Hub : Genes

Tnrc6a

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Brain gene expression Tnrc6a 0.18 0.08 3.5e-13 0.12 0.12 0.12 0.12 7.5e-11 2.2e-11 6.3e-11 1.5e-11
2 BLA gene expression Tnrc6a 0.07 0.05 6.5e-03 0.02 0.02 0.03 0.03 3.4e-02 2.4e-02 1.1e-02 1.2e-02
3 PL gene expression Tnrc6a 0.08 0.04 7.8e-11 0.07 0.09 0.08 0.08 5.7e-08 3.4e-10 1.7e-09 2.1e-09
4 NAcc gene expression Tnrc6a 0.03 0.01 1.4e-03 0.01 0.02 0.02 0.02 6.0e-03 3.4e-03 2.3e-03 5.6e-03
5 IL gene expression Tnrc6a 0.19 0.11 8.5e-03 0.13 0.03 0.08 0.09 5.8e-04 6.7e-02 5.9e-03 3.3e-03
6 PL intron excision ratio chr1_177701195_177701980 0.04 0.02 1.2e-03 0.02 0.02 0.02 0.02 1.7e-03 2.5e-03 2.0e-03 5.6e-03
7 Adipose mRNA stability Tnrc6a 0.22 0.11 2.6e-11 0.06 0.09 0.07 0.08 8.2e-07 1.0e-09 1.4e-08 3.4e-09
8 Brain isoform ratio NM_001395157.1 0.06 0.04 6.9e-04 0.04 0.04 0.05 0.04 6.9e-05 2.7e-04 3.7e-05 6.8e-05
9 PL intron excision ratio chr1_177701195_177701675 0.03 0.02 4.5e-03 0 0.01 0 0 2.4e-01 4.2e-02 2.9e-01 2.9e-01
10 Brain alternative polyA XM_017589209.2 0.08 0.06 1.2e-03 0.03 0.03 0.02 0.03 6.5e-04 6.0e-04 5.0e-03 1.5e-03
11 Brain alternative polyA XM_017589208.2 0.09 0.06 1.1e-03 0.04 0.04 0.04 0.04 2.4e-04 1.4e-04 1.4e-04 2.9e-04
12 Adipose gene expression Tnrc6a 0.04 0.03 8.7e-03 -0 0 -0 0 3.7e-01 1.1e-01 4.2e-01 2.6e-01
13 Liver alternative TSS NM_001395157.1 0.04 0.03 7.0e-03 0 0.01 0.02 0 8.2e-02 2.4e-02 4.0e-03 1.4e-01
14 Liver alternative TSS NM_001395157.1 0.05 0.04 5.6e-03 0 0.01 0.02 0 9.4e-02 1.5e-02 4.2e-03 7.9e-02
15 Brain mRNA stability Tnrc6a 0.26 0.1 1.0e-12 0.13 0.14 0.14 0.16 9.3e-12 1.1e-12 2.3e-13 1.8e-14

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15
Bone: apparent density0.20.40.90.9-0.70.8-0.6-0.5-0.41.00.5-0.4-0.10.2-0.70.80.80.4
Area under the delay curve0.20.30.6-0.0-0.3-0.10.10.1-0.70.30.7-0.80.7-0.7-0.50.50.50.4
BMI with tail1.65.19.32.6-3.12.1-1.9-2.7-2.82.32.7-1.81.0-1.2-1.42.32.32.4
BMI without tail3.87.815.63.6-3.93.1-3.1-3.4-3.62.83.2-1.60.5-0.7-1.42.82.82.4
Body weight1.35.615.53.9-3.73.5-3.4-3.4-2.02.31.30.3-1.41.3-0.11.21.21.0
Weight adjusted by age0.91.02.80.8-0.70.3-0.0-0.7-1.70.51.7-1.11.2-1.2-0.51.31.20.7
Bone surface0.61.13.01.6-1.11.7-1.3-1.1-1.21.50.8-0.3-0.10.1-1.10.40.40.1
Bone volume0.81.43.21.8-1.41.7-1.4-1.2-1.51.61.2-0.6-0.0-0.0-1.11.00.90.4
Breakpoint value in progressive ratio session0.10.20.6-0.30.1-0.30.00.10.20.30.2-0.60.1-0.0-0.50.80.80.5
Number of licking bursts4.25.012.3-3.12.9-3.13.52.10.1-1.50.4-2.03.4-3.3-0.9-0.00.00.5
Context. condit. distance diff. score0.50.71.8-0.80.6-1.10.80.9-0.7-0.80.6-0.81.3-1.30.20.50.50.3
Locomotion velocity, session 10.20.20.90.30.00.4-0.4-0.1-0.50.30.6-0.30.2-0.2-0.41.01.00.2
Locomotion distance, session 10.20.20.80.4-0.30.2-0.4-0.3-0.40.20.6-0.40.3-0.2-0.10.90.90.5
Locomotion velocity, session 20.40.41.20.5-0.20.3-0.10.1-1.10.50.9-0.80.8-0.8-0.60.90.90.1
Locomotion distance, session 20.30.41.00.8-0.90.8-0.7-1.0-0.50.70.6-0.40.3-0.3-0.60.60.60.7
Locomotion velocity, session 30.91.13.01.5-1.71.6-1.7-1.3-0.91.20.30.1-0.60.5-0.3-0.3-0.40.1
Locomotion distance, session 30.20.30.60.3-0.50.7-0.80.2-0.50.4-0.20.2-0.30.2-0.4-0.8-0.8-0.5
Stereotopy head waving bouts, day 30.20.31.1-0.10.10.20.0-0.41.00.5-0.40.3-0.80.7-0.50.50.50.8
Stereotopy head waving duration, day 30.20.20.60.2-0.30.5-0.3-0.60.60.8-0.20.1-0.60.5-0.60.20.20.5
Locomotion velocity, session 71.01.13.00.8-0.50.9-1.40.20.4-0.9-0.91.7-1.41.41.7-0.5-0.5-1.3
Locomotion distance, session 70.30.41.3-0.71.1-0.60.70.8-0.1-0.9-0.1-0.11.0-1.00.3-0.0-0.0-0.4
Stereotopy head waving bouts, day 70.50.61.60.6-1.00.9-1.2-0.60.60.3-0.50.8-1.31.20.4-0.4-0.40.0
Stereotopy head waving duration, day 70.60.72.31.1-1.41.3-1.5-0.8-0.10.70.00.5-1.00.90.10.00.00.2
Locomotion velocity, session 80.10.10.50.5-0.70.4-0.7-0.1-0.40.30.2-0.1-0.30.3-0.10.00.00.2
Locomotion distance, session 80.30.41.6-0.10.0-0.20.20.0-0.8-0.00.8-0.91.3-1.3-0.40.50.60.5
Degree of sensitization distance1.01.02.6-1.11.3-1.61.60.30.3-0.90.4-0.81.3-1.20.11.01.00.8
Degree of sensitization stereotypy0.40.41.50.7-1.00.9-1.2-0.40.00.1-0.20.7-0.80.70.5-0.4-0.5-0.1
Conditioned locomotion0.60.81.90.30.00.4-0.30.01.0-0.5-1.21.2-0.90.80.9-1.4-1.4-1.0
Cocaine response after cond. corrected0.70.82.4-1.41.0-1.51.31.50.6-1.1-0.1-0.40.7-0.60.40.50.5-0.1
Cocaine response after cond. not corrected0.20.20.8-0.0-0.5-0.3-0.30.70.3-0.6-0.10.2-0.50.60.90.60.6-0.2
Cocaine response before conditioning2.63.210.02.7-3.02.5-3.2-1.8-1.31.20.50.8-1.91.80.60.40.4-0.1
Saline control response0.40.51.5-0.40.4-0.60.80.6-0.50.30.5-1.20.8-0.7-1.10.50.60.5
Bone: connectivity density0.10.10.50.2-0.10.4-0.1-0.1-0.10.60.4-0.40.2-0.2-0.70.50.50.3
Bone: cortical apparent density0.81.12.9-1.51.2-1.41.71.1-0.0-0.40.5-1.01.4-1.4-0.70.70.70.4
Bone: cortical area2.74.18.92.6-2.42.3-2.1-2.1-3.02.62.2-1.70.6-0.7-1.81.61.61.4
Bone: cortical porosity2.42.65.62.2-2.12.3-2.4-2.0-0.41.1-0.51.3-1.91.70.6-1.4-1.5-0.7
Bone: cortical porosity2.42.64.72.0-1.82.1-2.2-1.70.20.7-1.01.8-2.22.00.9-1.6-1.6-1.0
Bone: cortical thickness1.72.85.91.3-1.61.3-0.9-1.7-2.42.22.1-2.01.3-1.4-2.11.21.21.6
Bone: cortical thickness0.70.82.60.4-0.50.2-0.1-0.6-1.61.10.9-1.51.1-1.1-1.3-0.1-0.10.5
Bone: cortical tissue density0.81.02.8-1.51.2-1.41.71.20.1-0.50.4-0.91.3-1.3-0.60.60.60.3
Condit. Reinf. active minus inactive responses0.10.10.3-0.40.5-0.30.60.30.1-0.40.1-0.00.4-0.40.0-0.1-0.1-0.2
Condit. Reinf. active-inactive response ratio0.30.30.8-0.1-0.0-0.0-0.00.30.9-0.6-0.50.9-0.70.80.70.10.1-0.5
Condit. Reinf. active responses0.81.03.1-0.60.9-0.61.30.1-0.80.20.9-1.21.8-1.8-1.20.50.50.5
Condit. Reinf. inactive responses2.12.57.6-0.51.0-0.71.5-0.2-1.70.71.7-2.22.8-2.7-2.01.01.01.2
Incentive salience index mean0.10.20.60.5-0.30.6-0.4-0.3-0.70.30.5-0.10.5-0.5-0.40.10.1-0.3
Condit. Reinf. lever presses0.71.02.71.1-0.71.3-0.8-0.9-1.61.11.2-0.71.0-1.0-1.10.60.60.0
Condit. Reinf. active minus inactive responses1.41.74.6-0.30.3-0.10.8-0.4-0.91.31.5-1.81.7-1.7-2.11.51.51.7
Condit. Reinf. active-inactive response ratio4.54.710.9-1.31.0-0.91.90.1-1.51.22.4-2.93.3-3.3-2.92.22.22.3
Condit. Reinf. active responses0.50.72.8-0.30.10.20.5-0.4-0.61.00.9-1.01.1-1.1-1.70.40.41.0
Condit. Reinf. inactive responses1.01.32.50.9-0.81.2-1.3-0.60.5-0.0-1.01.5-1.61.50.8-1.4-1.5-1.0
Condit. Reinf. lever presses0.91.32.31.1-1.21.3-1.0-1.1-1.41.51.3-1.00.5-0.6-1.41.01.00.9
Condit. Reinf. lever reinforcers received0.50.72.4-0.50.3-0.10.7-0.1-0.50.80.8-1.11.2-1.2-1.60.40.40.8
Conditioned reinforcement - actives0.20.20.6-0.30.1-0.4-0.00.40.8-0.4-0.60.3-0.60.60.40.10.10.1
Conditioned reinforcement - inactives0.40.51.2-0.70.7-0.80.80.50.30.00.3-0.80.7-0.7-0.80.90.91.1
Conditioned locomotion1.41.62.7-0.70.8-0.80.31.61.5-1.7-1.61.5-1.11.21.6-1.1-1.1-1.6
Patch foraging indifference point 0 sec0.91.53.71.4-1.20.9-0.7-1.2-1.21.21.3-1.00.00.0-0.91.91.91.6
Patch foraging indifference point AUC0.80.92.00.5-1.10.1-0.1-0.9-1.21.11.4-1.30.4-0.4-1.00.90.91.2
Delay disc. indifference point, 0s delay0.40.51.20.7-1.10.4-0.7-0.6-0.80.30.7-0.50.3-0.3-0.10.90.90.7
Delay disc. indifference point, 16s delay0.80.82.4-1.11.1-1.61.41.00.2-0.6-0.4-0.70.9-0.8-0.0-0.8-0.8-0.6
Delay disc. indifference point, 2s delay2.83.14.81.6-2.12.2-1.8-2.1-2.02.12.0-0.80.4-0.6-1.71.91.82.0
Delay disc. indifference point, 24s delay0.50.51.8-1.00.7-1.30.91.30.6-0.9-0.4-0.20.3-0.10.50.10.1-0.4
Delay disc. indifference point, 4s delay0.50.51.2-0.1-0.3-0.10.2-0.0-1.10.31.1-0.91.1-1.1-0.70.80.80.7
Delay disc. indifference point, 8s delay0.00.00.20.0-0.10.3-0.20.1-0.40.10.2-0.00.3-0.3-0.3-0.00.00.0
Indifference point function ln k0.91.22.81.6-1.21.7-1.4-1.3-1.51.11.0-0.50.5-0.6-0.70.80.80.7
Indifference point function log k0.91.22.81.6-1.21.7-1.4-1.3-1.51.11.0-0.50.5-0.6-0.70.80.80.7
Patch foraging total patch changes 0 sec1.11.84.81.2-1.10.7-0.5-1.2-1.41.31.6-1.40.4-0.4-1.12.22.22.0
Patch foraging total patch changes 12 sec0.30.41.5-0.20.3-0.40.70.2-0.20.00.7-0.50.2-0.1-0.41.21.20.8
Patch foraging total patch changes 18 sec0.30.41.1-0.80.3-0.91.00.3-0.3-0.10.7-0.70.6-0.5-0.40.70.70.6
Patch foraging total patch changes 24 sec1.01.23.1-0.30.1-0.40.7-0.3-1.00.71.2-1.41.0-1.0-1.21.71.71.8
Patch foraging total patch changes 6 sec0.81.13.50.0-0.4-0.50.3-0.3-0.81.01.3-1.70.5-0.4-1.31.51.51.9
Patch foraging time to switch 0 sec2.33.57.2-1.82.1-1.51.32.52.1-2.4-2.01.9-0.60.71.9-1.7-1.6-2.7
Patch foraging water rate 0 sec0.50.81.41.1-0.90.6-0.4-0.7-1.21.01.0-1.10.5-0.5-0.81.21.11.1
Patch foraging water rate 12 sec1.01.53.90.9-1.00.6-0.5-1.4-2.01.31.3-1.71.3-1.4-1.40.30.31.2
Patch foraging water rate 18 sec0.60.82.31.4-1.50.9-1.4-1.2-1.31.10.5-0.7-0.20.1-0.30.00.00.2
Patch foraging water rate 24 sec1.11.64.50.8-1.00.6-0.4-0.9-2.11.11.7-1.61.5-1.5-1.21.01.01.3
Patch foraging water rate 6 sec1.31.94.2-0.2-0.0-0.50.6-0.5-1.50.91.6-2.01.8-1.8-1.61.61.61.9
Seeking ratio, delayed vs. immediate footshock1.01.23.9-0.20.30.10.10.60.8-0.6-1.21.2-0.80.91.0-2.0-2.0-1.8
Distance traveled before self-admin0.20.20.9-1.00.8-0.10.20.40.50.1-0.30.10.1-0.1-0.6-0.5-0.50.0
Distance traveled after self-admin0.30.31.2-0.91.10.10.20.60.90.0-0.60.6-0.30.2-0.7-0.3-0.3-0.0
Extensor digitorum longus weight2.610.428.44.9-5.35.1-5.3-4.1-2.63.21.40.6-2.32.1-0.41.21.10.5
Bone: elastic displacement0.91.03.0-0.3-0.0-0.2-0.10.01.5-0.4-1.51.2-1.71.70.8-1.1-1.1-0.7
Bone: elastic work0.20.20.80.3-0.50.7-0.4-0.50.10.9-0.20.0-0.50.5-0.8-0.1-0.10.2
Bone: endosteal estimation0.81.84.52.1-1.81.9-2.0-1.1-1.71.41.0-0.3-0.40.4-0.51.31.30.6
Bone: endosteal perimeter0.51.03.31.8-1.31.6-1.8-0.5-1.10.60.30.4-0.90.80.30.70.6-0.2
Epididymis fat weight0.30.71.71.1-1.10.6-0.7-0.9-1.30.61.1-0.70.4-0.50.01.11.00.8
Delta time in closed arm before/after self-admin1.41.43.6-0.70.7-0.60.61.41.0-1.7-1.31.3-0.30.41.6-1.4-1.4-1.9
Delta time in open arm before/after self-admin5.45.211.31.3-1.51.2-0.8-2.1-2.32.92.8-2.61.2-1.2-2.92.92.93.4
Diff in mean of infusions in LGA sessions1.41.63.9-0.90.7-1.11.30.6-1.10.51.4-2.01.8-1.7-1.51.11.21.1
Delay discount exponential model param0.20.20.40.20.20.2-0.2-0.30.6-0.1-0.60.6-0.70.60.3-0.5-0.5-0.3
Extinction: sum of active levers before priming0.40.41.1-1.00.7-0.90.81.00.7-0.5-0.2-0.10.1-0.0-0.10.60.60.2
Active lever presses in extinction session 60.60.61.31.0-1.10.6-0.8-0.8-0.91.00.8-0.6-0.10.1-0.50.90.90.7
Bone: final force3.55.711.62.9-2.73.0-2.4-2.8-2.93.42.3-1.60.4-0.6-2.61.81.72.2
Bone: final moment3.15.010.32.7-2.42.8-2.2-2.6-2.73.22.2-1.60.4-0.6-2.51.81.82.2
Food consumed during 24 hour testing period1.72.03.60.9-1.31.2-1.0-1.4-1.71.51.8-1.10.7-0.9-1.61.91.91.7
Glucose0.60.82.60.2-1.20.1-0.5-0.7-0.70.61.3-0.7-0.10.1-0.31.51.51.6
Heart weight0.50.72.0-0.60.4-1.41.00.2-0.3-0.50.3-1.21.0-0.90.20.70.81.2
Delay discount hyperbolic model param0.20.30.60.00.4-0.10.0-0.00.7-0.3-0.70.6-0.60.70.6-0.6-0.6-0.5
Intermittent access intake day 1-15 change0.90.92.0-0.40.3-0.70.60.3-0.50.20.9-1.31.2-1.2-0.81.41.41.4
Intermittent access intake escalation0.90.81.7-0.50.4-0.80.70.4-0.4-0.00.8-1.31.3-1.2-0.71.31.31.2
Intermittent access intake escalation 20.80.81.8-0.60.4-1.10.80.7-0.5-0.30.7-1.31.3-1.2-0.31.01.00.7
Intermitt. access day 1 inactive lever presses1.01.12.5-1.31.3-1.61.61.10.4-0.60.2-1.01.3-1.2-0.50.80.80.8
Intermitt. access day 15 inactive lever presses0.30.41.20.8-0.61.1-0.8-1.0-0.60.60.40.00.1-0.3-0.40.20.10.4
Intermitt. access escalation Index0.20.10.50.4-0.30.6-0.4-0.7-0.20.70.1-0.0-0.20.1-0.5-0.3-0.30.0
Intermittent access day 1 total infusions0.20.20.40.3-0.40.1-0.30.0-0.00.60.2-0.3-0.50.5-0.50.70.70.3
Intermittent access day 15 total infusions0.60.72.0-0.30.2-0.80.50.4-0.30.20.8-1.20.8-0.8-0.81.41.41.2
Intermittent access terminal intake (last 3 days)0.60.72.2-0.2-0.1-0.50.20.3-0.30.50.8-1.20.6-0.5-1.01.51.51.2
Intermittent access total infusions0.60.71.40.8-0.90.6-0.7-0.4-0.71.20.8-0.8-0.10.1-1.11.01.00.9
Intermittent access day 1 locomotion0.80.92.00.3-0.30.0-0.0-0.2-1.21.11.3-1.40.8-0.8-1.41.11.11.0
Intermittent access day 15 total locomotion2.12.36.5-0.50.3-1.21.10.4-1.50.71.7-2.62.0-1.8-1.71.81.81.5
Intermittent access total locomotion2.52.95.60.9-1.00.5-0.4-0.9-2.32.02.3-2.41.5-1.5-2.21.91.91.8
Intermittent access standard deviation0.80.92.7-0.2-0.1-1.00.50.4-0.6-0.10.9-1.41.0-0.9-0.31.61.61.2
Left kidney weight2.87.923.14.8-4.54.1-4.2-4.5-2.63.01.2-0.0-1.31.1-0.20.40.30.5
Right kidney weight2.67.221.04.6-4.33.9-4.1-4.2-2.12.71.00.4-1.81.60.20.40.30.4
Cocaine induced anxiety0.30.31.0-0.30.4-0.30.80.0-0.60.20.7-0.71.0-1.0-0.60.00.00.2
Post-drug Anxiety0.00.10.20.3-0.30.10.1-0.4-0.20.40.2-0.2-0.10.1-0.0-0.3-0.30.1
Baseline Anxiety0.70.82.60.9-1.10.7-1.3-0.60.50.3-0.60.8-1.61.60.7-0.0-0.00.1
Tail length1.23.510.83.3-2.82.6-2.7-2.4-1.71.61.00.3-1.61.50.21.11.10.4
Length with tail0.82.96.82.6-1.72.3-2.2-1.7-0.00.9-0.81.8-2.62.51.0-0.7-0.8-1.1
Length without tail0.71.54.10.20.50.6-0.2-0.01.3-0.1-1.71.7-1.41.30.6-2.0-2.0-1.6
Times rat made contact with spout0.30.41.4-0.5-0.10.5-0.10.1-0.60.50.7-0.50.9-1.0-1.20.50.50.5
Lifetime Intake0.30.40.70.6-0.80.5-0.7-0.4-0.10.80.3-0.3-0.50.5-0.60.80.80.7
Liver weight, left0.60.92.51.3-1.60.2-1.0-1.1-0.40.50.6-0.3-1.01.10.61.31.31.0
Liver weight, right0.40.71.61.2-1.30.7-1.0-0.9-0.20.70.50.0-0.80.80.31.21.20.8
Locomotor activity0.60.93.40.5-0.40.5-0.6-0.21.3-0.1-1.21.3-1.81.80.80.0-0.0-0.0
Locomotor testing distance0.20.31.10.3-0.3-0.2-0.10.10.4-0.1-0.1-0.1-0.50.60.31.11.10.7
Locomotor testing rearing0.81.23.7-1.41.4-1.91.81.61.3-1.3-0.8-0.20.3-0.20.50.40.40.2
Locomotion in novel chamber0.81.03.10.2-0.5-0.1-0.3-0.6-1.80.91.5-1.71.0-1.0-1.00.90.91.0
Locomotion in novel chamber post-restriction2.12.55.9-2.11.8-2.22.41.3-0.3-0.30.7-1.92.3-2.2-1.40.60.60.9
Fecal boli incidents, locomotor time 11.81.94.8-1.00.7-1.20.61.51.9-2.0-1.81.5-1.31.42.2-0.7-0.7-1.2
Change in fecal boli incidents, locomotor task1.61.55.51.5-1.61.6-1.1-2.3-1.22.10.8-0.6-0.20.1-1.3-0.3-0.30.3
Time >=10cm from walls, locomotor time 10.20.21.0-0.60.80.30.30.30.8-0.4-0.51.0-0.30.2-0.0-0.3-0.30.1
Bouts of movement, locomotor time 10.20.31.1-0.30.3-0.70.40.70.4-1.0-0.10.3-0.10.21.00.30.3-0.2
Total resting periods, locomotor time 10.20.20.9-0.30.1-0.60.30.70.2-0.9-0.10.3-0.10.21.00.30.3-0.3
Rest time, locomotor task time 11.01.11.9-0.60.4-0.50.31.01.2-1.1-1.31.2-0.91.01.3-1.2-1.2-1.4
Distance moved, locomotor task time 12.52.75.00.4-0.00.20.3-0.9-2.01.52.2-2.21.9-2.0-2.21.92.02.0
Vertical activity count, locomotor time 11.81.94.50.40.20.50.0-0.9-1.41.31.7-1.61.5-1.5-1.91.71.72.1
Time >=10cm from walls, locomotor time 20.30.31.20.3-0.41.0-0.7-0.40.50.1-0.51.1-0.90.80.2-0.2-0.2-0.1
Bouts of movement, locomotor time 20.60.61.7-0.81.1-0.40.91.3-0.4-0.40.4-0.41.3-1.2-0.70.10.1-0.5
Total resting periods, locomotor time 20.30.31.1-0.40.8-0.20.50.9-0.5-0.30.3-0.21.0-1.0-0.5-0.1-0.1-0.6
Rest time, locomotor task time 20.50.51.30.8-1.10.4-0.9-0.60.3-0.1-0.40.7-1.11.11.1-0.4-0.4-0.4
Distance moved, locomotor task time 21.82.14.8-1.11.4-0.51.30.7-0.90.41.4-1.62.2-2.2-1.91.61.61.4
Vertical activity count, locomotor time 21.21.33.3-1.41.8-0.81.30.70.30.00.4-0.81.3-1.3-1.31.11.11.6
Light reinforcement 11.01.93.5-0.90.8-0.60.50.91.8-1.1-1.91.8-1.71.71.5-1.5-1.5-1.4
Light reinforcement 20.10.10.50.7-0.30.5-0.1-0.2-0.10.4-0.10.2-0.50.50.0-0.0-0.0-0.4
Bone: marrow area0.81.74.32.1-1.81.8-1.9-1.1-1.71.41.0-0.3-0.40.4-0.51.31.20.6
Bone: maximum diameter1.62.96.22.5-2.42.1-2.2-1.8-2.52.11.5-0.9-0.10.0-1.11.21.11.1
Bone: maximum force2.95.09.92.9-2.62.9-2.4-2.5-2.83.12.1-1.40.2-0.4-2.31.81.71.8
Bone: maximum moment2.54.38.52.6-2.32.6-2.2-2.3-2.62.92.0-1.40.2-0.3-2.21.71.71.8
Mean time between licks in bursts1.11.55.0-1.81.2-1.51.11.32.2-1.5-1.31.1-0.80.91.00.30.40.1
Mean num. licks in bursts2.83.39.42.2-2.52.9-3.1-1.6-0.21.4-0.11.6-2.72.50.20.30.3-0.1
Cd content in liver2.12.35.6-2.12.4-2.12.11.91.5-1.9-1.20.50.4-0.30.8-0.9-0.9-1.1
Co content in liver0.50.61.71.1-1.00.9-0.8-0.7-0.91.30.5-0.7-0.30.3-0.90.20.20.3
Cu content in liver1.72.06.80.5-0.31.3-0.2-1.4-2.02.01.6-1.31.5-1.7-2.60.20.21.1
Fe content in liver1.11.33.6-1.61.5-1.91.81.50.2-0.60.3-1.21.3-1.1-0.50.60.70.5
K content in liver1.61.64.81.6-1.22.2-1.4-1.8-1.52.00.8-0.0-0.1-0.1-1.4-0.5-0.6-0.0
Mg content in liver0.60.61.51.0-0.51.2-0.8-0.70.00.6-0.50.9-0.90.8-0.0-1.1-1.1-0.9
Mn content in liver0.40.52.01.0-1.20.9-1.4-0.4-0.70.40.30.1-0.70.70.30.20.1-0.0
Na content in liver2.83.08.52.6-2.42.9-2.9-2.3-0.91.50.11.1-1.61.40.1-0.6-0.7-0.2
Rb content in liver0.30.31.40.0-0.30.00.1-0.7-0.70.90.7-0.80.4-0.4-1.20.00.00.7
Se content in liver0.40.51.2-0.10.2-0.00.3-0.0-0.90.70.9-1.01.0-1.0-1.10.70.70.6
Sr content in liver0.30.31.10.3-0.90.4-0.7-0.6-1.10.40.7-0.40.3-0.4-0.3-0.2-0.20.6
Zn content in liver0.80.93.71.3-1.21.9-1.4-1.5-0.60.90.40.7-0.50.3-0.4-0.0-0.10.2
Bone: minimum diameter1.01.94.02.0-1.61.9-1.7-1.2-1.81.61.2-0.6-0.0-0.1-0.91.41.40.7
Time in familiar zone, hab. session 12.52.35.4-0.50.4-1.01.1-0.1-1.80.62.1-2.32.2-2.2-1.41.61.61.6
Time in novel zone, hab. session 14.94.811.50.6-0.41.3-1.60.22.4-1.2-2.83.4-3.13.02.3-2.3-2.4-2.4
Total zone transitions, hab. session 10.91.23.11.5-1.81.2-1.2-1.7-0.91.51.0-0.7-0.20.1-0.90.60.61.2
Total locomotion distance, hab. session 11.52.17.12.1-1.92.1-1.9-2.7-0.81.70.9-0.0-0.60.4-0.60.60.61.4
Locomotion velocity, hab. session 11.21.76.31.8-1.71.7-1.5-2.5-0.61.60.9-0.2-0.40.2-0.70.70.61.6
Time in familiar zone, hab. session 22.62.75.50.1-0.40.10.2-0.3-2.21.32.4-2.22.0-2.0-2.02.02.11.8
Time in novel zone, hab. session 21.61.63.8-0.30.5-0.40.10.31.9-1.2-1.81.6-1.41.41.6-1.4-1.4-1.1
Total zone transitions, hab. session 20.60.81.91.2-1.41.0-1.3-1.00.20.8-0.30.3-1.41.40.1-0.1-0.10.1
Total locomotion distance, hab. session 20.50.72.11.1-1.11.3-1.3-1.5-0.11.00.20.3-0.80.7-0.20.20.10.6
Locomotion velocity, hab. session 20.81.13.11.4-1.41.7-1.6-1.8-0.21.30.30.3-0.90.7-0.40.10.10.7
Novel to familiar place preference ratio1.21.24.1-1.62.0-1.41.81.21.6-1.1-0.90.40.2-0.20.2-0.2-0.1-0.0
Novelty place preference1.11.14.0-1.62.0-1.41.91.21.4-0.9-0.60.20.4-0.4-0.0-0.0-0.00.1
Time in novel zone, NPP test1.31.34.5-1.72.1-1.62.01.31.4-1.0-0.60.10.6-0.5-0.00.10.20.3
Total zone transitions, NPP test0.91.34.11.8-2.01.5-1.8-1.5-1.01.30.6-0.3-0.60.5-0.30.20.10.3
Total locomotion distance, NPP test0.50.72.51.4-1.31.1-1.2-1.6-0.60.70.5-0.0-0.20.10.10.50.50.7
Locomotion velocity, NPP test0.71.03.11.7-1.71.4-1.6-1.8-0.60.90.30.2-0.60.50.20.10.10.4
Intraocular pressure1.11.64.0-1.40.9-1.00.71.32.0-0.9-1.80.8-0.80.90.3-1.8-1.7-1.2
Delta distance traveled before/after self-admin0.10.20.7-0.40.8-0.10.60.50.4-0.2-0.40.40.1-0.1-0.2-0.4-0.4-0.3
Delta ambulatory time before/after self-admin0.10.10.7-0.30.90.00.50.30.30.0-0.20.20.2-0.3-0.5-0.3-0.3-0.1
Parametrial fat weight3.67.014.23.2-3.62.3-2.3-3.3-3.82.93.4-2.20.8-1.0-1.42.62.52.1
Pavlov. Cond. lever latency0.91.23.5-1.71.8-1.91.81.30.9-1.0-0.6-0.40.7-0.60.1-0.1-0.10.3
Pavlov. Cond. magazine entry latency0.70.92.01.4-1.11.1-1.4-0.90.0-0.2-0.21.2-1.21.11.2-0.1-0.1-0.3
Pavlov. Cond. change in total contacts1.01.12.31.0-0.91.4-1.4-0.30.0-0.2-0.71.5-1.31.20.9-1.0-1.0-1.5
Pavlov. Cond. index score0.50.61.91.3-1.21.2-1.4-0.8-0.50.20.20.7-0.70.60.6-0.1-0.1-0.4
Pavlov. Cond. latency score0.70.92.81.6-1.61.5-1.7-1.1-0.70.50.40.6-0.80.70.40.10.1-0.3
Pavlov. Cond. lever contacts0.80.92.81.5-1.51.7-1.7-1.0-0.60.50.30.7-0.80.70.3-0.1-0.1-0.5
Pavlov. Cond. magazine entry number0.50.61.8-0.60.6-0.60.90.1-0.40.80.6-1.31.1-1.0-1.30.40.40.6
Pavlov. Cond. intertrial magazine entries0.80.92.3-0.81.1-1.11.50.6-0.50.20.7-1.41.4-1.2-1.10.60.60.6
Pavlov. Cond. lever-magazine prob. diff.0.50.61.91.2-1.31.3-1.4-0.9-0.50.30.30.7-0.70.60.40.0-0.0-0.2
Pavlov. Cond. response bias0.50.61.60.8-0.70.8-1.0-0.30.3-0.6-0.41.3-1.00.91.2-0.4-0.4-0.7
Pavlov. Cond. lever latency0.81.12.5-0.81.1-0.80.70.91.6-1.1-1.41.1-0.80.91.1-1.0-1.0-1.0
Pavlov. Cond. magazine entry latency1.41.64.3-1.41.2-1.71.11.81.4-2.1-1.10.9-0.50.61.7-0.5-0.5-0.9
Pavlov. Cond. change in total contacts0.20.30.9-0.10.2-0.40.50.2-0.40.30.6-0.90.6-0.5-0.70.80.80.7
Pavlov. Cond. index score0.20.20.5-0.40.2-0.70.60.6-0.2-0.50.4-0.50.6-0.50.10.60.60.3
Pavlov. Cond. latency score0.10.10.3-0.10.0-0.50.30.4-0.3-0.40.4-0.30.3-0.30.20.50.50.2
Pavlov. Cond. lever contacts0.81.12.21.2-1.51.1-1.1-1.2-1.41.31.2-0.90.3-0.3-1.00.80.80.8
Pavlov. Cond. magazine entry number1.11.33.11.7-1.61.8-1.7-1.6-0.71.50.6-0.0-0.60.5-0.50.80.70.7
Pavlov. Cond. intertrial magazine entries1.92.56.42.5-2.32.4-2.4-2.3-1.41.71.10.1-0.80.6-0.50.90.80.7
Pavlov. Cond. lever-magazine prob. diff.0.20.20.7-0.60.5-0.80.70.80.1-0.80.1-0.20.3-0.30.40.40.40.0
Pavlov. Cond. response bias0.20.30.8-0.4-0.0-0.30.40.1-0.60.10.7-0.80.9-0.9-0.70.30.30.4
Time in closed arm before self-admin0.60.71.9-0.90.8-1.41.00.40.0-0.60.4-1.01.1-1.1-0.10.80.81.0
Time in closed arm after self-admin2.02.14.6-1.41.5-2.11.81.81.0-2.1-1.10.30.5-0.31.6-1.4-1.3-1.6
Time in open arm before self-admin2.02.15.20.7-0.41.0-1.00.11.0-0.2-1.61.8-2.02.01.1-2.0-2.0-2.3
Time in open arm after self-admin3.23.68.01.6-1.62.1-1.7-1.9-2.02.82.0-1.50.3-0.5-2.61.91.92.2
Bone: periosteal estimation2.45.011.13.1-2.82.7-2.6-2.0-3.32.72.3-1.50.4-0.5-1.72.12.11.3
Bone: periosteal perimeter0.91.64.92.2-1.91.8-2.1-1.2-1.51.10.60.1-0.90.80.10.60.60.1
Bone: post-yield work3.14.28.82.8-3.02.8-2.9-2.8-2.82.32.1-0.6-0.30.1-0.81.21.11.3
Progressive ratio test 1 active lever presses0.10.20.50.2-0.10.10.0-0.30.00.70.2-0.4-0.10.2-0.70.50.50.7
Progressive ratio test 1 breakpoint0.20.20.80.2-0.20.10.0-0.4-0.20.80.4-0.6-0.00.1-0.90.60.60.8
Progressive ratio test 1 inactive lever presses0.20.20.50.5-0.30.7-0.4-0.6-0.30.60.4-0.20.2-0.3-0.60.40.40.7
Progressive ratio test 2 active lever presses0.20.21.0-0.60.6-0.80.71.00.6-0.4-0.3-0.20.00.1-0.00.30.30.0
Progressive ratio test 2 breakpoint0.10.10.6-0.30.3-0.50.40.70.3-0.1-0.0-0.30.10.0-0.30.30.30.1
Progressive ratio test 2 inactive lever presses0.10.10.30.4-0.30.0-0.20.10.3-0.1-0.20.1-0.50.60.20.20.2-0.1
Incentive Sensitization - Responses0.30.31.4-0.30.3-0.40.21.20.8-0.8-0.60.5-0.50.60.60.10.1-0.6
Incentive Sensitization - Breakpoint0.20.20.9-0.00.0-0.1-0.10.90.6-0.5-0.50.4-0.60.70.40.20.2-0.5
Sum of active levers in priming session hrs 5-61.71.64.11.3-1.71.8-2.0-1.20.30.8-0.51.2-1.91.80.4-0.6-0.7-0.8
Progressive ratio0.50.51.80.5-0.60.0-0.7-0.20.8-0.4-0.80.8-1.31.41.1-0.2-0.2-0.2
Food seeking constrained by brief footshock0.10.10.40.00.0-0.3-0.30.10.6-0.2-0.20.2-0.50.60.30.20.20.1
Seeking ratio, punishment vs. effort0.10.10.6-0.00.10.5-0.2-0.2-0.30.50.4-0.20.3-0.4-0.80.20.20.2
Retroperitoneal fat weight0.10.51.20.8-0.8-0.4-0.1-1.0-0.40.00.6-0.4-0.10.10.81.11.10.9
Reaction time number correct1.01.42.6-1.51.3-1.31.11.61.6-1.5-1.30.9-0.40.51.0-0.9-0.8-1.0
Reaction time mean minus median0.10.10.40.3-0.70.3-0.3-0.5-0.20.10.30.1-0.30.20.10.10.10.5
Reaction time mean minus median AUC0.10.10.3-0.3-0.1-0.20.2-0.10.4-0.1-0.20.2-0.40.40.1-0.5-0.50.2
Reaction time num false alarms0.20.30.6-0.80.7-0.70.60.40.3-0.00.0-0.60.8-0.8-0.50.30.40.4
Reaction time num false alarms AUC0.00.00.1-0.10.10.0-0.1-0.00.10.3-0.1-0.30.3-0.3-0.30.10.10.1
Reaction time trials correct on left1.01.42.6-1.51.3-1.31.11.61.6-1.5-1.30.9-0.40.51.0-0.9-0.8-1.0
Reaction time trials on left1.01.42.6-1.51.2-1.31.01.61.6-1.5-1.30.9-0.40.51.1-0.9-0.9-1.0
Reaction time mean0.60.82.50.6-0.60.7-0.7-0.61.00.0-0.91.3-1.61.50.7-0.7-0.7-0.1
Reaction time mean AUC0.91.13.30.6-0.60.7-0.7-0.51.3-0.1-1.21.5-1.81.80.9-1.1-1.1-0.5
Median of all reaction times0.71.02.90.7-0.60.8-0.7-0.61.20.1-1.11.4-1.71.60.7-0.8-0.9-0.3
Reaction time omissions1.42.04.30.3-1.00.8-1.30.31.3-0.9-1.62.1-2.12.01.8-1.4-1.4-1.5
Reaction time false alarm rate0.20.30.60.3-0.20.3-0.3-0.4-0.50.70.5-0.80.6-0.7-0.70.70.70.5
Reaction time premature initiation rate2.12.86.20.3-0.61.1-1.6-0.01.3-0.8-2.02.5-2.22.11.7-2.2-2.2-1.8
Reaction time premature initiations3.14.49.4-0.40.10.4-1.00.82.2-1.6-2.73.1-2.42.42.3-2.9-2.9-2.5
Std. dev. reaction times0.20.31.00.6-0.80.4-0.6-0.50.3-0.1-0.20.6-1.01.00.7-0.2-0.20.1
Reaction time trials completed1.01.42.6-1.51.2-1.31.01.61.6-1.5-1.30.9-0.40.51.1-0.9-0.9-1.0
Reaction time trials AUC0.81.22.3-1.41.2-1.21.01.51.5-1.4-1.20.8-0.40.41.0-0.8-0.7-0.9
Run reversals in cocaine runway, females2.42.37.32.4-2.22.5-2.7-2.0-0.61.40.00.7-1.41.20.0-0.4-0.4-0.1
Run reversals in cocaine runway, males0.30.31.30.30.00.7-0.3-0.3-0.00.3-0.40.3-0.1-0.0-0.4-1.1-1.1-0.7
Latency to leave start box in cocaine runway1.31.43.00.6-0.70.5-0.3-1.5-1.71.61.5-1.61.1-1.1-1.50.70.61.3
Latency to leave start box in cocaine runway, F0.30.41.1-0.30.1-0.60.70.1-0.90.10.6-0.91.1-1.0-0.40.10.10.1
Latency to leave start box in cocaine runway, M0.90.92.80.9-0.71.0-0.9-1.7-0.81.70.7-0.70.0-0.1-1.10.30.31.2
Std. dev. time between licks in bursts0.20.31.1-0.50.2-0.60.40.10.4-0.10.1-0.30.00.0-0.21.01.10.9
Total sessions with >9 infusions0.10.10.50.3-0.30.5-0.40.20.20.3-0.30.4-0.70.7-0.2-0.1-0.1-0.3
Short access day 1 total inactive lever presses1.21.32.70.7-0.40.6-1.00.30.8-0.3-1.31.4-1.61.61.1-1.4-1.4-1.6
Short access day 10 total inactive lever presses0.40.51.2-0.91.0-0.81.00.70.1-0.30.1-0.61.1-1.1-0.5-0.00.00.2
Short access day 1 total infusions1.31.44.3-0.70.6-0.50.10.92.1-1.0-1.71.5-1.51.51.1-0.8-0.8-0.9
Short access day 10 total infusions0.20.20.4-0.60.6-0.40.60.60.2-0.00.2-0.40.4-0.4-0.60.50.50.5
Short access total infusions0.30.30.90.5-0.60.5-0.7-0.40.50.4-0.20.3-0.90.9-0.10.40.40.4
Short access day 1 locomotion1.01.13.0-1.61.7-1.01.41.61.2-0.7-0.90.40.2-0.1-0.3-1.0-1.0-0.8
Short access day 10 total locomotion2.22.55.2-0.30.2-0.20.8-0.1-1.81.12.1-2.22.3-2.3-2.21.61.61.7
Short access total locomotion1.71.73.40.4-0.50.10.0-0.6-1.41.51.7-1.91.1-1.1-1.81.61.61.8
One hour access (0.3 mA shock)1.51.85.80.1-0.5-0.60.4-0.3-1.00.71.7-1.81.0-1.0-1.02.42.42.1
Compulsive drug intake0.10.10.40.6-0.60.4-0.4-0.6-0.10.00.10.4-0.40.40.50.0-0.00.1
One hour access (shock baseline)0.81.02.2-0.70.4-1.10.90.5-0.30.20.9-1.51.0-0.9-0.91.41.41.3
Social response proportion0.60.61.5-0.91.0-1.20.90.81.2-1.2-0.80.3-0.20.30.90.00.10.3
Social responses0.40.51.4-0.60.4-1.00.50.80.8-1.2-0.60.4-0.60.71.10.00.00.0
Social time0.60.82.6-1.30.9-1.61.21.01.2-1.2-0.80.1-0.40.60.90.10.10.3
Soleus weight2.05.711.73.4-3.12.8-2.5-3.2-2.92.92.3-1.60.2-0.4-1.62.12.02.0
Bone: stiffness4.46.913.73.4-2.83.1-2.6-2.9-3.73.62.8-2.10.9-1.0-2.62.01.92.0
Tibialis anterior weight4.113.932.75.5-5.75.6-5.5-5.5-3.34.52.4-0.4-1.71.4-1.71.71.61.9
Time to tail flick, vehicle, before self-admin0.10.10.70.5-0.80.3-0.7-0.3-0.20.20.2-0.1-0.40.40.10.30.3-0.1
Time to tail flick, vehicle, after self-admin0.10.10.40.6-0.4-0.10.0-0.1-0.0-0.10.00.1-0.30.40.5-0.1-0.1-0.5
Time to tail flick, test, before self-admin0.70.61.81.2-1.31.3-1.3-1.1-0.40.40.20.5-0.70.60.20.40.40.0
Time to tail flick, test, after self-admin1.01.13.8-0.70.8-1.21.30.4-0.8-0.71.1-1.12.0-1.9-0.00.40.40.2
Delta time to tail flick, vehicle, before/after SA0.10.10.30.40.00.20.3-0.3-0.60.50.5-0.50.5-0.5-0.50.10.10.1
Delta time to tail flick, test, before/after SA0.90.82.8-0.70.8-1.01.00.3-0.7-0.40.8-1.11.7-1.7-0.20.30.30.6
Tibia length0.10.10.50.20.0-0.00.2-0.2-0.40.20.5-0.40.2-0.2-0.20.70.70.5
Ambulatory time before self-admin0.30.31.0-1.01.0-0.40.70.60.20.1-0.1-0.30.6-0.5-0.9-0.4-0.4-0.1
Ambulatory time after self-admin0.50.51.7-1.11.30.00.40.91.1-0.1-0.90.7-0.30.3-0.6-0.7-0.7-0.5
Bone: tissue strength0.40.40.80.1-0.30.8-0.6-0.50.60.4-0.60.8-0.80.7-0.0-0.9-0.9-0.3
Total heroin consumption0.30.41.8-0.1-0.4-0.3-0.40.50.9-0.2-0.60.4-1.21.40.50.40.4-0.4
Bone: trabecular number0.30.40.90.7-0.60.6-0.4-0.8-0.61.00.7-0.70.3-0.3-0.80.70.70.8
Bone: trabecular spacing1.21.63.4-0.30.2-0.1-0.20.71.5-1.2-1.61.8-1.51.51.7-1.4-1.4-1.6
Bone: trabecular thickness1.31.62.81.3-1.10.6-0.7-1.3-1.61.41.4-1.50.6-0.5-1.11.71.71.5
Bone: trabecular tissue density0.40.51.81.3-0.80.9-1.0-0.7-0.30.6-0.10.3-1.01.00.20.30.3-0.5
Water consumed over 24 hours0.80.92.9-1.31.2-0.80.81.70.6-1.2-0.80.50.3-0.30.4-1.0-1.0-1.2
Number of responses in last shaping day0.50.51.60.3-0.20.3-0.5-0.21.1-0.1-1.00.9-1.31.20.5-0.4-0.4-0.3