Hub : Genes

Ltbp1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Brain gene expression Ltbp1 0.49 0.11 0.0e+00 0.36 0.41 0.4 0.4 3.9e-35 2.1e-40 3.8e-39 2.9e-40
2 pVTA gene expression Ltbp1 0.24 0.08 0.0e+00 0.18 0.22 0.22 0.23 4.2e-14 9.9e-18 3.5e-17 1.0e-18
3 Adipose mRNA stability Ltbp1 0.23 0.08 0.0e+00 0.14 0.18 0.17 0.17 6.7e-15 2.9e-19 2.1e-18 1.4e-18
4 BLA gene expression Ltbp1 0.18 0.07 1.4e-09 0.13 0.14 0.14 0.14 1.9e-07 4.9e-08 6.2e-08 6.4e-08
5 Liver gene expression Ltbp1 0.13 0.05 7.6e-15 0.07 0.1 0.1 0.06 3.3e-08 5.4e-11 2.4e-11 9.4e-07
6 PL gene expression Ltbp1 0.25 0.06 0.0e+00 0.2 0.29 0.28 0.28 1.6e-21 1.0e-31 3.1e-30 7.9e-31
7 LHb gene expression Ltbp1 0.38 0.13 7.9e-08 0.27 0.34 0.38 0.37 3.6e-07 6.0e-09 4.4e-10 9.9e-10
8 NAcc gene expression Ltbp1 0.09 0.05 8.5e-13 0.1 0.09 0.1 0.1 3.0e-15 1.4e-13 2.1e-14 1.7e-14
9 IC gene expression Ltbp1 0.26 0.08 6.0e-12 0.23 0.27 0.25 0.25 5.3e-10 1.3e-11 1.0e-10 6.2e-11
10 IL gene expression Ltbp1 0.31 0.12 5.2e-05 0.17 0.17 0.2 0.21 7.1e-05 7.9e-05 1.6e-05 8.3e-06
11 Liver alternative TSS XM_063262393.1 0.05 0.04 1.5e-03 0.01 0.01 0.02 0.01 1.5e-02 1.0e-02 1.6e-03 1.0e-02
12 Adipose gene expression Ltbp1 0.22 0.07 0.0e+00 0.18 0.2 0.2 0.19 2.3e-19 6.2e-22 1.5e-21 1.1e-20
13 Adipose alternative TSS XM_063262390.1 0.03 0.02 3.1e-03 -0 0 0.01 0 5.9e-01 3.2e-01 2.9e-02 3.4e-01

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13
Bone: apparent density4.57.812.5-3.0-3.1-0.6-2.9-3.5-3.2-2.7-2.3-3.2-2.82.1-3.0-2.5
Area under the delay curve0.10.10.70.20.1-0.20.20.40.40.00.30.10.2-0.80.10.1
BMI with tail2.07.110.7-3.0-3.0-3.0-3.3-3.1-3.0-3.1-2.9-2.6-2.81.0-1.3-0.8
BMI without tail1.23.55.4-2.3-2.1-2.3-2.2-2.2-2.1-2.0-1.5-1.9-2.00.5-1.4-0.2
Body weight0.10.63.6-0.0-0.0-1.9-0.3-0.1-0.2-0.6-0.10.4-0.2-0.91.21.3
Weight adjusted by age1.21.84.8-1.2-0.91.1-0.8-1.3-1.5-0.4-0.7-1.3-1.21.6-2.2-2.1
Bone surface1.22.23.6-1.5-1.50.2-1.4-1.9-1.6-1.2-1.2-1.7-1.61.7-1.8-1.5
Bone volume1.42.64.7-1.7-1.8-0.0-1.6-2.2-1.9-1.4-1.2-1.8-1.61.4-1.9-1.1
Breakpoint value in progressive ratio session0.91.12.6-1.2-1.1-0.8-1.2-1.0-1.1-0.7-0.9-1.1-1.00.1-1.2-1.6
Number of licking bursts0.30.41.3-0.3-0.60.2-0.7-0.6-0.7-1.0-0.5-0.7-0.91.1-0.2-0.2
Context. condit. distance diff. score0.91.12.11.21.10.71.11.21.11.20.71.21.4-0.21.00.7
Locomotion velocity, session 11.71.82.9-1.4-1.5-1.5-1.7-1.5-1.4-1.6-1.4-1.3-1.70.1-0.5-0.7
Locomotion distance, session 11.31.75.5-1.4-1.3-2.3-1.5-1.2-1.2-1.6-0.7-1.0-1.90.1-0.30.0
Locomotion velocity, session 20.40.51.1-0.6-0.9-1.1-0.8-0.8-0.5-1.0-0.7-0.5-0.50.00.3-0.2
Locomotion distance, session 21.21.73.2-1.5-1.6-1.8-1.5-1.6-1.2-1.2-1.3-1.2-1.40.5-0.5-0.4
Locomotion velocity, session 31.01.11.7-1.3-1.1-1.3-1.1-1.2-1.2-1.1-0.6-1.0-1.3-0.3-1.1-0.4
Locomotion distance, session 32.42.65.0-1.9-1.8-2.2-1.9-1.9-1.6-1.9-1.5-1.5-1.70.1-1.0-0.9
Stereotopy head waving bouts, day 30.00.00.10.30.20.3-0.10.20.1-0.0-0.30.2-0.0-0.20.20.2
Stereotopy head waving duration, day 30.70.81.51.21.00.90.81.01.00.90.40.90.9-1.00.70.5
Locomotion velocity, session 74.55.07.5-2.6-2.6-2.7-2.7-2.6-2.4-2.5-2.1-2.1-2.5-0.1-1.3-0.8
Locomotion distance, session 71.82.23.4-1.8-1.8-1.5-1.9-1.8-1.6-1.8-1.7-1.5-1.40.0-0.6-0.6
Stereotopy head waving bouts, day 70.10.20.90.10.31.00.20.40.10.3-0.10.10.60.5-0.3-0.3
Stereotopy head waving duration, day 70.10.10.50.20.20.70.00.30.20.2-0.40.20.50.10.0-0.4
Locomotion velocity, session 82.83.45.2-2.1-2.2-1.9-2.3-2.2-1.9-1.9-2.1-1.7-2.01.0-0.9-0.6
Locomotion distance, session 80.20.30.7-0.5-0.6-0.8-0.6-0.5-0.4-0.4-0.8-0.2-0.20.70.40.2
Degree of sensitization distance0.20.21.30.50.31.10.30.30.10.1-0.10.10.30.60.50.2
Degree of sensitization stereotypy0.20.20.80.40.50.50.50.60.50.60.30.50.90.10.40.3
Conditioned locomotion1.51.72.6-1.4-1.5-0.5-1.5-1.6-1.5-1.3-1.3-1.5-1.31.4-1.1-0.6
Cocaine response after cond. corrected1.31.62.4-1.3-1.4-0.7-1.6-1.3-1.3-1.5-1.4-1.4-1.40.6-1.0-0.8
Cocaine response after cond. not corrected0.40.50.8-0.7-0.8-0.7-0.9-0.8-0.6-0.8-0.6-0.8-0.9-0.1-0.8-0.5
Cocaine response before conditioning2.53.05.11.91.90.01.91.62.22.32.12.01.5-1.80.90.8
Saline control response0.20.31.50.10.5-0.40.40.40.50.50.70.4-0.1-1.2-0.6-0.3
Bone: connectivity density4.97.711.4-2.9-3.1-0.5-3.0-3.4-3.0-2.5-2.3-3.1-2.92.4-3.1-2.8
Bone: cortical apparent density0.20.20.6-0.6-0.4-0.8-0.3-0.3-0.3-0.00.2-0.4-0.6-0.3-0.8-0.6
Bone: cortical area0.00.00.1-0.20.0-0.40.1-0.3-0.10.10.3-0.0-0.1-0.2-0.20.2
Bone: cortical porosity0.20.20.70.40.40.80.70.50.30.30.20.40.40.50.70.0
Bone: cortical porosity0.10.10.80.00.10.80.30.2-0.1-0.1-0.1-0.00.10.90.50.1
Bone: cortical thickness0.10.10.6-0.10.2-0.40.4-0.00.00.20.70.10.4-0.8-0.10.3
Bone: cortical thickness0.60.71.4-1.2-0.9-1.0-0.8-1.2-1.0-0.9-0.4-1.0-0.9-0.0-0.6-0.4
Bone: cortical tissue density0.10.20.6-0.5-0.3-0.6-0.2-0.3-0.20.00.2-0.4-0.6-0.2-0.8-0.6
Condit. Reinf. active minus inactive responses1.11.23.8-1.2-1.1-2.0-1.1-1.1-0.8-1.5-0.7-0.8-1.1-1.1-0.5-0.6
Condit. Reinf. active-inactive response ratio1.21.32.2-1.2-1.2-0.9-1.2-1.2-1.0-1.5-0.9-1.1-1.4-0.0-1.1-1.1
Condit. Reinf. active responses1.11.34.1-1.2-1.3-2.0-1.3-1.3-0.9-1.4-0.9-0.8-1.0-1.0-0.5-0.3
Condit. Reinf. inactive responses0.10.10.30.0-0.3-0.3-0.4-0.4-0.10.1-0.6-0.10.2-0.10.10.1
Incentive salience index mean0.81.03.2-1.1-1.0-1.8-1.0-1.1-0.8-1.3-0.6-0.7-1.0-0.8-0.3-0.1
Condit. Reinf. lever presses0.10.10.5-0.3-0.1-0.7-0.0-0.3-0.1-0.10.10.0-0.1-0.30.20.7
Condit. Reinf. active minus inactive responses0.20.21.5-0.3-0.3-1.2-0.4-0.3-0.1-0.3-0.3-0.1-0.4-0.50.20.1
Condit. Reinf. active-inactive response ratio0.30.40.70.60.7-0.50.50.40.80.60.50.80.4-0.80.80.5
Condit. Reinf. active responses0.20.31.5-0.10.2-1.20.10.30.30.30.40.2-0.2-1.2-0.00.4
Condit. Reinf. inactive responses0.20.21.1-0.7-0.4-1.1-0.2-0.0-0.3-0.20.1-0.3-0.5-0.7-0.60.1
Condit. Reinf. lever presses0.20.32.6-0.1-0.1-1.6-0.3-0.10.1-0.30.00.1-0.3-0.90.40.8
Condit. Reinf. lever reinforcers received0.20.32.4-0.5-0.3-1.6-0.3-0.1-0.0-0.20.1-0.1-0.6-1.0-0.20.2
Conditioned reinforcement - actives0.61.03.90.10.9-0.31.10.80.71.12.00.70.4-1.7-0.6-0.4
Conditioned reinforcement - inactives0.30.41.70.10.6-0.90.50.40.50.61.10.4-0.4-1.3-0.30.2
Conditioned locomotion1.51.97.40.31.4-1.31.41.01.11.72.71.10.3-2.2-0.50.8
Patch foraging indifference point 0 sec0.71.33.9-1.2-1.3-0.7-1.2-1.1-1.2-2.0-1.3-1.0-1.1-0.6-0.3-1.0
Patch foraging indifference point AUC0.30.41.3-0.4-0.3-0.2-0.5-0.5-0.7-0.40.0-0.7-1.10.7-1.1-0.9
Delay disc. indifference point, 0s delay1.21.32.90.81.11.01.51.51.31.40.91.11.7-0.50.70.3
Delay disc. indifference point, 16s delay0.10.11.0-0.1-0.1-0.3-0.1-0.00.0-0.2-0.0-0.10.0-1.0-0.1-0.1
Delay disc. indifference point, 2s delay0.20.21.4-0.00.20.10.50.60.40.40.60.10.4-1.2-0.3-0.3
Delay disc. indifference point, 24s delay0.10.10.5-0.3-0.5-0.7-0.4-0.3-0.1-0.4-0.4-0.2-0.0-0.7-0.1-0.1
Delay disc. indifference point, 4s delay0.50.51.00.90.61.00.80.81.00.80.70.60.80.10.20.2
Delay disc. indifference point, 8s delay0.10.20.9-0.2-0.3-0.9-0.3-0.00.0-0.5-0.2-0.1-0.1-0.40.50.7
Indifference point function ln k0.10.21.50.30.01.20.1-0.20.1-0.1-0.60.10.6-0.10.5-0.1
Indifference point function log k0.10.21.50.30.01.20.1-0.20.1-0.1-0.60.10.6-0.10.5-0.1
Patch foraging total patch changes 0 sec0.71.24.0-1.1-1.3-0.8-1.2-1.0-1.1-2.0-1.3-1.0-1.0-0.6-0.1-0.9
Patch foraging total patch changes 12 sec0.60.81.7-0.9-0.9-0.5-1.0-0.8-1.0-1.3-0.9-0.9-1.00.4-0.5-0.9
Patch foraging total patch changes 18 sec1.01.52.6-1.4-1.2-1.2-1.2-1.2-1.3-1.4-0.5-1.2-1.60.0-1.5-1.2
Patch foraging total patch changes 24 sec0.10.20.50.40.50.50.40.60.40.30.10.40.6-0.70.2-0.5
Patch foraging total patch changes 6 sec0.50.73.0-0.6-0.80.5-0.7-0.6-0.7-1.0-0.9-0.8-0.60.4-0.6-1.7
Patch foraging time to switch 0 sec0.61.13.8-1.3-1.3-2.0-1.2-1.2-1.0-0.9-0.7-0.9-1.00.1-0.6-0.1
Patch foraging water rate 0 sec0.30.61.51.11.01.20.80.90.70.20.50.70.6-0.80.70.4
Patch foraging water rate 12 sec2.04.26.92.32.31.12.12.22.21.71.42.32.5-1.32.62.1
Patch foraging water rate 18 sec2.53.96.22.52.51.62.22.12.11.81.62.22.0-1.11.91.6
Patch foraging water rate 24 sec1.21.63.31.71.51.21.10.91.30.90.21.41.6-1.11.80.9
Patch foraging water rate 6 sec1.21.73.71.51.61.01.31.21.21.10.71.41.5-0.21.91.6
Seeking ratio, delayed vs. immediate footshock0.81.03.00.60.9-1.00.90.20.61.01.71.10.1-1.40.31.4
Distance traveled before self-admin0.10.10.4-0.0-0.1-0.40.20.3-0.30.10.60.20.0-0.20.00.4
Distance traveled after self-admin0.30.41.5-0.70.1-0.50.40.9-0.10.40.50.20.3-1.1-0.3-1.2
Extensor digitorum longus weight2.610.317.8-3.9-3.5-4.2-3.5-3.6-3.5-3.3-2.1-3.1-4.20.7-2.6-1.1
Bone: elastic displacement0.00.10.30.30.10.5-0.0-0.20.0-0.2-0.10.1-0.00.40.3-0.2
Bone: elastic work0.20.30.8-0.6-0.6-0.5-0.6-0.9-0.6-0.7-0.6-0.4-0.20.30.2-0.1
Bone: endosteal estimation0.10.30.9-0.4-0.5-0.1-0.6-0.6-0.6-0.5-0.6-0.5-0.90.9-0.4-0.2
Bone: endosteal perimeter0.30.61.11.11.00.80.90.70.80.90.90.80.5-0.20.40.4
Epididymis fat weight0.51.79.11.41.13.01.00.70.60.1-0.10.71.70.91.5-1.2
Delta time in closed arm before/after self-admin0.60.62.6-0.7-0.80.3-0.8-0.6-0.7-0.7-1.6-0.60.01.10.2-0.2
Delta time in open arm before/after self-admin0.40.41.5-0.2-0.2-1.2-0.5-0.3-0.0-0.20.3-0.3-0.8-1.1-0.90.3
Diff in mean of infusions in LGA sessions1.31.65.4-1.4-1.00.2-0.8-1.0-1.3-0.6-0.0-1.3-1.40.6-2.3-2.3
Delay discount exponential model param0.10.10.50.00.20.40.1-0.1-0.20.2-0.00.10.00.7-0.00.1
Extinction: sum of active levers before priming0.30.41.1-0.5-0.80.2-0.6-0.5-0.5-0.7-0.9-0.50.20.50.1-1.0
Active lever presses in extinction session 61.61.52.91.01.31.51.51.01.11.21.70.90.8-1.6-0.6-1.6
Bone: final force1.01.52.5-1.6-1.4-0.6-1.1-1.6-1.6-1.3-0.8-1.4-1.40.7-1.1-1.0
Bone: final moment0.81.42.3-1.5-1.3-0.5-1.0-1.5-1.5-1.2-0.8-1.3-1.30.7-1.1-1.0
Food consumed during 24 hour testing period0.40.52.41.00.81.60.50.60.60.4-0.00.40.41.10.40.4
Glucose0.10.20.90.80.30.90.1-0.10.3-0.4-0.20.20.40.10.40.1
Heart weight1.42.15.71.31.5-0.31.41.61.31.00.91.71.4-0.92.42.1
Delay discount hyperbolic model param0.10.10.5-0.00.00.3-0.1-0.3-0.30.1-0.1-0.0-0.10.7-0.10.0
Intermittent access intake day 1-15 change0.10.21.30.80.31.10.40.20.20.20.20.30.6-0.10.40.2
Intermittent access intake escalation0.20.41.11.00.51.00.60.30.40.30.40.50.8-0.20.70.4
Intermittent access intake escalation 20.20.21.70.70.31.30.50.10.20.20.30.20.50.10.1-0.1
Intermitt. access day 1 inactive lever presses0.20.63.7-1.0-0.3-1.9-0.1-0.4-0.20.50.70.1-0.6-1.1-1.00.5
Intermitt. access day 15 inactive lever presses0.10.21.2-0.30.1-0.00.4-0.20.20.90.70.00.1-0.5-1.1-0.1
Intermitt. access escalation Index0.30.41.6-0.10.2-0.00.70.50.41.30.70.61.1-0.10.10.5
Intermittent access day 1 total infusions0.10.21.00.20.1-0.3-0.00.20.0-0.00.8-0.3-1.00.5-0.40.9
Intermittent access day 15 total infusions0.50.83.41.30.80.30.70.70.70.41.40.6-0.10.30.71.8
Intermittent access terminal intake (last 3 days)0.40.51.80.90.50.20.60.60.50.41.30.3-0.30.20.11.3
Intermittent access total infusions0.70.82.81.10.9-0.00.81.00.90.41.70.5-0.4-0.20.31.5
Intermittent access day 1 locomotion0.50.72.20.30.5-1.40.30.30.50.41.40.3-0.9-0.8-0.21.5
Intermittent access day 15 total locomotion0.30.62.50.40.4-0.90.40.10.40.41.50.4-0.5-0.9-0.21.6
Intermittent access total locomotion0.60.72.50.60.5-1.00.50.50.60.51.60.5-0.4-1.00.11.5
Intermittent access standard deviation1.02.13.51.71.90.81.71.51.71.71.61.61.3-1.10.91.0
Left kidney weight0.31.52.71.51.61.61.41.21.31.61.11.21.2-0.40.10.3
Right kidney weight0.31.52.71.51.61.21.31.11.21.41.01.21.3-0.90.60.7
Cocaine induced anxiety1.62.34.3-1.7-1.8-1.3-1.8-2.1-1.6-1.5-1.3-1.6-1.50.8-1.5-0.9
Post-drug Anxiety0.20.20.5-0.6-0.5-0.5-0.5-0.7-0.5-0.2-0.4-0.3-0.10.2-0.2-0.2
Baseline Anxiety0.91.01.81.01.11.01.31.20.91.21.11.01.2-0.00.80.5
Tail length1.14.48.62.02.51.12.72.42.12.52.92.21.8-1.70.81.0
Length with tail2.19.112.63.53.51.53.53.43.22.93.23.43.0-2.03.02.2
Length without tail1.65.110.23.02.50.82.32.52.41.51.72.72.2-1.43.21.8
Times rat made contact with spout1.82.13.41.61.70.31.51.31.81.30.91.71.5-1.91.50.8
Lifetime Intake0.60.72.71.10.8-0.20.60.90.80.31.40.5-0.4-0.00.51.6
Liver weight, left1.22.03.81.01.60.51.71.41.51.71.61.51.9-2.00.60.3
Liver weight, right0.61.11.81.21.31.31.21.20.90.70.81.01.30.01.30.3
Locomotor activity0.91.53.0-1.7-1.3-1.5-1.2-1.0-1.5-1.4-1.0-1.3-1.40.4-0.7-0.7
Locomotor testing distance1.42.64.0-2.0-1.8-1.9-1.8-1.8-1.9-1.7-1.3-1.6-2.00.8-0.8-0.8
Locomotor testing rearing0.30.63.9-0.5-0.4-2.0-0.7-0.4-0.3-0.7-0.2-0.3-1.1-0.40.40.1
Locomotion in novel chamber0.60.71.60.40.7-1.00.70.60.91.11.10.80.6-1.30.20.8
Locomotion in novel chamber post-restriction1.32.24.21.21.60.01.51.81.61.41.21.61.8-2.11.41.0
Fecal boli incidents, locomotor time 10.50.72.7-0.7-0.70.7-0.6-0.6-0.9-1.0-1.2-0.8-0.41.60.0-0.6
Change in fecal boli incidents, locomotor task1.91.93.71.91.50.51.41.21.71.21.31.51.4-0.61.51.4
Time >=10cm from walls, locomotor time 10.90.94.51.40.30.80.1-0.00.4-0.6-0.70.50.61.22.11.5
Bouts of movement, locomotor time 10.40.41.6-0.2-0.4-0.6-0.2-0.1-0.00.0-0.60.10.41.21.31.2
Total resting periods, locomotor time 10.50.62.70.2-0.2-0.2-0.10.00.20.0-0.70.30.61.41.61.5
Rest time, locomotor task time 10.60.84.10.3-0.30.4-0.20.10.0-0.6-1.20.20.51.72.01.0
Distance moved, locomotor task time 10.20.31.90.00.10.90.0-0.1-0.00.50.4-0.3-0.1-0.1-1.4-0.6
Vertical activity count, locomotor time 10.10.30.70.30.80.40.60.40.50.90.80.30.3-0.8-0.50.2
Time >=10cm from walls, locomotor time 20.71.03.61.50.51.80.20.30.4-0.3-0.50.20.11.91.41.0
Bouts of movement, locomotor time 21.52.37.21.91.41.11.31.41.60.90.21.62.00.92.71.5
Total resting periods, locomotor time 21.01.75.91.61.00.91.01.11.40.7-0.01.31.70.92.41.3
Rest time, locomotor task time 20.50.62.6-0.9-0.9-1.6-0.8-0.9-0.5-0.7-0.6-0.4-0.4-0.50.10.4
Distance moved, locomotor task time 20.40.52.10.00.11.40.20.30.10.80.3-0.3-0.01.0-1.4-0.8
Vertical activity count, locomotor time 20.40.63.50.20.31.90.30.40.10.5-0.1-0.3-0.01.4-0.8-0.8
Light reinforcement 10.81.99.3-1.8-1.2-3.1-1.3-0.9-1.1-1.0-0.3-0.9-1.5-1.1-1.10.5
Light reinforcement 20.10.21.2-0.40.0-1.1-0.10.1-0.00.30.40.0-0.2-0.7-0.20.4
Bone: marrow area0.10.30.8-0.3-0.4-0.2-0.5-0.6-0.5-0.5-0.5-0.5-0.90.8-0.3-0.1
Bone: maximum diameter0.10.30.7-0.6-0.3-0.7-0.4-0.8-0.5-0.3-0.0-0.3-0.80.2-0.6-0.1
Bone: maximum force1.32.23.8-1.9-1.6-0.6-1.4-1.9-1.9-1.6-1.0-1.7-1.71.2-1.2-1.1
Bone: maximum moment1.11.93.2-1.7-1.5-0.5-1.3-1.7-1.8-1.4-1.0-1.5-1.41.3-1.1-1.0
Mean time between licks in bursts0.20.63.3-0.2-0.51.4-0.4-0.6-0.6-0.5-0.8-0.60.21.8-0.2-0.5
Mean num. licks in bursts1.52.45.61.31.80.11.71.41.91.91.21.81.8-2.40.90.4
Cd content in liver0.20.21.10.1-0.40.3-0.6-0.6-0.2-0.7-1.0-0.4-0.10.20.1-0.6
Co content in liver0.30.31.20.40.1-0.60.20.70.60.30.10.40.4-0.50.91.1
Cu content in liver0.60.71.81.30.50.40.50.91.20.5-0.10.81.0-0.81.30.7
Fe content in liver0.30.40.9-0.0-0.41.0-0.6-0.6-0.4-0.6-0.8-0.6-0.60.5-0.7-0.8
K content in liver0.90.83.70.80.6-0.90.50.80.80.70.60.90.6-0.91.01.9
Mg content in liver1.11.26.10.50.3-2.10.10.30.80.70.40.80.3-0.91.02.5
Mn content in liver0.30.30.7-0.8-0.5-0.8-0.4-0.3-0.60.00.1-0.5-0.40.8-0.20.6
Na content in liver0.70.71.90.41.00.21.10.90.71.21.40.70.5-1.2-0.50.2
Rb content in liver0.10.10.70.3-0.2-0.8-0.2-0.30.3-0.00.10.1-0.2-0.50.30.3
Se content in liver2.22.64.72.01.6-0.11.41.62.21.91.11.91.8-1.51.51.6
Sr content in liver0.90.85.70.50.8-0.20.70.80.80.40.60.80.6-2.40.2-0.2
Zn content in liver3.64.06.32.52.20.21.92.12.42.31.62.32.0-0.81.82.5
Bone: minimum diameter0.00.00.20.2-0.00.50.0-0.1-0.0-0.2-0.1-0.1-0.10.30.10.2
Time in familiar zone, hab. session 10.20.21.4-0.00.1-0.30.20.50.10.40.40.1-0.00.5-0.11.2
Time in novel zone, hab. session 10.50.51.4-0.4-0.7-0.1-0.9-0.7-0.6-1.1-1.2-0.5-0.6-0.10.3-1.0
Total zone transitions, hab. session 10.30.53.2-0.8-0.2-1.8-0.1-0.1-0.3-0.20.40.0-0.4-0.80.11.2
Total locomotion distance, hab. session 10.91.23.70.40.9-1.60.80.60.90.91.31.10.5-1.60.71.9
Locomotion velocity, hab. session 11.31.94.60.71.2-1.61.10.81.21.21.61.40.8-2.01.02.1
Time in familiar zone, hab. session 20.20.20.60.40.40.70.40.60.60.50.00.30.40.30.0-0.4
Time in novel zone, hab. session 20.50.51.6-0.4-0.7-0.4-1.0-0.9-0.9-1.3-0.9-0.6-0.80.30.20.1
Total zone transitions, hab. session 20.30.41.4-0.5-0.6-1.2-0.7-0.5-0.4-0.8-0.7-0.3-0.5-0.20.30.1
Total locomotion distance, hab. session 20.30.41.40.50.5-1.20.10.10.6-0.00.20.70.2-0.61.00.7
Locomotion velocity, hab. session 20.20.31.70.30.3-1.30.0-0.10.4-0.10.10.50.1-0.70.80.6
Novel to familiar place preference ratio2.32.59.2-1.0-1.41.9-1.3-1.1-1.4-1.4-1.9-1.7-0.83.0-1.3-1.3
Novelty place preference2.32.59.3-0.8-1.22.1-1.2-1.1-1.3-1.3-2.0-1.6-0.63.1-1.2-1.4
Time in novel zone, NPP test2.32.59.1-0.8-1.31.9-1.4-1.0-1.4-1.4-2.1-1.6-0.73.0-1.0-1.3
Total zone transitions, NPP test0.81.15.8-0.9-0.9-2.4-1.0-1.0-0.9-1.2-0.5-0.4-1.4-0.20.31.0
Total locomotion distance, NPP test0.70.96.6-0.3-0.4-2.6-0.7-0.7-0.3-0.9-0.20.0-0.9-0.90.61.2
Locomotion velocity, NPP test0.50.74.9-0.1-0.0-2.2-0.3-0.50.0-0.30.30.3-0.7-1.10.21.3
Intraocular pressure2.43.45.4-2.3-2.3-1.5-2.2-1.8-2.1-2.1-2.3-1.9-1.61.0-0.7-1.4
Delta distance traveled before/after self-admin0.50.62.7-0.70.40.10.60.60.10.70.70.00.0-1.1-1.0-1.6
Delta ambulatory time before/after self-admin0.40.52.4-0.60.4-0.00.50.70.30.80.60.10.3-1.0-0.9-1.5
Parametrial fat weight0.10.21.80.20.11.30.30.40.20.4-0.2-0.00.70.4-0.4-0.4
Pavlov. Cond. lever latency0.10.21.10.60.11.00.10.30.2-0.1-0.10.00.30.50.1-0.3
Pavlov. Cond. magazine entry latency0.30.42.3-0.20.3-1.50.20.10.2-0.30.60.4-0.3-1.20.30.6
Pavlov. Cond. change in total contacts0.10.11.2-0.3-0.0-1.10.1-0.00.10.10.40.2-0.1-0.00.30.5
Pavlov. Cond. index score0.20.31.8-0.40.1-1.30.1-0.1-0.0-0.10.40.2-0.4-0.90.10.4
Pavlov. Cond. latency score0.20.31.7-0.30.1-1.30.1-0.00.0-0.00.40.2-0.3-0.90.20.6
Pavlov. Cond. lever contacts0.10.11.1-0.50.0-1.00.1-0.2-0.00.20.30.1-0.2-0.40.00.3
Pavlov. Cond. magazine entry number0.30.41.70.90.31.30.30.40.40.7-0.10.30.80.80.60.3
Pavlov. Cond. intertrial magazine entries0.30.41.00.0-0.70.8-0.7-0.6-0.3-0.5-1.0-0.6-0.11.0-0.2-0.4
Pavlov. Cond. lever-magazine prob. diff.0.20.21.7-0.6-0.1-1.3-0.0-0.3-0.2-0.30.20.0-0.4-0.60.00.3
Pavlov. Cond. response bias0.20.21.3-0.8-0.2-1.2-0.1-0.4-0.3-0.40.1-0.2-0.6-0.4-0.4-0.1
Pavlov. Cond. lever latency0.10.20.6-0.10.20.60.40.30.10.70.5-0.00.10.1-0.8-0.2
Pavlov. Cond. magazine entry latency0.40.51.0-0.4-0.8-0.2-0.8-0.8-0.6-0.8-0.6-0.7-0.80.6-0.5-1.0
Pavlov. Cond. change in total contacts0.20.31.60.4-0.3-0.3-0.4-0.00.2-0.5-0.90.10.00.31.3-0.2
Pavlov. Cond. index score0.20.30.7-0.1-0.5-0.5-0.7-0.6-0.3-0.9-0.7-0.3-0.40.20.4-0.3
Pavlov. Cond. latency score0.20.30.8-0.1-0.5-0.2-0.7-0.7-0.4-0.9-0.8-0.4-0.50.50.3-0.6
Pavlov. Cond. lever contacts0.10.20.90.2-0.1-0.6-0.3-0.20.1-0.5-0.40.20.0-0.30.90.4
Pavlov. Cond. magazine entry number0.70.91.80.41.0-0.01.21.10.81.31.40.80.9-1.10.00.9
Pavlov. Cond. intertrial magazine entries0.71.12.50.61.20.71.51.20.91.61.30.91.1-0.7-0.10.6
Pavlov. Cond. lever-magazine prob. diff.0.20.30.7-0.1-0.5-0.3-0.7-0.6-0.3-0.8-0.7-0.3-0.50.40.4-0.4
Pavlov. Cond. response bias0.20.31.0-0.2-0.5-1.0-0.7-0.5-0.3-0.9-0.6-0.2-0.6-0.10.50.1
Time in closed arm before self-admin1.41.85.41.51.80.51.71.11.31.42.31.30.5-1.50.00.0
Time in closed arm after self-admin0.80.91.70.91.30.31.20.80.91.01.31.10.6-1.10.4-0.5
Time in open arm before self-admin0.90.92.2-1.0-1.1-0.5-0.9-0.8-1.0-1.2-1.4-0.7-0.51.50.80.3
Time in open arm after self-admin1.21.32.2-1.2-1.3-1.1-1.5-1.1-1.2-1.1-1.1-1.4-1.50.8-0.90.4
Bone: periosteal estimation0.00.10.3-0.2-0.2-0.3-0.2-0.4-0.3-0.2-0.1-0.2-0.50.3-0.30.2
Bone: periosteal perimeter0.50.91.41.11.20.31.20.91.01.01.11.10.9-0.70.80.9
Bone: post-yield work0.40.61.5-0.7-0.7-1.2-0.8-0.7-0.8-1.0-0.2-0.6-1.20.5-0.10.4
Progressive ratio test 1 active lever presses0.50.61.61.11.0-0.10.60.90.80.21.10.4-0.60.10.51.3
Progressive ratio test 1 breakpoint0.40.51.30.90.9-0.30.40.70.70.11.10.3-0.80.00.41.1
Progressive ratio test 1 inactive lever presses1.21.84.11.81.70.11.31.31.51.01.71.2-0.1-1.00.62.0
Progressive ratio test 2 active lever presses0.91.13.50.91.2-0.41.11.31.00.91.90.9-0.0-0.80.41.4
Progressive ratio test 2 breakpoint1.01.13.60.91.2-0.41.11.31.00.91.90.9-0.0-0.80.41.4
Progressive ratio test 2 inactive lever presses1.01.73.31.31.4-0.11.41.51.51.41.81.20.5-1.20.61.7
Incentive Sensitization - Responses0.20.20.8-0.6-0.1-0.90.20.0-0.20.10.9-0.0-0.2-0.8-0.50.2
Incentive Sensitization - Breakpoint0.20.31.0-0.6-0.0-0.90.30.1-0.10.31.00.1-0.1-0.8-0.60.2
Sum of active levers in priming session hrs 5-60.30.31.1-0.1-0.40.9-0.3-0.2-0.3-0.1-0.4-0.50.11.0-0.4-1.0
Progressive ratio1.52.35.91.51.6-1.21.31.11.60.91.71.70.6-2.41.61.7
Food seeking constrained by brief footshock1.41.73.82.01.70.91.31.11.71.10.91.51.1-1.31.20.4
Seeking ratio, punishment vs. effort0.50.73.50.0-0.31.9-0.2-0.1-0.2-0.1-0.9-0.40.41.7-0.4-1.2
Retroperitoneal fat weight0.31.22.71.31.21.51.21.10.80.60.61.01.7-0.11.40.6
Reaction time number correct0.50.92.51.51.30.80.70.81.00.60.30.90.3-0.40.91.6
Reaction time mean minus median0.20.62.2-0.2-0.70.9-0.6-0.5-0.4-0.4-0.4-0.8-0.41.5-1.1-0.9
Reaction time mean minus median AUC0.30.82.7-0.2-0.81.4-0.6-0.5-0.6-0.7-0.5-1.0-0.31.6-1.1-0.8
Reaction time num false alarms0.71.04.60.1-1.00.9-1.2-0.7-0.5-1.1-2.1-0.70.21.60.8-0.3
Reaction time num false alarms AUC0.40.63.40.3-0.70.5-0.9-0.5-0.1-0.8-1.8-0.40.40.90.90.0
Reaction time trials correct on left0.50.92.51.51.30.80.70.81.00.60.30.90.3-0.40.91.6
Reaction time trials on left0.40.82.41.41.20.80.60.70.90.50.20.80.2-0.40.91.5
Reaction time mean0.40.62.6-0.5-0.90.5-0.7-0.5-0.7-0.8-0.8-0.9-0.21.6-0.3-0.6
Reaction time mean AUC0.20.31.9-0.1-0.50.7-0.4-0.2-0.4-0.4-0.5-0.50.11.4-0.1-0.4
Median of all reaction times0.50.72.2-0.8-1.00.2-0.8-0.6-0.9-1.0-0.9-1.0-0.31.5-0.2-0.5
Reaction time omissions0.20.30.9-0.5-0.8-0.6-0.7-0.5-0.5-0.9-0.7-0.6-0.20.1-0.10.1
Reaction time false alarm rate0.50.72.2-0.5-1.2-0.1-1.1-0.7-0.6-0.8-1.5-0.70.21.00.2-0.7
Reaction time premature initiation rate2.73.86.62.22.1-0.91.71.82.31.21.72.41.5-2.62.31.9
Reaction time premature initiations2.13.86.42.52.2-0.41.71.82.31.11.42.31.3-2.32.52.3
Std. dev. reaction times0.20.41.8-0.1-0.50.9-0.5-0.3-0.4-0.5-0.4-0.6-0.21.3-0.6-0.7
Reaction time trials completed0.40.82.41.41.20.80.60.70.90.50.20.80.2-0.40.91.5
Reaction time trials AUC0.40.72.31.31.10.60.60.60.80.50.30.80.1-0.40.71.5
Run reversals in cocaine runway, females0.10.10.40.50.70.60.50.30.10.20.40.40.00.10.3-0.2
Run reversals in cocaine runway, males0.00.00.30.10.00.4-0.00.2-0.0-0.2-0.2-0.00.00.50.10.1
Latency to leave start box in cocaine runway1.41.62.5-1.5-1.5-0.1-1.4-1.3-1.3-1.5-1.6-1.4-0.80.2-1.2-1.5
Latency to leave start box in cocaine runway, F0.70.81.3-1.1-1.1-0.2-0.9-0.8-1.0-1.0-1.0-1.0-0.60.3-0.8-1.0
Latency to leave start box in cocaine runway, M0.50.51.3-0.6-0.60.1-0.7-0.7-0.6-0.9-1.1-0.6-0.2-0.1-0.5-0.9
Std. dev. time between licks in bursts0.40.51.1-0.8-0.7-0.2-0.6-0.8-1.0-1.1-0.2-0.7-0.61.0-0.4-0.4
Total sessions with >9 infusions0.40.51.51.00.7-0.00.30.90.90.20.60.5-0.00.11.01.2
Short access day 1 total inactive lever presses0.91.13.90.51.2-0.80.90.71.11.51.61.00.4-2.0-0.40.6
Short access day 10 total inactive lever presses0.30.61.9-1.1-0.7-1.0-0.6-0.7-0.4-0.1-0.3-0.5-0.3-1.3-1.4-0.7
Short access day 1 total infusions0.10.10.40.1-0.1-0.1-0.50.10.0-0.3-0.2-0.4-0.60.50.00.5
Short access day 10 total infusions0.30.41.30.2-0.4-0.5-0.8-0.5-0.3-0.9-0.5-0.6-1.20.60.10.7
Short access total infusions0.10.10.60.50.30.2-0.10.40.3-0.10.0-0.1-0.40.40.30.8
Short access day 1 locomotion0.20.30.70.30.4-0.80.30.50.60.40.80.4-0.2-0.90.30.5
Short access day 10 total locomotion0.61.04.7-1.1-0.9-2.2-1.3-1.2-0.6-0.5-0.6-0.7-0.9-0.8-0.60.6
Short access total locomotion0.50.61.80.50.6-1.00.40.60.90.61.00.60.1-1.30.51.3
One hour access (0.3 mA shock)0.20.20.60.50.60.40.40.80.40.40.80.2-0.00.50.20.6
Compulsive drug intake0.20.31.8-0.7-0.20.5-0.10.0-0.40.2-0.6-0.30.61.3-0.1-0.5
One hour access (shock baseline)0.60.92.51.41.10.20.90.90.90.61.60.7-0.2-0.80.51.3
Social response proportion0.30.31.1-0.4-0.4-1.0-0.6-0.2-0.4-1.0-0.4-0.3-0.7-0.50.30.4
Social responses0.20.30.80.10.4-0.90.40.40.20.20.80.4-0.3-0.90.10.9
Social time0.10.10.40.40.4-0.20.30.40.20.10.60.3-0.2-0.4-0.00.6
Soleus weight0.82.511.7-1.6-1.4-3.4-1.6-1.6-1.3-1.5-0.9-0.8-1.90.20.11.1
Bone: stiffness0.71.12.3-1.1-1.00.1-0.9-1.2-1.2-1.1-0.9-1.1-0.91.0-0.6-1.5
Tibialis anterior weight5.719.229.7-5.2-4.9-5.3-5.0-5.1-4.8-4.8-3.5-4.2-5.40.9-3.4-1.5
Time to tail flick, vehicle, before self-admin0.80.81.91.41.11.31.00.91.00.50.60.90.8-0.50.7-0.0
Time to tail flick, vehicle, after self-admin1.21.62.61.61.40.01.31.41.51.61.31.50.9-0.41.01.4
Time to tail flick, test, before self-admin2.72.84.71.51.8-1.31.61.41.61.22.21.91.0-1.81.92.2
Time to tail flick, test, after self-admin3.13.27.51.91.8-0.81.41.62.01.11.22.11.4-1.32.62.7
Delta time to tail flick, vehicle, before/after SA0.20.21.10.30.1-0.50.10.30.50.6-0.00.40.50.20.61.0
Delta time to tail flick, test, before/after SA0.30.31.60.1-0.40.2-0.6-0.20.0-0.5-1.3-0.20.10.80.50.5
Tibia length3.59.816.02.83.50.73.83.33.44.03.93.43.3-3.61.11.6
Ambulatory time before self-admin0.10.10.3-0.3-0.2-0.40.0-0.0-0.50.00.6-0.1-0.2-0.2-0.5-0.1
Ambulatory time after self-admin0.60.72.4-0.60.4-0.40.70.90.10.91.10.30.3-1.5-0.9-1.6
Bone: tissue strength0.90.91.9-1.3-1.1-0.4-0.8-0.9-1.2-0.9-0.9-0.9-0.71.0-0.5-1.4
Total heroin consumption0.50.61.1-1.0-0.9-1.1-0.8-0.6-0.7-0.3-0.4-0.7-0.8-0.1-1.0-1.0
Bone: trabecular number3.04.97.3-2.5-2.6-0.7-2.4-2.7-2.5-2.1-1.7-2.5-2.31.7-2.5-1.8
Bone: trabecular spacing1.92.55.51.51.60.91.72.31.71.51.21.61.8-1.21.61.3
Bone: trabecular thickness2.22.85.9-1.8-2.0-0.9-1.8-2.4-2.0-1.8-1.4-1.8-1.61.4-1.4-1.0
Bone: trabecular tissue density0.00.10.30.00.3-0.00.30.20.00.20.60.10.0-0.4-0.3-0.1
Water consumed over 24 hours0.10.10.50.30.4-0.50.1-0.00.2-0.3-0.10.3-0.5-0.70.60.2
Number of responses in last shaping day2.52.75.02.21.70.71.71.81.90.91.51.91.3-1.12.21.6