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chr1:176,058,408-178,603,594

Best TWAS P=1.128037e-08 · Best GWAS P=1.006737e-08 conditioned to 1

Associated models

#	Tissue	Gene	Modality	RNA phenotype	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	Adipose	Lcmt1	gene expression	ENSRNOG00000014565	0.12	0.07	top1	1	0.07	1.9e-08	-5.4	-5.4	5.8e-08	0.99	0.41	0.58	FALSE
2	Adipose	Lcmt1	mRNA stability	ENSRNOG00000014565	0.09	0.04	top1	1	0.04	4.5e-05	-5.7	-5.7	1.1e-08	0.99	0.09	0.41	TRUE
3	Brain	Tnrc6a	gene expression	ENSRNOG00000024737	0.23	0.11	enet	23	0.14	8.9e-13	-5.6	5.6	2.0e-08	-0.55	0.18	0.82	FALSE
4	Brain	Lcmt1	intron excision ratio	chr1:177952634:177957883	0.04	0.03	blup	1774	0.03	3.8e-04	-5.4	-5.3	9.7e-08	0.98	0.35	0.61	FALSE
5	LHb	Chp2	gene expression	ENSRNOG00000019112	0.57	0.24	top1	1	0.24	1.7e-06	-5.1	5.1	3.0e-07	-0.69	0.17	0.29	FALSE
6	Liver	Rbbp6	gene expression	ENSRNOG00000012806	0.05	0.01	top1	1	0.01	1.0e-02	-5.2	5.2	2.6e-07	-0.83	0.05	0.03	FALSE
7	Liver	Lcmt1	gene expression	ENSRNOG00000014565	0.05	0.00	blup	1774	0.00	3.7e-01	-5.4	-5.4	7.0e-08	0.98	0.19	0.27	FALSE
8	Liver	Lcmt1	intron excision ratio	chr1:177951469:177952543	0.27	0.12	enet	188	0.14	9.6e-16	-5.4	5.2	1.5e-07	-0.86	0.37	0.63	FALSE
9	Liver	Lcmt1	intron excision ratio	chr1:177952440:177952543	0.26	0.11	blup	1774	0.14	1.7e-15	-5.4	-5.4	7.3e-08	0.96	0.37	0.63	FALSE
10	Liver	Lcmt1	intron excision ratio	chr1:177957980:177959889	0.05	0.00	top1	1	0.00	1.8e-01	-5.1	5.1	3.2e-07	-0.97	0.05	0.03	FALSE
11	Liver	Lcmt1	mRNA stability	ENSRNOG00000014565	0.21	0.11	enet	141	0.15	7.4e-16	-5.4	5.5	4.5e-08	-0.92	0.36	0.64	FALSE
12	OFC	Lcmt1	gene expression	ENSRNOG00000014565	0.16	0.01	blup	1769	0.06	1.6e-02	-5.4	-5.2	1.8e-07	0.95	0.34	0.38	FALSE
13	PL	Cacng3	gene expression	ENSRNOG00000012362	0.43	0.20	lasso	6	0.21	1.3e-05	-5.2	-5.2	2.6e-07	0.67	0.52	0.41	FALSE
14	PL2	Lcmt1	gene expression	ENSRNOG00000014565	0.05	0.04	top1	1	0.04	2.7e-03	-5.4	-5.4	6.2e-08	0.99	0.07	0.04	FALSE
15	PL2	Tnrc6a	gene expression	ENSRNOG00000024737	0.15	0.07	top1	1	0.07	7.8e-05	-5.6	5.6	2.7e-08	-0.96	0.10	0.26	FALSE

h2: Heritability estimate for the given transcriptomic model. PP3: Posterior probability of two distinct causal variants. PP4: Posterior probability of a single shared causal variant. joint: Whether the RNA phenotype is in the joint model.