Hub : Genes

Krt6a

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Eye	intron excision ratio	chr7_132832634_132851232	0.45	0.19	2.1e-04	0.02	0.15	0.05	0.07	1.8e-01	2.5e-03	5.5e-02	3.0e-02
2	Eye	intron excision ratio	chr7_132850706_132851232	0.43	0.18	1.9e-04	0.05	0.15	0.07	0.09	5.6e-02	2.7e-03	2.9e-02	1.9e-02
3	Eye	gene expression	Krt6a	0.55	0.17	1.7e-05	0.16	0.14	0.04	0.14	1.7e-03	3.9e-03	8.1e-02	4.3e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bone: apparent density	0.1	0.2	0.3	0.6	-0.5	-0.3
Area under the delay curve	0.3	0.3	0.5	0.5	-0.5	-0.7
BMI with tail	2.8	9.1	9.9	3.0	-2.9	-3.1
BMI without tail	0.4	0.8	1.1	0.8	-0.7	-1.0
Body weight	0.7	2.9	3.7	1.6	-1.5	-1.9
Weight adjusted by age	0.3	0.3	0.7	0.4	-0.4	-0.8
Bone surface	0.5	0.8	1.2	1.1	-1.0	-0.5
Bone volume	0.6	1.0	1.3	1.1	-1.1	-0.7
Breakpoint value in progressive ratio session	0.2	0.2	0.3	0.5	-0.6	0.1
Number of licking bursts	0.0	0.0	0.0	0.2	-0.2	-0.1
Context. condit. distance diff. score	0.0	0.0	0.0	0.1	-0.1	0.1
Locomotion velocity, session 1	5.3	5.8	6.2	-2.5	2.4	2.3
Locomotion distance, session 1	0.9	1.2	1.4	-1.2	1.2	0.9
Locomotion velocity, session 2	3.3	3.8	4.2	-2.0	2.0	1.8
Locomotion distance, session 2	1.2	1.6	2.0	-1.4	1.4	1.0
Locomotion velocity, session 3	5.8	6.8	6.9	-2.6	2.6	2.6
Locomotion distance, session 3	5.3	5.8	5.9	-2.4	2.4	2.4
Stereotopy head waving bouts, day 3	1.8	2.1	2.2	1.5	-1.5	-1.4
Stereotopy head waving duration, day 3	0.0	0.0	0.1	0.2	-0.2	-0.2
Locomotion velocity, session 7	1.2	1.3	1.5	-1.2	1.1	1.2
Locomotion distance, session 7	3.9	4.9	5.0	-2.2	2.2	2.2
Stereotopy head waving bouts, day 7	3.5	4.0	4.0	2.0	-2.0	-2.0
Stereotopy head waving duration, day 7	3.1	3.7	4.0	2.0	-2.0	-1.8
Locomotion velocity, session 8	0.1	0.2	0.2	-0.4	0.3	0.5
Locomotion distance, session 8	1.6	2.3	2.5	-1.6	1.5	1.5
Degree of sensitization distance	0.5	0.5	0.6	0.7	-0.7	-0.8
Degree of sensitization stereotypy	3.0	3.3	3.5	1.9	-1.9	-1.7
Conditioned locomotion	0.2	0.3	0.4	-0.6	0.6	0.4
Cocaine response after cond. corrected	0.1	0.1	0.2	0.1	-0.1	-0.5
Cocaine response after cond. not corrected	0.0	0.0	0.0	-0.1	0.1	-0.1
Cocaine response before conditioning	1.2	1.4	1.9	-1.1	1.1	1.4
Saline control response	0.0	0.0	0.0	-0.1	0.1	0.1
Bone: connectivity density	0.1	0.1	0.2	-0.2	0.3	0.4
Bone: cortical apparent density	1.2	1.6	2.3	1.1	-1.1	-1.5
Bone: cortical area	0.8	1.2	1.4	1.2	-1.1	-0.9
Bone: cortical porosity	1.6	1.7	1.9	-1.2	1.3	1.4
Bone: cortical porosity	1.5	1.6	1.7	-1.2	1.2	1.3
Bone: cortical thickness	0.2	0.3	0.3	0.5	-0.5	-0.6
Bone: cortical thickness	0.6	0.7	0.9	-0.9	1.0	0.5
Bone: cortical tissue density	0.9	1.2	1.9	0.9	-1.0	-1.4
Condit. Reinf. active minus inactive responses	0.2	0.3	0.3	-0.5	0.5	0.5
Condit. Reinf. active-inactive response ratio	0.4	0.4	0.4	-0.6	0.7	0.7
Condit. Reinf. active responses	0.7	0.8	0.9	-0.9	1.0	0.8
Condit. Reinf. inactive responses	0.7	0.9	1.0	-1.0	1.0	0.7
Incentive salience index mean	0.0	0.0	0.0	-0.1	0.1	0.1
Condit. Reinf. lever presses	0.6	0.8	1.0	0.9	-0.9	-1.0
Condit. Reinf. active minus inactive responses	1.3	1.7	1.7	1.3	-1.3	-1.3
Condit. Reinf. active-inactive response ratio	0.6	0.7	0.7	0.8	-0.8	-0.8
Condit. Reinf. active responses	1.2	1.7	1.8	1.3	-1.3	-1.2
Condit. Reinf. inactive responses	0.1	0.1	0.1	0.3	-0.3	-0.3
Condit. Reinf. lever presses	0.3	0.4	0.4	-0.6	0.6	0.7
Condit. Reinf. lever reinforcers received	0.4	0.5	0.6	0.7	-0.7	-0.7
Conditioned reinforcement - actives	0.2	0.2	0.3	0.4	-0.5	-0.1
Conditioned reinforcement - inactives	0.0	0.0	0.0	-0.1	0.1	-0.1
Conditioned locomotion	0.1	0.1	0.4	-0.2	0.1	0.6
Patch foraging indifference point 0 sec	0.3	0.6	0.6	-0.8	0.7	0.8
Patch foraging indifference point AUC	0.4	0.5	0.8	0.5	-0.6	-0.9
Delay disc. indifference point, 0s delay	0.1	0.2	0.4	0.2	-0.2	-0.6
Delay disc. indifference point, 16s delay	0.3	0.3	0.6	0.5	-0.4	-0.8
Delay disc. indifference point, 2s delay	6.6	7.3	7.5	2.7	-2.7	-2.7
Delay disc. indifference point, 24s delay	0.2	0.2	0.2	0.4	-0.4	-0.4
Delay disc. indifference point, 4s delay	0.3	0.3	0.5	0.5	-0.5	-0.7
Delay disc. indifference point, 8s delay	0.1	0.1	0.1	-0.2	0.3	0.3
Indifference point function ln k	0.0	0.0	0.1	0.2	-0.1	0.2
Indifference point function log k	0.0	0.0	0.1	0.2	-0.1	0.2
Patch foraging total patch changes 0 sec	0.9	1.4	1.5	-1.2	1.1	1.2
Patch foraging total patch changes 12 sec	0.1	0.1	0.2	-0.4	0.3	0.2
Patch foraging total patch changes 18 sec	0.4	0.5	0.6	-0.8	0.7	0.7
Patch foraging total patch changes 24 sec	0.0	0.0	0.1	-0.0	-0.0	0.3
Patch foraging total patch changes 6 sec	0.1	0.1	0.2	-0.4	0.3	0.1
Patch foraging time to switch 0 sec	0.1	0.2	0.4	0.4	-0.4	-0.6
Patch foraging water rate 0 sec	0.0	0.0	0.1	0.0	0.0	0.3
Patch foraging water rate 12 sec	0.7	1.1	2.0	-0.8	0.8	1.4
Patch foraging water rate 18 sec	0.0	0.0	0.1	0.1	-0.1	0.4
Patch foraging water rate 24 sec	0.2	0.3	0.4	0.7	-0.6	-0.3
Patch foraging water rate 6 sec	0.2	0.3	0.9	-0.2	0.2	1.0
Seeking ratio, delayed vs. immediate footshock	0.0	0.1	0.1	0.1	-0.1	-0.4
Distance traveled before self-admin	0.0	0.0	0.0	0.0	-0.0	-0.0
Distance traveled after self-admin	0.8	0.8	1.6	-0.7	0.7	1.3
Extensor digitorum longus weight	8.1	31.8	33.3	5.8	-5.7	-5.5
Bone: elastic displacement	5.8	6.6	6.8	-2.6	2.6	2.5
Bone: elastic work	3.0	3.9	4.1	-2.0	2.0	1.9
Bone: endosteal estimation	0.5	1.1	1.5	1.2	-1.1	-0.6
Bone: endosteal perimeter	1.1	2.2	2.8	1.7	-1.6	-1.2
Epididymis fat weight	3.0	6.9	7.5	-2.6	2.7	2.5
Delta time in closed arm before/after self-admin	0.1	0.1	0.2	0.3	-0.3	0.4
Delta time in open arm before/after self-admin	5.0	4.8	5.1	-2.3	2.3	2.0
Diff in mean of infusions in LGA sessions	1.0	1.1	1.2	1.1	-1.0	-1.1
Delay discount exponential model param	0.4	0.4	0.6	-0.6	0.6	0.8
Extinction: sum of active levers before priming	1.0	1.0	1.3	1.1	-1.1	-0.8
Active lever presses in extinction session 6	0.1	0.1	0.2	0.2	-0.2	-0.4
Bone: final force	0.2	0.4	0.6	0.8	-0.7	-0.4
Bone: final moment	0.2	0.4	0.6	0.8	-0.7	-0.3
Food consumed during 24 hour testing period	0.6	0.8	1.2	-0.7	0.8	1.1
Glucose	0.1	0.2	0.2	-0.4	0.4	0.3
Heart weight	0.1	0.1	0.2	0.1	-0.1	-0.4
Delay discount hyperbolic model param	0.8	0.9	1.1	-0.9	0.9	1.1
Intermittent access intake day 1-15 change	0.5	0.5	0.5	-0.7	0.7	0.7
Intermittent access intake escalation	0.4	0.4	0.4	-0.6	0.6	0.7
Intermittent access intake escalation 2	0.4	0.4	0.7	-0.5	0.5	0.8
Intermitt. access day 1 inactive lever presses	0.1	0.1	0.1	0.3	-0.3	-0.1
Intermitt. access day 15 inactive lever presses	0.7	0.8	1.2	-0.8	0.8	1.1
Intermitt. access escalation Index	1.3	1.2	1.2	1.0	-1.1	-1.1
Intermittent access day 1 total infusions	0.0	0.0	0.0	0.1	-0.2	-0.2
Intermittent access day 15 total infusions	0.1	0.1	0.2	-0.5	0.4	0.2
Intermittent access terminal intake (last 3 days)	0.0	0.0	0.1	0.2	-0.3	-0.2
Intermittent access total infusions	0.1	0.1	0.2	0.3	-0.4	-0.4
Intermittent access day 1 locomotion	0.2	0.2	0.3	-0.5	0.4	0.5
Intermittent access day 15 total locomotion	0.9	1.0	1.0	-1.0	1.0	0.9
Intermittent access total locomotion	0.2	0.3	0.5	-0.5	0.4	0.7
Intermittent access standard deviation	0.7	0.8	1.1	-1.1	1.1	0.3
Left kidney weight	0.2	0.5	0.6	0.7	-0.6	-0.8
Right kidney weight	0.6	1.6	2.2	1.2	-1.1	-1.5
Cocaine induced anxiety	0.1	0.1	0.3	-0.1	0.1	0.5
Post-drug Anxiety	0.6	0.7	0.8	0.9	-0.9	-0.7
Baseline Anxiety	0.2	0.2	0.3	0.4	-0.4	-0.5
Tail length	0.4	1.2	1.3	-1.2	1.1	0.9
Length with tail	0.1	0.2	0.3	-0.5	0.6	0.3
Length without tail	0.1	0.3	0.3	0.5	-0.5	-0.6
Times rat made contact with spout	0.6	0.7	1.1	-0.7	0.8	1.0
Lifetime Intake	0.0	0.0	0.0	-0.0	-0.1	0.0
Liver weight, left	0.1	0.2	0.4	-0.3	0.3	0.7
Liver weight, right	0.1	0.2	0.3	-0.3	0.3	0.5
Locomotor activity	0.1	0.1	0.1	-0.3	0.3	0.3
Locomotor testing distance	0.8	1.3	1.3	-1.1	1.1	1.1
Locomotor testing rearing	0.5	0.8	0.8	-0.9	0.9	0.8
Locomotion in novel chamber	1.9	2.3	3.0	1.7	-1.7	-1.1
Locomotion in novel chamber post-restriction	0.3	0.3	0.5	0.6	-0.7	-0.2
Fecal boli incidents, locomotor time 1	3.8	4.2	4.6	-2.2	2.1	1.8
Change in fecal boli incidents, locomotor task	1.2	1.1	1.3	1.1	-1.1	-0.9
Time >=10cm from walls, locomotor time 1	0.7	0.7	1.3	-0.7	0.7	1.1
Bouts of movement, locomotor time 1	0.2	0.2	0.3	-0.5	0.5	0.0
Total resting periods, locomotor time 1	0.7	0.7	1.1	-1.0	1.0	0.3
Rest time, locomotor task time 1	0.5	0.5	0.8	-0.9	0.9	0.3
Distance moved, locomotor task time 1	0.8	0.8	1.2	1.1	-1.1	-0.3
Vertical activity count, locomotor time 1	2.2	2.3	3.0	1.7	-1.7	-0.9
Time >=10cm from walls, locomotor time 2	0.2	0.2	0.3	-0.5	0.5	0.4
Bouts of movement, locomotor time 2	2.0	2.2	2.2	1.5	-1.5	-1.5
Total resting periods, locomotor time 2	2.9	3.1	3.4	1.7	-1.7	-1.8
Rest time, locomotor task time 2	0.1	0.1	0.1	-0.3	0.2	-0.3
Distance moved, locomotor task time 2	0.0	0.0	0.0	0.1	-0.1	-0.1
Vertical activity count, locomotor time 2	0.1	0.1	0.2	0.4	-0.4	-0.1
Light reinforcement 1	0.0	0.0	0.0	-0.1	0.0	-0.0
Light reinforcement 2	0.0	0.1	0.1	-0.3	0.3	0.0
Bone: marrow area	0.5	1.1	1.5	1.2	-1.1	-0.6
Bone: maximum diameter	0.6	1.1	1.4	1.2	-1.1	-0.8
Bone: maximum force	0.8	1.3	1.7	1.3	-1.2	-0.8
Bone: maximum moment	0.7	1.2	1.7	1.3	-1.2	-0.8
Mean time between licks in bursts	1.3	1.8	2.1	-1.5	1.4	1.2
Mean num. licks in bursts	0.8	1.0	1.1	-0.9	1.0	1.0
Cd content in liver	0.3	0.3	0.4	-0.5	0.5	0.6
Co content in liver	0.0	0.0	0.1	0.1	-0.1	0.2
Cu content in liver	0.7	0.8	1.2	1.1	-1.1	-0.2
Fe content in liver	0.1	0.1	0.2	-0.4	0.4	0.4
K content in liver	0.2	0.2	0.3	-0.4	0.4	0.6
Mg content in liver	0.4	0.4	0.6	-0.6	0.5	0.8
Mn content in liver	0.0	0.0	0.0	-0.0	0.0	-0.1
Na content in liver	0.0	0.0	0.0	0.0	-0.1	0.0
Rb content in liver	0.2	0.2	0.6	-0.2	0.2	0.8
Se content in liver	0.4	0.5	0.7	-0.8	0.8	0.5
Sr content in liver	1.5	1.4	1.5	-1.2	1.2	1.2
Zn content in liver	1.6	1.8	1.9	-1.4	1.3	1.4
Bone: minimum diameter	1.0	1.9	2.4	1.6	-1.5	-1.1
Time in familiar zone, hab. session 1	0.6	0.5	0.6	-0.8	0.8	0.6
Time in novel zone, hab. session 1	2.4	2.3	2.5	1.6	-1.6	-1.4
Total zone transitions, hab. session 1	0.3	0.5	0.7	0.6	-0.6	-0.8
Total locomotion distance, hab. session 1	0.3	0.4	0.6	-0.8	0.7	0.4
Locomotion velocity, hab. session 1	0.4	0.6	0.8	-0.9	0.9	0.5
Time in familiar zone, hab. session 2	0.1	0.1	0.3	-0.1	0.2	0.5
Time in novel zone, hab. session 2	0.6	0.6	0.8	0.6	-0.7	-0.9
Total zone transitions, hab. session 2	0.3	0.3	0.4	-0.7	0.6	0.5
Total locomotion distance, hab. session 2	0.4	0.5	0.7	-0.8	0.8	0.4
Locomotion velocity, hab. session 2	0.7	0.9	1.1	-1.1	1.1	0.6
Novel to familiar place preference ratio	1.1	1.2	1.3	1.1	-1.0	-1.2
Novelty place preference	0.8	0.8	0.9	0.9	-0.8	-0.9
Time in novel zone, NPP test	1.0	1.0	1.1	1.0	-1.0	-1.0
Total zone transitions, NPP test	0.7	1.1	1.4	-1.2	1.1	0.8
Total locomotion distance, NPP test	2.0	2.8	3.5	-1.9	1.8	1.2
Locomotion velocity, NPP test	2.3	3.3	4.1	-2.0	2.0	1.4
Intraocular pressure	0.8	1.1	1.7	-0.9	0.8	1.3
Delta distance traveled before/after self-admin	2.7	2.9	4.1	-1.5	1.5	2.0
Delta ambulatory time before/after self-admin	2.4	2.7	4.0	-1.4	1.4	2.0
Parametrial fat weight	3.5	6.8	7.2	-2.7	2.7	2.5
Pavlov. Cond. lever latency	1.6	2.1	2.3	-1.5	1.5	1.3
Pavlov. Cond. magazine entry latency	3.5	4.5	4.9	2.2	-2.2	-2.0
Pavlov. Cond. change in total contacts	3.8	4.1	4.5	2.1	-2.1	-1.8
Pavlov. Cond. index score	4.5	5.7	6.2	2.5	-2.5	-2.2
Pavlov. Cond. latency score	4.1	5.3	5.8	2.4	-2.4	-2.1
Pavlov. Cond. lever contacts	1.6	1.9	2.1	1.4	-1.5	-1.2
Pavlov. Cond. magazine entry number	1.7	2.1	2.5	-1.6	1.6	1.2
Pavlov. Cond. intertrial magazine entries	2.2	2.7	3.0	-1.7	1.7	1.5
Pavlov. Cond. lever-magazine prob. diff.	4.4	5.5	6.0	2.4	-2.4	-2.1
Pavlov. Cond. response bias	1.7	2.0	2.3	1.5	-1.5	-1.2
Pavlov. Cond. lever latency	1.1	1.5	1.5	1.2	-1.2	-1.2
Pavlov. Cond. magazine entry latency	2.6	3.0	3.3	-1.8	1.8	1.5
Pavlov. Cond. change in total contacts	1.0	1.4	1.4	1.2	-1.2	-1.2
Pavlov. Cond. index score	1.6	2.1	2.3	-1.5	1.5	1.3
Pavlov. Cond. latency score	1.4	1.7	1.9	-1.4	1.4	1.2
Pavlov. Cond. lever contacts	2.0	2.8	2.8	-1.7	1.7	1.7
Pavlov. Cond. magazine entry number	0.6	0.8	0.9	0.9	-0.9	-0.7
Pavlov. Cond. intertrial magazine entries	1.0	1.3	1.5	-1.1	1.1	1.2
Pavlov. Cond. lever-magazine prob. diff.	1.0	1.2	1.4	-1.2	1.2	1.0
Pavlov. Cond. response bias	2.0	2.7	2.7	-1.6	1.6	1.6
Time in closed arm before self-admin	0.7	0.8	1.5	0.7	-0.7	-1.2
Time in closed arm after self-admin	2.2	2.3	2.7	1.6	-1.6	-1.2
Time in open arm before self-admin	2.4	2.6	3.1	1.7	-1.8	-1.3
Time in open arm after self-admin	0.4	0.4	0.5	-0.7	0.7	0.5
Bone: periosteal estimation	0.8	1.7	2.3	1.5	-1.4	-0.9
Bone: periosteal perimeter	2.3	3.9	4.4	2.1	-2.0	-1.7
Bone: post-yield work	0.6	0.8	1.1	1.0	-1.0	-0.6
Progressive ratio test 1 active lever presses	0.5	0.5	0.7	-0.8	0.7	0.6
Progressive ratio test 1 breakpoint	0.3	0.3	0.4	-0.7	0.5	0.5
Progressive ratio test 1 inactive lever presses	0.0	0.0	0.0	0.0	-0.1	0.1
Progressive ratio test 2 active lever presses	0.0	0.0	0.0	0.1	-0.1	0.0
Progressive ratio test 2 breakpoint	0.0	0.0	0.0	0.2	-0.2	-0.1
Progressive ratio test 2 inactive lever presses	0.0	0.1	0.1	-0.2	0.2	0.2
Incentive Sensitization - Responses	0.4	0.5	0.5	0.7	-0.7	-0.6
Incentive Sensitization - Breakpoint	0.8	0.8	0.9	0.9	-0.9	-0.8
Sum of active levers in priming session hrs 5-6	0.2	0.2	0.3	0.5	-0.5	-0.5
Progressive ratio	0.0	0.0	0.0	-0.1	0.1	0.1
Food seeking constrained by brief footshock	0.0	0.0	0.0	0.1	-0.2	-0.2
Seeking ratio, punishment vs. effort	0.0	0.0	0.0	0.0	-0.1	-0.1
Retroperitoneal fat weight	1.7	5.6	6.3	-2.5	2.5	2.1
Reaction time number correct	0.9	1.2	1.9	-0.9	1.0	1.4
Reaction time mean minus median	0.1	0.1	0.2	0.0	-0.0	-0.4
Reaction time mean minus median AUC	0.2	0.2	0.5	0.3	-0.3	-0.7
Reaction time num false alarms	0.3	0.4	0.5	-0.7	0.6	0.7
Reaction time num false alarms AUC	0.1	0.1	0.2	-0.4	0.4	0.3
Reaction time trials correct on left	0.9	1.2	1.9	-0.9	1.0	1.4
Reaction time trials on left	0.9	1.3	2.0	-1.0	1.0	1.4
Reaction time mean	0.2	0.3	0.5	0.4	-0.4	-0.7
Reaction time mean AUC	0.2	0.3	0.5	0.5	-0.4	-0.7
Median of all reaction times	0.2	0.2	0.4	0.4	-0.4	-0.6
Reaction time omissions	0.9	1.2	1.3	-1.2	1.2	1.0
Reaction time false alarm rate	0.2	0.3	0.4	0.4	-0.5	-0.6
Reaction time premature initiation rate	0.9	1.2	1.4	-1.2	1.1	1.0
Reaction time premature initiations	1.8	2.5	2.7	-1.5	1.6	1.6
Std. dev. reaction times	0.2	0.2	0.5	0.3	-0.3	-0.7
Reaction time trials completed	0.9	1.3	2.0	-1.0	1.0	1.4
Reaction time trials AUC	0.7	1.0	1.6	-0.8	0.8	1.3
Run reversals in cocaine runway, females	0.1	0.1	0.2	0.1	-0.1	-0.4
Run reversals in cocaine runway, males	1.6	1.5	2.5	1.1	-1.0	-1.6
Latency to leave start box in cocaine runway	0.4	0.4	0.4	0.6	-0.6	-0.6
Latency to leave start box in cocaine runway, F	0.3	0.3	0.5	0.4	-0.5	-0.7
Latency to leave start box in cocaine runway, M	0.5	0.5	0.7	0.8	-0.8	-0.3
Std. dev. time between licks in bursts	1.8	2.2	2.3	-1.5	1.5	1.4
Total sessions with >9 infusions	0.3	0.4	0.5	0.7	-0.7	-0.4
Short access day 1 total inactive lever presses	0.0	0.0	0.1	-0.2	0.1	0.3
Short access day 10 total inactive lever presses	0.1	0.1	0.2	-0.0	0.1	0.5
Short access day 1 total infusions	0.0	0.0	0.0	0.0	-0.0	-0.2
Short access day 10 total infusions	0.0	0.0	0.0	-0.2	0.1	0.1
Short access total infusions	0.1	0.1	0.1	-0.3	0.2	0.3
Short access day 1 locomotion	0.0	0.0	0.0	-0.2	0.2	0.1
Short access day 10 total locomotion	0.0	0.0	0.1	-0.1	0.1	-0.3
Short access total locomotion	0.0	0.0	0.1	-0.1	0.1	-0.3
One hour access (0.3 mA shock)	2.0	2.4	2.9	1.7	-1.7	-1.2
Compulsive drug intake	1.8	1.8	2.3	1.5	-1.5	-0.8
One hour access (shock baseline)	1.0	1.2	1.3	1.0	-1.1	-1.1
Social response proportion	1.4	1.5	1.6	-1.3	1.3	1.1
Social responses	0.4	0.5	0.6	-0.8	0.8	0.3
Social time	0.9	1.2	1.4	-1.1	1.2	1.0
Soleus weight	0.0	0.0	0.1	0.3	-0.2	-0.1
Bone: stiffness	2.6	4.0	4.8	2.2	-2.1	-1.7
Tibialis anterior weight	10.9	37.4	37.8	6.1	-6.1	-6.2
Time to tail flick, vehicle, before self-admin	0.4	0.4	0.8	0.5	-0.5	-0.9
Time to tail flick, vehicle, after self-admin	0.1	0.1	0.2	0.4	-0.3	0.0
Time to tail flick, test, before self-admin	0.6	0.5	1.3	0.4	-0.4	-1.1
Time to tail flick, test, after self-admin	0.3	0.3	0.4	0.6	-0.6	-0.4
Delta time to tail flick, vehicle, before/after SA	0.3	0.3	0.7	-0.3	0.3	0.9
Delta time to tail flick, test, before/after SA	0.1	0.1	0.2	0.4	-0.4	0.2
Tibia length	0.0	0.1	0.2	0.4	-0.3	-0.0
Ambulatory time before self-admin	0.0	0.0	0.0	-0.2	0.1	0.2
Ambulatory time after self-admin	1.4	1.5	2.9	-0.9	0.9	1.7
Bone: tissue strength	1.3	1.3	1.5	1.2	-1.2	-1.0
Total heroin consumption	0.0	0.0	0.0	0.2	-0.1	0.0
Bone: trabecular number	0.1	0.2	0.3	-0.4	0.5	0.5
Bone: trabecular spacing	0.5	0.6	0.8	0.8	-0.9	-0.6
Bone: trabecular thickness	0.0	0.0	0.1	0.1	-0.1	-0.2
Bone: trabecular tissue density	2.0	2.9	2.9	1.7	-1.7	-1.7
Water consumed over 24 hours	0.8	1.0	1.4	-0.9	0.9	1.2
Number of responses in last shaping day	0.5	0.5	0.7	-0.8	0.8	0.4