Hub : Traits

Progressive ratio test 2 inactive lever presses

Tags: Behavior · Motivation · Progressive ratio

Project: p50_paul_meyer_2020

4 significantly associated models · 3 unique genes

Significant Loci

# chr p0 p1 # assoc genes # joint models best TWAS P best SNP P cond SNP P % var exp joint genes
1 1 84591076 85984018 1 1 3.5e-07 0.0078 0.34262 87 Zfp14
2 8 108584253 109479622 1 1 4.4e-12 0.0052 0.00025 -72 Apeh
3 11 39057816 40174684 1 1 5.7e-09 0.1063 1.00000 100 Epha6

p0: physical position of the start of the locus. p1: physical position of the end of the locus. # joint models: number of models selected by step-wise conditional analysis.

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Body weight 1.9 1 0 0 0.00 1.00000 Zfp14
Heart weight 4.4 1 0 0 0.00 1.00000 Epha6
Left kidney weight 6.1 1 0 0 0.00 1.00000 Zfp14
Right kidney weight 5.7 1 0 0 0.00 1.00000 Zfp14
Liver weight, left 4.0 1 0 0 0.00 1.00000 Apeh
Parametrial fat weight 15.4 2 1 33 0.00 1.00000 Epha6 Zfp14
Intraocular pressure 5.2 1 0 0 0.00 1.00000 Epha6
Tibia length 2.4 1 0 0 0.00 1.00000 Epha6
Food consumed during 24 hour testing period 5.7 1 0 0 0.00 1.00000 Epha6
Times rat made contact with spout 14.7 1 0 0 0.00 1.00000 Epha6
Std. dev. time between licks in bursts 6.9 1 0 0 0.00 1.00000 Apeh
Water consumed over 24 hours 15.6 1 0 0 0.00 1.00000 Epha6
Indifference point AUC 7.4 1 0 0 0.00 1.00000 Zfp14
Delay discounting total patch changes 12 sec 11.7 1 0 0 0.00 1.00000 Epha6
Delay discounting total patch changes 18 sec 10.7 2 0 0 0.00 1.00000 Epha6 Apeh
Delay discounting total patch changes 6 sec 9.3 2 0 0 0.00 1.00000 Epha6 Apeh
Delay discounting water rate 18 sec 10.6 2 0 0 0.00 1.00000 Epha6 Zfp14
Delay discounting water rate 24 sec 15.4 1 0 0 0.00 1.00000 Zfp14
Locomotor activity 6.3 2 0 0 0.00 1.00000 Epha6 Zfp14
Locomotor testing distance 8.0 1 0 0 0.00 1.00000 Epha6
Reaction time premature initiation rate 8.8 1 0 0 0.00 1.00000 Epha6
Reaction time premature initiations 5.8 1 0 0 0.00 1.00000 Epha6
Conditioned locomotion 14.7 1 0 0 0.00 1.00000 Epha6
Cocaine response before conditioning 7.2 2 0 0 0.00 1.00000 Epha6 Zfp14
Condit. Reinf. lever presses 6.0 1 0 0 0.00 1.00000 Epha6
Pavlov. Cond. lever latency 5.9 1 0 0 0.00 1.00000 Epha6
Pavlov. Cond. lever contacts 7.0 1 0 0 0.00 1.00000 Epha6
Pavlov. Cond. magazine entry number 6.5 1 0 0 0.00 1.00000 Epha6
Conditioned reinforcement - actives 21.1 1 0 0 0.00 1.00000 Epha6
Conditioned reinforcement - inactives 24.8 3 2 67 1.00 0.00091 Epha6 Apeh Zfp14
Conditioned locomotion 6.3 2 0 0 0.00 1.00000 Apeh Zfp14
Intermittent access intake day 1-15 change 26.8 1 1 33 0.00 1.00000 Apeh
Intermittent access intake escalation 21.2 1 0 0 0.00 1.00000 Apeh
Intermittent access intake escalation 2 29.8 1 1 33 0.00 1.00000 Apeh
Intermitt. access day 15 inactive lever presses 27.4 1 1 33 0.00 1.00000 Apeh
Intermitt. access escalation Index 7.2 1 0 0 0.00 1.00000 Zfp14
Intermittent access day 1 total infusions 12.0 2 0 0 0.00 1.00000 Epha6 Zfp14
Intermittent access day 15 total infusions 13.1 2 0 0 0.00 1.00000 Epha6 Zfp14
Intermittent access terminal intake (last 3 days) 19.7 2 0 0 0.00 1.00000 Epha6 Zfp14
Intermittent access total infusions 16.8 2 0 0 0.00 1.00000 Epha6 Zfp14
Intermittent access day 1 locomotion 9.0 1 0 0 0.00 1.00000 Zfp14
Intermittent access standard deviation 34.3 1 1 33 0.00 1.00000 Apeh
Cocaine induced anxiety 12.4 2 0 0 0.00 1.00000 Epha6 Apeh
Post-drug Anxiety 5.9 1 0 0 0.00 1.00000 Epha6
Baseline Anxiety 18.8 1 0 0 0.00 1.00000 Epha6
Lifetime Intake 24.1 2 1 33 0.00 1.00000 Epha6 Zfp14
Incentive Sensitization - Responses 9.1 2 0 0 0.00 1.00000 Epha6 Apeh
Incentive Sensitization - Breakpoint 8.8 2 0 0 0.00 1.00000 Epha6 Apeh
Progressive ratio test 1 active lever presses 17.8 3 1 33 0.61 0.39290 Epha6 Apeh Zfp14
Progressive ratio test 1 breakpoint 19.6 3 1 33 0.62 0.37560 Epha6 Apeh Zfp14
Progressive ratio test 1 inactive lever presses 8.9 2 0 0 0.00 1.00000 Epha6 Apeh
Progressive ratio test 2 active lever presses 23.5 2 1 33 0.00 1.00000 Epha6 Zfp14
Progressive ratio test 2 breakpoint 18.1 2 1 33 0.00 1.00000 Epha6 Zfp14
Total sessions with >9 infusions 14.7 2 0 0 0.00 1.00000 Epha6 Apeh
Short access day 1 total inactive lever presses 7.8 3 0 0 0.98 0.01947 Epha6 Apeh Zfp14
Short access day 10 total inactive lever presses 40.3 1 1 33 0.00 1.00000 Apeh
Short access day 1 total infusions 37.1 1 1 33 0.00 1.00000 Epha6
Short access day 10 total infusions 6.2 1 0 0 0.00 1.00000 Zfp14
Short access total infusions 40.4 1 1 33 0.00 1.00000 Epha6
Short access day 10 total locomotion 6.4 1 0 0 0.00 1.00000 Apeh
Short access total locomotion 10.7 1 0 0 0.00 1.00000 Apeh
Compulsive drug intake 7.7 1 0 0 0.00 1.00000 Apeh
One hour access (0.3 mA shock) 24.9 2 1 33 0.00 1.00000 Epha6 Zfp14
One hour access (shock baseline) 16.8 2 0 0 0.00 1.00000 Epha6 Zfp14
Number of responses in last shaping day 12.0 1 0 0 0.00 1.00000 Apeh
Locomotion distance, session 1 10.1 1 0 0 0.00 1.00000 Epha6
Stereotopy head waving bouts, day 3 8.9 1 0 0 0.00 1.00000 Epha6
Locomotion velocity, session 7 6.8 1 0 0 0.00 1.00000 Epha6
Locomotion distance, session 7 12.3 1 0 0 0.00 1.00000 Epha6
Stereotopy head waving bouts, day 7 6.0 1 0 0 0.00 1.00000 Zfp14
Locomotion distance, session 8 5.0 1 0 0 0.00 1.00000 Epha6
Degree of sensitization stereotypy 11.1 1 0 0 0.00 1.00000 Zfp14
Condit. Reinf. active minus inactive responses 9.4 1 0 0 0.00 1.00000 Epha6
Condit. Reinf. active-inactive response ratio 8.4 1 0 0 0.00 1.00000 Epha6
Condit. Reinf. active responses 7.5 1 0 0 0.00 1.00000 Epha6
Incentive salience index mean 10.8 1 0 0 0.00 1.00000 Epha6
Condit. Reinf. lever presses 8.2 1 0 0 0.00 1.00000 Epha6
Time in familiar zone, hab. session 1 9.3 1 0 0 0.00 1.00000 Epha6
Time in novel zone, hab. session 1 10.2 2 0 0 0.00 1.00000 Epha6 Zfp14
Total zone transitions, hab. session 1 8.1 1 0 0 0.00 1.00000 Epha6
Total locomotion distance, hab. session 1 4.8 1 0 0 0.00 1.00000 Epha6
Locomotion velocity, hab. session 1 8.1 1 0 0 0.00 1.00000 Epha6
Time in familiar zone, hab. session 2 29.9 1 1 33 0.00 1.00000 Epha6
Time in novel zone, hab. session 2 25.2 1 1 33 0.00 1.00000 Epha6
Total zone transitions, hab. session 2 7.4 1 0 0 0.00 1.00000 Epha6
Total locomotion distance, hab. session 2 7.0 2 0 0 0.00 1.00000 Epha6 Zfp14
Locomotion velocity, hab. session 2 8.1 1 0 0 0.00 1.00000 Epha6
Novel to familiar place preference ratio 6.2 1 0 0 0.00 1.00000 Apeh
Novelty place preference 7.0 1 0 0 0.00 1.00000 Apeh
Time in novel zone, NPP test 6.8 1 0 0 0.00 1.00000 Apeh
Pavlov. Cond. lever latency 14.6 1 0 0 0.00 1.00000 Epha6
Pavlov. Cond. magazine entry latency 18.3 3 1 33 -0.64 0.36147 Epha6 Apeh Zfp14
Pavlov. Cond. change in total contacts 7.3 1 0 0 0.00 1.00000 Epha6
Pavlov. Cond. index score 24.3 1 1 33 0.00 1.00000 Epha6
Pavlov. Cond. latency score 22.4 1 1 33 0.00 1.00000 Epha6
Pavlov. Cond. lever contacts 20.5 1 1 33 0.00 1.00000 Epha6
Pavlov. Cond. magazine entry number 12.8 1 0 0 0.00 1.00000 Epha6
Pavlov. Cond. lever-magazine prob. diff. 22.9 1 1 33 0.00 1.00000 Epha6
Pavlov. Cond. response bias 18.2 2 1 33 0.00 1.00000 Epha6 Apeh
Bone: apparent density 8.4 1 0 0 0.00 1.00000 Zfp14
Bone surface 4.1 2 0 0 0.00 1.00000 Epha6 Zfp14
Bone volume 3.8 1 0 0 0.00 1.00000 Zfp14
Bone: connectivity density 4.9 2 0 0 0.00 1.00000 Epha6 Zfp14
Bone: cortical thickness 13.4 1 0 0 0.00 1.00000 Epha6
Bone: endosteal estimation 3.3 1 0 0 0.00 1.00000 Epha6
Bone: marrow area 3.0 1 0 0 0.00 1.00000 Epha6
Bone: maximum diameter 6.1 1 0 0 0.00 1.00000 Epha6
Bone: periosteal perimeter 4.9 1 0 0 0.00 1.00000 Epha6
Bone: stiffness 7.0 1 0 0 0.00 1.00000 Epha6
Bone: trabecular number 5.4 1 0 0 0.00 1.00000 Zfp14
Breakpoint value in progressive ratio session 11.4 1 0 0 0.00 1.00000 Zfp14
Diff in mean of infusions in LGA sessions 8.0 1 0 0 0.00 1.00000 Zfp14
Time in closed arm before self-admin 7.8 1 0 0 0.00 1.00000 Zfp14
Time in open arm before self-admin 10.7 1 0 0 0.00 1.00000 Zfp14
Time to tail flick, test, before self-admin 6.5 1 0 0 0.00 1.00000 Epha6
Delta time to tail flick, vehicle, before/after SA 8.0 1 0 0 0.00 1.00000 Epha6
Ambulatory time before self-admin 10.3 1 0 0 0.00 1.00000 Apeh
Area under the delay curve 6.5 1 0 0 0.00 1.00000 Epha6
Delay disc. indifference point, 0s delay 11.5 1 0 0 0.00 1.00000 Epha6
Delay disc. indifference point, 16s delay 7.5 1 0 0 0.00 1.00000 Zfp14
Delay disc. indifference point, 4s delay 9.3 2 0 0 0.00 1.00000 Epha6 Zfp14
Delay disc. indifference point, 8s delay 7.9 1 0 0 0.00 1.00000 Epha6
Delay discount exponential model param 6.6 1 0 0 0.00 1.00000 Epha6
Delay discount hyperbolic model param 6.7 1 0 0 0.00 1.00000 Epha6
Bouts of movement, locomotor time 1 8.9 2 0 0 0.00 1.00000 Epha6 Zfp14
Total resting periods, locomotor time 1 6.5 1 0 0 0.00 1.00000 Zfp14
Vertical activity count, locomotor time 1 7.2 1 0 0 0.00 1.00000 Epha6
Rest time, locomotor task time 2 5.7 1 0 0 0.00 1.00000 Epha6
Seeking ratio, delayed vs. immediate footshock 11.1 1 0 0 0.00 1.00000 Epha6
Locomotion in novel chamber post-restriction 15.3 1 0 0 0.00 1.00000 Epha6
Run reversals in cocaine runway, males 9.6 1 0 0 0.00 1.00000 Zfp14
Latency to leave start box in cocaine runway 8.5 1 0 0 0.00 1.00000 Epha6
Na content in liver 10.2 1 0 0 0.00 1.00000 Epha6
Rb content in liver 9.2 1 0 0 0.00 1.00000 Zfp14
Se content in liver 11.1 1 0 0 0.00 1.00000 Epha6

chisq ratio: Average Chi2 statistic for the selected genes in the secondary trait, divided by the average statistic for all genes in the secondary trait. # genes+: Shared significant genes at Bonferroni correction. # genes++: Shared significant genes at transcriptome-wide significance. % genes++: Number of [++] genes as a percentage of primary trait’s total joint genes. corr: Correlation of effect sizes across the [+] genes.

Associations by panel

tissue modality # hits % hits/tests avg chisq
Adipose alternative polyA 0 0.000 1.16
Adipose alternative TSS 0 0.000 1.23
Adipose gene expression 0 0.000 1.15
Adipose isoform ratio 0 0.000 1.14
Adipose intron excision ratio 0 0.000 1.05
Adipose mRNA stability 0 0.000 1.14
BLA alternative polyA 0 0.000 1.10
BLA alternative TSS 0 0.000 1.06
BLA gene expression 0 0.000 1.17
BLA isoform ratio 0 0.000 1.15
BLA intron excision ratio 0 0.000 1.10
BLA mRNA stability 0 0.000 1.17
Brain alternative polyA 0 0.000 1.18
Brain alternative TSS 0 0.000 1.20
Brain gene expression 0 0.000 1.15
Brain isoform ratio 0 0.000 1.20
Brain intron excision ratio 0 0.000 1.11
Brain mRNA stability 0 0.000 1.17
Eye alternative polyA 0 0.000 1.50
Eye alternative TSS 0 0.000 1.18
Eye gene expression 0 0.000 1.18
Eye isoform ratio 0 0.000 1.14
Eye intron excision ratio 0 0.000 1.04
Eye mRNA stability 0 0.000 1.25
IL alternative polyA 0 0.000 1.23
IL alternative TSS 0 0.000 1.18
IL gene expression 0 0.000 1.19
IL isoform ratio 0 0.000 1.31
IL intron excision ratio 0 0.000 1.18
IL mRNA stability 0 0.000 1.21
LHb alternative polyA 0 0.000 0.99
LHb alternative TSS 0 0.000 1.22
LHb gene expression 0 0.000 1.18
LHb isoform ratio 0 0.000 1.16
LHb intron excision ratio 0 0.000 1.08
LHb mRNA stability 0 0.000 1.17
Liver alternative polyA 0 0.000 1.08
Liver alternative TSS 0 0.000 1.22
Liver gene expression 1 0.014 1.15
Liver isoform ratio 0 0.000 1.24
Liver intron excision ratio 0 0.000 1.14
Liver mRNA stability 0 0.000 1.20
NAcc alternative polyA 0 0.000 1.06
NAcc alternative TSS 0 0.000 1.22
NAcc gene expression 0 0.000 1.17
NAcc isoform ratio 0 0.000 1.16
NAcc intron excision ratio 0 0.000 1.10
NAcc mRNA stability 0 0.000 1.19
OFC alternative polyA 0 0.000 1.11
OFC alternative TSS 0 0.000 1.13
OFC gene expression 0 0.000 1.21
OFC isoform ratio 0 0.000 1.21
OFC intron excision ratio 0 0.000 1.13
OFC mRNA stability 0 0.000 1.15
PL alternative polyA 0 0.000 1.12
PL alternative TSS 2 0.170 1.24
PL gene expression 0 0.000 1.18
PL isoform ratio 0 0.000 1.19
PL intron excision ratio 0 0.000 1.14
PL mRNA stability 1 0.034 1.22

avg chisq: Average Chi2 (squared Z-score) across all models in this panel for this trait.