Ltbp1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	PL	gene expression	Ltbp1	0.24	0.06	0.0e+00	0.2	0.27	0.27	0.25	2.4e-21	3.9e-29	1.0e-29	8.6e-27
2	Brain	gene expression	Ltbp1	0.53	0.1	0.0e+00	0.37	0.41	0.42	0.4	8.5e-36	9.9e-41	9.4e-43	3.9e-40
3	pVTA	gene expression	Ltbp1	0.25	0.1	1.4e-08	0.21	0.16	0.18	0.22	1.2e-09	2.2e-07	2.6e-08	9.3e-10
4	IL	gene expression	Ltbp1	0.32	0.12	1.1e-05	0.23	0.2	0.22	0.24	3.4e-06	1.9e-05	4.4e-06	2.3e-06
5	Liver	gene expression	Ltbp1	0.12	0.05	3.5e-14	0.07	0.09	0.09	0.04	5.0e-08	1.6e-10	1.6e-10	3.6e-05
6	Adipose	mRNA stability	Ltbp1	0.24	0.08	0.0e+00	0.15	0.18	0.17	0.17	3.8e-16	7.0e-20	9.2e-19	1.1e-18
7	OFC	gene expression	Ltbp1	0.2	0.1	3.8e-03	0.11	0.13	0.07	0.1	1.3e-03	6.0e-04	1.1e-02	2.3e-03
8	BLA	gene expression	Ltbp1	0.19	0.08	4.5e-10	0.1	0.17	0.16	0.16	4.0e-06	3.2e-09	4.1e-09	3.7e-09
9	LHb	gene expression	Ltbp1	0.41	0.13	6.6e-09	0.3	0.38	0.4	0.4	5.9e-08	6.6e-10	1.2e-10	1.2e-10
10	NAcc	gene expression	Ltbp1	0.09	0.04	3.0e-12	0.11	0.1	0.11	0.11	1.5e-12	3.3e-11	1.5e-12	2.2e-12
11	Adipose	gene expression	Ltbp1	0.21	0.07	0.0e+00	0.17	0.2	0.2	0.19	9.4e-19	3.1e-21	1.4e-21	1.6e-20

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6	7	8	9	10	11
Bone: apparent density	4.6	7.7	10.5	3.0	3.2	-2.9	-2.9	3.0	-0.5	-2.7	-2.9	-2.6	2.8	3.1
Area under the delay curve	0.2	0.2	0.6	-0.8	-0.1	0.4	0.4	-0.6	-0.1	0.2	0.3	0.2	-0.5	-0.5
BMI with tail	2.2	7.2	13.0	3.6	2.9	-2.9	-2.9	2.7	-3.0	-2.4	-2.7	-2.3	2.0	1.4
BMI without tail	1.2	2.4	8.0	1.4	1.3	-1.7	-1.7	1.4	-2.8	-1.8	-1.3	-1.2	0.5	0.5
Body weight	0.2	0.8	4.4	1.4	0.7	-0.5	-0.8	0.8	-2.1	-0.2	-0.5	-0.4	0.2	-0.7
Weight adjusted by age	1.9	2.1	5.2	2.3	1.4	-1.5	-1.6	1.1	1.0	-1.1	-1.1	-0.5	1.3	2.2
Bone surface	1.0	1.8	2.8	1.5	1.5	-1.3	-1.4	1.6	0.4	-1.2	-1.4	-1.1	1.5	1.7
Bone volume	1.5	2.6	3.7	1.9	1.9	-1.6	-1.7	1.7	0.1	-1.5	-1.6	-1.3	1.6	1.9
Breakpoint value in progressive ratio session	1.2	1.3	2.4	0.6	1.3	-1.2	-1.4	1.1	-0.5	-1.4	-1.3	-1.1	0.9	1.6
Number of licking bursts	0.3	0.3	1.0	0.5	0.1	-0.5	-0.3	0.6	0.2	-0.3	-0.7	-1.0	0.8	0.4
Context. condit. distance diff. score	0.9	1.1	1.7	-0.3	-1.2	1.2	1.2	-0.9	0.8	1.3	1.2	1.3	-0.9	-1.0
Locomotion velocity, session 1	2.1	2.2	3.1	1.1	1.6	-1.7	-1.6	1.6	-1.5	-1.5	-1.6	-1.8	1.3	0.8
Locomotion distance, session 1	1.6	2.1	5.8	0.3	1.0	-1.7	-1.8	1.4	-2.4	-1.7	-1.4	-1.5	0.7	0.6
Locomotion velocity, session 2	0.4	0.5	1.4	-0.1	0.8	-0.8	-0.6	0.8	-1.2	-0.5	-0.8	-0.9	0.4	-0.1
Locomotion distance, session 2	1.4	1.9	3.1	0.7	1.4	-1.6	-1.6	1.7	-1.8	-1.5	-1.5	-1.4	1.0	0.6
Locomotion velocity, session 3	1.4	1.7	2.7	1.1	1.2	-1.5	-1.5	1.2	-1.5	-1.6	-1.2	-1.1	0.8	1.3
Locomotion distance, session 3	4.0	4.4	6.1	1.3	2.3	-2.5	-2.2	2.2	-2.4	-2.3	-2.1	-2.2	1.5	1.5
Stereotopy head waving bouts, day 3	0.0	0.0	0.1	0.0	-0.3	0.0	0.0	0.1	0.3	0.2	-0.0	0.2	0.2	0.1
Stereotopy head waving duration, day 3	0.7	0.8	1.4	-0.6	-1.2	1.0	1.0	-0.8	0.8	1.0	0.9	0.9	-0.5	-0.7
Locomotion velocity, session 7	6.2	6.7	9.6	2.4	2.8	-3.1	-2.9	2.7	-2.6	-2.7	-2.7	-2.6	2.1	1.9
Locomotion distance, session 7	2.6	3.2	5.3	1.8	2.3	-2.0	-1.7	2.1	-1.4	-1.5	-1.9	-2.1	1.7	0.9
Stereotopy head waving bouts, day 7	0.2	0.2	1.0	0.3	-0.2	0.4	0.3	-0.5	1.0	0.5	0.3	0.6	-0.1	0.2
Stereotopy head waving duration, day 7	0.1	0.1	0.6	0.7	-0.0	0.2	0.1	-0.0	0.8	0.4	-0.0	0.2	0.3	0.2
Locomotion velocity, session 8	3.8	4.6	6.3	2.0	2.3	-2.4	-2.3	2.5	-1.9	-2.0	-2.3	-2.2	2.0	1.4
Locomotion distance, session 8	0.2	0.3	0.9	0.7	0.6	-0.6	-0.6	0.9	-0.8	-0.3	-0.6	-0.4	0.5	-0.1
Degree of sensitization distance	0.4	0.4	1.7	0.1	-0.3	0.7	0.6	-0.3	1.3	0.9	0.3	0.2	0.2	-0.5
Degree of sensitization stereotypy	0.2	0.2	0.4	0.1	-0.4	0.5	0.5	-0.6	0.5	0.7	0.5	0.6	-0.3	-0.4
Conditioned locomotion	1.5	1.7	3.5	1.9	1.3	-1.4	-1.3	1.4	-0.6	-1.2	-1.4	-1.1	1.2	1.1
Cocaine response after cond. corrected	1.5	1.7	2.5	0.9	1.5	-1.3	-1.3	1.6	-0.7	-1.3	-1.5	-1.5	1.4	1.2
Cocaine response after cond. not corrected	0.7	0.7	1.1	0.3	0.9	-0.9	-0.9	1.0	-0.8	-1.1	-0.9	-0.9	0.7	0.8
Cocaine response before conditioning	2.3	2.8	4.8	-2.2	-2.0	1.5	1.6	-1.8	-0.0	1.0	1.9	1.9	-2.1	-1.3
Saline control response	0.3	0.4	1.8	-1.3	-0.4	-0.1	0.1	-0.6	-0.9	-0.5	0.5	0.5	-0.9	0.2
Bone: connectivity density	4.9	7.6	9.7	2.8	3.0	-3.0	-2.9	3.1	-0.5	-2.7	-2.9	-2.5	2.8	3.1
Bone: cortical apparent density	0.2	0.2	0.8	0.0	0.4	-0.7	-0.3	0.1	-0.6	-0.9	-0.3	-0.4	0.0	0.5
Bone: cortical area	0.0	0.0	0.1	0.2	0.2	0.1	-0.3	-0.1	-0.2	-0.2	0.1	0.0	-0.3	0.3
Bone: cortical porosity	0.2	0.3	0.6	-0.0	-0.0	0.6	0.6	-0.4	0.8	0.8	0.4	0.3	-0.2	-0.6
Bone: cortical porosity	0.1	0.1	0.3	0.1	0.1	0.5	0.3	-0.3	0.6	0.6	0.2	0.2	-0.1	-0.5
Bone: cortical thickness	0.0	0.1	0.3	0.2	0.2	0.2	-0.1	-0.4	-0.2	-0.1	0.3	0.1	-0.6	0.1
Bone: cortical thickness	0.5	0.6	1.2	0.5	1.0	-0.8	-0.9	0.7	-1.1	-1.0	-0.8	-0.9	0.2	0.5
Bone: cortical tissue density	0.1	0.2	0.7	-0.0	0.4	-0.6	-0.2	0.1	-0.4	-0.8	-0.2	-0.3	0.0	0.5
Condit. Reinf. active minus inactive responses	1.3	1.5	3.6	0.9	1.2	-1.4	-1.3	1.0	-1.9	-1.3	-1.1	-1.3	0.7	0.5
Condit. Reinf. active-inactive response ratio	1.3	1.4	1.9	0.9	1.2	-1.3	-1.2	1.1	-0.8	-1.3	-1.3	-1.4	1.1	1.1
Condit. Reinf. active responses	1.4	1.7	3.8	1.3	1.2	-1.6	-1.4	1.3	-1.9	-1.4	-1.3	-1.3	0.9	0.6
Condit. Reinf. inactive responses	0.1	0.1	0.5	0.7	0.0	-0.3	-0.2	0.5	-0.2	-0.0	-0.3	-0.1	0.5	-0.0
Incentive salience index mean	1.0	1.2	3.1	0.8	1.0	-1.2	-1.2	1.0	-1.8	-1.2	-1.0	-1.1	0.6	0.4
Condit. Reinf. lever presses	0.1	0.1	0.5	0.4	0.4	-0.4	-0.4	0.3	-0.7	-0.2	-0.2	-0.1	0.0	-0.1
Condit. Reinf. active minus inactive responses	0.2	0.2	1.5	-0.2	0.2	-0.4	-0.3	0.2	-1.2	-0.4	-0.3	-0.4	0.0	-0.3
Condit. Reinf. active-inactive response ratio	0.4	0.4	0.9	-0.4	-0.7	0.6	0.6	-0.6	-0.5	0.5	0.7	0.6	-0.7	-1.0
Condit. Reinf. active responses	0.3	0.4	1.6	-1.2	-0.3	-0.0	-0.1	-0.4	-1.3	-0.4	0.3	0.1	-0.8	-0.4
Condit. Reinf. inactive responses	0.3	0.3	1.2	-0.9	0.2	-0.6	-0.6	0.0	-1.1	-0.8	-0.2	-0.2	-0.4	0.2
Condit. Reinf. lever presses	0.3	0.4	2.8	-0.1	0.0	-0.4	-0.5	0.3	-1.7	-0.5	-0.3	-0.5	-0.2	-0.4
Condit. Reinf. lever reinforcers received	0.3	0.4	2.5	-0.9	-0.0	-0.4	-0.5	-0.1	-1.6	-0.8	-0.1	-0.4	-0.4	-0.1
Conditioned reinforcement - actives	0.4	0.4	1.0	-1.0	0.2	-0.1	-0.2	-0.8	0.0	-0.9	0.3	0.3	-0.8	1.0
Conditioned reinforcement - inactives	0.6	0.7	2.2	-1.5	-0.1	-0.2	-0.3	-0.9	-1.0	-0.9	0.5	0.4	-1.2	0.4
Conditioned locomotion	1.0	1.3	3.7	-1.9	-0.7	-0.1	-0.1	-1.1	-1.4	-1.0	0.9	1.2	-1.8	0.3
Patch foraging indifference point 0 sec	0.8	1.3	3.2	0.9	1.6	-1.3	-1.1	1.0	-0.7	-0.8	-1.3	-1.8	0.9	0.8
Patch foraging indifference point AUC	0.7	0.8	2.0	0.5	0.6	-1.1	-1.0	0.6	-0.5	-1.3	-0.8	-0.6	0.6	1.4
Delay disc. indifference point, 0s delay	1.6	1.7	2.8	-1.0	-0.8	1.3	1.6	-1.7	0.9	1.4	1.5	1.5	-1.2	-1.4
Delay disc. indifference point, 16s delay	0.0	0.0	0.1	0.0	0.2	-0.1	-0.1	0.1	-0.2	-0.2	-0.1	-0.2	-0.2	0.0
Delay disc. indifference point, 2s delay	0.3	0.3	0.9	-1.0	0.0	0.5	0.4	-0.9	0.1	0.1	0.5	0.5	-0.7	-0.3
Delay disc. indifference point, 24s delay	0.1	0.1	0.3	-0.2	0.1	-0.1	-0.2	0.1	-0.6	-0.3	-0.2	-0.2	-0.1	0.0
Delay disc. indifference point, 4s delay	0.6	0.7	1.4	-1.2	-0.7	0.8	1.0	-0.9	0.9	0.7	0.7	0.6	-0.6	-0.4
Delay disc. indifference point, 8s delay	0.1	0.1	0.6	-0.3	0.3	-0.3	-0.0	0.0	-0.8	-0.2	-0.3	-0.4	0.0	-0.4
Indifference point function ln k	0.3	0.4	1.7	-0.1	-0.3	0.9	0.8	-0.1	1.3	1.1	0.3	0.0	0.2	-0.5
Indifference point function log k	0.3	0.4	1.7	-0.1	-0.3	0.9	0.8	-0.1	1.3	1.1	0.3	0.0	0.2	-0.5
Patch foraging total patch changes 0 sec	0.9	1.4	3.3	1.0	1.6	-1.4	-1.1	1.1	-0.9	-0.8	-1.3	-1.8	1.0	0.7
Patch foraging total patch changes 12 sec	1.0	1.2	2.0	1.3	1.3	-1.2	-1.2	1.0	-0.6	-0.9	-1.2	-1.4	0.9	0.9
Patch foraging total patch changes 18 sec	1.5	2.0	3.5	0.8	1.4	-1.7	-1.7	1.0	-1.3	-1.9	-1.4	-1.4	0.8	1.7
Patch foraging total patch changes 24 sec	0.1	0.1	0.2	0.3	0.0	0.4	0.1	-0.4	0.2	0.3	0.2	0.2	-0.1	-0.1
Patch foraging total patch changes 6 sec	0.4	0.6	1.2	0.5	1.0	-0.8	-0.5	0.6	0.5	-0.4	-0.8	-1.1	1.0	0.8
Patch foraging time to switch 0 sec	1.3	2.0	3.5	1.6	1.4	-1.7	-1.6	1.4	-1.9	-1.6	-1.3	-1.0	0.6	0.8
Patch foraging water rate 0 sec	0.8	1.3	2.2	-1.4	-1.5	1.4	1.3	-1.2	1.3	1.4	1.0	0.5	-0.5	-0.7
Patch foraging water rate 12 sec	3.5	5.3	8.0	-1.4	-2.5	2.8	2.7	-2.2	1.1	2.8	2.4	2.3	-1.9	-2.7
Patch foraging water rate 18 sec	4.4	5.9	9.7	-2.4	-3.1	2.9	2.6	-2.6	1.5	2.5	2.5	2.1	-1.9	-2.1
Patch foraging water rate 24 sec	1.3	1.8	4.0	-0.0	-1.8	1.7	1.6	-0.9	1.1	2.0	1.2	0.9	-0.6	-1.6
Patch foraging water rate 6 sec	1.6	2.4	4.3	-0.3	-1.8	1.9	1.7	-1.3	0.9	2.1	1.6	1.5	-1.0	-1.9
Seeking ratio, delayed vs. immediate footshock	0.5	0.6	1.8	-0.5	-1.0	0.4	0.1	-0.5	-1.0	-0.0	1.0	1.1	-1.3	-0.5
Distance traveled before self-admin	0.2	0.2	0.6	0.5	-0.7	-0.0	-0.1	-0.4	-0.3	-0.1	0.4	0.8	-0.7	0.1
Distance traveled after self-admin	0.1	0.1	0.3	-0.5	-0.1	-0.2	-0.2	-0.5	-0.6	-0.1	0.2	0.4	-0.5	0.0
Extensor digitorum longus weight	3.5	13.9	21.5	2.7	3.6	-4.6	-4.5	3.5	-4.3	-4.6	-3.7	-3.2	2.3	3.2
Bone: elastic displacement	0.0	0.1	0.2	0.1	-0.2	0.1	0.2	0.0	0.5	0.3	-0.0	-0.2	0.3	0.0
Bone: elastic work	0.3	0.4	1.3	1.1	0.8	-0.6	-0.6	0.7	-0.6	-0.3	-0.6	-0.4	0.4	0.1
Bone: endosteal estimation	0.1	0.2	0.4	0.4	0.3	-0.4	-0.5	0.6	0.1	-0.3	-0.4	-0.2	0.5	0.4
Bone: endosteal perimeter	0.4	0.9	1.8	-0.8	-1.3	1.1	0.9	-0.8	0.9	0.8	1.1	1.2	-0.7	-0.5
Epididymis fat weight	0.5	1.2	5.4	0.3	-0.3	1.2	1.2	-0.6	2.3	1.7	0.8	0.6	0.2	-0.4
Delta time in closed arm before/after self-admin	1.1	1.1	2.3	1.3	1.5	-0.8	-0.6	1.2	0.6	-0.1	-1.1	-1.1	1.5	0.3
Delta time in open arm before/after self-admin	0.4	0.4	1.7	-0.3	-0.3	-0.4	-0.6	-0.1	-1.3	-1.1	-0.2	-0.1	-0.4	0.7
Diff in mean of infusions in LGA sessions	1.4	1.5	5.6	0.8	1.3	-1.0	-1.3	0.8	0.5	-1.5	-1.1	-0.9	0.9	2.4
Delay discount exponential model param	0.1	0.1	0.3	0.5	-0.1	-0.1	-0.2	0.3	0.2	0.0	0.0	0.2	0.2	0.3
Extinction: sum of active levers before priming	0.2	0.2	0.8	0.9	0.5	0.4	0.2	0.4	0.7	0.6	-0.2	-0.3	0.5	-0.2
Active lever presses in extinction session 6	2.3	2.2	4.4	-2.1	-1.1	1.4	1.3	-2.0	1.1	0.9	1.8	1.7	-1.8	-0.2
Bone: final force	0.8	1.4	2.6	1.1	1.6	-1.1	-1.4	1.1	-0.5	-1.2	-1.1	-1.2	0.8	1.3
Bone: final moment	0.8	1.3	2.7	1.1	1.7	-1.1	-1.4	1.1	-0.4	-1.2	-1.1	-1.1	0.8	1.3
Food consumed during 24 hour testing period	0.5	0.6	2.1	-0.7	-0.9	1.0	0.9	-0.4	1.4	1.0	0.6	0.4	0.0	-0.3
Glucose	0.4	0.6	1.5	-0.7	-1.1	1.1	0.9	-0.5	1.2	1.0	0.5	-0.0	0.2	-0.2
Heart weight	1.6	2.3	4.1	-1.1	-1.5	1.6	1.5	-1.6	0.1	1.6	1.6	1.5	-1.6	-2.0
Delay discount hyperbolic model param	0.1	0.1	0.4	0.7	-0.1	-0.1	-0.2	0.4	0.2	0.0	-0.1	0.0	0.3	0.3
Intermittent access intake day 1-15 change	0.6	0.6	1.2	0.1	-1.1	0.8	0.6	-0.7	-0.0	0.9	0.9	1.1	-0.9	-0.9
Intermittent access intake escalation	0.5	0.5	1.1	0.4	-0.9	0.7	0.6	-0.5	0.3	0.9	0.8	1.1	-0.7	-0.6
Intermittent access intake escalation 2	0.5	0.5	1.0	0.3	-0.7	0.7	0.6	-0.7	0.7	0.8	0.8	1.0	-0.6	-0.5
Intermitt. access day 1 inactive lever presses	0.8	0.9	2.8	-0.6	0.0	-0.2	-0.1	-0.8	-1.7	-0.2	0.9	1.2	-1.7	-0.9
Intermitt. access day 15 inactive lever presses	0.4	0.5	1.6	-0.6	-0.1	0.1	-0.1	-0.9	-0.1	-0.4	0.8	1.3	-1.2	0.3
Intermitt. access escalation Index	0.4	0.4	1.9	1.4	0.5	-0.4	-0.2	-0.1	-0.2	-0.1	0.4	1.1	-0.6	-0.0
Intermittent access day 1 total infusions	0.6	0.7	2.4	-1.6	0.2	-0.8	-0.5	0.1	-0.8	-1.3	-0.6	-0.8	0.1	0.6
Intermittent access day 15 total infusions	0.3	0.3	1.2	-1.1	-0.9	0.1	0.2	-0.5	-0.6	-0.2	0.3	0.3	-0.7	-0.3
Intermittent access terminal intake (last 3 days)	0.4	0.5	2.2	-1.5	-0.8	0.1	0.3	-0.8	-0.5	-0.3	0.4	0.4	-0.8	-0.2
Intermittent access total infusions	0.7	0.8	5.6	-2.4	-1.0	0.2	0.5	-1.0	-0.5	-0.3	0.4	0.1	-0.8	-0.2
Intermittent access day 1 locomotion	1.0	1.0	3.8	-1.8	0.0	-1.0	-0.6	-0.1	-1.9	-1.4	-0.3	-0.5	-0.5	0.1
Intermittent access day 15 total locomotion	0.5	0.6	2.8	-0.6	-0.3	-0.7	-0.7	-0.1	-1.7	-1.3	-0.1	0.1	-0.6	0.4
Intermittent access total locomotion	0.6	0.7	3.0	-1.4	-0.4	-0.6	-0.4	-0.4	-1.7	-1.1	0.1	0.1	-0.8	-0.0
Intermittent access standard deviation	2.1	2.2	3.6	-1.3	-1.5	1.4	1.3	-1.7	0.1	1.3	1.7	1.9	-1.8	-1.5
Left kidney weight	1.1	3.0	5.6	-1.4	-1.7	1.8	1.5	-2.2	1.8	1.3	2.1	2.4	-1.8	-0.3
Right kidney weight	1.3	3.7	6.2	-1.2	-1.9	2.2	1.7	-2.3	1.2	1.8	2.3	2.5	-2.1	-1.2
Cocaine induced anxiety	1.7	1.9	4.0	2.0	1.7	-1.6	-1.7	1.4	-0.9	-1.5	-1.2	-0.7	0.8	1.3
Post-drug Anxiety	1.1	1.2	2.6	1.6	1.5	-1.3	-1.4	0.9	-0.2	-1.2	-0.9	-0.1	0.6	1.3
Baseline Anxiety	0.3	0.3	0.5	-0.6	-0.6	0.7	0.7	-0.6	0.6	0.7	0.5	0.5	-0.2	-0.6
Tail length	2.0	6.0	9.2	-3.0	-2.9	2.6	2.4	-2.6	0.7	1.9	2.7	2.3	-2.6	-2.2
Length with tail	1.3	4.9	6.2	-2.4	-2.2	2.5	2.2	-2.2	0.6	2.3	2.5	2.1	-2.3	-2.4
Length without tail	0.1	0.3	0.9	0.1	-0.2	0.6	0.5	-0.4	0.4	0.9	0.5	0.6	-0.3	-0.7
Times rat made contact with spout	1.7	1.9	2.5	-1.6	-1.5	1.6	1.6	-1.2	0.3	1.5	1.5	1.1	-1.3	-1.6
Lifetime Intake	0.5	0.6	4.7	-2.2	-0.7	-0.0	0.3	-0.7	-0.6	-0.5	0.1	-0.2	-0.5	-0.1
Liver weight, left	1.0	1.5	2.6	-1.6	-1.3	1.2	1.3	-1.6	0.4	0.8	1.4	1.2	-1.5	-0.7
Liver weight, right	4.7	7.8	9.9	-2.7	-2.8	3.1	3.1	-3.1	1.8	3.1	2.9	2.5	-2.3	-2.8
Locomotor activity	1.0	1.6	3.2	0.8	1.8	-1.5	-1.6	1.1	-1.5	-1.4	-1.3	-1.2	0.7	0.7
Locomotor testing distance	1.7	2.9	4.3	1.4	2.0	-2.0	-2.1	1.8	-1.9	-1.9	-1.7	-1.5	1.0	1.1
Locomotor testing rearing	0.5	0.8	4.1	-0.6	0.4	-0.9	-0.9	0.8	-2.0	-1.0	-0.7	-0.9	0.0	-0.2
Locomotion in novel chamber	0.4	0.5	1.2	-0.9	-0.6	0.4	0.3	-0.7	-0.7	0.2	0.8	1.1	-1.1	-0.7
Locomotion in novel chamber post-restriction	1.6	1.9	2.9	-1.5	-1.1	1.5	1.2	-1.6	-0.4	1.1	1.5	1.4	-1.7	-1.6
Fecal boli incidents, locomotor time 1	0.3	0.3	1.3	1.1	0.5	0.0	-0.1	0.6	0.6	0.4	-0.4	-0.5	0.8	-0.2
Change in fecal boli incidents, locomotor task	3.1	2.9	4.6	-2.1	-2.1	1.8	2.0	-1.4	0.3	1.7	1.7	1.4	-1.5	-1.9
Time >=10cm from walls, locomotor time 1	0.8	0.8	2.2	0.4	-1.0	1.0	1.0	0.4	0.6	1.5	0.1	-0.3	0.5	-1.5
Bouts of movement, locomotor time 1	0.2	0.3	1.4	0.6	0.3	0.1	0.1	0.5	-0.7	0.4	-0.1	0.0	0.2	-1.2
Total resting periods, locomotor time 1	0.3	0.3	2.0	0.5	0.0	0.4	0.5	0.4	-0.2	0.8	0.0	0.0	0.3	-1.4
Rest time, locomotor task time 1	0.3	0.4	2.0	0.4	0.1	0.3	0.6	0.2	0.3	1.0	0.1	0.1	0.4	-1.4
Distance moved, locomotor task time 1	0.2	0.2	1.4	-0.1	-0.0	-0.2	-0.2	0.1	0.8	-0.5	-0.2	-0.1	0.1	1.2
Vertical activity count, locomotor time 1	0.1	0.1	0.3	-0.6	-0.3	0.3	0.2	-0.4	0.1	-0.1	0.3	0.3	-0.5	0.3
Time >=10cm from walls, locomotor time 2	0.9	0.9	2.9	-0.5	-1.3	1.2	1.2	-0.1	1.7	1.3	0.2	-0.3	0.5	-0.8
Bouts of movement, locomotor time 2	2.2	2.4	5.7	-0.8	-1.3	1.7	2.0	-1.0	1.0	2.3	1.4	1.1	-0.6	-2.4
Total resting periods, locomotor time 2	1.5	1.6	4.5	-0.5	-1.0	1.4	1.7	-0.7	0.9	2.0	1.1	0.8	-0.3	-2.1
Rest time, locomotor task time 2	0.7	0.9	2.7	0.8	0.9	-1.1	-0.9	1.1	-1.6	-0.8	-0.8	-0.6	0.4	-0.0
Distance moved, locomotor task time 2	0.3	0.3	2.0	-0.3	0.0	0.0	0.2	-0.6	1.4	-0.2	0.2	0.4	-0.0	0.9
Vertical activity count, locomotor time 2	0.4	0.4	3.0	-0.4	-0.1	0.4	0.5	-0.7	1.7	0.3	0.4	0.3	0.1	0.4
Light reinforcement 1	1.8	3.3	9.1	0.6	1.7	-2.3	-2.4	1.1	-3.0	-2.5	-1.5	-1.3	0.3	1.4
Light reinforcement 2	0.2	0.3	1.1	0.2	0.5	-0.5	-0.6	-0.0	-1.1	-0.7	-0.2	-0.0	-0.4	0.2
Bone: marrow area	0.1	0.1	0.4	0.3	0.3	-0.4	-0.5	0.6	-0.0	-0.3	-0.4	-0.2	0.4	0.4
Bone: maximum diameter	0.2	0.3	0.8	0.4	0.5	-0.5	-0.9	0.4	-0.5	-0.8	-0.3	-0.2	0.2	0.7
Bone: maximum force	1.2	2.1	3.8	1.7	2.0	-1.3	-1.6	1.5	-0.3	-1.3	-1.4	-1.5	1.2	1.5
Bone: maximum moment	1.1	1.9	3.6	1.7	1.9	-1.3	-1.5	1.4	-0.2	-1.2	-1.3	-1.3	1.2	1.4
Mean time between licks in bursts	0.3	0.4	1.6	0.9	0.4	-0.1	-0.2	0.7	1.3	0.3	-0.4	-0.2	0.9	0.6
Mean num. licks in bursts	1.6	1.9	3.3	-1.4	-1.1	1.5	1.3	-1.4	0.1	1.2	1.7	1.8	-1.7	-1.3
Cd content in liver	0.2	0.2	0.3	-0.4	-0.2	0.5	0.5	-0.4	0.3	0.5	0.4	0.3	-0.5	-0.6
Co content in liver	1.0	1.1	2.0	-1.4	-1.1	0.9	1.1	-0.9	-0.4	0.7	1.0	1.0	-1.3	-1.4
Cu content in liver	0.1	0.2	0.4	-0.5	-0.6	0.6	0.6	-0.1	0.1	0.5	0.2	-0.1	-0.1	-0.5
Fe content in liver	0.3	0.3	2.3	-0.1	-0.6	0.5	0.5	-0.3	1.5	0.5	0.3	0.2	0.2	0.3
K content in liver	0.6	0.5	1.1	-0.4	-1.0	0.5	0.5	-0.6	-0.5	0.6	0.8	0.9	-1.1	-0.9
Mg content in liver	0.6	0.6	3.2	-0.4	-0.6	-0.1	-0.1	-0.3	-1.8	-0.2	0.5	0.9	-1.1	-0.8
Mn content in liver	0.3	0.4	2.1	0.4	0.4	-0.4	-0.4	0.1	-1.5	-0.3	0.1	0.5	-0.8	-0.7
Na content in liver	0.9	1.0	2.2	-0.8	-1.1	0.9	0.7	-1.5	0.7	0.3	1.2	1.3	-1.2	0.1
Rb content in liver	0.3	0.4	1.1	-1.0	-0.8	0.1	0.3	-0.5	-1.1	-0.1	0.5	0.6	-0.8	-0.6
Se content in liver	1.7	2.1	3.4	-1.4	-1.9	1.4	1.5	-1.2	0.1	1.4	1.6	1.6	-1.6	-1.6
Sr content in liver	0.2	0.2	0.5	-0.2	-0.5	0.5	0.3	-0.4	-0.4	0.2	0.6	0.4	-0.7	-0.2
Zn content in liver	3.5	3.8	7.0	-2.3	-2.7	1.8	2.1	-1.8	0.7	1.6	2.1	2.0	-2.0	-1.8
Bone: minimum diameter	0.0	0.1	0.4	-0.1	-0.3	0.4	0.2	-0.1	0.6	0.3	0.1	-0.2	0.2	0.0
Time in familiar zone, hab. session 1	0.1	0.1	0.3	-0.4	-0.1	-0.2	-0.0	-0.3	-0.3	-0.3	0.2	0.5	-0.5	-0.1
Time in novel zone, hab. session 1	0.5	0.5	1.3	1.0	0.6	-0.4	-0.4	0.9	-0.1	0.0	-0.8	-1.1	1.1	0.1
Total zone transitions, hab. session 1	0.3	0.4	3.2	0.0	0.2	-0.6	-0.7	0.0	-1.8	-0.7	-0.1	-0.1	-0.5	-0.2
Total locomotion distance, hab. session 1	0.6	0.8	2.6	-0.9	-0.9	0.3	0.1	-0.7	-1.6	-0.0	0.8	0.8	-1.4	-0.8
Locomotion velocity, hab. session 1	0.9	1.3	2.8	-1.2	-1.3	0.7	0.4	-1.0	-1.6	0.2	1.1	1.1	-1.7	-1.1
Time in familiar zone, hab. session 2	0.2	0.2	0.6	-0.4	-0.2	0.5	0.7	-0.5	0.8	0.4	0.3	0.3	-0.2	-0.3
Time in novel zone, hab. session 2	0.6	0.6	1.2	0.8	0.4	-0.6	-0.8	1.0	-0.4	-0.3	-0.9	-1.1	1.1	0.5
Total zone transitions, hab. session 2	0.3	0.4	1.4	0.4	0.5	-0.6	-0.6	0.6	-1.2	-0.5	-0.6	-0.8	0.5	-0.1
Total locomotion distance, hab. session 2	0.2	0.2	1.6	-0.5	-0.5	0.1	0.1	0.0	-1.3	0.1	0.2	0.0	-0.4	-0.7
Locomotion velocity, hab. session 2	0.2	0.2	1.9	-0.4	-0.3	-0.1	-0.1	0.2	-1.4	-0.1	0.0	-0.1	-0.3	-0.5
Novel to familiar place preference ratio	1.9	2.0	4.4	2.0	1.4	-0.6	-0.9	1.2	1.9	-0.3	-1.3	-1.1	2.1	1.5
Novelty place preference	2.0	2.0	4.8	2.0	1.3	-0.5	-0.7	1.2	2.2	-0.1	-1.2	-1.1	2.1	1.5
Time in novel zone, NPP test	2.0	2.1	4.9	2.1	1.4	-0.6	-0.8	1.3	2.0	-0.1	-1.3	-1.2	2.2	1.4
Total zone transitions, NPP test	1.0	1.4	5.9	0.6	0.7	-1.3	-1.4	1.1	-2.4	-1.3	-1.0	-1.1	0.4	0.3
Total locomotion distance, NPP test	0.8	1.1	7.1	-0.0	0.3	-0.9	-1.2	0.8	-2.7	-1.1	-0.7	-0.8	0.0	0.1
Locomotion velocity, NPP test	0.5	0.8	5.4	-0.5	-0.0	-0.6	-0.9	0.4	-2.3	-1.0	-0.3	-0.3	-0.4	0.2
Intraocular pressure	2.5	3.4	5.8	1.4	2.4	-2.0	-2.0	2.1	-1.5	-1.5	-2.1	-2.1	1.9	0.9
Delta distance traveled before/after self-admin	0.1	0.1	1.1	-1.0	0.4	-0.0	-0.2	-0.3	-0.1	-0.2	0.0	-0.0	-0.2	0.3
Delta ambulatory time before/after self-admin	0.2	0.2	1.5	-1.2	0.3	0.1	0.0	-0.6	-0.2	-0.0	0.3	0.4	-0.5	0.1
Parametrial fat weight	0.2	0.5	1.1	-0.9	-0.3	0.8	0.7	-1.1	0.9	0.7	0.5	0.2	-0.2	-0.5
Pavlov. Cond. lever latency	0.2	0.3	1.8	0.2	-0.4	0.4	0.6	0.1	1.3	0.6	-0.0	-0.3	0.6	0.2
Pavlov. Cond. magazine entry latency	0.2	0.3	2.2	-0.3	0.2	-0.3	-0.5	-0.3	-1.5	-0.6	-0.0	-0.2	-0.5	-0.0
Pavlov. Cond. change in total contacts	0.2	0.2	1.3	-0.1	0.3	-0.3	-0.2	-0.0	-1.1	-0.4	0.0	0.1	-0.4	-0.3
Pavlov. Cond. index score	0.3	0.3	2.2	-0.2	0.5	-0.4	-0.6	-0.1	-1.5	-0.6	-0.1	-0.1	-0.5	-0.1
Pavlov. Cond. latency score	0.2	0.3	2.0	-0.3	0.4	-0.3	-0.5	-0.2	-1.4	-0.6	-0.0	-0.1	-0.5	-0.2
Pavlov. Cond. lever contacts	0.2	0.2	0.9	-0.0	0.6	-0.4	-0.5	-0.0	-1.0	-0.5	-0.0	0.1	-0.3	-0.0
Pavlov. Cond. magazine entry number	0.4	0.5	1.9	0.0	-0.7	0.6	0.8	-0.0	1.4	1.0	0.4	0.6	0.1	-0.4
Pavlov. Cond. intertrial magazine entries	0.3	0.3	1.0	0.8	0.2	-0.3	-0.1	0.7	0.9	0.1	-0.6	-0.4	1.0	0.3
Pavlov. Cond. lever-magazine prob. diff.	0.3	0.4	1.9	0.1	0.7	-0.5	-0.8	0.0	-1.4	-0.7	-0.2	-0.3	-0.3	0.0
Pavlov. Cond. response bias	0.3	0.3	1.0	0.2	0.8	-0.5	-0.8	-0.0	-1.0	-0.8	-0.3	-0.3	-0.2	0.4
Pavlov. Cond. lever latency	0.2	0.3	0.7	-0.5	-0.3	0.3	0.4	-0.6	0.8	0.1	0.5	0.8	-0.5	0.3
Pavlov. Cond. magazine entry latency	0.4	0.5	1.3	0.5	0.6	-0.8	-0.6	0.9	-0.2	-0.6	-0.8	-1.1	0.8	0.6
Pavlov. Cond. change in total contacts	0.2	0.2	1.1	0.2	-0.0	0.1	0.2	0.5	-0.3	0.7	-0.2	-0.6	0.5	-1.1
Pavlov. Cond. index score	0.2	0.3	1.0	0.4	0.4	-0.5	-0.4	0.7	-0.5	-0.1	-0.6	-1.0	0.7	-0.1
Pavlov. Cond. latency score	0.2	0.3	0.9	0.5	0.3	-0.4	-0.3	0.7	-0.2	-0.1	-0.6	-1.0	0.8	-0.0
Pavlov. Cond. lever contacts	0.1	0.2	0.8	0.0	-0.2	0.2	0.2	0.0	-0.8	0.4	0.0	-0.3	-0.1	-0.9
Pavlov. Cond. magazine entry number	0.7	0.9	2.4	-1.0	-0.6	0.8	0.6	-1.2	-0.0	0.3	1.1	1.5	-1.4	-0.4
Pavlov. Cond. intertrial magazine entries	1.2	1.6	3.2	-1.2	-1.2	1.2	1.0	-1.6	0.7	0.7	1.5	1.8	-1.5	-0.6
Pavlov. Cond. lever-magazine prob. diff.	0.2	0.2	0.8	0.4	0.3	-0.4	-0.3	0.7	-0.4	-0.0	-0.6	-0.9	0.6	-0.2
Pavlov. Cond. response bias	0.2	0.3	1.3	0.3	0.3	-0.4	-0.4	0.6	-1.1	-0.2	-0.5	-0.9	0.3	-0.4
Time in closed arm before self-admin	1.2	1.3	3.2	-1.4	-1.5	1.0	0.7	-1.4	0.1	0.3	1.4	1.4	-1.8	0.0
Time in closed arm after self-admin	0.8	0.8	1.9	-1.2	-0.6	0.6	0.5	-1.1	0.3	0.4	1.1	1.2	-1.4	-0.2
Time in open arm before self-admin	0.4	0.4	1.0	0.9	0.5	-0.3	0.0	0.8	0.1	0.4	-0.6	-0.7	1.0	-0.8
Time in open arm after self-admin	1.2	1.3	1.8	0.9	0.8	-1.1	-1.2	1.2	-0.8	-1.3	-1.3	-1.3	1.2	1.1
Bone: periosteal estimation	0.0	0.1	0.2	0.3	0.2	-0.1	-0.4	0.3	-0.1	-0.3	-0.1	-0.0	0.1	0.4
Bone: periosteal perimeter	0.6	1.0	1.7	-0.9	-1.2	1.3	1.0	-1.0	0.5	0.9	1.1	1.1	-1.0	-0.8
Bone: post-yield work	0.6	0.8	1.5	0.3	0.7	-0.8	-1.0	0.9	-1.2	-1.0	-0.9	-1.2	0.6	0.5
Progressive ratio test 1 active lever presses	1.0	1.1	8.0	-2.8	-1.0	0.2	0.6	-1.0	-0.7	-0.3	0.4	-0.1	-0.7	-0.6
Progressive ratio test 1 breakpoint	1.5	1.5	9.9	-3.1	-1.3	0.5	0.9	-1.2	-0.6	-0.0	0.7	0.1	-0.9	-1.0
Progressive ratio test 1 inactive lever presses	1.5	1.7	9.5	-3.1	-1.4	0.8	0.9	-1.4	-0.1	0.1	1.1	0.6	-1.2	-0.6
Progressive ratio test 2 active lever presses	0.4	0.4	2.5	-1.6	-0.1	-0.2	-0.2	-0.8	-0.7	-0.8	0.1	0.0	-0.6	0.2
Progressive ratio test 2 breakpoint	0.4	0.5	2.8	-1.7	-0.2	-0.2	-0.1	-0.9	-0.6	-0.7	0.2	0.1	-0.6	0.2
Progressive ratio test 2 inactive lever presses	0.8	1.0	4.1	-2.0	-0.8	0.4	0.4	-1.4	-0.6	-0.4	0.8	0.8	-1.4	-0.2
Incentive Sensitization - Responses	0.6	0.6	1.9	0.4	0.8	-0.9	-1.0	-0.1	-1.1	-1.4	-0.2	0.2	-0.3	0.9
Incentive Sensitization - Breakpoint	0.6	0.6	1.8	0.4	0.9	-0.9	-1.0	-0.2	-1.2	-1.3	-0.2	0.3	-0.4	0.9
Sum of active levers in priming session hrs 5-6	0.3	0.3	0.6	0.2	0.5	-0.3	-0.4	0.5	0.7	-0.3	-0.6	-0.5	0.7	0.7
Progressive ratio	1.4	1.7	4.7	-2.2	-1.5	0.9	0.8	-1.0	-1.4	0.4	1.1	0.8	-1.7	-1.4
Food seeking constrained by brief footshock	1.0	1.2	2.6	-1.6	-1.5	1.5	1.4	-0.9	0.7	1.1	0.9	0.3	-0.7	-0.8
Seeking ratio, punishment vs. effort	0.4	0.5	3.3	0.8	0.1	0.4	0.4	0.1	1.8	0.7	-0.1	-0.1	0.7	0.4
Retroperitoneal fat weight	0.4	1.2	2.4	0.1	-0.6	1.5	1.0	-1.2	1.5	1.6	1.1	1.1	-0.5	-0.8
Reaction time number correct	0.9	1.2	4.1	-1.4	-2.0	1.4	1.2	-0.8	0.7	1.1	0.9	0.5	-0.4	-0.8
Reaction time mean minus median	0.3	0.3	1.0	0.2	-0.0	-0.3	-0.2	0.3	1.0	-0.4	-0.5	-0.4	0.9	1.0
Reaction time mean minus median AUC	0.4	0.5	2.1	0.5	0.1	-0.1	-0.1	0.2	1.4	-0.2	-0.6	-0.5	1.1	1.1
Reaction time num false alarms	0.9	1.2	3.3	1.4	0.6	-0.4	-0.2	1.5	0.8	0.5	-1.2	-1.6	1.8	-0.1
Reaction time num false alarms AUC	0.6	0.8	2.0	1.1	0.4	-0.4	-0.1	1.3	0.3	0.5	-1.0	-1.4	1.4	-0.3
Reaction time trials correct on left	0.9	1.2	4.1	-1.4	-2.0	1.4	1.2	-0.8	0.7	1.1	0.9	0.5	-0.4	-0.8
Reaction time trials on left	0.8	1.1	3.8	-1.3	-2.0	1.3	1.1	-0.7	0.6	1.0	0.8	0.4	-0.3	-0.7
Reaction time mean	0.3	0.4	1.2	0.8	0.8	-0.4	-0.3	0.5	0.5	-0.2	-0.7	-0.6	1.1	0.4
Reaction time mean AUC	0.1	0.2	0.6	0.6	0.3	-0.1	0.0	0.1	0.7	0.1	-0.3	-0.3	0.8	0.2
Median of all reaction times	0.4	0.6	1.4	1.0	1.2	-0.7	-0.5	0.7	0.1	-0.2	-0.9	-0.8	1.1	0.2
Reaction time omissions	0.7	0.9	1.6	1.1	0.8	-0.9	-0.7	1.2	-0.5	-0.7	-1.2	-1.3	1.3	0.5
Reaction time false alarm rate	0.8	1.0	2.4	1.6	1.2	-1.0	-0.7	1.3	-0.2	-0.2	-1.2	-1.2	1.2	0.1
Reaction time premature initiation rate	3.1	4.1	10.5	-3.2	-2.3	1.8	1.9	-1.9	-1.1	1.5	1.9	1.4	-2.2	-2.3
Reaction time premature initiations	3.2	4.6	11.7	-3.4	-2.8	2.1	2.2	-1.8	-0.6	1.8	1.9	1.2	-1.9	-2.3
Std. dev. reaction times	0.2	0.3	1.0	0.2	0.1	-0.1	-0.0	0.1	1.0	-0.1	-0.5	-0.5	1.0	0.6
Reaction time trials completed	0.8	1.1	3.8	-1.3	-2.0	1.3	1.1	-0.7	0.6	1.0	0.8	0.4	-0.3	-0.7
Reaction time trials AUC	0.6	0.9	3.6	-1.3	-1.9	1.2	1.0	-0.6	0.5	0.8	0.7	0.4	-0.3	-0.6
Run reversals in cocaine runway, females	0.1	0.1	0.1	-0.2	-0.3	0.3	0.4	-0.0	0.4	0.3	0.3	0.2	-0.3	-0.1
Run reversals in cocaine runway, males	0.0	0.0	0.1	-0.1	-0.2	0.2	-0.0	-0.2	0.1	0.1	0.0	-0.1	-0.0	0.0
Latency to leave start box in cocaine runway	1.6	1.7	2.7	1.6	1.5	-1.1	-1.1	1.2	0.2	-1.0	-1.4	-1.5	1.6	1.5
Latency to leave start box in cocaine runway, F	1.0	1.1	1.6	1.3	1.1	-1.0	-1.0	1.1	0.0	-0.9	-1.1	-1.1	1.2	1.1
Latency to leave start box in cocaine runway, M	0.4	0.4	0.9	0.7	0.7	-0.2	-0.3	0.5	0.5	-0.1	-0.6	-1.0	0.9	0.6
Std. dev. time between licks in bursts	0.5	0.6	2.1	1.5	1.1	-0.6	-0.8	0.6	-0.2	-0.5	-0.7	-0.5	0.7	0.6
Total sessions with >9 infusions	1.0	1.1	6.4	-2.5	-1.0	0.8	0.9	-1.0	-0.1	0.4	0.5	-0.2	-0.5	-1.0
Short access day 1 total inactive lever presses	0.5	0.6	2.3	-1.5	-0.5	0.2	0.1	-0.8	-0.5	-0.4	0.7	0.8	-1.2	0.1
Short access day 10 total inactive lever presses	0.1	0.2	0.7	0.1	0.3	0.1	-0.0	-0.4	0.1	-0.1	0.5	0.8	-0.6	0.3
Short access day 1 total infusions	0.4	0.4	2.1	-1.4	0.1	-0.4	-0.1	0.1	0.1	-0.7	-0.5	-0.9	0.6	0.4
Short access day 10 total infusions	0.6	0.6	2.1	-1.4	-0.1	-0.6	-0.2	0.5	-0.5	-0.8	-0.8	-1.4	0.8	0.4
Short access total infusions	0.5	0.5	4.9	-2.2	-0.5	0.1	0.4	-0.4	0.1	-0.3	-0.1	-0.6	0.1	-0.0
Short access day 1 locomotion	0.6	0.6	3.9	-2.0	-0.4	-0.1	0.1	-0.6	-1.1	-0.5	0.2	-0.3	-0.6	-0.5
Short access day 10 total locomotion	1.6	1.8	5.8	0.5	1.1	-1.7	-1.5	1.1	-2.4	-1.8	-1.1	-0.9	0.2	0.6
Short access total locomotion	0.9	0.9	4.8	-2.2	-0.4	-0.3	-0.1	-0.6	-1.7	-0.9	0.2	-0.2	-0.8	-0.4
One hour access (0.3 mA shock)	0.2	0.2	1.3	-1.1	-0.3	-0.1	0.0	-0.4	0.2	-0.5	-0.1	-0.2	-0.1	0.6
Compulsive drug intake	0.4	0.4	1.8	1.3	0.6	0.3	0.1	0.0	1.2	0.7	0.1	0.7	0.3	0.0
One hour access (shock baseline)	0.9	1.1	6.2	-2.5	-1.5	0.4	0.5	-1.0	-0.6	-0.4	0.6	0.2	-1.1	-0.1
Social response proportion	0.4	0.4	1.4	-0.3	0.4	-0.5	-0.4	0.3	-1.2	-0.5	-0.6	-1.2	0.3	-0.1
Social responses	0.2	0.3	1.2	-0.9	-0.2	-0.2	-0.1	-0.4	-1.1	-0.4	0.3	0.0	-0.8	-0.1
Social time	0.1	0.1	1.1	-1.0	-0.2	0.1	-0.0	-0.2	-0.3	-0.2	0.1	0.1	-0.4	0.2
Soleus weight	1.2	3.7	11.1	1.0	1.6	-2.3	-2.2	1.8	-3.3	-2.2	-1.7	-1.7	0.9	0.7
Bone: stiffness	0.6	0.9	2.0	1.2	1.4	-0.7	-0.8	1.0	0.5	-0.5	-0.9	-1.2	1.1	0.8
Tibialis anterior weight	7.6	26.0	36.7	4.3	5.2	-5.9	-6.1	5.1	-5.0	-5.8	-5.3	-4.8	3.9	4.4
Time to tail flick, vehicle, before self-admin	2.0	2.0	3.7	-0.9	-1.9	1.9	1.7	-1.1	1.6	1.8	1.3	0.9	-0.7	-1.1
Time to tail flick, vehicle, after self-admin	4.0	4.3	7.6	-2.7	-2.7	1.9	1.7	-2.4	0.0	1.3	2.3	2.3	-2.5	-1.5
Time to tail flick, test, before self-admin	3.0	2.9	5.3	-2.2	-1.6	1.4	1.1	-1.8	-1.3	0.7	1.9	2.1	-2.3	-1.6
Time to tail flick, test, after self-admin	7.0	7.2	10.0	-3.2	-3.0	2.7	2.7	-2.7	-0.2	2.4	2.8	2.6	-2.9	-3.1
Delta time to tail flick, vehicle, before/after SA	0.5	0.5	1.3	-1.1	-0.4	0.4	0.5	-0.8	-0.6	0.2	0.7	0.8	-1.0	-0.7
Delta time to tail flick, test, before/after SA	0.3	0.3	0.7	-0.1	-0.7	0.5	0.8	-0.3	0.5	0.8	0.3	0.1	0.0	-0.8
Tibia length	3.6	10.1	16.0	-3.5	-3.4	3.2	2.9	-3.8	0.6	2.1	3.7	3.8	-4.0	-2.0
Ambulatory time before self-admin	0.2	0.2	0.4	0.6	-0.5	-0.3	-0.4	-0.2	-0.2	-0.5	0.1	0.6	-0.5	0.6
Ambulatory time after self-admin	0.4	0.4	1.0	-1.0	-0.7	0.1	-0.0	-0.9	-0.2	-0.2	0.6	1.0	-1.0	0.4
Bone: tissue strength	1.1	1.0	2.8	1.1	1.7	-1.1	-1.1	0.9	-0.5	-0.8	-1.0	-0.9	0.9	0.7
Total heroin consumption	0.8	0.9	1.9	0.4	0.8	-1.1	-1.1	0.8	-1.0	-1.4	-1.0	-0.8	0.4	1.0
Bone: trabecular number	3.1	4.8	6.2	2.5	2.5	-2.4	-2.3	2.4	-0.6	-2.2	-2.2	-1.8	2.1	2.5
Bone: trabecular spacing	2.2	2.8	3.9	-1.6	-1.7	1.9	1.9	-2.0	0.8	1.8	1.7	1.5	-1.6	-1.8
Bone: trabecular thickness	2.7	3.2	4.5	2.0	2.1	-1.9	-1.8	2.0	-0.6	-1.6	-1.9	-1.7	1.8	1.7
Bone: trabecular tissue density	0.0	0.0	0.1	-0.2	-0.2	0.0	0.1	-0.2	0.1	-0.3	0.0	0.1	-0.0	0.3
Water consumed over 24 hours	0.1	0.2	0.7	-0.6	-0.4	0.1	0.0	0.2	-0.8	0.0	-0.0	-0.7	0.0	-0.4
Number of responses in last shaping day	2.6	2.7	6.3	-2.4	-1.8	1.4	2.0	-1.3	-0.1	1.7	1.5	0.7	-1.2	-2.5