Hub : Genes

Nudt8

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Liver gene expression Nudt8 0.08 0.07 1.6e-04 0.02 0.03 0.03 0.02 3.2e-03 2.8e-04 3.8e-04 3.6e-03
2 Adipose gene expression Nudt8 0.04 0.03 1.0e-03 0.02 0.01 0 0.01 4.3e-03 1.2e-02 9.0e-02 9.6e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bone: apparent density1.11.92.41.2-1.5
Area under the delay curve1.01.11.40.9-1.2
BMI with tail0.00.00.1-0.2-0.1
BMI without tail0.00.00.0-0.2-0.1
Body weight1.56.27.3-2.72.2
Weight adjusted by age1.41.61.9-1.21.4
Bone surface0.10.10.30.1-0.5
Bone volume0.61.01.30.9-1.2
Breakpoint value in progressive ratio session1.11.21.3-1.11.0
Number of licking bursts0.00.00.00.2-0.1
Context. condit. distance diff. score1.01.31.41.2-1.1
Locomotion velocity, session 10.00.00.00.00.1
Locomotion distance, session 10.30.30.40.5-0.6
Locomotion velocity, session 21.71.92.1-1.41.3
Locomotion distance, session 20.10.10.1-0.30.3
Locomotion velocity, session 30.91.11.11.0-1.1
Locomotion distance, session 30.00.00.10.2-0.2
Stereotopy head waving bouts, day 31.92.22.41.4-1.5
Stereotopy head waving duration, day 32.12.52.51.6-1.6
Locomotion velocity, session 70.70.80.80.9-0.9
Locomotion distance, session 70.00.00.0-0.20.1
Stereotopy head waving bouts, day 72.02.32.31.5-1.5
Stereotopy head waving duration, day 70.30.40.50.5-0.7
Locomotion velocity, session 80.81.01.1-1.00.9
Locomotion distance, session 80.40.60.70.8-0.7
Degree of sensitization distance0.00.00.0-0.0-0.1
Degree of sensitization stereotypy0.20.20.30.4-0.5
Conditioned locomotion5.05.85.8-2.42.4
Cocaine response after cond. corrected0.20.20.20.5-0.5
Cocaine response after cond. not corrected0.60.60.60.8-0.8
Cocaine response before conditioning0.00.00.00.1-0.2
Saline control response1.41.82.1-1.41.2
Bone: connectivity density0.20.30.50.3-0.7
Bone: cortical apparent density0.71.01.0-1.01.0
Bone: cortical area0.91.41.4-1.21.1
Bone: cortical porosity0.10.10.10.2-0.3
Bone: cortical porosity0.10.10.2-0.40.3
Bone: cortical thickness6.711.011.3-3.43.3
Bone: cortical thickness2.83.23.4-1.91.7
Bone: cortical tissue density0.91.21.2-1.11.1
Condit. Reinf. active minus inactive responses0.10.10.10.4-0.3
Condit. Reinf. active-inactive response ratio0.20.30.30.5-0.5
Condit. Reinf. active responses0.00.00.00.2-0.1
Condit. Reinf. inactive responses0.00.00.0-0.10.1
Incentive salience index mean0.00.00.00.1-0.1
Condit. Reinf. lever presses0.10.20.2-0.30.4
Condit. Reinf. active minus inactive responses2.12.62.71.6-1.6
Condit. Reinf. active-inactive response ratio2.83.03.11.8-1.7
Condit. Reinf. active responses1.42.02.11.3-1.5
Condit. Reinf. inactive responses0.00.00.10.0-0.2
Condit. Reinf. lever presses0.00.00.00.0-0.2
Condit. Reinf. lever reinforcers received1.11.51.71.2-1.3
Conditioned reinforcement - actives0.00.00.0-0.1-0.1
Conditioned reinforcement - inactives4.24.85.22.1-2.3
Conditioned locomotion1.92.32.91.7-1.3
Patch foraging indifference point 0 sec0.40.70.70.8-0.8
Patch foraging indifference point AUC2.02.32.3-1.51.5
Delay disc. indifference point, 0s delay1.92.12.81.2-1.7
Delay disc. indifference point, 16s delay1.51.61.81.3-1.2
Delay disc. indifference point, 2s delay1.01.11.11.0-1.1
Delay disc. indifference point, 24s delay0.20.20.3-0.50.3
Delay disc. indifference point, 4s delay0.20.20.20.4-0.4
Delay disc. indifference point, 8s delay0.30.30.40.4-0.6
Indifference point function ln k2.53.53.81.9-1.8
Indifference point function log k2.53.53.81.9-1.8
Patch foraging total patch changes 0 sec0.00.10.10.2-0.3
Patch foraging total patch changes 12 sec1.41.82.1-1.51.2
Patch foraging total patch changes 18 sec0.00.00.0-0.20.1
Patch foraging total patch changes 24 sec1.11.31.5-1.21.1
Patch foraging total patch changes 6 sec0.00.00.0-0.2-0.0
Patch foraging time to switch 0 sec0.10.20.30.4-0.5
Patch foraging water rate 0 sec0.00.00.10.30.0
Patch foraging water rate 12 sec0.10.20.40.6-0.2
Patch foraging water rate 18 sec0.20.30.30.6-0.5
Patch foraging water rate 24 sec0.00.00.1-0.10.2
Patch foraging water rate 6 sec0.10.10.2-0.30.4
Seeking ratio, delayed vs. immediate footshock0.30.30.30.6-0.6
Distance traveled before self-admin0.00.00.00.00.1
Distance traveled after self-admin0.00.00.10.20.3
Extensor digitorum longus weight5.220.522.2-4.74.3
Bone: elastic displacement1.31.51.5-1.21.2
Bone: elastic work3.14.04.2-2.01.9
Bone: endosteal estimation2.65.75.72.4-2.4
Bone: endosteal perimeter5.511.411.53.4-3.4
Epididymis fat weight2.25.05.62.4-2.1
Delta time in closed arm before/after self-admin0.90.91.5-1.20.5
Delta time in open arm before/after self-admin0.20.20.30.5-0.3
Diff in mean of infusions in LGA sessions0.40.40.5-0.70.6
Delay discount exponential model param0.70.71.0-0.71.0
Extinction: sum of active levers before priming1.41.31.5-1.11.2
Active lever presses in extinction session 62.72.73.0-1.71.5
Bone: final force0.40.70.9-1.00.7
Bone: final moment0.40.70.8-0.90.7
Food consumed during 24 hour testing period0.00.00.00.1-0.0
Glucose3.45.15.52.3-2.2
Heart weight1.52.12.41.5-1.4
Delay discount hyperbolic model param0.70.70.9-0.71.0
Intermittent access intake day 1-15 change0.30.30.40.6-0.5
Intermittent access intake escalation0.70.70.90.9-0.8
Intermittent access intake escalation 20.10.10.20.40.0
Intermitt. access day 1 inactive lever presses0.90.91.41.2-0.7
Intermitt. access day 15 inactive lever presses2.42.62.81.7-1.5
Intermitt. access escalation Index0.90.80.91.0-0.8
Intermittent access day 1 total infusions8.09.39.43.1-3.0
Intermittent access day 15 total infusions8.08.99.63.1-2.9
Intermittent access terminal intake (last 3 days)7.27.98.22.9-2.8
Intermittent access total infusions5.56.16.42.5-2.4
Intermittent access day 1 locomotion3.73.94.32.1-1.9
Intermittent access day 15 total locomotion4.75.15.12.3-2.3
Intermittent access total locomotion8.69.810.23.2-3.1
Intermittent access standard deviation0.70.70.90.7-1.0
Left kidney weight0.10.40.50.7-0.5
Right kidney weight0.00.00.00.10.1
Cocaine induced anxiety0.10.10.30.1-0.5
Post-drug Anxiety1.21.31.8-1.40.9
Baseline Anxiety2.83.03.3-1.71.8
Tail length1.54.65.0-2.22.0
Length with tail2.910.511.4-3.43.1
Length without tail2.24.95.2-2.32.1
Times rat made contact with spout0.00.00.00.0-0.2
Lifetime Intake4.75.35.42.3-2.3
Liver weight, left0.10.10.20.3-0.4
Liver weight, right0.10.10.1-0.40.3
Locomotor activity0.10.10.10.3-0.3
Locomotor testing distance0.20.30.30.4-0.6
Locomotor testing rearing1.21.92.01.3-1.4
Locomotion in novel chamber5.77.17.52.7-2.6
Locomotion in novel chamber post-restriction2.93.54.61.6-2.1
Fecal boli incidents, locomotor time 10.10.10.10.2-0.4
Change in fecal boli incidents, locomotor task0.00.00.1-0.2-0.2
Time >=10cm from walls, locomotor time 15.55.56.42.1-2.5
Bouts of movement, locomotor time 11.01.11.7-1.30.7
Total resting periods, locomotor time 10.60.71.0-1.00.6
Rest time, locomotor task time 10.10.10.10.3-0.4
Distance moved, locomotor task time 10.30.30.50.7-0.3
Vertical activity count, locomotor time 11.41.41.91.4-1.0
Time >=10cm from walls, locomotor time 20.10.10.20.00.5
Bouts of movement, locomotor time 20.70.70.8-0.80.9
Total resting periods, locomotor time 20.20.20.2-0.40.5
Rest time, locomotor task time 24.24.86.01.9-2.4
Distance moved, locomotor task time 22.22.53.4-1.31.8
Vertical activity count, locomotor time 23.03.34.4-1.52.1
Light reinforcement 10.10.20.30.5-0.3
Light reinforcement 20.70.91.21.1-0.8
Bone: marrow area2.65.75.72.4-2.4
Bone: maximum diameter0.00.00.00.1-0.1
Bone: maximum force0.00.10.10.0-0.4
Bone: maximum moment0.00.00.1-0.0-0.3
Mean time between licks in bursts0.71.01.1-1.10.9
Mean num. licks in bursts0.00.10.10.1-0.3
Cd content in liver0.40.50.60.8-0.6
Co content in liver0.30.30.4-0.50.6
Cu content in liver0.20.30.3-0.50.5
Fe content in liver0.00.00.0-0.20.2
K content in liver0.00.00.00.0-0.2
Mg content in liver2.22.22.41.4-1.6
Mn content in liver0.60.70.8-0.90.8
Na content in liver0.30.30.3-0.60.6
Rb content in liver3.94.84.92.2-2.2
Se content in liver1.01.21.21.1-1.1
Sr content in liver3.53.23.3-1.81.8
Zn content in liver0.70.80.9-0.90.8
Bone: minimum diameter2.95.35.62.3-2.4
Time in familiar zone, hab. session 10.80.70.80.9-0.8
Time in novel zone, hab. session 10.10.10.1-0.30.3
Total zone transitions, hab. session 10.10.10.1-0.40.3
Total locomotion distance, hab. session 10.50.70.80.9-0.8
Locomotion velocity, hab. session 10.10.20.20.4-0.4
Time in familiar zone, hab. session 21.41.41.5-1.21.2
Time in novel zone, hab. session 21.21.21.21.1-1.1
Total zone transitions, hab. session 20.50.60.80.7-0.9
Total locomotion distance, hab. session 20.91.21.21.1-1.1
Locomotion velocity, hab. session 21.21.61.71.3-1.3
Novel to familiar place preference ratio0.10.10.10.3-0.4
Novelty place preference0.40.40.40.6-0.6
Time in novel zone, NPP test0.40.40.40.6-0.6
Total zone transitions, NPP test0.00.00.0-0.20.1
Total locomotion distance, NPP test0.20.30.40.6-0.5
Locomotion velocity, NPP test0.20.20.20.5-0.4
Intraocular pressure0.10.20.2-0.30.4
Delta distance traveled before/after self-admin0.00.00.0-0.00.1
Delta ambulatory time before/after self-admin0.20.20.3-0.30.5
Parametrial fat weight2.44.75.12.3-2.1
Pavlov. Cond. lever latency0.00.00.00.2-0.1
Pavlov. Cond. magazine entry latency1.01.31.31.1-1.2
Pavlov. Cond. change in total contacts0.91.01.01.0-1.0
Pavlov. Cond. index score0.10.10.10.3-0.2
Pavlov. Cond. latency score0.10.10.10.4-0.3
Pavlov. Cond. lever contacts0.00.00.00.1-0.0
Pavlov. Cond. magazine entry number0.00.00.0-0.20.1
Pavlov. Cond. intertrial magazine entries0.10.10.1-0.30.4
Pavlov. Cond. lever-magazine prob. diff.0.00.00.00.2-0.1
Pavlov. Cond. response bias0.00.10.10.3-0.2
Pavlov. Cond. lever latency0.00.00.00.00.1
Pavlov. Cond. magazine entry latency0.20.20.3-0.60.3
Pavlov. Cond. change in total contacts0.20.20.30.4-0.6
Pavlov. Cond. index score0.00.00.0-0.2-0.0
Pavlov. Cond. latency score0.00.00.0-0.1-0.1
Pavlov. Cond. lever contacts0.10.10.1-0.30.3
Pavlov. Cond. magazine entry number0.30.30.50.7-0.4
Pavlov. Cond. intertrial magazine entries0.50.60.80.9-0.7
Pavlov. Cond. lever-magazine prob. diff.0.00.10.1-0.30.1
Pavlov. Cond. response bias0.10.10.1-0.40.2
Time in closed arm before self-admin0.20.20.50.7-0.2
Time in closed arm after self-admin0.10.10.2-0.50.0
Time in open arm before self-admin0.40.40.5-0.70.5
Time in open arm after self-admin0.10.10.1-0.20.4
Bone: periosteal estimation0.20.40.40.6-0.7
Bone: periosteal perimeter0.50.91.00.9-1.0
Bone: post-yield work6.99.410.12.9-3.2
Progressive ratio test 1 active lever presses0.80.90.90.9-0.9
Progressive ratio test 1 breakpoint0.50.50.60.8-0.7
Progressive ratio test 1 inactive lever presses0.30.30.50.7-0.4
Progressive ratio test 2 active lever presses2.52.72.91.6-1.7
Progressive ratio test 2 breakpoint2.02.32.41.5-1.5
Progressive ratio test 2 inactive lever presses6.87.89.03.0-2.6
Incentive Sensitization - Responses0.50.50.80.6-0.9
Incentive Sensitization - Breakpoint0.70.70.90.7-0.9
Sum of active levers in priming session hrs 5-63.23.13.4-1.61.8
Progressive ratio0.20.20.30.4-0.5
Food seeking constrained by brief footshock0.40.50.8-0.40.9
Seeking ratio, punishment vs. effort0.30.40.7-0.30.9
Retroperitoneal fat weight3.611.913.13.6-3.3
Reaction time number correct1.21.71.7-1.31.3
Reaction time mean minus median0.30.40.6-0.80.5
Reaction time mean minus median AUC1.01.31.5-1.21.0
Reaction time num false alarms0.70.91.0-0.91.0
Reaction time num false alarms AUC1.21.71.7-1.31.3
Reaction time trials correct on left1.21.71.7-1.31.3
Reaction time trials on left1.42.12.1-1.41.4
Reaction time mean0.30.40.40.6-0.6
Reaction time mean AUC0.40.50.50.7-0.7
Median of all reaction times0.70.91.01.0-0.9
Reaction time omissions1.52.02.1-1.51.4
Reaction time false alarm rate0.20.30.3-0.60.6
Reaction time premature initiation rate2.02.62.9-1.71.5
Reaction time premature initiations4.56.46.8-2.62.4
Std. dev. reaction times0.00.00.1-0.30.1
Reaction time trials completed1.42.12.1-1.41.4
Reaction time trials AUC1.01.51.5-1.21.2
Run reversals in cocaine runway, females0.00.00.10.1-0.2
Run reversals in cocaine runway, males1.21.21.3-1.01.1
Latency to leave start box in cocaine runway0.91.01.11.1-0.9
Latency to leave start box in cocaine runway, F0.30.40.60.8-0.4
Latency to leave start box in cocaine runway, M0.10.10.10.2-0.3
Std. dev. time between licks in bursts2.12.52.6-1.61.6
Total sessions with >9 infusions1.01.11.21.0-1.1
Short access day 1 total inactive lever presses1.41.62.61.6-0.8
Short access day 10 total inactive lever presses0.70.81.51.2-0.3
Short access day 1 total infusions2.93.13.82.0-1.5
Short access day 10 total infusions4.65.15.82.1-2.4
Short access total infusions2.32.62.91.5-1.7
Short access day 1 locomotion2.83.03.11.7-1.7
Short access day 10 total locomotion1.41.61.61.2-1.3
Short access total locomotion1.01.11.21.1-1.0
One hour access (0.3 mA shock)5.86.87.62.8-2.4
Compulsive drug intake5.15.25.7-2.42.2
One hour access (shock baseline)6.37.38.93.0-2.4
Social response proportion0.00.10.1-0.30.1
Social responses0.81.01.1-1.01.0
Social time0.40.50.6-0.80.7
Soleus weight1.02.83.41.8-1.5
Bone: stiffness0.20.30.40.4-0.6
Tibialis anterior weight10.536.037.3-6.15.9
Time to tail flick, vehicle, before self-admin1.01.01.40.8-1.2
Time to tail flick, vehicle, after self-admin0.90.91.0-1.00.9
Time to tail flick, test, before self-admin1.41.31.31.2-1.1
Time to tail flick, test, after self-admin0.10.10.1-0.30.2
Delta time to tail flick, vehicle, before/after SA1.11.11.2-1.11.0
Delta time to tail flick, test, before/after SA3.83.43.6-1.91.8
Tibia length0.82.22.3-1.41.5
Ambulatory time before self-admin0.10.10.20.3-0.4
Ambulatory time after self-admin1.51.61.91.4-1.1
Bone: tissue strength0.40.40.40.6-0.6
Total heroin consumption2.52.93.7-1.91.4
Bone: trabecular number0.91.31.71.0-1.3
Bone: trabecular spacing0.20.30.4-0.50.6
Bone: trabecular thickness2.53.03.21.7-1.8
Bone: trabecular tissue density1.01.41.81.4-1.0
Water consumed over 24 hours0.00.00.1-0.30.1
Number of responses in last shaping day0.10.10.10.40.1