Hub : Genes

Krt6a

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Eye	gene expression	Krt6a	0.6	0.15	1.5e-06	0.17	0.18	0.13	0.15	1.6e-03	1.0e-03	4.4e-03	2.6e-03
2	Eye	intron excision ratio	chr7_134711342_134729940	0.46	0.18	8.4e-05	0.13	0.18	0.15	0.16	5.7e-03	1.0e-03	2.3e-03	1.9e-03
3	Eye	intron excision ratio	chr7_134729414_134729940	0.44	0.16	5.2e-05	0.11	0.19	0.15	0.16	9.9e-03	7.8e-04	2.9e-03	1.8e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bone: apparent density	0.2	0.4	0.5	0.7	0.7	-0.6
Area under the delay curve	0.1	0.2	0.2	0.4	0.4	-0.4
BMI with tail	2.2	7.8	8.0	2.8	2.8	-2.7
BMI without tail	0.5	2.6	2.8	1.7	1.6	-1.6
Body weight	0.5	2.2	2.3	1.5	1.5	-1.4
Weight adjusted by age	0.2	0.6	0.7	0.7	0.8	-0.7
Bone surface	0.6	1.2	1.3	1.2	1.1	-1.0
Bone volume	0.8	1.6	1.8	1.3	1.3	-1.2
Breakpoint value in progressive ratio session	0.2	0.3	0.3	0.5	0.5	-0.5
Number of licking bursts	0.0	0.0	0.1	0.2	0.2	-0.2
Context. condit. distance diff. score	0.0	0.0	0.0	0.1	0.1	-0.1
Locomotion velocity, session 1	5.3	6.0	6.1	-2.5	-2.4	2.4
Locomotion distance, session 1	1.1	1.5	1.6	-1.3	-1.2	1.2
Locomotion velocity, session 2	3.4	4.1	4.2	-2.0	-2.0	2.1
Locomotion distance, session 2	1.5	2.1	2.3	-1.5	-1.4	1.4
Locomotion velocity, session 3	5.6	6.4	6.4	-2.5	-2.5	2.5
Locomotion distance, session 3	5.1	5.9	6.0	-2.4	-2.4	2.4
Stereotopy head waving bouts, day 3	2.3	2.8	2.8	1.7	1.7	-1.7
Stereotopy head waving duration, day 3	0.1	0.2	0.2	0.4	0.4	-0.4
Locomotion velocity, session 7	0.9	1.0	1.1	-1.0	-1.0	1.0
Locomotion distance, session 7	3.7	4.7	4.9	-2.2	-2.2	2.2
Stereotopy head waving bouts, day 7	4.6	5.3	5.5	2.3	2.3	-2.3
Stereotopy head waving duration, day 7	2.8	3.5	3.5	1.8	1.9	-1.9
Locomotion velocity, session 8	0.1	0.1	0.1	-0.3	-0.3	0.3
Locomotion distance, session 8	1.9	2.8	3.0	-1.7	-1.7	1.6
Degree of sensitization distance	0.4	0.5	0.5	0.6	0.7	-0.7
Degree of sensitization stereotypy	2.8	3.1	3.2	1.8	1.8	-1.8
Conditioned locomotion	0.4	0.5	0.5	-0.7	-0.6	0.7
Cocaine response after cond. corrected	0.0	0.0	0.0	-0.0	0.0	-0.0
Cocaine response after cond. not corrected	0.0	0.0	0.1	-0.3	-0.1	0.2
Cocaine response before conditioning	0.8	0.9	1.0	-1.0	-1.0	0.9
Saline control response	0.0	0.0	0.1	-0.2	-0.1	0.1
Bone: connectivity density	0.0	0.1	0.1	-0.2	-0.2	0.3
Bone: cortical apparent density	0.9	1.4	1.6	1.1	1.2	-1.3
Bone: cortical area	0.9	1.4	1.4	1.2	1.2	-1.1
Bone: cortical porosity	1.4	1.5	1.6	-1.2	-1.2	1.3
Bone: cortical porosity	1.4	1.5	1.6	-1.3	-1.2	1.3
Bone: cortical thickness	0.3	0.4	0.5	0.6	0.7	-0.6
Bone: cortical thickness	0.9	1.1	1.3	-1.1	-1.0	1.1
Bone: cortical tissue density	0.8	1.2	1.3	1.0	1.1	-1.2
Condit. Reinf. active minus inactive responses	0.3	0.4	0.4	-0.7	-0.6	0.6
Condit. Reinf. active-inactive response ratio	0.5	0.5	0.6	-0.8	-0.7	0.7
Condit. Reinf. active responses	0.8	1.1	1.3	-1.1	-1.0	1.0
Condit. Reinf. inactive responses	0.8	1.0	1.2	-1.1	-0.9	0.9
Incentive salience index mean	0.0	0.0	0.1	-0.2	-0.1	0.1
Condit. Reinf. lever presses	0.4	0.6	0.7	0.7	0.8	-0.8
Condit. Reinf. active minus inactive responses	1.0	1.5	1.6	1.2	1.2	-1.3
Condit. Reinf. active-inactive response ratio	0.3	0.5	0.5	0.7	0.7	-0.7
Condit. Reinf. active responses	1.2	1.7	1.8	1.3	1.3	-1.3
Condit. Reinf. inactive responses	0.1	0.1	0.2	0.3	0.4	-0.4
Condit. Reinf. lever presses	0.3	0.4	0.5	-0.7	-0.7	0.6
Condit. Reinf. lever reinforcers received	0.4	0.5	0.6	0.7	0.7	-0.7
Conditioned reinforcement - actives	0.0	0.0	0.1	-0.2	-0.2	0.1
Conditioned reinforcement - inactives	0.2	0.5	0.6	-0.8	-0.7	0.6
Conditioned locomotion	0.1	0.1	0.2	-0.4	-0.4	0.3
Patch foraging indifference point 0 sec	0.3	0.7	0.8	-0.9	-0.9	0.8
Patch foraging indifference point AUC	0.1	0.2	0.3	0.4	0.5	-0.5
Delay disc. indifference point, 0s delay	0.0	0.0	0.0	0.1	0.0	-0.0
Delay disc. indifference point, 16s delay	0.1	0.1	0.1	0.3	0.3	-0.3
Delay disc. indifference point, 2s delay	6.3	7.0	7.1	2.7	2.6	-2.7
Delay disc. indifference point, 24s delay	0.1	0.1	0.1	0.3	0.3	-0.3
Delay disc. indifference point, 4s delay	0.2	0.2	0.3	0.5	0.5	-0.5
Delay disc. indifference point, 8s delay	0.1	0.2	0.2	-0.4	-0.4	0.4
Indifference point function ln k	0.0	0.0	0.0	0.2	0.2	-0.1
Indifference point function log k	0.0	0.0	0.0	0.2	0.2	-0.1
Patch foraging total patch changes 0 sec	0.5	1.5	1.6	-1.2	-1.3	1.2
Patch foraging total patch changes 12 sec	0.1	0.2	0.2	-0.5	-0.4	0.3
Patch foraging total patch changes 18 sec	0.2	0.5	0.5	-0.7	-0.7	0.6
Patch foraging total patch changes 24 sec	0.0	0.0	0.0	-0.1	-0.2	0.0
Patch foraging total patch changes 6 sec	0.1	0.1	0.1	-0.2	-0.4	0.3
Patch foraging time to switch 0 sec	0.0	0.1	0.1	0.3	0.4	-0.4
Patch foraging water rate 0 sec	0.0	0.0	0.0	0.1	0.0	-0.0
Patch foraging water rate 12 sec	0.2	0.8	0.8	-0.9	-0.9	0.9
Patch foraging water rate 18 sec	0.0	0.0	0.0	-0.1	0.0	-0.0
Patch foraging water rate 24 sec	0.3	0.5	0.5	0.7	0.7	-0.7
Patch foraging water rate 6 sec	0.0	0.0	0.1	-0.2	-0.2	0.2
Seeking ratio, delayed vs. immediate footshock	0.0	0.1	0.1	-0.3	-0.2	0.2
Distance traveled before self-admin	0.0	0.0	0.0	-0.0	-0.1	0.1
Distance traveled after self-admin	1.0	1.8	1.9	-1.4	-1.4	1.3
Extensor digitorum longus weight	8.6	34.1	36.0	6.0	5.8	-5.7
Bone: elastic displacement	4.5	5.7	5.7	-2.4	-2.4	2.4
Bone: elastic work	2.9	3.8	3.9	-1.9	-1.9	2.0
Bone: endosteal estimation	0.5	1.2	1.4	1.2	1.1	-1.0
Bone: endosteal perimeter	0.9	2.3	2.5	1.6	1.5	-1.4
Epididymis fat weight	1.8	9.0	9.2	-3.0	-3.0	3.0
Delta time in closed arm before/after self-admin	0.1	0.1	0.1	0.3	0.2	-0.3
Delta time in open arm before/after self-admin	3.4	4.0	4.1	-2.0	-2.0	2.0
Diff in mean of infusions in LGA sessions	0.4	0.8	0.8	0.9	0.9	-0.9
Delay discount exponential model param	0.2	0.3	0.4	-0.6	-0.5	0.5
Extinction: sum of active levers before priming	1.2	1.8	2.2	1.5	1.3	-1.3
Active lever presses in extinction session 6	0.0	0.0	0.0	-0.1	-0.2	0.1
Bone: final force	0.5	0.8	1.1	1.0	0.9	-0.8
Bone: final moment	0.5	0.9	1.1	1.1	0.9	-0.8
Food consumed during 24 hour testing period	0.3	0.6	0.6	-0.8	-0.8	0.8
Glucose	0.4	0.6	0.6	-0.8	-0.8	0.8
Heart weight	0.1	0.1	0.1	-0.3	-0.3	0.3
Delay discount hyperbolic model param	0.4	0.6	0.6	-0.8	-0.7	0.7
Intermittent access intake day 1-15 change	0.1	0.5	0.6	-0.7	-0.8	0.7
Intermittent access intake escalation	0.0	0.2	0.2	-0.4	-0.4	0.4
Intermittent access intake escalation 2	0.2	0.3	0.4	-0.6	-0.6	0.6
Intermitt. access day 1 inactive lever presses	0.1	1.0	1.0	0.9	1.0	-1.0
Intermitt. access day 15 inactive lever presses	0.0	0.0	0.0	-0.2	-0.1	0.1
Intermitt. access escalation Index	0.7	2.3	2.4	1.5	1.4	-1.5
Intermittent access day 1 total infusions	0.0	0.0	0.0	-0.2	-0.1	0.0
Intermittent access day 15 total infusions	0.0	0.1	0.1	-0.3	-0.3	0.2
Intermittent access terminal intake (last 3 days)	0.0	0.0	0.0	-0.1	-0.1	-0.1
Intermittent access total infusions	0.0	0.0	0.1	0.1	0.1	-0.3
Intermittent access day 1 locomotion	0.0	0.0	0.1	-0.2	-0.2	0.1
Intermittent access day 15 total locomotion	0.5	1.8	1.9	-1.3	-1.4	1.4
Intermittent access total locomotion	0.3	0.3	0.4	-0.6	-0.6	0.5
Intermittent access standard deviation	0.3	1.8	1.8	-1.3	-1.4	1.3
Left kidney weight	0.0	0.1	0.2	0.4	0.4	-0.3
Right kidney weight	0.1	0.8	0.9	0.9	0.9	-0.8
Cocaine induced anxiety	0.0	0.0	0.0	0.1	-0.1	0.1
Post-drug Anxiety	0.1	0.1	0.1	-0.2	-0.3	0.3
Baseline Anxiety	0.0	0.0	0.0	-0.2	0.0	0.1
Tail length	0.3	1.4	1.5	-1.2	-1.2	1.2
Length with tail	0.1	0.4	0.4	-0.6	-0.6	0.6
Length without tail	0.0	0.0	0.1	0.2	0.2	-0.2
Times rat made contact with spout	0.4	0.5	0.5	-0.6	-0.7	0.7
Lifetime Intake	0.0	0.0	0.0	-0.1	-0.1	-0.1
Liver weight, left	0.4	0.7	1.0	1.0	0.8	-0.7
Liver weight, right	0.0	0.0	0.0	0.1	0.0	0.1
Locomotor activity	0.1	0.1	0.1	-0.3	-0.4	0.4
Locomotor testing distance	0.3	0.6	0.7	-0.7	-0.8	0.8
Locomotor testing rearing	0.2	0.6	0.7	-0.6	-0.8	0.8
Locomotion in novel chamber	2.3	3.1	3.6	1.9	1.7	-1.7
Locomotion in novel chamber post-restriction	0.1	0.3	0.3	0.6	0.4	-0.5
Fecal boli incidents, locomotor time 1	1.7	4.3	4.5	-2.1	-2.1	2.1
Change in fecal boli incidents, locomotor task	0.8	0.8	0.9	0.9	0.9	-0.9
Time >=10cm from walls, locomotor time 1	0.6	0.7	0.9	-0.9	-0.8	0.8
Bouts of movement, locomotor time 1	0.3	0.4	0.5	-0.7	-0.6	0.6
Total resting periods, locomotor time 1	1.2	1.4	1.5	-1.2	-1.1	1.1
Rest time, locomotor task time 1	0.5	0.9	0.9	-0.9	-1.0	0.9
Distance moved, locomotor task time 1	0.5	1.3	1.3	1.1	1.1	-1.2
Vertical activity count, locomotor time 1	0.4	3.0	3.1	1.7	1.7	-1.8
Time >=10cm from walls, locomotor time 2	0.1	0.3	0.3	-0.6	-0.5	0.5
Bouts of movement, locomotor time 2	0.8	2.6	2.6	1.6	1.6	-1.6
Total resting periods, locomotor time 2	0.8	3.2	3.3	1.8	1.8	-1.8
Rest time, locomotor task time 2	0.1	0.1	0.2	-0.4	-0.3	0.3
Distance moved, locomotor task time 2	0.0	0.0	0.0	0.2	0.1	-0.1
Vertical activity count, locomotor time 2	0.2	0.4	0.4	0.7	0.6	-0.6
Light reinforcement 1	0.0	0.0	0.0	-0.2	-0.2	0.1
Light reinforcement 2	0.1	0.2	0.2	-0.5	-0.4	0.3
Bone: marrow area	0.4	1.1	1.3	1.1	1.0	-1.0
Bone: maximum diameter	0.6	1.2	1.2	1.1	1.1	-1.1
Bone: maximum force	1.0	2.0	2.3	1.5	1.4	-1.3
Bone: maximum moment	1.0	1.9	2.3	1.5	1.3	-1.3
Mean time between licks in bursts	0.3	1.6	1.8	-1.2	-1.3	1.3
Mean num. licks in bursts	0.3	0.9	1.0	-0.9	-0.9	1.0
Cd content in liver	0.3	0.4	0.4	-0.6	-0.6	0.6
Co content in liver	0.2	0.2	0.3	0.5	0.5	-0.5
Cu content in liver	0.7	0.9	1.0	1.0	0.9	-0.9
Fe content in liver	0.0	0.0	0.1	-0.1	-0.3	0.2
K content in liver	0.1	0.1	0.1	0.3	0.2	-0.2
Mg content in liver	0.1	0.1	0.1	-0.2	-0.3	0.3
Mn content in liver	0.0	0.0	0.0	0.1	0.1	-0.1
Na content in liver	0.0	0.1	0.1	0.3	0.2	-0.2
Rb content in liver	0.0	0.0	0.0	-0.1	-0.2	0.1
Se content in liver	0.8	1.0	1.0	-1.0	-1.0	1.0
Sr content in liver	0.3	0.3	0.4	-0.5	-0.6	0.6
Zn content in liver	0.9	1.1	1.3	-1.1	-1.0	1.0
Bone: minimum diameter	1.1	2.2	2.3	1.5	1.5	-1.4
Time in familiar zone, hab. session 1	0.4	0.5	0.5	-0.7	-0.7	0.7
Time in novel zone, hab. session 1	1.9	2.1	2.3	1.4	1.5	-1.5
Total zone transitions, hab. session 1	0.3	0.4	0.5	0.5	0.7	-0.7
Total locomotion distance, hab. session 1	0.4	0.6	0.8	-0.9	-0.7	0.7
Locomotion velocity, hab. session 1	0.5	0.8	0.9	-0.9	-0.8	0.8
Time in familiar zone, hab. session 2	0.0	0.0	0.0	-0.0	-0.2	0.2
Time in novel zone, hab. session 2	0.4	0.4	0.5	0.6	0.7	-0.7
Total zone transitions, hab. session 2	0.3	0.4	0.5	-0.7	-0.6	0.6
Total locomotion distance, hab. session 2	0.6	0.8	0.9	-1.0	-0.8	0.9
Locomotion velocity, hab. session 2	0.9	1.2	1.3	-1.2	-1.0	1.1
Novel to familiar place preference ratio	0.8	1.0	1.1	1.0	1.0	-1.0
Novelty place preference	0.5	0.7	0.7	0.8	0.8	-0.8
Time in novel zone, NPP test	0.7	0.9	0.9	0.9	1.0	-0.9
Total zone transitions, NPP test	0.9	1.4	1.7	-1.3	-1.1	1.1
Total locomotion distance, NPP test	2.5	3.5	4.0	-2.0	-1.8	1.8
Locomotion velocity, NPP test	2.9	4.2	4.6	-2.1	-2.0	2.0
Intraocular pressure	0.5	0.9	1.0	-0.9	-1.0	0.9
Delta distance traveled before/after self-admin	4.1	4.6	4.9	-2.2	-2.1	2.1
Delta ambulatory time before/after self-admin	2.2	3.8	4.1	-2.0	-1.9	1.9
Parametrial fat weight	1.1	2.6	2.7	-1.6	-1.6	1.5
Pavlov. Cond. lever latency	1.6	2.0	2.1	-1.4	-1.4	1.5
Pavlov. Cond. magazine entry latency	2.7	3.5	3.6	1.9	1.8	-1.9
Pavlov. Cond. change in total contacts	4.1	4.4	4.4	2.1	2.1	-2.1
Pavlov. Cond. index score	4.6	5.8	6.0	2.4	2.4	-2.4
Pavlov. Cond. latency score	4.3	5.5	5.6	2.4	2.3	-2.4
Pavlov. Cond. lever contacts	1.8	2.2	2.3	1.5	1.4	-1.5
Pavlov. Cond. magazine entry number	2.0	2.5	2.6	-1.6	-1.6	1.6
Pavlov. Cond. intertrial magazine entries	2.2	2.7	2.9	-1.7	-1.6	1.6
Pavlov. Cond. lever-magazine prob. diff.	4.5	5.6	5.7	2.4	2.3	-2.4
Pavlov. Cond. response bias	1.3	1.6	1.6	1.3	1.2	-1.3
Pavlov. Cond. lever latency	1.5	2.1	2.3	1.5	1.4	-1.4
Pavlov. Cond. magazine entry latency	2.8	4.0	4.2	-2.0	-2.0	2.0
Pavlov. Cond. change in total contacts	0.4	1.0	1.1	0.9	1.0	-1.0
Pavlov. Cond. index score	1.6	2.5	2.9	-1.7	-1.6	1.5
Pavlov. Cond. latency score	1.5	2.4	2.7	-1.6	-1.5	1.5
Pavlov. Cond. lever contacts	2.1	3.0	3.5	-1.9	-1.7	1.7
Pavlov. Cond. magazine entry number	1.0	1.2	1.4	1.2	1.1	-1.1
Pavlov. Cond. intertrial magazine entries	0.5	1.1	1.2	-1.0	-1.1	1.1
Pavlov. Cond. lever-magazine prob. diff.	1.2	1.8	2.0	-1.4	-1.3	1.3
Pavlov. Cond. response bias	1.9	2.6	2.9	-1.7	-1.6	1.6
Time in closed arm before self-admin	1.0	1.8	1.8	1.3	1.4	-1.3
Time in closed arm after self-admin	3.2	3.7	3.8	1.9	1.9	-1.9
Time in open arm before self-admin	1.0	1.2	1.3	1.1	1.1	-1.1
Time in open arm after self-admin	0.9	1.0	1.0	-1.0	-0.9	1.0
Bone: periosteal estimation	0.9	2.3	2.5	1.6	1.5	-1.4
Bone: periosteal perimeter	1.9	3.8	4.0	2.0	2.0	-1.9
Bone: post-yield work	0.4	0.8	0.9	0.9	0.8	-0.8
Progressive ratio test 1 active lever presses	0.4	0.8	0.9	-0.9	-0.9	0.8
Progressive ratio test 1 breakpoint	0.6	1.0	1.1	-1.0	-1.1	0.9
Progressive ratio test 1 inactive lever presses	0.1	0.3	0.4	0.5	0.6	-0.7
Progressive ratio test 2 active lever presses	0.1	0.1	0.2	0.3	0.3	-0.4
Progressive ratio test 2 breakpoint	0.2	0.3	0.4	0.5	0.5	-0.6
Progressive ratio test 2 inactive lever presses	0.0	0.0	0.0	-0.2	-0.2	0.1
Incentive Sensitization - Responses	0.4	1.1	1.2	1.0	1.1	-1.1
Incentive Sensitization - Breakpoint	0.7	1.5	1.5	1.2	1.2	-1.2
Sum of active levers in priming session hrs 5-6	0.2	0.2	0.2	0.4	0.4	-0.4
Progressive ratio	0.0	0.0	0.0	0.1	0.0	-0.0
Food seeking constrained by brief footshock	0.0	0.0	0.0	-0.1	-0.0	-0.1
Seeking ratio, punishment vs. effort	0.0	0.0	0.0	-0.1	-0.0	-0.0
Retroperitoneal fat weight	2.9	12.9	13.2	-3.6	-3.6	3.5
Reaction time number correct	0.3	0.9	1.0	-0.9	-1.0	1.0
Reaction time mean minus median	0.0	0.0	0.0	0.1	0.1	-0.1
Reaction time mean minus median AUC	0.0	0.2	0.2	0.4	0.4	-0.4
Reaction time num false alarms	0.5	0.8	1.0	-1.0	-0.8	0.8
Reaction time num false alarms AUC	0.2	0.4	0.6	-0.8	-0.6	0.6
Reaction time trials correct on left	0.3	0.9	1.0	-0.9	-1.0	1.0
Reaction time trials on left	0.3	1.0	1.1	-1.0	-1.0	1.1
Reaction time mean	0.1	0.3	0.3	0.5	0.5	-0.5
Reaction time mean AUC	0.1	0.3	0.4	0.6	0.6	-0.6
Median of all reaction times	0.2	0.2	0.3	0.5	0.5	-0.5
Reaction time omissions	0.4	0.7	0.8	-0.9	-0.7	0.8
Reaction time false alarm rate	0.0	0.1	0.1	0.1	0.3	-0.3
Reaction time premature initiation rate	0.8	1.3	1.4	-1.2	-1.1	1.1
Reaction time premature initiations	0.8	2.4	2.4	-1.6	-1.5	1.5
Std. dev. reaction times	0.1	0.2	0.2	0.4	0.4	-0.4
Reaction time trials completed	0.3	1.0	1.1	-1.0	-1.0	1.1
Reaction time trials AUC	0.2	0.7	0.8	-0.8	-0.9	0.9
Run reversals in cocaine runway, females	0.0	0.0	0.0	-0.1	-0.1	0.2
Run reversals in cocaine runway, males	1.1	1.2	1.3	1.1	1.1	-1.1
Latency to leave start box in cocaine runway	0.2	0.2	0.2	0.5	0.5	-0.5
Latency to leave start box in cocaine runway, F	0.1	0.2	0.2	0.4	0.4	-0.4
Latency to leave start box in cocaine runway, M	0.2	0.2	0.2	0.5	0.5	-0.5
Std. dev. time between licks in bursts	1.2	2.2	2.3	-1.4	-1.5	1.5
Total sessions with >9 infusions	0.1	0.1	0.1	0.2	0.2	-0.4
Short access day 1 total inactive lever presses	0.0	0.0	0.0	-0.2	-0.2	0.1
Short access day 10 total inactive lever presses	0.0	0.3	0.3	0.5	0.6	-0.5
Short access day 1 total infusions	0.0	0.0	0.0	-0.2	-0.2	0.1
Short access day 10 total infusions	0.0	0.0	0.1	0.1	0.2	-0.3
Short access total infusions	0.0	0.1	0.1	-0.3	-0.3	0.2
Short access day 1 locomotion	0.0	0.1	0.1	0.2	0.2	-0.3
Short access day 10 total locomotion	0.0	0.1	0.1	0.2	0.3	-0.3
Short access total locomotion	0.0	0.0	0.1	0.2	0.2	-0.3
One hour access (0.3 mA shock)	1.4	1.6	1.8	1.3	1.2	-1.3
Compulsive drug intake	1.0	1.5	1.6	1.2	1.2	-1.3
One hour access (shock baseline)	0.1	0.4	0.5	0.7	0.6	-0.6
Social response proportion	1.6	2.0	2.2	-1.5	-1.4	1.4
Social responses	0.5	0.6	0.7	-0.8	-0.8	0.8
Social time	1.0	1.6	1.7	-1.2	-1.2	1.3
Soleus weight	0.0	0.0	0.0	0.2	0.1	-0.0
Bone: stiffness	3.1	5.6	5.9	2.4	2.3	-2.3
Tibialis anterior weight	11.2	38.7	39.6	6.3	6.2	-6.1
Time to tail flick, vehicle, before self-admin	0.1	0.2	0.2	0.5	0.4	-0.4
Time to tail flick, vehicle, after self-admin	0.2	0.3	0.4	0.6	0.6	-0.5
Time to tail flick, test, before self-admin	0.1	0.1	0.1	0.3	0.3	-0.3
Time to tail flick, test, after self-admin	0.8	0.8	1.0	1.0	0.9	-0.8
Delta time to tail flick, vehicle, before/after SA	0.0	0.0	0.0	-0.1	-0.1	0.2
Delta time to tail flick, test, before/after SA	0.1	0.1	0.1	0.4	0.4	-0.3
Tibia length	0.0	0.1	0.1	0.3	0.3	-0.3
Ambulatory time before self-admin	0.0	0.1	0.1	-0.3	-0.4	0.3
Ambulatory time after self-admin	1.1	1.8	1.9	-1.4	-1.4	1.3
Bone: tissue strength	1.6	1.6	1.8	1.3	1.2	-1.2
Total heroin consumption	0.1	0.1	0.1	0.4	0.2	-0.3
Bone: trabecular number	0.0	0.1	0.1	-0.2	-0.3	0.3
Bone: trabecular spacing	0.4	0.5	0.6	0.7	0.7	-0.8
Bone: trabecular thickness	0.1	0.1	0.2	0.4	0.4	-0.4
Bone: trabecular tissue density	1.7	3.0	3.3	1.6	1.8	-1.8
Water consumed over 24 hours	0.3	0.6	0.6	-0.7	-0.8	0.8
Number of responses in last shaping day	0.4	0.6	0.7	-0.8	-0.6	0.7