Hub : Traits

BMI with tail

Tags: Physiology · Weight

Project: dissection

898 significantly associated models · 186 unique genes

Significant Loci

# chr p0 p1 # assoc genes # joint models best TWAS P best SNP P cond SNP P % var exp joint genes
1 1 201865024 205361167 28 4 7.1e-09 1.1e-08 NaN NaN Ovol1 Slc22a12 Kcnk4 Macrod1
2 1 206890006 208286941 1 1 3.1e-08 2.2e-05 6.6e-01 99 Ptgdr2
3 1 253445764 260518987 32 7 5.5e-34 1.8e-35 1.0e+00 100 Rab11fip2 Cacul1 Prdx3 Acsl5 Sfxn4 NA NA
4 2 117887529 119795716 3 1 1.0e-07 8.1e-08 1.0e+00 100 Atp11b
5 2 123236866 125075599 2 1 3.7e-09 2.0e-05 8.6e-01 100 Jade1
6 3 129554891 132693612 14 5 3.8e-12 1.3e-12 1.0e+00 100 Kif16b Snrpb2 Pcsk2 Dstn Otor
7 7 29535 2057232 29 5 1.2e-08 1.2e-08 1.0e+00 100 Spryd4 Cnpy2 Dnajc14 Sarnp Timeless
8 7 6571870 7969119 1 1 2.4e-07 2.7e-07 1.0e+00 100 NA
9 7 81442141 82840708 1 1 8.1e-09 9.1e-11 2.2e-03 78 Trps1
10 7 117926546 119313462 1 1 4.1e-08 1.0e-06 8.7e-02 88 Tafa5
11 7 128140829 129538159 1 1 1.4e-07 7.8e-06 9.2e-01 100 Rpap3
12 8 70127064 71520043 1 1 2.2e-07 7.0e-07 3.1e-20 -245 Fam81a
13 8 72966755 74474378 3 1 1.4e-08 2.3e-07 5.7e-01 99 Pygo1
14 8 77504998 78898375 1 1 3.3e-07 3.0e-07 5.2e-02 86 Mlip
15 8 95494368 98183778 7 2 3.1e-09 4.1e-09 1.0e+00 100 Zbtb38 Trpc1
16 9 65337960 67262437 6 1 1.3e-08 3.3e-08 1.0e+00 100 Fzd5
17 10 79556862 83093905 37 6 6.3e-17 1.7e-17 1.0e+00 100 Phospho1 Gip Hoxb9 Zfp652 Pnpo Cdk5rap3
18 10 92588108 95279450 8 1 1.8e-08 5.0e-09 1.0e+00 100 Prkca
19 10 105499327 106889481 1 1 2.3e-07 5.2e-03 1.2e-01 69 Ccdc57
20 18 25070927 26946372 8 1 4.0e-10 4.3e-08 7.5e-01 100 Reep5
21 18 29556452 30949426 1 1 1.4e-07 7.4e-07 1.0e+00 100 Ndfip1

p0: physical position of the start of the locus. p1: physical position of the end of the locus. # joint models: number of models selected by step-wise conditional analysis.

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
BMI without tail 14.3 31 14 31.8 1.00 2.6e-124 Wipi1 Kif16b Snrpb2 Pcsk2 Dstn Rrbp1 Rbbp9 Sec23b Dtd1 Pdzd8 Rab11fip2 Prlhr Pls1 Cacul1 Dennd10 Prdx3 Grk5 Atp1b3 Reep5 Trps1 Nanos1 Epb41l4a Zfp133 Otor Zfp950 Ces2c Sfxn4 Trpc1 NA NA NA
Body weight 12.1 104 78 177.3 0.99 0.0e+00 Amz2 Prkca Apoh Rgs9 Wipi1 Kif16b Snrpb2 Pcsk2 Dstn Mlip Rrbp1 Kat14 Dzank1 Rbbp9 Sec23b Dtd1 Nfe2l1 Pdzd8 Rab11fip2 Prlhr Pls1 Cacul1 Dennd10 Gk5 Prdx3 Tfdp2 Grk5 Atp1b3 Zbtb38 Dcun1d1 Znrd2 Jade1 Qrfpr Gpam Tectb Gucy2g Acsl5 Habp2 Nrap Nhlrc2 Afap1l2 Fhip2a Trub1 Atrnl1 AABR07007068.1 Nme5 Reep5 Brd8 Fam13b Apc Ovol1 Capn1 Naaladl1 Sac3d1 Nrxn2 Slc22a12 Rps6ka4 Kcnk4 Fermt3 Macrod1 Otub1 Rtn3 Arhgap23 Scyl1 Cdc23 Cep112 Trps1 Nanos1 Pkd2l2 Epb41l4a Dclre1a Snx32 Zfp133 Mgme1 Otor Zfp950 AABR07030647.1 Ces2c Sfxn4 Zdhhc6 Ptgdr2 Larp1b Dnajc4 AABR07007032.1 Cdca5 PCOLCE2 Ccdc57 Tcf7l2 Tafa5 Atp11b Rpap3 Ccpg1 Trpc1 Axin2 Ehbp1l1 Casp7 Fam81a Pigb NA NA Pygo1 NA NA NA
Epididymis fat weight 18.9 50 36 81.8 0.99 2.0e-211 Amz2 Prkca Apoh Rgs9 Wipi1 Kif16b Snrpb2 Pcsk2 Dstn Rrbp1 Rbbp9 Sec23b Pdzd8 Rab11fip2 Prlhr Cacul1 Dennd10 Prdx3 Grk5 Gpam Tectb Gucy2g Acsl5 Habp2 Nrap Nhlrc2 Afap1l2 Fhip2a Trub1 Atrnl1 AABR07007068.1 Cep112 Nanos1 Dclre1a Zfp133 Mgme1 Otor Zfp950 AABR07030647.1 Ces2c Sfxn4 Zdhhc6 AABR07007032.1 Tcf7l2 Axin2 Casp7 NA NA NA NA
Glucose 10.8 2 0 0.0 0.00 1.0e+00 Zfp950 Sfxn4
Heart weight 12.5 3 0 0.0 0.00 1.0e+00 Cacul1 Nanos1 Sfxn4
Left kidney weight 10.5 21 13 29.5 0.99 9.3e-47 Rab11fip2 Prlhr Cacul1 Dennd10 Prdx3 Grk5 Gpam Gucy2g Acsl5 Nhlrc2 Nanos1 Zfp950 Ces2c Sfxn4 Tcf7l2 Tafa5 Trpc1 NA NA NA NA
Right kidney weight 9.3 30 13 29.5 0.99 2.1e-64 Rab11fip2 Prlhr Cacul1 Dennd10 Prdx3 Grk5 Gpam Gucy2g Acsl5 Habp2 Nrap Nhlrc2 Afap1l2 Fhip2a Trub1 Atrnl1 Nanos1 Dclre1a Zfp950 Ces2c Sfxn4 AABR07007032.1 Tcf7l2 Tafa5 Trpc1 Casp7 NA NA NA NA
Tail length 9.7 59 36 81.8 -1.00 0.0e+00 Hsd17b6 Ptges3 Atp5f1b Rbms2 Spryd4 Il23a Cnpy2 Spop Pa2g4 Ttll6 Ngfr Phospho1 Abi3 Gip Snf8 Dnajc14 Ube2z Atp5mc1 Hoxb9 Gdf11 Bloc1s1 Hoxb4 Hoxb3 NA Snx11 Cbx1 Nfe2l1 Copz2 Kpnb1 Osbpl7 Mrpl10 Lrrc46 Scrn2 Sp2 Mrpl45 Mettl21a Zfp652 Kat7 Npepps Rnf41 Cs Sp6 Skap1 Sarnp Stat2 Smarcc2 Gls2 Timeless Prim1 Pnpo Phb Cdk5rap3 Prr15l Myl6 Esyt1 Apof B4galnt2 Atp5mc1 NA
Length with tail 7.3 46 33 75.0 -0.93 2.7e-98 Spop Ttll6 Kif16b Ngfr Phospho1 Abi3 Gip Snf8 Ube2z Atp5mc1 Hoxb9 Hoxb4 Hoxb3 NA Snx11 Cbx1 Nfe2l1 Copz2 Kpnb1 Osbpl7 Mrpl10 Lrrc46 Cacul1 Scrn2 Sp2 Mrpl45 Mettl21a Fzd5 Idh1 Pikfyve Zfp652 Kat7 Npepps Sp6 Plekhm3 Skap1 Otor Sfxn4 Cryga Pnpo Phb Cdk5rap3 Prr15l B4galnt2 Atp5mc1 NA
Length without tail 7.9 9 0 0.0 0.97 2.3e-11 Cacul1 Gpam Gucy2g Acsl5 Habp2 Dclre1a Sfxn4 Tcf7l2 Casp7
Liver weight, left 10.5 2 0 0.0 1.00 2.0e-06 Rab11fip2 Cacul1
Liver weight, right 12.7 18 4 9.1 0.98 1.5e-36 Pdzd8 Rab11fip2 Prlhr Cacul1 Grk5 Gpam Tectb Acsl5 Habp2 Nhlrc2 Nanos1 Dclre1a Zfp950 Sfxn4 Zdhhc6 Tcf7l2 Casp7 NA
Parametrial fat weight 17.0 44 27 61.4 0.99 1.1e-161 Kif16b Snrpb2 Pcsk2 Dstn Rrbp1 Kat14 Dzank1 Rbbp9 Sec23b Dtd1 Pdzd8 Rab11fip2 Prlhr Cacul1 Dennd10 Prdx3 Grk5 Gpam Tectb Acsl5 Habp2 Nrap Nhlrc2 Afap1l2 Fhip2a Trub1 Atrnl1 AABR07007068.1 Nanos1 Dclre1a Zfp133 Mgme1 Otor Zfp950 Ces2c Sfxn4 Zdhhc6 AABR07007032.1 Tcf7l2 Casp7 NA NA NA NA
Retroperitoneal fat weight 21.9 54 46 104.5 0.99 3.2e-236 Amz2 Prkca Apoh Rgs9 Wipi1 Kif16b Snrpb2 Pcsk2 Dstn Rrbp1 Kat14 Dzank1 Rbbp9 Sec23b Dtd1 Pdzd8 Rab11fip2 Prlhr Cacul1 Dennd10 Prdx3 Grk5 Gpam Tectb Gucy2g Acsl5 Habp2 Nrap Nhlrc2 Afap1l2 Fhip2a Trub1 Atrnl1 AABR07007068.1 Cep112 Nanos1 Dclre1a Zfp133 Mgme1 Otor Zfp950 AABR07030647.1 Ces2c Sfxn4 Zdhhc6 AABR07007032.1 Tcf7l2 Axin2 Casp7 NA NA NA NA NA
Extensor digitorum longus weight 5.4 51 21 47.7 1.00 1.4e-309 Hsd17b6 Ptges3 Atp5f1b Rbms2 Spryd4 Il23a Cnpy2 Pa2g4 Rab5b Tmem198b Dnajc14 Gdf11 Bloc1s1 Itga7 Dcun1d1 Znrd2 Jade1 Qrfpr Ovol1 Sac3d1 Slc22a12 Rps6ka4 Kcnk4 Macrod1 Otub1 Arhgap23 Dgka Rnf41 Cs Snx32 Sarnp Ankrd52 Stat2 Smarcc2 Gls2 Timeless Prim1 Pan2 NA Ptgdr2 Larp1b Zc3h10 Atp11b Ccpg1 Myl6 Ehbp1l1 Fam81a Pigb Esyt1 Apof Pygo1
Soleus weight 7.0 46 4 9.1 0.99 9.5e-246 Hsd17b6 Ptges3 Atp5f1b Rbms2 Spryd4 Il23a Cnpy2 Pa2g4 Rab5b Tmem198b Dnajc14 Gdf11 Bloc1s1 Itga7 Gpam Tectb Gucy2g Acsl5 Habp2 Fhip2a Trub1 Atrnl1 Dgka Rnf41 Cs Sarnp Ankrd52 Stat2 Smarcc2 Gls2 Timeless Prim1 Pan2 NA Zc3h10 AABR07007032.1 Tcf7l2 Ccpg1 Myl6 Casp7 Fam81a Pigb Esyt1 Apof NA Pygo1
Tibialis anterior weight 8.5 20 15 34.1 0.99 1.5e-27 Mlip Dcun1d1 Znrd2 Jade1 Qrfpr Ovol1 Sac3d1 Slc22a12 Kcnk4 Macrod1 Otub1 Snx32 Ptgdr2 Larp1b Atp11b Ccpg1 Ehbp1l1 Fam81a Pigb Pygo1
Tibia length 9.7 4 1 2.3 0.98 1.6e-05 Kif16b Otor Ccdc57 Rpap3
Delay discounting water rate 12 sec 12.6 8 0 0.0 -1.00 7.2e-18 Znrd2 Efemp2 Ovol1 Naaladl1 Sac3d1 Slc22a12 Snx32 Ehbp1l1
Std. dev. reaction times 12.1 1 0 0.0 0.00 1.0e+00 Jade1
Condit. Reinf. active responses 13.6 3 0 0.0 0.00 1.0e+00 Reep5 Fam13b Epb41l4a
Condit. Reinf. lever reinforcers received 13.2 2 0 0.0 0.00 1.0e+00 Reep5 Epb41l4a
Total zone transitions, NPP test 12.1 4 0 0.0 1.00 2.5e-10 Gk5 Tfdp2 PCOLCE2 Trpc1
Bone surface 10.0 1 0 0.0 0.00 1.0e+00 Rpap3
Bone volume 10.3 2 0 0.0 0.00 1.0e+00 Cacul1 Sfxn4
Bone: cortical area 13.8 22 1 2.3 0.97 1.3e-39 Rab11fip2 Prlhr Cacul1 Dennd10 Grk5 Acsl5 Habp2 Nhlrc2 Afap1l2 Nanos1 Dclre1a Zfp950 Ces2c Sfxn4 AABR07007032.1 Ccdc57 Tcf7l2 Rpap3 Casp7 NA NA NA
Bone: cortical thickness 14.2 5 1 2.3 0.88 1.5e-03 Rab11fip2 Cacul1 Ccdc57 NA NA
Bone: cortical thickness 21.9 1 0 0.0 0.00 1.0e+00 Ccdc57
Bone: elastic work 13.3 1 0 0.0 0.00 1.0e+00 Ccdc57
Bone: final force 12.4 9 1 2.3 0.93 1.4e-05 Rab11fip2 Cacul1 Grk5 Nanos1 Zfp950 Sfxn4 Ccdc57 Rpap3 NA
Bone: final moment 12.4 9 1 2.3 0.95 2.0e-08 Rab11fip2 Cacul1 Grk5 Nanos1 Zfp950 Sfxn4 Ccdc57 Rpap3 NA
Bone: maximum diameter 10.6 10 0 0.0 0.96 2.6e-19 Cacul1 Acsl5 Habp2 Nrap Nhlrc2 Afap1l2 Dclre1a AABR07007032.1 Tcf7l2 Casp7
Bone: maximum force 12.1 8 1 2.3 0.91 9.4e-05 Rab11fip2 Cacul1 Grk5 Zfp950 Sfxn4 Ccdc57 Rpap3 NA
Bone: maximum moment 11.9 8 1 2.3 0.93 1.2e-06 Rab11fip2 Cacul1 Grk5 Zfp950 Sfxn4 Ccdc57 Rpap3 NA
Bone: periosteal estimation 9.4 18 0 0.0 0.97 3.0e-26 Rab11fip2 Prlhr Cacul1 Dennd10 Grk5 Acsl5 Habp2 Nhlrc2 Nanos1 Dclre1a Zfp950 Ces2c Sfxn4 Ccdc57 Tcf7l2 Rpap3 Casp7 NA
Bone: periosteal perimeter 13.0 23 2 4.5 0.95 6.1e-47 Rab11fip2 Cacul1 Dennd10 Grk5 Acsl5 Habp2 Nrap Nhlrc2 Afap1l2 Fhip2a Trub1 Atrnl1 AABR07007068.1 Nanos1 Dclre1a Zfp950 Ces2c Sfxn4 AABR07007032.1 Tcf7l2 Rpap3 Casp7 NA
Bone: post-yield work 13.8 8 0 0.0 1.00 1.6e-29 Efemp2 Naaladl1 Sac3d1 Snx15 Scyl1 Snx32 Ehbp1l1 NA
Bone: stiffness 16.0 2 0 0.0 0.00 1.0e+00 Ccdc57 Rpap3
Bone: trabecular thickness 14.8 5 0 0.0 1.00 6.7e-12 Rab11fip2 Cacul1 Grk5 Nanos1 Sfxn4
Cu content in liver 15.5 1 0 0.0 0.00 1.0e+00 Hoxb9

chisq ratio: Average Chi2 statistic for the selected genes in the secondary trait, divided by the average statistic for all genes in the secondary trait. # genes+: Shared significant genes at Bonferroni correction. # genes++: Shared significant genes at transcriptome-wide significance. % genes++: Number of [++] genes as a percentage of primary trait’s total joint genes. corr: Correlation of effect sizes across the [+] genes.

Associations by panel

tissue modality # hits % hits/tests avg chisq
Adipose alternative polyA 24 1.13 3.3
Adipose alternative TSS 8 0.50 3.0
Adipose gene expression 44 0.53 3.2
Adipose isoform ratio 19 0.67 3.2
Adipose intron excision ratio 14 0.48 2.8
Adipose mRNA stability 18 0.52 3.1
BLA alternative polyA 9 0.75 3.3
BLA alternative TSS 6 0.71 3.0
BLA gene expression 39 0.64 3.3
BLA isoform ratio 19 1.08 3.4
BLA intron excision ratio 15 0.50 3.2
BLA mRNA stability 11 0.54 3.4
Brain alternative polyA 17 0.85 3.2
Brain alternative TSS 19 1.11 3.0
Brain gene expression 51 0.56 3.3
Brain isoform ratio 31 0.98 3.3
Brain intron excision ratio 23 0.43 3.2
Brain mRNA stability 22 0.50 3.1
Eye alternative polyA 4 2.23 3.4
Eye alternative TSS 2 0.83 2.8
Eye gene expression 12 1.07 3.4
Eye isoform ratio 2 0.56 3.6
Eye intron excision ratio 5 0.82 3.1
Eye mRNA stability 3 1.29 3.7
IL alternative polyA 1 0.16 3.2
IL alternative TSS 0 0.00 3.2
IL gene expression 22 0.60 3.3
IL isoform ratio 2 0.25 3.1
IL intron excision ratio 2 0.21 3.1
IL mRNA stability 8 0.72 3.3
LHb alternative polyA 2 0.35 3.0
LHb alternative TSS 0 0.00 2.6
LHb gene expression 28 0.87 3.4
LHb isoform ratio 1 0.13 2.9
LHb intron excision ratio 0 0.00 2.9
LHb mRNA stability 11 1.06 3.3
Liver alternative polyA 15 1.00 3.4
Liver alternative TSS 14 0.92 3.1
Liver gene expression 51 0.71 3.2
Liver isoform ratio 19 0.80 3.3
Liver intron excision ratio 22 0.50 3.0
Liver mRNA stability 21 0.86 3.3
NAcc alternative polyA 11 0.84 3.5
NAcc alternative TSS 11 1.19 3.2
NAcc gene expression 42 0.67 3.4
NAcc isoform ratio 18 0.96 3.6
NAcc intron excision ratio 10 0.33 3.2
NAcc mRNA stability 11 0.49 3.3
OFC alternative polyA 0 0.00 3.4
OFC alternative TSS 1 0.31 3.5
OFC gene expression 24 0.65 3.4
OFC isoform ratio 2 0.25 3.2
OFC intron excision ratio 4 0.40 3.3
OFC mRNA stability 7 0.65 3.4
PL alternative polyA 12 0.84 3.4
PL alternative TSS 10 0.85 3.1
PL gene expression 55 0.74 3.3
PL isoform ratio 14 0.63 3.4
PL intron excision ratio 18 0.50 3.3
PL mRNA stability 12 0.41 3.2

avg chisq: Average Chi2 (squared Z-score) across all models in this panel for this trait.