Hub : Genes

Nudt8

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Liver gene expression Nudt8 0.08 0.07 2.8e-04 0.03 0.03 0.03 0.02 6.9e-04 3.4e-04 6.7e-04 3.1e-03
2 Adipose gene expression Nudt8 0.04 0.03 1.3e-03 0.01 0.01 0 0.01 1.2e-02 1.4e-02 2.3e-01 4.7e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bone: apparent density0.71.41.90.9-1.4
Area under the delay curve0.50.70.80.8-0.9
BMI with tail0.00.20.30.0-0.6
BMI without tail0.10.60.8-0.90.6
Body weight1.04.35.6-2.41.7
Weight adjusted by age0.41.21.4-1.21.0
Bone surface0.10.10.2-0.1-0.5
Bone volume0.40.71.10.6-1.0
Breakpoint value in progressive ratio session0.91.61.6-1.31.2
Number of licking bursts0.00.00.10.2-0.2
Context. condit. distance diff. score1.11.31.41.1-1.2
Locomotion velocity, session 10.00.00.00.0-0.0
Locomotion distance, session 10.30.40.50.5-0.7
Locomotion velocity, session 21.41.71.9-1.41.2
Locomotion distance, session 20.10.10.2-0.40.2
Locomotion velocity, session 31.01.11.21.0-1.1
Locomotion distance, session 30.10.10.10.3-0.3
Stereotopy head waving bouts, day 31.51.71.81.3-1.4
Stereotopy head waving duration, day 31.72.12.21.5-1.4
Locomotion velocity, session 70.60.60.80.7-0.9
Locomotion distance, session 70.00.00.1-0.30.1
Stereotopy head waving bouts, day 71.51.81.91.3-1.4
Stereotopy head waving duration, day 70.30.30.50.4-0.7
Locomotion velocity, session 80.80.91.2-1.10.8
Locomotion distance, session 80.60.80.90.8-1.0
Degree of sensitization distance0.00.00.0-0.1-0.1
Degree of sensitization stereotypy0.20.20.30.3-0.5
Conditioned locomotion4.75.55.6-2.32.4
Cocaine response after cond. corrected0.10.10.20.4-0.4
Cocaine response after cond. not corrected0.30.40.50.7-0.7
Cocaine response before conditioning0.00.00.00.2-0.2
Saline control response1.52.12.4-1.61.3
Bone: connectivity density0.10.20.30.0-0.6
Bone: cortical apparent density0.61.01.0-1.01.0
Bone: cortical area0.91.51.5-1.21.2
Bone: cortical porosity0.00.00.00.1-0.0
Bone: cortical porosity0.10.20.2-0.40.4
Bone: cortical thickness7.212.112.2-3.53.5
Bone: cortical thickness2.42.93.0-1.71.7
Bone: cortical tissue density0.81.31.3-1.21.1
Condit. Reinf. active minus inactive responses0.10.10.10.2-0.4
Condit. Reinf. active-inactive response ratio0.20.20.30.5-0.5
Condit. Reinf. active responses0.00.00.00.1-0.2
Condit. Reinf. inactive responses0.00.00.00.10.0
Incentive salience index mean0.00.00.00.1-0.2
Condit. Reinf. lever presses0.00.10.1-0.30.2
Condit. Reinf. active minus inactive responses1.42.12.21.4-1.5
Condit. Reinf. active-inactive response ratio1.93.03.11.8-1.7
Condit. Reinf. active responses1.11.51.81.1-1.3
Condit. Reinf. inactive responses0.00.00.0-0.2-0.1
Condit. Reinf. lever presses0.00.10.10.1-0.3
Condit. Reinf. lever reinforcers received0.81.21.41.0-1.2
Conditioned reinforcement - actives0.00.10.2-0.30.5
Conditioned reinforcement - inactives1.13.13.61.9-1.6
Conditioned locomotion3.24.85.92.4-1.9
Patch foraging indifference point 0 sec0.20.50.50.7-0.7
Patch foraging indifference point AUC0.81.91.9-1.41.4
Delay disc. indifference point, 0s delay1.61.82.01.3-1.4
Delay disc. indifference point, 16s delay1.01.51.61.3-1.2
Delay disc. indifference point, 2s delay1.31.41.51.2-1.2
Delay disc. indifference point, 24s delay0.30.50.6-0.50.8
Delay disc. indifference point, 4s delay0.30.30.40.4-0.6
Delay disc. indifference point, 8s delay0.10.10.10.4-0.3
Indifference point function ln k1.02.93.51.9-1.5
Indifference point function log k1.02.93.51.9-1.5
Patch foraging total patch changes 0 sec0.00.00.00.1-0.0
Patch foraging total patch changes 12 sec1.52.12.3-1.51.4
Patch foraging total patch changes 18 sec0.00.00.0-0.20.1
Patch foraging total patch changes 24 sec0.41.31.3-1.21.1
Patch foraging total patch changes 6 sec0.00.10.1-0.30.2
Patch foraging time to switch 0 sec0.10.30.50.3-0.7
Patch foraging water rate 0 sec0.00.10.20.40.1
Patch foraging water rate 12 sec0.10.40.70.9-0.3
Patch foraging water rate 18 sec0.10.20.30.6-0.4
Patch foraging water rate 24 sec0.10.10.2-0.00.4
Patch foraging water rate 6 sec0.10.20.3-0.20.5
Seeking ratio, delayed vs. immediate footshock0.40.60.70.7-0.9
Distance traveled before self-admin0.10.20.20.4-0.5
Distance traveled after self-admin0.00.00.00.1-0.1
Extensor digitorum longus weight5.923.626.1-5.14.6
Bone: elastic displacement1.62.02.2-1.31.5
Bone: elastic work3.44.54.6-2.12.1
Bone: endosteal estimation2.35.55.62.4-2.3
Bone: endosteal perimeter4.611.211.33.4-3.3
Epididymis fat weight1.78.610.23.2-2.7
Delta time in closed arm before/after self-admin1.81.71.8-1.31.2
Delta time in open arm before/after self-admin0.20.20.20.5-0.5
Diff in mean of infusions in LGA sessions0.51.01.0-1.01.0
Delay discount exponential model param0.30.40.5-0.60.7
Extinction: sum of active levers before priming0.20.30.5-0.70.5
Active lever presses in extinction session 61.81.81.9-1.31.4
Bone: final force0.40.70.8-0.90.7
Bone: final moment0.40.70.9-0.90.7
Food consumed during 24 hour testing period0.00.00.00.20.0
Glucose4.67.37.52.7-2.7
Heart weight1.82.93.11.7-1.8
Delay discount hyperbolic model param0.50.60.7-0.70.8
Intermittent access intake day 1-15 change0.42.22.51.6-1.4
Intermittent access intake escalation0.31.71.91.4-1.2
Intermittent access intake escalation 21.01.71.81.3-1.2
Intermitt. access day 1 inactive lever presses0.00.00.00.10.1
Intermitt. access day 15 inactive lever presses0.63.33.61.9-1.7
Intermitt. access escalation Index0.20.60.80.9-0.7
Intermittent access day 1 total infusions2.36.86.92.6-2.6
Intermittent access day 15 total infusions3.48.29.13.0-2.7
Intermittent access terminal intake (last 3 days)4.98.69.23.0-2.8
Intermittent access total infusions5.05.96.32.5-2.4
Intermittent access day 1 locomotion1.62.93.11.7-1.6
Intermittent access day 15 total locomotion2.18.08.42.9-2.8
Intermittent access total locomotion9.711.712.33.5-3.3
Intermittent access standard deviation0.31.41.51.2-1.1
Left kidney weight0.53.74.22.1-1.8
Right kidney weight0.21.11.41.2-0.9
Cocaine induced anxiety0.00.10.10.3-0.3
Post-drug Anxiety0.10.10.1-0.40.3
Baseline Anxiety0.40.70.7-0.90.8
Tail length1.15.96.1-2.42.5
Length with tail2.611.512.6-3.53.2
Length without tail1.36.77.7-2.82.4
Times rat made contact with spout0.00.00.0-0.1-0.1
Lifetime Intake2.83.43.61.9-1.8
Liver weight, left0.00.00.00.10.2
Liver weight, right0.20.30.50.7-0.4
Locomotor activity0.00.10.10.3-0.2
Locomotor testing distance0.00.10.20.4-0.1
Locomotor testing rearing0.41.41.41.2-1.1
Locomotion in novel chamber5.47.28.02.8-2.5
Locomotion in novel chamber post-restriction1.23.54.02.0-1.7
Fecal boli incidents, locomotor time 10.00.00.00.1-0.2
Change in fecal boli incidents, locomotor task0.00.00.0-0.10.1
Time >=10cm from walls, locomotor time 14.05.05.52.1-2.3
Bouts of movement, locomotor time 11.52.02.1-1.51.3
Total resting periods, locomotor time 10.91.11.2-1.11.0
Rest time, locomotor task time 10.20.30.50.7-0.5
Distance moved, locomotor task time 10.20.40.50.6-0.7
Vertical activity count, locomotor time 10.21.61.81.3-1.2
Time >=10cm from walls, locomotor time 20.00.00.0-0.0-0.0
Bouts of movement, locomotor time 20.20.60.6-0.70.8
Total resting periods, locomotor time 20.00.10.1-0.30.4
Rest time, locomotor task time 22.03.43.71.9-1.8
Distance moved, locomotor task time 21.52.02.1-1.51.4
Vertical activity count, locomotor time 21.02.42.5-1.51.6
Light reinforcement 10.10.30.30.6-0.4
Light reinforcement 20.40.91.11.1-0.8
Bone: marrow area2.35.75.82.4-2.4
Bone: maximum diameter0.00.00.10.2-0.1
Bone: maximum force0.00.00.1-0.1-0.3
Bone: maximum moment0.00.00.0-0.2-0.2
Mean time between licks in bursts0.10.50.6-0.80.7
Mean num. licks in bursts0.00.00.00.0-0.2
Cd content in liver1.61.81.91.4-1.3
Co content in liver0.60.70.9-0.61.0
Cu content in liver0.00.00.00.10.0
Fe content in liver0.20.20.2-0.40.5
K content in liver0.00.00.0-0.1-0.0
Mg content in liver0.70.80.80.9-0.8
Mn content in liver1.41.51.7-1.31.2
Na content in liver0.40.50.6-0.60.8
Rb content in liver2.12.42.61.6-1.5
Se content in liver0.70.90.90.9-1.0
Sr content in liver3.22.82.9-1.71.6
Zn content in liver0.70.80.8-0.90.9
Bone: minimum diameter2.54.85.12.2-2.2
Time in familiar zone, hab. session 10.70.80.80.9-0.9
Time in novel zone, hab. session 10.10.10.1-0.30.4
Total zone transitions, hab. session 10.10.10.2-0.40.3
Total locomotion distance, hab. session 10.50.70.80.9-0.8
Locomotion velocity, hab. session 10.10.20.20.4-0.4
Time in familiar zone, hab. session 21.11.31.3-1.21.1
Time in novel zone, hab. session 20.91.01.11.0-1.0
Total zone transitions, hab. session 20.50.71.00.6-1.0
Total locomotion distance, hab. session 20.91.11.21.0-1.1
Locomotion velocity, hab. session 21.21.61.71.2-1.3
Novel to familiar place preference ratio0.10.10.20.3-0.4
Novelty place preference0.30.40.40.6-0.7
Time in novel zone, NPP test0.30.40.40.6-0.7
Total zone transitions, NPP test0.00.00.0-0.2-0.2
Total locomotion distance, NPP test0.30.40.50.6-0.7
Locomotion velocity, NPP test0.20.30.30.5-0.6
Intraocular pressure0.10.10.2-0.20.5
Delta distance traveled before/after self-admin0.20.20.2-0.40.4
Delta ambulatory time before/after self-admin0.20.40.5-0.60.7
Parametrial fat weight3.27.47.72.8-2.7
Pavlov. Cond. lever latency0.10.10.10.3-0.2
Pavlov. Cond. magazine entry latency0.81.11.20.9-1.1
Pavlov. Cond. change in total contacts0.91.01.11.0-1.1
Pavlov. Cond. index score0.10.10.10.2-0.4
Pavlov. Cond. latency score0.10.10.20.3-0.4
Pavlov. Cond. lever contacts0.00.00.0-0.0-0.1
Pavlov. Cond. magazine entry number0.10.10.1-0.30.3
Pavlov. Cond. intertrial magazine entries0.10.20.2-0.30.5
Pavlov. Cond. lever-magazine prob. diff.0.10.10.10.2-0.4
Pavlov. Cond. response bias0.00.00.00.1-0.2
Pavlov. Cond. lever latency0.00.00.00.1-0.1
Pavlov. Cond. magazine entry latency0.20.30.5-0.70.3
Pavlov. Cond. change in total contacts0.10.30.30.4-0.6
Pavlov. Cond. index score0.00.00.0-0.2-0.0
Pavlov. Cond. latency score0.00.00.0-0.2-0.0
Pavlov. Cond. lever contacts0.00.00.0-0.10.0
Pavlov. Cond. magazine entry number0.40.50.80.9-0.5
Pavlov. Cond. intertrial magazine entries0.30.60.80.9-0.7
Pavlov. Cond. lever-magazine prob. diff.0.00.10.1-0.30.1
Pavlov. Cond. response bias0.00.00.0-0.2-0.0
Time in closed arm before self-admin1.11.92.11.4-1.3
Time in closed arm after self-admin0.00.00.00.00.1
Time in open arm before self-admin1.51.81.8-1.41.3
Time in open arm after self-admin0.20.20.3-0.50.3
Bone: periosteal estimation0.20.40.40.7-0.6
Bone: periosteal perimeter0.51.01.11.0-1.0
Bone: post-yield work5.39.210.42.8-3.2
Progressive ratio test 1 active lever presses0.00.00.0-0.00.2
Progressive ratio test 1 breakpoint0.00.00.1-0.10.2
Progressive ratio test 1 inactive lever presses0.00.00.00.10.1
Progressive ratio test 2 active lever presses1.42.02.31.5-1.3
Progressive ratio test 2 breakpoint1.41.82.01.4-1.2
Progressive ratio test 2 inactive lever presses2.88.89.83.1-2.8
Incentive Sensitization - Responses0.20.50.60.6-0.8
Incentive Sensitization - Breakpoint0.30.80.90.8-0.9
Sum of active levers in priming session hrs 5-62.62.42.8-1.41.7
Progressive ratio0.31.01.40.8-1.2
Food seeking constrained by brief footshock0.00.00.0-0.10.0
Seeking ratio, punishment vs. effort0.10.30.4-0.30.7
Retroperitoneal fat weight5.424.227.75.3-4.6
Reaction time number correct0.41.51.6-1.31.2
Reaction time mean minus median0.10.81.0-1.00.8
Reaction time mean minus median AUC0.31.71.9-1.41.2
Reaction time num false alarms0.61.11.3-1.01.1
Reaction time num false alarms AUC0.92.02.1-1.41.4
Reaction time trials correct on left0.41.51.6-1.31.2
Reaction time trials on left0.61.92.0-1.41.3
Reaction time mean0.10.30.30.6-0.4
Reaction time mean AUC0.20.50.50.7-0.6
Median of all reaction times0.71.01.21.1-0.9
Reaction time omissions1.32.02.4-1.61.3
Reaction time false alarm rate0.30.50.6-0.60.8
Reaction time premature initiation rate2.03.03.2-1.81.7
Reaction time premature initiations2.36.97.1-2.72.6
Std. dev. reaction times0.00.10.1-0.40.3
Reaction time trials completed0.61.92.0-1.41.3
Reaction time trials AUC0.41.41.5-1.21.1
Run reversals in cocaine runway, females0.00.00.0-0.0-0.2
Run reversals in cocaine runway, males0.80.91.0-0.81.0
Latency to leave start box in cocaine runway1.21.71.91.2-1.4
Latency to leave start box in cocaine runway, F0.91.11.31.0-1.1
Latency to leave start box in cocaine runway, M0.00.00.00.2-0.2
Std. dev. time between licks in bursts1.42.62.7-1.61.7
Total sessions with >9 infusions0.00.00.00.0-0.1
Short access day 1 total inactive lever presses0.71.41.71.3-1.0
Short access day 10 total inactive lever presses0.00.00.00.2-0.0
Short access day 1 total infusions0.71.41.61.3-1.1
Short access day 10 total infusions1.22.02.11.4-1.5
Short access total infusions0.50.70.70.8-0.8
Short access day 1 locomotion0.71.21.31.2-1.0
Short access day 10 total locomotion0.41.71.71.3-1.3
Short access total locomotion1.01.61.71.3-1.2
One hour access (0.3 mA shock)4.45.25.92.4-2.1
Compulsive drug intake3.95.75.7-2.42.4
One hour access (shock baseline)3.28.39.43.1-2.7
Social response proportion0.00.00.1-0.3-0.0
Social responses0.70.91.1-1.10.8
Social time0.30.50.6-0.80.5
Soleus weight1.03.03.92.0-1.4
Bone: stiffness0.20.30.50.3-0.7
Tibialis anterior weight10.436.037.8-6.15.8
Time to tail flick, vehicle, before self-admin0.50.60.70.7-0.8
Time to tail flick, vehicle, after self-admin0.00.00.0-0.2-0.1
Time to tail flick, test, before self-admin2.83.23.71.6-1.9
Time to tail flick, test, after self-admin0.00.00.0-0.20.1
Delta time to tail flick, vehicle, before/after SA0.20.20.4-0.60.3
Delta time to tail flick, test, before/after SA4.25.25.9-2.12.4
Tibia length0.82.12.3-1.41.5
Ambulatory time before self-admin0.20.50.60.6-0.8
Ambulatory time after self-admin1.21.91.91.4-1.4
Bone: tissue strength0.40.40.50.6-0.7
Total heroin consumption3.03.53.8-2.01.8
Bone: trabecular number0.61.11.50.8-1.2
Bone: trabecular spacing0.10.10.2-0.20.4
Bone: trabecular thickness1.62.22.51.4-1.6
Bone: trabecular tissue density1.01.82.51.6-1.1
Water consumed over 24 hours0.10.10.2-0.40.3
Number of responses in last shaping day0.20.30.3-0.50.5