Hub : Traits

BMI with tail

Tags: Physiology · Weight

Project: dissection

21 loci · 44 genes with independent associations · 186 total associated genes

Significant Loci

#	Chr	Start pos	End pos	# assoc genes	# joint models	Best TWAS P	Best GWAS P	Cond GWAS P	Joint genes
1	1	201865024	205361167	28	4	7.15e-09	1.08e-08	NaN	Ovol1 Slc22a12 Kcnk4 Macrod1
2	1	206890006	208286941	1	1	3.11e-08	2.23e-05	6.64e-01	Ptgdr2
3	1	253445764	260518987	32	7	5.50e-34	1.80e-35	1.00e+00	Rab11fip2 Cacul1 Prdx3 Acsl5 Sfxn4 ENSRNOG00000065260 ENSRNOG00000065957
4	2	117887529	119795716	3	1	1.01e-07	8.09e-08	1.00e+00	Atp11b
5	2	123236866	125075599	2	1	3.66e-09	1.95e-05	8.64e-01	Jade1
6	3	129554891	132693612	14	5	3.81e-12	1.30e-12	1.00e+00	Kif16b Snrpb2 Pcsk2 Dstn Otor
7	7	29535	2057232	29	5	1.23e-08	1.23e-08	1.00e+00	Spryd4 Cnpy2 Dnajc14 Sarnp Timeless
8	7	6571870	7969119	1	1	2.37e-07	2.67e-07	1.00e+00	ENSRNOG00000033583
9	7	81442141	82840708	1	1	8.06e-09	9.11e-11	2.18e-03	Trps1
10	7	117926546	119313462	1	1	4.15e-08	1.01e-06	8.70e-02	Tafa5
11	7	128140829	129538159	1	1	1.36e-07	7.85e-06	9.23e-01	Rpap3
12	8	70127064	71520043	1	1	2.21e-07	7.03e-07	3.07e-20	Fam81a
13	8	72966755	74474378	3	1	1.45e-08	2.29e-07	5.68e-01	Pygo1
14	8	77504998	78898375	1	1	3.33e-07	2.98e-07	5.20e-02	Mlip
15	8	95494368	98183778	7	2	3.12e-09	4.05e-09	1.00e+00	Zbtb38 Trpc1
16	9	65337960	67262437	6	1	1.27e-08	3.33e-08	1.00e+00	Fzd5
17	10	79556862	83093905	37	6	6.31e-17	1.66e-17	1.00e+00	Phospho1 Gip Hoxb9 Zfp652 Pnpo Cdk5rap3
18	10	92588108	95279450	8	1	1.78e-08	4.96e-09	1.00e+00	Prkca
19	10	105499327	106889481	1	1	2.26e-07	5.16e-03	1.19e-01	Ccdc57
20	18	25070927	26946372	8	1	4.00e-10	4.29e-08	7.52e-01	Reep5
21	18	29556452	30949426	1	1	1.35e-07	7.38e-07	1.00e+00	Ndfip1

Pleiotropic Associations

Trait	Chi2 ratio	# genes+	# genes++	% genes++	Corr	Corr P	Genes
BMI without tail	14.31	31	14	31.8	1	2.63e-124	Wipi1 Kif16b Snrpb2 Pcsk2 Dstn Rrbp1 Rbbp9 Sec23b Dtd1 Pdzd8 Rab11fip2 Prlhr Pls1 Cacul1 Dennd10 Prdx3 Grk5 Atp1b3 Reep5 Trps1 Nanos1 Epb41l4a Zfp133 Otor Zfp950 Ces2c Sfxn4 Trpc1 ENSRNOG00000065260 ENSRNOG00000065957 ENSRNOG00000068145
Body weight	12.11	104	78	177.3	0.99	0.00e+00	Amz2 Prkca Apoh Rgs9 Wipi1 Kif16b Snrpb2 Pcsk2 Dstn Mlip Rrbp1 Kat14 Dzank1 Rbbp9 Sec23b Dtd1 Nfe2l1 Pdzd8 Rab11fip2 Prlhr Pls1 Cacul1 Dennd10 Gk5 Prdx3 Tfdp2 Grk5 Atp1b3 Zbtb38 Dcun1d1 Znrd2 Jade1 Qrfpr Gpam Tectb Gucy2g Acsl5 Habp2 Nrap Nhlrc2 Afap1l2 Fhip2a Trub1 Atrnl1 AABR07007068.1 Nme5 Reep5 Brd8 Fam13b Apc Ovol1 Capn1 Naaladl1 Sac3d1 Nrxn2 Slc22a12 Rps6ka4 Kcnk4 Fermt3 Macrod1 Otub1 Rtn3 Arhgap23 Scyl1 Cdc23 Cep112 Trps1 Nanos1 Pkd2l2 Epb41l4a Dclre1a Snx32 Zfp133 Mgme1 Otor Zfp950 AABR07030647.1 Ces2c Sfxn4 Zdhhc6 Ptgdr2 Larp1b Dnajc4 AABR07007032.1 Cdca5 PCOLCE2 Ccdc57 Tcf7l2 Tafa5 Atp11b Rpap3 Ccpg1 Trpc1 Axin2 Ehbp1l1 Casp7 Fam81a Pigb ENSRNOG00000065260 ENSRNOG00000065957 Pygo1 ENSRNOG00000067833 ENSRNOG00000068145 ENSRNOG00000071003
Epididymis fat weight	18.91	50	36	81.8	0.99	2.05e-211	Amz2 Prkca Apoh Rgs9 Wipi1 Kif16b Snrpb2 Pcsk2 Dstn Rrbp1 Rbbp9 Sec23b Pdzd8 Rab11fip2 Prlhr Cacul1 Dennd10 Prdx3 Grk5 Gpam Tectb Gucy2g Acsl5 Habp2 Nrap Nhlrc2 Afap1l2 Fhip2a Trub1 Atrnl1 AABR07007068.1 Cep112 Nanos1 Dclre1a Zfp133 Mgme1 Otor Zfp950 AABR07030647.1 Ces2c Sfxn4 Zdhhc6 AABR07007032.1 Tcf7l2 Axin2 Casp7 ENSRNOG00000065260 ENSRNOG00000065957 ENSRNOG00000068145 ENSRNOG00000071003
Glucose	10.75	2	0	0	0	1.00e+00	Zfp950 Sfxn4
Heart weight	12.54	3	0	0	0	1.00e+00	Cacul1 Nanos1 Sfxn4
Left kidney weight	10.48	21	13	29.5	0.99	9.34e-47	Rab11fip2 Prlhr Cacul1 Dennd10 Prdx3 Grk5 Gpam Gucy2g Acsl5 Nhlrc2 Nanos1 Zfp950 Ces2c Sfxn4 Tcf7l2 Tafa5 Trpc1 ENSRNOG00000065260 ENSRNOG00000065957 ENSRNOG00000068145 ENSRNOG00000071003
Right kidney weight	9.29	30	13	29.5	0.99	2.14e-64	Rab11fip2 Prlhr Cacul1 Dennd10 Prdx3 Grk5 Gpam Gucy2g Acsl5 Habp2 Nrap Nhlrc2 Afap1l2 Fhip2a Trub1 Atrnl1 Nanos1 Dclre1a Zfp950 Ces2c Sfxn4 AABR07007032.1 Tcf7l2 Tafa5 Trpc1 Casp7 ENSRNOG00000065260 ENSRNOG00000065957 ENSRNOG00000068145 ENSRNOG00000071003
Tail length	9.71	59	36	81.8	-1	0.00e+00	Hsd17b6 Ptges3 Atp5f1b Rbms2 Spryd4 Il23a Cnpy2 Spop Pa2g4 Ttll6 Ngfr Phospho1 Abi3 Gip Snf8 Dnajc14 Ube2z Atp5mc1 Hoxb9 Gdf11 Bloc1s1 Hoxb4 Hoxb3 ENSRNOG00000008365 Snx11 Cbx1 Nfe2l1 Copz2 Kpnb1 Osbpl7 Mrpl10 Lrrc46 Scrn2 Sp2 Mrpl45 Mettl21a Zfp652 Kat7 Npepps Rnf41 Cs Sp6 Skap1 Sarnp Stat2 Smarcc2 Gls2 Timeless Prim1 Pnpo Phb Cdk5rap3 Prr15l Myl6 Esyt1 Apof B4galnt2 Atp5mc1 ENSRNOG00000069592
Length with tail	7.29	46	33	75	-0.93	2.73e-98	Spop Ttll6 Kif16b Ngfr Phospho1 Abi3 Gip Snf8 Ube2z Atp5mc1 Hoxb9 Hoxb4 Hoxb3 ENSRNOG00000008365 Snx11 Cbx1 Nfe2l1 Copz2 Kpnb1 Osbpl7 Mrpl10 Lrrc46 Cacul1 Scrn2 Sp2 Mrpl45 Mettl21a Fzd5 Idh1 Pikfyve Zfp652 Kat7 Npepps Sp6 Plekhm3 Skap1 Otor Sfxn4 Cryga Pnpo Phb Cdk5rap3 Prr15l B4galnt2 Atp5mc1 ENSRNOG00000069592
Length without tail	7.9	9	0	0	0.97	2.26e-11	Cacul1 Gpam Gucy2g Acsl5 Habp2 Dclre1a Sfxn4 Tcf7l2 Casp7
Liver weight, left	10.49	2	0	0	1	1.99e-06	Rab11fip2 Cacul1
Liver weight, right	12.65	18	4	9.1	0.98	1.55e-36	Pdzd8 Rab11fip2 Prlhr Cacul1 Grk5 Gpam Tectb Acsl5 Habp2 Nhlrc2 Nanos1 Dclre1a Zfp950 Sfxn4 Zdhhc6 Tcf7l2 Casp7 ENSRNOG00000065260
Parametrial fat weight	17.04	44	27	61.4	0.99	1.12e-161	Kif16b Snrpb2 Pcsk2 Dstn Rrbp1 Kat14 Dzank1 Rbbp9 Sec23b Dtd1 Pdzd8 Rab11fip2 Prlhr Cacul1 Dennd10 Prdx3 Grk5 Gpam Tectb Acsl5 Habp2 Nrap Nhlrc2 Afap1l2 Fhip2a Trub1 Atrnl1 AABR07007068.1 Nanos1 Dclre1a Zfp133 Mgme1 Otor Zfp950 Ces2c Sfxn4 Zdhhc6 AABR07007032.1 Tcf7l2 Casp7 ENSRNOG00000065260 ENSRNOG00000065957 ENSRNOG00000067833 ENSRNOG00000068145
Retroperitoneal fat weight	21.9	54	46	104.5	0.99	3.18e-236	Amz2 Prkca Apoh Rgs9 Wipi1 Kif16b Snrpb2 Pcsk2 Dstn Rrbp1 Kat14 Dzank1 Rbbp9 Sec23b Dtd1 Pdzd8 Rab11fip2 Prlhr Cacul1 Dennd10 Prdx3 Grk5 Gpam Tectb Gucy2g Acsl5 Habp2 Nrap Nhlrc2 Afap1l2 Fhip2a Trub1 Atrnl1 AABR07007068.1 Cep112 Nanos1 Dclre1a Zfp133 Mgme1 Otor Zfp950 AABR07030647.1 Ces2c Sfxn4 Zdhhc6 AABR07007032.1 Tcf7l2 Axin2 Casp7 ENSRNOG00000065260 ENSRNOG00000065957 ENSRNOG00000067833 ENSRNOG00000068145 ENSRNOG00000071003
Extensor digitorum longus weight	5.37	51	21	47.7	1	1.36e-309	Hsd17b6 Ptges3 Atp5f1b Rbms2 Spryd4 Il23a Cnpy2 Pa2g4 Rab5b Tmem198b Dnajc14 Gdf11 Bloc1s1 Itga7 Dcun1d1 Znrd2 Jade1 Qrfpr Ovol1 Sac3d1 Slc22a12 Rps6ka4 Kcnk4 Macrod1 Otub1 Arhgap23 Dgka Rnf41 Cs Snx32 Sarnp Ankrd52 Stat2 Smarcc2 Gls2 Timeless Prim1 Pan2 ENSRNOG00000033583 Ptgdr2 Larp1b Zc3h10 Atp11b Ccpg1 Myl6 Ehbp1l1 Fam81a Pigb Esyt1 Apof Pygo1
Soleus weight	6.97	46	4	9.1	0.99	9.46e-246	Hsd17b6 Ptges3 Atp5f1b Rbms2 Spryd4 Il23a Cnpy2 Pa2g4 Rab5b Tmem198b Dnajc14 Gdf11 Bloc1s1 Itga7 Gpam Tectb Gucy2g Acsl5 Habp2 Fhip2a Trub1 Atrnl1 Dgka Rnf41 Cs Sarnp Ankrd52 Stat2 Smarcc2 Gls2 Timeless Prim1 Pan2 ENSRNOG00000033583 Zc3h10 AABR07007032.1 Tcf7l2 Ccpg1 Myl6 Casp7 Fam81a Pigb Esyt1 Apof ENSRNOG00000065957 Pygo1
Tibialis anterior weight	8.48	20	15	34.1	0.99	1.51e-27	Mlip Dcun1d1 Znrd2 Jade1 Qrfpr Ovol1 Sac3d1 Slc22a12 Kcnk4 Macrod1 Otub1 Snx32 Ptgdr2 Larp1b Atp11b Ccpg1 Ehbp1l1 Fam81a Pigb Pygo1
Tibia length	9.66	4	1	2.3	0.98	1.57e-05	Kif16b Otor Ccdc57 Rpap3
Delay discounting water rate 12 sec	12.57	8	0	0	-1	7.22e-18	Znrd2 Efemp2 Ovol1 Naaladl1 Sac3d1 Slc22a12 Snx32 Ehbp1l1
Std. dev. reaction times	12.12	1	0	0	0	1.00e+00	Jade1
Condit. Reinf. active responses	13.58	3	0	0	0	1.00e+00	Reep5 Fam13b Epb41l4a
Condit. Reinf. lever reinforcers received	13.22	2	0	0	0	1.00e+00	Reep5 Epb41l4a
Total zone transitions, NPP test	12.1	4	0	0	1	2.46e-10	Gk5 Tfdp2 PCOLCE2 Trpc1
Bone surface	10.02	1	0	0	0	1.00e+00	Rpap3
Bone volume	10.29	2	0	0	0	1.00e+00	Cacul1 Sfxn4
Bone: cortical area	13.78	22	1	2.3	0.97	1.30e-39	Rab11fip2 Prlhr Cacul1 Dennd10 Grk5 Acsl5 Habp2 Nhlrc2 Afap1l2 Nanos1 Dclre1a Zfp950 Ces2c Sfxn4 AABR07007032.1 Ccdc57 Tcf7l2 Rpap3 Casp7 ENSRNOG00000065260 ENSRNOG00000065957 ENSRNOG00000068145
Bone: cortical thickness	14.15	5	1	2.3	0.88	1.53e-03	Rab11fip2 Cacul1 Ccdc57 ENSRNOG00000065957 ENSRNOG00000068145
Bone: cortical thickness	21.92	1	0	0	0	1.00e+00	Ccdc57
Bone: elastic work	13.35	1	0	0	0	1.00e+00	Ccdc57
Bone: final force	12.37	9	1	2.3	0.93	1.42e-05	Rab11fip2 Cacul1 Grk5 Nanos1 Zfp950 Sfxn4 Ccdc57 Rpap3 ENSRNOG00000065260
Bone: final moment	12.39	9	1	2.3	0.95	1.96e-08	Rab11fip2 Cacul1 Grk5 Nanos1 Zfp950 Sfxn4 Ccdc57 Rpap3 ENSRNOG00000065260
Bone: maximum diameter	10.6	10	0	0	0.96	2.56e-19	Cacul1 Acsl5 Habp2 Nrap Nhlrc2 Afap1l2 Dclre1a AABR07007032.1 Tcf7l2 Casp7
Bone: maximum force	12.12	8	1	2.3	0.91	9.43e-05	Rab11fip2 Cacul1 Grk5 Zfp950 Sfxn4 Ccdc57 Rpap3 ENSRNOG00000065260
Bone: maximum moment	11.86	8	1	2.3	0.93	1.15e-06	Rab11fip2 Cacul1 Grk5 Zfp950 Sfxn4 Ccdc57 Rpap3 ENSRNOG00000065260
Bone: periosteal estimation	9.42	18	0	0	0.97	3.02e-26	Rab11fip2 Prlhr Cacul1 Dennd10 Grk5 Acsl5 Habp2 Nhlrc2 Nanos1 Dclre1a Zfp950 Ces2c Sfxn4 Ccdc57 Tcf7l2 Rpap3 Casp7 ENSRNOG00000065260
Bone: periosteal perimeter	13.02	23	2	4.5	0.95	6.11e-47	Rab11fip2 Cacul1 Dennd10 Grk5 Acsl5 Habp2 Nrap Nhlrc2 Afap1l2 Fhip2a Trub1 Atrnl1 AABR07007068.1 Nanos1 Dclre1a Zfp950 Ces2c Sfxn4 AABR07007032.1 Tcf7l2 Rpap3 Casp7 ENSRNOG00000065260
Bone: post-yield work	13.79	8	0	0	1	1.61e-29	Efemp2 Naaladl1 Sac3d1 Snx15 Scyl1 Snx32 Ehbp1l1 ENSRNOG00000062876
Bone: stiffness	15.98	2	0	0	0	1.00e+00	Ccdc57 Rpap3
Bone: trabecular thickness	14.8	5	0	0	1	6.71e-12	Rab11fip2 Cacul1 Grk5 Nanos1 Sfxn4
Cu content in liver	15.48	1	0	0	0	1.00e+00	Hoxb9

Associations by panel

Tissue	RNA modality	# hits	% hits/tests	Avg chisq
Adipose	alternative polyA	24	1.1	3.32
Adipose	alternative TSS	8	0.5	3.01
Adipose	gene expression	44	0.5	3.16
Adipose	isoform ratio	19	0.7	3.18
Adipose	intron excision ratio	14	0.5	2.8
Adipose	mRNA stability	18	0.5	3.15
BLA	alternative polyA	9	0.8	3.3
BLA	alternative TSS	6	0.7	3
BLA	gene expression	39	0.6	3.33
BLA	isoform ratio	19	1.1	3.44
BLA	intron excision ratio	15	0.5	3.21
BLA	mRNA stability	11	0.5	3.45
Brain	alternative polyA	17	0.8	3.24
Brain	alternative TSS	19	1.1	3.04
Brain	gene expression	51	0.6	3.26
Brain	isoform ratio	31	1	3.33
Brain	intron excision ratio	23	0.4	3.17
Brain	mRNA stability	22	0.5	3.15
Eye	alternative polyA	4	2.2	3.38
Eye	alternative TSS	2	0.8	2.8
Eye	gene expression	12	1.1	3.37
Eye	isoform ratio	2	0.6	3.56
Eye	intron excision ratio	5	0.8	3.07
Eye	mRNA stability	3	1.3	3.67
IL	alternative polyA	1	0.2	3.23
IL	alternative TSS	0	0	3.17
IL	gene expression	22	0.6	3.35
IL	isoform ratio	2	0.3	3.12
IL	intron excision ratio	2	0.2	3.1
IL	mRNA stability	8	0.7	3.3
LHb	alternative polyA	2	0.3	2.97
LHb	alternative TSS	0	0	2.62
LHb	gene expression	28	0.9	3.4
LHb	isoform ratio	1	0.1	2.87
LHb	intron excision ratio	0	0	2.91
LHb	mRNA stability	11	1.1	3.32
Liver	alternative polyA	15	1	3.36
Liver	alternative TSS	14	0.9	3.1
Liver	gene expression	51	0.7	3.21
Liver	isoform ratio	19	0.8	3.29
Liver	intron excision ratio	22	0.5	3
Liver	mRNA stability	21	0.9	3.29
NAcc	alternative polyA	11	0.8	3.51
NAcc	alternative TSS	11	1.2	3.21
NAcc	gene expression	42	0.7	3.4
NAcc	isoform ratio	18	1	3.56
NAcc	intron excision ratio	10	0.3	3.18
NAcc	mRNA stability	11	0.5	3.33
OFC	alternative polyA	0	0	3.39
OFC	alternative TSS	1	0.3	3.49
OFC	gene expression	24	0.6	3.43
OFC	isoform ratio	2	0.2	3.23
OFC	intron excision ratio	4	0.4	3.35
OFC	mRNA stability	7	0.6	3.43
PL	alternative polyA	12	0.8	3.41
PL	alternative TSS	10	0.9	3.1
PL	gene expression	55	0.7	3.34
PL	isoform ratio	14	0.6	3.4
PL	intron excision ratio	18	0.5	3.34
PL	mRNA stability	12	0.4	3.17