Hub : Genes

Gtf2a2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	IL	gene expression	Gtf2a2	0.14	0.13	5.1e-03	0.06	0.07	0.07	0.07	1.3e-02	1.1e-02	9.6e-03	1.0e-02
2	Adipose	alternative TSS	XM_063266220.1	0.04	0.03	4.1e-04	0.02	0.02	0	0.02	4.8e-03	1.9e-03	1.5e-01	6.6e-03
3	Adipose	alternative TSS	XM_063266220.1	0.03	0.03	1.3e-03	0.01	0.02	0.01	0.01	8.0e-03	4.0e-03	7.5e-03	1.2e-02
4	RMTg	alternative polyA	XM_063266222.1	0.18	0.15	4.9e-04	0.1	0.09	0.1	0.09	1.1e-03	2.3e-03	1.6e-03	1.8e-03
5	NAcc	isoform ratio	NR_178067.1	0.02	0.02	1.8e-03	0.01	0.01	0.01	0.01	2.3e-03	4.7e-03	8.5e-03	2.5e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bone: apparent density	0.5	1.0	1.2	-1.1	0.9	0.9	1.1	-0.8
Area under the delay curve	0.0	0.1	0.1	0.2	-0.3	-0.3	-0.2	-0.2
BMI with tail	7.1	24.8	26.2	5.1	-5.0	-5.0	-5.1	4.8
BMI without tail	1.7	9.1	9.7	3.0	-3.0	-3.0	-3.0	3.1
Body weight	4.9	21.2	21.8	4.7	-4.6	-4.6	-4.6	4.5
Weight adjusted by age	2.2	6.3	6.9	2.5	-2.6	-2.6	-2.4	2.4
Bone surface	0.0	0.0	0.1	0.1	-0.3	-0.3	0.0	0.3
Bone volume	0.0	0.0	0.0	-0.1	0.1	0.1	0.2	0.1
Breakpoint value in progressive ratio session	0.7	1.2	1.7	1.0	-1.1	-1.1	-1.1	1.3
Number of licking bursts	0.9	2.6	3.3	-1.6	1.8	1.8	1.5	-1.4
Context. condit. distance diff. score	0.9	1.1	1.2	-1.0	1.1	1.1	0.9	-1.1
Locomotion velocity, session 1	0.6	0.7	1.5	0.7	-0.6	-0.6	-0.7	1.2
Locomotion distance, session 1	0.5	0.6	0.7	-0.8	0.9	0.9	0.7	-0.6
Locomotion velocity, session 2	0.1	0.1	0.2	0.3	-0.1	-0.1	-0.2	0.4
Locomotion distance, session 2	0.0	0.0	0.1	0.1	-0.0	-0.0	-0.3	0.3
Locomotion velocity, session 3	0.1	0.1	0.2	-0.4	0.4	0.4	0.4	-0.3
Locomotion distance, session 3	2.4	2.7	3.0	-1.6	1.7	1.7	1.6	-1.5
Stereotopy head waving bouts, day 3	0.9	1.1	1.3	1.0	-1.1	-1.1	-0.9	0.9
Stereotopy head waving duration, day 3	1.1	1.4	1.5	1.2	-1.2	-1.2	-1.1	1.0
Locomotion velocity, session 7	2.1	2.3	2.6	-1.6	1.6	1.6	1.4	-1.2
Locomotion distance, session 7	1.8	2.3	2.8	-1.6	1.7	1.7	1.2	-1.3
Stereotopy head waving bouts, day 7	1.8	2.1	2.7	1.5	-1.6	-1.6	-1.3	1.2
Stereotopy head waving duration, day 7	1.6	1.9	2.6	1.4	-1.6	-1.6	-1.2	1.1
Locomotion velocity, session 8	0.1	0.1	0.3	0.2	0.1	0.1	-0.3	0.6
Locomotion distance, session 8	0.8	1.2	1.6	-1.1	1.2	1.2	0.9	-1.0
Degree of sensitization distance	0.1	0.1	0.1	-0.3	0.2	0.2	0.1	-0.3
Degree of sensitization stereotypy	1.0	1.1	1.5	1.1	-1.2	-1.2	-0.9	0.8
Conditioned locomotion	0.1	0.1	0.2	-0.2	0.4	0.4	0.3	-0.2
Cocaine response after cond. corrected	2.7	4.1	4.6	2.1	-1.9	-1.9	-2.1	2.1
Cocaine response after cond. not corrected	1.6	2.3	2.6	1.5	-1.4	-1.4	-1.6	1.6
Cocaine response before conditioning	1.1	1.4	1.8	-1.3	1.0	1.0	1.1	-1.4
Saline control response	0.0	0.0	0.1	0.1	-0.2	-0.2	-0.0	-0.2
Bone: connectivity density	1.0	1.6	1.9	-1.3	1.2	1.2	1.4	-1.2
Bone: cortical apparent density	1.0	1.6	1.8	-1.2	1.3	1.3	1.2	-1.3
Bone: cortical area	0.2	0.2	0.3	-0.5	0.6	0.6	0.6	-0.3
Bone: cortical porosity	1.0	1.1	1.3	-1.1	1.0	1.0	1.1	-1.0
Bone: cortical porosity	1.5	1.7	1.8	-1.3	1.3	1.3	1.3	-1.2
Bone: cortical thickness	2.0	3.4	3.9	-1.8	2.0	2.0	1.9	-1.6
Bone: cortical thickness	0.9	1.1	1.4	-1.0	1.2	1.2	1.1	-0.9
Bone: cortical tissue density	0.9	1.5	1.7	-1.2	1.2	1.2	1.2	-1.3
Condit. Reinf. active minus inactive responses	0.0	0.0	0.0	-0.2	0.1	0.1	0.2	-0.2
Condit. Reinf. active-inactive response ratio	0.5	0.5	0.6	-0.7	0.7	0.7	0.7	-0.8
Condit. Reinf. active responses	0.3	0.4	0.5	0.5	-0.7	-0.7	-0.5	0.5
Condit. Reinf. inactive responses	0.9	1.2	1.5	1.0	-1.2	-1.2	-1.0	1.0
Incentive salience index mean	0.0	0.0	0.1	-0.2	0.1	0.1	0.2	-0.1
Condit. Reinf. lever presses	0.1	0.1	0.1	-0.4	0.4	0.4	0.4	-0.2
Condit. Reinf. active minus inactive responses	2.1	3.2	3.5	1.8	-1.9	-1.8	-1.6	1.9
Condit. Reinf. active-inactive response ratio	0.6	1.0	1.2	1.0	-1.1	-1.1	-0.8	1.0
Condit. Reinf. active responses	1.0	1.5	1.8	1.2	-1.3	-1.3	-1.0	1.3
Condit. Reinf. inactive responses	0.1	0.1	0.2	-0.4	0.3	0.3	0.3	-0.1
Condit. Reinf. lever presses	0.9	1.4	2.1	-1.3	1.0	1.0	1.4	-1.0
Condit. Reinf. lever reinforcers received	0.6	0.9	1.1	0.9	-1.0	-1.0	-0.7	1.1
Conditioned reinforcement - actives	0.2	0.7	0.9	0.9	-0.9	-0.9	-0.8	0.4
Conditioned reinforcement - inactives	0.0	0.0	0.0	-0.1	0.1	0.1	0.0	-0.1
Conditioned locomotion	0.0	0.1	0.3	-0.1	0.0	0.0	0.1	-0.6
Patch foraging indifference point 0 sec	0.1	0.2	0.3	0.4	-0.5	-0.5	-0.2	0.5
Patch foraging indifference point AUC	0.0	0.0	0.2	-0.1	0.1	0.1	-0.0	0.4
Delay disc. indifference point, 0s delay	0.3	0.3	0.7	-0.4	0.4	0.4	0.5	-0.8
Delay disc. indifference point, 16s delay	0.0	0.0	0.1	0.0	0.1	0.0	-0.1	-0.4
Delay disc. indifference point, 2s delay	0.0	0.0	0.0	0.1	-0.2	-0.2	-0.1	-0.2
Delay disc. indifference point, 24s delay	0.1	0.2	0.6	-0.3	0.3	0.3	0.3	-0.8
Delay disc. indifference point, 4s delay	0.1	0.1	0.2	-0.2	-0.1	-0.1	0.2	-0.5
Delay disc. indifference point, 8s delay	0.1	0.1	0.2	0.3	-0.4	-0.4	-0.4	0.1
Indifference point function ln k	0.2	0.5	0.7	0.8	-0.8	-0.8	-0.8	0.4
Indifference point function log k	0.2	0.5	0.7	0.8	-0.8	-0.8	-0.8	0.4
Patch foraging total patch changes 0 sec	0.1	0.3	0.4	0.4	-0.6	-0.6	-0.3	0.6
Patch foraging total patch changes 12 sec	0.0	0.0	0.1	-0.2	0.1	0.1	0.4	0.0
Patch foraging total patch changes 18 sec	0.0	0.1	0.1	0.4	-0.4	-0.4	-0.2	0.3
Patch foraging total patch changes 24 sec	0.0	0.0	0.1	-0.1	-0.0	-0.0	0.2	0.3
Patch foraging total patch changes 6 sec	0.3	0.5	0.8	0.5	-0.8	-0.7	-0.6	0.9
Patch foraging time to switch 0 sec	0.5	1.8	2.7	-1.3	1.3	1.2	1.2	-1.6
Patch foraging water rate 0 sec	0.9	3.4	4.0	1.8	-1.9	-1.9	-1.7	2.0
Patch foraging water rate 12 sec	1.3	5.1	6.3	2.2	-2.2	-2.2	-2.1	2.5
Patch foraging water rate 18 sec	0.2	0.4	0.5	0.6	-0.7	-0.7	-0.5	0.6
Patch foraging water rate 24 sec	0.3	0.4	0.8	0.6	-0.5	-0.5	-0.6	0.9
Patch foraging water rate 6 sec	1.3	1.9	2.0	1.4	-1.4	-1.4	-1.3	1.4
Seeking ratio, delayed vs. immediate footshock	0.4	0.6	0.8	0.7	-0.8	-0.8	-0.8	0.9
Distance traveled before self-admin	0.1	0.3	0.5	0.7	-0.6	-0.6	-0.6	-0.0
Distance traveled after self-admin	0.9	1.6	1.8	1.4	-1.3	-1.3	-1.4	1.1
Extensor digitorum longus weight	8.4	33.5	34.7	5.9	-5.8	-5.8	-5.7	5.9
Bone: elastic displacement	0.4	0.6	0.6	0.8	-0.8	-0.8	-0.7	0.8
Bone: elastic work	0.0	0.0	0.0	0.1	0.0	0.0	0.0	0.2
Bone: endosteal estimation	1.8	4.4	4.6	2.2	-2.1	-2.1	-2.1	2.1
Bone: endosteal perimeter	2.7	6.5	7.0	2.6	-2.5	-2.5	-2.6	2.6
Epididymis fat weight	0.0	0.0	0.0	0.2	-0.2	-0.2	-0.0	-0.1
Delta time in closed arm before/after self-admin	1.6	1.5	1.6	-1.2	1.3	1.3	1.3	-1.1
Delta time in open arm before/after self-admin	0.2	0.2	0.3	-0.4	0.5	0.5	0.5	-0.3
Diff in mean of infusions in LGA sessions	0.9	1.6	1.8	1.2	-1.3	-1.3	-1.1	1.3
Delay discount exponential model param	0.1	0.1	0.2	-0.3	0.4	0.4	0.4	0.1
Extinction: sum of active levers before priming	0.3	0.5	0.5	0.6	-0.7	-0.7	-0.7	0.7
Active lever presses in extinction session 6	0.7	0.7	0.8	0.8	-0.8	-0.8	-0.9	0.7
Bone: final force	0.1	0.1	0.4	0.2	-0.2	-0.2	-0.2	0.6
Bone: final moment	0.0	0.1	0.1	-0.2	0.3	0.3	0.2	0.2
Food consumed during 24 hour testing period	0.7	1.3	1.5	1.2	-1.2	-1.2	-1.1	0.9
Glucose	0.7	1.1	1.2	1.1	-1.0	-1.0	-1.1	1.1
Heart weight	1.5	2.4	2.7	1.6	-1.6	-1.7	-1.6	1.1
Delay discount hyperbolic model param	0.0	0.1	0.1	-0.2	0.3	0.3	0.2	0.2
Intermittent access intake day 1-15 change	0.1	0.5	0.8	-0.7	0.7	0.7	0.9	-0.7
Intermittent access intake escalation	0.1	0.4	0.7	-0.7	0.6	0.6	0.8	-0.5
Intermittent access intake escalation 2	0.0	0.1	0.1	0.3	-0.2	-0.3	-0.2	0.2
Intermitt. access day 1 inactive lever presses	0.3	4.2	5.1	-2.0	2.0	2.0	2.1	-2.3
Intermitt. access day 15 inactive lever presses	0.1	0.3	0.4	0.6	-0.7	-0.7	-0.5	0.0
Intermitt. access escalation Index	0.2	0.5	0.7	0.7	-0.7	-0.7	-0.9	0.7
Intermittent access day 1 total infusions	0.2	0.7	0.9	-0.9	0.9	0.9	0.8	-0.7
Intermittent access day 15 total infusions	0.6	1.4	1.9	-1.3	1.2	1.1	1.4	-0.9
Intermittent access terminal intake (last 3 days)	0.2	0.3	0.5	-0.7	0.6	0.6	0.7	-0.3
Intermittent access total infusions	0.2	0.2	0.3	-0.5	0.4	0.4	0.5	-0.3
Intermittent access day 1 locomotion	1.5	2.7	3.1	-1.7	1.5	1.5	1.8	-1.7
Intermittent access day 15 total locomotion	0.5	2.1	2.9	-1.4	1.3	1.3	1.6	-1.7
Intermittent access total locomotion	0.0	0.1	0.1	0.0	-0.2	-0.2	0.2	-0.4
Intermittent access standard deviation	0.0	0.2	0.3	-0.5	0.4	0.4	0.5	-0.5
Left kidney weight	1.2	9.6	10.3	3.2	-3.2	-3.2	-3.0	2.9
Right kidney weight	1.9	13.0	13.8	3.7	-3.7	-3.7	-3.7	3.3
Cocaine induced anxiety	0.0	0.0	0.1	-0.2	0.1	0.1	0.2	-0.3
Post-drug Anxiety	2.2	2.5	2.9	-1.5	1.6	1.5	1.5	-1.7
Baseline Anxiety	0.8	1.3	1.4	-1.1	1.2	1.2	1.1	-1.2
Tail length	0.0	0.0	0.1	-0.0	-0.2	-0.1	0.0	0.2
Length with tail	0.5	2.4	3.0	1.4	-1.6	-1.6	-1.4	1.7
Length without tail	2.0	10.7	11.2	3.3	-3.3	-3.3	-3.3	3.2
Times rat made contact with spout	0.2	0.2	0.5	-0.3	0.4	0.4	0.3	-0.7
Lifetime Intake	0.1	0.1	0.2	-0.5	0.4	0.4	0.4	-0.1
Liver weight, left	3.1	5.4	5.8	2.3	-2.4	-2.4	-2.2	2.4
Liver weight, right	0.8	1.3	1.7	1.2	-1.0	-1.0	-1.3	1.3
Locomotor activity	6.9	10.8	11.2	3.3	-3.3	-3.3	-3.3	3.1
Locomotor testing distance	3.0	7.4	7.8	2.8	-2.8	-2.8	-2.8	2.5
Locomotor testing rearing	1.1	3.9	4.2	1.9	-2.1	-2.1	-1.9	1.9
Locomotion in novel chamber	0.3	0.4	0.6	-0.6	0.4	0.4	0.8	-0.8
Locomotion in novel chamber post-restriction	0.2	0.6	0.9	-0.8	0.8	0.8	0.7	-0.9
Fecal boli incidents, locomotor time 1	0.0	0.0	0.0	-0.0	-0.0	-0.0	0.2	0.1
Change in fecal boli incidents, locomotor task	0.0	0.0	0.0	0.0	0.1	0.1	-0.2	0.2
Time >=10cm from walls, locomotor time 1	0.2	0.2	0.3	0.6	-0.4	-0.4	-0.5	0.3
Bouts of movement, locomotor time 1	0.0	0.0	0.1	0.2	-0.1	-0.1	0.1	0.2
Total resting periods, locomotor time 1	0.0	0.0	0.1	0.2	-0.2	-0.2	0.1	0.3
Rest time, locomotor task time 1	0.0	0.0	0.1	-0.0	0.1	0.1	0.1	0.3
Distance moved, locomotor task time 1	0.0	0.1	0.2	-0.3	0.3	0.3	0.1	-0.5
Vertical activity count, locomotor time 1	0.0	0.2	0.6	-0.3	0.3	0.3	0.2	-0.8
Time >=10cm from walls, locomotor time 2	0.0	0.0	0.0	-0.1	0.2	0.2	0.1	-0.0
Bouts of movement, locomotor time 2	0.7	2.2	2.3	1.5	-1.4	-1.5	-1.5	1.5
Total resting periods, locomotor time 2	0.6	2.5	2.7	1.6	-1.5	-1.5	-1.5	1.6
Rest time, locomotor task time 2	0.1	0.2	0.3	-0.4	0.5	0.5	0.6	-0.2
Distance moved, locomotor task time 2	0.1	0.1	0.1	-0.3	0.3	0.3	0.2	-0.3
Vertical activity count, locomotor time 2	0.2	0.4	1.1	-0.5	0.5	0.5	0.4	-1.0
Light reinforcement 1	1.1	4.9	5.4	2.3	-2.2	-2.2	-2.3	2.1
Light reinforcement 2	0.2	0.4	0.4	-0.7	0.6	0.6	0.5	-0.6
Bone: marrow area	1.8	4.4	4.6	2.1	-2.1	-2.1	-2.1	2.1
Bone: maximum diameter	1.4	2.9	3.3	1.8	-1.6	-1.6	-1.7	1.8
Bone: maximum force	0.1	0.2	0.4	0.4	-0.3	-0.3	-0.4	0.6
Bone: maximum moment	0.0	0.0	0.0	-0.0	0.1	0.1	0.0	0.2
Mean time between licks in bursts	0.1	0.3	0.6	-0.5	0.6	0.6	0.3	-0.8
Mean num. licks in bursts	0.5	1.5	1.9	1.2	-1.4	-1.4	-1.1	0.8
Cd content in liver	1.2	1.4	1.5	-1.1	1.2	1.2	1.1	-1.2
Co content in liver	1.2	1.4	1.5	-1.1	1.2	1.2	1.1	-1.2
Cu content in liver	0.0	0.0	0.1	-0.1	0.3	0.3	-0.0	0.0
Fe content in liver	0.1	0.2	0.2	0.5	-0.4	-0.4	-0.3	0.4
K content in liver	1.6	1.6	1.7	1.2	-1.3	-1.3	-1.2	1.3
Mg content in liver	1.5	1.6	1.8	1.2	-1.2	-1.3	-1.2	1.4
Mn content in liver	0.0	0.0	0.1	-0.2	0.2	0.2	0.1	-0.2
Na content in liver	6.7	7.5	8.4	2.8	-2.7	-2.7	-2.7	2.9
Rb content in liver	0.6	0.7	0.7	0.8	-0.8	-0.8	-0.8	0.8
Se content in liver	0.0	0.0	0.1	-0.1	0.1	0.1	0.3	-0.3
Sr content in liver	0.0	0.0	0.0	-0.2	0.2	0.2	0.2	-0.2
Zn content in liver	0.0	0.0	0.0	0.1	-0.1	-0.1	-0.1	0.2
Bone: minimum diameter	0.1	0.1	0.2	-0.3	0.2	0.2	0.4	-0.4
Time in familiar zone, hab. session 1	0.1	0.1	0.1	-0.3	0.2	0.3	0.2	-0.0
Time in novel zone, hab. session 1	0.0	0.0	0.0	0.0	0.1	0.1	-0.0	-0.1
Total zone transitions, hab. session 1	0.8	1.1	1.2	-1.1	1.1	1.1	1.1	-0.9
Total locomotion distance, hab. session 1	0.1	0.2	0.2	-0.4	0.4	0.4	0.4	-0.4
Locomotion velocity, hab. session 1	0.0	0.0	0.0	-0.1	0.1	0.1	0.1	-0.1
Time in familiar zone, hab. session 2	0.1	0.1	0.1	-0.3	0.4	0.4	0.1	0.1
Time in novel zone, hab. session 2	0.0	0.0	0.2	-0.0	-0.0	-0.0	0.2	-0.4
Total zone transitions, hab. session 2	0.1	0.2	0.4	0.4	-0.2	-0.2	-0.5	0.6
Total locomotion distance, hab. session 2	0.6	0.8	1.0	0.9	-0.8	-0.8	-1.0	0.9
Locomotion velocity, hab. session 2	0.2	0.3	0.5	0.6	-0.4	-0.4	-0.7	0.6
Novel to familiar place preference ratio	1.1	1.4	1.7	1.1	-1.3	-1.3	-1.0	1.1
Novelty place preference	1.0	1.3	1.7	1.1	-1.3	-1.3	-1.0	1.1
Time in novel zone, NPP test	1.3	1.6	2.0	1.2	-1.4	-1.4	-1.1	1.2
Total zone transitions, NPP test	0.1	0.1	0.1	0.3	-0.4	-0.4	-0.2	0.4
Total locomotion distance, NPP test	0.4	0.6	0.7	0.7	-0.8	-0.8	-0.7	0.8
Locomotion velocity, NPP test	0.1	0.2	0.2	0.4	-0.5	-0.5	-0.4	0.4
Intraocular pressure	0.0	0.0	0.1	0.2	-0.0	-0.0	-0.3	0.1
Delta distance traveled before/after self-admin	0.7	0.8	1.2	0.8	-0.8	-0.8	-0.8	1.1
Delta ambulatory time before/after self-admin	0.1	0.2	0.4	0.4	-0.4	-0.4	-0.3	0.6
Parametrial fat weight	1.1	2.6	3.6	-1.6	1.9	1.9	1.3	-1.3
Pavlov. Cond. lever latency	0.1	0.1	0.1	-0.3	0.3	0.3	0.1	-0.3
Pavlov. Cond. magazine entry latency	0.9	1.1	1.2	-1.1	1.1	1.1	1.1	-0.8
Pavlov. Cond. change in total contacts	0.0	0.0	0.0	0.1	-0.1	-0.1	0.2	-0.1
Pavlov. Cond. index score	0.6	0.8	1.0	-0.9	0.9	0.9	1.0	-0.7
Pavlov. Cond. latency score	0.3	0.3	0.6	-0.6	0.6	0.6	0.7	-0.4
Pavlov. Cond. lever contacts	0.0	0.0	0.0	-0.1	0.1	0.1	0.2	0.1
Pavlov. Cond. magazine entry number	1.1	1.4	1.5	1.2	-1.2	-1.2	-1.2	1.0
Pavlov. Cond. intertrial magazine entries	0.1	0.1	0.1	0.2	-0.3	-0.3	-0.4	0.3
Pavlov. Cond. lever-magazine prob. diff.	0.3	0.4	0.6	-0.7	0.7	0.7	0.8	-0.4
Pavlov. Cond. response bias	0.4	0.5	0.6	-0.7	0.8	0.8	0.8	-0.6
Pavlov. Cond. lever latency	0.6	0.8	1.2	1.0	-0.8	-0.8	-1.1	0.7
Pavlov. Cond. magazine entry latency	3.4	4.8	5.3	-2.2	2.1	2.1	2.3	-2.2
Pavlov. Cond. change in total contacts	0.4	0.9	1.1	-1.0	0.8	0.8	1.1	-1.0
Pavlov. Cond. index score	1.2	1.8	2.2	-1.4	1.3	1.3	1.5	-1.2
Pavlov. Cond. latency score	0.7	1.2	1.5	-1.1	1.0	1.0	1.2	-1.0
Pavlov. Cond. lever contacts	0.5	0.7	1.0	-0.9	0.8	0.8	1.0	-0.7
Pavlov. Cond. magazine entry number	4.0	5.2	5.5	2.3	-2.3	-2.3	-2.3	2.2
Pavlov. Cond. intertrial magazine entries	0.6	1.3	1.5	1.2	-1.2	-1.2	-1.2	1.0
Pavlov. Cond. lever-magazine prob. diff.	1.4	2.1	2.4	-1.5	1.4	1.4	1.6	-1.3
Pavlov. Cond. response bias	1.9	2.7	3.2	-1.7	1.6	1.6	1.8	-1.5
Time in closed arm before self-admin	0.0	0.0	0.0	0.2	-0.1	-0.2	-0.1	-0.2
Time in closed arm after self-admin	0.4	0.4	0.5	-0.6	0.6	0.6	0.7	-0.7
Time in open arm before self-admin	0.5	0.6	0.8	0.7	-0.8	-0.8	-0.9	0.7
Time in open arm after self-admin	0.2	0.2	0.4	0.4	-0.5	-0.5	-0.5	0.6
Bone: periosteal estimation	0.7	1.7	2.0	1.3	-1.2	-1.2	-1.2	1.4
Bone: periosteal perimeter	1.3	2.5	2.9	1.6	-1.5	-1.5	-1.5	1.7
Bone: post-yield work	0.0	0.1	0.1	0.3	-0.2	-0.3	-0.3	0.2
Progressive ratio test 1 active lever presses	0.0	0.1	0.1	-0.4	0.3	0.3	0.2	0.0
Progressive ratio test 1 breakpoint	0.1	0.1	0.2	-0.4	0.4	0.4	0.3	-0.1
Progressive ratio test 1 inactive lever presses	1.4	3.6	4.0	-2.0	2.0	2.0	1.8	-1.7
Progressive ratio test 2 active lever presses	0.2	0.3	0.3	0.5	-0.6	-0.6	-0.5	0.5
Progressive ratio test 2 breakpoint	0.2	0.2	0.3	0.5	-0.5	-0.5	-0.4	0.4
Progressive ratio test 2 inactive lever presses	0.0	0.1	0.2	-0.3	0.3	0.3	0.4	-0.4
Incentive Sensitization - Responses	0.2	0.4	0.6	0.7	-0.8	-0.8	-0.6	0.3
Incentive Sensitization - Breakpoint	0.1	0.3	0.4	0.6	-0.6	-0.6	-0.4	0.2
Sum of active levers in priming session hrs 5-6	0.2	0.2	0.2	0.4	-0.5	-0.5	-0.4	0.4
Progressive ratio	0.2	0.6	0.9	-0.7	0.8	0.7	0.8	-0.9
Food seeking constrained by brief footshock	0.2	0.2	0.3	0.5	-0.4	-0.4	-0.5	0.6
Seeking ratio, punishment vs. effort	1.7	3.7	4.7	1.8	-1.9	-1.9	-1.9	2.2
Retroperitoneal fat weight	0.1	0.5	0.6	-0.6	0.8	0.8	0.6	-0.7
Reaction time number correct	0.7	2.5	2.9	1.6	-1.5	-1.5	-1.7	1.5
Reaction time mean minus median	0.0	0.2	0.4	-0.5	0.3	0.3	0.7	-0.0
Reaction time mean minus median AUC	0.1	0.9	1.3	-1.0	1.0	1.0	1.1	-0.5
Reaction time num false alarms	0.5	0.9	1.3	-0.9	1.1	1.1	0.8	-0.7
Reaction time num false alarms AUC	0.2	0.4	0.6	-0.6	0.8	0.8	0.5	-0.4
Reaction time trials correct on left	0.7	2.5	2.9	1.6	-1.5	-1.5	-1.7	1.5
Reaction time trials on left	0.8	2.7	3.1	1.7	-1.6	-1.6	-1.7	1.6
Reaction time mean	1.8	4.0	4.5	-2.1	2.0	2.0	2.1	-1.6
Reaction time mean AUC	1.1	2.8	3.1	-1.8	1.7	1.7	1.8	-1.3
Median of all reaction times	4.2	6.6	7.0	-2.6	2.6	2.7	2.6	-2.2
Reaction time omissions	0.1	0.2	0.4	0.4	-0.4	-0.4	-0.4	0.6
Reaction time false alarm rate	1.6	2.3	2.7	-1.5	1.6	1.6	1.5	-1.3
Reaction time premature initiation rate	1.5	2.4	2.7	1.6	-1.4	-1.4	-1.6	1.7
Reaction time premature initiations	1.3	4.1	4.4	2.1	-1.9	-1.9	-2.1	2.1
Std. dev. reaction times	0.4	1.4	1.9	-1.3	1.2	1.2	1.4	-0.7
Reaction time trials completed	0.8	2.7	3.1	1.7	-1.6	-1.6	-1.7	1.6
Reaction time trials AUC	0.7	2.3	2.7	1.6	-1.4	-1.4	-1.6	1.4
Run reversals in cocaine runway, females	0.0	0.0	0.1	-0.2	0.1	0.2	0.1	-0.3
Run reversals in cocaine runway, males	0.0	0.0	0.0	0.1	-0.0	-0.0	-0.1	0.2
Latency to leave start box in cocaine runway	2.5	3.5	4.0	1.9	-2.0	-2.0	-1.9	1.6
Latency to leave start box in cocaine runway, F	0.8	1.1	1.3	1.1	-1.1	-1.1	-0.9	0.8
Latency to leave start box in cocaine runway, M	6.6	6.3	7.0	2.5	-2.5	-2.5	-2.6	2.3
Std. dev. time between licks in bursts	0.1	0.3	0.3	0.4	-0.5	-0.5	-0.5	0.6
Total sessions with >9 infusions	0.2	0.3	0.4	-0.6	0.7	0.7	0.5	0.1
Short access day 1 total inactive lever presses	0.4	0.7	0.9	-0.8	0.9	0.9	0.8	-0.8
Short access day 10 total inactive lever presses	0.2	1.3	2.3	-1.0	1.0	1.0	1.1	-1.5
Short access day 1 total infusions	0.0	0.1	0.1	-0.2	0.3	0.3	0.2	-0.0
Short access day 10 total infusions	0.8	1.4	1.8	-1.3	1.3	1.3	1.2	-0.7
Short access total infusions	0.4	0.6	0.8	-0.9	0.9	0.9	0.7	-0.4
Short access day 1 locomotion	0.0	0.0	0.1	-0.2	0.3	0.3	0.0	0.0
Short access day 10 total locomotion	0.2	0.8	1.0	-0.9	0.8	0.8	1.0	-0.8
Short access total locomotion	0.4	0.5	0.6	-0.8	0.8	0.8	0.7	-0.5
One hour access (0.3 mA shock)	0.9	1.1	1.2	1.0	-1.0	-1.0	-1.1	1.1
Compulsive drug intake	0.9	1.4	1.8	1.2	-1.1	-1.1	-1.3	1.1
One hour access (shock baseline)	0.0	0.1	0.1	-0.4	0.3	0.3	0.3	-0.1
Social response proportion	0.1	0.2	0.5	-0.4	0.1	0.1	0.4	-0.7
Social responses	0.0	0.0	0.0	-0.1	-0.1	-0.1	0.2	-0.2
Social time	0.0	0.0	0.1	0.1	-0.3	-0.3	0.0	-0.0
Soleus weight	16.9	49.8	50.1	7.1	-7.1	-7.1	-7.0	7.1
Bone: stiffness	0.5	0.8	0.9	0.9	-0.9	-0.9	-0.8	0.9
Tibialis anterior weight	13.7	47.2	49.3	6.9	-6.8	-6.8	-6.8	7.0
Time to tail flick, vehicle, before self-admin	0.3	0.4	0.6	-0.7	0.6	0.6	0.8	-0.5
Time to tail flick, vehicle, after self-admin	0.3	0.6	1.5	-0.5	0.6	0.6	0.8	-1.2
Time to tail flick, test, before self-admin	2.1	2.4	2.7	-1.7	1.6	1.6	1.6	-1.2
Time to tail flick, test, after self-admin	1.5	1.6	3.2	-1.0	1.1	1.1	1.0	-1.8
Delta time to tail flick, vehicle, before/after SA	0.4	0.4	1.0	-0.4	0.5	0.5	0.5	-1.0
Delta time to tail flick, test, before/after SA	0.3	0.3	0.4	0.7	-0.6	-0.6	-0.7	0.0
Tibia length	0.1	0.2	0.4	-0.3	0.2	0.2	0.5	-0.6
Ambulatory time before self-admin	0.0	0.0	0.1	0.2	-0.1	-0.1	-0.2	-0.2
Ambulatory time after self-admin	0.3	0.6	0.6	0.8	-0.7	-0.7	-0.8	0.7
Bone: tissue strength	1.4	1.4	1.5	-1.2	1.2	1.2	1.2	-1.2
Total heroin consumption	2.2	2.6	2.9	1.6	-1.6	-1.6	-1.6	1.7
Bone: trabecular number	1.4	2.6	2.9	-1.7	1.6	1.6	1.7	-1.5
Bone: trabecular spacing	0.0	0.1	0.1	0.3	-0.2	-0.2	-0.3	0.2
Bone: trabecular thickness	0.5	0.7	0.8	-0.8	0.9	0.9	0.8	-0.7
Bone: trabecular tissue density	3.4	6.0	7.1	2.4	-2.3	-2.3	-2.5	2.7
Water consumed over 24 hours	0.1	0.2	0.2	-0.4	0.5	0.5	0.5	-0.5
Number of responses in last shaping day	0.0	0.0	0.1	0.1	-0.3	-0.3	-0.0	-0.1