Hub : Genes

Map4k2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose gene expression Map4k2 0.42 0.11 0.0e+00 0.32 0.31 0.31 0.32 4.3e-36 1.7e-35 2.1e-35 8.9e-36
2 pVTA gene expression Map4k2 0.15 0.09 1.0e-03 0.03 -0 0 0.04 2.6e-02 3.5e-01 3.2e-01 1.2e-02
3 Brain mRNA stability Map4k2 0.05 0.04 9.7e-03 0.01 0.02 0.03 0.01 4.6e-02 7.9e-03 1.1e-03 2.9e-02
4 Eye isoform ratio NM_001415830.1 0.39 0.17 2.2e-03 0.05 0.06 0.17 0.06 5.4e-02 4.5e-02 1.2e-03 4.3e-02
5 BLA gene expression Map4k2 0.25 0.1 3.4e-07 0.04 0.12 0.11 0.1 2.1e-03 8.9e-07 2.2e-06 8.2e-06
6 NAcc gene expression Map4k2 0.22 0.09 0.0e+00 0.15 0.18 0.17 0.17 1.3e-16 6.0e-20 2.8e-19 3.8e-19
7 OFC gene expression Map4k2 0.54 0.24 4.2e-04 0.16 0.19 0.16 0.18 1.1e-04 3.0e-05 1.0e-04 5.9e-05
8 Brain gene expression Map4k2 0.32 0.11 0.0e+00 0.21 0.23 0.21 0.22 3.2e-19 3.6e-21 5.2e-19 2.6e-20
9 PL gene expression Map4k2 0.29 0.13 0.0e+00 0.16 0.18 0.16 0.16 1.4e-17 3.6e-19 1.6e-17 9.4e-18
10 Liver gene expression Map4k2 0.25 0.12 1.0e-10 0.07 0.08 0.07 0.08 8.2e-08 3.7e-09 2.0e-08 1.4e-09
11 Adipose alternative polyA XM_039108503.1 0.07 0.05 3.1e-03 0.02 0.01 0.01 0.01 1.3e-03 3.0e-02 3.1e-02 1.1e-02
12 Adipose alternative polyA NM_001415830.1 0.07 0.05 4.6e-03 0.02 0 0 0.01 2.1e-03 8.6e-02 8.7e-02 1.4e-02
13 Adipose alternative polyA XM_039108503.1 0.08 0.06 3.1e-03 0.02 0 0 0.01 1.9e-03 7.9e-02 8.7e-02 1.7e-02
14 LHb gene expression Map4k2 0.21 0.11 4.1e-03 0 -0.01 -0.01 -0.01 3.1e-01 5.2e-01 6.0e-01 5.9e-01

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14
Bone: apparent density0.20.30.50.6-0.70.3-0.5-0.6-0.6-0.5-0.7-0.6-0.50.5-0.50.50.5
Area under the delay curve0.40.40.6-0.20.6-0.4-0.30.60.60.70.80.70.7-0.70.7-0.7-0.6
BMI with tail0.31.08.22.9-1.60.3-0.9-0.7-0.7-0.3-0.8-0.40.10.1-0.10.10.0
BMI without tail0.30.52.91.7-0.4-0.10.00.30.40.30.50.60.7-0.90.9-0.9-0.6
Body weight0.62.517.74.2-2.51.90.9-1.3-1.2-1.1-1.1-0.8-0.40.1-0.10.10.3
Weight adjusted by age1.51.72.91.7-1.71.71.3-1.3-1.3-1.4-1.2-1.2-1.11.0-1.01.01.0
Bone surface3.66.310.82.8-3.32.80.3-2.7-2.8-2.7-2.8-2.6-2.32.2-2.22.22.2
Bone volume2.74.56.31.5-2.52.0-0.3-2.3-2.4-2.3-2.5-2.3-2.22.2-2.22.22.2
Breakpoint value in progressive ratio session2.12.34.21.9-2.02.01.1-1.7-1.5-1.6-1.3-1.5-1.31.2-1.21.21.2
Number of licking bursts0.30.30.50.5-0.70.70.0-0.7-0.6-0.6-0.6-0.6-0.50.5-0.50.50.5
Context. condit. distance diff. score1.21.42.8-1.71.6-1.6-1.01.31.21.01.21.11.0-0.90.9-0.9-0.9
Locomotion velocity, session 10.70.71.10.10.7-0.5-0.00.90.80.80.90.91.0-1.01.0-1.0-1.0
Locomotion distance, session 10.30.40.80.80.1-0.4-0.20.50.50.90.40.70.8-0.70.7-0.7-0.7
Locomotion velocity, session 20.40.53.81.9-1.10.80.8-0.5-0.4-0.2-0.4-0.2-0.0-0.00.0-0.0-0.0
Locomotion distance, session 20.40.51.01.00.1-0.30.30.50.51.00.50.80.9-0.80.8-0.8-0.8
Locomotion velocity, session 30.70.83.0-0.40.8-1.2-1.71.00.71.10.40.80.8-0.70.7-0.7-0.7
Locomotion distance, session 30.10.10.2-0.20.4-0.4-0.40.40.30.30.30.30.4-0.30.3-0.3-0.3
Stereotopy head waving bouts, day 31.31.53.2-0.81.2-1.7-1.81.41.21.50.81.21.2-1.01.0-1.0-1.0
Stereotopy head waving duration, day 30.50.61.9-0.90.8-1.1-1.40.80.60.90.30.60.5-0.40.4-0.4-0.4
Locomotion velocity, session 70.40.52.7-0.80.6-1.1-1.60.50.40.90.20.50.4-0.20.2-0.2-0.2
Locomotion distance, session 71.11.42.5-0.31.1-1.4-0.41.31.21.61.11.41.3-1.21.2-1.2-1.2
Stereotopy head waving bouts, day 70.80.91.3-0.3-0.60.5-1.1-0.9-1.0-0.9-1.1-1.0-1.01.1-1.11.11.1
Stereotopy head waving duration, day 71.31.62.41.1-1.61.5-0.0-1.5-1.4-1.3-1.4-1.3-1.21.2-1.21.21.2
Locomotion velocity, session 80.50.61.11.10.2-0.10.70.70.70.50.70.70.9-1.01.0-1.0-1.0
Locomotion distance, session 80.30.41.7-0.50.6-1.0-1.30.70.50.60.30.50.5-0.40.4-0.4-0.4
Degree of sensitization distance0.50.50.9-0.10.6-1.0-0.80.70.71.00.40.70.7-0.60.6-0.6-0.6
Degree of sensitization stereotypy2.02.12.70.7-1.61.6-0.4-1.7-1.7-1.5-1.6-1.6-1.51.5-1.51.51.5
Conditioned locomotion0.20.22.21.5-0.70.60.2-0.3-0.3-0.2-0.2-0.10.0-0.10.1-0.1-0.1
Cocaine response after cond. corrected2.32.64.0-1.42.0-1.9-0.81.91.81.81.61.71.6-1.51.5-1.5-1.5
Cocaine response after cond. not corrected1.82.03.1-1.31.8-1.7-0.41.71.61.41.41.51.4-1.31.3-1.3-1.3
Cocaine response before conditioning1.11.31.91.0-1.41.31.4-1.2-1.2-1.3-1.0-1.1-1.01.0-1.01.01.0
Saline control response0.81.16.22.5-1.11.02.3-0.4-0.2-0.30.00.00.3-0.50.5-0.5-0.4
Bone: connectivity density0.71.13.31.8-1.61.20.4-1.2-1.1-1.1-1.1-1.0-0.80.7-0.70.70.7
Bone: cortical apparent density0.20.21.70.6-0.10.71.3-0.20.10.20.30.30.2-0.20.2-0.2-0.2
Bone: cortical area0.91.32.01.0-1.41.20.1-1.2-1.3-1.4-1.3-1.3-1.11.1-1.11.11.1
Bone: cortical porosity0.00.00.40.3-0.2-0.1-0.6-0.2-0.10.2-0.2-0.0-0.10.1-0.10.10.1
Bone: cortical porosity0.10.10.70.8-0.50.2-0.0-0.3-0.10.1-0.2-0.1-0.10.0-0.00.00.0
Bone: cortical thickness0.50.94.72.2-0.91.41.9-0.5-0.2-0.40.1-0.10.1-0.40.4-0.4-0.3
Bone: cortical thickness1.01.21.80.80.6-0.01.20.91.00.81.21.11.2-1.41.4-1.4-1.3
Bone: cortical tissue density0.20.32.10.7-0.20.81.5-0.20.10.20.40.30.2-0.30.3-0.3-0.3
Condit. Reinf. active minus inactive responses0.10.10.20.4-0.00.00.30.10.20.30.20.30.3-0.20.2-0.2-0.2
Condit. Reinf. active-inactive response ratio0.00.00.30.2-0.00.20.5-0.10.10.20.20.20.1-0.10.1-0.1-0.1
Condit. Reinf. active responses0.00.00.00.1-0.2-0.1-0.1-0.1-0.10.1-0.2-0.0-0.10.2-0.20.20.1
Condit. Reinf. inactive responses0.20.20.7-0.3-0.2-0.4-0.9-0.1-0.3-0.2-0.6-0.4-0.30.5-0.50.50.4
Incentive salience index mean0.00.10.30.6-0.1-0.1-0.00.00.10.30.10.30.3-0.20.2-0.2-0.2
Condit. Reinf. lever presses0.20.20.50.6-0.70.2-0.4-0.4-0.5-0.5-0.6-0.5-0.40.4-0.40.40.4
Condit. Reinf. active minus inactive responses0.60.81.2-0.3-0.70.5-0.4-0.8-1.0-0.8-1.0-1.0-1.01.1-1.11.11.1
Condit. Reinf. active-inactive response ratio1.71.82.7-0.8-0.80.3-1.3-1.0-1.3-1.2-1.6-1.5-1.51.6-1.61.61.6
Condit. Reinf. active responses0.30.40.60.3-0.70.7-0.1-0.8-0.7-0.6-0.7-0.6-0.70.7-0.70.70.7
Condit. Reinf. inactive responses0.30.40.70.60.20.10.70.30.60.70.80.80.7-0.80.8-0.8-0.7
Condit. Reinf. lever presses2.83.86.01.8-2.52.30.1-2.2-2.2-2.1-2.1-2.1-1.91.8-1.81.81.8
Condit. Reinf. lever reinforcers received0.70.91.40.6-1.21.20.4-1.2-1.1-0.9-1.0-0.9-1.01.0-1.01.01.0
Conditioned reinforcement - actives2.02.03.0-0.5-1.10.7-0.7-1.2-1.4-1.5-1.6-1.6-1.71.7-1.71.71.7
Conditioned reinforcement - inactives1.71.98.4-2.90.4-0.5-1.3-0.5-0.7-0.9-0.8-1.1-1.41.6-1.61.61.6
Conditioned locomotion1.21.510.9-3.31.5-1.5-1.80.50.20.2-0.1-0.2-0.30.7-0.70.70.5
Patch foraging indifference point 0 sec0.00.00.1-0.30.1-0.3-0.0-0.00.00.2-0.0-0.0-0.10.1-0.10.10.1
Patch foraging indifference point AUC3.03.46.82.3-2.32.61.6-2.0-1.8-2.2-1.5-1.8-1.61.4-1.41.41.4
Delay disc. indifference point, 0s delay1.31.41.9-0.51.2-1.0-0.81.31.21.21.31.31.2-1.41.4-1.4-1.1
Delay disc. indifference point, 16s delay0.20.21.2-1.10.4-0.5-0.8-0.0-0.00.10.0-0.1-0.10.4-0.40.40.2
Delay disc. indifference point, 2s delay0.00.00.2-0.30.2-0.2-0.40.20.1-0.10.10.00.1-0.10.1-0.1-0.0
Delay disc. indifference point, 24s delay1.11.01.5-0.21.0-0.70.61.01.11.11.21.11.2-1.11.1-1.1-1.2
Delay disc. indifference point, 4s delay1.71.72.5-0.31.3-1.10.11.41.41.41.61.61.5-1.51.5-1.5-1.4
Delay disc. indifference point, 8s delay1.11.11.6-0.10.9-0.8-0.31.01.11.21.21.31.2-1.31.3-1.3-1.2
Indifference point function ln k7.19.917.2-3.84.1-4.2-2.03.53.33.42.93.02.8-2.52.5-2.5-2.5
Indifference point function log k7.19.917.2-3.84.1-4.2-2.03.53.33.42.93.02.8-2.52.5-2.5-2.5
Patch foraging total patch changes 0 sec0.10.10.2-0.20.3-0.50.40.30.40.50.40.40.3-0.40.4-0.4-0.4
Patch foraging total patch changes 12 sec1.82.47.52.7-2.22.21.7-1.7-1.4-1.4-1.1-1.2-1.00.8-0.80.80.8
Patch foraging total patch changes 18 sec0.70.91.61.0-1.30.90.8-1.1-1.0-1.2-0.9-1.0-0.90.9-0.90.90.9
Patch foraging total patch changes 24 sec1.01.23.61.9-1.51.61.8-1.0-0.9-1.1-0.7-0.8-0.60.5-0.50.50.5
Patch foraging total patch changes 6 sec0.10.21.31.1-0.40.30.7-0.10.00.10.10.10.2-0.40.4-0.4-0.3
Patch foraging time to switch 0 sec1.21.93.61.7-1.91.2-1.1-1.5-1.5-1.2-1.5-1.3-1.21.2-1.21.21.2
Patch foraging water rate 0 sec1.11.87.0-2.62.1-1.70.01.51.31.01.21.10.8-0.80.8-0.8-0.8
Patch foraging water rate 12 sec5.58.416.4-3.84.0-3.4-0.03.33.12.82.92.82.5-2.42.4-2.4-2.4
Patch foraging water rate 18 sec3.54.77.9-2.32.8-2.6-0.72.52.32.32.12.12.0-1.91.9-1.9-1.9
Patch foraging water rate 24 sec2.23.16.3-2.42.5-2.20.12.11.91.61.71.71.5-1.41.4-1.4-1.4
Patch foraging water rate 6 sec4.26.210.3-2.63.2-2.9-0.02.92.72.52.62.52.4-2.32.3-2.3-2.3
Seeking ratio, delayed vs. immediate footshock0.20.30.9-0.30.5-0.5-0.20.30.50.90.50.80.5-0.40.4-0.4-0.4
Distance traveled before self-admin1.61.72.30.9-1.51.5-0.0-1.5-1.5-1.3-1.4-1.4-1.41.3-1.31.31.3
Distance traveled after self-admin0.70.81.10.5-1.01.10.4-1.0-0.9-0.8-0.9-0.9-1.00.9-0.90.90.9
Extensor digitorum longus weight1.66.234.95.9-3.83.52.3-2.3-2.0-1.8-1.7-1.5-0.90.5-0.50.50.6
Bone: elastic displacement2.42.83.8-1.12.0-1.60.11.91.91.71.81.71.7-1.71.7-1.7-1.7
Bone: elastic work1.21.52.50.90.7-0.40.91.11.21.11.31.31.4-1.61.6-1.6-1.6
Bone: endosteal estimation0.41.07.6-1.30.2-1.3-2.80.2-0.2-0.1-0.7-0.5-0.40.6-0.60.60.6
Bone: endosteal perimeter1.22.49.8-1.5-0.5-0.5-3.1-0.7-1.2-1.1-1.7-1.4-1.41.7-1.71.71.7
Epididymis fat weight0.61.36.7-2.61.2-1.7-2.50.70.40.2-0.00.1-0.20.3-0.30.30.4
Delta time in closed arm before/after self-admin4.03.95.50.01.8-1.6-0.12.12.12.22.02.12.3-2.32.3-2.3-2.3
Delta time in open arm before/after self-admin2.92.84.00.2-1.61.70.6-1.8-1.7-2.0-1.6-1.8-1.91.9-1.91.91.9
Diff in mean of infusions in LGA sessions0.30.31.10.6-0.60.81.1-0.6-0.5-0.7-0.3-0.5-0.50.4-0.40.40.4
Delay discount exponential model param0.30.40.60.1-0.50.40.1-0.5-0.6-0.7-0.8-0.7-0.70.7-0.70.70.7
Extinction: sum of active levers before priming1.71.74.92.2-1.91.91.1-1.5-1.2-1.1-1.0-1.0-0.90.9-0.90.90.9
Active lever presses in extinction session 63.53.35.01.7-2.22.11.1-1.9-1.9-2.2-1.8-2.0-1.81.6-1.61.61.6
Bone: final force1.21.95.62.4-2.01.70.5-1.4-1.4-1.4-1.4-1.3-1.00.9-0.90.90.9
Bone: final moment1.01.74.92.2-1.91.60.5-1.3-1.4-1.3-1.3-1.2-1.00.9-0.90.90.9
Food consumed during 24 hour testing period0.80.91.30.2-0.91.10.9-1.0-1.0-1.2-0.9-1.0-1.01.0-1.01.01.0
Glucose0.50.83.5-1.81.1-1.5-1.90.70.50.70.10.40.2-0.00.0-0.00.0
Heart weight2.02.86.1-2.42.2-2.5-1.21.91.71.81.51.61.4-1.21.2-1.2-1.2
Delay discount hyperbolic model param0.30.40.60.1-0.50.30.1-0.6-0.6-0.6-0.8-0.7-0.70.7-0.70.70.7
Intermittent access intake day 1-15 change1.21.21.8-0.8-0.60.50.5-0.9-1.0-1.3-1.0-1.2-1.31.3-1.31.31.3
Intermittent access intake escalation0.90.91.4-0.8-0.50.40.3-0.8-0.8-1.1-0.9-1.0-1.21.2-1.21.21.2
Intermittent access intake escalation 21.51.42.3-0.4-0.91.00.8-1.1-1.2-1.3-1.1-1.2-1.51.4-1.41.41.5
Intermitt. access day 1 inactive lever presses0.50.53.2-1.80.5-0.6-1.30.10.00.1-0.1-0.1-0.50.4-0.40.40.6
Intermitt. access day 15 inactive lever presses1.41.53.7-1.9-0.0-0.2-1.6-0.7-0.9-0.8-1.1-1.1-1.31.5-1.51.51.4
Intermitt. access escalation Index3.53.15.3-1.82.3-2.3-0.81.91.91.81.71.71.8-1.51.5-1.5-1.6
Intermittent access day 1 total infusions1.92.214.9-2.61.3-2.3-3.90.70.40.6-0.20.00.20.4-0.40.40.1
Intermittent access day 15 total infusions2.12.310.7-3.30.9-1.7-2.90.0-0.4-0.4-0.9-0.9-0.91.4-1.41.41.2
Intermittent access terminal intake (last 3 days)2.32.68.4-2.70.3-1.1-2.9-0.4-0.8-1.0-1.3-1.3-1.31.8-1.81.81.5
Intermittent access total infusions1.82.010.2-2.40.6-1.5-3.2-0.1-0.5-0.4-1.0-0.8-0.81.3-1.31.31.0
Intermittent access day 1 locomotion2.32.48.0-2.11.9-2.6-2.81.41.21.40.70.91.2-0.70.7-0.7-1.0
Intermittent access day 15 total locomotion1.41.56.4-2.50.7-1.1-2.1-0.1-0.4-0.6-0.7-0.8-0.71.3-1.31.30.9
Intermittent access total locomotion2.02.311.1-2.80.8-1.8-3.3-0.0-0.4-0.3-0.9-0.8-0.71.4-1.41.41.0
Intermittent access standard deviation0.60.61.5-1.2-0.1-0.0-0.6-0.4-0.6-0.6-0.7-0.7-1.01.0-1.01.01.0
Left kidney weight0.20.41.6-1.30.0-0.3-0.9-0.2-0.3-0.5-0.5-0.5-0.80.7-0.70.70.8
Right kidney weight0.82.33.4-0.4-1.10.9-1.2-1.3-1.5-1.6-1.7-1.6-1.81.7-1.71.71.8
Cocaine induced anxiety0.60.71.10.0-0.80.50.1-0.8-0.9-1.1-0.9-1.0-1.01.0-1.01.01.0
Post-drug Anxiety2.52.84.91.2-2.21.70.6-1.6-1.7-1.8-1.7-1.7-2.11.5-1.51.52.0
Baseline Anxiety0.40.52.71.6-1.01.01.1-0.3-0.3-0.2-0.1-0.0-0.2-0.30.3-0.30.1
Tail length0.30.94.71.6-0.31.02.20.10.3-0.40.70.30.4-0.90.9-0.9-0.7
Length with tail0.51.78.93.0-1.82.11.9-1.0-0.9-1.1-0.6-0.7-0.4-0.00.0-0.00.2
Length without tail0.61.25.32.3-1.61.50.6-1.1-1.1-0.7-1.1-0.9-0.50.6-0.60.60.4
Times rat made contact with spout0.30.41.20.70.10.21.10.20.50.60.70.70.6-0.60.6-0.6-0.6
Lifetime Intake1.41.611.0-2.30.8-1.8-3.30.30.00.2-0.5-0.3-0.30.7-0.70.70.5
Liver weight, left0.10.11.5-0.20.1-0.0-1.20.20.1-0.00.00.1-0.0-0.10.1-0.10.0
Liver weight, right0.61.01.7-0.30.9-1.1-0.91.31.10.70.90.91.1-1.21.2-1.2-1.0
Locomotor activity2.53.96.2-1.82.5-2.10.12.32.22.02.12.11.9-1.91.9-1.9-1.9
Locomotor testing distance4.47.310.7-2.13.3-2.8-0.03.23.02.72.92.92.7-2.72.7-2.7-2.7
Locomotor testing rearing3.04.67.3-2.02.7-2.2-0.02.52.32.22.32.32.1-2.02.0-2.0-2.1
Locomotion in novel chamber1.41.76.7-2.60.3-0.9-1.9-0.3-0.6-0.7-1.0-1.0-1.31.4-1.41.41.4
Locomotion in novel chamber post-restriction0.60.74.4-2.10.9-1.2-1.70.50.30.10.10.0-0.10.3-0.30.30.3
Fecal boli incidents, locomotor time 13.03.24.90.2-1.81.6-0.6-1.8-1.9-2.2-1.9-2.0-2.21.8-1.81.82.2
Change in fecal boli incidents, locomotor task3.53.34.9-0.11.6-1.8-0.61.91.92.21.82.02.0-2.02.0-2.0-2.0
Time >=10cm from walls, locomotor time 11.71.74.8-0.7-0.7-0.3-2.2-0.9-1.1-1.1-1.5-1.4-1.21.5-1.51.51.4
Bouts of movement, locomotor time 11.41.53.51.3-1.51.91.8-1.6-1.2-0.7-0.9-0.7-1.10.9-0.90.90.9
Total resting periods, locomotor time 11.51.63.11.1-1.51.81.6-1.6-1.3-0.9-1.1-0.9-1.21.1-1.11.11.2
Rest time, locomotor task time 10.30.31.5-1.20.6-0.8-1.00.40.20.20.00.1-0.10.0-0.00.00.1
Distance moved, locomotor task time 10.00.00.10.3-0.0-0.10.10.10.10.10.10.10.2-0.10.1-0.1-0.2
Vertical activity count, locomotor time 10.40.51.7-1.31.1-0.9-0.70.70.60.50.50.50.5-0.30.3-0.3-0.4
Time >=10cm from walls, locomotor time 21.41.52.10.3-1.20.9-0.3-1.4-1.3-1.1-1.4-1.3-1.31.4-1.41.41.3
Bouts of movement, locomotor time 20.20.31.20.7-0.61.10.8-0.7-0.4-0.2-0.1-0.2-0.30.2-0.20.20.3
Total resting periods, locomotor time 20.20.20.80.4-0.50.90.4-0.6-0.4-0.2-0.1-0.2-0.30.2-0.20.20.3
Rest time, locomotor task time 20.91.05.7-1.71.1-1.3-2.40.80.60.80.40.50.3-0.30.3-0.3-0.1
Distance moved, locomotor task time 20.50.52.61.2-0.80.91.6-0.7-0.5-0.5-0.4-0.4-0.30.3-0.30.30.2
Vertical activity count, locomotor time 20.91.01.9-0.21.0-0.71.41.01.00.71.11.01.1-1.01.0-1.0-1.2
Light reinforcement 10.10.10.6-0.40.4-0.20.80.30.30.30.40.30.2-0.30.3-0.3-0.3
Light reinforcement 21.62.13.2-0.9-0.80.4-0.8-1.2-1.5-1.4-1.8-1.8-1.71.8-1.81.81.8
Bone: marrow area0.41.07.8-1.40.4-1.4-2.80.3-0.10.0-0.6-0.3-0.20.5-0.50.50.5
Bone: maximum diameter1.73.14.50.6-1.81.3-0.6-1.7-1.9-2.1-2.1-2.1-1.91.9-1.91.91.9
Bone: maximum force2.03.56.82.5-2.62.0-0.3-2.0-2.1-1.8-2.1-1.9-1.61.6-1.61.61.6
Bone: maximum moment1.62.85.52.3-2.41.8-0.3-1.8-1.9-1.6-1.9-1.7-1.41.4-1.41.41.4
Mean time between licks in bursts1.72.43.60.71.0-0.91.01.51.61.51.71.71.8-1.91.9-1.9-1.9
Mean num. licks in bursts0.60.71.0-0.40.9-0.70.40.80.90.91.00.90.8-0.80.8-0.8-0.8
Cd content in liver0.91.01.8-1.2-0.30.5-0.7-0.7-0.8-1.3-0.8-1.1-1.21.2-1.21.21.2
Co content in liver2.53.04.7-1.32.1-1.30.81.82.01.72.21.91.7-1.81.8-1.8-1.7
Cu content in liver0.10.10.30.6-0.50.50.6-0.5-0.2-0.1-0.1-0.1-0.30.2-0.20.20.2
Fe content in liver0.40.51.20.4-0.50.50.2-0.6-0.8-1.1-0.8-1.0-0.40.9-0.90.90.4
K content in liver0.20.21.61.3-0.70.3-0.5-0.2-0.2-0.1-0.2-0.10.0-0.10.1-0.10.0
Mg content in liver0.10.11.20.3-0.1-0.3-1.10.00.10.5-0.00.20.2-0.00.0-0.0-0.1
Mn content in liver2.62.94.81.8-2.21.90.3-1.9-1.9-1.8-1.8-1.8-1.51.6-1.61.61.5
Na content in liver0.90.91.71.2-1.31.2-0.3-1.0-1.0-1.1-1.1-1.0-1.00.7-0.70.70.9
Rb content in liver0.81.02.5-1.51.3-1.2-1.61.00.91.10.80.90.7-0.60.6-0.6-0.6
Se content in liver2.83.45.6-0.0-1.51.20.1-1.9-2.0-2.1-2.1-2.2-1.92.4-2.42.41.9
Sr content in liver2.11.94.11.9-1.82.01.9-1.5-1.3-1.5-1.0-1.2-1.10.9-0.90.90.9
Zn content in liver0.50.61.51.2-1.01.01.0-0.9-0.8-0.5-0.6-0.6-0.40.6-0.60.60.3
Bone: minimum diameter0.40.74.9-1.20.2-0.9-2.20.0-0.20.1-0.6-0.3-0.40.6-0.60.60.6
Time in familiar zone, hab. session 10.20.21.2-0.60.4-0.7-1.10.30.30.30.20.20.2-0.10.1-0.1-0.1
Time in novel zone, hab. session 11.00.91.2-0.31.0-0.60.51.11.01.01.11.11.0-1.11.1-1.1-1.1
Total zone transitions, hab. session 10.20.21.01.0-0.70.80.1-0.6-0.5-0.2-0.4-0.3-0.30.2-0.20.20.2
Total locomotion distance, hab. session 10.20.32.7-0.60.4-0.7-1.60.30.20.5-0.10.20.1-0.00.0-0.0-0.0
Locomotion velocity, hab. session 10.10.11.2-0.10.0-0.3-1.10.0-0.00.3-0.20.10.00.1-0.10.10.1
Time in familiar zone, hab. session 21.92.02.7-0.21.3-1.30.61.61.61.11.61.41.6-1.61.6-1.6-1.6
Time in novel zone, hab. session 20.60.60.90.3-0.80.9-0.0-1.0-0.9-0.5-0.9-0.7-0.80.8-0.80.80.8
Total zone transitions, hab. session 20.20.22.01.4-0.60.2-0.4-0.2-0.10.4-0.20.20.3-0.20.2-0.2-0.2
Total locomotion distance, hab. session 20.50.62.3-0.00.5-1.0-1.50.70.71.10.40.80.8-0.60.6-0.6-0.6
Locomotion velocity, hab. session 20.30.53.7-0.20.3-1.0-1.90.50.40.80.10.50.4-0.20.2-0.2-0.2
Novel to familiar place preference ratio3.73.84.91.2-2.22.20.8-2.2-2.2-2.2-2.0-2.1-2.02.0-2.02.02.0
Novelty place preference2.72.83.60.8-1.81.80.7-1.9-1.8-1.8-1.7-1.8-1.71.7-1.71.71.7
Time in novel zone, NPP test1.92.02.50.6-1.51.50.7-1.6-1.5-1.6-1.4-1.5-1.41.5-1.51.51.4
Total zone transitions, NPP test0.50.73.92.0-1.41.20.3-0.9-0.8-0.5-0.7-0.5-0.40.3-0.30.30.3
Total locomotion distance, NPP test0.20.21.50.30.1-0.4-1.20.30.30.70.10.50.4-0.40.4-0.4-0.4
Locomotion velocity, NPP test0.10.11.30.3-0.1-0.1-1.10.00.00.5-0.10.20.2-0.10.1-0.1-0.1
Intraocular pressure1.41.93.4-1.0-0.80.60.5-1.2-1.3-1.5-1.4-1.4-1.81.7-1.71.71.8
Delta distance traveled before/after self-admin0.60.60.8-0.20.8-0.60.20.90.90.80.90.90.9-0.90.9-0.9-0.9
Delta ambulatory time before/after self-admin1.01.01.4-0.11.0-0.60.41.11.11.11.11.21.2-1.21.2-1.2-1.2
Parametrial fat weight0.61.27.7-2.10.8-1.5-2.80.60.40.30.10.2-0.20.1-0.10.10.5
Pavlov. Cond. lever latency0.10.10.4-0.60.6-0.3-0.10.40.40.30.40.30.2-0.30.3-0.3-0.3
Pavlov. Cond. magazine entry latency0.30.40.60.5-0.80.7-0.2-0.8-0.7-0.5-0.6-0.5-0.50.6-0.60.60.6
Pavlov. Cond. change in total contacts1.51.72.20.2-1.31.20.1-1.5-1.4-1.2-1.4-1.3-1.41.5-1.51.51.5
Pavlov. Cond. index score0.40.50.70.5-0.80.70.3-0.8-0.8-0.7-0.7-0.7-0.70.7-0.70.70.7
Pavlov. Cond. latency score0.10.10.20.4-0.50.30.1-0.4-0.4-0.4-0.4-0.3-0.30.4-0.40.40.4
Pavlov. Cond. lever contacts0.00.00.00.10.0-0.2-0.10.10.10.10.10.20.2-0.10.1-0.1-0.1
Pavlov. Cond. magazine entry number1.21.42.1-0.71.3-1.4-0.51.41.31.31.21.21.2-1.21.2-1.2-1.2
Pavlov. Cond. intertrial magazine entries0.20.20.9-0.90.1-0.00.4-0.3-0.2-0.4-0.2-0.4-0.50.6-0.60.60.5
Pavlov. Cond. lever-magazine prob. diff.0.50.61.00.8-1.00.90.3-1.0-0.9-0.8-0.8-0.8-0.70.8-0.80.80.8
Pavlov. Cond. response bias0.40.50.80.4-0.80.90.3-0.9-0.8-0.8-0.7-0.7-0.80.8-0.80.80.8
Pavlov. Cond. lever latency1.21.62.2-0.91.4-1.30.11.31.41.41.51.41.3-1.21.2-1.2-1.2
Pavlov. Cond. magazine entry latency1.41.64.52.1-1.81.71.2-1.4-1.2-1.2-1.0-1.0-0.90.7-0.70.70.8
Pavlov. Cond. change in total contacts4.66.38.51.7-2.92.80.4-2.9-2.8-2.6-2.7-2.7-2.62.5-2.52.52.5
Pavlov. Cond. index score2.83.65.71.9-2.42.20.9-2.1-2.1-2.0-2.0-1.9-1.81.7-1.71.71.7
Pavlov. Cond. latency score2.43.04.81.7-2.21.90.6-1.9-1.9-1.8-1.9-1.8-1.61.6-1.61.61.6
Pavlov. Cond. lever contacts1.31.72.40.9-1.51.40.5-1.4-1.5-1.5-1.5-1.5-1.31.2-1.21.21.3
Pavlov. Cond. magazine entry number3.84.79.2-3.03.0-3.0-1.72.52.32.12.01.91.7-1.61.6-1.6-1.6
Pavlov. Cond. intertrial magazine entries0.30.31.7-1.30.8-1.0-0.60.60.50.30.30.30.2-0.10.1-0.1-0.1
Pavlov. Cond. lever-magazine prob. diff.2.83.66.02.1-2.42.31.1-2.2-2.1-2.0-1.9-1.9-1.71.6-1.61.61.6
Pavlov. Cond. response bias2.23.04.71.7-2.22.10.8-1.9-1.9-1.9-1.8-1.8-1.61.5-1.51.51.5
Time in closed arm before self-admin1.21.31.80.2-1.20.80.0-1.2-1.2-1.3-1.3-1.3-1.31.3-1.31.31.3
Time in closed arm after self-admin1.01.01.6-0.31.0-1.3-0.41.11.01.20.91.11.1-1.01.0-1.0-1.0
Time in open arm before self-admin5.66.17.8-0.82.6-2.00.22.52.62.82.72.82.8-2.82.8-2.8-2.8
Time in open arm after self-admin0.10.10.6-0.40.40.10.80.20.40.20.50.40.2-0.30.3-0.3-0.3
Bone: periosteal estimation0.71.53.2-0.1-1.00.2-1.8-0.9-1.2-1.2-1.6-1.4-1.21.3-1.31.31.3
Bone: periosteal perimeter0.91.52.50.3-1.20.6-1.1-1.1-1.3-1.3-1.6-1.4-1.31.3-1.31.31.3
Bone: post-yield work3.85.28.00.6-2.31.1-2.8-2.2-2.4-1.6-2.8-2.3-2.32.6-2.62.62.5
Progressive ratio test 1 active lever presses0.70.73.6-1.90.8-1.0-1.80.20.10.1-0.2-0.2-0.20.5-0.50.50.3
Progressive ratio test 1 breakpoint0.60.63.3-1.80.8-0.9-1.60.20.10.1-0.2-0.2-0.20.5-0.50.50.2
Progressive ratio test 1 inactive lever presses0.50.61.7-1.31.0-1.0-0.80.70.70.90.60.70.4-0.40.4-0.4-0.3
Progressive ratio test 2 active lever presses1.61.75.7-2.40.3-0.9-2.4-0.3-0.6-0.6-1.0-1.0-1.21.4-1.41.41.4
Progressive ratio test 2 breakpoint1.21.37.4-2.70.7-1.2-1.80.0-0.2-0.3-0.6-0.6-0.91.1-1.11.11.0
Progressive ratio test 2 inactive lever presses2.12.411.8-3.40.7-1.4-2.6-0.1-0.4-0.4-0.8-0.8-1.31.5-1.51.51.6
Incentive Sensitization - Responses0.80.81.4-0.8-0.50.1-0.8-0.7-0.8-0.8-0.9-0.9-1.11.1-1.11.11.2
Incentive Sensitization - Breakpoint0.80.91.4-1.0-0.4-0.0-0.9-0.6-0.8-0.8-0.9-0.9-1.11.2-1.21.21.2
Sum of active levers in priming session hrs 5-66.76.58.51.2-2.72.61.3-2.7-2.7-2.9-2.7-2.8-2.82.6-2.62.62.6
Progressive ratio0.91.02.71.7-1.51.0-0.5-1.1-1.1-0.7-1.1-0.8-0.70.8-0.80.80.8
Food seeking constrained by brief footshock0.91.11.50.40.8-0.61.01.01.00.91.11.11.2-1.21.2-1.2-1.2
Seeking ratio, punishment vs. effort3.03.65.7-1.62.4-1.81.02.12.11.72.21.91.9-1.91.9-1.9-1.9
Retroperitoneal fat weight1.34.221.0-4.62.5-3.1-3.91.71.21.20.60.70.4-0.00.0-0.00.0
Reaction time number correct0.10.10.70.8-0.30.30.8-0.1-0.1-0.2-0.1-0.00.0-0.10.1-0.1-0.1
Reaction time mean minus median3.74.97.62.2-2.82.70.7-2.5-2.4-2.3-2.3-2.3-2.12.0-2.02.02.1
Reaction time mean minus median AUC1.92.43.91.6-2.02.00.6-1.8-1.7-1.6-1.6-1.5-1.51.4-1.41.41.4
Reaction time num false alarms3.24.35.6-0.82.1-2.10.32.22.32.42.32.32.3-2.32.3-2.3-2.2
Reaction time num false alarms AUC2.43.34.4-0.11.6-1.50.81.82.02.02.02.02.1-2.12.1-2.1-2.1
Reaction time trials correct on left0.10.10.70.8-0.30.30.8-0.1-0.1-0.2-0.1-0.00.0-0.10.1-0.1-0.1
Reaction time trials on left0.10.10.90.9-0.40.40.9-0.1-0.2-0.2-0.1-0.1-0.0-0.10.1-0.1-0.1
Reaction time mean1.21.62.10.3-1.21.4-0.0-1.5-1.4-1.1-1.4-1.3-1.41.4-1.41.41.4
Reaction time mean AUC1.31.82.40.2-1.31.4-0.1-1.5-1.5-1.2-1.4-1.3-1.51.5-1.51.51.5
Median of all reaction times0.60.91.3-0.2-0.70.9-0.4-1.0-1.0-0.7-1.0-0.9-1.11.1-1.11.11.1
Reaction time omissions0.50.72.01.4-1.21.30.5-1.1-1.0-0.3-0.9-0.6-0.60.5-0.50.50.6
Reaction time false alarm rate2.23.14.0-0.71.8-1.80.11.92.02.01.91.91.9-1.91.9-1.9-1.9
Reaction time premature initiation rate1.51.93.51.90.30.31.50.91.11.11.41.31.6-1.71.7-1.7-1.7
Reaction time premature initiations1.41.96.32.5-0.20.92.30.50.70.71.11.01.3-1.51.5-1.5-1.5
Std. dev. reaction times1.92.73.61.2-1.91.90.3-1.9-1.8-1.6-1.7-1.6-1.61.6-1.61.61.6
Reaction time trials completed0.10.10.90.9-0.40.40.9-0.1-0.2-0.2-0.1-0.1-0.0-0.10.1-0.1-0.1
Reaction time trials AUC0.10.10.60.7-0.10.10.70.10.10.00.10.10.2-0.30.3-0.3-0.3
Run reversals in cocaine runway, females2.92.84.30.61.2-1.4-0.51.61.71.91.61.82.1-2.02.0-2.0-2.0
Run reversals in cocaine runway, males0.10.10.3-0.50.5-0.0-0.30.50.4-0.10.40.20.2-0.30.3-0.3-0.3
Latency to leave start box in cocaine runway0.20.22.0-0.3-0.0-0.3-1.4-0.1-0.10.0-0.2-0.2-0.10.2-0.20.20.2
Latency to leave start box in cocaine runway, F0.10.10.20.0-0.40.4-0.4-0.5-0.4-0.3-0.3-0.4-0.40.5-0.50.50.5
Latency to leave start box in cocaine runway, M0.30.22.4-0.30.3-0.7-1.50.40.20.3-0.00.00.2-0.10.1-0.1-0.1
Std. dev. time between licks in bursts2.63.13.9-0.31.7-1.60.21.92.01.91.91.91.9-2.02.0-2.0-2.0
Total sessions with >9 infusions1.41.65.7-1.51.4-2.0-2.41.31.01.20.60.90.9-0.70.7-0.7-0.7
Short access day 1 total inactive lever presses1.41.65.2-2.31.7-1.9-2.01.21.01.40.70.90.7-0.50.5-0.5-0.5
Short access day 10 total inactive lever presses3.13.45.8-2.22.4-2.2-0.82.01.92.01.81.81.6-1.61.6-1.6-1.5
Short access day 1 total infusions1.41.57.9-1.81.2-2.0-2.80.90.81.20.40.70.5-0.30.3-0.3-0.2
Short access day 10 total infusions1.11.210.5-1.40.7-1.7-3.20.50.30.7-0.20.10.10.2-0.20.20.1
Short access total infusions1.11.27.7-1.31.0-1.8-2.80.90.71.00.30.50.5-0.30.3-0.3-0.4
Short access day 1 locomotion1.41.54.5-1.81.5-2.1-1.91.21.11.20.70.80.8-0.60.6-0.6-0.6
Short access day 10 total locomotion0.80.93.1-1.51.3-1.8-1.30.80.70.90.50.60.9-0.30.3-0.3-0.7
Short access total locomotion1.21.23.3-1.31.4-1.8-1.61.10.91.20.60.81.0-0.60.6-0.6-0.8
One hour access (0.3 mA shock)2.02.313.9-3.71.6-2.2-2.80.60.20.0-0.2-0.3-0.50.9-0.90.90.7
Compulsive drug intake2.22.23.71.70.60.41.70.81.21.21.61.51.7-1.91.9-1.9-1.9
One hour access (shock baseline)3.64.212.1-3.50.1-1.1-2.9-0.7-1.2-1.2-1.7-1.7-2.12.4-2.42.42.3
Social response proportion0.80.91.71.0-1.21.3-0.2-1.0-1.0-1.0-0.9-0.9-0.80.8-0.80.80.8
Social responses0.00.10.20.4-0.20.40.4-0.1-0.0-0.30.0-0.0-0.1-0.10.1-0.1-0.0
Social time0.10.10.60.8-0.20.40.70.00.10.00.10.20.2-0.30.3-0.3-0.3
Soleus weight1.33.813.4-3.72.6-2.9-2.82.01.71.71.31.40.9-0.90.9-0.9-0.6
Bone: stiffness2.43.76.52.2-2.62.1-0.3-2.2-2.2-1.8-2.2-1.9-1.81.8-1.81.81.8
Tibialis anterior weight3.110.643.86.6-4.84.63.5-3.1-2.9-3.1-2.5-2.4-1.81.2-1.21.21.3
Time to tail flick, vehicle, before self-admin0.40.50.80.7-0.90.80.2-0.7-0.7-0.8-0.7-0.7-0.50.6-0.60.60.6
Time to tail flick, vehicle, after self-admin0.60.61.61.30.1-0.30.30.60.70.30.80.71.0-1.01.0-1.0-1.0
Time to tail flick, test, before self-admin1.81.73.6-0.81.4-1.9-1.31.41.31.51.11.31.3-1.21.2-1.2-1.2
Time to tail flick, test, after self-admin0.00.00.30.2-0.10.30.5-0.0-0.1-0.2-0.0-0.0-0.00.0-0.00.00.0
Delta time to tail flick, vehicle, before/after SA0.50.50.80.70.3-0.4-0.00.60.70.60.80.80.9-0.90.9-0.9-0.9
Delta time to tail flick, test, before/after SA2.22.04.71.2-1.52.22.0-1.4-1.3-1.6-1.0-1.2-1.31.1-1.11.11.1
Tibia length3.39.413.21.8-3.53.10.4-3.2-3.4-3.6-3.3-3.5-3.23.0-3.03.03.1
Ambulatory time before self-admin3.03.13.80.7-1.91.6-0.1-1.9-1.9-1.8-1.9-1.9-1.91.9-1.91.91.9
Ambulatory time after self-admin1.01.11.6-0.3-0.80.7-0.5-1.1-1.1-0.9-1.1-1.0-1.21.3-1.31.31.3
Bone: tissue strength0.40.40.60.1-0.70.5-0.1-0.7-0.7-0.5-0.8-0.7-0.70.8-0.80.80.8
Total heroin consumption1.92.27.62.8-2.12.12.3-1.5-1.3-1.1-1.0-1.0-0.80.7-0.70.70.7
Bone: trabecular number1.11.82.40.7-1.51.1-0.3-1.4-1.5-1.4-1.5-1.5-1.41.4-1.41.41.4
Bone: trabecular spacing1.31.72.3-0.51.4-1.20.21.41.51.51.51.51.4-1.41.4-1.4-1.4
Bone: trabecular thickness0.20.20.8-0.90.1-0.3-0.9-0.1-0.20.1-0.3-0.2-0.30.4-0.40.40.4
Bone: trabecular tissue density0.60.85.7-2.41.3-1.2-1.40.60.50.30.30.20.00.1-0.10.10.1
Water consumed over 24 hours0.30.42.41.1-0.51.01.5-0.4-0.1-0.10.10.10.0-0.10.1-0.1-0.1
Number of responses in last shaping day1.01.01.7-1.31.3-1.2-0.31.11.11.11.01.00.8-0.90.9-0.9-0.7