BMI with tail

Tags: Physiology · Weight

23 loci · 51 genes with independent associations · 601 total associated genes

Significant Loci

#	Chr	Start pos	End pos	# assoc genes	# joint models	Best TWAS P	Best GWAS P	Cond GWAS P	Joint genes
1	chr1	163118025	164452706	1	1	1.72e-10	1.16e-04	1.00e+00	C1h11orf16
2	chr1	201865024	205361167	54	1	1.97e-09	1.08e-08	2.99e-01	Pcnx3
3	chr1	253471624	260518987	102	6	4.13e-35	1.80e-35	1.00e+00	Cacul1 Eno4 LOC102550729 Sfxn4 Tcf7l2
4	chr2	117887529	119716369	8	3	4.36e-08	8.09e-08	1.00e+00	Mccc1 Zfp267
5	chr2	123846334	125075599	1	1	1.94e-09	2.72e-05	3.31e-01	Jade1
6	chr3	129261795	132693612	60	10	7.02e-12	1.30e-12	1.00e+00	Dtd1 Kif16b LOC102550304 LOC120101719 Otor Pcsk2 Rbbp9 Rrbp1 Snrpb2
7	chr5	101140515	102530159	1	1	2.15e-07	2.40e-07	2.53e-01	LOC120102905
8	chr7	138891	2057232	110	5	9.49e-09	1.23e-08	1.00e+00	Cnpy2 Dnajc14 Ormdl2 Prim1 Timeless
9	chr7	5763246	9164704	6	1	3.85e-08	2.55e-07	9.38e-02	Mfsd12
10	chr7	81443452	82946275	3	1	5.64e-09	9.11e-11	1.00e+00	Trps1
11	chr7	117926546	119313462	1	1	1.34e-07	1.01e-06	3.00e-01	Tafa5
12	chr8	72966755	74474378	9	1	1.92e-08	2.29e-07	4.45e-01	Pygo1
13	chr8	76057439	77450698	1	1	2.17e-07	7.01e-06	2.07e-01	Hmgcll1
14	chr8	77931536	79326510	1	1	2.28e-07	2.98e-07	1.31e-01	Gclc
15	chr8	95378367	97639823	19	2	1.17e-09	4.05e-09	1.00e+00	PCOLCE2 Pls1
16	chr8	108585012	109845634	1	1	5.55e-15	4.50e-02	1.35e-01	Klhdc8b
17	chr9	65337960	67262437	17	1	2.70e-08	3.33e-08	1.00e+00	Cryga
18	chr9	75969545	77365260	1	1	1.75e-07	5.00e-01	1.00e+00	Zfand2b
19	chr10	79187722	82873218	164	8	3.22e-18	1.66e-17	1.00e+00	Col1a1 Gngt2 LOC102546598 LOC120095179 Snf8 Tbkbp1
20	chr10	91963188	96071622	16	1	9.40e-09	4.96e-09	1.00e+00	Apoh
21	chr14	34177603	35456143	1	1	2.30e-11	1.42e-03	8.97e-10	Ociad2
22	chr18	25427994	26946372	22	1	9.93e-10	4.29e-08	9.51e-02	Reep5
23	chr20	53722628	54429288	2	1	3.60e-18	7.13e-02	1.00e+00	LOC103694460

Pleiotropic Associations

Trait	Chi² ratio	# genes⁺	# genes⁺⁺	% genes⁺⁺	Corr	Corr P	Genes
BMI without tail	15.05	35	18	35.3	0.98	3.90e-126	Arsg C1h11orf16 Cacul1 Cep112 Ces2c Dennd10 Dstn Emx2os Epb41l4a Fam204a Grk5 Hspa12a Kif16b Klhdc8b LOC102548590 LOC102550729 LOC120100068 LOC120101717 LOC120101719 Nanos1 Otor Pcsk2 Pls1 Prdx3 Prlhr Rab11fip2 Rrbp1 Sec23b Sfxn4 Snrpb2 Trpc1 Trps1 U2surp Zfand2b Zfp950
Body weight	13.06	115	90	176.5	0.99	0.00e+00	Ablim1 Acsl5 Afap1l2 Amz2 Apc Apoh Arsg Atp11b Atp1b3 Atrnl1 Axin2 Brd8 Cacul1 Casp7 Ccdc186 Ccpg1 Cd99 Cdc23 Cep112 Ces2c Cox8a Dclre1a Dennd10 Dnaaf4 Dstn Dtd1 Dzank1 Ehbp1l1 Emx2os Eno4 Epb41l4a Fam13b Fam204a Fermt3 Fhip2a Flrt1 Gclc Gfra1 Gpam Grk5 Gucy2g Habp2 Hmgcll1 Hspa12a Jade1 Kcnk4 Kif16b Kif20a Klhdc8b LOC102547573 LOC102548590 LOC102550112 LOC102550304 LOC102550729 LOC103694460 LOC120095197 LOC120095201 LOC120100065 LOC120100068 LOC120101717 LOC120101719 Macrod1 Map2k6 Mccc1 Naaladl1 Nanos1 Nhlrc2 Nme5 Nrap Otor Otub1 Ovol1 PCOLCE2 Pcsk2 Pigb Pkd2l2 Plekhs1 Pls1 Polr3f Prdx3 Prlhr Pygo1 Rab11fip2 Rbbp9 Reep5 Rpl37-ps2 Rps6ka4 Rrbp1 Rtn3 Sac3d1 Sec23b Sfxn4 Slc16a6 Smim26 Snrpb2 Snx15 Snx32 Srp19 Syvn1 Tafa5 Tbkbp1 Tcf7l2 Tectb Tfdp2 Trpc1 Trps1 Trub1 U2surp Wipi1 Xrn1 Zdhhc6 Zfp133 Zfp267 Zfp950 Znrd2
Epididymis fat weight	19.4	59	45	88.2	0.98	6.46e-222	Ablim1 Acsl5 Afap1l2 Amz2 Apoh Arsg Atrnl1 Axin2 Cacul1 Casp7 Ccdc186 Cep112 Ces2c Dclre1a Dennd10 Dstn Emx2os Eno4 Fam204a Fhip2a Gfra1 Gpam Grk5 Gucy2g Habp2 Hspa12a Kif16b LOC102547573 LOC102550112 LOC102550304 LOC102550729 LOC120095201 LOC120100065 LOC120100068 LOC120101717 LOC120101719 Nanos1 Nhlrc2 Nrap Otor Pcsk2 Plekhs1 Prdx3 Prlhr Rab11fip2 Rbbp9 Rrbp1 Sec23b Sfxn4 Slc16a6 Snrpb2 Tcf7l2 Tectb Trub1 Wipi1 Zdhhc6 Zfand2b Zfp133 Zfp950
Heart weight	20.2	5	1	2	0.86	6.54e-03	Cacul1 Emx2os Klhdc8b Sfxn4 Zfand2b
Left kidney weight	11.64	24	18	35.3	0.98	1.34e-65	Acsl5 Cacul1 Cd99 Ces2c Dennd10 Emx2os Fam204a Gpam Grk5 Gucy2g Klhdc8b LOC102550729 LOC103694460 LOC120100068 Nanos1 Ociad2 Prdx3 Prlhr Rab11fip2 Sfxn4 Tafa5 Trpc1 Zfand2b Zfp950
Right kidney weight	10.32	37	18	35.3	0.97	1.79e-82	Ablim1 Acsl5 Afap1l2 Atrnl1 Cacul1 Casp7 Ccdc186 Cd99 Ces2c Dclre1a Dennd10 Emx2os Fam204a Fhip2a Gpam Grk5 Gucy2g Habp2 Klhdc8b LOC102550729 LOC103694460 LOC120100068 Nanos1 Nhlrc2 Nrap Ociad2 Plekhs1 Prdx3 Prlhr Rab11fip2 Sfxn4 Tafa5 Tectb Trub1 U2surp Zfand2b Zfp950
Tail length	11.63	61	39	76.5	-0.99	0.00e+00	Abi3 Apof Atp5mc1 B4galnt2 Calcoco2 Cbx1 Cdk5rap3 Cnpy2 Copz2 Cryga Crygc Dgka Dnajc14 Erbb3 Gip Gls2 Gngt2 Hoxb2 Hoxb3 Hoxb4 Hoxb7 Hoxb9 Hsd17b6 Il23a Klhdc8b Kpnb1 LOC102546598 LOC102547047 LOC102547278 LOC102547955 LOC102550580 LOC108352124 LOC120093525 LOC120095179 LOC120095180 Lrrc46 Mrpl10 Myl6 Nfe2l1 Osbpl7 Phb1 Phospho1 Pnpo Prim1 Prr15l Ptges3 Rbms2 Rnf41 Sarnp Scrn2 Skap1 Smarcc2 Snf8 Snx11 Sp2 Spop Stat2 Timeless Ube2z Zfand2b Zfp652
Length with tail	7.25	56	35	68.6	-0.93	1.66e-174	Abi3 Atp5mc1 B4galnt2 Cacul1 Calcoco2 Cbx1 Ccnyl1 Cdk5rap3 Copz2 Cryga Crygc Fam237a Fzd5 Gip Gngt2 Hoxb2 Hoxb3 Hoxb4 Hoxb7 Hoxb9 Idh1 Kif16b Klhdc8b Kpnb1 LOC102546598 LOC102547047 LOC102547278 LOC102547955 LOC102550580 LOC108352124 LOC120094695 LOC120095179 LOC120095180 Lrrc46 Mettl21a Mrpl10 Nfe2l1 Osbpl7 Otor Phb1 Phospho1 Pikfyve Plekhm3 Pnpo Prr15l Scrn2 Sfxn4 Skap1 Snf8 Snrpb2 Snx11 Sp2 Spop Ube2z Zfand2b Zfp652
Length without tail	13.13	8	1	2	0.83	2.34e-04	Acsl5 Cacul1 Casp7 Emx2os Grk5 Habp2 Prlhr Zfand2b
Liver weight, left	11.57	6	0	0	0.54	2.14e-01	C1h11orf16 Cacul1 Grk5 Klhdc8b LOC103694460 Prlhr
Liver weight, right	13.27	18	7	13.7	0.95	1.05e-25	Acsl5 Cacul1 Casp7 Cd99 Dennd10 Fam204a Gpam Grk5 Habp2 LOC103694460 Nanos1 Plekhs1 Prlhr Rab11fip2 Sfxn4 Zdhhc6 Zfand2b Zfp950
Parametrial fat weight	17.16	53	30	58.8	0.99	2.67e-252	Ablim1 Acsl5 Afap1l2 Atrnl1 Cacul1 Casp7 Ccdc186 Ces2c Dclre1a Dennd10 Dstn Dtd1 Dzank1 Emx2os Eno4 Fam204a Fhip2a Gfra1 Gpam Grk5 Gucy2g Habp2 Hspa12a Kif16b LOC102547573 LOC102550304 LOC102550729 LOC120100065 LOC120100068 LOC120101717 LOC120101719 Nanos1 Nhlrc2 Nrap Otor Pcsk2 Plekhs1 Polr3f Prdx3 Prlhr Rab11fip2 Rbbp9 Rrbp1 Sec23b Sfxn4 Smim26 Snrpb2 Tcf7l2 Trub1 Zdhhc6 Zfand2b Zfp133 Zfp950
Retroperitoneal fat weight	22.54	66	55	107.8	0.99	0.00e+00	Ablim1 Acsl5 Afap1l2 Amz2 Apoh Arsg Atrnl1 Axin2 Cacul1 Casp7 Ccdc186 Cd99 Cep112 Ces2c Dclre1a Dennd10 Dstn Dtd1 Dzank1 Emx2os Eno4 Fam204a Fhip2a Gfra1 Gpam Grk5 Gucy2g Habp2 Hspa12a Kif16b Klhdc8b LOC102547573 LOC102550112 LOC102550304 LOC102550729 LOC103694460 LOC120095201 LOC120100065 LOC120100068 LOC120101717 LOC120101719 Nanos1 Nhlrc2 Nrap Otor Pcsk2 Plekhs1 Polr3f Prdx3 Prlhr Rab11fip2 Rbbp9 Rrbp1 Sec23b Sfxn4 Slc16a6 Smim26 Snrpb2 Tcf7l2 Tectb Trub1 Wipi1 Zdhhc6 Zfand2b Zfp133 Zfp950
Intraocular pressure	38.04	2	2	3.9	0	1.00e+00	LOC103694460 Zfand2b
Extensor digitorum longus weight	5.76	71	11	21.6	1	4.97e-263	Apof Atp11b Atp5f1b Baz2a Bloc1s1 Ccpg1 Cdk2 Cnpy2 Coq10a Cox8a Cs Dgka Dnaaf4 Dnajc14 Ehbp1l1 Erbb3 Fermt3 Gls2 Hsd17b6 Ikzf4 Itga7 Jade1 Kcnk4 LOC102546625 LOC102549817 LOC102551925 LOC102556486 LOC103692757 LOC103694460 LOC108350028 LOC120093525 LOC120093754 LOC130046242 Macrod1 Mccc1 Mfsd12 Myl6 Nabp2 Naca Ormdl2 Otub1 Ovol1 Pan2 Pcnx3 Pigb Prim1 Ptges3 Pygo1 Rbms2 Rdh5 RGD1562465 Rnf41 Rpl37-ps2 Rps6ka4 Rtn3 Sac3d1 Sarnp Sirt6 Smarcc2 Snx15 Snx32 Stat2 Suox Syvn1 Tbkbp1 Tfdp2 Timeless Tmem198b Zc3h10 Zfp267 Znrd2
Soleus weight	7.3	55	8	15.7	0.99	3.76e-170	Ablim1 Acsl5 Apof Atrnl1 Bloc1s1 Ccpg1 Cdk2 Cnpy2 Coq10a Cs Dgka Dnaaf4 Dnajc14 Emx2os Erbb3 Gls2 Gpam Grk5 Gucy2g Habp2 Hsd17b6 Ikzf4 Itga7 Klhdc8b LOC102546625 LOC102549817 LOC102551925 LOC103692757 LOC120093525 LOC120093754 LOC120100068 LOC130046242 Matk Mfsd12 Myl6 Nabp2 Ormdl2 Pan2 Pigb Prim1 Ptges3 Pygo1 Rbms2 Rdh5 Rnf41 Sarnp Sirt6 Smarcc2 Stat2 Suox Tectb Timeless Tmem198b Trub1 Zc3h10
Tibialis anterior weight	8.25	22	9	17.6	0.99	1.33e-35	Atp11b Ccpg1 Cox8a Dnaaf4 Fermt3 Gclc Jade1 Kcnk4 LOC103694460 Macrod1 Mccc1 Otub1 Pigb Pygo1 Rps6ka4 Rtn3 Sac3d1 Snx15 Snx32 Syvn1 Zfp267 Znrd2
Tibia length	7.6	6	1	2	1	9.52e-18	Kif16b Klhdc8b LOC120101717 Ociad2 Otor Snrpb2
Number of licking bursts	28.51	2	2	3.9	0	1.00e+00	Klhdc8b Zfand2b
Food consumed during 24 hour testing period	15.78	1	0	0	0	1.00e+00	Zfand2b
Mean num. licks in bursts	18.13	1	0	0	0	1.00e+00	Zfand2b
Water consumed over 24 hours	34.33	1	1	2	0	1.00e+00	Zfand2b
Patch foraging indifference point 0 sec	12.38	2	0	0	0	1.00e+00	LOC103694460 Zfand2b
Patch foraging indifference point AUC	24.2	1	1	2	0	1.00e+00	Zfand2b
Indifference point function ln k	35.82	3	2	3.9	0	1.00e+00	Klhdc8b Ociad2 Zfand2b
Indifference point function log k	35.82	3	2	3.9	0	1.00e+00	Klhdc8b Ociad2 Zfand2b
Patch foraging total patch changes 0 sec	15.52	3	1	2	0	1.00e+00	LOC103694460 Prlhr Zfand2b
Patch foraging total patch changes 18 sec	30.97	2	1	2	0	1.00e+00	Ociad2 Zfand2b
Patch foraging total patch changes 24 sec	45.89	2	1	2	0	1.00e+00	Ociad2 Zfand2b
Patch foraging total patch changes 6 sec	16.36	3	1	2	0	1.00e+00	Fhip2a LOC120102905 Zfand2b
Patch foraging time to switch 0 sec	33.47	1	1	2	0	1.00e+00	Zfand2b
Patch foraging water rate 0 sec	39.47	1	1	2	0	1.00e+00	Zfand2b
Patch foraging water rate 12 sec	17.89	8	1	2	-0.53	1.17e-01	Ehbp1l1 Ovol1 Rps6ka4 Sac3d1 Snx15 Snx32 Zfand2b Znrd2
Patch foraging water rate 24 sec	12.61	1	0	0	0	1.00e+00	Zfand2b
Patch foraging water rate 6 sec	35.43	1	1	2	0	1.00e+00	Zfand2b
Locomotor activity	35.08	2	1	2	0	1.00e+00	Klhdc8b Zfand2b
Locomotor testing distance	55.86	2	2	3.9	0	1.00e+00	Klhdc8b Zfand2b
Locomotor testing rearing	99.51	1	1	2	0	1.00e+00	Zfand2b
Light reinforcement 1	19.25	1	1	2	0	1.00e+00	Zfand2b
Reaction time number correct	66.72	2	2	3.9	0	1.00e+00	Klhdc8b Zfand2b
Reaction time mean minus median	98.07	2	1	2	0	1.00e+00	C1h11orf16 Zfand2b
Reaction time mean minus median AUC	122.84	2	1	2	0	1.00e+00	C1h11orf16 Zfand2b
Reaction time num false alarms	17.2	1	0	0	0	1.00e+00	Ociad2
Reaction time num false alarms AUC	27.43	1	1	2	0	1.00e+00	Zfand2b
Reaction time trials correct on left	66.72	2	2	3.9	0	1.00e+00	Klhdc8b Zfand2b
Reaction time trials on left	63.1	2	2	3.9	0	1.00e+00	Klhdc8b Zfand2b
Reaction time mean	36.11	1	1	2	0	1.00e+00	Zfand2b
Reaction time mean AUC	33.75	1	1	2	0	1.00e+00	Zfand2b
Median of all reaction times	17.65	1	0	0	0	1.00e+00	Zfand2b
Reaction time omissions	27.35	4	3	5.9	-0.66	3.44e-01	Jade1 Klhdc8b Ociad2 Zfand2b
Reaction time false alarm rate	20.24	1	1	2	0	1.00e+00	Klhdc8b
Reaction time premature initiations	41.6	1	1	2	0	1.00e+00	Zfand2b
Std. dev. reaction times	43.56	2	1	2	0	1.00e+00	Jade1 Zfand2b
Reaction time trials completed	63.1	2	2	3.9	0	1.00e+00	Klhdc8b Zfand2b
Reaction time trials AUC	64.7	2	2	3.9	0	1.00e+00	Klhdc8b Zfand2b
Conditioned locomotion	28.4	1	1	2	0	1.00e+00	Klhdc8b
Cocaine response after cond. not corrected	16.6	1	0	0	0	1.00e+00	Klhdc8b
Cocaine response before conditioning	38.66	1	1	2	0	1.00e+00	Klhdc8b
Condit. Reinf. active responses	14.98	4	0	0	0.88	1.23e-01	Epb41l4a Fam13b Ociad2 Reep5
Condit. Reinf. lever reinforcers received	13.58	3	0	0	0	1.00e+00	Fam13b Ociad2 Reep5
Pavlov. Cond. index score	15.43	1	0	0	0	1.00e+00	LOC103694460
Pavlov. Cond. magazine entry number	25.13	2	1	2	0	1.00e+00	Klhdc8b LOC103694460
Pavlov. Cond. response bias	13.13	1	0	0	0	1.00e+00	LOC103694460
Conditioned reinforcement - actives	152.54	1	1	2	0	1.00e+00	Zfand2b
Conditioned reinforcement - inactives	76.2	2	1	2	0	1.00e+00	Klhdc8b Zfand2b
Intermittent access intake day 1-15 change	156.77	1	1	2	0	1.00e+00	Zfand2b
Intermittent access intake escalation	117.41	1	1	2	0	1.00e+00	Zfand2b
Intermittent access intake escalation 2	17.78	1	0	0	0	1.00e+00	C1h11orf16
Intermitt. access day 1 inactive lever presses	169.63	1	1	2	0	1.00e+00	Zfand2b
Intermitt. access day 15 inactive lever presses	162.52	2	2	3.9	0	1.00e+00	Klhdc8b Zfand2b
Intermitt. access escalation Index	38.02	1	1	2	0	1.00e+00	Ociad2
Intermittent access day 1 total infusions	71.42	1	1	2	0	1.00e+00	Zfand2b
Intermittent access day 15 total infusions	35.39	1	1	2	0	1.00e+00	Zfand2b
Intermittent access terminal intake (last 3 days)	24.92	2	1	2	0	1.00e+00	Klhdc8b Zfand2b
Intermittent access total infusions	15.45	1	0	0	0	1.00e+00	Klhdc8b
Intermittent access day 1 locomotion	26.47	1	1	2	0	1.00e+00	Zfand2b
Intermittent access day 15 total locomotion	93.08	1	1	2	0	1.00e+00	Zfand2b
Intermittent access standard deviation	229.66	2	1	2	0	1.00e+00	Klhdc8b Zfand2b
Cocaine induced anxiety	125.35	1	1	2	0	1.00e+00	Zfand2b
Post-drug Anxiety	21.14	1	0	0	0	1.00e+00	Ociad2
Baseline Anxiety	393.92	1	1	2	0	1.00e+00	Zfand2b
Incentive Sensitization - Responses	309.83	1	1	2	0	1.00e+00	Zfand2b
Incentive Sensitization - Breakpoint	300.45	1	1	2	0	1.00e+00	Zfand2b
Progressive ratio test 1 active lever presses	26.41	1	1	2	0	1.00e+00	Zfand2b
Progressive ratio test 1 breakpoint	19.19	1	0	0	0	1.00e+00	Zfand2b
Progressive ratio test 1 inactive lever presses	16.55	1	0	0	0	1.00e+00	Klhdc8b
Progressive ratio test 2 active lever presses	109.22	1	1	2	0	1.00e+00	Zfand2b
Progressive ratio test 2 breakpoint	106.65	1	1	2	0	1.00e+00	Zfand2b
Progressive ratio test 2 inactive lever presses	63.47	1	1	2	0	1.00e+00	Zfand2b
Total sessions with >9 infusions	16	1	0	0	0	1.00e+00	Klhdc8b
Short access day 1 total inactive lever presses	21.93	1	0	0	0	1.00e+00	Zfand2b
Short access day 10 total inactive lever presses	72.35	2	2	3.9	0	1.00e+00	Klhdc8b Zfand2b
Short access day 1 locomotion	129.19	1	1	2	0	1.00e+00	Zfand2b
Short access day 10 total locomotion	432.47	1	1	2	0	1.00e+00	Zfand2b
Short access total locomotion	209.96	1	1	2	0	1.00e+00	Zfand2b
Compulsive drug intake	68.39	1	1	2	0	1.00e+00	Zfand2b
One hour access (0.3 mA shock)	22.58	1	0	0	0	1.00e+00	Zfand2b
Number of responses in last shaping day	67.75	1	1	2	0	1.00e+00	Zfand2b
Locomotion distance, session 1	23.98	1	1	2	0	1.00e+00	Klhdc8b
Locomotion distance, session 2	33.15	1	1	2	0	1.00e+00	Klhdc8b
Locomotion velocity, session 3	17.14	1	0	0	0	1.00e+00	Klhdc8b
Locomotion distance, session 8	52.78	1	1	2	0	1.00e+00	Klhdc8b
Degree of sensitization distance	24.75	1	0	0	0	1.00e+00	Klhdc8b
Condit. Reinf. active minus inactive responses	35.59	1	1	2	0	1.00e+00	Klhdc8b
Condit. Reinf. active-inactive response ratio	25.6	1	1	2	0	1.00e+00	Klhdc8b
Condit. Reinf. active responses	18.23	1	0	0	0	1.00e+00	Klhdc8b
Incentive salience index mean	26.23	1	1	2	0	1.00e+00	Klhdc8b
Time in familiar zone, hab. session 1	63.49	1	1	2	0	1.00e+00	Klhdc8b
Total zone transitions, hab. session 1	37.38	1	1	2	0	1.00e+00	Klhdc8b
Time in familiar zone, hab. session 2	27.1	1	1	2	0	1.00e+00	Klhdc8b
Total zone transitions, hab. session 2	69.58	1	1	2	0	1.00e+00	Klhdc8b
Total locomotion distance, hab. session 2	19.2	1	0	0	0	1.00e+00	Klhdc8b
Locomotion velocity, hab. session 2	21.15	1	1	2	0	1.00e+00	Klhdc8b
Novel to familiar place preference ratio	22.33	1	0	0	0	1.00e+00	Klhdc8b
Novelty place preference	20.99	1	0	0	0	1.00e+00	Klhdc8b
Time in novel zone, NPP test	17.06	1	0	0	0	1.00e+00	Klhdc8b
Total zone transitions, NPP test	23.4	5	1	2	0.94	1.97e-04	Klhdc8b PCOLCE2 Pls1 Trpc1 U2surp
Total locomotion distance, NPP test	47.64	1	1	2	0	1.00e+00	Klhdc8b
Locomotion velocity, NPP test	51.12	1	1	2	0	1.00e+00	Klhdc8b
Pavlov. Cond. change in total contacts	69.48	1	1	2	0	1.00e+00	Klhdc8b
Pavlov. Cond. index score	14.07	1	0	0	0	1.00e+00	Klhdc8b
Pavlov. Cond. lever-magazine prob. diff.	14.82	1	0	0	0	1.00e+00	Klhdc8b
Bone volume	10.02	2	0	0	0	1.00e+00	Cacul1 Grk5
Bone: cortical apparent density	15.5	1	0	0	0	1.00e+00	C1h11orf16
Bone: cortical area	13.31	26	0	0	0.97	4.57e-63	Ablim1 Acsl5 Afap1l2 Cacul1 Casp7 Ccdc186 Ces2c Dclre1a Dennd10 Emx2os Fam204a Fhip2a Gfra1 Grk5 Habp2 LOC102547573 LOC102550729 LOC120100065 LOC120100068 Nhlrc2 Plekhs1 Prlhr Rab11fip2 Sfxn4 Trub1 Zfp950
Bone: cortical porosity	16.96	1	0	0	0	1.00e+00	LOC103694460
Bone: cortical thickness	11.62	6	0	0	0.93	1.06e-04	Emx2os Fam204a LOC120100068 Prlhr Rab11fip2 Zfp950
Bone: cortical tissue density	16.13	1	0	0	0	1.00e+00	C1h11orf16
Bone: endosteal perimeter	14.86	3	1	2	0	1.00e+00	Ablim1 Cd99 LOC103694460
Bone: final force	11.01	7	0	0	0.99	3.11e-14	Cacul1 Emx2os Grk5 Prlhr Rab11fip2 Sfxn4 Zfp950
Bone: final moment	11.67	6	0	0	1	5.48e-18	Cacul1 Grk5 Prlhr Rab11fip2 Sfxn4 Zfp950
Bone: maximum diameter	10.95	18	1	2	0.99	4.04e-40	Ablim1 Acsl5 Afap1l2 Cacul1 Casp7 Ccdc186 Cd99 Dclre1a Fhip2a Gfra1 Habp2 LOC102547573 LOC103694460 LOC120100065 Nhlrc2 Nrap Plekhs1 Trub1
Bone: maximum force	10.64	6	0	0	1	1.62e-11	Cacul1 Grk5 Prlhr Rab11fip2 Sfxn4 Zfp950
Bone: maximum moment	11.11	6	0	0	1	3.40e-14	Cacul1 Grk5 Prlhr Rab11fip2 Sfxn4 Zfp950
Bone: minimum diameter	9.23	3	0	0	0	1.00e+00	Cacul1 LOC103694460 Ociad2
Bone: periosteal estimation	9.12	16	0	0	0.98	8.89e-34	Acsl5 Cacul1 Casp7 Ces2c Dennd10 Emx2os Fam204a Grk5 Habp2 LOC120100065 Nhlrc2 Plekhs1 Prlhr Rab11fip2 Sfxn4 Zfp950
Bone: periosteal perimeter	13.14	27	3	5.9	0.95	1.58e-65	Ablim1 Acsl5 Afap1l2 Atrnl1 Cacul1 Casp7 Ccdc186 Ces2c Dclre1a Dennd10 Fam204a Fhip2a Gfra1 Grk5 Habp2 LOC102547573 LOC102550729 LOC103694460 LOC120100065 Nhlrc2 Nrap Plekhs1 Prlhr Rab11fip2 Sfxn4 Trub1 Zfp950
Bone: post-yield work	13.79	9	0	0	1	8.89e-24	Arl2 Capn1 Fosl1 Naaladl1 Sac3d1 Scyl1 Sipa1 Snx15 Snx32
Bone: stiffness	13.41	1	0	0	0	1.00e+00	Klhdc8b
Bone: trabecular number	11.4	1	0	0	0	1.00e+00	C1h11orf16
Bone: trabecular spacing	15.64	1	0	0	0	1.00e+00	C1h11orf16
Bone: trabecular thickness	15.7	5	0	0	1	1.06e-12	Cacul1 Grk5 Prlhr Sfxn4 Zfp950
Distance traveled before self-admin	17.44	1	0	0	0	1.00e+00	C1h11orf16
Delta time in open arm before/after self-admin	26.67	1	0	0	0	1.00e+00	Zfand2b
Active lever presses in extinction session 6	26.41	1	0	0	0	1.00e+00	Zfand2b
Time in closed arm before self-admin	44.32	1	1	2	0	1.00e+00	Zfand2b
Time in open arm before self-admin	24.67	1	0	0	0	1.00e+00	Zfand2b
Time to tail flick, vehicle, after self-admin	56.6	2	2	3.9	0	1.00e+00	Klhdc8b Zfand2b
Delta time to tail flick, vehicle, before/after SA	74.6	1	1	2	0	1.00e+00	Zfand2b
Ambulatory time before self-admin	25.36	1	0	0	0	1.00e+00	Zfand2b
Total heroin consumption	18.89	1	0	0	0	1.00e+00	Klhdc8b
Area under the delay curve	31.15	1	1	2	0	1.00e+00	Zfand2b
Delay disc. indifference point, 0s delay	28.7	1	1	2	0	1.00e+00	Klhdc8b
Delay disc. indifference point, 16s delay	69.03	1	1	2	0	1.00e+00	Zfand2b
Delay disc. indifference point, 24s delay	27.43	1	0	0	0	1.00e+00	Zfand2b
Delay disc. indifference point, 4s delay	41.82	1	1	2	0	1.00e+00	Klhdc8b
Delay disc. indifference point, 8s delay	74.24	1	1	2	0	1.00e+00	Zfand2b
Delay discount exponential model param	16.14	1	0	0	0	1.00e+00	Zfand2b
Delay discount hyperbolic model param	15.89	1	0	0	0	1.00e+00	Zfand2b
Fecal boli incidents, locomotor time 1	96.73	2	1	2	0	1.00e+00	Klhdc8b Zfand2b
Time >=10cm from walls, locomotor time 1	79.04	1	1	2	0	1.00e+00	Zfand2b
Rest time, locomotor task time 1	22.55	1	0	0	0	1.00e+00	Klhdc8b
Distance moved, locomotor task time 1	31.01	1	1	2	0	1.00e+00	Klhdc8b
Vertical activity count, locomotor time 1	73.36	2	2	3.9	0	1.00e+00	Klhdc8b Zfand2b
Bouts of movement, locomotor time 2	21.88	2	0	0	0	1.00e+00	Klhdc8b Zfand2b
Total resting periods, locomotor time 2	28.25	2	1	2	0	1.00e+00	Klhdc8b Zfand2b
Rest time, locomotor task time 2	35.13	2	2	3.9	0	1.00e+00	Klhdc8b Zfand2b
Distance moved, locomotor task time 2	63.13	2	2	3.9	0	1.00e+00	Klhdc8b Zfand2b
Vertical activity count, locomotor time 2	54.92	1	1	2	0	1.00e+00	Klhdc8b
Weight adjusted by age	30.32	1	1	2	0	1.00e+00	Klhdc8b
Seeking ratio, delayed vs. immediate footshock	18.76	1	0	0	0	1.00e+00	C1h11orf16
Locomotion in novel chamber post-restriction	14.04	1	0	0	0	1.00e+00	Zfand2b
Food seeking constrained by brief footshock	15.76	2	0	0	0	1.00e+00	LOC120102905 Zfand2b
Run reversals in cocaine runway, females	36.45	1	1	2	0	1.00e+00	Zfand2b
Latency to leave start box in cocaine runway	34.23	1	1	2	0	1.00e+00	Zfand2b
Latency to leave start box in cocaine runway, F	31.9	1	1	2	0	1.00e+00	Zfand2b
Latency to leave start box in cocaine runway, M	55.97	1	1	2	0	1.00e+00	C1h11orf16
Cd content in liver	20.17	1	0	0	0	1.00e+00	Klhdc8b
Cu content in liver	23.31	4	1	2	-0.99	7.22e-03	Cd99 LOC103694460 LOC120095179 Snf8
Fe content in liver	33.68	2	2	3.9	0	1.00e+00	Klhdc8b LOC103694460
K content in liver	34.63	2	1	2	0	1.00e+00	Cd99 LOC103694460
Na content in liver	16.36	1	0	0	0	1.00e+00	Klhdc8b
Rb content in liver	54.46	3	3	5.9	0	1.00e+00	Cd99 Klhdc8b LOC103694460
Se content in liver	41.97	1	1	2	0	1.00e+00	Ociad2
Sr content in liver	21.09	3	0	0	0	1.00e+00	Klhdc8b LOC103694460 Ociad2

Associations by panel

Tissue	RNA modality	# hits	% hits/tests	Avg chisq
Adipose	alternative polyA	30	0.8	3.25
Adipose	alternative TSS	18	0.5	3.13
Adipose	gene expression	62	0.7	3.21
Adipose	isoform ratio	29	0.6	3
Adipose	intron excision ratio	17	0.5	2.71
Adipose	mRNA stability	26	0.6	3.17
BLA	alternative polyA	13	0.6	3.31
BLA	alternative TSS	9	0.5	3.55
BLA	gene expression	35	0.5	3.34
BLA	isoform ratio	16	0.5	3.31
BLA	intron excision ratio	14	0.4	3.21
BLA	mRNA stability	13	0.5	3.42
Brain	alternative polyA	11	0.3	3.1
Brain	alternative TSS	26	0.6	3.38
Brain	gene expression	56	0.6	3.27
Brain	isoform ratio	34	0.6	3.29
Brain	intron excision ratio	27	0.5	3.1
Brain	mRNA stability	24	0.4	3.14
Eye	alternative polyA	0	0	3.29
Eye	alternative TSS	4	1	3.52
Eye	gene expression	10	0.8	3.21
Eye	isoform ratio	4	0.7	3.63
Eye	intron excision ratio	6	0.7	2.9
Eye	mRNA stability	0	0	3.2
IL	alternative polyA	4	0.4	3.17
IL	alternative TSS	0	0	3.27
IL	gene expression	21	0.5	3.35
IL	isoform ratio	4	0.3	2.95
IL	intron excision ratio	2	0.2	3.18
IL	mRNA stability	9	0.7	3.54
LHb	alternative polyA	11	1	3.31
LHb	alternative TSS	3	0.5	3.34
LHb	gene expression	24	0.7	3.41
LHb	isoform ratio	6	0.5	2.96
LHb	intron excision ratio	0	0	2.97
LHb	mRNA stability	8	0.6	3.25
Liver	alternative polyA	9	0.3	3.13
Liver	alternative TSS	21	0.8	3.34
Liver	gene expression	45	0.6	3.17
Liver	isoform ratio	22	0.6	3.32
Liver	intron excision ratio	23	0.5	2.99
Liver	mRNA stability	28	0.9	3.26
NAcc	alternative polyA	13	0.4	3.34
NAcc	alternative TSS	7	0.3	3.31
NAcc	gene expression	47	0.6	3.37
NAcc	isoform ratio	23	0.5	3.34
NAcc	intron excision ratio	16	0.3	3.22
NAcc	mRNA stability	20	0.6	3.36
OFC	alternative polyA	11	1	3.43
OFC	alternative TSS	1	0.1	3.71
OFC	gene expression	21	0.5	3.3
OFC	isoform ratio	3	0.2	3.13
OFC	intron excision ratio	6	0.5	3.47
OFC	mRNA stability	9	0.7	3.43
PL	alternative polyA	22	0.7	3.32
PL	alternative TSS	19	0.6	3.31
PL	gene expression	57	0.6	3.31
PL	isoform ratio	28	0.6	3.35
PL	intron excision ratio	33	0.6	3.28
PL	mRNA stability	20	0.5	3.24
pVTA	alternative polyA	4	0.2	3.28
pVTA	alternative TSS	8	0.6	3.39
pVTA	gene expression	34	0.6	3.34
pVTA	isoform ratio	9	0.4	3.15
pVTA	intron excision ratio	10	0.3	3.18
pVTA	mRNA stability	14	1	3.34
RMTg	alternative polyA	2	0.3	2.65
RMTg	alternative TSS	3	0.6	3.47
RMTg	gene expression	12	0.7	3.32
RMTg	isoform ratio	6	0.9	3.24
RMTg	intron excision ratio	4	0.5	2.84
RMTg	mRNA stability	3	0.5	3.16