Hub : Genes

Sf1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Brain	isoform ratio	XM_039080342.1	0.04	0.02	4.5e-04	0.03	0.04	0.02	0.03	3.9e-04	2.4e-04	8.6e-03	3.9e-04
2	RMTg	alternative TSS	XM_039080429.1	0.18	0.09	3.8e-04	0.12	0.1	0.06	0.1	5.0e-04	1.4e-03	1.2e-02	1.0e-03
3	RMTg	gene expression	Sf1	0.15	0.1	8.7e-03	0	0	-0.01	0	2.5e-01	3.3e-01	5.6e-01	2.7e-01
4	BLA	alternative polyA	XM_039080582.1	0.11	0.07	2.9e-03	0.01	0.02	0.02	0.02	1.1e-01	3.2e-02	3.0e-02	2.7e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bone: apparent density	0.5	0.8	1.7	0.4	-0.6	-0.9	-1.3
Area under the delay curve	0.1	0.1	0.3	0.2	-0.3	-0.4	0.5
BMI with tail	2.0	6.4	8.3	2.6	-2.9	-2.1	-2.5
BMI without tail	1.3	2.7	5.4	2.0	-2.3	-1.0	-0.7
Body weight	2.1	8.7	15.5	3.8	-3.9	0.5	-2.1
Weight adjusted by age	1.6	1.8	2.4	1.3	-1.5	1.2	-1.2
Bone surface	2.5	4.3	10.4	1.7	-1.9	0.5	-3.2
Bone volume	1.4	2.3	8.4	0.5	-0.7	-0.2	-2.9
Breakpoint value in progressive ratio session	1.9	2.1	2.3	1.4	-1.5	1.4	-1.4
Number of licking bursts	0.1	0.2	0.3	0.3	-0.3	0.4	-0.5
Context. condit. distance diff. score	1.1	1.3	1.8	-1.1	1.1	-1.4	0.9
Locomotion velocity, session 1	0.3	0.3	0.7	0.6	-0.4	-0.0	0.9
Locomotion distance, session 1	0.4	0.5	0.9	0.9	-0.7	-0.7	-0.1
Locomotion velocity, session 2	1.5	1.7	3.3	1.8	-1.7	0.4	-0.7
Locomotion distance, session 2	0.4	0.6	1.4	1.2	-1.0	-0.3	0.1
Locomotion velocity, session 3	0.8	0.9	3.2	-0.3	0.5	-1.8	-0.1
Locomotion distance, session 3	0.1	0.1	0.2	-0.1	0.1	-0.4	0.1
Stereotopy head waving bouts, day 3	1.1	1.3	4.5	-0.4	0.6	-2.1	0.1
Stereotopy head waving duration, day 3	0.7	0.9	2.1	-0.8	0.9	-1.4	0.0
Locomotion velocity, session 7	1.2	1.4	3.6	-0.8	1.0	-1.9	-0.5
Locomotion distance, session 7	0.4	0.5	1.5	0.1	0.0	-1.2	0.6
Stereotopy head waving bouts, day 7	0.6	0.7	1.2	-0.8	0.8	-0.5	-1.1
Stereotopy head waving duration, day 7	0.6	0.7	2.1	0.5	-0.6	0.4	-1.4
Locomotion velocity, session 8	1.0	1.2	2.3	1.5	-1.3	0.4	0.7
Locomotion distance, session 8	0.5	0.7	2.7	-0.3	0.4	-1.6	-0.3
Degree of sensitization distance	0.4	0.4	1.5	0.0	0.1	-1.2	-0.0
Degree of sensitization stereotypy	0.6	0.6	2.2	-0.0	0.0	0.5	-1.5
Conditioned locomotion	1.0	1.2	2.1	1.4	-1.4	0.7	-0.3
Cocaine response after cond. corrected	0.9	1.0	1.7	-0.7	0.6	-1.3	1.3
Cocaine response after cond. not corrected	0.7	0.8	1.7	-0.6	0.4	-1.3	1.1
Cocaine response before conditioning	0.4	0.5	1.0	0.5	-0.6	0.7	-1.0
Saline control response	2.7	3.6	6.5	2.5	-2.5	1.2	-0.2
Bone: connectivity density	1.2	1.9	2.8	1.5	-1.7	-0.1	-1.7
Bone: cortical apparent density	0.6	0.8	2.1	0.6	-0.6	1.5	0.7
Bone: cortical area	0.4	0.6	1.8	0.6	-0.6	0.4	-1.3
Bone: cortical porosity	0.0	0.1	0.1	0.1	-0.1	-0.3	-0.3
Bone: cortical porosity	0.3	0.3	0.5	0.7	-0.7	0.1	-0.3
Bone: cortical thickness	2.3	3.8	5.1	2.3	-2.2	2.2	0.4
Bone: cortical thickness	1.4	1.7	2.1	1.3	-1.2	1.1	1.5
Bone: cortical tissue density	0.8	1.0	2.5	0.7	-0.7	1.6	0.7
Condit. Reinf. active minus inactive responses	0.1	0.1	0.2	0.4	-0.5	0.2	0.1
Condit. Reinf. active-inactive response ratio	0.2	0.2	0.4	0.2	-0.3	0.7	0.4
Condit. Reinf. active responses	0.1	0.1	0.2	-0.0	0.0	-0.5	-0.4
Condit. Reinf. inactive responses	0.8	0.9	1.9	-0.5	0.6	-1.4	-1.0
Incentive salience index mean	0.2	0.2	0.4	0.6	-0.7	-0.3	-0.3
Condit. Reinf. lever presses	0.3	0.4	1.0	0.4	-0.5	-0.6	-1.0
Condit. Reinf. active minus inactive responses	0.5	0.6	1.0	-0.9	0.9	-0.3	-1.0
Condit. Reinf. active-inactive response ratio	2.3	2.4	3.2	-1.6	1.5	-1.3	-1.8
Condit. Reinf. active responses	0.1	0.1	0.4	-0.2	0.1	0.2	-0.7
Condit. Reinf. inactive responses	0.6	0.8	1.1	0.9	-1.1	0.7	0.7
Condit. Reinf. lever presses	1.2	1.7	4.2	0.9	-0.8	1.0	-2.1
Condit. Reinf. lever reinforcers received	0.2	0.3	0.8	0.1	-0.2	0.6	-0.9
Conditioned reinforcement - actives	1.0	1.0	1.9	-1.0	1.0	-0.1	-1.4
Conditioned reinforcement - inactives	4.5	5.1	10.5	-3.2	2.9	-1.0	-0.6
Conditioned locomotion	5.5	6.6	12.4	-3.5	3.5	-1.3	0.5
Patch foraging indifference point 0 sec	0.1	0.2	0.5	-0.3	0.7	-0.3	-0.0
Patch foraging indifference point AUC	2.5	2.9	4.1	1.6	-1.7	2.0	-1.4
Delay disc. indifference point, 0s delay	0.4	0.5	1.0	0.1	-0.1	-1.0	0.9
Delay disc. indifference point, 16s delay	0.8	0.8	1.3	-1.1	1.2	-0.7	0.0
Delay disc. indifference point, 2s delay	0.1	0.1	0.4	-0.2	0.0	-0.6	-0.1
Delay disc. indifference point, 24s delay	0.5	0.5	1.7	0.3	-0.4	0.3	1.3
Delay disc. indifference point, 4s delay	0.6	0.6	1.7	0.4	-0.6	-0.5	1.3
Delay disc. indifference point, 8s delay	0.4	0.4	1.0	0.4	-0.5	-0.3	1.0
Indifference point function ln k	5.4	7.5	8.6	-2.5	2.8	-2.9	2.8
Indifference point function log k	5.4	7.5	8.6	-2.5	2.8	-2.9	2.8
Patch foraging total patch changes 0 sec	0.1	0.1	0.2	-0.1	0.5	-0.0	0.5
Patch foraging total patch changes 12 sec	2.6	3.3	4.6	2.1	-2.1	1.8	-1.2
Patch foraging total patch changes 18 sec	0.4	0.5	1.2	0.5	-0.5	0.4	-1.1
Patch foraging total patch changes 24 sec	1.6	2.0	2.7	1.7	-1.5	1.6	-0.5
Patch foraging total patch changes 6 sec	0.4	0.6	1.4	1.2	-0.9	0.3	-0.0
Patch foraging time to switch 0 sec	1.2	1.9	4.7	1.0	-1.3	-0.4	-2.2
Patch foraging water rate 0 sec	2.2	3.5	5.9	-2.1	2.4	-0.4	1.8
Patch foraging water rate 12 sec	4.4	6.8	12.5	-2.4	2.8	-1.0	3.5
Patch foraging water rate 18 sec	1.9	2.6	4.6	-1.3	1.6	-1.3	2.2
Patch foraging water rate 24 sec	1.9	2.7	3.7	-1.7	1.8	-0.9	1.9
Patch foraging water rate 6 sec	2.4	3.5	7.9	-1.4	1.8	-1.1	2.8
Seeking ratio, delayed vs. immediate footshock	0.1	0.1	0.1	-0.2	0.2	-0.3	0.4
Distance traveled before self-admin	0.6	0.7	2.1	0.3	-0.4	0.6	-1.4
Distance traveled after self-admin	0.3	0.3	0.7	0.0	-0.1	0.8	-0.7
Extensor digitorum longus weight	4.2	16.7	28.1	5.3	-5.3	2.4	-2.2
Bone: elastic displacement	1.2	1.3	4.8	-0.3	0.6	0.0	2.2
Bone: elastic work	1.4	1.8	2.4	1.5	-1.4	0.8	1.4
Bone: endosteal estimation	1.9	4.2	9.9	-1.5	1.5	-3.1	-1.6
Bone: endosteal perimeter	2.8	5.8	9.0	-2.1	2.0	-3.0	-2.4
Epididymis fat weight	2.1	5.0	6.9	-2.6	2.5	-2.6	-0.4
Delta time in closed arm before/after self-admin	1.4	1.3	3.7	1.0	-0.6	-0.4	1.9
Delta time in open arm before/after self-admin	0.8	0.7	1.8	-0.4	0.0	1.0	-1.3
Diff in mean of infusions in LGA sessions	0.4	0.5	1.0	0.6	-0.7	1.0	-0.2
Delay discount exponential model param	0.1	0.1	0.3	-0.2	0.4	0.2	-0.6
Extinction: sum of active levers before priming	2.7	2.6	4.1	1.8	-2.0	1.1	-1.4
Active lever presses in extinction session 6	1.8	1.8	2.7	1.1	-1.1	1.4	-1.7
Bone: final force	1.6	2.5	3.4	1.8	-1.9	0.7	-1.7
Bone: final moment	1.4	2.2	3.0	1.7	-1.7	0.6	-1.6
Food consumed during 24 hour testing period	0.3	0.4	1.2	-0.2	0.1	1.1	-0.5
Glucose	2.0	3.0	5.3	-1.8	1.8	-2.3	-0.4
Heart weight	2.3	3.2	4.1	-1.9	1.9	-2.0	1.2
Delay discount hyperbolic model param	0.2	0.2	0.3	-0.3	0.4	0.2	-0.6
Intermittent access intake day 1-15 change	0.8	0.8	1.5	-1.2	1.0	0.2	-0.7
Intermittent access intake escalation	0.7	0.7	1.4	-1.2	1.0	0.0	-0.7
Intermittent access intake escalation 2	0.6	0.6	0.7	-0.8	0.6	0.7	-0.8
Intermitt. access day 1 inactive lever presses	1.8	1.9	3.5	-1.9	1.9	-0.8	-0.0
Intermitt. access day 15 inactive lever presses	2.8	3.0	5.6	-2.4	2.2	-0.9	-0.9
Intermitt. access escalation Index	2.2	2.0	2.9	-1.2	1.2	-1.7	1.5
Intermittent access day 1 total infusions	6.3	7.3	13.1	-2.9	2.8	-3.6	-0.6
Intermittent access day 15 total infusions	7.7	8.7	13.8	-3.7	3.5	-2.9	-0.8
Intermittent access terminal intake (last 3 days)	6.6	7.3	10.5	-3.2	2.9	-2.9	-1.5
Intermittent access total infusions	6.1	6.7	9.1	-3.0	2.8	-3.0	-1.2
Intermittent access day 1 locomotion	4.5	4.7	11.3	-1.9	2.0	-3.4	0.3
Intermittent access day 15 total locomotion	4.5	4.8	8.3	-2.9	2.5	-2.1	-0.7
Intermittent access total locomotion	7.5	8.6	12.7	-3.3	3.0	-3.6	-1.3
Intermittent access standard deviation	1.1	1.1	2.3	-1.5	1.4	-0.3	-0.5
Left kidney weight	0.5	1.5	2.6	-1.6	1.4	-0.9	-0.6
Right kidney weight	0.4	1.2	2.0	-1.2	1.0	-0.1	-1.4
Cocaine induced anxiety	0.2	0.3	1.0	-0.2	0.0	-0.1	-1.0
Post-drug Anxiety	1.2	1.4	3.8	0.7	-0.7	0.8	-2.0
Baseline Anxiety	1.5	1.6	2.8	1.7	-1.5	1.1	-0.2
Tail length	1.1	3.4	4.5	2.0	-2.0	2.1	1.0
Length with tail	1.4	5.3	8.2	2.9	-2.7	2.3	-0.5
Length without tail	0.9	2.0	3.4	1.8	-1.6	1.2	-1.0
Times rat made contact with spout	0.7	0.8	1.1	1.0	-1.0	0.9	0.6
Lifetime Intake	5.1	5.7	9.4	-2.6	2.5	-3.1	-0.8
Liver weight, left	0.1	0.1	0.2	-0.2	0.2	-0.5	-0.2
Liver weight, right	0.3	0.4	1.3	0.3	-0.4	-1.2	0.5
Locomotor activity	1.2	2.0	5.5	-0.9	1.0	-0.6	2.4
Locomotor testing distance	1.9	3.1	10.1	-0.9	1.0	-0.8	3.2
Locomotor testing rearing	1.4	2.1	6.0	-0.9	1.0	-0.7	2.4
Locomotion in novel chamber	4.4	5.4	9.1	-3.0	2.9	-1.9	-0.9
Locomotion in novel chamber post-restriction	2.3	2.7	4.5	-2.1	2.1	-1.4	0.2
Fecal boli incidents, locomotor time 1	1.1	1.3	4.6	-0.5	0.2	0.2	-2.2
Change in fecal boli incidents, locomotor task	1.0	0.9	2.2	0.7	-0.5	-0.9	1.5
Time >=10cm from walls, locomotor time 1	3.0	3.0	4.7	-1.4	1.2	-2.2	-2.0
Bouts of movement, locomotor time 1	1.7	1.8	6.0	0.8	-0.7	2.4	-0.4
Total resting periods, locomotor time 1	1.2	1.3	4.2	0.5	-0.5	2.0	-0.7
Rest time, locomotor task time 1	0.8	0.9	1.7	-1.2	1.3	-0.5	0.2
Distance moved, locomotor task time 1	0.2	0.2	0.4	0.3	-0.6	-0.6	-0.3
Vertical activity count, locomotor time 1	0.8	0.8	1.2	-1.1	0.9	-0.9	0.6
Time >=10cm from walls, locomotor time 2	0.4	0.4	1.4	-0.4	0.3	0.3	-1.2
Bouts of movement, locomotor time 2	0.6	0.6	2.0	0.5	-0.5	1.4	0.0
Total resting periods, locomotor time 2	0.3	0.3	1.2	0.3	-0.2	1.1	-0.0
Rest time, locomotor task time 2	1.8	2.1	3.5	-1.7	1.9	-1.4	0.3
Distance moved, locomotor task time 2	0.8	1.0	1.6	1.1	-1.3	1.0	-0.2
Vertical activity count, locomotor time 2	0.6	0.7	2.2	0.4	-0.5	0.4	1.5
Light reinforcement 1	0.1	0.3	0.6	-0.3	0.4	0.5	0.7
Light reinforcement 2	1.9	2.5	4.3	-1.8	2.1	-0.6	-1.4
Bone: marrow area	2.0	4.3	10.3	-1.5	1.5	-3.2	-1.5
Bone: maximum diameter	0.7	1.2	4.8	-0.2	0.1	-0.3	-2.2
Bone: maximum force	1.9	3.3	7.5	1.6	-1.7	-0.0	-2.7
Bone: maximum moment	1.6	2.8	6.4	1.5	-1.6	-0.1	-2.5
Mean time between licks in bursts	1.3	1.8	2.5	1.6	-1.4	0.4	1.6
Mean num. licks in bursts	0.2	0.2	0.9	-0.0	0.1	0.0	1.0
Cd content in liver	0.9	0.9	2.3	-1.5	1.1	0.0	-0.5
Co content in liver	1.8	2.1	7.3	-0.4	0.4	0.8	2.7
Cu content in liver	0.2	0.2	0.4	0.4	-0.6	0.5	-0.2
Fe content in liver	0.1	0.1	0.4	0.2	-0.4	-0.1	-0.6
K content in liver	1.2	1.2	2.0	1.2	-1.4	-0.6	-0.9
Mg content in liver	0.4	0.4	1.1	0.1	-0.2	-1.1	-0.6
Mn content in liver	1.4	1.6	3.0	1.1	-1.0	1.0	-1.7
Na content in liver	0.7	0.7	1.1	0.8	-0.7	0.7	-1.0
Rb content in liver	1.0	1.2	1.7	-1.2	1.2	-1.3	0.6
Se content in liver	1.0	1.2	3.4	-0.9	0.7	-0.1	-1.9
Sr content in liver	2.7	2.4	4.7	1.5	-1.5	2.2	-0.6
Zn content in liver	0.5	0.6	0.8	0.9	-0.8	0.8	-0.5
Bone: minimum diameter	1.6	3.0	6.2	-1.4	1.3	-2.5	-1.3
Time in familiar zone, hab. session 1	0.3	0.3	0.8	-0.5	0.4	-0.9	-0.1
Time in novel zone, hab. session 1	0.5	0.5	1.7	0.2	0.0	0.2	1.3
Total zone transitions, hab. session 1	0.3	0.4	0.6	0.8	-0.7	0.6	-0.4
Total locomotion distance, hab. session 1	0.4	0.6	1.4	-0.6	0.7	-1.2	-0.3
Locomotion velocity, hab. session 1	0.1	0.2	0.5	-0.2	0.3	-0.7	-0.4
Time in familiar zone, hab. session 2	0.8	0.8	2.1	0.7	-0.8	-0.3	1.4
Time in novel zone, hab. session 2	0.2	0.2	0.6	-0.2	0.2	0.3	-0.8
Total zone transitions, hab. session 2	0.7	0.9	1.6	1.3	-1.2	-0.4	-0.8
Total locomotion distance, hab. session 2	0.4	0.6	2.2	0.1	-0.1	-1.5	-0.2
Locomotion velocity, hab. session 2	0.6	0.9	3.0	-0.2	0.3	-1.7	-0.6
Novel to familiar place preference ratio	1.2	1.2	3.7	0.3	-0.5	0.9	-1.9
Novelty place preference	0.8	0.8	2.5	-0.0	-0.2	0.7	-1.6
Time in novel zone, NPP test	0.5	0.5	1.8	0.0	-0.2	0.6	-1.3
Total zone transitions, NPP test	1.1	1.6	2.7	1.6	-1.6	0.5	-1.0
Total locomotion distance, NPP test	0.1	0.2	0.6	0.3	-0.2	-0.8	-0.2
Locomotion velocity, NPP test	0.1	0.1	0.3	0.2	-0.1	-0.5	-0.3
Intraocular pressure	1.0	1.5	2.8	-1.7	1.3	0.4	-1.0
Delta distance traveled before/after self-admin	0.3	0.3	1.1	0.1	-0.1	0.1	1.0
Delta ambulatory time before/after self-admin	0.4	0.5	1.7	0.3	-0.2	0.2	1.3
Parametrial fat weight	2.2	4.3	7.8	-2.2	2.0	-2.8	-0.8
Pavlov. Cond. lever latency	0.2	0.3	0.5	-0.5	0.6	0.3	0.7
Pavlov. Cond. magazine entry latency	0.2	0.3	0.8	0.2	-0.4	-0.1	-0.9
Pavlov. Cond. change in total contacts	0.5	0.6	2.0	-0.5	0.3	0.2	-1.4
Pavlov. Cond. index score	0.2	0.2	0.5	0.2	-0.4	0.3	-0.7
Pavlov. Cond. latency score	0.1	0.1	0.3	0.2	-0.3	-0.1	-0.6
Pavlov. Cond. lever contacts	0.1	0.1	0.1	0.2	-0.3	-0.4	-0.1
Pavlov. Cond. magazine entry number	0.4	0.5	0.9	-0.1	0.3	-1.0	0.9
Pavlov. Cond. intertrial magazine entries	0.5	0.6	1.2	-1.1	1.1	0.2	0.1
Pavlov. Cond. lever-magazine prob. diff.	0.3	0.4	0.8	0.4	-0.6	0.4	-0.9
Pavlov. Cond. response bias	0.1	0.2	0.4	0.0	-0.2	0.5	-0.6
Pavlov. Cond. lever latency	0.5	0.6	2.4	-0.3	0.2	-0.2	1.5
Pavlov. Cond. magazine entry latency	2.0	2.3	3.6	1.7	-1.9	1.2	-1.1
Pavlov. Cond. change in total contacts	1.5	2.1	6.7	0.4	-0.5	1.1	-2.6
Pavlov. Cond. index score	1.4	1.8	4.2	1.0	-1.1	0.9	-2.0
Pavlov. Cond. latency score	1.2	1.5	4.0	0.9	-1.0	0.6	-2.0
Pavlov. Cond. lever contacts	0.4	0.6	1.7	0.3	-0.2	0.7	-1.3
Pavlov. Cond. magazine entry number	3.6	4.3	5.2	-2.2	2.3	-2.0	1.9
Pavlov. Cond. intertrial magazine entries	0.6	0.8	1.3	-1.1	1.0	-1.0	0.2
Pavlov. Cond. lever-magazine prob. diff.	1.7	2.1	3.9	1.3	-1.4	1.1	-2.0
Pavlov. Cond. response bias	1.1	1.5	2.8	1.0	-0.9	1.2	-1.7
Time in closed arm before self-admin	0.5	0.5	2.0	-0.3	0.1	-0.2	-1.4
Time in closed arm after self-admin	0.3	0.3	0.9	0.1	0.1	-0.9	0.7
Time in open arm before self-admin	1.8	1.9	7.5	0.3	-0.2	-0.2	2.7
Time in open arm after self-admin	0.4	0.4	0.8	-0.1	0.0	0.9	0.9
Bone: periosteal estimation	1.0	2.0	4.3	-0.7	0.6	-1.7	-2.1
Bone: periosteal perimeter	0.7	1.1	3.5	-0.3	0.2	-0.9	-1.9
Bone: post-yield work	4.0	5.4	15.4	-0.7	0.7	-2.3	-3.9
Progressive ratio test 1 active lever presses	2.5	2.7	4.5	-2.1	2.1	-1.3	0.0
Progressive ratio test 1 breakpoint	2.1	2.2	3.9	-2.0	1.9	-1.1	0.1
Progressive ratio test 1 inactive lever presses	0.8	0.9	1.3	-1.1	1.1	-0.7	0.7
Progressive ratio test 2 active lever presses	4.6	4.9	8.3	-2.9	2.7	-1.9	-0.9
Progressive ratio test 2 breakpoint	4.8	5.4	9.5	-3.1	3.0	-1.7	-0.3
Progressive ratio test 2 inactive lever presses	7.4	8.5	15.4	-3.9	3.5	-2.4	-0.8
Incentive Sensitization - Responses	1.0	1.0	1.5	-1.2	1.0	-0.7	-1.0
Incentive Sensitization - Breakpoint	1.2	1.2	2.0	-1.4	1.2	-0.8	-1.0
Sum of active levers in priming session hrs 5-6	2.1	2.0	4.8	0.2	-0.3	1.7	-2.2
Progressive ratio	1.5	1.7	3.3	1.3	-1.4	-0.4	-1.8
Food seeking constrained by brief footshock	0.5	0.7	1.2	0.8	-0.8	0.1	1.1
Seeking ratio, punishment vs. effort	1.8	2.1	7.4	-0.7	0.8	0.0	2.7
Retroperitoneal fat weight	4.1	13.5	19.5	-4.4	4.4	-3.9	0.1
Reaction time number correct	0.2	0.3	0.6	0.8	-0.6	0.7	0.1
Reaction time mean minus median	2.1	2.7	5.5	1.2	-1.5	1.2	-2.3
Reaction time mean minus median AUC	1.2	1.6	2.1	1.0	-1.3	1.2	-1.5
Reaction time num false alarms	1.0	1.3	4.7	0.2	0.3	-0.6	2.2
Reaction time num false alarms AUC	0.8	1.1	3.6	0.8	-0.5	-0.1	1.9
Reaction time trials correct on left	0.2	0.3	0.6	0.8	-0.6	0.7	0.1
Reaction time trials on left	0.3	0.4	0.7	0.8	-0.6	0.8	0.1
Reaction time mean	0.3	0.5	1.3	-0.4	0.2	0.6	-1.2
Reaction time mean AUC	0.4	0.6	1.6	-0.5	0.3	0.5	-1.3
Median of all reaction times	0.3	0.4	0.7	-0.7	0.6	0.3	-0.8
Reaction time omissions	0.6	0.9	1.4	0.9	-0.9	1.2	-0.6
Reaction time false alarm rate	0.6	0.9	2.9	0.2	0.1	-0.7	1.7
Reaction time premature initiation rate	3.3	4.4	6.9	2.6	-2.5	1.6	1.4
Reaction time premature initiations	4.5	6.3	9.6	3.1	-2.9	2.3	1.4
Std. dev. reaction times	0.7	1.0	2.4	0.4	-0.6	1.0	-1.5
Reaction time trials completed	0.3	0.4	0.7	0.8	-0.6	0.8	0.1
Reaction time trials AUC	0.2	0.3	0.5	0.7	-0.5	0.5	0.3
Run reversals in cocaine runway, females	1.2	1.2	1.4	1.2	-1.0	-1.1	1.0
Run reversals in cocaine runway, males	0.2	0.2	0.6	-0.2	0.0	0.4	0.8
Latency to leave start box in cocaine runway	0.4	0.4	1.0	-0.3	0.4	-1.0	-0.7
Latency to leave start box in cocaine runway, F	0.1	0.1	0.2	-0.1	0.1	-0.0	-0.5
Latency to leave start box in cocaine runway, M	0.5	0.5	1.4	-0.2	0.4	-1.2	-0.5
Std. dev. time between licks in bursts	0.8	1.0	3.4	0.6	-0.4	-0.3	1.8
Total sessions with >9 infusions	2.4	2.6	6.2	-1.4	1.5	-2.5	0.3
Short access day 1 total inactive lever presses	3.2	3.5	5.4	-2.2	2.3	-1.8	0.7
Short access day 10 total inactive lever presses	2.4	2.7	3.9	-1.6	1.8	-1.1	2.0
Short access day 1 total infusions	3.2	3.4	6.8	-1.9	1.8	-2.6	-0.0
Short access day 10 total infusions	3.4	3.8	9.3	-1.6	1.6	-3.0	-0.8
Short access total infusions	2.3	2.6	7.0	-1.3	1.4	-2.6	-0.2
Short access day 1 locomotion	2.7	2.9	6.8	-1.5	1.5	-2.6	0.4
Short access day 10 total locomotion	1.9	2.1	4.8	-1.4	1.3	-2.2	0.2
Short access total locomotion	2.0	2.0	4.9	-1.2	1.3	-2.2	0.4
One hour access (0.3 mA shock)	8.1	9.5	15.5	-3.9	3.9	-2.7	-0.0
Compulsive drug intake	4.5	4.5	5.7	2.4	-2.1	2.2	1.8
One hour access (shock baseline)	9.4	10.9	18.3	-4.3	4.0	-2.7	-1.6
Social response proportion	0.7	0.7	0.9	0.7	-1.0	0.7	-0.9
Social responses	0.3	0.4	0.8	0.7	-0.9	0.6	0.0
Social time	0.5	0.7	1.2	0.9	-1.1	0.8	0.3
Soleus weight	2.5	7.2	10.7	-3.2	3.3	-2.6	1.0
Bone: stiffness	1.6	2.5	6.8	1.2	-1.3	0.2	-2.6
Tibialis anterior weight	6.5	22.1	35.0	5.8	-5.9	3.7	-2.5
Time to tail flick, vehicle, before self-admin	0.6	0.6	1.2	0.6	-0.8	-0.3	-1.1
Time to tail flick, vehicle, after self-admin	1.8	2.0	4.4	1.8	-2.1	-0.5	0.0
Time to tail flick, test, before self-admin	1.2	1.2	4.0	-0.5	0.5	-2.0	0.5
Time to tail flick, test, after self-admin	0.1	0.1	0.1	0.2	-0.4	0.2	0.0
Delta time to tail flick, vehicle, before/after SA	0.6	0.6	1.2	1.1	-1.1	-0.2	0.5
Delta time to tail flick, test, before/after SA	2.2	2.0	6.4	0.9	-0.9	2.5	-0.3
Tibia length	1.1	3.0	9.7	0.5	-0.7	1.3	-3.1
Ambulatory time before self-admin	1.0	1.0	3.7	-0.1	-0.0	0.5	-1.9
Ambulatory time after self-admin	0.5	0.6	1.1	-0.9	0.7	-0.0	-1.0
Bone: tissue strength	0.2	0.2	0.6	-0.3	0.4	0.0	-0.8
Total heroin consumption	3.7	4.3	6.5	2.4	-2.6	1.9	-1.1
Bone: trabecular number	0.7	1.1	3.8	0.1	-0.3	-0.5	-2.0
Bone: trabecular spacing	0.5	0.7	2.6	0.1	0.1	0.1	1.6
Bone: trabecular thickness	0.7	0.8	1.1	-1.0	1.0	-0.9	-0.5
Bone: trabecular tissue density	2.0	2.9	5.2	-2.3	2.3	-1.0	0.5
Water consumed over 24 hours	1.2	1.4	3.0	1.1	-1.2	1.7	0.5
Number of responses in last shaping day	0.8	0.9	1.6	-0.9	0.9	-0.4	1.3