Slc22a25

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Liver	isoform ratio	XM_039093100.1	0.03	0.02	5.0e-03	0.02	0.02	0	0.01	2.3e-03	4.7e-03	1.0e-01	7.1e-03
2	Liver	intron excision ratio	chr1_205471828_205477719	0.05	0.03	3.2e-04	0.01	0.03	0.03	0.03	1.1e-02	3.8e-04	4.6e-04	4.5e-04
3	Liver	intron excision ratio	chr1_205477823_205498396	0.06	0.04	1.0e-03	0.03	0.01	0.02	0.03	1.2e-04	2.7e-02	4.4e-03	6.4e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3
Bone: apparent density	0.1	0.2	0.5	0.7	-0.0	0.3
Area under the delay curve	0.5	0.5	1.0	-0.1	1.0	-0.7
BMI with tail	0.9	2.8	7.7	2.8	0.9	-0.1
BMI without tail	0.5	1.0	1.8	1.4	0.7	-0.7
Body weight	1.4	5.9	17.3	4.2	-0.5	-0.3
Weight adjusted by age	1.4	1.6	2.6	1.6	-1.1	1.0
Bone surface	1.5	2.6	3.5	1.9	-1.4	1.6
Bone volume	1.0	1.7	2.4	1.3	-1.1	1.6
Breakpoint value in progressive ratio session	2.5	2.7	4.3	1.6	-2.1	1.2
Number of licking bursts	0.0	0.0	0.0	0.1	-0.0	0.1
Context. condit. distance diff. score	1.2	1.4	2.5	-0.8	1.6	-1.1
Locomotion velocity, session 1	1.2	1.3	2.1	-0.4	1.2	-1.5
Locomotion distance, session 1	0.7	0.9	1.3	0.7	1.1	-1.1
Locomotion velocity, session 2	1.0	1.2	3.4	1.8	-0.5	0.1
Locomotion distance, session 2	0.3	0.5	0.8	0.4	0.7	-0.9
Locomotion velocity, session 3	0.7	0.8	1.8	0.5	1.3	-0.7
Locomotion distance, session 3	0.4	0.4	0.6	0.2	0.7	-0.8
Stereotopy head waving bouts, day 3	1.0	1.1	2.8	-0.7	1.7	-0.3
Stereotopy head waving duration, day 3	0.7	0.8	1.7	-0.7	1.3	-0.5
Locomotion velocity, session 7	0.2	0.2	0.4	-0.3	0.6	0.1
Locomotion distance, session 7	1.1	1.4	2.8	-0.5	1.7	-1.1
Stereotopy head waving bouts, day 7	0.6	0.6	1.3	0.1	-0.7	1.2
Stereotopy head waving duration, day 7	1.2	1.5	2.3	1.5	-1.2	0.8
Locomotion velocity, session 8	0.8	1.0	2.0	-0.3	0.9	-1.4
Locomotion distance, session 8	0.7	1.0	2.2	-0.6	1.5	-0.6
Degree of sensitization distance	0.6	0.6	1.5	-0.4	1.2	-0.2
Degree of sensitization stereotypy	1.6	1.7	2.2	1.1	-1.5	1.4
Conditioned locomotion	0.1	0.2	0.5	0.7	-0.1	-0.1
Cocaine response after cond. corrected	2.4	2.7	3.9	-1.2	2.0	-1.7
Cocaine response after cond. not corrected	1.5	1.7	2.4	-0.9	1.6	-1.3
Cocaine response before conditioning	1.3	1.6	2.5	0.8	-1.6	1.3
Saline control response	1.1	1.4	3.7	1.9	-0.4	-0.7
Bone: connectivity density	0.6	1.0	2.7	1.7	-0.3	0.3
Bone: cortical apparent density	0.3	0.4	0.7	0.6	-0.9	0.0
Bone: cortical area	0.8	1.2	1.6	1.2	-1.0	1.1
Bone: cortical porosity	0.1	0.1	0.2	-0.2	-0.5	0.3
Bone: cortical porosity	0.1	0.1	0.3	0.1	-0.6	0.1
Bone: cortical thickness	1.5	2.5	5.6	2.4	-1.3	-0.4
Bone: cortical thickness	0.4	0.5	1.0	0.7	0.1	-1.0
Bone: cortical tissue density	0.4	0.5	0.9	0.7	-0.9	0.0
Condit. Reinf. active minus inactive responses	0.6	0.7	1.4	1.2	-0.7	0.3
Condit. Reinf. active-inactive response ratio	0.2	0.2	0.4	0.6	-0.6	-0.1
Condit. Reinf. active responses	0.9	1.1	1.5	1.2	-0.9	1.1
Condit. Reinf. inactive responses	0.5	0.6	1.7	0.2	-0.3	1.3
Incentive salience index mean	0.6	0.8	2.1	1.4	-0.4	0.2
Condit. Reinf. lever presses	0.4	0.5	1.6	1.3	-0.1	0.2
Condit. Reinf. active minus inactive responses	0.7	0.9	1.7	-0.5	-0.9	1.3
Condit. Reinf. active-inactive response ratio	1.8	1.9	4.3	-0.8	-0.9	2.1
Condit. Reinf. active responses	0.1	0.2	0.3	0.1	-0.5	0.5
Condit. Reinf. inactive responses	0.7	0.9	2.1	0.5	0.6	-1.4
Condit. Reinf. lever presses	1.0	1.4	1.6	1.3	-1.2	1.0
Condit. Reinf. lever reinforcers received	0.4	0.5	0.8	0.4	-0.9	0.7
Conditioned reinforcement - actives	1.5	1.5	2.2	-1.5	-0.5	1.5
Conditioned reinforcement - inactives	0.9	1.0	1.9	-1.0	-0.1	1.4
Conditioned locomotion	1.2	1.5	3.1	-1.8	1.1	0.4
Patch foraging indifference point 0 sec	0.1	0.2	0.5	0.7	-0.2	-0.1
Patch foraging indifference point AUC	4.1	4.7	6.1	1.9	-2.5	2.1
Delay disc. indifference point, 0s delay	1.9	2.1	4.2	-0.6	2.0	-1.4
Delay disc. indifference point, 16s delay	0.1	0.1	0.1	0.3	0.1	0.4
Delay disc. indifference point, 2s delay	0.3	0.4	0.8	-0.5	0.9	-0.1
Delay disc. indifference point, 24s delay	0.6	0.6	1.1	0.1	0.8	-1.1
Delay disc. indifference point, 4s delay	1.4	1.5	2.2	0.3	1.4	-1.5
Delay disc. indifference point, 8s delay	1.3	1.3	1.8	-0.7	1.3	-1.3
Indifference point function ln k	8.2	11.4	15.8	-2.7	4.0	-3.3
Indifference point function log k	8.2	11.4	15.8	-2.7	4.0	-3.3
Patch foraging total patch changes 0 sec	0.2	0.3	0.6	0.7	-0.0	-0.6
Patch foraging total patch changes 12 sec	4.1	5.3	8.3	2.9	-2.4	1.3
Patch foraging total patch changes 18 sec	0.9	1.1	1.7	0.9	-1.3	0.9
Patch foraging total patch changes 24 sec	3.2	3.9	9.5	3.1	-1.4	0.5
Patch foraging total patch changes 6 sec	0.3	0.5	1.4	1.2	-0.2	-0.1
Patch foraging time to switch 0 sec	0.4	0.6	1.2	0.6	-0.4	1.1
Patch foraging water rate 0 sec	0.4	0.6	0.8	-0.9	0.6	-0.9
Patch foraging water rate 12 sec	3.2	4.9	6.3	-1.7	2.4	-2.5
Patch foraging water rate 18 sec	3.8	5.1	7.7	-0.9	2.6	-2.8
Patch foraging water rate 24 sec	1.7	2.4	2.7	-1.4	1.6	-1.6
Patch foraging water rate 6 sec	2.4	3.5	4.9	-1.2	2.1	-2.2
Seeking ratio, delayed vs. immediate footshock	0.1	0.1	0.1	0.2	0.3	-0.4
Distance traveled before self-admin	2.4	2.5	3.0	1.7	-1.7	1.3
Distance traveled after self-admin	0.9	1.0	1.6	0.7	-1.3	0.9
Extensor digitorum longus weight	2.8	11.2	29.8	5.5	-1.9	0.2
Bone: elastic displacement	0.7	0.8	1.3	-0.8	0.7	-1.1
Bone: elastic work	0.7	0.9	1.6	0.9	0.4	-1.3
Bone: endosteal estimation	0.9	2.0	2.6	-1.6	1.6	0.8
Bone: endosteal perimeter	1.3	2.7	3.7	-1.8	1.0	1.9
Epididymis fat weight	0.3	0.7	1.8	-0.5	1.3	-0.1
Delta time in closed arm before/after self-admin	3.1	3.0	5.5	1.0	1.6	-2.3
Delta time in open arm before/after self-admin	3.2	3.1	4.2	1.3	-2.0	1.9
Diff in mean of infusions in LGA sessions	1.4	1.5	2.4	1.4	-1.6	0.4
Delay discount exponential model param	0.4	0.5	0.9	0.1	-1.0	0.7
Extinction: sum of active levers before priming	2.6	2.6	4.4	2.1	-1.6	0.9
Active lever presses in extinction session 6	3.8	3.7	5.6	1.7	-2.4	1.6
Bone: final force	0.9	1.5	3.5	1.9	-0.8	0.7
Bone: final moment	1.0	1.6	3.5	1.9	-0.8	0.7
Food consumed during 24 hour testing period	0.2	0.2	0.3	-0.1	-0.6	0.6
Glucose	1.5	2.2	4.0	-2.0	1.6	0.1
Heart weight	1.9	2.8	4.4	-1.4	2.1	-1.4
Delay discount hyperbolic model param	0.5	0.5	1.0	0.0	-1.0	0.7
Intermittent access intake day 1-15 change	1.9	1.9	3.0	-0.9	-1.4	1.7
Intermittent access intake escalation	1.5	1.4	2.3	-0.6	-1.3	1.5
Intermittent access intake escalation 2	2.0	2.0	3.1	0.1	-1.7	1.7
Intermitt. access day 1 inactive lever presses	0.9	1.0	2.3	-1.5	0.7	0.4
Intermitt. access day 15 inactive lever presses	0.6	0.7	1.8	0.4	-0.3	1.3
Intermitt. access escalation Index	1.8	1.6	2.5	-0.3	1.6	-1.5
Intermittent access day 1 total infusions	1.6	1.9	4.4	-1.1	2.1	-0.0
Intermittent access day 15 total infusions	1.7	1.9	3.7	-1.9	0.7	1.3
Intermittent access terminal intake (last 3 days)	1.1	1.2	2.9	-0.8	0.2	1.7
Intermittent access total infusions	0.8	0.9	1.1	-1.0	0.8	1.0
Intermittent access day 1 locomotion	2.1	2.2	5.7	-0.5	2.4	-0.8
Intermittent access day 15 total locomotion	0.4	0.4	0.8	-0.5	0.5	0.9
Intermittent access total locomotion	0.8	0.9	1.4	-0.4	1.1	1.2
Intermittent access standard deviation	1.0	1.1	1.5	-1.2	-0.7	1.1
Left kidney weight	0.1	0.2	0.5	0.3	-0.1	0.7
Right kidney weight	0.4	1.1	2.2	0.8	-0.8	1.5
Cocaine induced anxiety	0.6	0.7	1.0	0.5	-0.9	1.0
Post-drug Anxiety	1.7	1.9	2.6	0.8	-1.6	1.5
Baseline Anxiety	0.5	0.6	1.2	1.1	-0.6	-0.3
Tail length	0.5	1.4	2.8	1.7	-1.0	-0.7
Length with tail	1.1	3.9	9.7	3.1	-1.4	-0.0
Length without tail	1.0	2.3	5.8	2.4	-0.9	0.4
Times rat made contact with spout	0.3	0.3	0.8	0.3	0.1	-0.9
Lifetime Intake	0.8	0.9	1.7	-1.0	1.3	0.3
Liver weight, left	0.3	0.5	0.6	-0.8	0.8	-0.6
Liver weight, right	0.5	0.8	1.7	0.2	1.3	-0.9
Locomotor activity	2.0	3.2	4.9	-1.3	1.7	-2.2
Locomotor testing distance	3.2	5.4	8.5	-1.2	2.5	-2.9
Locomotor testing rearing	1.8	2.8	3.7	-1.2	1.8	-1.9
Locomotion in novel chamber	1.1	1.4	2.1	-1.4	0.2	1.4
Locomotion in novel chamber post-restriction	1.1	1.3	3.4	-1.9	0.6	0.4
Fecal boli incidents, locomotor time 1	1.5	1.6	3.3	-0.4	-1.2	1.8
Change in fecal boli incidents, locomotor task	3.4	3.2	4.8	-0.9	2.2	-2.0
Time >=10cm from walls, locomotor time 1	1.4	1.4	2.3	-1.4	0.1	1.5
Bouts of movement, locomotor time 1	1.7	1.8	4.5	0.5	-2.1	0.9
Total resting periods, locomotor time 1	1.7	1.9	4.2	0.5	-2.0	1.1
Rest time, locomotor task time 1	0.5	0.6	1.7	-1.3	0.1	0.0
Distance moved, locomotor task time 1	0.1	0.1	0.2	0.5	0.2	-0.1
Vertical activity count, locomotor time 1	0.4	0.5	0.8	-0.9	0.8	-0.3
Time >=10cm from walls, locomotor time 2	1.2	1.3	2.1	-0.2	-1.3	1.4
Bouts of movement, locomotor time 2	0.9	1.0	1.9	1.4	-1.0	0.2
Total resting periods, locomotor time 2	0.5	0.6	1.0	1.0	-0.8	0.2
Rest time, locomotor task time 2	1.7	1.9	4.2	-2.1	1.2	-0.3
Distance moved, locomotor task time 2	0.5	0.6	1.2	0.8	-1.1	0.3
Vertical activity count, locomotor time 2	0.3	0.3	1.0	-0.2	0.1	-1.0
Light reinforcement 1	0.0	0.0	0.1	-0.1	-0.3	-0.1
Light reinforcement 2	1.7	2.3	5.3	0.1	-1.2	2.3
Bone: marrow area	1.0	2.2	3.0	-1.7	1.7	0.8
Bone: maximum diameter	0.6	1.2	2.7	0.5	-0.8	1.6
Bone: maximum force	1.4	2.3	4.8	2.2	-0.8	1.3
Bone: maximum moment	1.3	2.2	4.6	2.2	-0.7	1.2
Mean time between licks in bursts	1.6	2.3	4.7	0.8	1.2	-2.2
Mean num. licks in bursts	0.1	0.2	0.4	-0.3	0.2	-0.6
Cd content in liver	0.7	0.7	1.9	-1.4	0.0	0.5
Co content in liver	2.1	2.4	3.6	-1.6	1.1	-1.9
Cu content in liver	0.3	0.4	1.0	0.4	0.2	-1.0
Fe content in liver	0.1	0.1	0.3	-0.1	-0.4	0.5
K content in liver	0.6	0.6	1.4	1.2	-0.2	0.6
Mg content in liver	0.2	0.2	0.4	0.7	0.4	0.2
Mn content in liver	1.9	2.2	3.5	1.9	-1.5	1.0
Na content in liver	0.8	0.8	1.0	0.8	-0.8	1.0
Rb content in liver	1.6	2.0	2.9	-1.3	1.7	-1.1
Se content in liver	1.8	2.2	3.8	0.6	-1.5	2.0
Sr content in liver	3.9	3.6	6.2	2.5	-1.9	0.9
Zn content in liver	2.2	2.5	4.5	2.1	-1.3	1.1
Bone: minimum diameter	0.6	1.0	1.2	-0.9	1.1	1.1
Time in familiar zone, hab. session 1	0.1	0.1	0.2	0.4	0.4	-0.2
Time in novel zone, hab. session 1	1.1	1.1	1.8	-1.3	0.9	-0.9
Total zone transitions, hab. session 1	0.1	0.1	0.2	0.4	-0.3	-0.1
Total locomotion distance, hab. session 1	0.1	0.2	0.2	-0.4	0.5	0.5
Locomotion velocity, hab. session 1	0.1	0.1	0.3	0.2	-0.0	0.6
Time in familiar zone, hab. session 2	0.5	0.5	1.3	-0.2	0.6	-1.1
Time in novel zone, hab. session 2	0.1	0.1	0.2	0.4	-0.1	0.3
Total zone transitions, hab. session 2	0.8	1.0	2.2	1.5	0.5	-0.8
Total locomotion distance, hab. session 2	0.3	0.4	0.9	0.4	1.0	-0.5
Locomotion velocity, hab. session 2	0.2	0.3	0.7	0.2	0.9	-0.2
Novel to familiar place preference ratio	1.8	1.9	2.4	1.5	-1.4	1.2
Novelty place preference	1.4	1.4	1.5	1.2	-1.2	1.1
Time in novel zone, NPP test	1.1	1.1	1.5	1.2	-1.1	0.9
Total zone transitions, NPP test	0.4	0.6	1.4	1.2	-0.0	-0.6
Total locomotion distance, NPP test	0.3	0.4	0.8	0.1	0.9	-0.7
Locomotion velocity, NPP test	0.2	0.2	0.4	-0.0	0.6	-0.5
Intraocular pressure	0.4	0.6	1.4	-0.2	-1.2	0.6
Delta distance traveled before/after self-admin	0.6	0.7	0.8	-0.8	0.8	-0.9
Delta ambulatory time before/after self-admin	1.1	1.2	1.4	-1.1	1.0	-1.2
Parametrial fat weight	0.9	1.8	3.0	-1.7	1.4	0.6
Pavlov. Cond. lever latency	0.6	0.7	1.8	-1.4	0.3	-0.5
Pavlov. Cond. magazine entry latency	1.2	1.5	1.9	1.4	-0.9	1.3
Pavlov. Cond. change in total contacts	1.5	1.6	3.1	0.6	-1.2	1.8
Pavlov. Cond. index score	0.8	1.1	1.2	1.0	-1.0	1.1
Pavlov. Cond. latency score	0.4	0.5	0.9	0.9	-0.5	0.7
Pavlov. Cond. lever contacts	0.2	0.2	0.5	0.7	-0.0	0.3
Pavlov. Cond. magazine entry number	1.6	2.0	2.7	-1.0	1.6	-1.5
Pavlov. Cond. intertrial magazine entries	0.9	1.0	1.9	0.1	-1.4	1.1
Pavlov. Cond. lever-magazine prob. diff.	1.1	1.4	1.6	1.2	-1.1	1.3
Pavlov. Cond. response bias	1.2	1.4	1.7	1.1	-1.2	1.3
Pavlov. Cond. lever latency	0.3	0.4	0.8	-0.9	0.5	-0.5
Pavlov. Cond. magazine entry latency	2.8	3.3	5.7	2.4	-1.9	0.8
Pavlov. Cond. change in total contacts	2.4	3.3	4.1	1.6	-2.0	1.8
Pavlov. Cond. index score	2.5	3.2	4.1	2.0	-1.9	1.4
Pavlov. Cond. latency score	2.2	2.8	3.6	1.9	-1.7	1.4
Pavlov. Cond. lever contacts	0.5	0.7	1.0	0.8	-1.0	0.7
Pavlov. Cond. magazine entry number	5.0	6.1	10.1	-3.2	2.5	-1.4
Pavlov. Cond. intertrial magazine entries	0.6	0.8	2.2	-1.5	0.3	0.3
Pavlov. Cond. lever-magazine prob. diff.	2.6	3.3	4.7	2.2	-1.9	1.3
Pavlov. Cond. response bias	1.4	1.9	2.7	1.7	-1.5	0.9
Time in closed arm before self-admin	0.7	0.8	1.8	0.1	-0.9	1.3
Time in closed arm after self-admin	1.1	1.2	1.8	-0.8	1.4	-1.0
Time in open arm before self-admin	4.3	4.7	7.6	-1.1	2.3	-2.8
Time in open arm after self-admin	0.1	0.1	0.2	0.1	-0.4	-0.3
Bone: periosteal estimation	0.4	0.8	2.2	-0.1	0.2	1.5
Bone: periosteal perimeter	0.5	0.9	2.6	0.1	-0.3	1.6
Bone: post-yield work	1.0	1.4	4.0	-0.5	0.2	2.0
Progressive ratio test 1 active lever presses	1.2	1.2	3.1	-1.8	0.6	0.3
Progressive ratio test 1 breakpoint	1.3	1.3	3.4	-1.9	0.6	0.4
Progressive ratio test 1 inactive lever presses	0.4	0.4	0.7	-0.0	0.9	-0.7
Progressive ratio test 2 active lever presses	1.1	1.2	2.3	-1.5	0.4	1.1
Progressive ratio test 2 breakpoint	1.5	1.7	3.7	-1.9	0.4	1.1
Progressive ratio test 2 inactive lever presses	0.7	0.8	1.4	-1.0	0.4	1.2
Incentive Sensitization - Responses	0.5	0.5	1.2	0.2	-0.4	1.1
Incentive Sensitization - Breakpoint	0.5	0.5	1.3	0.1	-0.3	1.2
Sum of active levers in priming session hrs 5-6	6.3	6.1	10.0	1.2	-3.2	2.6
Progressive ratio	0.2	0.2	0.5	0.4	-0.2	0.7
Food seeking constrained by brief footshock	0.5	0.6	1.1	-0.3	0.8	-1.0
Seeking ratio, punishment vs. effort	1.2	1.4	2.8	-0.6	1.1	-1.7
Retroperitoneal fat weight	1.7	5.7	8.5	-2.9	2.8	-0.7
Reaction time number correct	0.4	0.5	1.0	1.0	-0.2	-0.8
Reaction time mean minus median	3.2	4.3	6.5	0.6	-2.5	2.4
Reaction time mean minus median AUC	1.6	2.1	4.0	0.4	-2.0	1.5
Reaction time num false alarms	1.8	2.4	4.4	-0.8	1.5	-2.1
Reaction time num false alarms AUC	1.4	2.0	4.5	-0.4	1.1	-2.1
Reaction time trials correct on left	0.4	0.5	1.0	1.0	-0.2	-0.8
Reaction time trials on left	0.4	0.5	1.0	1.0	-0.3	-0.8
Reaction time mean	1.2	1.6	2.4	-0.2	-1.5	1.6
Reaction time mean AUC	1.1	1.5	2.4	-0.2	-1.5	1.5
Median of all reaction times	0.5	0.7	1.1	-0.1	-1.0	1.1
Reaction time omissions	0.3	0.4	1.1	-0.0	-1.1	0.3
Reaction time false alarm rate	1.1	1.6	2.3	-0.9	1.3	-1.5
Reaction time premature initiation rate	2.3	3.1	6.9	2.6	0.4	-1.5
Reaction time premature initiations	2.9	4.1	9.3	3.1	-0.0	-1.7
Std. dev. reaction times	1.7	2.4	4.1	-0.2	-2.0	1.8
Reaction time trials completed	0.4	0.5	1.0	1.0	-0.3	-0.8
Reaction time trials AUC	0.3	0.5	0.8	0.9	-0.0	-0.9
Run reversals in cocaine runway, females	3.0	2.9	4.1	0.8	2.0	-2.0
Run reversals in cocaine runway, males	0.3	0.3	0.7	-0.8	0.3	-0.3
Latency to leave start box in cocaine runway	0.4	0.4	0.9	-0.6	0.9	0.1
Latency to leave start box in cocaine runway, F	0.0	0.0	0.1	0.0	0.1	0.3
Latency to leave start box in cocaine runway, M	1.8	1.7	3.5	-1.9	1.3	-0.1
Std. dev. time between licks in bursts	1.7	2.0	3.4	-0.5	1.5	-1.9
Total sessions with >9 infusions	1.9	2.1	4.3	-1.3	2.1	-0.8
Short access day 1 total inactive lever presses	1.4	1.5	3.0	-1.1	1.7	-0.7
Short access day 10 total inactive lever presses	2.9	3.2	3.9	-1.8	2.0	-1.6
Short access day 1 total infusions	1.4	1.5	3.1	-0.9	1.8	-0.8
Short access day 10 total infusions	1.0	1.1	3.1	-0.5	1.8	-0.3
Short access total infusions	1.5	1.6	3.7	-0.7	1.9	-0.8
Short access day 1 locomotion	1.0	1.1	2.7	0.2	1.6	-0.7
Short access day 10 total locomotion	0.4	0.5	1.4	0.1	1.2	-0.2
Short access total locomotion	0.9	1.0	2.5	0.4	1.6	-0.6
One hour access (0.3 mA shock)	1.9	2.2	4.6	-2.1	1.2	0.7
Compulsive drug intake	2.1	2.2	4.9	1.2	0.4	-2.2
One hour access (shock baseline)	3.2	3.7	6.4	-2.5	0.1	2.2
Social response proportion	0.1	0.1	0.2	0.4	0.1	-0.4
Social responses	0.1	0.1	0.2	0.2	-0.3	-0.5
Social time	0.1	0.2	0.5	0.1	0.0	-0.7
Soleus weight	1.6	4.7	9.0	-3.0	2.1	-0.9
Bone: stiffness	1.1	1.7	2.5	1.2	-1.1	1.6
Tibialis anterior weight	5.1	17.3	38.4	6.2	-3.5	1.3
Time to tail flick, vehicle, before self-admin	0.3	0.3	0.5	0.7	0.1	0.6
Time to tail flick, vehicle, after self-admin	0.7	0.8	1.0	0.5	1.0	-1.0
Time to tail flick, test, before self-admin	1.6	1.5	3.0	0.5	1.7	-1.2
Time to tail flick, test, after self-admin	0.0	0.0	0.1	-0.3	-0.0	0.0
Delta time to tail flick, vehicle, before/after SA	0.4	0.4	0.8	-0.1	0.6	-0.9
Delta time to tail flick, test, before/after SA	1.6	1.4	3.2	-0.1	-1.8	1.1
Tibia length	2.5	7.1	8.9	2.1	-2.8	3.0
Ambulatory time before self-admin	3.6	3.7	4.8	1.6	-2.2	1.9
Ambulatory time after self-admin	0.9	1.0	1.6	0.6	-1.1	1.3
Bone: tissue strength	0.0	0.0	0.1	-0.1	0.0	-0.2
Total heroin consumption	2.8	3.3	4.8	2.2	-2.2	0.7
Bone: trabecular number	0.3	0.5	1.1	1.0	-0.4	0.6
Bone: trabecular spacing	0.6	0.7	1.5	-0.6	0.6	-1.2
Bone: trabecular thickness	0.5	0.5	1.3	-0.4	-0.4	1.1
Bone: trabecular tissue density	1.9	2.7	7.3	-2.7	0.8	-0.4
Water consumed over 24 hours	0.3	0.4	0.8	0.9	-0.4	-0.4
Number of responses in last shaping day	0.7	0.7	1.4	-0.1	0.9	-1.2