Hub : Genes

Tnrc6a

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Brain gene expression Tnrc6a 0.26 0.12 9.0e-13 0.1 0.12 0.12 0.13 1.4e-09 3.3e-11 1.8e-11 6.8e-12
2 PL gene expression Tnrc6a 0.08 0.04 5.2e-11 0.06 0.09 0.07 0.07 2.8e-07 5.1e-10 1.3e-08 5.5e-08
3 NAcc gene expression Tnrc6a 0.02 0.01 2.5e-03 0 0.01 0.01 0.01 1.2e-01 3.0e-02 1.2e-02 2.6e-02
4 Adipose mRNA stability Tnrc6a 0.24 0.12 3.7e-11 0.05 0.08 0.08 0.08 1.3e-06 1.4e-09 4.5e-09 4.7e-09
5 PL intron excision ratio chr1_187020878_187097468 0.04 0.03 6.1e-03 0 0.01 -0 -0 1.6e-01 6.5e-02 4.4e-01 4.2e-01
6 Brain isoform ratio XM_063263194.1 0.04 0.03 8.5e-03 0.01 -0 0 0 6.5e-02 4.2e-01 3.6e-01 1.1e-01
7 BLA isoform ratio XM_063263194.1 0.06 0.04 7.4e-03 0.03 0.03 0.01 0.02 1.0e-02 1.7e-02 9.6e-02 2.1e-02
8 pVTA gene expression Tnrc6a 0.05 0.03 5.2e-04 0.04 0.04 0.04 0.04 2.4e-04 7.3e-04 2.8e-04 5.0e-04
9 Brain mRNA stability Tnrc6a 0.2 0.09 2.9e-10 0.11 0.12 0.12 0.12 2.4e-10 4.0e-11 2.6e-11 9.9e-12
10 PL intron excision ratio chr1_187132291_187133076 0.04 0.03 1.1e-03 0.01 0.01 0 0.01 1.5e-02 7.9e-03 1.0e-01 5.7e-02
11 PL intron excision ratio chr1_187132291_187132771 0.03 0.02 6.4e-03 -0 -0 -0 -0 6.8e-01 5.4e-01 7.9e-01 1.0e+00
12 PL intron excision ratio chr1_187105005_187114341 0.17 0.14 8.8e-03 -0 0.01 0.01 0.01 5.9e-01 2.6e-02 5.7e-02 3.1e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12
Bone: apparent density0.50.82.00.70.90.41.10.9-1.0-1.4-0.01.10.7-0.7-1.1
Area under the delay curve0.20.20.6-0.2-0.10.20.20.4-0.40.1-0.40.40.7-0.7-0.8
BMI with tail1.96.711.82.92.62.73.03.3-3.4-1.60.13.12.7-2.6-0.7
BMI without tail2.88.413.53.43.13.13.33.5-3.7-2.3-0.13.52.8-2.6-1.1
Body weight1.56.516.74.13.63.63.02.7-2.6-1.61.82.01.1-0.8-0.3
Weight adjusted by age0.10.10.60.30.1-0.20.10.3-0.10.1-0.40.20.7-0.8-0.0
Bone surface0.61.13.21.31.81.21.60.6-0.7-1.10.50.60.6-0.6-1.0
Bone volume0.91.63.31.51.81.31.71.0-1.0-1.60.21.10.9-0.9-1.2
Breakpoint value in progressive ratio session0.20.30.6-0.5-0.5-0.4-0.40.10.7-0.7-0.6-0.5-0.20.3-0.8
Number of licking bursts2.74.410.7-3.3-3.1-3.1-1.5-0.50.71.2-2.90.01.7-2.0-1.8
Context. condit. distance diff. score0.60.71.9-0.9-1.0-1.0-0.70.10.11.4-1.40.10.8-0.9-0.7
Locomotion velocity, session 10.20.20.70.10.50.20.30.1-0.1-0.8-0.50.30.3-0.3-0.8
Locomotion distance, session 10.10.10.30.30.40.50.30.5-0.2-0.30.30.20.4-0.4-0.4
Locomotion velocity, session 20.30.31.60.30.30.30.50.6-0.1-0.4-0.10.00.8-0.8-1.3
Locomotion distance, session 20.30.50.70.70.90.70.80.5-0.9-0.70.70.70.4-0.40.2
Locomotion velocity, session 30.91.03.21.51.61.81.30.5-0.9-0.31.30.60.00.10.3
Locomotion distance, session 30.20.20.50.40.70.70.5-0.4-0.00.20.7-0.1-0.10.1-0.3
Stereotopy head waving bouts, day 30.40.43.7-0.20.2-0.00.30.3-0.5-1.9-0.70.7-0.20.30.2
Stereotopy head waving duration, day 30.40.53.50.10.60.40.80.6-0.6-1.9-0.00.70.10.0-0.1
Locomotion velocity, session 71.61.73.10.90.81.1-0.8-1.41.01.71.4-0.9-1.71.71.8
Locomotion distance, session 70.40.52.2-0.7-0.6-1.0-0.9-0.90.81.5-0.1-0.4-0.1-0.10.3
Stereotopy head waving bouts, day 70.20.20.60.40.60.80.2-0.00.0-0.40.4-0.1-0.50.60.2
Stereotopy head waving duration, day 70.60.72.61.11.41.60.80.2-0.5-0.80.70.3-0.40.50.5
Locomotion velocity, session 80.20.20.50.40.40.20.50.4-0.7-0.60.00.60.2-0.2-0.6
Locomotion distance, session 80.20.30.9-0.3-0.2-0.30.10.3-0.40.7-0.30.50.8-0.9-0.5
Degree of sensitization distance0.80.92.6-1.1-1.5-1.6-0.90.40.00.5-1.30.40.7-0.7-0.0
Degree of sensitization stereotypy0.40.41.30.80.91.10.1-0.40.10.30.7-0.4-0.60.70.6
Conditioned locomotion0.50.51.40.10.2-0.0-0.5-1.10.30.51.0-0.6-1.01.01.2
Cocaine response after cond. corrected0.60.72.2-1.4-1.5-1.3-0.9-0.10.40.5-1.1-0.20.4-0.5-0.6
Cocaine response after cond. not corrected0.00.00.20.0-0.30.1-0.40.30.20.30.0-0.1-0.10.1-0.2
Cocaine response before conditioning2.02.47.62.82.52.71.20.7-0.4-0.51.90.0-0.70.90.4
Saline control response0.81.14.3-0.6-0.5-0.80.20.7-0.5-1.6-1.40.71.0-1.0-2.1
Bone: connectivity density0.20.30.6-0.10.50.10.70.3-0.7-0.8-0.10.80.5-0.5-0.7
Bone: cortical apparent density0.60.82.0-1.2-1.2-1.4-0.4-0.10.60.4-1.1-0.30.7-0.8-1.0
Bone: cortical area2.64.17.62.42.52.12.82.1-2.0-1.90.51.71.8-1.7-1.7
Bone: cortical porosity2.52.79.12.22.22.71.2-0.1-0.10.33.0-0.7-1.11.21.3
Bone: cortical porosity2.52.78.02.02.02.50.7-0.50.40.32.8-1.1-1.61.71.5
Bone: cortical thickness1.62.75.21.11.31.02.31.9-1.7-1.7-0.31.62.1-2.1-1.7
Bone: cortical thickness0.91.13.30.40.30.11.11.2-0.9-0.5-0.10.91.5-1.5-1.8
Bone: cortical tissue density0.60.82.1-1.3-1.2-1.4-0.5-0.10.60.4-1.1-0.30.6-0.8-0.9
Condit. Reinf. active minus inactive responses0.20.20.8-0.3-0.4-0.4-0.6-0.50.90.4-0.7-0.7-0.0-0.00.1
Condit. Reinf. active-inactive response ratio0.40.41.0-0.0-0.10.1-0.7-0.61.00.4-0.3-0.7-0.90.90.8
Condit. Reinf. active responses0.40.51.6-0.5-0.6-1.00.10.20.3-0.3-1.1-0.01.1-1.3-0.9
Condit. Reinf. inactive responses1.31.65.2-0.5-0.6-1.10.80.9-0.8-1.0-1.01.02.1-2.3-1.7
Incentive salience index mean0.10.20.40.60.60.60.2-0.30.70.30.0-0.60.1-0.20.0
Condit. Reinf. lever presses0.40.61.91.11.41.21.10.2-0.0-0.10.5-0.10.7-0.8-0.3
Condit. Reinf. active minus inactive responses1.62.14.7-0.20.1-0.51.41.3-1.7-2.1-1.12.21.9-1.9-1.2
Condit. Reinf. active-inactive response ratio3.03.58.5-1.3-0.8-1.41.11.4-1.5-1.6-2.22.22.8-2.9-1.8
Condit. Reinf. active responses0.71.02.8-0.30.3-0.21.20.5-1.4-1.7-0.31.61.2-1.2-0.3
Condit. Reinf. inactive responses0.91.22.90.81.21.20.2-1.0-0.10.01.7-0.4-1.41.41.7
Condit. Reinf. lever presses1.11.53.70.81.20.81.61.0-1.6-1.90.01.61.2-1.2-0.7
Condit. Reinf. lever reinforcers received0.60.92.3-0.5-0.0-0.50.90.4-1.2-1.5-0.61.41.2-1.2-0.5
Conditioned reinforcement - actives0.40.61.4-0.5-0.6-0.3-1.2-1.10.80.6-0.4-0.7-1.01.00.5
Conditioned reinforcement - inactives0.50.72.3-1.3-1.1-1.2-0.8-0.60.5-0.3-1.5-0.10.2-0.3-0.4
Conditioned locomotion1.21.63.2-0.7-0.9-0.6-1.7-1.81.71.1-0.1-1.6-1.51.50.6
Patch foraging indifference point 0 sec0.81.53.11.30.90.41.11.6-1.7-1.4-0.91.81.0-0.9-1.0
Patch foraging indifference point AUC1.01.43.90.70.40.61.32.0-1.3-1.5-0.51.31.4-1.2-1.1
Delay disc. indifference point, 0s delay0.30.41.00.50.41.00.20.4-1.00.1-0.61.00.4-0.40.2
Delay disc. indifference point, 16s delay0.80.92.5-1.2-1.6-1.3-0.60.20.71.0-0.2-0.70.6-0.7-1.4
Delay disc. indifference point, 2s delay2.62.95.61.72.32.02.11.1-2.4-1.90.12.31.0-0.80.8
Delay disc. indifference point, 24s delay0.50.61.7-0.8-1.2-0.7-0.90.20.60.5-0.9-0.40.2-0.3-1.3
Delay disc. indifference point, 4s delay0.30.30.8-0.3-0.20.30.20.2-0.60.4-0.70.70.8-0.9-0.4
Delay disc. indifference point, 8s delay0.10.10.40.00.40.60.2-0.4-0.20.10.10.20.0-0.10.1
Indifference point function ln k0.50.82.31.31.51.31.00.4-1.00.20.40.90.6-0.60.2
Indifference point function log k0.50.82.31.31.51.31.00.4-1.00.20.40.90.6-0.60.2
Patch foraging total patch changes 0 sec1.12.04.21.10.70.21.12.0-1.9-1.5-1.32.11.5-1.3-1.3
Patch foraging total patch changes 12 sec0.30.41.9-0.2-0.5-0.8-0.10.6-0.2-0.8-1.40.40.5-0.5-0.7
Patch foraging total patch changes 18 sec0.40.71.7-0.6-0.9-1.0-0.10.9-0.4-0.8-1.30.60.9-0.8-0.8
Patch foraging total patch changes 24 sec0.81.32.5-0.2-0.5-0.90.41.5-1.0-1.4-1.61.31.4-1.3-1.1
Patch foraging total patch changes 6 sec1.92.95.90.0-0.3-0.61.02.3-1.8-2.4-2.02.11.9-1.7-2.3
Patch foraging time to switch 0 sec2.45.010.1-1.9-1.8-1.7-2.5-2.83.22.70.6-3.0-2.11.81.2
Patch foraging water rate 0 sec0.71.52.61.00.80.61.01.5-1.3-1.3-1.01.51.3-1.2-1.6
Patch foraging water rate 12 sec0.61.42.80.70.60.51.21.3-1.5-0.4-0.51.51.7-1.7-1.1
Patch foraging water rate 18 sec0.60.91.91.40.91.31.11.4-0.8-0.30.80.60.8-0.7-1.1
Patch foraging water rate 24 sec0.70.92.20.50.60.61.01.2-1.0-0.4-0.11.11.5-1.5-0.9
Patch foraging water rate 6 sec1.42.03.8-0.3-0.5-0.50.71.6-1.5-1.3-1.81.81.9-1.9-1.4
Seeking ratio, delayed vs. immediate footshock0.91.12.8-0.00.0-0.1-0.5-1.21.41.21.6-1.7-1.21.10.2
Distance traveled before self-admin0.30.30.8-0.7-0.3-0.2-0.3-0.90.80.10.4-0.8-0.70.70.5
Distance traveled after self-admin0.50.62.1-1.2-0.2-0.5-0.4-1.40.7-0.5-0.3-0.6-0.80.80.5
Extensor digitorum longus weight2.49.631.15.05.35.63.41.7-1.7-2.02.81.0-0.10.40.4
Bone: elastic displacement0.50.51.6-0.3-0.4-0.3-0.6-0.50.8-0.50.2-1.1-1.21.30.4
Bone: elastic work0.30.42.60.30.60.30.90.3-0.3-1.60.00.20.1-0.1-0.6
Bone: endosteal estimation0.71.64.32.12.11.61.41.0-1.0-1.20.70.90.4-0.3-0.6
Bone: endosteal perimeter0.40.93.31.81.81.60.70.2-0.10.11.1-0.2-0.40.4-0.2
Epididymis fat weight0.41.53.01.61.41.41.41.7-1.4-0.50.21.11.2-1.2-0.5
Delta time in closed arm before/after self-admin1.91.84.5-0.20.10.0-1.1-2.11.41.70.8-1.6-1.61.41.7
Delta time in open arm before/after self-admin4.44.49.71.21.31.02.42.7-2.5-3.1-0.82.62.2-2.0-1.9
Diff in mean of infusions in LGA sessions0.91.12.7-0.5-0.4-0.70.71.3-0.6-1.2-0.90.81.4-1.4-1.7
Delay discount exponential model param0.10.10.30.30.2-0.2-0.0-0.20.2-0.40.4-0.3-0.50.50.6
Extinction: sum of active levers before priming0.40.40.9-0.9-0.8-0.9-0.7-0.30.9-0.4-0.9-0.7-0.30.3-0.4
Active lever presses in extinction session 60.90.91.61.21.31.11.31.0-0.9-1.30.60.80.3-0.2-0.3
Bone: final force3.96.212.42.73.22.53.52.2-3.0-2.90.72.81.9-1.7-1.2
Bone: final moment3.55.711.22.52.92.23.32.2-2.8-3.00.52.71.9-1.7-1.4
Food consumed during 24 hour testing period1.21.73.91.01.31.11.61.0-1.9-1.5-0.32.01.2-1.1-0.2
Glucose0.30.51.30.50.20.50.21.1-1.0-0.8-0.91.10.4-0.2-0.0
Heart weight0.30.52.01.00.30.50.31.4-0.9-0.1-0.20.80.7-0.6-0.7
Delay discount hyperbolic model param0.20.20.40.0-0.2-0.4-0.4-0.30.50.00.4-0.6-0.60.60.5
Intermittent access intake day 1-15 change0.71.44.4-1.5-1.7-1.6-1.10.10.20.6-2.10.40.8-0.9-1.0
Intermittent access intake escalation0.61.33.9-1.4-1.6-1.5-0.90.20.10.5-2.00.40.9-1.0-1.3
Intermittent access intake escalation 21.01.22.7-1.4-1.6-1.5-1.00.10.50.8-1.6-0.10.7-0.8-1.2
Intermitt. access day 1 inactive lever presses0.31.23.9-1.4-1.3-1.5-0.30.2-0.3-0.3-2.00.81.2-1.3-0.8
Intermitt. access day 15 inactive lever presses0.10.30.80.70.90.60.5-0.1-0.6-0.20.00.60.3-0.30.4
Intermitt. access escalation Index0.20.20.60.10.0-0.10.60.7-0.3-0.80.00.30.6-0.6-0.6
Intermittent access day 1 total infusions0.30.52.1-0.1-0.1-0.30.20.6-0.1-1.4-1.00.20.6-0.5-1.3
Intermittent access day 15 total infusions1.11.75.5-1.4-1.5-1.6-0.70.50.1-0.4-2.30.51.2-1.3-1.8
Intermittent access terminal intake (last 3 days)1.01.34.2-1.0-1.0-1.2-0.30.7-0.1-1.0-2.00.51.1-1.1-1.9
Intermittent access total infusions0.50.62.70.10.2-0.10.50.7-0.2-1.5-0.80.40.7-0.7-1.6
Intermittent access day 1 locomotion0.40.62.8-0.3-0.3-0.50.20.60.0-0.9-0.80.10.9-0.9-1.7
Intermittent access day 15 total locomotion1.01.96.3-1.0-1.1-1.40.01.1-0.2-1.0-1.80.51.7-1.8-2.5
Intermittent access total locomotion1.01.24.30.20.2-0.10.91.3-0.6-1.6-0.80.71.4-1.4-2.1
Intermittent access standard deviation0.51.13.2-0.3-0.4-0.4-0.01.1-0.7-0.3-1.81.11.3-1.3-1.7
Left kidney weight2.09.529.25.44.65.13.12.6-2.5-0.93.41.40.10.30.9
Right kidney weight1.98.725.05.04.24.53.23.0-2.9-1.32.72.10.6-0.20.7
Cocaine induced anxiety0.20.30.8-0.9-0.9-0.9-0.6-0.40.40.6-0.4-0.20.1-0.20.3
Post-drug Anxiety0.10.10.30.1-0.2-0.10.20.5-0.10.00.50.10.1-0.00.2
Baseline Anxiety0.80.92.31.51.31.51.11.1-0.7-0.91.10.40.00.1-0.5
Tail length0.51.96.62.61.91.81.21.5-1.3-1.30.71.10.2-0.0-0.5
Length with tail0.62.87.52.62.12.30.7-0.10.2-0.12.7-0.8-1.82.00.7
Length without tail0.72.48.31.50.81.3-0.3-0.51.01.02.9-1.6-2.12.31.1
Times rat made contact with spout0.20.20.4-0.40.40.30.4-0.6-0.4-0.6-0.50.60.5-0.6-0.5
Lifetime Intake0.30.31.80.20.30.10.40.5-0.3-1.3-0.60.40.4-0.3-0.9
Liver weight, left0.40.62.60.4-0.70.1-0.71.6-0.3-0.1-1.20.50.3-0.1-1.2
Liver weight, right0.20.41.10.5-0.20.3-1.10.30.50.8-0.1-0.5-0.80.90.2
Locomotor activity0.30.41.80.60.50.5-0.1-0.3-0.3-0.60.40.2-1.11.30.8
Locomotor testing distance0.10.20.80.1-0.1-0.1-0.20.6-0.4-0.5-0.90.50.2-0.1-0.7
Locomotor testing rearing0.71.43.6-1.5-1.9-1.9-1.5-0.10.70.4-1.4-0.50.0-0.0-1.2
Locomotion in novel chamber1.72.16.30.40.10.41.22.1-1.1-1.4-0.61.22.0-1.9-2.5
Locomotion in novel chamber post-restriction1.42.45.1-2.2-2.1-2.3-0.50.50.1-0.5-2.10.31.6-1.7-1.9
Fecal boli incidents, locomotor time 11.11.63.9-1.0-1.3-0.8-2.0-1.01.21.9-0.2-1.1-1.41.40.5
Change in fecal boli incidents, locomotor task1.81.84.71.31.41.62.21.5-0.9-1.61.50.61.0-0.9-0.7
Time >=10cm from walls, locomotor time 10.90.94.0-0.70.1-0.5-0.5-1.90.30.30.0-0.3-1.21.12.0
Bouts of movement, locomotor time 10.30.31.4-0.4-0.7-0.3-0.9-0.10.51.2-0.2-0.5-0.30.3-0.0
Total resting periods, locomotor time 10.30.31.4-0.4-0.6-0.2-0.8-0.20.61.2-0.1-0.6-0.30.3-0.1
Rest time, locomotor task time 10.60.81.8-0.3-0.4-0.1-0.9-0.81.21.11.0-1.4-1.11.0-0.1
Distance moved, locomotor task time 11.62.55.00.10.4-0.11.41.6-1.7-1.8-1.72.02.2-2.2-1.5
Vertical activity count, locomotor time 10.71.63.90.20.5-0.21.21.0-1.7-1.8-1.52.01.5-1.5-0.3
Time >=10cm from walls, locomotor time 20.50.73.20.40.80.3-0.0-1.20.10.30.6-0.2-1.21.21.8
Bouts of movement, locomotor time 20.30.41.1-0.8-0.3-1.0-0.3-1.00.70.3-0.7-0.60.2-0.5-0.7
Total resting periods, locomotor time 20.10.20.9-0.4-0.1-0.7-0.3-0.90.70.5-0.3-0.60.1-0.3-0.4
Rest time, locomotor task time 20.40.51.40.80.41.0-0.10.2-0.10.81.2-0.2-0.70.80.7
Distance moved, locomotor task time 21.11.44.2-1.3-0.6-1.40.3-0.0-0.5-1.0-2.00.91.5-1.6-1.0
Vertical activity count, locomotor time 20.81.13.3-1.4-0.8-1.7-0.0-0.2-0.7-1.0-1.81.10.7-0.80.1
Light reinforcement 10.51.33.2-0.7-0.7-0.8-1.1-1.20.80.61.0-1.0-1.71.81.4
Light reinforcement 20.10.10.60.50.40.10.20.30.2-0.30.8-0.2-0.30.3-0.2
Bone: marrow area0.71.54.22.02.01.61.41.0-1.0-1.30.70.90.4-0.3-0.5
Bone: maximum diameter1.63.06.12.52.42.12.31.7-1.8-1.60.91.51.1-1.0-1.0
Bone: maximum force3.15.610.82.73.22.43.32.0-2.7-2.90.72.61.6-1.4-1.1
Bone: maximum moment2.84.99.42.52.92.13.12.0-2.5-2.90.62.51.5-1.4-1.2
Mean time between licks in bursts0.51.32.9-1.7-1.5-1.1-1.5-0.90.9-0.2-1.5-0.5-1.01.00.9
Mean num. licks in bursts2.03.28.12.52.82.81.4-0.1-0.8-1.52.10.3-1.41.61.4
Cd content in liver0.50.62.1-1.3-1.0-1.0-0.3-0.40.1-0.5-1.50.20.4-0.5-0.3
Co content in liver2.02.34.51.71.71.32.11.3-1.9-1.90.81.80.9-0.8-1.3
Cu content in liver1.51.85.01.31.81.42.20.8-1.1-1.40.81.01.2-1.2-0.8
Fe content in liver1.11.33.2-0.7-1.1-0.90.11.2-0.6-0.8-1.61.01.4-1.3-1.8
K content in liver2.62.55.82.12.42.12.40.9-0.7-1.52.30.40.5-0.5-0.2
Mg content in liver1.31.34.31.91.71.60.9-0.00.3-0.12.1-0.6-0.80.90.3
Mn content in liver0.30.41.20.80.81.10.40.8-0.5-0.50.10.30.3-0.2-0.9
Na content in liver2.93.18.32.82.92.91.80.3-0.7-0.42.40.2-0.60.81.3
Rb content in liver1.61.93.9-0.4-0.5-0.50.91.5-1.2-1.9-1.41.51.8-1.7-2.0
Se content in liver0.30.42.2-0.2-0.0-0.10.40.5-0.3-0.4-0.20.50.8-0.8-1.5
Sr content in liver0.40.30.60.30.30.70.40.7-0.8-0.1-0.50.70.6-0.6-0.7
Zn content in liver0.70.82.61.31.61.41.2-0.2-0.7-0.10.70.60.3-0.30.5
Bone: minimum diameter0.91.74.21.92.11.51.71.1-1.2-1.20.21.10.8-0.8-1.0
Time in familiar zone, hab. session 12.22.15.2-0.7-0.8-1.20.71.8-1.0-0.2-1.41.52.2-2.3-1.8
Time in novel zone, hab. session 14.54.511.10.91.01.6-1.2-2.71.40.92.1-1.9-3.33.32.8
Total zone transitions, hab. session 11.21.72.91.41.41.51.71.6-1.7-1.50.91.30.8-0.6-0.4
Total locomotion distance, hab. session 11.82.54.52.12.12.11.81.1-2.1-1.31.41.40.20.01.6
Locomotion velocity, hab. session 11.52.14.41.71.71.71.71.2-2.1-1.41.11.40.3-0.11.5
Time in familiar zone, hab. session 22.02.14.90.10.3-0.11.31.6-1.3-1.2-1.41.82.2-2.2-1.8
Time in novel zone, hab. session 21.31.32.8-0.3-0.5-0.1-1.3-1.30.81.00.7-1.2-1.61.71.7
Total zone transitions, hab. session 20.60.81.91.21.21.30.90.8-0.7-1.41.00.3-0.20.4-0.4
Total locomotion distance, hab. session 20.60.81.71.21.31.21.00.5-0.9-0.80.80.4-0.20.31.0
Locomotion velocity, hab. session 20.91.22.81.51.71.51.30.5-1.2-1.01.10.6-0.20.41.2
Novel to familiar place preference ratio0.90.93.0-1.6-1.3-1.7-1.1-0.90.3-0.3-1.0-0.0-0.50.50.7
Novelty place preference0.80.93.2-1.7-1.4-1.8-0.9-0.70.2-0.4-1.10.2-0.30.20.4
Time in novel zone, NPP test1.11.13.8-1.8-1.5-1.9-1.0-0.70.1-0.4-1.40.2-0.10.10.4
Total zone transitions, NPP test0.91.33.31.71.71.81.41.0-0.6-0.91.50.10.3-0.2-0.4
Total locomotion distance, NPP test0.50.72.01.31.21.40.70.6-0.50.01.00.00.00.11.1
Locomotion velocity, NPP test0.81.13.01.71.51.70.90.7-0.40.01.6-0.2-0.20.31.1
Intraocular pressure0.60.81.6-1.3-1.1-0.8-0.8-0.91.2-0.3-0.4-1.1-0.70.7-1.0
Delta distance traveled before/after self-admin0.10.10.5-0.6-0.1-0.6-0.1-0.70.1-0.2-0.4-0.1-0.10.00.2
Delta ambulatory time before/after self-admin0.20.20.5-0.7-0.1-0.7-0.0-0.7-0.1-0.5-0.70.20.1-0.10.2
Parametrial fat weight4.09.419.53.22.82.63.84.4-3.6-2.90.73.23.2-3.0-1.5
Pavlov. Cond. lever latency0.60.82.6-1.4-1.5-1.6-0.60.1-0.2-0.2-1.10.30.4-0.4-0.4
Pavlov. Cond. magazine entry latency1.21.53.71.91.41.8-0.2-0.6-0.10.81.0-0.3-1.31.41.9
Pavlov. Cond. change in total contacts1.61.72.51.11.21.5-0.2-1.41.21.01.6-1.5-1.51.51.2
Pavlov. Cond. index score0.60.82.31.41.21.50.1-0.40.20.70.8-0.4-0.70.71.0
Pavlov. Cond. latency score0.70.93.21.71.51.80.4-0.00.00.41.0-0.3-0.50.60.7
Pavlov. Cond. lever contacts1.01.13.61.71.81.90.6-0.30.30.21.3-0.5-0.70.70.8
Pavlov. Cond. magazine entry number0.81.02.4-1.0-0.7-1.20.80.9-0.5-1.0-0.30.61.2-1.3-1.5
Pavlov. Cond. intertrial magazine entries1.01.23.7-0.9-1.0-1.50.21.00.1-0.9-1.20.31.3-1.4-1.9
Pavlov. Cond. lever-magazine prob. diff.0.60.72.21.31.21.50.1-0.40.10.60.7-0.3-0.60.71.1
Pavlov. Cond. response bias1.01.22.51.10.91.3-0.6-1.10.71.10.7-1.0-1.41.41.6
Pavlov. Cond. lever latency0.91.22.0-0.9-1.0-1.0-1.3-1.01.41.4-0.2-1.2-1.11.10.8
Pavlov. Cond. magazine entry latency1.11.33.4-1.1-1.5-1.1-1.8-1.01.21.3-0.7-1.1-0.80.80.3
Pavlov. Cond. change in total contacts0.50.81.90.0-0.2-0.30.41.0-1.1-1.4-0.61.11.0-0.9-1.3
Pavlov. Cond. index score0.10.20.4-0.2-0.5-0.3-0.20.3-0.5-0.3-0.60.50.5-0.6-0.6
Pavlov. Cond. latency score0.10.10.30.1-0.3-0.0-0.20.4-0.4-0.1-0.40.30.4-0.4-0.5
Pavlov. Cond. lever contacts0.91.32.21.11.01.11.31.1-1.5-1.50.51.31.0-0.9-0.7
Pavlov. Cond. magazine entry number0.91.13.21.61.81.61.30.8-0.8-0.80.90.70.00.10.4
Pavlov. Cond. intertrial magazine entries1.72.66.52.42.52.61.70.9-1.5-1.41.21.30.00.11.0
Pavlov. Cond. lever-magazine prob. diff.0.10.20.5-0.3-0.6-0.4-0.50.0-0.1-0.1-0.70.20.2-0.3-0.5
Pavlov. Cond. response bias0.30.30.9-0.4-0.4-0.30.20.2-0.6-0.7-0.40.60.9-0.9-0.6
Time in closed arm before self-admin0.70.92.3-1.1-1.5-1.1-1.20.10.21.2-1.50.20.4-0.5-0.3
Time in closed arm after self-admin2.83.09.0-1.6-2.0-1.7-2.2-1.62.13.00.1-2.1-1.00.80.5
Time in open arm before self-admin0.91.03.60.80.70.80.2-0.61.10.01.9-1.4-1.21.30.2
Time in open arm after self-admin3.94.311.81.82.42.12.71.9-2.3-3.4-0.22.31.4-1.2-1.3
Bone: periosteal estimation2.34.89.73.03.12.52.92.1-1.9-2.10.91.71.6-1.5-1.8
Bone: periosteal perimeter0.91.64.92.22.12.01.30.8-0.8-0.61.40.40.10.1-0.4
Bone: post-yield work2.73.99.03.03.02.82.41.6-2.0-1.41.61.80.7-0.60.5
Progressive ratio test 1 active lever presses0.20.21.6-0.1-0.1-0.50.10.3-0.1-1.3-0.60.20.2-0.1-0.4
Progressive ratio test 1 breakpoint0.20.21.6-0.2-0.3-0.60.10.3-0.1-1.2-0.70.30.2-0.2-0.4
Progressive ratio test 1 inactive lever presses0.00.10.2-0.00.2-0.00.0-0.3-0.1-0.4-0.50.2-0.10.10.4
Progressive ratio test 2 active lever presses0.91.02.0-1.2-1.4-1.4-1.3-0.61.30.2-1.1-1.0-0.30.3-1.0
Progressive ratio test 2 breakpoint0.80.91.6-1.0-1.2-1.3-1.2-0.51.20.1-1.0-0.9-0.30.3-1.0
Progressive ratio test 2 inactive lever presses0.30.51.40.20.00.1-0.7-0.91.20.50.3-1.2-1.01.0-0.0
Incentive Sensitization - Responses0.60.92.0-0.7-0.8-0.6-1.3-1.11.40.8-0.6-1.2-1.00.9-0.4
Incentive Sensitization - Breakpoint0.50.61.5-0.5-0.5-0.3-1.1-0.91.20.6-0.5-1.0-0.90.9-0.4
Sum of active levers in priming session hrs 5-61.41.33.71.51.61.50.7-0.20.5-0.31.9-0.9-1.21.30.4
Progressive ratio0.30.51.20.70.30.9-0.40.10.10.80.8-0.3-1.01.10.7
Food seeking constrained by brief footshock0.10.10.20.1-0.20.0-0.20.5-0.2-0.4-0.50.30.00.1-0.5
Seeking ratio, punishment vs. effort0.10.10.70.10.50.10.5-0.2-0.3-0.90.10.20.2-0.20.1
Retroperitoneal fat weight0.73.212.52.61.21.81.53.5-2.2-1.10.91.81.2-0.80.2
Reaction time number correct0.61.22.2-1.5-1.4-1.2-1.5-1.31.20.8-0.6-1.1-0.90.80.3
Reaction time mean minus median0.00.10.20.40.30.40.20.2-0.4-0.1-0.40.40.1-0.00.2
Reaction time mean minus median AUC0.00.00.2-0.3-0.3-0.2-0.1-0.10.0-0.2-0.50.1-0.10.1-0.0
Reaction time num false alarms0.10.20.9-1.0-0.6-0.6-0.10.1-0.0-0.2-0.40.10.4-0.5-0.5
Reaction time num false alarms AUC0.00.00.3-0.3-0.00.20.20.10.00.10.6-0.10.1-0.1-0.1
Reaction time trials correct on left0.61.22.2-1.5-1.4-1.2-1.5-1.31.20.8-0.6-1.1-0.90.80.3
Reaction time trials on left0.61.22.2-1.4-1.4-1.2-1.5-1.31.20.8-0.6-1.1-1.00.90.3
Reaction time mean0.40.62.20.70.60.8-0.1-0.3-0.00.20.7-0.2-1.21.31.5
Reaction time mean AUC0.50.82.40.60.50.7-0.3-0.60.50.40.9-0.7-1.41.61.5
Median of all reaction times0.60.82.70.70.60.8-0.2-0.50.10.21.0-0.4-1.41.61.6
Reaction time omissions0.91.22.80.50.61.2-0.6-1.10.81.01.4-1.0-1.61.71.2
Reaction time false alarm rate0.20.20.40.10.40.40.60.6-0.4-0.30.40.40.6-0.6-0.5
Reaction time premature initiation rate2.02.75.90.30.81.3-0.8-2.20.81.61.7-1.3-2.42.42.3
Reaction time premature initiations2.44.39.3-0.40.10.7-1.6-3.01.72.21.6-2.1-3.03.02.6
Std. dev. reaction times0.10.20.40.60.30.6-0.10.20.00.40.1-0.1-0.40.50.6
Reaction time trials completed0.61.22.2-1.4-1.4-1.2-1.5-1.31.20.8-0.6-1.1-1.00.90.3
Reaction time trials AUC0.51.01.9-1.3-1.2-1.1-1.4-1.21.10.7-0.5-1.0-0.90.80.3
Run reversals in cocaine runway, females1.61.65.42.02.02.30.9-0.2-0.4-0.11.6-0.1-0.80.90.9
Run reversals in cocaine runway, males0.20.20.90.00.50.30.2-0.90.50.20.8-0.6-0.50.40.2
Latency to leave start box in cocaine runway1.61.84.20.60.50.41.82.0-1.5-1.10.11.41.9-1.9-1.2
Latency to leave start box in cocaine runway, F0.50.61.7-0.5-0.7-0.70.20.70.00.4-0.70.11.2-1.3-1.0
Latency to leave start box in cocaine runway, M2.52.44.91.41.41.32.22.0-2.0-1.71.11.71.3-1.1-0.3
Std. dev. time between licks in bursts0.20.31.7-0.4-0.5-0.3-0.20.4-0.1-0.8-1.30.50.3-0.2-0.3
Total sessions with >9 infusions0.30.41.80.70.90.60.40.1-0.6-1.3-0.30.6-0.10.20.2
Short access day 1 total inactive lever presses1.41.83.90.90.91.2-0.6-1.61.21.01.5-1.4-2.02.01.3
Short access day 10 total inactive lever presses0.20.51.4-1.1-0.7-0.8-0.7-1.20.60.9-0.5-0.4-0.30.20.6
Short access day 1 total infusions1.62.14.6-0.6-0.5-0.3-1.5-2.11.60.60.2-1.6-2.12.11.7
Short access day 10 total infusions0.10.21.1-0.3-0.2-0.5-0.4-0.30.0-0.4-1.10.10.0-0.0-0.1
Short access total infusions0.10.20.60.30.50.3-0.0-0.4-0.1-0.8-0.20.0-0.50.60.6
Short access day 1 locomotion0.91.13.4-1.1-0.6-1.0-1.0-1.81.40.4-0.2-1.3-1.00.90.5
Short access day 10 total locomotion0.50.92.1-0.30.2-0.30.70.6-1.1-0.9-1.31.51.3-1.4-0.6
Short access total locomotion0.80.92.40.40.50.21.01.1-1.1-1.6-0.71.21.1-1.0-0.9
One hour access (0.3 mA shock)0.81.03.3-0.4-0.8-0.9-0.31.2-0.6-0.9-1.81.01.0-0.9-1.1
Compulsive drug intake0.50.61.41.21.20.90.90.4-0.7-0.51.20.4-0.20.31.0
One hour access (shock baseline)0.71.13.4-0.9-1.1-1.1-0.30.9-0.3-0.8-1.80.71.1-1.1-1.6
Social response proportion0.50.61.7-0.8-1.0-0.8-1.3-0.60.50.8-0.9-0.3-0.60.60.5
Social responses0.40.51.3-0.5-0.9-0.7-1.2-0.20.71.0-0.8-0.6-0.40.5-0.2
Social time0.50.72.1-1.2-1.5-1.4-1.10.10.50.3-1.2-0.1-0.20.3-0.3
Soleus weight2.16.312.93.63.12.93.03.1-2.7-2.40.82.11.8-1.6-1.2
Bone: stiffness4.67.413.73.13.32.73.72.7-3.2-2.81.03.02.2-2.1-1.7
Tibialis anterior weight4.214.433.65.45.85.84.73.0-3.8-3.62.33.21.1-0.60.2
Time to tail flick, vehicle, before self-admin0.60.61.61.30.91.20.81.0-0.5-0.80.60.40.2-0.1-0.7
Time to tail flick, vehicle, after self-admin0.10.10.40.3-0.3-0.4-0.20.50.40.40.4-0.4-0.00.1-0.7
Time to tail flick, test, before self-admin0.90.93.01.71.61.70.60.3-0.8-0.20.40.6-0.30.40.6
Time to tail flick, test, after self-admin0.90.92.7-0.8-1.0-0.9-0.60.5-0.31.0-1.60.61.2-1.4-0.5
Delta time to tail flick, vehicle, before/after SA0.10.10.2-0.0-0.1-0.40.30.3-0.2-0.00.00.10.4-0.5-0.2
Delta time to tail flick, test, before/after SA0.70.71.5-0.9-1.0-0.9-0.30.6-0.60.3-1.20.81.1-1.2-0.4
Tibia length0.10.20.40.50.30.20.50.6-0.6-0.6-0.30.60.4-0.4-0.4
Ambulatory time before self-admin0.30.51.4-1.2-0.8-0.9-0.4-0.71.00.2-0.0-1.0-0.30.2-0.3
Ambulatory time after self-admin0.81.02.9-1.6-0.7-1.0-0.7-1.71.2-0.1-0.4-1.1-0.90.80.1
Bone: tissue strength0.50.51.40.50.90.90.6-0.50.2-0.51.2-0.4-0.80.81.1
Total heroin consumption0.30.41.60.40.20.40.00.60.5-1.3-0.3-0.5-0.40.5-1.1
Bone: trabecular number0.40.61.20.40.60.31.00.9-0.9-1.1-0.30.90.8-0.7-0.8
Bone: trabecular spacing1.31.73.5-0.0-0.20.1-1.2-1.41.51.50.8-1.6-1.91.81.6
Bone: trabecular thickness1.92.44.21.00.70.51.32.1-2.0-2.0-0.82.11.8-1.7-1.5
Bone: trabecular tissue density0.50.72.61.61.11.10.80.80.1-0.01.2-0.3-0.30.4-0.3
Water consumed over 24 hours0.71.02.6-1.0-0.7-0.6-1.1-1.61.31.4-0.1-1.2-0.60.4-0.5
Number of responses in last shaping day0.70.82.4-0.1-0.10.1-0.8-1.10.90.20.3-0.9-1.51.61.3