Hub : Genes

Kctd9

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 LHb gene expression Kctd9 0.17 0.14 5.2e-03 0.02 0.04 0.04 0.02 1.4e-01 4.9e-02 3.5e-02 1.2e-01
2 NAcc gene expression Kctd9 0.14 0.09 3.4e-14 0.05 0.08 0.08 0.08 3.5e-08 1.6e-12 2.6e-12 9.3e-12
3 PL gene expression Kctd9 0.1 0.07 4.9e-11 0.08 0.09 0.09 0.08 1.8e-09 6.3e-10 7.6e-10 2.4e-09
4 BLA gene expression Kctd9 0.12 0.09 7.6e-05 0.03 0.04 0.03 0.03 1.1e-02 3.1e-03 1.2e-02 1.0e-02
5 IC gene expression Kctd9 0.08 0.07 1.7e-03 0.04 0.06 0.03 0.05 5.5e-03 1.8e-03 2.8e-02 3.9e-03
6 Brain gene expression Kctd9 0.06 0.05 5.0e-06 0.07 0.06 0.06 0.07 3.4e-07 2.7e-06 3.9e-06 7.5e-07
7 pVTA gene expression Kctd9 0.05 0.04 4.7e-04 0.03 0.03 0.01 0.02 1.9e-03 3.9e-03 3.0e-02 4.6e-03
8 Eye alternative polyA XM_063274487.1 0.28 0.19 2.4e-03 0.13 0.12 0.14 0.11 5.6e-03 7.1e-03 4.1e-03 1.0e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8
Bone: apparent density1.42.63.01.5-1.6-1.6-1.6-1.71.71.6-1.4
Area under the delay curve0.10.10.3-0.20.20.30.30.3-0.3-0.30.5
BMI with tail0.31.01.6-1.01.31.11.11.1-0.5-0.90.9
BMI without tail0.00.10.1-0.30.40.20.20.10.30.1-0.4
Body weight0.41.72.4-0.71.31.21.31.5-1.0-1.61.5
Weight adjusted by age0.72.03.0-1.11.21.31.31.4-1.5-1.41.7
Bone surface0.81.72.01.4-1.4-1.4-1.4-1.31.21.2-0.9
Bone volume0.91.82.11.4-1.4-1.4-1.4-1.41.31.2-0.9
Breakpoint value in progressive ratio session0.10.20.3-0.60.50.50.50.4-0.0-0.30.4
Number of licking bursts0.00.00.1-0.40.30.20.20.1-0.2-0.0-0.0
Context. condit. distance diff. score0.60.82.30.1-0.3-0.5-0.6-0.91.11.1-1.5
Locomotion velocity, session 10.10.10.3-0.20.40.40.40.4-0.2-0.30.5
Locomotion distance, session 10.10.10.50.7-0.4-0.3-0.3-0.00.2-0.00.2
Locomotion velocity, session 20.00.00.10.3-0.3-0.2-0.2-0.1-0.1-0.10.1
Locomotion distance, session 20.10.20.80.9-0.6-0.4-0.4-0.10.20.00.2
Locomotion velocity, session 30.91.11.5-1.21.21.11.11.0-0.9-0.90.8
Locomotion distance, session 30.20.20.5-0.70.40.50.50.4-0.6-0.4-0.2
Stereotopy head waving bouts, day 30.50.61.0-0.70.80.80.80.9-0.7-0.81.0
Stereotopy head waving duration, day 31.72.03.0-1.21.41.41.41.5-1.3-1.41.7
Locomotion velocity, session 73.23.57.11.2-1.3-1.6-1.6-1.92.22.1-2.7
Locomotion distance, session 73.54.57.31.7-1.7-1.9-1.9-2.12.42.3-2.7
Stereotopy head waving bouts, day 71.41.62.3-1.01.01.11.21.2-1.5-1.51.4
Stereotopy head waving duration, day 72.22.73.3-1.61.51.61.61.7-1.8-1.81.7
Locomotion velocity, session 80.00.10.2-0.40.30.30.30.2-0.0-0.10.0
Locomotion distance, session 80.60.81.30.8-0.7-0.8-0.8-0.91.10.9-1.1
Degree of sensitization distance7.07.510.12.6-2.3-2.6-2.6-2.73.23.1-2.7
Degree of sensitization stereotypy1.11.31.8-1.00.91.11.11.1-1.3-1.31.1
Conditioned locomotion0.10.10.4-0.60.30.20.20.1-0.1-0.2-0.3
Cocaine response after cond. corrected0.81.22.4-1.51.31.21.21.0-0.7-0.80.3
Cocaine response after cond. not corrected0.50.81.6-1.31.11.01.00.8-0.6-0.60.2
Cocaine response before conditioning0.60.71.51.2-1.1-1.0-0.9-0.80.50.6-0.3
Saline control response0.50.71.21.1-1.0-0.9-0.9-0.80.60.7-0.3
Bone: connectivity density2.43.94.51.7-1.9-2.0-2.0-2.02.12.1-2.0
Bone: cortical apparent density0.10.10.4-0.00.1-0.1-0.1-0.20.60.3-0.6
Bone: cortical area0.10.10.50.7-0.5-0.4-0.4-0.20.10.10.1
Bone: cortical porosity1.21.31.7-0.80.91.11.11.2-1.3-1.31.3
Bone: cortical porosity0.60.71.2-0.40.50.70.70.9-1.0-1.01.1
Bone: cortical thickness0.00.00.10.3-0.2-0.2-0.2-0.10.1-0.10.1
Bone: cortical thickness0.00.00.1-0.30.20.10.10.00.0-0.0-0.3
Bone: cortical tissue density0.10.10.5-0.10.1-0.1-0.1-0.20.70.4-0.7
Condit. Reinf. active minus inactive responses0.40.40.9-0.30.60.60.60.8-0.6-0.81.0
Condit. Reinf. active-inactive response ratio2.52.72.9-1.61.71.71.71.7-1.4-1.61.6
Condit. Reinf. active responses0.10.10.50.7-0.3-0.3-0.3-0.00.2-0.00.3
Condit. Reinf. inactive responses3.34.36.62.6-2.4-2.2-2.2-2.01.81.8-1.4
Incentive salience index mean0.60.81.7-0.30.60.70.81.0-0.8-1.11.3
Condit. Reinf. lever presses0.20.41.00.20.20.40.40.7-0.6-0.91.0
Condit. Reinf. active minus inactive responses0.30.50.60.7-0.7-0.7-0.7-0.70.60.7-0.6
Condit. Reinf. active-inactive response ratio0.00.10.2-0.40.30.20.20.1-0.1-0.10.2
Condit. Reinf. active responses0.91.31.51.1-1.2-1.2-1.2-1.20.91.2-1.1
Condit. Reinf. inactive responses1.72.62.91.7-1.7-1.6-1.7-1.61.31.6-1.6
Condit. Reinf. lever presses0.30.40.80.9-0.9-0.7-0.7-0.60.20.4-0.2
Condit. Reinf. lever reinforcers received0.81.21.31.1-1.2-1.1-1.1-1.10.81.1-1.0
Conditioned reinforcement - actives0.41.62.11.1-1.1-1.2-1.2-1.31.41.4-1.4
Conditioned reinforcement - inactives1.85.05.42.3-2.3-2.3-2.3-2.32.02.3-2.0
Conditioned locomotion0.10.20.40.2-0.2-0.3-0.3-0.40.50.4-0.6
Patch foraging indifference point 0 sec2.15.89.83.1-2.8-2.6-2.5-2.22.22.0-1.5
Patch foraging indifference point AUC0.41.01.8-1.41.21.11.00.9-1.0-0.70.5
Delay disc. indifference point, 0s delay0.50.51.11.1-0.9-0.8-0.8-0.60.50.6-0.1
Delay disc. indifference point, 16s delay0.20.20.40.3-0.4-0.5-0.5-0.50.60.6-0.5
Delay disc. indifference point, 2s delay1.01.12.2-0.50.70.90.91.1-1.4-1.21.5
Delay disc. indifference point, 24s delay0.10.20.3-0.40.50.50.50.5-0.3-0.40.5
Delay disc. indifference point, 4s delay1.92.02.4-1.41.31.41.41.4-1.6-1.41.5
Delay disc. indifference point, 8s delay0.00.00.00.1-0.0-0.0-0.0-0.00.10.00.1
Indifference point function ln k0.10.31.01.0-0.6-0.6-0.5-0.30.60.3-0.0
Indifference point function log k0.10.31.01.0-0.6-0.6-0.5-0.30.60.3-0.0
Patch foraging total patch changes 0 sec1.64.78.42.9-2.5-2.3-2.3-1.92.01.8-1.2
Patch foraging total patch changes 12 sec0.71.01.41.2-1.1-1.1-1.1-1.00.80.9-0.6
Patch foraging total patch changes 18 sec0.71.72.01.4-1.4-1.3-1.3-1.31.31.2-1.2
Patch foraging total patch changes 24 sec0.00.10.50.7-0.5-0.3-0.3-0.10.2-0.00.2
Patch foraging total patch changes 6 sec0.40.81.31.1-0.9-0.9-0.9-0.80.80.8-0.6
Patch foraging time to switch 0 sec0.20.81.00.6-0.9-0.9-0.9-1.01.00.9-0.9
Patch foraging water rate 0 sec0.20.60.9-0.50.60.70.70.8-0.9-0.80.9
Patch foraging water rate 12 sec0.20.81.3-0.50.70.80.81.0-1.1-1.01.1
Patch foraging water rate 18 sec1.53.33.7-1.61.81.81.81.9-1.8-1.81.9
Patch foraging water rate 24 sec0.10.10.3-0.30.50.40.40.4-0.2-0.20.2
Patch foraging water rate 6 sec1.92.94.2-1.21.41.61.61.8-2.0-1.82.0
Seeking ratio, delayed vs. immediate footshock0.70.91.51.2-1.2-1.0-1.0-0.90.90.6-0.8
Distance traveled before self-admin0.40.91.7-0.70.70.80.80.9-1.1-0.91.3
Distance traveled after self-admin1.62.94.0-1.41.71.71.71.8-1.4-1.72.0
Extensor digitorum longus weight12.750.751.8-7.07.17.27.27.2-7.1-7.17.0
Bone: elastic displacement0.40.51.00.9-1.0-0.8-0.8-0.70.40.5-0.3
Bone: elastic work0.60.81.81.3-1.2-1.0-1.0-0.70.50.5-0.1
Bone: endosteal estimation0.00.00.20.5-0.2-0.2-0.2-0.10.00.10.1
Bone: endosteal perimeter0.00.10.40.6-0.4-0.3-0.3-0.1-0.10.10.3
Epididymis fat weight0.62.83.11.7-1.7-1.7-1.7-1.71.61.8-1.4
Delta time in closed arm before/after self-admin3.02.83.01.6-1.7-1.7-1.7-1.71.51.6-1.7
Delta time in open arm before/after self-admin0.10.10.3-0.40.20.20.20.1-0.5-0.10.2
Diff in mean of infusions in LGA sessions0.20.30.8-0.30.50.50.50.6-0.3-0.70.9
Delay discount exponential model param0.30.40.70.5-0.6-0.6-0.6-0.70.70.7-0.8
Extinction: sum of active levers before priming1.52.32.91.6-1.5-1.5-1.5-1.41.71.6-1.2
Active lever presses in extinction session 60.30.31.00.2-0.2-0.3-0.3-0.41.00.5-0.7
Bone: final force0.00.00.10.2-0.00.00.00.1-0.1-0.10.4
Bone: final moment0.00.10.30.6-0.3-0.2-0.2-0.00.10.00.4
Food consumed during 24 hour testing period0.40.81.61.3-1.0-1.0-1.0-0.80.80.9-0.5
Glucose0.00.00.1-0.30.30.10.10.00.10.2-0.1
Heart weight0.81.31.61.3-1.1-1.2-1.2-1.11.01.2-1.1
Delay discount hyperbolic model param0.40.50.90.6-0.6-0.7-0.7-0.80.80.7-1.0
Intermittent access intake day 1-15 change0.52.83.71.3-1.6-1.7-1.7-1.81.41.9-1.8
Intermittent access intake escalation0.53.03.91.4-1.7-1.7-1.8-1.91.42.0-1.8
Intermittent access intake escalation 20.81.42.00.9-1.1-1.2-1.2-1.30.81.4-1.3
Intermitt. access day 1 inactive lever presses0.00.00.0-0.10.1-0.0-0.0-0.10.10.2-0.2
Intermitt. access day 15 inactive lever presses0.00.00.1-0.10.1-0.0-0.0-0.10.20.2-0.4
Intermitt. access escalation Index0.00.10.2-0.10.10.10.10.2-0.5-0.20.3
Intermittent access day 1 total infusions0.00.00.00.2-0.1-0.1-0.1-0.10.20.0-0.0
Intermittent access day 15 total infusions0.92.12.71.2-1.4-1.4-1.4-1.51.31.6-1.6
Intermittent access terminal intake (last 3 days)0.61.01.60.7-0.9-1.0-1.0-1.10.91.2-1.2
Intermittent access total infusions1.11.31.70.9-1.0-1.1-1.1-1.11.31.2-1.3
Intermittent access day 1 locomotion0.10.10.40.6-0.5-0.4-0.4-0.20.20.1-0.1
Intermittent access day 15 total locomotion0.10.30.60.3-0.4-0.5-0.5-0.60.50.6-0.8
Intermittent access total locomotion0.10.20.20.5-0.4-0.4-0.4-0.40.30.4-0.4
Intermittent access standard deviation0.00.20.40.2-0.4-0.4-0.4-0.50.30.6-0.5
Left kidney weight0.00.10.30.6-0.2-0.1-0.10.10.0-0.30.3
Right kidney weight0.00.31.51.2-0.7-0.5-0.5-0.10.2-0.10.3
Cocaine induced anxiety0.00.10.40.7-0.5-0.3-0.3-0.1-0.20.00.4
Post-drug Anxiety1.21.42.71.6-1.5-1.3-1.3-1.01.00.8-0.7
Baseline Anxiety0.30.40.80.6-0.6-0.6-0.6-0.60.90.5-0.9
Tail length0.42.33.81.9-1.7-1.6-1.6-1.41.21.2-1.2
Length with tail0.00.20.70.8-0.3-0.1-0.10.2-0.2-0.50.6
Length without tail1.15.68.3-1.62.12.22.22.5-2.5-2.72.9
Times rat made contact with spout0.70.80.90.9-0.8-0.9-0.9-0.90.91.0-0.9
Lifetime Intake0.70.81.30.8-0.8-0.8-0.8-0.91.10.9-1.0
Liver weight, left1.22.03.6-0.91.21.31.31.5-1.6-1.51.9
Liver weight, right0.81.42.1-1.41.31.31.21.1-1.2-1.01.0
Locomotor activity1.01.63.9-0.30.60.90.91.3-1.6-1.62.0
Locomotor testing distance0.30.82.31.5-1.3-1.0-0.9-0.60.30.30.2
Locomotor testing rearing0.41.53.92.0-1.7-1.3-1.3-0.90.50.5-0.1
Locomotion in novel chamber0.40.51.00.6-0.7-0.7-0.8-0.80.31.0-0.7
Locomotion in novel chamber post-restriction0.41.21.6-1.11.21.11.21.2-0.8-1.31.0
Fecal boli incidents, locomotor time 10.20.60.9-0.50.80.80.80.9-0.7-0.80.9
Change in fecal boli incidents, locomotor task0.50.51.0-1.00.80.80.80.6-0.5-0.60.3
Time >=10cm from walls, locomotor time 11.21.51.71.3-1.3-1.3-1.3-1.21.21.2-1.0
Bouts of movement, locomotor time 14.45.76.4-2.32.52.52.52.5-2.3-2.42.2
Total resting periods, locomotor time 15.15.97.2-2.52.72.62.62.5-2.2-2.32.1
Rest time, locomotor task time 12.03.24.3-2.12.11.91.91.8-1.6-1.61.3
Distance moved, locomotor task time 11.02.93.61.8-1.9-1.8-1.8-1.71.51.6-1.4
Vertical activity count, locomotor time 10.10.81.61.0-1.3-1.0-1.0-0.90.40.7-0.3
Time >=10cm from walls, locomotor time 20.20.50.6-0.70.80.70.70.7-0.5-0.60.8
Bouts of movement, locomotor time 21.55.06.0-2.42.52.42.42.3-1.9-2.12.0
Total resting periods, locomotor time 21.45.66.9-2.62.62.52.52.4-2.0-2.22.0
Rest time, locomotor task time 21.11.83.2-1.81.61.51.51.3-1.1-1.10.8
Distance moved, locomotor task time 22.63.54.62.1-2.1-2.0-2.0-1.91.71.7-1.3
Vertical activity count, locomotor time 20.20.61.01.0-1.0-0.8-0.8-0.70.50.50.0
Light reinforcement 11.04.56.01.9-2.1-2.1-2.1-2.22.02.2-2.5
Light reinforcement 20.41.02.30.4-0.7-0.8-0.8-1.01.01.2-1.5
Bone: marrow area0.00.10.30.6-0.3-0.3-0.3-0.20.10.3-0.0
Bone: maximum diameter0.10.30.5-0.30.50.50.50.6-0.6-0.60.7
Bone: maximum force0.10.10.60.10.20.20.20.4-0.4-0.40.8
Bone: maximum moment0.10.10.50.5-0.2-0.1-0.10.1-0.1-0.20.7
Mean time between licks in bursts0.42.73.11.8-1.7-1.7-1.7-1.61.71.6-1.4
Mean num. licks in bursts0.20.60.91.0-0.8-0.8-0.8-0.80.80.7-0.6
Cd content in liver1.01.22.2-0.70.81.01.01.1-1.1-1.21.5
Co content in liver5.05.96.9-2.52.62.52.52.5-2.2-2.32.3
Cu content in liver0.60.70.9-1.01.00.90.90.9-0.7-0.80.7
Fe content in liver1.92.32.51.6-1.5-1.5-1.5-1.51.61.5-1.6
K content in liver0.70.71.70.5-0.7-0.7-0.8-0.90.80.8-1.3
Mg content in liver1.82.03.01.2-1.4-1.4-1.4-1.51.31.3-1.7
Mn content in liver2.52.83.11.7-1.7-1.7-1.7-1.71.51.7-1.5
Na content in liver0.91.01.8-0.60.70.90.91.0-1.1-1.21.3
Rb content in liver0.00.00.20.0-0.1-0.1-0.1-0.10.10.1-0.4
Se content in liver1.41.62.61.6-1.6-1.4-1.4-1.20.91.0-0.7
Sr content in liver0.00.00.00.1-0.1-0.1-0.1-0.1-0.00.10.1
Zn content in liver0.20.20.40.6-0.5-0.5-0.4-0.40.50.3-0.2
Bone: minimum diameter0.00.10.30.5-0.2-0.1-0.10.1-0.2-0.10.6
Time in familiar zone, hab. session 10.00.00.0-0.10.10.10.10.1-0.0-0.1-0.1
Time in novel zone, hab. session 11.41.51.8-1.31.31.31.31.2-1.1-1.11.1
Total zone transitions, hab. session 10.10.10.40.10.30.30.30.5-0.2-0.40.6
Total locomotion distance, hab. session 10.10.10.60.8-0.4-0.3-0.3-0.10.30.10.1
Locomotion velocity, hab. session 10.40.51.61.3-0.9-0.8-0.7-0.50.60.4-0.1
Time in familiar zone, hab. session 21.72.02.9-1.61.71.51.51.4-1.2-1.21.1
Time in novel zone, hab. session 20.60.71.11.0-1.0-0.9-0.9-0.80.70.7-0.5
Total zone transitions, hab. session 21.41.82.4-0.91.11.31.31.4-1.3-1.61.6
Total locomotion distance, hab. session 20.30.40.8-0.40.50.60.60.7-0.6-0.90.8
Locomotion velocity, hab. session 20.60.91.3-0.60.70.90.91.0-0.9-1.21.1
Novel to familiar place preference ratio0.81.11.51.0-1.2-1.1-1.1-1.10.90.9-0.9
Novelty place preference0.60.81.20.9-1.1-0.9-0.9-0.90.80.8-0.8
Time in novel zone, NPP test0.30.30.60.6-0.8-0.6-0.6-0.60.50.5-0.4
Total zone transitions, NPP test0.20.30.90.9-0.7-0.6-0.6-0.40.50.3-0.3
Total locomotion distance, NPP test2.94.05.72.4-2.2-2.1-2.1-1.91.91.7-1.7
Locomotion velocity, NPP test2.73.95.42.3-2.1-2.1-2.0-1.91.81.7-1.7
Intraocular pressure0.61.01.31.2-1.0-1.0-1.0-0.90.91.0-0.6
Delta distance traveled before/after self-admin2.93.24.2-1.72.01.91.91.9-1.2-1.81.7
Delta ambulatory time before/after self-admin1.83.13.9-1.62.01.81.91.9-1.2-1.81.7
Parametrial fat weight2.55.97.42.5-2.4-2.4-2.4-2.32.72.2-2.4
Pavlov. Cond. lever latency0.00.00.1-0.40.20.20.1-0.00.10.2-0.1
Pavlov. Cond. magazine entry latency0.20.20.50.7-0.5-0.5-0.5-0.40.40.5-0.2
Pavlov. Cond. change in total contacts0.90.91.8-0.50.70.80.81.0-1.0-1.21.3
Pavlov. Cond. index score0.00.10.20.2-0.00.00.10.2-0.3-0.30.4
Pavlov. Cond. latency score0.00.00.20.4-0.2-0.1-0.10.0-0.1-0.20.3
Pavlov. Cond. lever contacts0.00.10.20.5-0.3-0.2-0.2-0.10.1-0.10.0
Pavlov. Cond. magazine entry number0.10.20.50.0-0.3-0.3-0.3-0.40.40.4-0.7
Pavlov. Cond. intertrial magazine entries0.30.30.80.9-0.7-0.6-0.6-0.50.50.3-0.2
Pavlov. Cond. lever-magazine prob. diff.0.10.10.30.10.10.20.20.4-0.4-0.50.6
Pavlov. Cond. response bias0.10.10.20.00.20.20.20.3-0.2-0.30.5
Pavlov. Cond. lever latency0.40.61.30.4-0.3-0.5-0.5-0.71.10.9-1.1
Pavlov. Cond. magazine entry latency0.10.20.40.7-0.6-0.5-0.5-0.3-0.00.2-0.1
Pavlov. Cond. change in total contacts0.71.72.7-1.01.11.21.21.3-1.6-1.41.7
Pavlov. Cond. index score0.30.51.2-0.20.30.50.50.6-1.1-0.81.0
Pavlov. Cond. latency score0.20.30.8-0.00.10.30.30.5-0.9-0.60.9
Pavlov. Cond. lever contacts0.20.30.8-0.00.10.30.30.4-0.9-0.60.9
Pavlov. Cond. magazine entry number0.10.10.2-0.50.40.30.30.20.2-0.0-0.1
Pavlov. Cond. intertrial magazine entries4.08.79.22.9-2.9-3.0-3.0-3.03.03.0-2.8
Pavlov. Cond. lever-magazine prob. diff.0.40.61.3-0.40.40.60.60.7-1.2-0.91.1
Pavlov. Cond. response bias0.30.41.0-0.10.10.30.40.5-1.0-0.70.9
Time in closed arm before self-admin0.71.21.6-1.11.21.11.21.2-0.9-1.21.0
Time in closed arm after self-admin0.00.00.10.3-0.1-0.2-0.1-0.00.2-0.2-0.1
Time in open arm before self-admin0.00.00.00.20.00.00.00.10.0-0.20.1
Time in open arm after self-admin0.00.00.2-0.30.10.10.10.0-0.40.20.1
Bone: periosteal estimation0.00.10.40.7-0.4-0.3-0.3-0.20.10.10.1
Bone: periosteal perimeter0.00.10.20.5-0.3-0.2-0.2-0.1-0.20.00.2
Bone: post-yield work0.10.20.50.1-0.2-0.3-0.3-0.50.60.6-0.7
Progressive ratio test 1 active lever presses0.10.10.2-0.40.40.30.30.30.1-0.2-0.0
Progressive ratio test 1 breakpoint0.10.10.3-0.50.50.40.40.40.1-0.30.1
Progressive ratio test 1 inactive lever presses0.41.11.50.7-0.8-1.0-1.0-1.11.21.2-1.2
Progressive ratio test 2 active lever presses0.10.10.50.3-0.1-0.1-0.1-0.10.70.2-0.2
Progressive ratio test 2 breakpoint0.10.10.50.4-0.1-0.1-0.1-0.10.70.1-0.2
Progressive ratio test 2 inactive lever presses0.20.51.00.8-0.6-0.7-0.6-0.61.00.6-0.9
Incentive Sensitization - Responses0.20.51.01.0-0.7-0.7-0.7-0.61.00.5-0.3
Incentive Sensitization - Breakpoint0.30.71.31.1-0.9-0.8-0.8-0.71.00.7-0.4
Sum of active levers in priming session hrs 5-60.10.10.4-0.10.20.00.0-0.10.60.2-0.3
Progressive ratio0.10.30.8-0.70.40.50.50.4-0.9-0.50.5
Food seeking constrained by brief footshock2.83.55.7-2.42.32.02.01.7-1.5-1.51.3
Seeking ratio, punishment vs. effort0.30.61.2-0.91.10.80.80.7-0.2-0.60.6
Retroperitoneal fat weight0.20.81.21.0-0.8-0.9-0.9-0.81.10.9-0.8
Reaction time number correct0.31.01.6-1.11.31.11.11.0-1.0-0.80.8
Reaction time mean minus median0.00.30.4-0.40.50.50.50.5-0.5-0.50.6
Reaction time mean minus median AUC0.00.20.3-0.40.50.50.50.5-0.5-0.50.5
Reaction time num false alarms0.00.10.30.4-0.1-0.2-0.1-0.00.50.20.3
Reaction time num false alarms AUC0.00.10.30.4-0.1-0.2-0.2-0.10.50.20.2
Reaction time trials correct on left0.31.01.6-1.11.31.11.11.0-1.0-0.80.8
Reaction time trials on left0.20.81.3-1.01.11.01.00.9-0.8-0.60.7
Reaction time mean0.20.40.5-0.50.60.70.70.7-0.7-0.70.7
Reaction time mean AUC0.30.80.9-0.70.80.80.80.9-1.0-0.91.0
Median of all reaction times0.30.40.4-0.50.60.60.60.7-0.7-0.60.7
Reaction time omissions1.32.12.41.3-1.5-1.5-1.5-1.51.31.6-1.6
Reaction time false alarm rate0.40.51.00.9-0.7-0.7-0.7-0.61.00.6-0.3
Reaction time premature initiation rate1.52.32.8-1.51.71.61.61.6-1.3-1.61.4
Reaction time premature initiations1.23.64.7-2.02.22.02.02.0-1.6-1.81.6
Std. dev. reaction times0.10.30.4-0.50.60.60.60.6-0.4-0.60.6
Reaction time trials completed0.20.81.3-1.01.11.01.00.9-0.8-0.60.7
Reaction time trials AUC0.20.71.2-0.91.10.90.90.9-0.8-0.60.7
Run reversals in cocaine runway, females2.52.83.11.5-1.7-1.7-1.7-1.81.71.7-1.6
Run reversals in cocaine runway, males2.02.22.8-1.61.41.51.51.4-1.7-1.31.6
Latency to leave start box in cocaine runway1.31.73.2-1.61.21.31.31.1-1.8-1.00.9
Latency to leave start box in cocaine runway, F2.93.66.5-2.11.71.91.81.7-2.5-1.71.5
Latency to leave start box in cocaine runway, M0.10.10.20.0-0.1-0.2-0.2-0.30.30.4-0.1
Std. dev. time between licks in bursts1.83.55.72.4-2.1-2.0-2.0-1.71.71.6-1.0
Total sessions with >9 infusions0.00.00.0-0.10.20.10.10.10.1-0.10.1
Short access day 1 total inactive lever presses0.20.30.60.7-0.5-0.5-0.5-0.50.80.3-0.4
Short access day 10 total inactive lever presses0.00.20.30.3-0.4-0.4-0.4-0.40.20.4-0.5
Short access day 1 total infusions0.00.10.2-0.30.30.30.30.30.1-0.40.2
Short access day 10 total infusions0.10.20.5-0.30.30.40.40.5-0.5-0.60.7
Short access total infusions0.00.00.10.10.10.10.10.10.2-0.20.2
Short access day 1 locomotion0.40.71.2-0.40.70.70.80.9-0.9-1.11.1
Short access day 10 total locomotion0.00.10.30.5-0.5-0.4-0.4-0.3-0.00.1-0.1
Short access total locomotion0.00.10.20.2-0.1-0.00.00.1-0.4-0.30.4
One hour access (0.3 mA shock)0.70.91.01.0-0.9-0.9-0.9-0.91.00.9-0.9
Compulsive drug intake0.50.70.90.9-0.9-0.9-0.8-0.80.90.7-0.7
One hour access (shock baseline)0.00.00.00.10.0-0.0-0.0-0.00.00.1-0.1
Social response proportion0.30.40.8-0.90.90.70.70.6-0.4-0.50.0
Social responses1.31.72.41.4-1.1-1.3-1.2-1.21.31.3-1.6
Social time0.30.50.91.0-0.9-0.7-0.7-0.60.30.4-0.6
Soleus weight1.33.84.4-2.12.12.02.01.9-1.9-1.81.8
Bone: stiffness0.40.70.8-0.70.90.80.80.9-0.7-0.80.9
Tibialis anterior weight8.128.028.9-5.15.25.35.35.4-5.3-5.35.3
Time to tail flick, vehicle, before self-admin1.01.21.51.1-1.1-1.1-1.1-1.11.21.1-1.1
Time to tail flick, vehicle, after self-admin1.73.56.6-2.62.01.91.91.6-1.8-1.51.2
Time to tail flick, test, before self-admin3.43.94.72.2-2.0-2.0-2.0-1.92.11.9-1.7
Time to tail flick, test, after self-admin2.12.34.31.3-1.1-1.3-1.3-1.41.91.3-2.1
Delta time to tail flick, vehicle, before/after SA0.91.02.3-1.51.11.11.00.8-0.9-0.80.4
Delta time to tail flick, test, before/after SA0.20.20.5-0.70.60.40.40.20.0-0.2-0.6
Tibia length1.95.29.03.0-2.8-2.5-2.4-2.11.81.7-1.4
Ambulatory time before self-admin0.10.30.8-0.30.30.40.40.5-0.9-0.50.8
Ambulatory time after self-admin3.65.77.4-2.12.42.42.42.5-2.1-2.52.7
Bone: tissue strength0.20.20.40.6-0.6-0.5-0.5-0.50.40.4-0.2
Total heroin consumption0.60.71.0-0.80.80.80.80.8-0.4-0.81.0
Bone: trabecular number2.14.04.21.9-2.0-2.0-2.0-2.02.12.0-1.9
Bone: trabecular spacing2.13.03.5-1.71.71.71.71.8-1.9-1.81.7
Bone: trabecular thickness1.11.51.81.3-1.3-1.3-1.3-1.21.31.2-0.9
Bone: trabecular tissue density1.01.82.5-1.21.31.31.31.4-1.2-1.31.6
Water consumed over 24 hours0.61.21.6-0.81.11.11.11.1-1.2-1.01.3
Number of responses in last shaping day0.50.60.9-0.70.70.80.80.8-0.7-0.81.0