Hub : Genes

Map4k2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose gene expression Map4k2 0.42 0.11 0.0e+00 0.32 0.32 0.32 0.32 2.8e-36 9.3e-36 7.8e-36 7.4e-36
2 Eye isoform ratio NM_001415830.1 0.38 0.17 3.3e-03 0.05 0.08 0.15 0.04 5.5e-02 2.3e-02 2.5e-03 7.1e-02
3 pVTA gene expression Map4k2 0.23 0.1 5.9e-12 0.04 0.11 0.12 0.13 1.7e-04 6.3e-09 8.4e-10 2.5e-10
4 NAcc gene expression Map4k2 0.19 0.07 0.0e+00 0.12 0.15 0.16 0.16 6.1e-17 2.1e-22 5.6e-23 5.1e-23
5 IC gene expression Map4k2 0.26 0.11 7.5e-08 0.04 0.11 0.1 0.13 8.1e-03 2.2e-05 5.0e-05 3.5e-06
6 BLA gene expression Map4k2 0.26 0.11 2.7e-07 0.1 0.12 0.1 0.1 3.5e-06 8.3e-07 5.1e-06 3.5e-06
7 Brain gene expression Map4k2 0.32 0.12 0.0e+00 0.19 0.22 0.19 0.22 1.4e-17 1.7e-20 2.5e-17 5.5e-20
8 PL gene expression Map4k2 0.31 0.14 5.6e-17 0.16 0.16 0.14 0.15 8.1e-17 1.4e-17 6.3e-15 6.5e-16
9 OFC gene expression Map4k2 0.57 0.22 1.6e-04 0.19 0.23 0.2 0.2 2.7e-05 4.1e-06 2.2e-05 2.0e-05
10 LHb gene expression Map4k2 0.22 0.13 4.9e-03 0 -0.01 -0.01 -0.01 2.5e-01 5.9e-01 9.5e-01 5.5e-01
11 Liver gene expression Map4k2 0.26 0.13 2.5e-10 0.07 0.08 0.07 0.08 6.1e-08 8.2e-09 2.7e-08 2.5e-09
12 NAcc intron excision ratio chr1_213074576_213074698 0.02 0.02 5.4e-03 0.01 0.01 0.01 0.01 1.2e-02 3.6e-02 2.0e-02 3.1e-02
13 NAcc intron excision ratio chr1_213074755_213074979 0.02 0.02 6.5e-03 0.01 0 0.01 0 1.0e-02 6.9e-02 3.8e-02 4.5e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13
Bone: apparent density0.50.93.90.9-0.4-0.7-0.7-0.6-0.5-0.6-0.5-0.40.4-0.4-2.02.0
Area under the delay curve0.30.40.7-0.1-0.10.50.50.60.50.80.80.7-0.70.7-0.80.8
BMI with tail1.34.621.32.3-1.8-1.3-1.6-1.1-0.9-1.0-0.6-0.40.3-0.3-4.64.6
BMI without tail0.31.56.51.5-0.4-0.2-0.00.30.30.60.80.9-0.90.9-2.52.5
Body weight1.14.918.23.70.8-2.2-1.8-1.2-1.0-0.9-0.7-0.80.0-0.1-4.34.3
Weight adjusted by age0.41.22.61.51.2-1.6-1.4-1.2-1.1-0.9-1.0-1.20.8-0.8-0.20.2
Bone surface3.67.010.43.10.6-3.2-3.1-2.8-2.6-2.6-2.6-2.62.1-2.1-2.92.9
Bone volume2.24.56.01.8-0.2-2.3-2.4-2.3-2.2-2.3-2.2-2.12.0-2.0-2.32.3
Breakpoint value in progressive ratio session1.22.14.22.01.2-2.0-1.9-1.6-1.6-1.1-1.3-1.41.0-1.1-1.11.1
Number of licking bursts0.10.30.60.60.1-0.8-0.7-0.7-0.7-0.6-0.6-0.60.5-0.5-0.00.0
Context. condit. distance diff. score1.11.32.8-1.6-1.01.71.41.21.31.21.11.0-0.90.9-0.00.0
Locomotion velocity, session 10.60.71.10.10.60.60.91.01.00.90.90.8-1.01.0-0.80.8
Locomotion distance, session 10.60.83.30.80.10.10.50.60.50.40.60.8-0.70.8-1.81.8
Locomotion velocity, session 20.70.93.71.90.9-1.2-0.8-0.5-0.5-0.3-0.3-0.2-0.00.0-1.41.4
Locomotion distance, session 20.40.61.51.00.30.00.40.60.50.50.81.0-0.80.9-1.21.2
Locomotion velocity, session 31.11.24.0-0.4-1.31.01.00.91.00.40.70.9-0.70.7-2.02.0
Locomotion distance, session 30.10.10.2-0.2-0.30.40.30.40.40.30.30.3-0.30.3-0.50.5
Stereotopy head waving bouts, day 31.61.93.5-0.9-1.61.51.41.31.50.81.21.4-1.11.1-1.91.9
Stereotopy head waving duration, day 30.40.51.8-0.9-1.30.90.80.60.70.20.50.7-0.30.4-0.70.7
Locomotion velocity, session 70.60.73.1-0.6-1.80.70.60.40.50.10.50.7-0.20.3-1.21.2
Locomotion distance, session 70.91.22.1-0.2-0.51.01.21.21.21.11.31.4-1.21.2-1.01.0
Stereotopy head waving bouts, day 70.80.91.4-0.1-1.2-0.6-1.0-1.1-1.0-1.1-1.0-1.01.1-1.1-0.60.6
Stereotopy head waving duration, day 71.21.52.41.0-0.3-1.4-1.6-1.5-1.5-1.3-1.3-1.31.3-1.3-0.60.6
Locomotion velocity, session 80.60.71.81.01.30.00.40.70.70.80.60.5-1.11.0-1.11.1
Locomotion distance, session 80.50.72.4-0.5-1.30.80.60.60.70.30.40.5-0.40.5-1.51.5
Degree of sensitization distance0.50.61.40.0-0.80.60.60.60.70.40.70.9-0.60.6-1.21.2
Degree of sensitization stereotypy1.61.82.80.7-0.5-1.5-1.7-1.7-1.7-1.6-1.5-1.61.5-1.5-0.50.5
Conditioned locomotion0.30.32.01.40.6-0.8-0.5-0.3-0.3-0.2-0.1-0.1-0.10.1-0.70.7
Cocaine response after cond. corrected1.52.23.6-1.4-1.01.91.81.81.81.51.71.7-1.51.5-0.20.2
Cocaine response after cond. not corrected1.01.52.6-1.1-0.81.61.51.41.61.21.41.3-1.21.2-0.40.4
Cocaine response before conditioning1.11.32.11.10.9-1.4-1.5-1.4-1.4-1.1-1.3-1.31.1-1.1-0.00.0
Saline control response0.91.36.72.62.1-1.4-0.8-0.3-0.30.10.0-0.2-0.50.4-1.11.1
Bone: connectivity density1.32.05.32.00.5-1.6-1.5-1.2-1.2-1.0-1.0-1.00.7-0.7-2.32.3
Bone: cortical apparent density0.20.41.70.30.9-0.3-0.1-0.0-0.30.30.20.1-0.10.11.3-1.3
Bone: cortical area0.61.01.51.10.3-1.2-1.2-1.1-1.0-1.1-1.1-1.10.9-0.9-0.60.6
Bone: cortical porosity0.00.00.20.5-0.0-0.3-0.3-0.2-0.3-0.2-0.00.10.1-0.10.0-0.0
Bone: cortical porosity0.10.10.80.90.4-0.5-0.4-0.3-0.3-0.1-0.00.00.0-0.0-0.30.3
Bone: cortical thickness0.71.26.92.32.6-1.3-0.6-0.2-0.40.30.0-0.2-0.50.40.5-0.5
Bone: cortical thickness1.01.32.70.71.70.51.01.21.01.41.31.1-1.51.5-0.20.2
Bone: cortical tissue density0.30.41.80.51.1-0.4-0.1-0.0-0.30.30.20.1-0.10.11.3-1.3
Condit. Reinf. active minus inactive responses0.00.10.10.30.3-0.20.00.10.00.30.30.3-0.30.30.0-0.0
Condit. Reinf. active-inactive response ratio0.10.10.70.10.5-0.2-0.1-0.0-0.20.20.20.2-0.10.10.8-0.8
Condit. Reinf. active responses0.00.00.20.0-0.4-0.1-0.2-0.2-0.1-0.1-0.00.10.1-0.1-0.30.3
Condit. Reinf. inactive responses0.30.31.5-0.3-1.20.2-0.1-0.2-0.0-0.5-0.3-0.20.4-0.4-1.01.0
Incentive salience index mean0.10.10.50.5-0.1-0.2-0.10.00.00.20.30.3-0.20.2-0.70.7
Condit. Reinf. lever presses0.40.61.40.7-0.6-0.8-0.9-0.8-0.7-0.8-0.7-0.60.6-0.6-1.21.2
Condit. Reinf. active minus inactive responses0.40.61.2-0.2-0.7-0.5-0.8-0.9-0.9-1.1-1.0-0.91.1-1.1-0.10.1
Condit. Reinf. active-inactive response ratio0.91.43.2-0.8-1.8-0.3-0.9-1.2-0.9-1.6-1.4-1.31.6-1.5-0.50.5
Condit. Reinf. active responses0.30.50.90.4-0.3-0.7-0.9-0.9-1.0-0.8-0.8-0.70.8-0.8-0.00.0
Condit. Reinf. inactive responses0.20.30.70.90.8-0.20.10.30.00.70.60.5-0.60.60.2-0.2
Condit. Reinf. lever presses2.33.34.81.80.1-2.2-2.2-2.1-2.1-2.0-2.0-2.01.7-1.7-1.31.3
Condit. Reinf. lever reinforcers received0.60.81.50.80.1-1.1-1.1-1.1-1.2-1.0-1.0-1.01.0-1.0-0.00.0
Conditioned reinforcement - actives1.03.86.60.0-0.6-1.6-2.1-2.4-2.0-2.5-2.5-2.52.6-2.60.1-0.1
Conditioned reinforcement - inactives0.92.44.4-2.1-1.9-0.0-0.9-1.3-1.0-1.6-1.7-1.72.1-2.01.1-1.1
Conditioned locomotion1.82.710.8-3.3-2.91.70.60.10.1-0.6-0.6-0.41.1-1.02.3-2.3
Patch foraging indifference point 0 sec0.00.00.1-0.20.10.00.10.00.00.00.10.2-0.00.00.4-0.4
Patch foraging indifference point AUC1.33.16.12.01.6-2.5-2.2-2.0-2.0-1.6-1.8-2.01.5-1.6-0.10.1
Delay disc. indifference point, 0s delay1.01.12.9-0.4-0.41.11.00.81.01.11.01.0-0.90.9-1.71.7
Delay disc. indifference point, 16s delay0.10.20.9-1.0-0.80.40.10.1-0.1-0.0-0.10.00.2-0.10.5-0.5
Delay disc. indifference point, 2s delay0.20.21.2-0.4-0.60.2-0.1-0.10.0-0.0-0.1-0.20.1-0.1-1.11.1
Delay disc. indifference point, 24s delay0.40.71.2-0.20.60.70.81.00.81.11.00.9-1.11.00.6-0.6
Delay disc. indifference point, 4s delay1.21.22.3-0.3-0.21.11.01.21.21.51.41.3-1.31.3-0.80.8
Delay disc. indifference point, 8s delay0.50.81.5-0.00.10.80.91.00.91.21.21.1-1.11.1-0.60.6
Indifference point function ln k2.98.717.5-3.7-2.34.23.73.33.42.82.93.1-2.42.50.7-0.7
Indifference point function log k2.98.717.5-3.7-2.34.23.73.33.42.82.93.1-2.42.50.7-0.7
Patch foraging total patch changes 0 sec0.10.20.4-0.10.60.30.40.50.40.50.50.5-0.50.50.6-0.6
Patch foraging total patch changes 12 sec1.62.27.02.62.2-2.2-1.7-1.4-1.5-0.9-1.0-1.10.6-0.7-0.80.8
Patch foraging total patch changes 18 sec0.40.81.71.00.9-1.3-1.2-1.1-1.0-0.8-0.9-1.00.8-0.8-0.10.1
Patch foraging total patch changes 24 sec0.31.03.11.81.8-1.6-1.1-0.9-0.9-0.6-0.7-0.90.3-0.4-0.10.1
Patch foraging total patch changes 6 sec0.20.41.51.21.0-0.5-0.10.00.00.20.20.2-0.50.4-0.80.8
Patch foraging time to switch 0 sec0.62.44.51.8-0.4-1.6-1.7-1.6-1.5-1.5-1.3-1.21.2-1.2-2.12.1
Patch foraging water rate 0 sec0.83.07.2-2.7-0.62.01.91.61.71.31.21.0-0.90.92.5-2.5
Patch foraging water rate 12 sec2.28.914.5-3.8-1.13.83.73.33.42.82.72.7-2.42.42.8-2.8
Patch foraging water rate 18 sec1.94.27.0-2.2-1.22.62.62.52.52.02.12.1-1.91.91.1-1.1
Patch foraging water rate 24 sec2.33.36.5-2.6-1.22.42.22.02.21.71.61.5-1.41.41.5-1.5
Patch foraging water rate 6 sec4.36.410.4-2.5-0.33.13.23.03.12.72.62.5-2.42.41.7-1.7
Seeking ratio, delayed vs. immediate footshock0.20.20.7-0.5-0.60.50.40.50.30.50.70.8-0.30.40.1-0.1
Distance traveled before self-admin0.91.93.00.9-0.0-1.6-1.7-1.7-1.6-1.5-1.5-1.61.5-1.5-0.90.9
Distance traveled after self-admin0.30.50.80.50.5-0.9-0.8-0.7-0.9-0.6-0.6-0.60.7-0.70.7-0.7
Extensor digitorum longus weight2.18.434.75.93.4-4.0-3.1-2.1-2.2-1.4-1.3-1.50.4-0.6-3.33.3
Bone: elastic displacement2.02.53.6-1.00.71.71.91.91.81.81.71.6-1.71.71.4-1.4
Bone: elastic work1.11.42.71.01.60.40.91.21.21.51.31.2-1.61.6-0.00.0
Bone: endosteal estimation0.71.66.8-1.3-2.60.80.2-0.10.3-0.7-0.4-0.20.5-0.4-2.32.3
Bone: endosteal perimeter1.12.610.5-1.5-3.20.2-0.6-0.9-0.5-1.6-1.3-1.11.5-1.4-2.22.2
Epididymis fat weight0.52.512.3-3.4-3.51.30.3-0.30.2-1.0-1.0-0.81.4-1.30.2-0.2
Delta time in closed arm before/after self-admin3.02.85.00.31.11.31.82.01.92.02.02.0-2.22.2-0.50.5
Delta time in open arm before/after self-admin2.42.94.90.4-0.2-1.8-2.1-2.2-2.0-1.8-2.0-2.22.1-2.10.1-0.1
Diff in mean of infusions in LGA sessions0.10.21.00.81.0-0.6-0.4-0.2-0.20.0-0.2-0.3-0.10.0-0.10.1
Delay discount exponential model param0.20.30.6-0.0-0.0-0.4-0.4-0.5-0.4-0.8-0.7-0.70.6-0.70.6-0.6
Extinction: sum of active levers before priming0.71.12.71.60.6-1.4-1.3-1.1-1.1-0.7-0.7-0.70.6-0.6-1.21.2
Active lever presses in extinction session 63.53.55.82.00.9-2.4-2.4-2.2-1.9-1.9-2.1-2.21.7-1.7-1.11.1
Bone: final force1.22.04.42.10.7-1.8-1.6-1.3-1.2-1.2-1.2-1.20.8-0.8-1.81.8
Bone: final moment1.11.74.02.00.7-1.7-1.4-1.2-1.1-1.1-1.1-1.10.7-0.7-1.71.7
Food consumed during 24 hour testing period0.40.91.30.30.5-1.0-0.9-0.9-1.0-1.0-1.0-1.10.9-1.01.1-1.1
Glucose1.21.95.5-2.0-2.41.91.41.21.40.71.01.3-0.60.7-1.11.1
Heart weight2.23.65.2-1.2-1.52.32.02.02.21.81.92.1-1.81.9-1.91.9
Delay discount hyperbolic model param0.20.30.60.00.2-0.4-0.3-0.4-0.4-0.7-0.6-0.50.5-0.60.8-0.8
Intermittent access intake day 1-15 change0.31.42.5-1.3-0.8-0.2-0.8-1.1-0.8-1.2-1.3-1.41.6-1.61.2-1.2
Intermittent access intake escalation0.31.73.3-1.2-0.7-0.5-1.0-1.4-1.1-1.4-1.6-1.61.8-1.81.2-1.2
Intermittent access intake escalation 20.91.53.1-1.1-0.7-0.5-0.9-1.3-1.0-1.4-1.5-1.51.8-1.71.0-1.0
Intermitt. access day 1 inactive lever presses0.00.20.4-0.40.4-0.4-0.0-0.3-0.3-0.2-0.2-0.10.5-0.50.7-0.7
Intermitt. access day 15 inactive lever presses0.21.32.8-1.7-1.5-0.1-0.5-0.9-0.8-1.4-1.4-1.11.6-1.50.4-0.4
Intermitt. access escalation Index0.62.04.3-2.1-1.42.01.61.41.41.31.21.4-0.91.01.1-1.1
Intermittent access day 1 total infusions0.72.013.8-1.9-3.71.1-0.0-0.3-0.1-1.1-0.8-0.51.0-0.9-1.41.4
Intermittent access day 15 total infusions1.33.212.5-2.8-3.50.7-0.6-1.1-0.7-1.8-1.8-1.62.1-2.00.2-0.2
Intermittent access terminal intake (last 3 days)2.23.814.8-2.5-3.80.5-1.0-1.4-0.9-2.2-2.1-1.92.3-2.3-0.60.6
Intermittent access total infusions2.12.513.1-2.2-3.60.8-0.4-0.8-0.4-1.6-1.5-1.21.6-1.5-0.90.9
Intermittent access day 1 locomotion0.71.28.9-1.6-3.01.10.1-0.10.0-0.7-0.5-0.30.7-0.6-0.80.8
Intermittent access day 15 total locomotion1.14.114.3-2.5-3.80.3-1.2-1.7-1.3-2.2-2.3-2.12.5-2.50.2-0.2
Intermittent access total locomotion4.14.921.1-2.9-4.60.6-1.1-1.6-1.2-2.3-2.3-2.02.6-2.5-0.40.4
Intermittent access standard deviation0.10.52.1-1.4-0.90.3-0.1-0.4-0.2-0.7-0.7-0.70.9-0.90.5-0.5
Left kidney weight0.10.84.4-1.7-2.10.80.0-0.30.1-0.4-0.4-0.40.7-0.7-0.80.8
Right kidney weight0.10.41.7-1.1-1.30.4-0.0-0.20.0-0.5-0.5-0.50.5-0.5-0.20.2
Cocaine induced anxiety0.20.71.20.1-0.0-0.7-1.0-1.1-0.9-0.9-1.0-1.01.1-1.1-0.10.1
Post-drug Anxiety0.60.71.10.90.6-1.0-0.9-1.0-0.8-0.8-0.8-0.80.9-0.9-0.60.6
Baseline Anxiety0.40.71.20.70.90.40.90.90.81.01.01.0-1.11.1-0.20.2
Tail length0.20.95.81.42.4-0.50.20.50.40.90.80.5-1.00.90.2-0.2
Length with tail0.52.210.03.03.2-1.7-0.7-0.2-0.30.20.1-0.2-0.80.6-1.51.5
Length without tail0.31.88.52.62.9-1.3-0.30.20.10.30.20.0-1.11.0-1.31.3
Times rat made contact with spout0.30.31.40.71.2-0.20.20.40.20.70.60.6-0.60.60.3-0.3
Lifetime Intake1.31.610.7-1.8-3.31.0-0.0-0.4-0.0-1.0-0.9-0.61.0-0.9-1.01.0
Liver weight, left0.61.12.0-1.2-0.81.41.41.21.40.90.90.9-0.90.9-0.50.5
Liver weight, right2.34.17.8-2.1-1.02.82.62.42.72.12.02.0-1.92.0-0.60.6
Locomotor activity2.43.76.0-1.9-0.22.42.52.32.42.12.01.9-1.91.91.0-1.0
Locomotor testing distance2.25.59.0-2.2-0.12.83.02.92.92.62.52.4-2.42.40.9-0.9
Locomotor testing rearing1.24.47.4-2.10.12.62.72.52.52.42.22.1-2.12.10.8-0.8
Locomotion in novel chamber1.11.57.4-2.7-2.71.40.70.20.5-0.4-0.3-0.00.7-0.60.8-0.8
Locomotion in novel chamber post-restriction0.31.04.9-2.2-1.81.00.3-0.10.0-0.4-0.5-0.30.8-0.80.9-0.9
Fecal boli incidents, locomotor time 10.92.34.20.1-0.4-1.3-1.7-2.0-1.7-1.7-1.9-2.02.0-2.1-0.20.2
Change in fecal boli incidents, locomotor task1.81.93.5-0.1-0.31.31.61.71.71.41.71.9-1.71.7-0.30.3
Time >=10cm from walls, locomotor time 11.72.16.4-0.7-2.5-0.4-1.2-1.4-1.1-1.8-1.6-1.31.7-1.6-1.11.1
Bouts of movement, locomotor time 11.72.24.41.41.9-2.0-1.4-1.3-1.7-0.8-0.7-0.81.0-1.02.1-2.1
Total resting periods, locomotor time 11.82.13.71.11.4-1.8-1.5-1.5-1.8-1.0-0.9-1.01.2-1.31.9-1.9
Rest time, locomotor task time 10.30.51.8-1.3-1.10.50.3-0.10.1-0.3-0.2-0.10.5-0.51.1-1.1
Distance moved, locomotor task time 10.10.31.60.3-0.50.1-0.10.10.10.20.10.2-0.30.3-1.31.3
Vertical activity count, locomotor time 10.10.51.3-1.1-0.91.10.90.80.80.60.50.5-0.50.5-0.30.3
Time >=10cm from walls, locomotor time 20.61.62.60.4-0.4-1.3-1.5-1.5-1.6-1.6-1.5-1.41.6-1.60.6-0.6
Bouts of movement, locomotor time 20.10.41.00.71.0-0.8-0.6-0.6-0.8-0.2-0.2-0.20.4-0.40.6-0.6
Total resting periods, locomotor time 20.10.20.50.40.6-0.6-0.5-0.5-0.7-0.2-0.2-0.20.4-0.40.5-0.5
Rest time, locomotor task time 20.50.83.0-1.7-1.71.31.00.60.70.20.40.6-0.00.10.2-0.2
Distance moved, locomotor task time 20.30.41.71.31.1-1.0-0.7-0.4-0.6-0.2-0.3-0.40.0-0.10.1-0.1
Vertical activity count, locomotor time 20.30.81.3-0.11.00.60.91.10.91.00.90.7-1.21.10.7-0.7
Light reinforcement 10.10.20.9-0.30.90.10.40.20.10.30.10.2-0.20.21.0-1.0
Light reinforcement 20.71.73.4-1.0-0.8-0.7-0.8-1.3-1.2-1.8-1.8-1.51.8-1.80.6-0.6
Bone: marrow area0.71.67.2-1.3-2.70.90.30.10.5-0.5-0.30.00.4-0.3-2.32.3
Bone: maximum diameter1.22.33.90.5-0.6-1.4-1.7-1.7-1.4-2.0-2.0-1.91.7-1.7-1.01.0
Bone: maximum force2.24.38.22.50.1-2.4-2.3-2.0-1.9-2.0-1.9-1.81.5-1.5-2.92.9
Bone: maximum moment2.03.87.42.40.1-2.2-2.1-1.9-1.7-1.9-1.7-1.61.3-1.3-2.72.7
Mean time between licks in bursts0.31.93.20.51.40.91.31.51.51.71.71.6-1.81.80.1-0.1
Mean num. licks in bursts0.20.61.0-0.50.40.80.90.90.81.01.00.9-0.80.80.5-0.5
Cd content in liver1.11.22.2-1.2-1.4-0.2-0.8-1.1-1.0-1.1-1.3-1.31.5-1.50.7-0.7
Co content in liver2.63.04.7-1.20.81.71.91.81.62.01.81.6-1.61.62.2-2.2
Cu content in liver0.10.10.5-0.2-0.10.0-0.0-0.1-0.20.10.10.20.1-0.10.7-0.7
Fe content in liver0.20.21.00.40.2-0.20.00.10.1-0.1-0.3-0.4-0.30.3-1.01.0
K content in liver0.50.52.00.6-0.10.20.10.30.50.60.60.5-0.60.6-1.41.4
Mg content in liver0.91.01.5-0.7-0.61.21.11.11.21.21.21.2-1.01.1-0.40.4
Mn content in liver2.22.44.92.11.2-2.2-1.9-1.7-1.7-1.6-1.7-1.71.2-1.2-0.60.6
Na content in liver0.20.20.50.70.7-0.5-0.5-0.4-0.2-0.2-0.3-0.50.2-0.2-0.20.2
Rb content in liver1.92.23.9-1.6-1.22.01.91.71.71.51.61.6-1.41.40.2-0.2
Se content in liver0.70.91.9-0.4-0.8-0.7-0.8-1.0-1.0-1.2-1.4-1.31.1-1.10.2-0.2
Sr content in liver1.71.53.61.71.9-1.7-1.5-1.2-1.3-0.9-1.1-1.20.8-0.80.2-0.2
Zn content in liver0.10.10.80.50.9-0.2-0.10.1-0.10.30.10.2-0.30.30.4-0.4
Bone: minimum diameter0.61.15.7-1.2-2.40.60.1-0.10.1-0.6-0.30.00.5-0.5-1.71.7
Time in familiar zone, hab. session 10.20.21.4-0.5-1.20.60.30.20.30.20.20.3-0.10.1-0.20.2
Time in novel zone, hab. session 10.70.81.3-0.40.80.91.11.21.11.11.00.9-1.11.10.2-0.2
Total zone transitions, hab. session 10.20.31.01.00.3-0.8-0.5-0.4-0.6-0.4-0.3-0.20.2-0.2-0.40.4
Total locomotion distance, hab. session 10.20.32.0-0.5-1.40.50.40.30.3-0.10.10.4-0.00.1-0.80.8
Locomotion velocity, hab. session 10.10.10.8-0.1-0.90.10.10.00.0-0.2-0.00.20.1-0.0-0.60.6
Time in familiar zone, hab. session 21.41.52.8-0.30.61.31.31.41.61.71.41.2-1.61.60.1-0.1
Time in novel zone, hab. session 20.40.51.00.4-0.1-0.9-0.8-0.8-1.0-0.9-0.7-0.50.8-0.8-0.20.2
Total zone transitions, hab. session 20.60.73.41.4-0.1-0.6-0.3-0.1-0.2-0.10.20.4-0.20.2-1.81.8
Total locomotion distance, hab. session 20.60.82.20.0-1.10.70.60.70.70.50.71.0-0.60.7-1.51.5
Locomotion velocity, hab. session 20.50.62.5-0.2-1.60.60.40.40.50.10.40.7-0.20.3-1.41.4
Novel to familiar place preference ratio2.43.25.11.2-0.0-2.1-2.3-2.2-2.2-2.0-2.0-2.12.0-2.0-0.40.4
Novelty place preference1.82.33.70.8-0.1-1.7-1.9-1.9-1.9-1.7-1.7-1.81.7-1.7-0.20.2
Time in novel zone, NPP test1.31.62.60.7-0.1-1.5-1.6-1.6-1.6-1.4-1.4-1.51.4-1.4-0.30.3
Total zone transitions, NPP test0.81.23.92.00.7-1.5-1.1-0.8-0.9-0.7-0.6-0.50.3-0.4-1.61.6
Total locomotion distance, NPP test0.30.41.70.3-0.70.20.30.40.30.20.40.6-0.40.4-1.31.3
Locomotion velocity, NPP test0.10.20.90.4-0.6-0.10.10.10.0-0.10.20.4-0.10.1-0.90.9
Intraocular pressure1.42.25.4-1.2-0.6-0.5-1.1-1.4-1.1-1.3-1.4-1.51.7-1.72.3-2.3
Delta distance traveled before/after self-admin1.51.72.4-0.40.51.11.51.61.31.51.51.5-1.51.51.2-1.2
Delta ambulatory time before/after self-admin0.81.42.2-0.20.51.01.41.51.31.41.51.4-1.51.50.7-0.7
Parametrial fat weight0.81.810.1-2.9-3.21.70.80.20.5-0.3-0.3-0.10.7-0.6-0.00.0
Pavlov. Cond. lever latency0.10.10.5-0.60.10.30.40.30.20.20.10.1-0.10.10.7-0.7
Pavlov. Cond. magazine entry latency0.50.60.90.6-0.5-0.8-1.0-0.9-0.9-0.7-0.7-0.60.7-0.7-1.01.0
Pavlov. Cond. change in total contacts1.31.42.50.2-0.4-1.2-1.5-1.5-1.6-1.4-1.3-1.31.5-1.5-0.10.1
Pavlov. Cond. index score0.40.50.90.50.0-0.8-1.0-0.9-0.9-0.7-0.7-0.70.7-0.7-0.10.1
Pavlov. Cond. latency score0.10.20.40.4-0.2-0.5-0.6-0.5-0.5-0.4-0.4-0.40.4-0.4-0.40.4
Pavlov. Cond. lever contacts0.10.10.50.3-0.3-0.0-0.1-0.10.00.10.10.1-0.10.1-0.70.7
Pavlov. Cond. magazine entry number0.81.01.8-0.6-0.41.21.31.31.41.01.11.1-1.11.1-0.30.3
Pavlov. Cond. intertrial magazine entries0.50.62.8-0.9-0.00.1-0.1-0.3-0.3-0.2-0.4-0.40.6-0.51.7-1.7
Pavlov. Cond. lever-magazine prob. diff.0.50.71.30.7-0.0-1.0-1.1-1.1-1.1-0.8-0.8-0.80.8-0.8-0.30.3
Pavlov. Cond. response bias0.50.61.10.50.1-0.9-1.0-1.0-1.0-0.8-0.8-0.90.8-0.80.1-0.1
Pavlov. Cond. lever latency1.21.72.6-0.9-0.01.51.61.51.41.61.61.6-1.31.40.7-0.7
Pavlov. Cond. magazine entry latency1.82.66.02.51.6-2.3-2.0-1.7-1.8-1.2-1.4-1.41.0-1.0-1.11.1
Pavlov. Cond. change in total contacts2.05.07.81.70.1-2.7-2.8-2.7-2.8-2.6-2.6-2.52.4-2.4-0.60.6
Pavlov. Cond. index score2.33.66.02.00.6-2.5-2.4-2.2-2.2-2.0-2.0-2.01.7-1.8-1.11.1
Pavlov. Cond. latency score2.13.45.41.80.4-2.3-2.3-2.1-2.1-2.0-2.0-2.01.7-1.8-1.21.2
Pavlov. Cond. lever contacts1.21.72.61.00.1-1.5-1.6-1.5-1.5-1.6-1.6-1.61.3-1.4-0.60.6
Pavlov. Cond. magazine entry number4.25.411.2-3.2-1.83.42.92.52.82.12.22.2-1.71.81.1-1.1
Pavlov. Cond. intertrial magazine entries0.20.41.7-1.3-1.00.90.60.40.50.20.20.2-0.00.10.6-0.6
Pavlov. Cond. lever-magazine prob. diff.2.53.96.92.20.8-2.6-2.5-2.3-2.3-2.1-2.1-2.11.8-1.8-1.01.0
Pavlov. Cond. response bias2.02.84.71.80.6-2.2-2.1-1.9-1.9-1.8-1.8-1.81.5-1.5-1.01.0
Time in closed arm before self-admin0.61.01.8-0.5-1.3-0.5-0.9-1.1-1.0-1.2-1.2-1.11.4-1.3-0.10.1
Time in closed arm after self-admin0.70.81.5-0.6-0.41.11.21.11.10.80.91.1-0.90.90.1-0.1
Time in open arm before self-admin5.06.09.7-0.41.02.32.83.02.73.13.13.0-3.13.10.2-0.2
Time in open arm after self-admin0.20.20.50.30.70.10.20.30.30.70.60.3-0.60.60.2-0.2
Bone: periosteal estimation0.61.53.7-0.1-1.5-0.5-0.9-1.0-0.6-1.4-1.2-1.11.1-1.1-1.91.9
Bone: periosteal perimeter0.71.32.40.4-1.1-0.8-1.1-1.1-0.9-1.4-1.2-1.11.1-1.1-1.61.6
Bone: post-yield work3.35.711.20.8-2.8-1.7-2.2-2.3-2.1-2.7-2.1-1.72.4-2.3-3.33.3
Progressive ratio test 1 active lever presses0.40.72.0-0.6-1.4-0.0-0.7-0.7-0.6-1.1-1.0-0.91.0-1.0-0.40.4
Progressive ratio test 1 breakpoint0.50.82.0-0.5-1.4-0.2-0.8-0.8-0.7-1.2-1.1-1.11.1-1.1-0.50.5
Progressive ratio test 1 inactive lever presses0.20.41.0-0.3-0.6-0.4-0.6-0.8-0.7-0.7-0.7-0.71.0-1.00.3-0.3
Progressive ratio test 2 active lever presses1.52.15.6-1.8-2.40.1-0.9-1.3-0.9-1.7-1.7-1.52.0-1.90.2-0.2
Progressive ratio test 2 breakpoint1.62.15.4-1.7-2.30.1-0.8-1.3-0.9-1.7-1.7-1.52.0-1.90.2-0.2
Progressive ratio test 2 inactive lever presses1.13.412.5-3.3-3.50.9-0.3-1.0-0.6-1.5-1.5-1.22.2-2.11.4-1.4
Incentive Sensitization - Responses0.30.91.4-0.1-0.8-0.7-0.9-1.0-0.8-1.2-1.2-1.01.2-1.1-0.70.7
Incentive Sensitization - Breakpoint0.30.81.3-0.3-0.9-0.6-0.8-1.0-0.8-1.2-1.1-1.01.2-1.1-0.50.5
Sum of active levers in priming session hrs 5-66.05.79.21.00.8-2.6-2.8-2.8-2.6-2.7-2.9-3.02.7-2.81.2-1.2
Progressive ratio0.61.64.71.2-0.8-1.1-1.4-1.2-1.1-1.2-0.8-0.70.9-0.9-2.22.2
Food seeking constrained by brief footshock0.30.30.60.20.30.40.50.70.60.70.70.6-0.80.8-0.30.3
Seeking ratio, punishment vs. effort1.73.75.3-1.40.72.12.32.32.12.32.01.8-2.02.01.7-1.7
Retroperitoneal fat weight2.812.545.9-6.8-5.25.44.03.13.51.92.02.4-1.21.41.5-1.5
Reaction time number correct0.00.10.50.70.6-0.5-0.3-0.1-0.0-0.1-0.1-0.2-0.10.00.3-0.3
Reaction time mean minus median0.74.78.02.20.7-2.8-2.8-2.6-2.6-2.3-2.2-2.32.1-2.1-1.11.1
Reaction time mean minus median AUC0.32.24.01.70.4-2.0-2.0-1.8-1.8-1.5-1.5-1.61.4-1.4-0.40.4
Reaction time num false alarms2.23.75.7-0.80.42.02.32.42.32.32.32.4-2.32.30.5-0.5
Reaction time num false alarms AUC1.22.84.6-0.10.81.51.92.01.92.12.12.1-2.22.10.3-0.3
Reaction time trials correct on left0.00.10.50.70.6-0.5-0.3-0.1-0.0-0.1-0.1-0.2-0.10.00.3-0.3
Reaction time trials on left0.00.10.70.80.7-0.6-0.3-0.1-0.1-0.2-0.1-0.3-0.10.00.3-0.3
Reaction time mean0.51.22.10.2-0.5-1.1-1.3-1.4-1.5-1.3-1.2-1.21.4-1.40.0-0.0
Reaction time mean AUC0.51.32.30.2-0.7-1.1-1.3-1.4-1.5-1.4-1.2-1.21.5-1.50.0-0.0
Median of all reaction times0.40.61.1-0.3-1.0-0.5-0.7-0.9-1.0-0.9-0.7-0.71.1-1.00.1-0.1
Reaction time omissions0.81.33.01.70.5-1.7-1.4-1.2-1.4-1.2-0.9-0.80.9-1.0-0.10.1
Reaction time false alarm rate2.02.74.2-0.70.21.82.02.01.92.02.02.0-1.92.00.1-0.1
Reaction time premature initiation rate1.32.05.51.92.3-0.10.81.10.91.51.41.3-1.81.8-0.80.8
Reaction time premature initiations0.61.88.32.52.9-0.70.30.80.51.21.10.9-1.61.5-0.30.3
Std. dev. reaction times0.72.23.71.30.2-1.9-1.9-1.8-1.9-1.7-1.6-1.51.6-1.6-0.10.1
Reaction time trials completed0.00.10.70.80.7-0.6-0.3-0.1-0.1-0.2-0.1-0.3-0.10.00.3-0.3
Reaction time trials AUC0.00.10.40.60.5-0.3-0.00.10.20.10.1-0.0-0.30.20.3-0.3
Run reversals in cocaine runway, females2.12.33.70.5-0.31.11.51.71.51.51.71.8-1.91.9-1.71.7
Run reversals in cocaine runway, males0.10.10.4-0.6-0.30.50.40.30.50.40.2-0.1-0.30.30.1-0.1
Latency to leave start box in cocaine runway0.10.20.7-0.3-0.80.2-0.0-0.1-0.1-0.3-0.20.00.3-0.2-0.80.8
Latency to leave start box in cocaine runway, F0.00.10.2-0.1-0.2-0.1-0.2-0.2-0.3-0.1-0.1-0.10.3-0.2-0.40.4
Latency to leave start box in cocaine runway, M0.20.20.9-0.1-0.70.30.20.10.3-0.2-0.10.1-0.00.0-0.90.9
Std. dev. time between licks in bursts1.32.53.8-0.21.01.51.81.91.91.91.91.9-1.91.90.2-0.2
Total sessions with >9 infusions0.30.42.1-0.0-1.40.1-0.2-0.3-0.1-0.6-0.4-0.20.4-0.4-1.11.1
Short access day 1 total inactive lever presses0.61.23.4-1.8-1.71.61.41.11.10.50.71.0-0.50.60.4-0.4
Short access day 10 total inactive lever presses0.21.11.8-0.90.31.01.41.21.11.21.21.3-1.01.00.8-0.8
Short access day 1 total infusions0.40.95.9-1.5-2.41.20.70.40.6-0.10.20.50.1-0.1-0.60.6
Short access day 10 total infusions0.91.57.8-0.7-2.80.4-0.4-0.6-0.3-1.0-0.7-0.40.9-0.8-1.91.9
Short access total infusions0.81.16.6-0.7-2.60.90.30.10.4-0.4-0.10.20.2-0.1-1.71.7
Short access day 1 locomotion0.30.52.8-1.5-1.71.00.50.10.4-0.1-0.10.20.3-0.30.1-0.1
Short access day 10 total locomotion0.20.94.7-1.1-2.20.3-0.5-0.6-0.5-1.0-0.9-0.80.9-0.9-0.30.3
Short access total locomotion0.50.84.9-1.4-2.20.6-0.1-0.3-0.2-0.8-0.7-0.40.8-0.8-0.40.4
One hour access (0.3 mA shock)1.31.58.8-3.0-2.41.50.80.30.5-0.4-0.4-0.20.6-0.50.8-0.8
Compulsive drug intake2.74.012.21.53.50.11.52.11.52.32.22.0-2.82.70.4-0.4
One hour access (shock baseline)1.43.614.3-3.2-3.80.9-0.4-1.1-0.7-1.8-1.7-1.42.3-2.20.8-0.8
Social response proportion0.60.81.30.90.1-1.1-1.1-1.1-1.0-0.9-0.9-1.00.8-0.8-0.30.3
Social responses0.10.10.30.50.3-0.5-0.4-0.3-0.20.0-0.0-0.3-0.0-0.00.2-0.2
Social time0.10.10.80.90.7-0.4-0.1-0.00.00.10.20.0-0.30.20.0-0.0
Soleus weight1.44.214.1-3.8-2.83.12.31.72.01.21.41.6-0.60.71.5-1.5
Bone: stiffness2.23.95.82.1-0.1-2.4-2.3-2.2-2.1-2.2-2.0-1.91.7-1.8-1.91.9
Tibialis anterior weight3.311.541.26.44.2-5.0-4.0-3.0-3.0-2.3-2.4-2.81.2-1.4-2.22.2
Time to tail flick, vehicle, before self-admin0.50.62.00.5-0.3-0.6-0.7-0.7-0.6-0.7-0.6-0.60.5-0.5-1.41.4
Time to tail flick, vehicle, after self-admin0.61.16.00.8-0.30.20.00.30.50.60.50.4-0.70.7-2.42.4
Time to tail flick, test, before self-admin1.71.94.4-1.5-2.11.91.61.41.51.11.31.5-1.01.1-0.60.6
Time to tail flick, test, after self-admin0.60.61.30.3-0.1-0.8-1.0-1.0-0.8-0.9-1.0-1.10.9-0.9-0.40.4
Delta time to tail flick, vehicle, before/after SA0.40.51.20.60.20.20.20.50.60.70.70.6-0.80.8-1.11.1
Delta time to tail flick, test, before/after SA2.73.45.51.52.3-2.4-2.1-2.0-2.0-1.6-1.9-2.21.6-1.71.2-1.2
Tibia length2.77.512.11.70.5-3.2-3.4-3.3-3.1-3.2-3.4-3.53.0-3.0-0.30.3
Ambulatory time before self-admin0.82.64.10.7-0.3-1.7-2.0-2.0-1.9-1.8-1.9-1.91.9-1.9-0.60.6
Ambulatory time after self-admin0.30.40.8-0.4-0.7-0.3-0.6-0.7-0.8-0.7-0.6-0.60.9-0.90.5-0.5
Bone: tissue strength0.10.10.20.0-0.3-0.3-0.3-0.4-0.4-0.4-0.3-0.20.4-0.40.3-0.3
Total heroin consumption2.02.37.22.71.9-2.4-1.9-1.5-1.6-1.0-1.0-1.20.8-0.8-0.50.5
Bone: trabecular number1.12.03.21.1-0.3-1.4-1.6-1.5-1.4-1.5-1.4-1.41.3-1.3-1.81.8
Bone: trabecular spacing1.21.82.5-0.70.21.41.51.51.41.61.61.6-1.41.41.3-1.3
Bone: trabecular thickness0.10.10.8-0.6-0.90.30.20.00.0-0.2-0.00.10.2-0.2-0.40.4
Bone: trabecular tissue density0.91.57.2-2.7-1.61.61.00.60.70.30.20.20.2-0.11.7-1.7
Water consumed over 24 hours0.30.53.11.31.8-1.0-0.4-0.2-0.50.10.0-0.1-0.20.10.7-0.7
Number of responses in last shaping day0.30.40.5-0.10.30.50.70.60.60.70.70.7-0.60.60.6-0.6