Hub : Genes

Tnrc6a

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Brain gene expression Tnrc6a 0.26 0.12 9.0e-13 0.1 0.12 0.12 0.13 1.4e-09 3.3e-11 1.7e-11 6.6e-12
2 PL gene expression Tnrc6a 0.08 0.04 5.2e-11 0.06 0.09 0.07 0.07 2.8e-07 5.1e-10 1.3e-08 5.6e-08
3 NAcc gene expression Tnrc6a 0.02 0.01 2.5e-03 0 0.01 0.01 0.01 1.2e-01 3.0e-02 1.2e-02 2.3e-02
4 Adipose mRNA stability Tnrc6a 0.24 0.12 3.7e-11 0.05 0.08 0.08 0.08 1.3e-06 1.4e-09 4.3e-09 4.7e-09
5 PL intron excision ratio chr1_187020878_187097468 0.04 0.03 6.1e-03 0 0.01 -0 -0 1.6e-01 6.5e-02 4.3e-01 4.2e-01
6 Brain isoform ratio XM_063263194.1 0.04 0.03 8.5e-03 0.01 -0 -0 0 6.5e-02 4.2e-01 3.7e-01 1.1e-01
7 BLA isoform ratio XM_063263194.1 0.06 0.04 7.4e-03 0.03 0.03 0.01 0.02 1.0e-02 1.7e-02 9.6e-02 2.4e-02
8 pVTA gene expression Tnrc6a 0.05 0.03 5.2e-04 0.04 0.04 0.04 0.04 2.4e-04 7.3e-04 2.8e-04 4.9e-04
9 Brain mRNA stability Tnrc6a 0.2 0.09 2.9e-10 0.11 0.12 0.12 0.12 2.4e-10 4.0e-11 2.6e-11 9.8e-12
10 PL intron excision ratio chr1_187132291_187133076 0.04 0.03 1.1e-03 0.01 0.01 0 0.01 1.5e-02 7.9e-03 1.0e-01 5.3e-02
11 PL intron excision ratio chr1_187132291_187132771 0.03 0.02 6.4e-03 -0 -0 -0 -0 6.8e-01 5.4e-01 7.9e-01 9.9e-01
12 PL intron excision ratio chr1_187105005_187114341 0.17 0.14 8.8e-03 -0 0.01 0.01 0.01 5.9e-01 2.6e-02 5.7e-02 3.2e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12
Bone: apparent density0.40.82.00.70.9-0.41.10.91.01.40.01.10.7-0.7-1.1
Area under the delay curve0.10.20.6-0.2-0.1-0.20.20.40.4-0.10.40.40.7-0.7-0.8
BMI with tail1.96.711.82.92.6-2.73.03.33.41.6-0.13.12.7-2.6-0.7
BMI without tail1.68.413.53.43.1-3.13.33.53.72.30.13.52.8-2.6-1.1
Body weight1.56.516.84.13.6-3.63.02.72.61.6-1.81.91.1-0.8-0.3
Weight adjusted by age0.00.10.60.30.10.20.10.30.1-0.10.40.20.7-0.8-0.0
Bone surface0.61.13.21.31.8-1.21.60.60.71.1-0.50.60.6-0.6-1.0
Bone volume0.81.63.31.51.8-1.31.71.01.01.6-0.21.10.9-0.9-1.2
Breakpoint value in progressive ratio session0.10.30.6-0.5-0.50.4-0.40.1-0.70.70.6-0.5-0.20.3-0.8
Number of licking bursts1.44.410.7-3.3-3.13.1-1.5-0.5-0.7-1.22.90.01.7-2.0-1.8
Context. condit. distance diff. score0.60.71.9-0.9-1.01.0-0.70.1-0.1-1.41.40.10.8-0.9-0.7
Locomotion velocity, session 10.20.20.70.10.5-0.20.30.10.10.80.50.30.3-0.3-0.8
Locomotion distance, session 10.10.10.30.30.4-0.50.30.50.20.3-0.30.20.4-0.4-0.4
Locomotion velocity, session 20.30.31.60.30.3-0.30.50.60.10.40.10.10.8-0.8-1.3
Locomotion distance, session 20.30.50.70.70.9-0.70.80.50.90.7-0.70.70.4-0.40.2
Locomotion velocity, session 30.91.13.21.51.6-1.81.30.50.90.3-1.30.60.00.10.3
Locomotion distance, session 30.20.20.50.40.7-0.70.5-0.40.0-0.2-0.7-0.1-0.10.1-0.3
Stereotopy head waving bouts, day 30.40.43.7-0.20.20.00.30.30.51.90.70.7-0.20.30.2
Stereotopy head waving duration, day 30.40.53.50.10.6-0.40.80.60.61.90.00.70.10.0-0.1
Locomotion velocity, session 71.61.73.10.90.8-1.1-0.8-1.4-1.0-1.7-1.4-0.9-1.71.71.8
Locomotion distance, session 70.40.52.2-0.7-0.61.0-0.9-0.9-0.8-1.50.1-0.4-0.1-0.10.3
Stereotopy head waving bouts, day 70.20.20.60.40.6-0.80.2-0.0-0.00.4-0.4-0.1-0.50.60.2
Stereotopy head waving duration, day 70.60.72.61.11.4-1.60.80.20.50.8-0.70.3-0.40.50.5
Locomotion velocity, session 80.20.20.50.40.4-0.20.50.40.70.6-0.00.60.2-0.2-0.6
Locomotion distance, session 80.20.30.9-0.3-0.20.30.10.30.4-0.70.30.50.8-0.9-0.5
Degree of sensitization distance0.80.92.6-1.1-1.51.6-0.90.4-0.0-0.51.30.40.7-0.7-0.0
Degree of sensitization stereotypy0.40.41.30.80.9-1.10.1-0.4-0.1-0.3-0.7-0.4-0.60.70.6
Conditioned locomotion0.50.51.40.10.20.0-0.5-1.1-0.3-0.5-1.0-0.6-1.01.01.2
Cocaine response after cond. corrected0.50.72.2-1.4-1.51.3-0.9-0.1-0.4-0.51.1-0.20.4-0.5-0.6
Cocaine response after cond. not corrected0.00.00.20.0-0.3-0.1-0.40.3-0.2-0.3-0.0-0.1-0.10.1-0.2
Cocaine response before conditioning2.02.47.62.82.5-2.71.20.70.40.5-1.90.0-0.70.90.4
Saline control response0.81.14.3-0.6-0.50.80.20.70.51.61.40.71.0-1.0-2.1
Bone: connectivity density0.20.30.6-0.10.5-0.10.70.30.70.80.10.80.5-0.5-0.7
Bone: cortical apparent density0.50.82.0-1.2-1.21.4-0.4-0.1-0.6-0.41.1-0.30.7-0.8-1.0
Bone: cortical area2.54.17.62.42.5-2.12.82.12.01.9-0.51.71.8-1.7-1.7
Bone: cortical porosity2.52.79.12.32.2-2.71.2-0.10.1-0.3-3.0-0.7-1.11.21.3
Bone: cortical porosity2.42.78.02.12.0-2.50.7-0.5-0.4-0.3-2.8-1.1-1.61.71.5
Bone: cortical thickness1.62.75.21.11.3-1.02.31.91.71.70.31.62.1-2.1-1.7
Bone: cortical thickness0.91.13.30.40.3-0.11.11.20.90.50.10.91.5-1.5-1.8
Bone: cortical tissue density0.50.82.1-1.3-1.21.4-0.5-0.1-0.6-0.41.1-0.30.6-0.8-0.9
Condit. Reinf. active minus inactive responses0.20.20.8-0.3-0.40.4-0.6-0.5-0.9-0.40.7-0.7-0.0-0.00.1
Condit. Reinf. active-inactive response ratio0.40.41.0-0.0-0.1-0.1-0.7-0.6-1.0-0.40.3-0.7-0.90.90.8
Condit. Reinf. active responses0.40.51.6-0.5-0.61.00.10.2-0.30.31.1-0.01.1-1.3-0.9
Condit. Reinf. inactive responses1.21.65.2-0.5-0.61.10.80.90.81.01.01.02.1-2.3-1.7
Incentive salience index mean0.10.20.40.60.6-0.60.2-0.3-0.7-0.3-0.0-0.60.1-0.20.0
Condit. Reinf. lever presses0.40.61.91.11.4-1.21.10.20.00.1-0.5-0.10.7-0.8-0.3
Condit. Reinf. active minus inactive responses1.42.14.7-0.20.10.51.41.31.72.11.12.21.9-1.9-1.2
Condit. Reinf. active-inactive response ratio2.23.58.5-1.3-0.81.41.11.41.51.62.22.22.8-2.9-1.8
Condit. Reinf. active responses0.71.02.8-0.30.30.21.20.51.41.70.31.61.2-1.2-0.3
Condit. Reinf. inactive responses0.81.22.90.81.2-1.20.2-1.00.1-0.0-1.7-0.4-1.41.41.7
Condit. Reinf. lever presses1.11.53.70.81.2-0.81.61.01.61.9-0.01.61.2-1.2-0.7
Condit. Reinf. lever reinforcers received0.60.92.3-0.5-0.00.50.90.41.21.50.61.41.2-1.2-0.5
Conditioned reinforcement - actives0.20.61.4-0.5-0.60.3-1.2-1.1-0.8-0.60.4-0.7-1.01.00.5
Conditioned reinforcement - inactives0.30.72.3-1.3-1.11.2-0.8-0.6-0.50.31.5-0.10.2-0.3-0.4
Conditioned locomotion1.11.63.2-0.7-0.90.6-1.7-1.8-1.7-1.10.1-1.6-1.51.50.6
Patch foraging indifference point 0 sec0.51.53.11.30.9-0.41.11.61.71.40.91.81.0-0.9-1.0
Patch foraging indifference point AUC0.61.43.90.70.4-0.61.32.01.31.50.51.31.4-1.2-1.1
Delay disc. indifference point, 0s delay0.30.41.00.50.4-1.00.20.41.0-0.10.61.00.4-0.40.2
Delay disc. indifference point, 16s delay0.70.92.5-1.2-1.61.3-0.60.2-0.7-1.00.2-0.70.6-0.7-1.4
Delay disc. indifference point, 2s delay2.62.95.61.72.3-2.02.11.12.41.9-0.12.31.0-0.80.8
Delay disc. indifference point, 24s delay0.40.61.7-0.8-1.20.7-0.90.2-0.6-0.50.9-0.40.2-0.3-1.3
Delay disc. indifference point, 4s delay0.30.30.8-0.3-0.2-0.30.20.20.6-0.40.70.70.8-0.9-0.4
Delay disc. indifference point, 8s delay0.00.10.40.00.4-0.60.2-0.40.2-0.1-0.10.20.0-0.10.1
Indifference point function ln k0.30.82.31.31.5-1.31.00.41.0-0.2-0.40.90.6-0.60.2
Indifference point function log k0.30.82.31.31.5-1.31.00.41.0-0.2-0.40.90.6-0.60.2
Patch foraging total patch changes 0 sec0.72.04.21.10.7-0.21.12.01.91.51.32.11.5-1.3-1.3
Patch foraging total patch changes 12 sec0.30.41.9-0.3-0.50.8-0.10.60.20.81.40.40.5-0.5-0.7
Patch foraging total patch changes 18 sec0.30.71.7-0.6-0.91.0-0.10.90.40.81.30.60.9-0.8-0.8
Patch foraging total patch changes 24 sec0.41.32.5-0.2-0.50.90.41.51.01.41.61.31.4-1.3-1.1
Patch foraging total patch changes 6 sec1.72.95.90.0-0.30.61.02.31.82.42.02.11.9-1.7-2.3
Patch foraging time to switch 0 sec1.35.010.1-1.9-1.81.7-2.5-2.8-3.2-2.7-0.6-3.0-2.11.81.2
Patch foraging water rate 0 sec0.41.52.61.00.8-0.61.01.51.31.31.01.51.3-1.2-1.6
Patch foraging water rate 12 sec0.31.42.80.70.6-0.51.21.31.50.40.51.51.7-1.7-1.1
Patch foraging water rate 18 sec0.41.01.91.40.9-1.31.11.40.80.3-0.80.60.8-0.7-1.1
Patch foraging water rate 24 sec0.60.92.20.50.6-0.61.01.21.00.40.11.11.5-1.5-0.9
Patch foraging water rate 6 sec1.32.03.8-0.3-0.50.50.71.61.51.31.81.91.9-1.9-1.4
Seeking ratio, delayed vs. immediate footshock0.81.12.8-0.00.00.1-0.5-1.2-1.4-1.2-1.6-1.7-1.21.10.2
Distance traveled before self-admin0.20.30.8-0.7-0.30.2-0.3-0.9-0.8-0.1-0.4-0.8-0.70.70.5
Distance traveled after self-admin0.30.62.1-1.2-0.20.5-0.4-1.4-0.70.50.3-0.6-0.80.80.5
Extensor digitorum longus weight2.49.631.15.05.3-5.63.41.71.72.0-2.81.0-0.10.40.4
Bone: elastic displacement0.40.51.6-0.3-0.40.3-0.6-0.5-0.80.5-0.2-1.1-1.21.30.4
Bone: elastic work0.30.42.60.30.6-0.30.90.30.31.6-0.00.20.1-0.1-0.6
Bone: endosteal estimation0.61.64.32.12.1-1.61.41.01.01.2-0.70.90.4-0.3-0.6
Bone: endosteal perimeter0.40.93.31.81.8-1.60.70.20.1-0.1-1.1-0.2-0.40.4-0.2
Epididymis fat weight0.31.53.01.61.4-1.41.41.71.40.5-0.21.11.2-1.2-0.5
Delta time in closed arm before/after self-admin1.91.84.5-0.20.1-0.0-1.1-2.1-1.4-1.7-0.8-1.6-1.61.41.7
Delta time in open arm before/after self-admin3.74.49.71.21.3-1.02.42.72.53.10.82.62.2-2.0-1.9
Diff in mean of infusions in LGA sessions0.61.12.7-0.5-0.40.70.71.30.61.20.90.81.4-1.4-1.7
Delay discount exponential model param0.10.10.30.30.20.2-0.0-0.2-0.20.4-0.4-0.3-0.50.50.6
Extinction: sum of active levers before priming0.30.40.9-0.9-0.80.9-0.7-0.3-0.90.40.9-0.7-0.30.3-0.4
Active lever presses in extinction session 60.90.91.61.21.3-1.11.31.00.91.3-0.60.80.3-0.2-0.3
Bone: final force3.86.212.42.73.2-2.53.52.23.02.9-0.72.81.9-1.7-1.2
Bone: final moment3.55.711.22.52.9-2.23.32.22.83.0-0.52.71.9-1.7-1.4
Food consumed during 24 hour testing period0.81.73.81.01.3-1.11.61.01.91.50.32.01.2-1.1-0.2
Glucose0.30.51.30.50.2-0.50.21.11.00.80.91.10.4-0.2-0.0
Heart weight0.30.52.01.00.3-0.50.31.40.90.10.20.80.7-0.6-0.7
Delay discount hyperbolic model param0.10.20.40.0-0.20.4-0.4-0.3-0.5-0.0-0.4-0.6-0.60.60.5
Intermittent access intake day 1-15 change0.31.44.4-1.5-1.71.6-1.10.1-0.2-0.62.10.40.8-0.9-1.0
Intermittent access intake escalation0.21.33.9-1.4-1.61.5-0.90.2-0.1-0.52.00.40.9-1.0-1.3
Intermittent access intake escalation 20.71.22.7-1.4-1.61.5-1.00.1-0.5-0.81.6-0.10.7-0.8-1.2
Intermitt. access day 1 inactive lever presses0.11.23.9-1.4-1.31.5-0.30.20.30.32.00.81.2-1.3-0.8
Intermitt. access day 15 inactive lever presses0.00.30.80.70.9-0.60.5-0.10.60.2-0.00.60.3-0.30.4
Intermitt. access escalation Index0.10.20.60.10.00.10.60.70.30.8-0.00.30.6-0.6-0.6
Intermittent access day 1 total infusions0.20.52.1-0.1-0.10.30.20.60.11.41.00.20.6-0.5-1.3
Intermittent access day 15 total infusions0.71.75.5-1.4-1.51.6-0.70.5-0.10.42.30.51.2-1.3-1.8
Intermittent access terminal intake (last 3 days)0.81.34.2-1.0-1.01.2-0.30.70.11.02.00.51.1-1.1-1.9
Intermittent access total infusions0.50.62.70.10.20.10.50.70.21.50.80.40.7-0.7-1.6
Intermittent access day 1 locomotion0.30.62.8-0.3-0.30.50.20.6-0.00.90.80.10.9-0.9-1.7
Intermittent access day 15 total locomotion0.51.96.3-1.0-1.11.40.01.10.21.01.80.51.7-1.8-2.5
Intermittent access total locomotion1.01.24.30.20.20.10.91.30.61.60.80.71.4-1.4-2.1
Intermittent access standard deviation0.21.13.2-0.3-0.40.4-0.01.10.70.31.81.11.3-1.3-1.7
Left kidney weight1.29.529.35.44.6-5.13.12.62.50.9-3.41.40.10.30.9
Right kidney weight1.28.725.05.04.2-4.53.23.02.91.3-2.72.10.6-0.20.7
Cocaine induced anxiety0.10.30.8-0.9-0.90.9-0.6-0.4-0.4-0.60.4-0.20.1-0.20.3
Post-drug Anxiety0.10.10.30.1-0.20.10.20.50.1-0.0-0.50.10.1-0.00.2
Baseline Anxiety0.60.92.31.51.3-1.51.11.10.70.9-1.10.40.00.1-0.5
Tail length0.31.96.52.61.9-1.81.21.51.31.3-0.71.10.2-0.0-0.5
Length with tail0.62.87.52.62.1-2.30.7-0.1-0.20.1-2.7-0.8-1.82.00.7
Length without tail0.52.48.31.50.8-1.3-0.3-0.5-1.0-1.0-2.9-1.6-2.12.31.1
Times rat made contact with spout0.20.20.4-0.40.4-0.30.4-0.60.40.60.50.60.5-0.6-0.5
Lifetime Intake0.30.31.80.20.3-0.10.40.50.31.30.60.40.4-0.3-0.9
Liver weight, left0.30.62.60.4-0.7-0.1-0.71.60.30.11.20.60.3-0.1-1.2
Liver weight, right0.20.41.10.5-0.2-0.3-1.10.3-0.5-0.80.1-0.5-0.80.90.2
Locomotor activity0.30.41.80.50.5-0.5-0.1-0.30.30.6-0.40.2-1.11.30.8
Locomotor testing distance0.10.20.80.1-0.10.1-0.20.60.40.50.90.50.2-0.1-0.7
Locomotor testing rearing0.41.43.6-1.5-1.91.9-1.5-0.1-0.7-0.41.4-0.50.0-0.0-1.2
Locomotion in novel chamber1.62.16.30.40.1-0.41.22.11.11.40.61.22.0-1.9-2.5
Locomotion in novel chamber post-restriction0.82.45.1-2.2-2.12.3-0.50.5-0.10.52.10.31.6-1.7-1.9
Fecal boli incidents, locomotor time 10.61.63.9-1.0-1.30.8-2.0-1.0-1.2-1.90.2-1.1-1.41.40.5
Change in fecal boli incidents, locomotor task1.71.84.71.31.4-1.62.21.50.91.6-1.50.61.0-0.9-0.7
Time >=10cm from walls, locomotor time 10.80.94.0-0.70.10.5-0.5-1.9-0.3-0.3-0.0-0.3-1.21.12.0
Bouts of movement, locomotor time 10.20.31.4-0.4-0.70.3-0.9-0.1-0.5-1.20.2-0.5-0.30.3-0.0
Total resting periods, locomotor time 10.30.31.4-0.4-0.60.2-0.8-0.2-0.6-1.20.1-0.6-0.30.3-0.1
Rest time, locomotor task time 10.50.81.8-0.3-0.40.1-0.9-0.8-1.2-1.1-1.0-1.4-1.11.0-0.1
Distance moved, locomotor task time 10.92.55.00.10.40.11.41.61.71.81.72.02.2-2.2-1.5
Vertical activity count, locomotor time 10.21.63.90.20.50.21.21.01.71.81.52.01.5-1.5-0.3
Time >=10cm from walls, locomotor time 20.30.73.20.40.8-0.3-0.0-1.2-0.1-0.3-0.6-0.2-1.21.21.8
Bouts of movement, locomotor time 20.10.41.1-0.8-0.31.0-0.3-1.0-0.7-0.30.7-0.60.2-0.5-0.7
Total resting periods, locomotor time 20.10.20.9-0.4-0.10.7-0.3-0.9-0.7-0.50.3-0.60.1-0.3-0.4
Rest time, locomotor task time 20.30.51.40.80.4-1.0-0.10.20.1-0.8-1.2-0.2-0.70.80.7
Distance moved, locomotor task time 21.01.44.2-1.3-0.61.40.3-0.00.51.02.00.91.5-1.6-1.0
Vertical activity count, locomotor time 20.51.13.3-1.4-0.81.7-0.0-0.20.71.01.81.10.7-0.80.1
Light reinforcement 10.31.33.2-0.7-0.70.8-1.1-1.2-0.8-0.6-1.0-1.0-1.71.81.4
Light reinforcement 20.10.10.60.50.4-0.10.20.3-0.20.3-0.8-0.2-0.30.3-0.2
Bone: marrow area0.61.54.22.02.0-1.61.41.01.01.3-0.70.90.4-0.3-0.5
Bone: maximum diameter1.53.06.12.52.4-2.12.31.71.81.6-0.91.51.1-1.0-1.0
Bone: maximum force2.85.610.82.73.2-2.43.32.02.72.9-0.72.61.6-1.4-1.1
Bone: maximum moment2.64.99.42.52.9-2.13.12.02.52.9-0.62.51.5-1.4-1.2
Mean time between licks in bursts0.21.32.9-1.7-1.51.1-1.5-0.9-0.90.21.5-0.5-1.01.00.9
Mean num. licks in bursts1.23.28.12.52.8-2.81.4-0.10.81.5-2.10.3-1.41.61.4
Cd content in liver0.50.62.1-1.3-1.01.0-0.3-0.4-0.10.51.50.20.4-0.5-0.3
Co content in liver1.92.34.51.71.7-1.32.11.31.91.9-0.81.70.9-0.8-1.3
Cu content in liver1.51.85.01.31.8-1.42.20.81.11.4-0.81.01.2-1.2-0.8
Fe content in liver1.11.33.2-0.7-1.10.90.11.20.60.81.61.01.4-1.3-1.8
K content in liver2.52.55.82.12.4-2.12.40.90.71.5-2.30.40.5-0.5-0.2
Mg content in liver1.21.34.31.91.7-1.60.9-0.0-0.30.1-2.1-0.6-0.80.90.3
Mn content in liver0.30.41.20.80.8-1.10.40.80.50.5-0.10.30.3-0.2-0.9
Na content in liver2.73.18.32.82.9-2.91.80.30.70.4-2.40.2-0.60.81.3
Rb content in liver1.61.93.9-0.4-0.50.50.91.51.21.91.41.51.8-1.7-2.0
Se content in liver0.30.42.2-0.2-0.00.10.40.50.30.40.20.50.8-0.8-1.5
Sr content in liver0.40.30.60.30.3-0.70.40.70.80.10.50.70.6-0.6-0.7
Zn content in liver0.70.82.61.31.6-1.41.2-0.20.70.1-0.70.60.3-0.30.5
Bone: minimum diameter0.91.74.21.92.1-1.51.71.11.21.2-0.21.10.8-0.8-1.0
Time in familiar zone, hab. session 11.92.15.2-0.7-0.81.20.71.81.00.21.41.52.2-2.3-1.8
Time in novel zone, hab. session 14.04.511.10.91.0-1.6-1.2-2.7-1.4-0.9-2.1-1.9-3.33.32.8
Total zone transitions, hab. session 11.21.72.91.41.4-1.51.71.61.71.5-0.91.30.8-0.6-0.4
Total locomotion distance, hab. session 11.82.54.52.02.1-2.11.81.12.11.3-1.41.40.20.01.6
Locomotion velocity, hab. session 11.52.14.41.71.7-1.71.71.22.11.4-1.11.40.3-0.11.5
Time in familiar zone, hab. session 21.92.14.90.10.30.11.31.61.31.21.41.82.2-2.2-1.8
Time in novel zone, hab. session 21.21.32.8-0.3-0.50.1-1.3-1.3-0.8-1.0-0.7-1.2-1.61.71.7
Total zone transitions, hab. session 20.60.81.91.21.2-1.30.90.80.71.4-1.00.3-0.20.4-0.4
Total locomotion distance, hab. session 20.60.81.71.21.3-1.21.00.50.90.8-0.80.4-0.20.31.0
Locomotion velocity, hab. session 20.91.22.81.51.7-1.51.30.51.21.0-1.10.6-0.20.41.2
Novel to familiar place preference ratio0.70.93.0-1.6-1.31.7-1.1-0.9-0.30.31.0-0.0-0.50.50.7
Novelty place preference0.70.93.2-1.7-1.41.8-0.9-0.7-0.20.41.10.2-0.30.20.4
Time in novel zone, NPP test0.91.13.8-1.9-1.51.9-1.0-0.7-0.10.41.40.2-0.10.10.4
Total zone transitions, NPP test0.91.33.31.71.7-1.81.41.00.60.9-1.50.10.3-0.2-0.4
Total locomotion distance, NPP test0.50.72.01.31.2-1.40.70.60.5-0.0-1.00.00.00.11.1
Locomotion velocity, NPP test0.81.13.01.71.5-1.70.90.70.4-0.0-1.6-0.2-0.20.31.1
Intraocular pressure0.50.81.6-1.3-1.10.8-0.8-0.9-1.20.30.4-1.1-0.70.7-1.0
Delta distance traveled before/after self-admin0.10.10.5-0.6-0.10.6-0.1-0.7-0.10.20.4-0.1-0.10.00.2
Delta ambulatory time before/after self-admin0.10.20.5-0.7-0.10.7-0.0-0.70.10.50.70.20.1-0.10.2
Parametrial fat weight4.09.419.53.22.8-2.63.84.43.62.9-0.73.23.2-3.0-1.5
Pavlov. Cond. lever latency0.60.82.6-1.4-1.51.6-0.60.10.20.21.10.30.4-0.4-0.4
Pavlov. Cond. magazine entry latency1.21.53.71.91.4-1.8-0.2-0.60.1-0.8-1.0-0.3-1.31.41.9
Pavlov. Cond. change in total contacts1.61.72.51.21.2-1.5-0.2-1.4-1.2-1.0-1.6-1.5-1.51.51.2
Pavlov. Cond. index score0.60.82.31.41.2-1.50.1-0.4-0.2-0.7-0.8-0.4-0.70.71.0
Pavlov. Cond. latency score0.70.93.21.71.5-1.80.4-0.0-0.0-0.4-1.0-0.3-0.50.60.7
Pavlov. Cond. lever contacts1.01.13.61.71.8-1.90.6-0.3-0.3-0.2-1.3-0.5-0.70.70.8
Pavlov. Cond. magazine entry number0.81.02.4-1.0-0.71.20.80.90.51.00.30.61.2-1.3-1.5
Pavlov. Cond. intertrial magazine entries1.01.23.7-0.9-1.01.50.21.0-0.10.91.20.31.3-1.4-1.9
Pavlov. Cond. lever-magazine prob. diff.0.60.72.21.31.2-1.50.1-0.4-0.1-0.6-0.7-0.3-0.60.71.1
Pavlov. Cond. response bias1.01.22.51.10.9-1.3-0.6-1.1-0.7-1.1-0.7-1.0-1.41.41.6
Pavlov. Cond. lever latency0.81.22.0-0.9-1.01.0-1.3-1.0-1.4-1.40.2-1.2-1.11.10.8
Pavlov. Cond. magazine entry latency0.91.33.4-1.1-1.51.1-1.8-1.0-1.2-1.30.7-1.1-0.80.80.3
Pavlov. Cond. change in total contacts0.30.81.90.0-0.20.30.41.01.11.40.61.11.0-0.9-1.3
Pavlov. Cond. index score0.10.20.4-0.2-0.50.3-0.20.30.50.30.60.50.5-0.6-0.6
Pavlov. Cond. latency score0.10.10.30.1-0.30.0-0.20.40.40.10.40.30.4-0.4-0.5
Pavlov. Cond. lever contacts0.91.32.21.11.0-1.11.31.11.51.5-0.51.31.0-0.9-0.7
Pavlov. Cond. magazine entry number0.91.13.21.61.8-1.61.30.80.80.8-0.90.70.00.10.4
Pavlov. Cond. intertrial magazine entries1.22.66.52.42.5-2.61.70.91.51.4-1.21.20.00.11.0
Pavlov. Cond. lever-magazine prob. diff.0.10.20.5-0.3-0.60.4-0.50.00.10.10.70.20.2-0.3-0.5
Pavlov. Cond. response bias0.20.30.9-0.4-0.40.30.20.20.60.70.40.60.9-0.9-0.6
Time in closed arm before self-admin0.50.92.3-1.1-1.51.1-1.20.1-0.2-1.21.50.20.4-0.5-0.3
Time in closed arm after self-admin2.63.09.0-1.5-2.01.7-2.2-1.6-2.1-3.0-0.1-2.1-1.00.80.5
Time in open arm before self-admin0.81.03.60.80.7-0.80.2-0.6-1.1-0.0-1.9-1.4-1.21.30.2
Time in open arm after self-admin3.94.311.81.82.4-2.12.71.92.33.40.22.31.4-1.2-1.3
Bone: periosteal estimation2.04.89.73.03.1-2.52.92.11.92.1-0.91.71.6-1.5-1.8
Bone: periosteal perimeter0.81.64.92.22.1-2.01.30.80.80.6-1.40.40.10.1-0.4
Bone: post-yield work2.33.99.03.03.0-2.82.41.62.01.4-1.61.80.7-0.60.5
Progressive ratio test 1 active lever presses0.10.21.6-0.1-0.10.50.10.30.11.30.60.20.2-0.1-0.4
Progressive ratio test 1 breakpoint0.10.21.6-0.2-0.30.60.10.30.11.20.70.30.2-0.2-0.4
Progressive ratio test 1 inactive lever presses0.00.10.2-0.00.20.00.0-0.30.10.40.50.2-0.10.10.4
Progressive ratio test 2 active lever presses0.71.02.0-1.2-1.41.4-1.3-0.6-1.3-0.21.1-1.0-0.30.3-1.0
Progressive ratio test 2 breakpoint0.70.91.6-1.0-1.21.3-1.2-0.5-1.2-0.11.0-0.9-0.30.3-1.0
Progressive ratio test 2 inactive lever presses0.20.51.40.20.0-0.1-0.7-0.9-1.2-0.5-0.3-1.2-1.01.0-0.0
Incentive Sensitization - Responses0.30.92.0-0.7-0.80.6-1.3-1.1-1.4-0.80.6-1.2-1.00.9-0.4
Incentive Sensitization - Breakpoint0.30.61.5-0.5-0.50.3-1.1-0.9-1.2-0.60.5-1.0-0.90.9-0.4
Sum of active levers in priming session hrs 5-61.41.33.71.51.6-1.50.7-0.2-0.50.3-1.9-0.9-1.21.30.4
Progressive ratio0.20.51.20.70.3-0.9-0.40.1-0.1-0.8-0.8-0.3-1.01.10.7
Food seeking constrained by brief footshock0.10.10.20.1-0.2-0.0-0.20.50.20.40.50.30.00.1-0.5
Seeking ratio, punishment vs. effort0.10.10.70.10.5-0.10.5-0.20.30.9-0.10.20.2-0.20.1
Retroperitoneal fat weight0.73.212.52.61.2-1.81.53.52.21.1-0.91.81.2-0.80.2
Reaction time number correct0.41.22.2-1.5-1.41.2-1.5-1.3-1.2-0.80.6-1.1-0.90.80.3
Reaction time mean minus median0.00.10.20.40.3-0.40.20.20.40.10.40.40.1-0.00.2
Reaction time mean minus median AUC0.00.00.2-0.3-0.30.2-0.1-0.1-0.00.20.50.1-0.10.1-0.0
Reaction time num false alarms0.10.20.9-1.0-0.60.6-0.10.10.00.20.40.10.4-0.5-0.5
Reaction time num false alarms AUC0.00.00.3-0.3-0.0-0.20.20.1-0.0-0.1-0.6-0.10.1-0.1-0.1
Reaction time trials correct on left0.41.22.2-1.5-1.41.2-1.5-1.3-1.2-0.80.6-1.1-0.90.80.3
Reaction time trials on left0.41.22.2-1.4-1.41.2-1.5-1.3-1.2-0.80.6-1.1-1.00.90.3
Reaction time mean0.30.62.20.70.6-0.8-0.1-0.30.0-0.2-0.7-0.2-1.21.31.5
Reaction time mean AUC0.30.82.40.60.5-0.7-0.3-0.6-0.5-0.4-0.9-0.7-1.41.61.5
Median of all reaction times0.50.82.70.70.6-0.8-0.2-0.5-0.1-0.2-1.0-0.4-1.41.61.6
Reaction time omissions0.81.22.80.50.6-1.2-0.6-1.1-0.8-1.0-1.4-1.0-1.61.71.2
Reaction time false alarm rate0.20.20.40.10.4-0.40.60.60.40.3-0.40.40.6-0.6-0.5
Reaction time premature initiation rate1.72.75.90.30.8-1.3-0.8-2.2-0.8-1.6-1.7-1.3-2.42.42.3
Reaction time premature initiations1.44.39.3-0.40.1-0.7-1.6-3.0-1.7-2.2-1.6-2.1-3.03.02.6
Std. dev. reaction times0.00.20.40.60.3-0.6-0.10.2-0.0-0.4-0.1-0.1-0.40.50.6
Reaction time trials completed0.41.22.2-1.4-1.41.2-1.5-1.3-1.2-0.80.6-1.1-1.00.90.3
Reaction time trials AUC0.31.01.9-1.3-1.21.1-1.4-1.2-1.1-0.70.5-1.0-0.90.80.3
Run reversals in cocaine runway, females1.41.65.42.02.0-2.30.9-0.20.40.1-1.6-0.1-0.80.90.9
Run reversals in cocaine runway, males0.20.20.90.00.5-0.30.2-0.9-0.5-0.2-0.8-0.6-0.50.40.2
Latency to leave start box in cocaine runway1.31.84.20.60.5-0.41.82.01.51.1-0.11.41.9-1.9-1.2
Latency to leave start box in cocaine runway, F0.40.61.7-0.5-0.70.70.20.7-0.0-0.40.70.11.2-1.3-1.0
Latency to leave start box in cocaine runway, M2.52.44.91.41.4-1.32.22.02.01.7-1.11.71.3-1.1-0.3
Std. dev. time between licks in bursts0.10.31.7-0.4-0.50.3-0.20.40.10.81.30.50.3-0.2-0.3
Total sessions with >9 infusions0.30.41.80.70.9-0.60.40.10.61.30.30.6-0.10.20.2
Short access day 1 total inactive lever presses0.91.83.90.90.9-1.2-0.6-1.6-1.2-1.0-1.5-1.4-2.02.01.3
Short access day 10 total inactive lever presses0.10.51.4-1.1-0.70.8-0.7-1.2-0.6-0.90.5-0.4-0.30.20.6
Short access day 1 total infusions1.12.14.6-0.6-0.50.3-1.5-2.1-1.6-0.6-0.2-1.6-2.12.11.7
Short access day 10 total infusions0.10.21.1-0.3-0.20.5-0.4-0.3-0.00.41.10.10.0-0.0-0.1
Short access total infusions0.10.20.60.30.5-0.3-0.0-0.40.10.80.20.0-0.50.60.6
Short access day 1 locomotion0.61.13.4-1.1-0.61.0-1.0-1.8-1.4-0.40.2-1.3-1.00.90.5
Short access day 10 total locomotion0.20.92.1-0.30.20.30.70.61.10.91.31.51.3-1.4-0.6
Short access total locomotion0.60.92.40.40.5-0.21.01.11.11.60.71.21.1-1.0-0.9
One hour access (0.3 mA shock)0.81.03.3-0.4-0.80.9-0.31.20.60.91.81.01.0-0.9-1.1
Compulsive drug intake0.40.61.41.11.2-0.90.90.40.70.5-1.20.4-0.20.31.0
One hour access (shock baseline)0.41.13.4-1.0-1.11.1-0.30.90.30.81.80.71.1-1.1-1.6
Social response proportion0.50.61.7-0.8-1.00.8-1.3-0.6-0.5-0.80.9-0.3-0.60.60.5
Social responses0.40.51.3-0.5-0.90.7-1.2-0.2-0.7-1.00.8-0.6-0.40.5-0.2
Social time0.50.72.1-1.2-1.51.4-1.10.1-0.5-0.31.2-0.1-0.20.3-0.3
Soleus weight2.16.312.83.63.1-2.93.03.12.72.4-0.82.11.8-1.6-1.2
Bone: stiffness4.17.413.73.13.3-2.73.72.73.22.8-1.03.02.2-2.1-1.7
Tibialis anterior weight4.214.433.65.45.8-5.84.73.03.83.6-2.33.21.1-0.60.2
Time to tail flick, vehicle, before self-admin0.50.61.61.30.9-1.20.81.00.50.8-0.60.40.2-0.1-0.7
Time to tail flick, vehicle, after self-admin0.10.10.40.3-0.30.4-0.20.5-0.4-0.4-0.4-0.4-0.00.1-0.7
Time to tail flick, test, before self-admin0.80.93.01.71.6-1.70.60.30.80.2-0.40.6-0.30.40.6
Time to tail flick, test, after self-admin0.90.92.7-0.8-1.00.9-0.60.50.3-1.01.60.61.2-1.4-0.5
Delta time to tail flick, vehicle, before/after SA0.10.10.2-0.0-0.10.40.30.30.20.0-0.00.10.4-0.5-0.2
Delta time to tail flick, test, before/after SA0.60.71.5-0.9-1.00.9-0.30.60.6-0.31.20.81.1-1.2-0.4
Tibia length0.10.20.40.50.3-0.20.50.60.60.60.30.60.4-0.4-0.4
Ambulatory time before self-admin0.20.51.4-1.2-0.80.9-0.4-0.7-1.0-0.20.0-1.0-0.30.2-0.3
Ambulatory time after self-admin0.61.02.9-1.6-0.71.0-0.7-1.7-1.20.10.4-1.1-0.90.80.1
Bone: tissue strength0.50.51.40.50.9-0.90.6-0.5-0.20.5-1.2-0.4-0.80.81.1
Total heroin consumption0.30.41.60.40.2-0.40.00.6-0.51.30.3-0.5-0.40.5-1.1
Bone: trabecular number0.30.61.20.40.6-0.31.00.90.91.10.30.90.8-0.7-0.8
Bone: trabecular spacing1.21.73.5-0.0-0.2-0.1-1.2-1.4-1.5-1.5-0.8-1.6-1.91.81.6
Bone: trabecular thickness1.72.44.21.00.7-0.51.32.12.02.00.82.11.8-1.7-1.5
Bone: trabecular tissue density0.40.72.61.61.1-1.10.80.8-0.10.0-1.2-0.3-0.30.4-0.3
Water consumed over 24 hours0.51.02.6-1.0-0.70.6-1.1-1.6-1.3-1.40.1-1.2-0.60.4-0.5
Number of responses in last shaping day0.60.82.4-0.1-0.1-0.1-0.8-1.1-0.9-0.2-0.3-0.9-1.51.61.3