Gtf2a2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	RMTg	isoform ratio	NM_053345.2	0.09	0.09	9.6e-03	0.07	0.06	0.02	0.06	7.4e-03	8.6e-03	1.0e-01	1.2e-02
2	Adipose	alternative TSS	NM_001412186.1	0.03	0.03	2.5e-03	0.02	0.01	0	0.01	5.6e-03	1.7e-02	1.5e-01	1.1e-02
3	Adipose	alternative TSS	NM_001412186.1	0.03	0.03	2.5e-03	0.02	0.01	0.01	0.01	5.6e-03	1.7e-02	6.1e-02	1.0e-02
4	Adipose	alternative TSS	XM_039082206.1	0.03	0.03	2.2e-03	0.01	0.01	0	0.01	1.3e-02	1.6e-02	8.0e-02	1.6e-02
5	Adipose	alternative TSS	XM_039082206.1	0.03	0.03	2.2e-03	0.01	0.01	0.01	0.01	1.3e-02	1.6e-02	3.1e-02	1.5e-02
6	Adipose	isoform ratio	XM_039082206.1	0.02	0.02	7.4e-03	0.01	0.01	0	0.01	1.7e-02	5.5e-02	8.2e-02	3.0e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6
Bone: apparent density	0.6	1.1	1.1	-1.1	1.1	1.1	-1.1	-1.1	-0.9
Area under the delay curve	0.1	0.1	0.2	0.2	-0.3	-0.3	0.3	0.3	0.4
BMI with tail	5.9	19.3	20.3	4.4	-4.4	-4.4	4.4	4.4	4.5
BMI without tail	2.9	6.0	6.1	2.5	-2.4	-2.4	2.4	2.4	2.5
Body weight	4.4	18.4	19.4	4.3	-4.3	-4.3	4.3	4.3	4.4
Weight adjusted by age	5.4	6.1	7.2	2.4	-2.4	-2.4	2.4	2.4	2.7
Bone surface	0.0	0.0	0.1	0.1	-0.1	-0.1	0.1	0.1	0.3
Bone volume	0.0	0.0	0.0	-0.1	0.1	0.1	-0.1	-0.1	-0.0
Breakpoint value in progressive ratio session	0.4	0.4	0.4	0.6	-0.7	-0.7	0.7	0.7	0.6
Number of licking bursts	2.3	2.7	3.7	-1.6	1.6	1.6	-1.6	-1.6	-1.9
Context. condit. distance diff. score	1.1	1.3	1.3	-1.1	1.1	1.1	-1.1	-1.1	-1.1
Locomotion velocity, session 1	1.0	1.1	1.2	1.1	-1.1	-1.1	1.1	1.1	0.5
Locomotion distance, session 1	0.5	0.6	0.7	-0.8	0.8	0.8	-0.8	-0.8	-0.9
Locomotion velocity, session 2	0.0	0.0	0.0	0.1	-0.2	-0.2	0.2	0.2	0.1
Locomotion distance, session 2	0.0	0.0	0.0	0.2	-0.2	-0.2	0.2	0.2	0.1
Locomotion velocity, session 3	0.1	0.1	0.2	-0.2	0.2	0.2	-0.2	-0.2	-0.4
Locomotion distance, session 3	2.2	2.4	3.2	-1.5	1.5	1.5	-1.5	-1.5	-1.8
Stereotopy head waving bouts, day 3	0.9	1.0	1.2	1.0	-1.0	-1.0	1.0	1.0	1.1
Stereotopy head waving duration, day 3	1.0	1.2	1.3	1.1	-1.1	-1.1	1.1	1.1	1.1
Locomotion velocity, session 7	1.6	1.7	2.7	-1.2	1.3	1.3	-1.3	-1.3	-1.6
Locomotion distance, session 7	1.2	1.6	2.8	-1.1	1.2	1.2	-1.2	-1.2	-1.7
Stereotopy head waving bouts, day 7	1.7	1.9	2.7	1.3	-1.3	-1.3	1.3	1.3	1.6
Stereotopy head waving duration, day 7	1.6	1.9	2.7	1.3	-1.4	-1.4	1.4	1.4	1.7
Locomotion velocity, session 8	0.1	0.2	0.3	0.5	-0.4	-0.4	0.4	0.4	-0.2
Locomotion distance, session 8	0.9	1.4	1.6	-1.1	1.2	1.2	-1.2	-1.2	-1.2
Degree of sensitization distance	0.0	0.0	0.0	-0.1	0.2	0.2	-0.2	-0.2	-0.1
Degree of sensitization stereotypy	1.0	1.1	1.6	0.9	-1.0	-1.0	1.0	1.0	1.3
Conditioned locomotion	0.0	0.1	0.1	-0.2	0.2	0.2	-0.2	-0.2	-0.4
Cocaine response after cond. corrected	3.8	4.3	4.5	2.1	-2.1	-2.1	2.1	2.1	1.8
Cocaine response after cond. not corrected	2.0	2.2	2.4	1.5	-1.5	-1.5	1.5	1.5	1.2
Cocaine response before conditioning	1.5	1.8	1.9	-1.4	1.4	1.4	-1.4	-1.4	-1.1
Saline control response	0.1	0.1	0.1	-0.3	0.3	0.3	-0.3	-0.3	0.1
Bone: connectivity density	1.3	2.1	2.3	-1.5	1.5	1.5	-1.5	-1.5	-1.3
Bone: cortical apparent density	0.5	0.7	0.7	-0.8	0.8	0.8	-0.8	-0.8	-0.8
Bone: cortical area	0.0	0.1	0.1	-0.2	0.2	0.2	-0.2	-0.2	-0.3
Bone: cortical porosity	0.7	0.8	0.8	-0.9	0.9	0.9	-0.9	-0.9	-0.6
Bone: cortical porosity	1.6	1.7	1.8	-1.3	1.3	1.3	-1.3	-1.3	-1.2
Bone: cortical thickness	1.4	2.3	2.7	-1.5	1.5	1.5	-1.5	-1.5	-1.6
Bone: cortical thickness	1.1	1.3	1.8	-1.1	1.1	1.1	-1.1	-1.1	-1.3
Bone: cortical tissue density	0.5	0.6	0.7	-0.8	0.8	0.8	-0.8	-0.8	-0.8
Condit. Reinf. active minus inactive responses	0.1	0.1	0.1	-0.4	0.4	0.4	-0.4	-0.4	0.0
Condit. Reinf. active-inactive response ratio	0.8	0.9	1.0	-1.0	1.0	1.0	-1.0	-1.0	-0.7
Condit. Reinf. active responses	0.2	0.2	0.6	0.4	-0.4	-0.4	0.4	0.4	0.7
Condit. Reinf. inactive responses	1.1	1.3	1.4	1.2	-1.1	-1.1	1.1	1.1	1.1
Incentive salience index mean	0.1	0.1	0.2	-0.4	0.4	0.4	-0.4	-0.4	-0.1
Condit. Reinf. lever presses	0.2	0.2	0.2	-0.5	0.5	0.5	-0.5	-0.5	-0.4
Condit. Reinf. active minus inactive responses	2.1	2.6	3.0	1.6	-1.6	-1.6	1.6	1.6	1.7
Condit. Reinf. active-inactive response ratio	0.8	0.8	1.1	0.9	-0.9	-0.9	0.9	0.9	1.0
Condit. Reinf. active responses	0.8	1.2	1.5	1.1	-1.0	-1.0	1.0	1.0	1.2
Condit. Reinf. inactive responses	0.1	0.1	0.2	-0.4	0.4	0.4	-0.4	-0.4	-0.2
Condit. Reinf. lever presses	0.9	1.3	1.4	-1.2	1.2	1.2	-1.2	-1.2	-0.8
Condit. Reinf. lever reinforcers received	0.4	0.5	0.8	0.7	-0.7	-0.7	0.7	0.7	0.9
Conditioned reinforcement - actives	0.4	0.4	0.5	0.7	-0.7	-0.7	0.7	0.7	0.5
Conditioned reinforcement - inactives	0.0	0.0	0.0	0.2	-0.2	-0.2	0.2	0.2	0.0
Conditioned locomotion	0.2	0.2	0.3	-0.4	0.4	0.4	-0.4	-0.4	-0.6
Patch foraging indifference point 0 sec	0.1	0.1	0.3	0.3	-0.3	-0.3	0.3	0.3	0.6
Patch foraging indifference point AUC	0.0	0.0	0.1	-0.0	-0.0	-0.0	0.0	0.0	-0.3
Delay disc. indifference point, 0s delay	0.1	0.1	0.1	-0.4	0.3	0.3	-0.3	-0.3	-0.3
Delay disc. indifference point, 16s delay	0.0	0.0	0.0	0.0	-0.2	-0.2	0.2	0.2	0.1
Delay disc. indifference point, 2s delay	0.0	0.0	0.0	0.0	0.0	0.0	-0.0	-0.0	0.2
Delay disc. indifference point, 24s delay	0.1	0.1	0.1	-0.4	0.3	0.3	-0.3	-0.3	-0.3
Delay disc. indifference point, 4s delay	0.0	0.0	0.1	-0.1	-0.0	-0.0	0.0	0.0	0.2
Delay disc. indifference point, 8s delay	0.2	0.2	0.2	0.4	-0.4	-0.4	0.4	0.4	0.5
Indifference point function ln k	0.4	0.6	0.7	0.7	-0.7	-0.7	0.7	0.7	0.8
Indifference point function log k	0.4	0.6	0.7	0.7	-0.7	-0.7	0.7	0.7	0.8
Patch foraging total patch changes 0 sec	0.1	0.2	0.5	0.4	-0.4	-0.4	0.4	0.4	0.7
Patch foraging total patch changes 12 sec	0.1	0.1	0.1	-0.3	0.3	0.3	-0.3	-0.3	0.1
Patch foraging total patch changes 18 sec	0.1	0.1	0.1	0.4	-0.4	-0.4	0.4	0.4	0.3
Patch foraging total patch changes 24 sec	0.0	0.0	0.0	-0.1	0.1	0.1	-0.1	-0.1	0.1
Patch foraging total patch changes 6 sec	0.3	0.5	0.7	0.6	-0.7	-0.7	0.7	0.7	0.8
Patch foraging time to switch 0 sec	0.8	1.2	1.3	-1.0	1.1	1.1	-1.1	-1.1	-1.2
Patch foraging water rate 0 sec	2.0	3.1	3.8	1.7	-1.7	-1.7	1.7	1.7	2.0
Patch foraging water rate 12 sec	2.8	4.2	4.3	2.0	-2.1	-2.1	2.1	2.1	2.0
Patch foraging water rate 18 sec	0.2	0.2	0.6	0.4	-0.3	-0.3	0.3	0.3	0.8
Patch foraging water rate 24 sec	0.1	0.2	0.3	0.6	-0.4	-0.4	0.4	0.4	0.2
Patch foraging water rate 6 sec	0.8	1.2	1.8	1.0	-1.1	-1.1	1.1	1.1	1.3
Seeking ratio, delayed vs. immediate footshock	0.8	0.9	1.1	1.1	-1.0	-1.0	1.0	1.0	0.9
Distance traveled before self-admin	0.5	0.5	0.5	0.6	-0.7	-0.7	0.7	0.7	0.6
Distance traveled after self-admin	1.6	1.8	2.2	1.3	-1.3	-1.3	1.3	1.3	1.5
Extensor digitorum longus weight	8.0	31.6	32.6	5.7	-5.7	-5.7	5.7	5.7	5.4
Bone: elastic displacement	0.3	0.4	0.5	0.6	-0.6	-0.6	0.6	0.6	0.7
Bone: elastic work	0.0	0.0	0.0	0.1	-0.1	-0.1	0.1	0.1	-0.0
Bone: endosteal estimation	2.1	4.5	4.6	2.1	-2.1	-2.1	2.1	2.1	2.1
Bone: endosteal perimeter	3.2	6.7	6.9	2.6	-2.6	-2.6	2.6	2.6	2.4
Epididymis fat weight	0.0	0.0	0.0	0.1	-0.1	-0.1	0.1	0.1	0.2
Delta time in closed arm before/after self-admin	0.1	0.1	0.1	-0.4	0.3	0.3	-0.3	-0.3	-0.2
Delta time in open arm before/after self-admin	0.9	0.9	1.1	-0.9	0.9	0.9	-0.9	-0.9	-1.1
Diff in mean of infusions in LGA sessions	1.2	1.3	1.7	1.1	-1.1	-1.1	1.1	1.1	1.3
Delay discount exponential model param	0.2	0.2	0.3	-0.4	0.4	0.4	-0.4	-0.4	-0.6
Extinction: sum of active levers before priming	0.0	0.0	0.0	-0.2	0.2	0.2	-0.2	-0.2	0.1
Active lever presses in extinction session 6	0.0	0.0	0.1	0.2	-0.2	-0.2	0.2	0.2	0.1
Bone: final force	0.4	0.6	0.6	0.8	-0.8	-0.8	0.8	0.8	0.5
Bone: final moment	0.1	0.1	0.1	0.4	-0.4	-0.4	0.4	0.4	0.2
Food consumed during 24 hour testing period	0.8	0.9	1.6	0.9	-0.9	-0.9	0.9	0.9	1.3
Glucose	0.3	0.4	0.5	0.7	-0.7	-0.7	0.7	0.7	0.6
Heart weight	0.4	0.6	0.7	0.8	-0.8	-0.8	0.8	0.8	0.6
Delay discount hyperbolic model param	0.1	0.1	0.2	-0.2	0.3	0.3	-0.3	-0.3	-0.4
Intermittent access intake day 1-15 change	0.9	0.9	0.9	-1.0	1.0	1.0	-1.0	-1.0	-0.9
Intermittent access intake escalation	1.2	1.1	1.2	-1.1	1.1	1.1	-1.1	-1.1	-1.0
Intermittent access intake escalation 2	0.0	0.0	0.0	0.1	-0.1	-0.1	0.1	0.1	0.1
Intermitt. access day 1 inactive lever presses	1.6	1.8	2.0	-1.3	1.3	1.3	-1.3	-1.3	-1.4
Intermitt. access day 15 inactive lever presses	0.0	0.0	0.0	-0.0	0.0	0.0	-0.0	-0.0	-0.2
Intermitt. access escalation Index	1.6	1.4	1.5	1.2	-1.2	-1.2	1.2	1.2	1.2
Intermittent access day 1 total infusions	0.2	0.2	0.3	-0.4	0.4	0.4	-0.4	-0.4	-0.6
Intermittent access day 15 total infusions	1.0	1.1	1.1	-1.0	1.0	1.0	-1.0	-1.0	-1.0
Intermittent access terminal intake (last 3 days)	0.2	0.2	0.2	-0.5	0.5	0.5	-0.5	-0.5	-0.5
Intermittent access total infusions	0.1	0.1	0.2	-0.4	0.4	0.4	-0.4	-0.4	-0.4
Intermittent access day 1 locomotion	1.8	1.9	1.9	-1.4	1.4	1.4	-1.4	-1.4	-1.3
Intermittent access day 15 total locomotion	1.7	1.8	1.8	-1.3	1.4	1.4	-1.4	-1.4	-1.3
Intermittent access total locomotion	0.0	0.0	0.0	-0.1	0.1	0.1	-0.1	-0.1	0.0
Intermittent access standard deviation	0.9	1.0	1.1	-1.0	1.0	1.0	-1.0	-1.0	-0.9
Left kidney weight	2.5	6.9	7.2	2.7	-2.6	-2.6	2.6	2.6	2.6
Right kidney weight	2.5	7.1	7.7	2.7	-2.6	-2.6	2.6	2.6	2.8
Cocaine induced anxiety	0.0	0.1	0.1	-0.2	0.2	0.2	-0.2	-0.2	-0.2
Post-drug Anxiety	1.9	2.1	2.4	-1.4	1.4	1.4	-1.4	-1.4	-1.5
Baseline Anxiety	0.4	0.5	0.6	-0.7	0.7	0.7	-0.7	-0.7	-0.8
Tail length	0.0	0.1	0.3	0.3	-0.3	-0.3	0.3	0.3	0.5
Length with tail	0.7	2.6	2.7	1.6	-1.6	-1.6	1.6	1.6	1.6
Length without tail	2.0	4.4	4.8	2.1	-2.1	-2.1	2.1	2.1	2.2
Times rat made contact with spout	0.2	0.3	0.3	-0.5	0.5	0.5	-0.5	-0.5	-0.4
Lifetime Intake	0.2	0.3	0.4	-0.5	0.5	0.5	-0.5	-0.5	-0.6
Liver weight, left	0.4	0.6	0.7	0.7	-0.7	-0.7	0.7	0.7	0.8
Liver weight, right	1.2	2.0	2.1	1.4	-1.4	-1.4	1.4	1.4	1.3
Locomotor activity	6.8	10.7	11.0	3.2	-3.3	-3.3	3.3	3.3	3.3
Locomotor testing distance	3.5	5.8	6.4	2.4	-2.4	-2.4	2.4	2.4	2.5
Locomotor testing rearing	1.9	3.0	3.8	1.7	-1.7	-1.7	1.7	1.7	1.9
Locomotion in novel chamber	0.9	1.1	1.3	-1.2	1.1	1.1	-1.1	-1.1	-0.8
Locomotion in novel chamber post-restriction	0.2	0.3	0.3	-0.4	0.6	0.6	-0.6	-0.6	-0.4
Fecal boli incidents, locomotor time 1	0.0	0.0	0.0	-0.1	0.1	0.1	-0.1	-0.1	0.2
Change in fecal boli incidents, locomotor task	0.0	0.0	0.0	0.2	-0.1	-0.1	0.1	0.1	-0.1
Time >=10cm from walls, locomotor time 1	0.3	0.3	0.3	0.5	-0.5	-0.5	0.5	0.5	0.5
Bouts of movement, locomotor time 1	0.0	0.0	0.0	0.1	0.0	0.0	-0.0	-0.0	0.2
Total resting periods, locomotor time 1	0.0	0.0	0.0	0.0	0.0	0.0	-0.0	-0.0	0.2
Rest time, locomotor task time 1	0.0	0.0	0.0	-0.1	0.1	0.1	-0.1	-0.1	-0.2
Distance moved, locomotor task time 1	0.1	0.1	0.1	-0.3	0.3	0.3	-0.3	-0.3	-0.3
Vertical activity count, locomotor time 1	0.0	0.0	0.0	-0.1	0.2	0.2	-0.2	-0.2	-0.2
Time >=10cm from walls, locomotor time 2	0.0	0.0	0.0	-0.2	0.2	0.2	-0.2	-0.2	-0.2
Bouts of movement, locomotor time 2	2.5	2.6	2.8	1.6	-1.7	-1.7	1.7	1.7	1.4
Total resting periods, locomotor time 2	2.8	3.0	3.2	1.7	-1.8	-1.8	1.8	1.8	1.5
Rest time, locomotor task time 2	0.2	0.2	0.3	-0.5	0.4	0.4	-0.4	-0.4	-0.5
Distance moved, locomotor task time 2	0.1	0.1	0.2	-0.2	0.3	0.3	-0.3	-0.3	-0.4
Vertical activity count, locomotor time 2	0.2	0.2	0.3	-0.4	0.4	0.4	-0.4	-0.4	-0.5
Light reinforcement 1	2.3	4.1	4.3	1.9	-2.0	-2.0	2.0	2.0	2.1
Light reinforcement 2	0.4	0.5	0.5	-0.7	0.7	0.7	-0.7	-0.7	-0.6
Bone: marrow area	2.1	4.6	4.7	2.2	-2.2	-2.2	2.2	2.2	2.1
Bone: maximum diameter	1.9	3.5	3.7	1.9	-1.9	-1.9	1.9	1.9	1.6
Bone: maximum force	0.5	0.8	0.9	0.9	-0.9	-0.9	0.9	0.9	0.7
Bone: maximum moment	0.2	0.3	0.3	0.5	-0.5	-0.5	0.5	0.5	0.4
Mean time between licks in bursts	0.2	0.3	0.5	-0.5	0.5	0.5	-0.5	-0.5	-0.7
Mean num. licks in bursts	1.2	1.4	2.2	1.1	-1.1	-1.1	1.1	1.1	1.5
Cd content in liver	0.1	0.1	0.1	-0.2	0.2	0.2	-0.2	-0.2	-0.3
Co content in liver	0.0	0.0	0.1	-0.2	0.2	0.2	-0.2	-0.2	-0.3
Cu content in liver	0.3	0.3	0.4	0.6	-0.6	-0.6	0.6	0.6	0.2
Fe content in liver	0.5	0.6	0.7	-0.8	0.8	0.8	-0.8	-0.8	-0.7
K content in liver	1.7	1.7	2.1	1.3	-1.3	-1.3	1.3	1.3	1.5
Mg content in liver	3.6	3.7	3.8	1.9	-1.9	-1.9	1.9	1.9	1.9
Mn content in liver	0.0	0.0	0.0	0.1	-0.1	-0.1	0.1	0.1	0.1
Na content in liver	1.9	2.0	2.2	1.4	-1.4	-1.4	1.4	1.4	1.5
Rb content in liver	2.1	2.6	2.8	1.7	-1.7	-1.7	1.7	1.7	1.4
Se content in liver	0.5	0.6	0.6	-0.8	0.8	0.8	-0.8	-0.8	-0.5
Sr content in liver	0.0	0.0	0.0	-0.2	0.2	0.2	-0.2	-0.2	-0.1
Zn content in liver	0.4	0.5	0.5	-0.7	0.7	0.7	-0.7	-0.7	-0.7
Bone: minimum diameter	0.0	0.0	0.0	-0.2	0.2	0.2	-0.2	-0.2	-0.0
Time in familiar zone, hab. session 1	0.1	0.1	0.1	-0.2	0.3	0.3	-0.3	-0.3	-0.2
Time in novel zone, hab. session 1	0.0	0.0	0.0	0.0	-0.0	-0.0	0.0	0.0	-0.1
Total zone transitions, hab. session 1	0.8	1.1	1.5	-1.0	1.0	1.0	-1.0	-1.0	-1.2
Total locomotion distance, hab. session 1	0.1	0.2	0.2	-0.4	0.4	0.4	-0.4	-0.4	-0.5
Locomotion velocity, hab. session 1	0.0	0.0	0.0	-0.2	0.2	0.2	-0.2	-0.2	-0.1
Time in familiar zone, hab. session 2	0.0	0.0	0.1	-0.1	0.0	0.0	-0.0	-0.0	-0.3
Time in novel zone, hab. session 2	0.1	0.1	0.1	-0.3	0.3	0.3	-0.3	-0.3	0.0
Total zone transitions, hab. session 2	0.1	0.1	0.1	0.3	-0.3	-0.3	0.3	0.3	-0.0
Total locomotion distance, hab. session 2	0.4	0.6	0.6	0.8	-0.8	-0.8	0.8	0.8	0.7
Locomotion velocity, hab. session 2	0.2	0.2	0.2	0.5	-0.5	-0.5	0.5	0.5	0.4
Novel to familiar place preference ratio	1.3	1.4	1.9	1.1	-1.1	-1.1	1.1	1.1	1.4
Novelty place preference	1.4	1.4	1.9	1.1	-1.2	-1.2	1.2	1.2	1.4
Time in novel zone, NPP test	1.6	1.7	2.2	1.3	-1.3	-1.3	1.3	1.3	1.5
Total zone transitions, NPP test	0.0	0.0	0.1	0.2	-0.2	-0.2	0.2	0.2	0.3
Total locomotion distance, NPP test	0.3	0.4	0.7	0.6	-0.6	-0.6	0.6	0.6	0.9
Locomotion velocity, NPP test	0.1	0.1	0.3	0.3	-0.3	-0.3	0.3	0.3	0.5
Intraocular pressure	0.2	0.2	0.3	0.5	-0.5	-0.5	0.5	0.5	0.1
Delta distance traveled before/after self-admin	0.5	0.5	0.6	0.7	-0.7	-0.7	0.7	0.7	0.8
Delta ambulatory time before/after self-admin	0.1	0.1	0.2	0.3	-0.2	-0.2	0.2	0.2	0.4
Parametrial fat weight	0.0	0.0	0.1	0.2	-0.1	-0.1	0.1	0.1	-0.3
Pavlov. Cond. lever latency	0.0	0.0	0.1	0.2	-0.1	-0.1	0.1	0.1	-0.3
Pavlov. Cond. magazine entry latency	1.1	1.4	1.4	-1.2	1.2	1.2	-1.2	-1.2	-1.1
Pavlov. Cond. change in total contacts	0.1	0.1	0.2	-0.5	0.4	0.4	-0.4	-0.4	0.1
Pavlov. Cond. index score	1.0	1.3	1.5	-1.2	1.2	1.2	-1.2	-1.2	-0.9
Pavlov. Cond. latency score	0.6	0.7	0.9	-0.9	0.9	0.9	-0.9	-0.9	-0.6
Pavlov. Cond. lever contacts	0.2	0.2	0.3	-0.5	0.5	0.5	-0.5	-0.5	-0.3
Pavlov. Cond. magazine entry number	1.5	1.9	2.0	1.4	-1.4	-1.4	1.4	1.4	1.2
Pavlov. Cond. intertrial magazine entries	0.1	0.1	0.1	0.3	-0.4	-0.4	0.4	0.4	0.2
Pavlov. Cond. lever-magazine prob. diff.	0.8	1.0	1.1	-1.1	1.0	1.0	-1.0	-1.0	-0.8
Pavlov. Cond. response bias	0.8	1.0	1.1	-1.1	1.0	1.0	-1.0	-1.0	-0.8
Pavlov. Cond. lever latency	0.9	1.2	1.3	1.1	-1.1	-1.1	1.1	1.1	1.1
Pavlov. Cond. magazine entry latency	3.9	4.6	4.7	-2.2	2.2	2.2	-2.2	-2.2	-2.0
Pavlov. Cond. change in total contacts	0.4	0.6	0.6	-0.8	0.8	0.8	-0.8	-0.8	-0.7
Pavlov. Cond. index score	1.3	1.6	1.7	-1.3	1.3	1.3	-1.3	-1.3	-1.2
Pavlov. Cond. latency score	0.9	1.1	1.1	-1.0	1.0	1.0	-1.0	-1.0	-1.0
Pavlov. Cond. lever contacts	0.3	0.5	0.5	-0.7	0.7	0.7	-0.7	-0.7	-0.6
Pavlov. Cond. magazine entry number	3.3	4.1	4.2	2.0	-2.0	-2.0	2.0	2.0	2.0
Pavlov. Cond. intertrial magazine entries	0.6	0.8	0.8	0.9	-0.9	-0.9	0.9	0.9	0.8
Pavlov. Cond. lever-magazine prob. diff.	1.4	1.8	1.8	-1.3	1.3	1.3	-1.3	-1.3	-1.3
Pavlov. Cond. response bias	1.3	1.7	1.8	-1.3	1.3	1.3	-1.3	-1.3	-1.2
Time in closed arm before self-admin	0.0	0.0	0.0	0.1	-0.1	-0.1	0.1	0.1	-0.1
Time in closed arm after self-admin	0.0	0.0	0.0	-0.0	-0.1	-0.1	0.1	0.1	-0.0
Time in open arm before self-admin	0.8	0.8	1.3	0.9	-0.8	-0.8	0.8	0.8	1.2
Time in open arm after self-admin	0.0	0.0	0.0	-0.2	0.2	0.2	-0.2	-0.2	0.0
Bone: periosteal estimation	1.1	2.2	2.3	1.5	-1.5	-1.5	1.5	1.5	1.4
Bone: periosteal perimeter	1.7	2.8	2.9	1.7	-1.7	-1.7	1.7	1.7	1.6
Bone: post-yield work	0.1	0.1	0.2	0.4	-0.4	-0.4	0.4	0.4	0.4
Progressive ratio test 1 active lever presses	0.3	0.3	0.3	0.6	-0.6	-0.6	0.6	0.6	0.4
Progressive ratio test 1 breakpoint	0.0	0.0	0.0	0.2	-0.2	-0.2	0.2	0.2	-0.0
Progressive ratio test 1 inactive lever presses	0.9	1.0	1.7	-0.9	0.9	0.9	-0.9	-0.9	-1.3
Progressive ratio test 2 active lever presses	0.3	0.3	0.3	0.6	-0.6	-0.6	0.6	0.6	0.6
Progressive ratio test 2 breakpoint	0.5	0.5	0.5	0.7	-0.7	-0.7	0.7	0.7	0.7
Progressive ratio test 2 inactive lever presses	0.4	0.4	0.5	-0.7	0.7	0.7	-0.7	-0.7	-0.6
Incentive Sensitization - Responses	0.4	0.4	0.6	0.6	-0.6	-0.6	0.6	0.6	0.7
Incentive Sensitization - Breakpoint	0.2	0.2	0.3	0.4	-0.4	-0.4	0.4	0.4	0.6
Sum of active levers in priming session hrs 5-6	0.0	0.0	0.0	0.1	-0.1	-0.1	0.1	0.1	0.2
Progressive ratio	0.4	0.4	0.6	-0.7	0.6	0.6	-0.6	-0.6	-0.8
Food seeking constrained by brief footshock	0.6	0.7	0.8	0.9	-0.9	-0.9	0.9	0.9	0.6
Seeking ratio, punishment vs. effort	2.8	3.4	3.5	1.8	-1.8	-1.8	1.8	1.8	1.9
Retroperitoneal fat weight	0.0	0.0	0.0	0.2	-0.2	-0.2	0.2	0.2	-0.0
Reaction time number correct	2.0	2.9	3.1	1.8	-1.7	-1.7	1.7	1.7	1.5
Reaction time mean minus median	0.3	0.4	0.5	-0.6	0.7	0.7	-0.7	-0.7	-0.4
Reaction time mean minus median AUC	1.2	1.5	1.6	-1.2	1.3	1.3	-1.3	-1.3	-1.1
Reaction time num false alarms	0.7	1.0	1.6	-0.9	1.0	1.0	-1.0	-1.0	-1.3
Reaction time num false alarms AUC	0.3	0.4	0.7	-0.5	0.6	0.6	-0.6	-0.6	-0.8
Reaction time trials correct on left	2.0	2.9	3.1	1.8	-1.7	-1.7	1.7	1.7	1.5
Reaction time trials on left	2.1	3.0	3.3	1.8	-1.8	-1.8	1.8	1.8	1.5
Reaction time mean	3.3	4.6	4.6	-2.1	2.1	2.1	-2.1	-2.1	-2.1
Reaction time mean AUC	2.4	3.3	3.4	-1.7	1.8	1.8	-1.8	-1.8	-1.8
Median of all reaction times	4.4	6.0	6.7	-2.4	2.4	2.4	-2.4	-2.4	-2.6
Reaction time omissions	0.3	0.5	0.5	0.7	-0.7	-0.7	0.7	0.7	0.6
Reaction time false alarm rate	1.8	2.5	2.9	-1.5	1.6	1.6	-1.6	-1.6	-1.7
Reaction time premature initiation rate	1.9	2.6	2.6	1.6	-1.6	-1.6	1.6	1.6	1.5
Reaction time premature initiations	3.3	4.7	4.9	2.2	-2.2	-2.2	2.2	2.2	2.0
Std. dev. reaction times	1.4	2.0	2.2	-1.4	1.5	1.5	-1.5	-1.5	-1.2
Reaction time trials completed	2.1	3.0	3.3	1.8	-1.8	-1.8	1.8	1.8	1.5
Reaction time trials AUC	1.8	2.6	2.8	1.7	-1.6	-1.6	1.6	1.6	1.4
Run reversals in cocaine runway, females	0.0	0.0	0.0	0.1	-0.1	-0.1	0.1	0.1	0.0
Run reversals in cocaine runway, males	0.0	0.0	0.0	0.1	-0.1	-0.1	0.1	0.1	-0.1
Latency to leave start box in cocaine runway	3.1	3.4	3.7	1.7	-1.8	-1.8	1.8	1.8	1.9
Latency to leave start box in cocaine runway, F	0.6	0.7	1.0	0.7	-0.8	-0.8	0.8	0.8	1.0
Latency to leave start box in cocaine runway, M	4.5	4.3	4.4	2.1	-2.1	-2.1	2.1	2.1	2.0
Std. dev. time between licks in bursts	0.2	0.3	0.3	0.5	-0.5	-0.5	0.5	0.5	0.5
Total sessions with >9 infusions	0.0	0.0	0.1	-0.1	0.1	0.1	-0.1	-0.1	-0.3
Short access day 1 total inactive lever presses	0.1	0.1	0.3	-0.3	0.3	0.3	-0.3	-0.3	-0.6
Short access day 10 total inactive lever presses	0.5	0.5	0.8	-0.7	0.7	0.7	-0.7	-0.7	-0.9
Short access day 1 total infusions	0.2	0.2	0.3	-0.4	0.4	0.4	-0.4	-0.4	-0.6
Short access day 10 total infusions	0.3	0.3	0.4	-0.5	0.5	0.5	-0.5	-0.5	-0.6
Short access total infusions	0.6	0.7	1.0	-0.8	0.8	0.8	-0.8	-0.8	-1.0
Short access day 1 locomotion	0.0	0.0	0.1	-0.0	-0.0	-0.0	0.0	0.0	-0.3
Short access day 10 total locomotion	0.0	0.0	0.0	0.0	-0.0	-0.0	0.0	0.0	0.0
Short access total locomotion	0.8	0.8	1.1	-0.9	0.9	0.9	-0.9	-0.9	-1.0
One hour access (0.3 mA shock)	0.2	0.2	0.3	0.5	-0.5	-0.5	0.5	0.5	0.4
Compulsive drug intake	0.3	0.3	0.3	0.6	-0.6	-0.6	0.6	0.6	0.3
One hour access (shock baseline)	0.1	0.1	0.2	-0.4	0.4	0.4	-0.4	-0.4	-0.4
Social response proportion	0.2	0.2	0.3	-0.5	0.5	0.5	-0.5	-0.5	-0.1
Social responses	0.0	0.0	0.1	-0.1	0.1	0.1	-0.1	-0.1	0.3
Social time	0.0	0.0	0.2	-0.1	0.0	0.0	-0.0	-0.0	0.4
Soleus weight	16.3	47.7	48.2	6.9	-6.9	-6.9	6.9	6.9	6.8
Bone: stiffness	1.2	1.8	2.0	1.3	-1.4	-1.4	1.4	1.4	1.4
Tibialis anterior weight	12.4	42.3	43.0	6.6	-6.5	-6.5	6.5	6.5	6.4
Time to tail flick, vehicle, before self-admin	0.3	0.3	0.3	-0.5	0.6	0.6	-0.6	-0.6	-0.5
Time to tail flick, vehicle, after self-admin	0.0	0.0	0.0	-0.1	0.0	0.0	-0.0	-0.0	-0.1
Time to tail flick, test, before self-admin	1.1	1.0	1.1	-1.0	1.1	1.1	-1.1	-1.1	-0.8
Time to tail flick, test, after self-admin	0.5	0.5	0.6	-0.7	0.7	0.7	-0.7	-0.7	-0.8
Delta time to tail flick, vehicle, before/after SA	0.0	0.0	0.0	-0.1	0.0	0.0	-0.0	-0.0	-0.1
Delta time to tail flick, test, before/after SA	0.2	0.2	0.2	0.4	-0.4	-0.4	0.4	0.4	0.3
Tibia length	0.1	0.3	0.4	-0.6	0.5	0.5	-0.5	-0.5	-0.3
Ambulatory time before self-admin	0.0	0.0	0.0	0.1	-0.2	-0.2	0.2	0.2	-0.0
Ambulatory time after self-admin	0.6	0.6	0.6	0.8	-0.8	-0.8	0.8	0.8	0.8
Bone: tissue strength	1.5	1.4	1.5	-1.2	1.2	1.2	-1.2	-1.2	-1.1
Total heroin consumption	2.9	3.4	3.5	1.7	-1.9	-1.9	1.9	1.9	1.9
Bone: trabecular number	1.9	2.9	3.0	-1.7	1.7	1.7	-1.7	-1.7	-1.7
Bone: trabecular spacing	0.0	0.0	0.0	0.2	-0.2	-0.2	0.2	0.2	0.1
Bone: trabecular thickness	0.3	0.3	0.4	-0.6	0.6	0.6	-0.6	-0.6	-0.6
Bone: trabecular tissue density	5.5	7.8	8.1	2.8	-2.8	-2.8	2.8	2.8	2.6
Water consumed over 24 hours	0.5	0.6	0.7	-0.9	0.8	0.8	-0.8	-0.8	-0.6
Number of responses in last shaping day	0.0	0.0	0.0	-0.2	0.2	0.2	-0.2	-0.2	-0.0