Hub : Genes

Map4k2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose gene expression Map4k2 0.42 0.11 0.0e+00 0.32 0.32 0.32 0.32 2.8e-36 9.3e-36 7.8e-36 7.5e-36
2 Eye isoform ratio NM_001415830.1 0.38 0.17 3.3e-03 0.05 0.08 0.15 0.04 5.5e-02 2.3e-02 2.6e-03 7.8e-02
3 pVTA gene expression Map4k2 0.23 0.1 5.9e-12 0.04 0.11 0.12 0.13 1.7e-04 6.3e-09 8.4e-10 2.5e-10
4 NAcc gene expression Map4k2 0.19 0.07 0.0e+00 0.12 0.15 0.16 0.16 6.1e-17 2.1e-22 5.6e-23 5.4e-23
5 IC gene expression Map4k2 0.26 0.11 7.5e-08 0.04 0.11 0.1 0.13 8.1e-03 2.2e-05 5.0e-05 3.5e-06
6 BLA gene expression Map4k2 0.26 0.11 2.7e-07 0.1 0.12 0.1 0.1 3.5e-06 8.3e-07 5.1e-06 3.6e-06
7 Brain gene expression Map4k2 0.32 0.12 0.0e+00 0.19 0.22 0.19 0.22 1.4e-17 1.7e-20 2.6e-17 5.1e-20
8 PL gene expression Map4k2 0.31 0.14 5.6e-17 0.16 0.16 0.14 0.15 8.1e-17 1.4e-17 6.5e-15 6.8e-16
9 OFC gene expression Map4k2 0.57 0.22 1.6e-04 0.19 0.23 0.2 0.2 2.7e-05 4.1e-06 1.9e-05 2.1e-05
10 LHb gene expression Map4k2 0.22 0.13 4.9e-03 0 -0.01 -0.01 -0.01 2.5e-01 5.9e-01 9.5e-01 5.6e-01
11 Liver gene expression Map4k2 0.26 0.13 2.5e-10 0.07 0.08 0.07 0.08 6.1e-08 8.2e-09 2.7e-08 2.3e-09
12 NAcc intron excision ratio chr1_213074576_213074698 0.02 0.02 5.4e-03 0.01 0.01 0.01 0.01 1.2e-02 3.6e-02 2.0e-02 3.1e-02
13 NAcc intron excision ratio chr1_213074755_213074979 0.02 0.02 6.5e-03 0.01 0 0.01 0 1.0e-02 6.9e-02 3.8e-02 4.3e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13
Bone: apparent density0.50.93.9-0.90.4-0.7-0.7-0.6-0.5-0.6-0.5-0.4-0.4-0.42.0-2.0
Area under the delay curve0.30.40.70.10.10.50.50.60.50.80.80.70.70.70.8-0.8
BMI with tail1.34.621.3-2.31.8-1.3-1.6-1.1-0.9-1.0-0.6-0.4-0.3-0.34.6-4.6
BMI without tail0.51.56.5-1.50.5-0.2-0.00.30.30.60.80.90.90.92.5-2.5
Body weight1.14.918.2-3.7-0.8-2.2-1.8-1.2-1.0-0.9-0.7-0.8-0.0-0.14.3-4.3
Weight adjusted by age0.81.22.6-1.5-1.2-1.6-1.4-1.2-1.1-0.9-1.0-1.2-0.8-0.80.2-0.2
Bone surface3.87.010.4-3.1-0.7-3.2-3.1-2.8-2.6-2.6-2.6-2.6-2.1-2.12.9-2.9
Bone volume2.54.56.0-1.80.2-2.3-2.4-2.3-2.2-2.3-2.2-2.1-2.0-2.02.3-2.3
Breakpoint value in progressive ratio session1.82.14.2-2.0-1.2-2.0-1.9-1.6-1.6-1.1-1.3-1.4-1.0-1.11.1-1.1
Number of licking bursts0.20.30.6-0.6-0.1-0.8-0.7-0.7-0.7-0.6-0.6-0.6-0.5-0.50.0-0.0
Context. condit. distance diff. score1.11.32.81.61.01.71.41.21.31.21.11.00.90.90.0-0.0
Locomotion velocity, session 10.70.71.1-0.1-0.60.60.91.01.00.90.90.81.01.00.8-0.8
Locomotion distance, session 10.60.83.3-0.8-0.10.10.50.60.50.40.60.80.70.81.8-1.8
Locomotion velocity, session 20.80.93.7-1.9-0.9-1.2-0.8-0.5-0.5-0.3-0.3-0.20.00.01.4-1.4
Locomotion distance, session 20.40.61.5-1.0-0.30.00.40.60.50.50.81.00.80.91.2-1.2
Locomotion velocity, session 31.11.34.00.41.31.01.00.91.00.40.70.90.70.72.0-2.0
Locomotion distance, session 30.10.10.20.20.30.40.30.40.40.30.30.30.30.30.5-0.5
Stereotopy head waving bouts, day 31.61.93.50.91.61.51.41.31.50.81.21.41.11.11.9-1.9
Stereotopy head waving duration, day 30.40.51.80.91.30.90.80.60.70.20.50.70.30.30.7-0.7
Locomotion velocity, session 70.60.73.20.61.80.70.60.40.50.10.50.70.20.31.2-1.2
Locomotion distance, session 70.91.22.10.20.61.01.21.21.21.11.31.41.21.21.0-1.0
Stereotopy head waving bouts, day 70.80.91.40.11.2-0.6-1.0-1.1-1.0-1.1-1.0-1.0-1.1-1.10.6-0.6
Stereotopy head waving duration, day 71.21.52.4-1.00.3-1.4-1.6-1.5-1.5-1.3-1.3-1.3-1.3-1.30.6-0.6
Locomotion velocity, session 80.60.71.8-1.0-1.30.00.40.70.70.80.60.51.11.01.1-1.1
Locomotion distance, session 80.50.72.40.51.30.80.60.60.70.30.40.50.40.51.5-1.5
Degree of sensitization distance0.60.61.4-0.00.80.60.60.60.70.40.70.90.60.61.2-1.2
Degree of sensitization stereotypy1.71.82.8-0.70.5-1.5-1.7-1.7-1.7-1.6-1.5-1.6-1.5-1.50.5-0.5
Conditioned locomotion0.30.32.0-1.4-0.6-0.8-0.5-0.3-0.3-0.2-0.1-0.10.10.10.7-0.7
Cocaine response after cond. corrected1.82.23.61.41.01.91.81.81.81.51.71.71.51.50.2-0.2
Cocaine response after cond. not corrected1.31.52.61.10.81.61.51.41.61.21.41.31.21.20.4-0.4
Cocaine response before conditioning1.11.32.1-1.1-0.9-1.4-1.5-1.4-1.4-1.1-1.3-1.3-1.1-1.10.0-0.0
Saline control response1.01.36.7-2.6-2.1-1.4-0.8-0.3-0.30.10.0-0.20.50.41.1-1.1
Bone: connectivity density1.32.05.3-2.0-0.4-1.6-1.5-1.3-1.2-1.0-1.0-1.0-0.7-0.72.3-2.3
Bone: cortical apparent density0.30.41.7-0.3-0.9-0.3-0.1-0.0-0.30.30.20.10.10.1-1.31.3
Bone: cortical area0.61.01.5-1.1-0.3-1.2-1.2-1.1-1.0-1.1-1.1-1.1-0.9-0.90.6-0.6
Bone: cortical porosity0.00.00.2-0.50.1-0.3-0.3-0.2-0.3-0.2-0.00.1-0.1-0.1-0.00.0
Bone: cortical porosity0.10.10.8-0.9-0.4-0.5-0.4-0.3-0.3-0.1-0.00.0-0.0-0.00.3-0.3
Bone: cortical thickness0.71.26.8-2.3-2.6-1.2-0.6-0.2-0.40.30.0-0.20.50.4-0.50.5
Bone: cortical thickness1.11.22.7-0.7-1.60.51.01.21.01.41.31.11.51.50.2-0.2
Bone: cortical tissue density0.30.41.8-0.5-1.1-0.4-0.1-0.0-0.30.30.20.10.10.1-1.31.3
Condit. Reinf. active minus inactive responses0.00.10.1-0.3-0.3-0.20.00.10.00.30.30.30.30.3-0.00.0
Condit. Reinf. active-inactive response ratio0.10.10.7-0.1-0.5-0.2-0.1-0.0-0.20.20.20.20.10.1-0.80.8
Condit. Reinf. active responses0.00.00.2-0.00.4-0.1-0.2-0.2-0.1-0.1-0.00.1-0.1-0.10.3-0.3
Condit. Reinf. inactive responses0.30.31.60.31.30.2-0.1-0.2-0.0-0.5-0.3-0.2-0.4-0.41.0-1.0
Incentive salience index mean0.10.10.5-0.50.1-0.2-0.10.00.00.20.30.30.20.20.7-0.7
Condit. Reinf. lever presses0.50.61.4-0.70.6-0.8-0.9-0.8-0.7-0.8-0.7-0.6-0.6-0.61.2-1.2
Condit. Reinf. active minus inactive responses0.50.61.20.20.7-0.5-0.8-0.9-0.9-1.1-1.0-0.9-1.1-1.10.1-0.1
Condit. Reinf. active-inactive response ratio1.21.43.20.81.8-0.3-0.9-1.1-0.9-1.6-1.4-1.3-1.6-1.50.5-0.5
Condit. Reinf. active responses0.30.50.9-0.40.3-0.7-0.8-0.9-1.0-0.8-0.8-0.7-0.8-0.80.0-0.0
Condit. Reinf. inactive responses0.20.30.7-0.9-0.8-0.20.10.30.00.70.60.50.60.6-0.20.2
Condit. Reinf. lever presses2.43.34.8-1.8-0.1-2.2-2.2-2.1-2.1-2.0-2.0-2.0-1.7-1.71.3-1.3
Condit. Reinf. lever reinforcers received0.60.81.5-0.8-0.1-1.1-1.1-1.1-1.2-1.0-1.0-1.0-1.0-1.00.0-0.0
Conditioned reinforcement - actives2.23.86.6-0.00.6-1.6-2.1-2.4-2.0-2.5-2.5-2.5-2.6-2.6-0.10.1
Conditioned reinforcement - inactives1.62.44.42.11.9-0.0-0.9-1.3-1.0-1.6-1.7-1.7-2.1-2.0-1.11.1
Conditioned locomotion2.12.710.83.32.91.70.60.10.1-0.6-0.6-0.4-1.1-1.0-2.32.3
Patch foraging indifference point 0 sec0.00.00.10.2-0.10.00.10.00.00.00.10.20.00.0-0.40.4
Patch foraging indifference point AUC2.13.16.1-2.0-1.6-2.5-2.2-2.1-2.0-1.6-1.8-2.0-1.5-1.60.1-0.1
Delay disc. indifference point, 0s delay1.01.12.90.40.51.11.00.81.01.11.01.00.90.91.7-1.7
Delay disc. indifference point, 16s delay0.20.20.91.00.80.40.10.1-0.1-0.0-0.10.0-0.2-0.2-0.50.5
Delay disc. indifference point, 2s delay0.20.21.20.40.60.2-0.1-0.10.0-0.0-0.1-0.2-0.1-0.11.1-1.1
Delay disc. indifference point, 24s delay0.60.71.20.2-0.60.70.81.00.81.11.00.91.11.0-0.60.6
Delay disc. indifference point, 4s delay1.21.22.30.30.21.11.01.21.21.51.41.31.31.30.8-0.8
Delay disc. indifference point, 8s delay0.70.81.50.0-0.10.80.91.00.91.21.21.11.11.10.6-0.6
Indifference point function ln k5.08.717.53.72.34.23.73.43.42.82.93.12.42.5-0.70.7
Indifference point function log k5.08.717.53.72.34.23.73.43.42.82.93.12.42.5-0.70.7
Patch foraging total patch changes 0 sec0.10.20.40.1-0.60.30.40.50.40.50.50.50.50.5-0.60.6
Patch foraging total patch changes 12 sec1.72.17.0-2.6-2.1-2.2-1.7-1.4-1.5-0.9-1.0-1.1-0.6-0.70.8-0.8
Patch foraging total patch changes 18 sec0.50.81.7-1.0-0.9-1.3-1.2-1.1-1.0-0.8-0.9-1.0-0.8-0.80.1-0.1
Patch foraging total patch changes 24 sec0.61.03.1-1.8-1.8-1.6-1.1-0.9-0.9-0.6-0.7-0.9-0.3-0.40.1-0.1
Patch foraging total patch changes 6 sec0.20.41.5-1.2-1.0-0.5-0.10.00.00.20.20.20.50.40.8-0.8
Patch foraging time to switch 0 sec1.22.44.5-1.80.5-1.6-1.7-1.6-1.5-1.5-1.3-1.2-1.2-1.22.1-2.1
Patch foraging water rate 0 sec1.43.07.22.70.62.01.91.61.71.31.21.00.90.9-2.52.5
Patch foraging water rate 12 sec4.38.914.53.81.13.83.73.43.42.82.72.72.42.4-2.82.8
Patch foraging water rate 18 sec2.74.27.02.21.22.62.62.52.52.02.12.11.91.9-1.11.1
Patch foraging water rate 24 sec2.33.36.52.61.22.42.22.02.21.71.61.51.41.4-1.51.5
Patch foraging water rate 6 sec4.46.410.42.50.33.13.23.03.12.72.62.52.42.4-1.71.7
Seeking ratio, delayed vs. immediate footshock0.20.20.70.50.60.50.40.50.30.50.70.80.30.4-0.10.1
Distance traveled before self-admin1.51.93.0-0.90.0-1.6-1.7-1.7-1.6-1.5-1.5-1.6-1.5-1.50.9-0.9
Distance traveled after self-admin0.40.50.8-0.5-0.5-0.9-0.8-0.7-0.9-0.6-0.6-0.6-0.7-0.7-0.70.7
Extensor digitorum longus weight2.18.434.7-5.9-3.4-4.0-3.1-2.2-2.2-1.4-1.3-1.5-0.4-0.63.3-3.3
Bone: elastic displacement2.22.53.61.0-0.71.71.91.91.81.81.71.61.71.7-1.41.4
Bone: elastic work1.11.42.7-1.0-1.60.40.91.21.21.51.31.21.61.60.0-0.0
Bone: endosteal estimation0.71.66.71.32.60.80.2-0.10.3-0.7-0.4-0.2-0.5-0.42.3-2.3
Bone: endosteal perimeter1.22.610.31.53.20.2-0.6-0.9-0.5-1.6-1.3-1.1-1.5-1.42.2-2.2
Epididymis fat weight0.72.512.13.43.51.30.3-0.30.2-1.0-1.0-0.8-1.4-1.3-0.20.2
Delta time in closed arm before/after self-admin3.02.85.0-0.3-1.11.31.82.01.92.02.02.02.22.20.5-0.5
Delta time in open arm before/after self-admin2.92.94.9-0.40.2-1.8-2.1-2.2-2.0-1.8-2.0-2.2-2.1-2.1-0.10.1
Diff in mean of infusions in LGA sessions0.10.21.0-0.8-1.0-0.6-0.4-0.2-0.20.0-0.2-0.30.10.00.1-0.1
Delay discount exponential model param0.30.30.60.0-0.0-0.4-0.4-0.5-0.4-0.8-0.7-0.7-0.6-0.7-0.60.6
Extinction: sum of active levers before priming1.01.12.7-1.6-0.6-1.4-1.3-1.1-1.1-0.7-0.7-0.7-0.6-0.61.2-1.2
Active lever presses in extinction session 63.53.55.8-2.0-0.8-2.4-2.4-2.2-1.9-1.9-2.1-2.2-1.7-1.71.1-1.1
Bone: final force1.22.04.4-2.1-0.7-1.8-1.6-1.3-1.2-1.2-1.2-1.2-0.8-0.81.8-1.8
Bone: final moment1.11.74.0-2.0-0.7-1.7-1.5-1.2-1.1-1.1-1.1-1.1-0.7-0.71.7-1.7
Food consumed during 24 hour testing period0.60.91.3-0.3-0.5-1.0-0.9-0.9-1.0-1.0-1.0-1.1-0.9-1.0-1.11.1
Glucose1.21.95.62.02.41.91.41.21.40.71.01.30.60.71.1-1.1
Heart weight2.33.65.21.21.62.32.02.02.21.81.92.11.81.91.9-1.9
Delay discount hyperbolic model param0.20.30.6-0.0-0.2-0.4-0.3-0.4-0.4-0.7-0.6-0.5-0.5-0.6-0.80.8
Intermittent access intake day 1-15 change0.71.42.51.30.8-0.2-0.8-1.1-0.8-1.2-1.3-1.4-1.6-1.6-1.21.2
Intermittent access intake escalation0.81.73.31.20.7-0.5-1.0-1.3-1.1-1.4-1.6-1.6-1.8-1.8-1.21.2
Intermittent access intake escalation 21.31.53.11.10.6-0.5-0.9-1.3-1.0-1.4-1.5-1.5-1.8-1.7-1.01.0
Intermitt. access day 1 inactive lever presses0.00.20.40.4-0.5-0.4-0.0-0.3-0.3-0.2-0.2-0.1-0.5-0.5-0.70.7
Intermitt. access day 15 inactive lever presses0.61.32.81.71.4-0.1-0.5-0.9-0.8-1.4-1.4-1.1-1.6-1.5-0.40.4
Intermitt. access escalation Index1.42.04.32.11.42.01.61.41.41.31.21.40.91.0-1.11.1
Intermittent access day 1 total infusions1.32.114.11.93.81.1-0.0-0.3-0.1-1.1-0.8-0.5-1.0-0.91.4-1.4
Intermittent access day 15 total infusions2.13.212.72.83.60.7-0.6-1.1-0.7-1.8-1.8-1.6-2.1-2.0-0.20.2
Intermittent access terminal intake (last 3 days)2.93.814.92.53.90.5-1.0-1.4-0.9-2.2-2.1-1.9-2.3-2.30.6-0.6
Intermittent access total infusions2.12.513.42.23.70.8-0.4-0.8-0.4-1.6-1.5-1.2-1.6-1.50.9-0.9
Intermittent access day 1 locomotion1.01.29.01.63.01.10.1-0.10.0-0.7-0.5-0.3-0.7-0.60.8-0.8
Intermittent access day 15 total locomotion2.34.114.12.53.80.3-1.2-1.6-1.3-2.2-2.3-2.1-2.5-2.5-0.20.2
Intermittent access total locomotion4.14.921.12.94.60.6-1.1-1.6-1.2-2.3-2.3-2.0-2.6-2.50.4-0.4
Intermittent access standard deviation0.30.52.11.40.90.3-0.1-0.4-0.2-0.7-0.7-0.7-0.9-0.9-0.50.5
Left kidney weight0.20.84.31.72.10.80.0-0.30.1-0.4-0.4-0.4-0.7-0.70.8-0.8
Right kidney weight0.10.41.71.11.30.4-0.0-0.20.0-0.5-0.5-0.5-0.5-0.50.2-0.2
Cocaine induced anxiety0.50.71.2-0.10.0-0.7-1.0-1.1-0.9-0.9-1.0-1.0-1.1-1.10.1-0.1
Post-drug Anxiety0.70.71.1-0.9-0.6-1.0-0.9-1.0-0.8-0.8-0.8-0.8-0.9-0.90.6-0.6
Baseline Anxiety0.60.71.2-0.7-0.90.40.90.90.81.01.01.01.11.10.2-0.2
Tail length0.20.95.7-1.4-2.4-0.50.20.50.40.90.80.51.00.9-0.20.2
Length with tail0.52.210.0-3.0-3.2-1.7-0.7-0.2-0.30.20.1-0.20.80.71.5-1.5
Length without tail0.61.88.6-2.6-2.9-1.3-0.30.20.10.30.20.01.11.01.3-1.3
Times rat made contact with spout0.30.31.4-0.7-1.2-0.20.20.40.20.70.60.60.60.6-0.30.3
Lifetime Intake1.41.711.01.83.31.0-0.0-0.3-0.0-1.0-0.9-0.6-1.0-0.91.0-1.0
Liver weight, left0.71.12.01.20.81.41.41.21.40.90.90.90.90.90.5-0.5
Liver weight, right2.44.17.82.11.02.82.62.42.72.12.02.01.92.00.6-0.6
Locomotor activity2.43.76.01.90.22.42.52.32.42.12.01.91.91.9-1.01.0
Locomotor testing distance3.05.59.02.20.22.83.02.92.92.62.52.42.42.4-0.90.9
Locomotor testing rearing2.24.47.42.1-0.12.62.72.62.52.42.22.12.12.1-0.80.8
Locomotion in novel chamber1.21.57.42.72.71.40.70.20.5-0.4-0.3-0.0-0.7-0.6-0.80.8
Locomotion in novel chamber post-restriction0.61.04.92.21.71.00.3-0.10.0-0.4-0.5-0.3-0.8-0.8-0.90.9
Fecal boli incidents, locomotor time 11.62.34.2-0.10.3-1.3-1.7-2.0-1.7-1.7-1.9-2.0-2.0-2.10.2-0.2
Change in fecal boli incidents, locomotor task1.91.93.50.10.31.31.61.71.71.41.71.91.71.70.3-0.3
Time >=10cm from walls, locomotor time 12.02.16.40.72.5-0.4-1.2-1.4-1.1-1.8-1.6-1.3-1.7-1.61.1-1.1
Bouts of movement, locomotor time 12.02.24.4-1.4-1.9-2.0-1.4-1.3-1.7-0.8-0.7-0.8-1.0-1.0-2.12.1
Total resting periods, locomotor time 11.92.13.7-1.1-1.4-1.8-1.5-1.5-1.8-1.0-0.9-1.0-1.2-1.3-1.91.9
Rest time, locomotor task time 10.40.51.81.31.10.50.3-0.10.1-0.3-0.2-0.1-0.5-0.5-1.11.1
Distance moved, locomotor task time 10.20.31.6-0.30.50.1-0.10.10.10.20.10.20.30.31.3-1.3
Vertical activity count, locomotor time 10.20.51.31.10.91.10.90.80.80.60.50.50.50.50.3-0.3
Time >=10cm from walls, locomotor time 21.11.62.6-0.40.4-1.3-1.5-1.5-1.6-1.6-1.5-1.4-1.6-1.6-0.60.6
Bouts of movement, locomotor time 20.20.41.0-0.7-1.0-0.8-0.6-0.6-0.8-0.2-0.2-0.2-0.4-0.4-0.60.6
Total resting periods, locomotor time 20.10.20.5-0.4-0.6-0.6-0.5-0.5-0.7-0.2-0.2-0.2-0.4-0.4-0.50.5
Rest time, locomotor task time 20.60.83.01.71.71.31.00.60.70.20.40.60.00.1-0.20.2
Distance moved, locomotor task time 20.30.41.7-1.3-1.1-1.0-0.7-0.4-0.6-0.2-0.3-0.4-0.0-0.1-0.10.1
Vertical activity count, locomotor time 20.60.81.30.1-1.00.60.91.10.91.00.90.71.21.1-0.70.7
Light reinforcement 10.10.20.90.3-1.00.10.40.20.10.30.10.20.20.2-1.01.0
Light reinforcement 21.11.73.41.00.7-0.7-0.8-1.2-1.2-1.8-1.8-1.5-1.8-1.8-0.60.6
Bone: marrow area0.71.67.21.32.70.90.30.10.5-0.5-0.30.0-0.4-0.32.3-2.3
Bone: maximum diameter1.22.33.9-0.50.6-1.4-1.7-1.7-1.4-2.0-2.0-1.9-1.7-1.71.0-1.0
Bone: maximum force2.44.38.2-2.5-0.1-2.4-2.3-2.1-1.9-2.0-1.9-1.8-1.5-1.52.9-2.9
Bone: maximum moment2.23.87.4-2.4-0.1-2.2-2.1-1.9-1.7-1.9-1.7-1.6-1.3-1.32.7-2.7
Mean time between licks in bursts0.81.93.2-0.5-1.40.91.31.51.51.71.71.61.81.8-0.10.1
Mean num. licks in bursts0.40.61.00.5-0.40.80.90.90.81.01.00.90.80.8-0.50.5
Cd content in liver1.11.22.21.21.4-0.2-0.8-1.1-1.0-1.1-1.3-1.3-1.5-1.5-0.70.7
Co content in liver2.63.04.71.2-0.81.71.91.81.62.01.81.61.61.6-2.22.2
Cu content in liver0.10.10.50.20.10.0-0.0-0.1-0.20.10.10.2-0.1-0.1-0.70.7
Fe content in liver0.20.21.0-0.4-0.1-0.20.00.10.1-0.1-0.3-0.40.30.31.0-1.0
K content in liver0.50.52.0-0.60.10.20.10.30.50.60.60.50.60.61.4-1.4
Mg content in liver1.01.01.50.70.61.21.11.11.21.21.21.21.01.10.4-0.4
Mn content in liver2.22.44.9-2.1-1.2-2.2-1.9-1.7-1.7-1.6-1.7-1.7-1.2-1.20.6-0.6
Na content in liver0.20.20.5-0.7-0.7-0.5-0.5-0.4-0.2-0.2-0.3-0.5-0.2-0.20.2-0.2
Rb content in liver1.92.23.91.61.22.01.91.71.71.51.61.61.41.4-0.20.2
Se content in liver0.70.91.90.40.8-0.7-0.8-1.0-1.0-1.2-1.4-1.3-1.1-1.1-0.20.2
Sr content in liver1.81.53.7-1.7-1.9-1.7-1.5-1.2-1.3-0.9-1.1-1.2-0.8-0.8-0.20.2
Zn content in liver0.10.10.8-0.5-0.9-0.2-0.10.0-0.10.30.10.20.30.3-0.40.4
Bone: minimum diameter0.61.15.61.22.40.60.1-0.10.1-0.6-0.30.0-0.5-0.51.7-1.7
Time in familiar zone, hab. session 10.20.21.50.51.20.60.30.20.30.20.20.30.10.10.2-0.2
Time in novel zone, hab. session 10.80.81.30.4-0.80.91.11.21.11.11.00.91.11.1-0.20.2
Total zone transitions, hab. session 10.20.31.0-1.0-0.3-0.8-0.5-0.4-0.6-0.4-0.3-0.2-0.2-0.20.4-0.4
Total locomotion distance, hab. session 10.20.32.10.51.40.50.40.30.3-0.10.10.40.00.10.8-0.8
Locomotion velocity, hab. session 10.10.10.80.10.90.10.10.10.0-0.2-0.00.2-0.1-0.00.6-0.6
Time in familiar zone, hab. session 21.51.52.80.3-0.61.31.31.41.61.71.41.21.61.6-0.10.1
Time in novel zone, hab. session 20.50.51.0-0.40.1-0.9-0.8-0.8-1.0-0.9-0.7-0.5-0.8-0.80.2-0.2
Total zone transitions, hab. session 20.60.73.4-1.40.2-0.6-0.3-0.1-0.2-0.10.20.40.20.21.8-1.8
Total locomotion distance, hab. session 20.60.82.2-0.01.20.70.60.70.70.50.71.00.60.71.5-1.5
Locomotion velocity, hab. session 20.50.62.50.21.60.60.40.40.50.10.40.70.20.31.4-1.4
Novel to familiar place preference ratio2.93.25.1-1.2-0.0-2.1-2.3-2.2-2.2-2.0-2.0-2.1-2.0-2.00.4-0.4
Novelty place preference2.12.33.7-0.80.1-1.7-1.9-1.9-1.9-1.7-1.7-1.8-1.7-1.70.2-0.2
Time in novel zone, NPP test1.51.62.6-0.70.0-1.5-1.6-1.6-1.6-1.4-1.4-1.5-1.4-1.40.3-0.3
Total zone transitions, NPP test0.81.23.9-2.0-0.7-1.5-1.1-0.8-0.9-0.7-0.6-0.5-0.3-0.41.6-1.6
Total locomotion distance, NPP test0.30.41.7-0.30.70.20.30.40.30.20.40.60.40.41.3-1.3
Locomotion velocity, NPP test0.10.20.9-0.40.6-0.10.10.10.0-0.10.20.40.10.10.9-0.9
Intraocular pressure1.52.25.41.20.5-0.5-1.1-1.4-1.1-1.3-1.4-1.5-1.7-1.7-2.32.3
Delta distance traveled before/after self-admin1.61.72.40.4-0.51.11.51.61.31.51.51.51.51.5-1.21.2
Delta ambulatory time before/after self-admin1.21.42.20.2-0.61.01.41.51.31.41.51.41.51.5-0.70.7
Parametrial fat weight0.81.810.12.93.21.70.80.20.5-0.3-0.3-0.1-0.7-0.60.0-0.0
Pavlov. Cond. lever latency0.10.10.50.6-0.10.30.40.30.20.20.10.10.10.1-0.70.7
Pavlov. Cond. magazine entry latency0.50.60.9-0.60.5-0.8-1.0-0.9-0.9-0.7-0.7-0.6-0.7-0.71.0-1.0
Pavlov. Cond. change in total contacts1.31.42.5-0.20.4-1.2-1.5-1.5-1.6-1.4-1.3-1.3-1.5-1.50.1-0.1
Pavlov. Cond. index score0.40.50.9-0.5-0.0-0.8-1.0-0.9-0.9-0.7-0.7-0.7-0.7-0.70.1-0.1
Pavlov. Cond. latency score0.10.20.4-0.40.2-0.5-0.6-0.5-0.5-0.4-0.4-0.4-0.4-0.40.4-0.4
Pavlov. Cond. lever contacts0.10.10.5-0.30.3-0.0-0.1-0.10.00.10.10.10.10.10.7-0.7
Pavlov. Cond. magazine entry number0.81.01.80.60.41.21.31.31.41.01.11.11.11.10.3-0.3
Pavlov. Cond. intertrial magazine entries0.50.62.80.9-0.00.1-0.1-0.3-0.3-0.2-0.4-0.4-0.6-0.5-1.71.7
Pavlov. Cond. lever-magazine prob. diff.0.50.71.3-0.70.0-1.0-1.1-1.1-1.1-0.8-0.8-0.8-0.8-0.80.3-0.3
Pavlov. Cond. response bias0.50.61.1-0.5-0.1-0.9-1.0-1.0-1.0-0.8-0.8-0.9-0.8-0.8-0.10.1
Pavlov. Cond. lever latency1.31.72.60.90.11.51.61.51.41.61.61.61.31.4-0.70.7
Pavlov. Cond. magazine entry latency2.12.66.0-2.5-1.6-2.3-2.0-1.7-1.8-1.2-1.4-1.4-1.0-1.01.1-1.1
Pavlov. Cond. change in total contacts3.15.07.8-1.7-0.1-2.7-2.8-2.7-2.8-2.6-2.6-2.5-2.4-2.40.6-0.6
Pavlov. Cond. index score2.73.66.0-2.0-0.6-2.5-2.4-2.2-2.2-2.0-2.0-2.0-1.7-1.81.1-1.1
Pavlov. Cond. latency score2.63.45.4-1.8-0.5-2.3-2.3-2.1-2.1-2.0-2.0-2.0-1.7-1.81.2-1.2
Pavlov. Cond. lever contacts1.21.72.6-1.0-0.2-1.5-1.6-1.5-1.5-1.6-1.6-1.6-1.3-1.40.6-0.6
Pavlov. Cond. magazine entry number4.45.411.23.21.93.42.92.62.82.12.22.21.71.8-1.11.1
Pavlov. Cond. intertrial magazine entries0.30.41.71.31.10.90.60.40.50.20.20.20.00.1-0.60.6
Pavlov. Cond. lever-magazine prob. diff.2.93.96.9-2.2-0.8-2.6-2.5-2.3-2.3-2.1-2.1-2.1-1.8-1.81.0-1.0
Pavlov. Cond. response bias2.02.84.7-1.8-0.7-2.2-2.1-1.9-1.9-1.8-1.8-1.8-1.5-1.51.0-1.0
Time in closed arm before self-admin0.71.01.80.51.2-0.5-0.9-1.1-1.0-1.2-1.2-1.1-1.4-1.30.1-0.1
Time in closed arm after self-admin0.70.81.50.60.41.11.21.11.10.80.91.10.90.9-0.10.1
Time in open arm before self-admin5.56.09.70.4-0.92.32.83.02.73.13.13.03.13.1-0.20.2
Time in open arm after self-admin0.20.20.5-0.3-0.70.10.20.30.30.70.60.30.60.6-0.20.2
Bone: periosteal estimation0.71.53.70.11.5-0.5-0.9-1.0-0.6-1.4-1.2-1.1-1.1-1.11.9-1.9
Bone: periosteal perimeter0.81.32.4-0.41.1-0.8-1.1-1.1-0.9-1.4-1.2-1.1-1.1-1.11.6-1.6
Bone: post-yield work3.95.711.2-0.82.9-1.7-2.2-2.3-2.1-2.7-2.1-1.7-2.4-2.33.3-3.3
Progressive ratio test 1 active lever presses0.60.72.20.61.5-0.0-0.6-0.7-0.6-1.1-1.0-0.9-1.0-1.00.4-0.4
Progressive ratio test 1 breakpoint0.70.82.20.51.5-0.2-0.8-0.8-0.7-1.2-1.1-1.1-1.1-1.10.5-0.5
Progressive ratio test 1 inactive lever presses0.30.41.00.30.6-0.4-0.6-0.8-0.7-0.7-0.7-0.7-1.0-1.0-0.30.3
Progressive ratio test 2 active lever presses1.82.15.71.82.40.1-0.8-1.3-0.9-1.7-1.7-1.5-2.0-1.9-0.20.2
Progressive ratio test 2 breakpoint1.82.15.41.72.30.1-0.8-1.2-0.9-1.7-1.7-1.5-2.0-1.9-0.20.2
Progressive ratio test 2 inactive lever presses2.13.412.13.33.50.9-0.3-1.0-0.6-1.5-1.5-1.2-2.2-2.1-1.41.4
Incentive Sensitization - Responses0.60.81.40.10.7-0.7-0.9-1.0-0.8-1.2-1.2-1.0-1.2-1.10.7-0.7
Incentive Sensitization - Breakpoint0.60.81.30.30.8-0.6-0.8-1.0-0.8-1.2-1.1-1.0-1.2-1.10.5-0.5
Sum of active levers in priming session hrs 5-66.15.79.2-1.0-0.9-2.6-2.8-2.8-2.6-2.7-2.9-3.0-2.7-2.8-1.21.2
Progressive ratio1.01.64.7-1.20.8-1.1-1.4-1.2-1.1-1.2-0.8-0.7-0.9-0.92.2-2.2
Food seeking constrained by brief footshock0.30.30.6-0.2-0.30.40.50.70.60.70.70.60.80.80.3-0.3
Seeking ratio, punishment vs. effort2.53.75.31.4-0.72.12.32.32.12.32.01.82.02.0-1.71.7
Retroperitoneal fat weight2.912.545.96.85.25.44.03.13.51.92.02.41.21.4-1.51.5
Reaction time number correct0.10.10.5-0.7-0.6-0.5-0.3-0.1-0.0-0.1-0.1-0.20.10.0-0.30.3
Reaction time mean minus median1.94.78.0-2.2-0.7-2.8-2.8-2.6-2.6-2.3-2.2-2.3-2.1-2.11.1-1.1
Reaction time mean minus median AUC0.92.24.0-1.7-0.4-2.0-2.0-1.8-1.8-1.5-1.5-1.6-1.4-1.40.4-0.4
Reaction time num false alarms2.73.75.70.8-0.42.02.32.42.32.32.32.42.32.3-0.50.5
Reaction time num false alarms AUC1.82.84.60.1-0.71.51.92.01.92.12.12.12.22.1-0.30.3
Reaction time trials correct on left0.10.10.5-0.7-0.6-0.5-0.3-0.1-0.0-0.1-0.1-0.20.10.0-0.30.3
Reaction time trials on left0.10.10.7-0.8-0.6-0.6-0.3-0.2-0.1-0.2-0.1-0.30.10.0-0.30.3
Reaction time mean0.81.22.1-0.20.5-1.1-1.3-1.4-1.5-1.3-1.2-1.2-1.4-1.4-0.00.0
Reaction time mean AUC0.81.32.3-0.20.7-1.1-1.3-1.4-1.5-1.4-1.2-1.2-1.5-1.5-0.00.0
Median of all reaction times0.40.61.10.31.0-0.5-0.7-0.9-1.0-0.9-0.7-0.7-1.1-1.0-0.10.1
Reaction time omissions0.91.33.0-1.7-0.5-1.7-1.4-1.3-1.4-1.2-0.9-0.8-0.9-1.00.1-0.1
Reaction time false alarm rate2.02.74.20.7-0.11.82.02.01.92.02.02.01.92.0-0.10.1
Reaction time premature initiation rate1.41.95.4-1.9-2.3-0.10.81.10.91.51.41.31.81.80.8-0.8
Reaction time premature initiations1.01.88.2-2.5-2.9-0.70.30.80.51.21.10.91.61.50.3-0.3
Std. dev. reaction times1.22.23.7-1.3-0.2-1.9-1.9-1.8-1.9-1.7-1.6-1.5-1.6-1.60.1-0.1
Reaction time trials completed0.10.10.7-0.8-0.6-0.6-0.3-0.2-0.1-0.2-0.1-0.30.10.0-0.30.3
Reaction time trials AUC0.00.10.4-0.6-0.5-0.3-0.00.10.20.10.1-0.00.30.2-0.30.3
Run reversals in cocaine runway, females2.32.33.7-0.50.31.11.51.71.51.51.71.81.91.91.7-1.7
Run reversals in cocaine runway, males0.10.10.40.60.30.50.40.40.50.40.2-0.10.30.3-0.10.1
Latency to leave start box in cocaine runway0.20.20.70.30.80.2-0.0-0.1-0.1-0.3-0.20.0-0.3-0.20.8-0.8
Latency to leave start box in cocaine runway, F0.00.10.20.10.2-0.1-0.2-0.2-0.3-0.1-0.1-0.1-0.3-0.20.4-0.4
Latency to leave start box in cocaine runway, M0.20.20.90.10.70.30.20.10.3-0.2-0.10.10.00.00.9-0.9
Std. dev. time between licks in bursts1.82.53.80.2-1.01.51.81.91.91.91.91.91.91.9-0.20.2
Total sessions with >9 infusions0.40.42.20.01.50.1-0.2-0.3-0.1-0.6-0.4-0.2-0.4-0.41.1-1.1
Short access day 1 total inactive lever presses0.91.23.41.81.71.61.41.11.10.50.71.00.50.6-0.40.4
Short access day 10 total inactive lever presses0.51.11.80.9-0.31.01.41.21.11.21.21.31.01.0-0.80.8
Short access day 1 total infusions0.70.96.11.52.51.20.70.40.6-0.10.20.5-0.1-0.10.6-0.6
Short access day 10 total infusions1.21.58.00.72.80.4-0.4-0.6-0.3-1.0-0.7-0.4-0.9-0.91.9-1.9
Short access total infusions0.91.17.00.72.70.90.30.10.4-0.4-0.10.2-0.2-0.11.7-1.7
Short access day 1 locomotion0.40.52.81.51.71.00.50.10.4-0.1-0.10.2-0.3-0.3-0.10.1
Short access day 10 total locomotion0.50.94.71.12.20.3-0.5-0.5-0.5-1.0-0.9-0.8-0.9-0.90.3-0.3
Short access total locomotion0.60.85.01.42.20.6-0.1-0.3-0.2-0.8-0.7-0.4-0.8-0.80.4-0.4
One hour access (0.3 mA shock)1.31.58.83.02.41.50.80.40.5-0.4-0.4-0.2-0.6-0.5-0.80.8
Compulsive drug intake3.44.112.5-1.5-3.50.11.52.11.52.32.22.02.82.7-0.40.4
One hour access (shock baseline)2.33.614.43.23.80.9-0.4-1.1-0.7-1.8-1.7-1.4-2.3-2.2-0.80.8
Social response proportion0.70.81.3-0.9-0.1-1.1-1.1-1.1-1.0-0.9-0.9-1.0-0.8-0.80.3-0.3
Social responses0.10.10.3-0.5-0.3-0.5-0.4-0.3-0.20.0-0.0-0.30.0-0.0-0.20.2
Social time0.10.10.8-0.9-0.7-0.4-0.1-0.00.00.10.20.00.30.2-0.00.0
Soleus weight1.44.214.13.82.73.12.31.72.01.21.41.60.60.7-1.51.5
Bone: stiffness2.43.95.9-2.10.1-2.4-2.3-2.2-2.1-2.2-2.0-1.9-1.7-1.81.9-1.9
Tibialis anterior weight3.411.541.2-6.4-4.2-5.0-4.0-3.0-3.0-2.3-2.4-2.8-1.2-1.32.2-2.2
Time to tail flick, vehicle, before self-admin0.60.62.0-0.50.3-0.6-0.7-0.7-0.6-0.7-0.6-0.6-0.5-0.51.4-1.4
Time to tail flick, vehicle, after self-admin0.91.16.0-0.80.40.20.00.30.50.60.50.40.70.72.4-2.4
Time to tail flick, test, before self-admin1.91.94.61.52.11.91.61.41.51.11.31.51.01.10.6-0.6
Time to tail flick, test, after self-admin0.60.61.3-0.30.1-0.8-1.0-1.0-0.8-0.9-1.0-1.1-0.9-0.90.4-0.4
Delta time to tail flick, vehicle, before/after SA0.50.51.2-0.6-0.10.20.20.50.60.70.70.60.80.81.1-1.1
Delta time to tail flick, test, before/after SA3.33.45.5-1.5-2.3-2.4-2.1-2.0-2.0-1.6-1.9-2.2-1.6-1.7-1.21.2
Tibia length2.77.512.1-1.7-0.5-3.2-3.4-3.3-3.1-3.2-3.4-3.5-3.0-3.00.3-0.3
Ambulatory time before self-admin1.72.64.1-0.70.3-1.7-2.0-2.0-1.9-1.8-1.9-1.9-1.9-1.90.6-0.6
Ambulatory time after self-admin0.40.40.80.40.7-0.3-0.6-0.7-0.8-0.7-0.6-0.6-0.9-0.9-0.50.5
Bone: tissue strength0.10.10.2-0.00.3-0.3-0.3-0.4-0.4-0.4-0.3-0.2-0.4-0.4-0.30.3
Total heroin consumption2.02.37.2-2.7-2.0-2.4-1.9-1.5-1.6-1.0-1.0-1.2-0.8-0.80.5-0.5
Bone: trabecular number1.22.03.2-1.10.3-1.4-1.6-1.5-1.4-1.5-1.4-1.4-1.3-1.31.8-1.8
Bone: trabecular spacing1.41.82.50.7-0.21.41.51.51.41.61.61.61.41.4-1.31.3
Bone: trabecular thickness0.10.10.80.60.90.30.20.00.0-0.2-0.00.1-0.2-0.20.4-0.4
Bone: trabecular tissue density1.01.57.22.71.61.61.00.60.70.30.20.2-0.2-0.1-1.71.7
Water consumed over 24 hours0.40.63.2-1.3-1.8-1.0-0.4-0.2-0.50.10.0-0.10.20.1-0.70.7
Number of responses in last shaping day0.30.40.50.1-0.20.50.70.60.60.70.70.70.60.6-0.60.6