Slc22a25

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	PL	isoform ratio	XR_010060855.1	0.03	0.02	2.4e-03	0	0.01	0	0	1.1e-01	1.8e-02	1.2e-01	9.1e-02
2	NAcc	gene expression	Slc22a25	0.02	0.02	2.0e-03	0	0.02	0.01	0.01	7.9e-02	1.6e-03	3.8e-03	4.0e-03
3	Liver	isoform ratio	XR_010060820.1	0.05	0.04	1.4e-03	0.03	0.01	0.03	0.02	4.4e-04	4.2e-02	6.6e-04	3.9e-03
4	Liver	isoform ratio	XR_010060881.1	0.07	0.04	2.2e-05	0.04	0.04	0.03	0.04	4.0e-05	6.0e-05	2.2e-04	7.2e-05
5	Liver	intron excision ratio	chr1_214900967_214906858	0.05	0.03	2.7e-04	0.02	0.03	0.02	0.03	3.4e-03	3.9e-04	1.4e-03	8.1e-04
6	Liver	intron excision ratio	chr1_214906962_214927535	0.07	0.05	5.7e-04	0.02	0.01	0.01	0.02	1.9e-03	1.7e-02	1.7e-02	6.3e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6
Bone: apparent density	0.1	0.3	0.4	-0.3	0.7	-0.7	0.7	-0.0	0.4
Area under the delay curve	0.3	0.5	1.0	0.1	-0.6	0.7	-0.7	1.0	-0.7
BMI with tail	0.2	0.8	1.6	-1.3	1.2	0.8	-0.8	0.8	-0.0
BMI without tail	0.5	2.6	5.9	-0.6	-0.4	2.4	-2.4	1.4	-1.2
Body weight	0.6	2.5	8.0	-2.8	1.9	1.3	-1.3	-0.1	-0.1
Weight adjusted by age	0.3	0.8	1.5	-0.9	1.2	-0.8	0.8	-0.9	0.8
Bone surface	1.8	3.5	5.5	-1.4	2.3	-2.1	2.1	-1.4	1.5
Bone volume	1.4	2.7	4.3	-0.7	1.9	-2.1	2.1	-1.2	1.5
Breakpoint value in progressive ratio session	1.2	2.2	3.7	-1.9	1.9	-0.8	0.8	-1.9	1.0
Number of licking bursts	0.0	0.1	0.3	-0.0	0.0	0.6	-0.6	0.1	0.1
Context. condit. distance diff. score	0.9	1.1	2.3	0.9	-1.3	0.5	-0.5	1.5	-1.0
Locomotion velocity, session 1	1.1	1.2	2.2	0.1	-1.1	1.0	-1.0	1.3	-1.5
Locomotion distance, session 1	0.5	0.7	1.3	-0.4	-0.4	0.7	-0.7	1.1	-1.1
Locomotion velocity, session 2	0.5	0.6	2.2	-1.5	1.0	0.4	-0.4	-0.4	0.1
Locomotion distance, session 2	1.0	1.4	3.3	-0.4	-0.4	1.8	-1.8	0.7	-0.9
Locomotion velocity, session 3	0.6	0.7	1.6	0.1	-0.4	1.0	-1.0	1.3	-0.7
Locomotion distance, session 3	0.2	0.3	0.6	-0.2	-0.5	0.3	-0.3	0.7	-0.8
Stereotopy head waving bouts, day 3	1.6	2.0	3.8	1.1	-0.8	2.0	-2.0	1.4	-0.3
Stereotopy head waving duration, day 3	1.4	1.8	4.1	0.8	-0.7	2.0	-2.0	1.1	-0.5
Locomotion velocity, session 7	0.2	0.3	0.6	0.4	-0.1	0.7	-0.7	0.5	0.1
Locomotion distance, session 7	1.2	1.6	2.5	0.5	-1.2	1.4	-1.4	1.6	-1.1
Stereotopy head waving bouts, day 7	0.4	0.5	1.1	-0.1	1.0	-0.2	0.2	-0.8	1.0
Stereotopy head waving duration, day 7	0.8	1.0	2.6	-1.1	1.6	-0.0	0.0	-1.2	0.8
Locomotion velocity, session 8	1.3	1.6	2.5	-0.0	-1.2	1.6	-1.6	1.1	-1.4
Locomotion distance, session 8	0.7	1.1	2.0	1.1	-1.0	0.9	-0.9	1.4	-0.7
Degree of sensitization distance	0.6	0.6	1.1	0.8	-0.5	0.9	-0.9	1.1	-0.2
Degree of sensitization stereotypy	1.4	1.6	3.1	-0.8	1.8	-0.8	0.8	-1.6	1.4
Conditioned locomotion	0.4	0.5	1.0	-0.8	0.3	1.0	-1.0	-0.0	-0.1
Cocaine response after cond. corrected	2.0	3.0	3.8	0.9	-1.9	1.9	-1.9	1.9	-1.7
Cocaine response after cond. not corrected	0.7	1.0	1.9	0.7	-1.3	0.2	-0.2	1.4	-1.2
Cocaine response before conditioning	5.5	6.6	15.6	-0.8	1.7	-3.9	3.9	-1.8	1.4
Saline control response	0.7	0.9	4.4	-2.1	0.8	-0.2	0.2	-0.2	-0.7
Bone: connectivity density	0.6	0.9	1.6	-1.2	1.3	-1.1	1.1	-0.4	0.3
Bone: cortical apparent density	0.3	0.5	0.8	-0.9	0.5	-0.7	0.7	-0.8	0.2
Bone: cortical area	1.5	2.4	4.5	-0.9	1.5	-2.1	2.1	-1.0	1.1
Bone: cortical porosity	0.3	0.3	0.6	-0.2	0.3	0.7	-0.7	-0.7	0.4
Bone: cortical porosity	0.4	0.4	1.0	-0.4	0.2	1.0	-1.0	-0.5	0.1
Bone: cortical thickness	1.3	2.1	8.3	-2.9	1.3	-0.9	0.9	-1.1	-0.3
Bone: cortical thickness	0.3	0.4	1.1	-1.0	-0.4	0.1	-0.1	0.4	-1.1
Bone: cortical tissue density	0.3	0.5	1.2	-1.1	0.6	-0.6	0.6	-0.9	0.2
Condit. Reinf. active minus inactive responses	0.5	0.6	1.1	-1.1	0.9	-0.8	0.8	-0.6	0.3
Condit. Reinf. active-inactive response ratio	0.2	0.3	0.8	-0.9	0.5	-0.4	0.4	-0.5	-0.1
Condit. Reinf. active responses	1.0	1.2	1.8	-0.7	1.4	-1.2	1.2	-0.9	1.0
Condit. Reinf. inactive responses	0.7	0.9	1.6	0.5	0.7	-1.2	1.2	-0.4	1.3
Incentive salience index mean	0.5	0.6	1.0	-1.0	0.9	-0.9	0.9	-0.3	0.2
Condit. Reinf. lever presses	0.5	0.7	1.4	-0.7	0.9	-1.2	1.2	-0.3	0.4
Condit. Reinf. active minus inactive responses	1.1	1.7	3.2	0.4	0.8	-1.8	1.8	-1.1	1.3
Condit. Reinf. active-inactive response ratio	1.3	2.0	4.0	1.2	1.1	-1.5	1.5	-1.2	2.0
Condit. Reinf. active responses	0.7	1.0	2.3	-0.3	0.7	-1.5	1.5	-0.7	0.5
Condit. Reinf. inactive responses	0.5	0.7	1.7	-0.9	-0.6	-0.7	0.7	0.6	-1.3
Condit. Reinf. lever presses	1.1	1.6	2.2	-0.9	1.5	-1.5	1.5	-1.1	0.9
Condit. Reinf. lever reinforcers received	1.0	1.4	2.7	-0.6	0.9	-1.6	1.6	-1.0	0.7
Conditioned reinforcement - actives	0.8	3.1	4.7	0.7	1.3	-2.2	2.2	-1.6	2.2
Conditioned reinforcement - inactives	0.9	2.4	3.8	0.8	1.2	-2.0	2.0	-1.0	1.9
Conditioned locomotion	0.8	1.3	5.3	2.3	-1.0	-0.3	0.3	1.0	0.3
Patch foraging indifference point 0 sec	0.1	0.2	0.6	-0.8	0.5	0.2	-0.2	-0.1	-0.2
Patch foraging indifference point AUC	1.8	4.2	6.2	-1.4	2.4	-1.8	1.8	-2.5	2.1
Delay disc. indifference point, 0s delay	1.4	1.6	3.1	1.0	-1.4	1.1	-1.1	1.8	-1.1
Delay disc. indifference point, 16s delay	0.1	0.1	0.2	0.0	0.4	-0.4	0.4	-0.1	0.4
Delay disc. indifference point, 2s delay	0.2	0.3	0.9	1.0	-0.4	-0.3	0.3	0.6	0.1
Delay disc. indifference point, 24s delay	0.3	0.5	0.8	-0.3	-0.6	0.8	-0.8	0.8	-0.9
Delay disc. indifference point, 4s delay	1.3	1.4	2.1	-0.3	-0.9	1.3	-1.3	1.4	-1.4
Delay disc. indifference point, 8s delay	0.9	1.5	1.9	0.6	-1.3	1.4	-1.4	1.3	-1.2
Indifference point function ln k	2.9	8.9	14.6	2.3	-3.8	2.1	-2.1	3.8	-3.2
Indifference point function log k	2.9	8.9	14.6	2.3	-3.8	2.1	-2.1	3.8	-3.2
Patch foraging total patch changes 0 sec	0.1	0.3	1.0	-1.0	0.1	0.3	-0.3	0.2	-0.7
Patch foraging total patch changes 12 sec	2.8	3.8	8.8	-3.0	2.6	-0.8	0.8	-2.1	1.1
Patch foraging total patch changes 18 sec	0.4	1.1	1.7	-1.0	1.3	-0.8	0.8	-1.3	0.9
Patch foraging total patch changes 24 sec	0.7	2.3	7.6	-2.8	2.1	0.1	-0.1	-1.2	0.4
Patch foraging total patch changes 6 sec	0.2	0.4	1.6	-1.3	0.6	-0.4	0.4	-0.1	-0.2
Patch foraging time to switch 0 sec	0.1	0.5	1.2	-0.0	1.1	-0.4	0.4	-0.6	1.1
Patch foraging water rate 0 sec	0.1	0.5	1.3	0.5	-1.1	0.1	-0.1	0.8	-1.0
Patch foraging water rate 12 sec	1.0	4.2	8.3	1.4	-2.9	1.2	-1.2	2.5	-2.5
Patch foraging water rate 18 sec	1.9	4.2	7.4	0.7	-2.4	1.5	-1.5	2.6	-2.7
Patch foraging water rate 24 sec	1.3	1.8	3.8	1.1	-1.9	0.7	-0.7	1.6	-1.6
Patch foraging water rate 6 sec	2.5	3.6	6.8	1.1	-2.6	1.3	-1.3	2.3	-2.3
Seeking ratio, delayed vs. immediate footshock	0.0	0.0	0.1	-0.1	-0.1	0.2	-0.2	0.3	-0.3
Distance traveled before self-admin	1.3	2.8	4.7	-1.4	2.2	-1.6	1.6	-1.6	1.5
Distance traveled after self-admin	0.5	0.9	1.4	-1.0	1.1	-0.7	0.7	-1.2	0.7
Extensor digitorum longus weight	1.6	6.5	22.6	-4.8	3.3	1.2	-1.2	-1.5	0.2
Bone: elastic displacement	1.0	1.3	2.3	0.2	-1.2	1.5	-1.5	0.8	-1.1
Bone: elastic work	1.1	1.4	2.2	-1.3	-0.4	1.5	-1.5	0.7	-1.4
Bone: endosteal estimation	0.6	1.5	6.1	2.5	-0.6	-0.3	0.3	1.3	0.7
Bone: endosteal perimeter	1.1	2.6	8.3	2.9	-0.1	-1.4	1.4	0.6	1.7
Epididymis fat weight	0.3	1.5	5.3	2.3	-0.0	-0.9	0.9	0.3	1.4
Delta time in closed arm before/after self-admin	3.7	3.4	5.2	-0.9	-1.2	2.3	-2.3	1.8	-2.2
Delta time in open arm before/after self-admin	3.4	4.0	6.0	-1.2	2.4	-1.9	1.9	-2.2	2.1
Diff in mean of infusions in LGA sessions	0.5	1.0	4.0	-2.0	1.1	0.1	-0.1	-0.8	-0.1
Delay discount exponential model param	0.3	0.4	0.8	-0.1	0.5	-0.7	0.7	-0.9	0.7
Extinction: sum of active levers before priming	1.0	1.5	3.7	-1.9	1.7	-0.6	0.6	-1.1	0.6
Active lever presses in extinction session 6	4.0	4.0	5.7	-1.7	2.4	-2.0	2.0	-2.1	1.7
Bone: final force	1.1	1.7	2.9	-1.2	1.5	-1.7	1.7	-0.7	0.7
Bone: final moment	1.0	1.5	2.3	-1.3	1.5	-1.5	1.5	-0.7	0.6
Food consumed during 24 hour testing period	0.3	0.7	1.6	0.2	0.4	-1.3	1.3	-0.5	0.5
Glucose	1.5	2.4	6.1	2.5	-1.8	0.8	-0.8	1.9	-0.5
Heart weight	2.6	4.2	6.2	1.1	-1.8	2.4	-2.4	2.5	-1.7
Delay discount hyperbolic model param	0.3	0.3	0.8	-0.2	0.5	-0.5	0.5	-0.9	0.6
Intermittent access intake day 1-15 change	0.4	2.3	3.4	1.4	0.5	-1.8	1.8	-1.2	1.8
Intermittent access intake escalation	0.5	2.8	4.2	1.6	0.5	-2.0	2.0	-1.3	2.0
Intermittent access intake escalation 2	1.6	2.7	4.2	0.9	1.0	-2.0	2.0	-1.5	2.0
Intermitt. access day 1 inactive lever presses	0.1	0.8	1.3	1.1	0.0	-1.0	1.0	-0.6	1.0
Intermitt. access day 15 inactive lever presses	0.6	3.0	4.3	-0.1	1.9	-2.1	2.1	-1.3	2.1
Intermitt. access escalation Index	0.3	1.1	1.7	0.8	-1.3	1.0	-1.0	1.0	-1.0
Intermittent access day 1 total infusions	0.4	1.2	4.2	2.1	-0.5	-0.4	0.4	1.5	0.4
Intermittent access day 15 total infusions	1.3	3.2	9.2	3.0	-0.2	-1.8	1.8	0.2	1.8
Intermittent access terminal intake (last 3 days)	1.8	3.1	5.4	2.3	0.5	-2.1	2.1	-0.1	2.1
Intermittent access total infusions	1.4	1.7	5.3	2.3	-0.1	-1.2	1.2	0.7	1.2
Intermittent access day 1 locomotion	0.3	0.6	1.7	1.3	-0.4	-0.1	0.1	1.2	0.1
Intermittent access day 15 total locomotion	0.6	2.3	3.6	1.4	0.9	-1.9	1.9	-0.4	1.9
Intermittent access total locomotion	2.5	2.9	4.3	2.0	0.8	-2.1	2.1	0.1	2.1
Intermittent access standard deviation	0.2	0.9	1.6	1.3	0.1	-1.1	1.1	-0.4	1.1
Left kidney weight	0.1	0.5	1.9	1.4	-0.1	-0.4	0.4	0.5	0.7
Right kidney weight	0.0	0.3	0.9	1.0	0.1	-0.2	0.2	0.1	0.8
Cocaine induced anxiety	0.3	0.9	1.2	-0.2	0.9	-1.1	1.1	-1.1	1.1
Post-drug Anxiety	0.5	0.6	0.8	-0.6	0.9	-0.7	0.7	-0.9	0.7
Baseline Anxiety	0.6	1.1	1.6	-0.7	-0.5	1.3	-1.3	0.8	-1.3
Tail length	0.2	1.1	2.5	-1.6	0.1	1.3	-1.3	-0.2	-0.9
Length with tail	0.4	1.7	7.3	-2.7	1.4	0.4	-0.4	-0.9	-0.2
Length without tail	0.4	2.3	10.2	-3.2	1.6	0.3	-0.3	-0.7	-0.4
Times rat made contact with spout	0.3	0.4	0.8	-0.7	-0.4	0.6	-0.6	0.3	-0.9
Lifetime Intake	0.8	1.1	4.1	2.0	-0.6	-0.4	0.4	1.2	0.4
Liver weight, left	0.4	0.7	1.7	1.3	-1.3	0.3	-0.3	0.9	-0.4
Liver weight, right	1.6	2.9	5.7	1.8	-2.3	0.4	-0.4	2.4	-1.6
Locomotor activity	2.3	3.6	4.9	0.6	-2.2	2.0	-2.0	1.9	-2.2
Locomotor testing distance	1.7	4.2	6.7	0.8	-2.6	1.6	-1.6	2.4	-2.6
Locomotor testing rearing	0.6	2.3	4.9	1.0	-2.2	0.4	-0.4	2.0	-2.0
Locomotion in novel chamber	0.8	1.0	4.0	2.0	-0.6	-0.8	0.8	0.4	0.7
Locomotion in novel chamber post-restriction	0.3	0.8	3.3	1.8	-0.5	-0.4	0.4	-0.1	0.9
Fecal boli incidents, locomotor time 1	0.7	1.9	3.0	0.6	1.1	-1.6	1.6	-1.3	1.7
Change in fecal boli incidents, locomotor task	2.6	2.7	4.0	1.1	-2.0	1.6	-1.6	1.9	-1.6
Time >=10cm from walls, locomotor time 1	1.6	2.0	4.0	2.0	0.4	-1.5	1.5	-0.5	1.8
Bouts of movement, locomotor time 1	1.3	1.6	4.2	-1.2	1.2	-0.9	0.9	-2.1	0.9
Total resting periods, locomotor time 1	1.6	1.8	4.2	-1.0	1.3	-1.1	1.1	-2.0	1.2
Rest time, locomotor task time 1	0.2	0.3	1.5	1.2	-0.5	-0.2	0.2	-0.1	0.4
Distance moved, locomotor task time 1	0.0	0.0	0.1	-0.3	0.1	-0.0	0.0	0.3	-0.2
Vertical activity count, locomotor time 1	0.1	0.4	0.6	0.8	-0.8	0.3	-0.3	0.7	-0.4
Time >=10cm from walls, locomotor time 2	0.7	2.0	2.7	0.1	1.2	-1.6	1.6	-1.6	1.6
Bouts of movement, locomotor time 2	0.2	0.7	2.0	-1.4	1.1	-0.2	0.2	-0.9	0.3
Total resting periods, locomotor time 2	0.1	0.4	0.9	-1.0	0.8	-0.2	0.2	-0.8	0.4
Rest time, locomotor task time 2	0.7	1.2	4.0	2.0	-1.4	0.3	-0.3	0.9	-0.2
Distance moved, locomotor task time 2	0.4	0.5	1.3	-1.1	0.7	-0.4	0.4	-0.9	0.2
Vertical activity count, locomotor time 2	0.2	0.5	0.9	-0.5	-0.6	0.9	-0.9	0.3	-0.9
Light reinforcement 1	0.1	0.4	1.1	-0.1	0.0	-1.0	1.0	-0.3	0.0
Light reinforcement 2	1.4	3.2	5.4	0.8	1.5	-2.0	2.0	-1.5	2.3
Bone: marrow area	0.7	1.6	6.8	2.6	-0.8	-0.1	0.1	1.4	0.6
Bone: maximum diameter	1.0	1.9	3.2	0.2	1.3	-1.8	1.8	-0.9	1.6
Bone: maximum force	1.4	2.7	4.6	-1.3	2.1	-1.9	1.9	-1.0	1.3
Bone: maximum moment	1.3	2.4	4.3	-1.3	2.1	-1.7	1.7	-0.9	1.2
Mean time between licks in bursts	0.5	2.8	4.6	-0.9	-1.3	1.9	-1.9	1.6	-2.1
Mean num. licks in bursts	0.0	0.1	0.4	-0.1	-0.5	-0.1	0.1	0.2	-0.7
Cd content in liver	0.5	0.6	1.3	1.2	0.1	-0.7	0.7	-0.4	1.0
Co content in liver	1.0	1.2	2.7	0.3	-1.7	0.6	-0.6	1.0	-1.6
Cu content in liver	0.0	0.0	0.2	-0.2	-0.1	0.2	-0.2	-0.1	-0.4
Fe content in liver	0.1	0.1	0.2	0.2	-0.2	0.4	-0.4	0.3	-0.1
K content in liver	0.4	0.4	0.9	-0.4	0.1	-0.9	0.9	0.3	-0.2
Mg content in liver	0.5	0.5	1.5	0.2	-0.8	0.1	-0.1	1.2	-1.0
Mn content in liver	2.9	3.2	4.5	-1.8	2.1	-2.0	2.0	-1.6	1.1
Na content in liver	1.2	1.4	3.7	-0.5	0.6	-1.9	1.9	-0.3	0.4
Rb content in liver	2.5	2.9	4.8	1.7	-2.2	1.5	-1.5	1.8	-1.4
Se content in liver	1.1	1.3	2.0	0.0	1.2	-1.4	1.4	-1.0	1.3
Sr content in liver	1.9	1.7	4.1	-2.0	1.8	0.0	0.0	-1.5	0.8
Zn content in liver	0.6	0.7	2.6	-1.6	1.0	0.5	-0.5	-0.5	0.1
Bone: minimum diameter	0.6	1.1	3.5	1.9	-0.1	-0.9	0.9	0.7	1.0
Time in familiar zone, hab. session 1	0.2	0.2	0.6	-0.1	-0.1	-0.8	0.8	0.4	-0.2
Time in novel zone, hab. session 1	0.6	0.7	1.7	0.9	-1.3	0.3	-0.3	0.9	-0.9
Total zone transitions, hab. session 1	0.1	0.1	0.3	-0.6	0.2	0.3	-0.3	-0.1	-0.1
Total locomotion distance, hab. session 1	0.1	0.2	0.5	0.7	-0.0	-0.4	0.4	0.3	0.5
Locomotion velocity, hab. session 1	0.1	0.1	0.3	0.0	0.4	-0.3	0.3	-0.1	0.6
Time in familiar zone, hab. session 2	0.4	0.5	1.3	-0.1	-1.0	-0.4	0.4	0.6	-1.1
Time in novel zone, hab. session 2	0.1	0.2	0.4	-0.2	0.6	0.5	-0.5	-0.1	0.3
Total zone transitions, hab. session 2	0.3	0.4	1.1	-1.1	0.1	0.0	-0.0	0.6	-0.8
Total locomotion distance, hab. session 2	0.2	0.2	0.8	0.0	-0.4	-0.4	0.4	0.9	-0.5
Locomotion velocity, hab. session 2	0.1	0.2	0.5	0.3	-0.2	-0.5	0.5	0.7	-0.2
Novel to familiar place preference ratio	1.1	1.4	3.3	-1.3	1.8	0.4	-0.4	-1.4	1.2
Novelty place preference	0.9	1.1	2.6	-0.9	1.6	0.5	-0.5	-1.3	1.1
Time in novel zone, NPP test	0.8	1.0	2.1	-1.0	1.5	0.6	-0.6	-1.1	0.9
Total zone transitions, NPP test	0.3	0.4	1.3	-1.1	0.3	0.6	-0.6	0.1	-0.6
Total locomotion distance, NPP test	0.4	0.6	0.9	0.0	-0.6	0.9	-0.9	0.9	-0.7
Locomotion velocity, NPP test	0.2	0.4	0.6	0.0	-0.4	0.8	-0.8	0.6	-0.5
Intraocular pressure	0.2	0.3	1.1	-0.0	0.5	0.2	-0.2	-1.1	0.5
Delta distance traveled before/after self-admin	1.3	1.4	2.2	0.1	-1.4	1.2	-1.2	1.0	-1.5
Delta ambulatory time before/after self-admin	1.0	1.7	2.4	0.4	-1.6	1.4	-1.4	1.1	-1.5
Parametrial fat weight	0.8	1.9	7.8	2.8	-0.5	-0.6	0.6	0.7	1.4
Pavlov. Cond. lever latency	0.6	0.8	1.7	0.7	-0.9	1.3	-1.3	0.3	-0.4
Pavlov. Cond. magazine entry latency	2.8	3.6	7.8	-0.7	1.6	-2.8	2.8	-1.0	1.4
Pavlov. Cond. change in total contacts	4.1	4.5	9.4	-0.2	1.6	-3.1	3.1	-1.4	1.8
Pavlov. Cond. index score	2.1	2.6	5.6	-0.7	1.3	-2.4	2.4	-1.1	1.1
Pavlov. Cond. latency score	1.4	1.8	4.3	-0.6	1.0	-2.1	2.1	-0.6	0.7
Pavlov. Cond. lever contacts	0.6	0.8	2.0	-0.4	0.5	-1.4	1.4	-0.0	0.3
Pavlov. Cond. magazine entry number	2.9	3.7	7.1	1.0	-1.7	2.7	-2.7	1.6	-1.4
Pavlov. Cond. intertrial magazine entries	0.8	1.0	2.2	-0.4	1.1	-0.7	0.7	-1.5	1.1
Pavlov. Cond. lever-magazine prob. diff.	2.3	2.9	5.8	-0.7	1.5	-2.4	2.4	-1.2	1.3
Pavlov. Cond. response bias	2.7	3.3	6.7	-0.9	1.6	-2.6	2.6	-1.3	1.3
Pavlov. Cond. lever latency	0.7	0.9	1.4	0.7	-1.1	1.2	-1.2	0.8	-0.6
Pavlov. Cond. magazine entry latency	3.4	4.9	6.7	-2.6	2.5	-2.4	2.4	-2.0	1.0
Pavlov. Cond. change in total contacts	2.3	5.6	9.7	-1.3	2.3	-3.1	3.1	-2.0	1.7
Pavlov. Cond. index score	3.0	4.7	6.5	-1.8	2.4	-2.5	2.5	-2.0	1.5
Pavlov. Cond. latency score	2.8	4.6	6.5	-1.6	2.4	-2.5	2.5	-1.9	1.6
Pavlov. Cond. lever contacts	0.9	1.3	2.1	-0.7	1.2	-1.5	1.5	-1.0	0.7
Pavlov. Cond. magazine entry number	5.4	7.0	10.7	3.1	-3.3	2.5	-2.5	2.6	-1.5
Pavlov. Cond. intertrial magazine entries	0.2	0.5	2.0	1.4	-0.7	0.4	-0.4	0.1	0.3
Pavlov. Cond. lever-magazine prob. diff.	3.3	5.1	6.9	-1.9	2.6	-2.6	2.6	-2.1	1.5
Pavlov. Cond. response bias	1.7	2.4	3.1	-1.6	1.8	-1.7	1.7	-1.3	0.8
Time in closed arm before self-admin	0.7	1.1	1.8	0.5	0.9	-1.3	1.3	-0.8	1.4
Time in closed arm after self-admin	1.0	1.1	1.8	1.1	-1.3	0.8	-0.8	1.3	-0.9
Time in open arm before self-admin	6.2	7.6	9.7	0.6	-3.0	3.1	-3.1	2.8	-3.1
Time in open arm after self-admin	0.4	0.4	1.0	-1.0	0.1	0.7	-0.7	-0.0	-0.6
Bone: periosteal estimation	0.6	1.4	2.4	0.9	0.7	-1.5	1.5	-0.1	1.4
Bone: periosteal perimeter	1.0	1.9	4.0	0.6	0.9	-2.0	2.0	-0.5	1.5
Bone: post-yield work	1.4	2.4	4.1	1.4	1.0	-2.0	2.0	-0.2	1.8
Progressive ratio test 1 active lever presses	0.2	0.3	1.2	1.1	-0.2	-0.4	0.4	0.3	0.4
Progressive ratio test 1 breakpoint	0.2	0.4	1.2	1.1	-0.1	-0.6	0.6	0.2	0.6
Progressive ratio test 1 inactive lever presses	0.1	0.3	0.6	-0.4	0.8	-0.5	0.5	-0.3	0.5
Progressive ratio test 2 active lever presses	1.3	1.9	3.0	1.7	0.4	-1.6	1.6	-0.3	1.6
Progressive ratio test 2 breakpoint	1.4	1.9	2.8	1.7	0.4	-1.6	1.6	-0.3	1.6
Progressive ratio test 2 inactive lever presses	0.7	2.3	3.5	1.6	0.7	-1.9	1.9	-0.5	1.9
Incentive Sensitization - Responses	0.6	1.7	2.4	-0.1	1.5	-1.5	1.5	-0.9	1.5
Incentive Sensitization - Breakpoint	0.8	1.7	2.6	0.1	1.4	-1.6	1.6	-0.8	1.6
Sum of active levers in priming session hrs 5-6	6.8	6.3	10.6	-1.3	2.8	-2.3	2.3	-3.3	2.7
Progressive ratio	0.1	0.3	0.7	0.6	0.4	-0.5	0.5	-0.0	0.8
Food seeking constrained by brief footshock	0.2	0.2	0.4	0.2	-0.6	0.4	-0.4	0.6	-0.6
Seeking ratio, punishment vs. effort	0.8	1.8	3.0	-0.2	-1.3	1.5	-1.5	1.2	-1.7
Retroperitoneal fat weight	1.7	7.6	22.6	4.8	-3.3	1.2	-1.2	3.0	-0.6
Reaction time number correct	0.1	0.3	1.2	-1.1	0.1	-0.1	0.1	0.0	-0.7
Reaction time mean minus median	0.6	3.8	7.4	-0.9	2.4	-1.3	1.3	-2.7	2.4
Reaction time mean minus median AUC	0.3	1.8	4.1	-0.8	1.5	-0.9	0.9	-2.0	1.5
Reaction time num false alarms	1.7	2.8	4.7	0.1	-2.0	1.6	-1.6	1.8	-2.2
Reaction time num false alarms AUC	1.3	3.0	4.8	-0.5	-1.6	2.0	-2.0	1.5	-2.2
Reaction time trials correct on left	0.1	0.3	1.2	-1.1	0.1	-0.1	0.1	0.0	-0.7
Reaction time trials on left	0.1	0.3	1.3	-1.2	0.1	-0.1	0.1	-0.0	-0.7
Reaction time mean	0.8	1.8	2.7	-0.0	1.2	-1.5	1.5	-1.6	1.5
Reaction time mean AUC	0.8	1.9	2.9	0.2	1.1	-1.7	1.7	-1.6	1.5
Median of all reaction times	0.6	1.0	1.7	0.1	0.8	-1.3	1.3	-1.0	1.0
Reaction time omissions	0.5	0.8	1.9	-1.0	1.0	-0.5	0.5	-1.4	0.8
Reaction time false alarm rate	1.6	2.2	3.0	0.3	-1.6	1.7	-1.7	1.4	-1.6
Reaction time premature initiation rate	1.0	1.5	5.3	-2.3	0.2	0.5	-0.5	0.8	-1.6
Reaction time premature initiations	0.7	2.1	8.8	-3.0	0.4	0.4	-0.4	0.5	-1.7
Std. dev. reaction times	0.6	1.9	4.4	-0.2	1.4	-1.0	1.0	-2.1	1.8
Reaction time trials completed	0.1	0.3	1.3	-1.2	0.1	-0.1	0.1	-0.0	-0.7
Reaction time trials AUC	0.1	0.3	1.0	-1.0	-0.1	-0.0	0.0	0.2	-0.8
Run reversals in cocaine runway, females	2.7	3.0	4.5	-0.1	-1.3	2.0	-2.0	2.1	-1.9
Run reversals in cocaine runway, males	0.2	0.2	0.4	0.5	-0.6	0.4	-0.4	0.3	-0.3
Latency to leave start box in cocaine runway	0.3	0.4	1.3	1.1	-0.5	-0.1	0.1	0.8	0.2
Latency to leave start box in cocaine runway, F	0.0	0.0	0.0	0.1	0.1	-0.1	0.1	0.2	0.1
Latency to leave start box in cocaine runway, M	0.9	0.9	3.2	1.8	-1.1	-0.1	0.1	1.0	-0.0
Std. dev. time between licks in bursts	1.1	2.0	3.4	-0.0	-1.6	1.4	-1.4	1.6	-1.8
Total sessions with >9 infusions	0.5	0.6	1.9	1.4	-0.9	0.2	-0.2	0.9	-0.1
Short access day 1 total inactive lever presses	0.2	0.4	1.0	0.7	-0.6	0.4	-0.4	1.0	-0.4
Short access day 10 total inactive lever presses	0.0	0.3	0.7	0.7	-0.8	0.4	-0.4	0.5	-0.5
Short access day 1 total infusions	0.6	1.2	3.1	1.8	-1.3	0.4	-0.4	1.4	-0.4
Short access day 10 total infusions	0.4	0.7	2.3	1.5	-0.5	-0.2	0.2	1.1	0.2
Short access total infusions	1.1	1.5	3.3	1.6	-1.3	0.7	-0.7	1.8	-0.7
Short access day 1 locomotion	0.2	0.3	1.1	1.1	-0.3	-0.3	0.3	0.5	0.3
Short access day 10 total locomotion	0.1	0.4	0.6	0.7	0.4	-0.8	0.8	0.3	0.8
Short access total locomotion	0.3	0.4	1.3	1.1	0.0	-0.6	0.6	0.5	0.6
One hour access (0.3 mA shock)	1.0	1.2	3.8	1.9	-0.2	-1.0	1.0	0.5	1.0
Compulsive drug intake	1.2	1.8	2.8	-1.7	-0.4	1.6	-1.6	0.3	-1.6
One hour access (shock baseline)	1.2	3.3	8.8	3.0	-0.1	-1.9	1.9	0.1	1.9
Social response proportion	0.1	0.1	0.1	-0.2	-0.1	-0.3	0.3	0.1	-0.4
Social responses	0.1	0.2	0.4	-0.7	-0.1	-0.4	0.4	-0.1	-0.5
Social time	0.3	0.5	1.2	-0.4	-0.5	1.1	-1.1	0.1	-0.7
Soleus weight	1.1	3.3	8.7	2.9	-2.5	0.7	-0.7	1.8	-0.8
Bone: stiffness	1.7	3.1	5.0	-0.6	1.8	-2.2	2.2	-1.4	1.7
Tibialis anterior weight	3.1	10.8	31.4	-5.6	4.5	0.9	-0.9	-3.1	1.3
Time to tail flick, vehicle, before self-admin	0.1	0.1	0.3	0.3	0.4	-0.4	0.4	0.1	0.5
Time to tail flick, vehicle, after self-admin	0.2	0.3	0.8	-0.1	-0.3	0.5	-0.5	0.9	-0.7
Time to tail flick, test, before self-admin	1.5	1.7	3.0	0.2	-0.7	1.7	-1.7	1.7	-1.0
Time to tail flick, test, after self-admin	0.6	0.6	0.8	-0.1	0.8	-0.9	0.9	-0.9	0.9
Delta time to tail flick, vehicle, before/after SA	0.3	0.3	0.6	-0.5	-0.3	0.5	-0.5	0.5	-0.8
Delta time to tail flick, test, before/after SA	2.5	3.1	5.4	-0.7	1.5	-2.0	2.0	-2.3	1.6
Tibia length	2.7	7.5	11.2	-1.5	3.4	-2.7	2.7	-2.9	2.9
Ambulatory time before self-admin	1.3	4.0	5.7	-1.3	2.4	-2.1	2.1	-2.0	1.9
Ambulatory time after self-admin	0.6	0.9	1.3	-0.4	1.0	-1.2	1.2	-0.9	0.9
Bone: tissue strength	0.2	0.2	0.4	0.4	-0.6	0.0	-0.0	0.4	-0.6
Total heroin consumption	3.0	3.6	10.0	-3.2	2.4	-0.5	0.5	-2.2	0.8
Bone: trabecular number	0.3	0.5	1.5	-0.7	1.2	-0.7	0.7	-0.4	0.5
Bone: trabecular spacing	0.4	0.6	1.7	0.2	-1.3	0.3	-0.3	0.7	-1.2
Bone: trabecular thickness	0.3	0.4	1.0	0.6	0.4	-0.7	0.7	-0.4	1.0
Bone: trabecular tissue density	0.9	1.5	5.2	2.3	-1.8	0.4	-0.4	0.6	-0.4
Water consumed over 24 hours	0.1	0.3	1.4	-1.2	0.3	-0.0	0.0	-0.2	-0.5
Number of responses in last shaping day	0.5	0.7	1.1	-0.4	-0.5	1.0	-1.0	0.7	-1.0