.42.5-2.52.5-2.93.03.94.0-3.1-3.7
Reaction time number correct1.01.53.70.70.71.41.21.31.1-0.3-1.1-0.3-0.31.2-1.2-1.11.1-1.11.5-1.4-1.7-1.01.81.9
Reaction time mean minus median0.40.54.4-0.60.0-1.2-1.5-0.8-0.30.3-0.00.30.30.0-0.00.1-0.00.2-0.60.20.40.6-2.10.0
Reaction time mean minus median AUC0.60.82.6-1.2-0.8-1.3-1.6-0.9-0.71.20.51.21.2-0.40.40.5-0.50.6-0.60.40.50.7-1.40.5
Reaction time num false alarms0.40.51.7-1.0-0.6-1.0-1.3-0.7-0.51.00.41.01.0-0.30.30.3-0.30.3-0.50.30.30.5-1.20.6
Reaction time num false alarms AUC0.20.30.9-0.7-0.4-0.7-1.0-0.5-0.30.70.20.70.7-0.10.10.1-0.10.1-0.30.10.10.4-0.90.6
Reaction time trials correct on left1.01.53.70.70.71.41.21.31.1-0.3-1.1-0.3-0.31.2-1.2-1.11.1-1.11.5-1.4-1.7-1.01.81.9
Reaction time trials on left0.91.43.50.70.71.31.11.31.0-0.3-1.0-0.3-0.31.2-1.2-1.11.1-1.11.5-1.4-1.6-0.91.71.9
Reaction time mean3.75.29.1-2.3-2.0-2.8-2.9-2.6-2.31.92.01.91.9-2.22.22.2-2.12.3-2.52.32.31.7-3.0-1.8
Reaction time mean AUC3.95.28.5-2.4-2.1-2.8-2.9-2.6-2.32.02.12.02.0-2.22.22.2-2.12.3-2.52.32.21.6-2.9-1.6
Median of all reaction times5.27.29.9-2.7-2.6-3.1-3.1-3.0-2.82.22.62.32.3-2.72.72.7-2.72.8-3.02.82.71.8-3.0-2.3
Reaction time omissions1.21.63.3-1.2-1.0-1.5-1.6-1.4-1.21.01.01.01.0-1.11.11.1-1.01.2-1.31.11.81.5-1.8-0.8
Reaction time false alarm rate0.50.72.6-0.9-0.6-1.2-1.4-0.9-0.60.70.60.70.7-0.60.60.5-0.50.5-0.90.60.90.8-1.6-0.3
Reaction time premature initiation rate0.00.10.6-0.00.2-0.3-0.4-0.00.20.1-0.10.00.00.2-0.2-0.20.1-0.2-0.1-0.0-0.2-0.0-0.70.1
Reaction time premature initiations0.20.30.80.20.40.30.10.50.6-0.0-0.5-0.1-0.10.6-0.6-0.60.5-0.60.5-0.6-0.9-0.50.00.9
Std. dev. reaction times1.01.55.5-1.2-0.8-1.8-1.9-1.5-1.10.90.80.90.9-0.90.91.0-0.81.0-1.31.11.21.0-2.3-0.8
Reaction time trials completed0.91.43.50.70.71.31.11.31.0-0.3-1.0-0.3-0.31.2-1.2-1.11.1-1.11.5-1.4-1.6-0.91.71.9
Reaction time trials AUC0.71.03.50.50.41.10.91.10.8-0.0-0.8-0.0-0.01.0-1.0-0.90.9-0.91.3-1.2-1.5-0.91.61.9
Run reversals in cocaine runway, females0.40.40.6-0.7-0.7-0.6-0.5-0.6-0.70.60.70.60.6-0.60.60.7-0.70.7-0.50.60.50.5-0.2-0.3
Run reversals in cocaine runway, males0.40.42.8-0.2-0.10.50.30.60.40.6-0.30.60.60.4-0.4-0.40.4-0.40.7-0.8-1.0-0.61.01.7
Latency to leave start box in cocaine runway0.30.30.8-0.3-0.3-0.6-0.6-0.7-0.50.20.40.30.3-0.50.50.4-0.40.5-0.70.50.70.3-0.9-0.7
Latency to leave start box in cocaine runway, F0.20.20.80.60.50.20.40.00.1-0.8-0.2-0.8-0.80.1-0.1-0.10.1-0.0-0.10.10.2-0.0-0.1-0.9
Latency to leave start box in cocaine runway, M0.80.82.4-1.3-1.0-0.9-1.3-0.7-0.61.50.61.61.6-0.60.60.4-0.40.5-0.60.20.60.4-0.70.8
Std. dev. time between licks in bursts0.30.41.50.20.40.40.20.60.60.0-0.7-0.0-0.00.7-0.7-0.70.7-0.70.7-0.80.11.10.41.2
Total sessions with >9 infusions0.00.10.70.00.1-0.2-0.2-0.10.0-0.1-0.0-0.1-0.10.0-0.00.0-0.0-0.0-0.10.1-0.2-0.9-0.4-0.2
Short access day 1 total inactive lever presses0.10.20.40.50.40.50.60.50.4-0.5-0.3-0.5-0.50.4-0.4-0.30.2-0.30.4-0.3-0.10.40.60.1
Short access day 10 total inactive lever presses2.73.05.72.11.92.22.41.91.7-1.8-1.7-1.8-1.81.6-1.6-1.71.7-1.61.8-1.6-1.1-0.22.10.7
Short access day 1 total infusions1.61.73.2-1.1-1.4-1.2-0.8-1.3-1.50.91.50.90.9-1.61.61.7-1.61.6-1.51.71.0-0.3-0.7-1.8
Short access day 10 total infusions0.80.91.4-1.2-1.2-1.1-1.1-1.0-1.01.01.21.01.0-1.01.01.2-1.11.0-0.91.10.2-0.5-0.7-0.5
Short access total infusions1.11.23.3-0.7-0.9-1.1-0.9-1.2-1.20.21.20.20.2-1.21.21.4-1.31.2-1.31.60.5-0.9-1.2-1.8
Short access day 1 locomotion1.61.73.5-1.3-1.1-1.7-1.7-1.5-1.31.01.21.01.0-1.21.21.2-1.21.2-1.51.41.70.8-1.9-1.1
Short access day 10 total locomotion0.40.40.9-0.6-0.7-0.5-0.4-0.7-0.80.50.80.40.4-0.70.70.8-0.80.8-0.70.80.80.9-0.2-0.7
Short access total locomotion1.71.72.6-1.2-1.1-1.5-1.4-1.5-1.40.71.40.60.6-1.31.31.4-1.41.4-1.51.61.40.8-1.6-1.6
One hour access (0.3 mA shock)1.11.35.7-0.00.10.80.51.10.90.7-0.70.60.60.9-0.9-0.90.9-0.91.3-1.4-1.9-1.81.42.4
Compulsive drug intake3.33.34.9-2.1-2.2-1.7-1.7-1.7-1.92.21.92.22.2-1.91.91.8-1.81.9-1.61.61.81.8-0.8-0.6
One hour access (shock baseline)2.73.19.31.11.41.41.11.71.8-0.8-1.6-0.8-0.81.8-1.8-1.81.7-1.91.8-1.9-3.0-3.01.12.2
Social response proportion4.04.47.42.32.71.71.41.92.3-2.5-2.4-2.4-2.42.5-2.5-2.32.3-2.31.9-2.0-1.7-1.10.21.1
Social responses2.53.35.21.61.81.61.31.81.9-1.1-2.0-1.1-1.12.1-2.1-2.12.0-2.02.0-2.1-2.3-1.91.12.1
Social time2.43.15.4-2.2-2.0-2.1-2.3-1.8-1.72.21.72.22.2-1.61.61.7-1.71.7-1.61.61.00.8-1.8-0.3
Soleus weight2.05.912.72.42.42.42.32.42.4-2.2-2.4-2.2-2.22.4-2.4-2.42.4-2.52.4-2.4-2.8-3.61.91.7
Bone: stiffness0.61.01.60.91.10.80.51.11.3-0.7-1.1-0.7-0.71.2-1.2-1.21.2-1.21.1-1.2-0.8-0.40.21.2
Tibialis anterior weight6.421.830.45.35.54.44.24.54.9-5.3-4.9-5.3-5.34.9-4.9-4.94.9-4.84.2-4.3-4.4-5.12.22.0
Time to tail flick, vehicle, before self-admin1.41.44.2-1.1-0.9-1.7-1.6-1.4-1.10.51.10.50.5-1.11.11.2-1.11.1-1.51.40.2-0.2-2.1-1.4
Time to tail flick, vehicle, after self-admin0.30.40.9-0.8-0.6-0.8-0.9-0.6-0.50.80.40.80.8-0.40.40.4-0.40.4-0.50.30.70.4-0.80.2
Time to tail flick, test, before self-admin0.70.71.21.00.90.90.90.80.8-0.8-0.9-0.8-0.80.8-0.8-0.90.8-0.90.8-0.8-1.1-0.80.70.5
Time to tail flick, test, after self-admin0.20.21.50.30.2-0.3-0.1-0.4-0.3-0.50.1-0.5-0.5-0.30.30.2-0.20.3-0.50.50.80.5-0.7-1.2
Delta time to tail flick, vehicle, before/after SA0.20.20.9-0.5-0.6-0.0-0.2-0.1-0.30.90.20.90.9-0.30.20.1-0.20.20.0-0.20.30.10.50.8
Delta time to tail flick, test, before/after SA0.50.51.6-0.4-0.5-0.6-0.5-0.7-0.70.20.70.20.2-0.70.70.7-0.70.8-0.80.81.30.8-0.6-1.0
Tibia length3.810.618.34.14.03.33.63.23.4-4.3-3.3-4.3-4.33.1-3.1-3.13.1-3.12.7-2.6-2.3-2.81.90.3
Ambulatory time before self-admin0.20.21.3-0.5-0.2-0.8-1.0-0.4-0.20.40.10.30.3-0.10.10.1-0.10.1-0.30.20.10.3-1.10.2
Ambulatory time after self-admin0.10.10.4-0.5-0.3-0.4-0.6-0.2-0.20.50.20.50.5-0.10.10.1-0.10.1-0.10.0-0.2-0.0-0.50.4
Bone: tissue strength0.20.21.40.30.00.60.80.40.1-0.2-0.0-0.2-0.20.1-0.10.0-0.0-0.00.4-0.10.61.11.20.0
Total heroin consumption4.65.48.9-2.8-2.6-2.8-3.0-2.5-2.32.72.32.82.8-2.32.32.1-2.22.2-2.32.01.40.5-2.4-0.8
Bone: trabecular number4.46.89.73.13.03.03.02.72.7-2.9-2.7-2.9-2.92.6-2.6-2.72.7-2.62.6-2.5-1.6-1.62.31.2
Bone: trabecular spacing3.74.86.0-2.4-2.4-2.2-2.2-2.3-2.42.32.22.32.3-2.32.32.2-2.22.3-2.12.12.02.3-1.5-1.1
Bone: trabecular thickness4.85.78.02.82.72.62.62.52.5-2.7-2.5-2.7-2.72.5-2.5-2.52.5-2.42.3-2.3-1.5-1.31.91.1
Bone: trabecular tissue density0.81.28.8-0.6-0.0-1.4-1.6-0.9-0.40.10.30.10.1-0.10.20.3-0.40.3-0.80.71.73.0-2.4-0.6
Water consumed over 24 hours3.94.75.82.22.12.42.32.42.3-2.0-2.2-2.0-2.02.3-2.3-2.22.2-2.22.4-2.3-2.1-1.92.11.7
Number of responses in last shaping day0.10.10.30.30.30.50.40.40.3-0.3-0.3-0.4-0.40.4-0.4-0.30.3-0.40.5-0.4-0.00.00.50.4