Hub : Traits

Bone: stiffness

Tags: Physiology · Bone

Project: r01_doug_adams

429 significantly associated models · 66 unique genes

Significant Loci

# chr p0 p1 # assoc genes # joint models best TWAS P best SNP P cond SNP P % var exp joint genes
1 7 16845355 16970279 1 1 5.9e-49 NaN NA NA NA
2 7 128200675 132492191 65 10 1.2e-08 3e-08 1 100 Slc48a1 Tmem106c Tuba1b Fkbp11 Hdac7 Dip2b Bcdin3d Asic1 Prkag1 Fkbp11

p0: physical position of the start of the locus. p1: physical position of the end of the locus. # joint models: number of models selected by step-wise conditional analysis.

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
BMI with tail 5.1 47 0 0.0 1.00 4.4e-207 Mettl7a Asb8 Slc11a2 Tuba1c Senp1 Letmd1 Zfp641 Olr1106 Galnt6 Faim2 Prph Cers5 Ccnt1 Slc48a1 Tmem106c Tuba1b Cacnb3 Adcy6 Fkbp11 Tmbim6 Hdac7 Dip2b Nckap5l Pfkm Bcdin3d Ccdc65 Asic1 Lima1 Rnd1 Rapgef3 Ddx23 Kansl2 Atf1 Kmt2d Smarcd1 NA Smagp NA NA NA NA NA Prkag1 NA Olr1877 Olr1108 Fkbp11
BMI without tail 106.7 1 1 9.1 0.00 1.0e+00 NA
Body weight 5.9 66 35 318.2 0.99 0.0e+00 Mettl7a Asb8 Slc11a2 Csrnp2 Tuba1c Senp1 Letmd1 Tmprss12 Zfp641 Olr1106 Galnt6 Faim2 Aqp5 Spats2 Prpf40b Prph Cers5 Ccnt1 Slc48a1 Tmem106c Tuba1b Dnajc22 Dhh Cacnb3 Rhebl1 Adcy6 Fkbp11 Mcrs1 Tmbim6 Hdac7 Dip2b Fmnl3 Gpd1 Nckap5l Kcnh3 Pfkm Bcdin3d Ccdc65 Asic1 Lima1 Rnd1 Rapgef3 C1ql4 Ddx23 Kansl2 Atf1 Kmt2d Smarcd1 NA Smagp NA NA NA NA NA NA NA Larp4 NA NA NA Prkag1 NA Olr1877 Olr1108 Fkbp11
Epididymis fat weight 87.6 1 1 9.1 0.00 1.0e+00 NA
Heart weight 11.4 1 0 0.0 0.00 1.0e+00 NA
Left kidney weight 37.5 1 1 9.1 0.00 1.0e+00 NA
Right kidney weight 41.9 1 1 9.1 0.00 1.0e+00 NA
Tail length 58.1 1 1 9.1 0.00 1.0e+00 NA
Length without tail 8.2 42 1 9.1 0.90 7.3e-94 Asb8 Tuba1c Senp1 Zfp641 Olr1106 Faim2 Spats2 Prpf40b Prph Ccnt1 Slc48a1 Tmem106c Tuba1b Dnajc22 Dhh Cacnb3 Rhebl1 Adcy6 Fkbp11 Tmbim6 Hdac7 Fmnl3 Nckap5l Kcnh3 Pfkm Bcdin3d Ccdc65 Asic1 Rnd1 Rapgef3 Ddx23 Kansl2 Kmt2d NA NA NA NA NA Prkag1 Olr1877 Olr1108 Fkbp11
Liver weight, left 23.6 1 1 9.1 0.00 1.0e+00 NA
Liver weight, right 9.6 1 0 0.0 0.00 1.0e+00 NA
Parametrial fat weight 26.4 1 1 9.1 0.00 1.0e+00 NA
Intraocular pressure 14.4 4 1 9.1 -0.96 2.8e-03 Tmem106c Hdac7 Pfkm NA
Extensor digitorum longus weight 4.8 64 4 36.4 0.93 5.8e-150 Mettl7a Asb8 Slc11a2 Tuba1c Senp1 Letmd1 Tmprss12 Zfp641 Olr1106 Galnt6 Faim2 Aqp5 Spats2 Prpf40b Prph Cers5 Ccnt1 Slc48a1 Tmem106c Tuba1b Dnajc22 Dhh Cacnb3 Rhebl1 Adcy6 Fkbp11 Mcrs1 Tmbim6 Hdac7 Dip2b Gpd1 Nckap5l Kcnh3 Pfkm Bcdin3d Ccdc65 Asic1 Lima1 Rnd1 Rapgef3 C1ql4 Ddx23 Kansl2 Atf1 Kmt2d Smarcd1 NA Smagp NA NA NA NA NA NA NA Larp4 NA NA NA Prkag1 NA Olr1877 Olr1108 Fkbp11
Soleus weight 13.7 1 1 9.1 0.00 1.0e+00 NA
Tibialis anterior weight 8.8 6 1 9.1 0.15 4.6e-01 Mettl7a Slc11a2 Letmd1 Dip2b Smagp NA
Tibia length 7.2 50 4 36.4 0.99 6.6e-263 Mettl7a Asb8 Slc11a2 Csrnp2 Tuba1c Senp1 Zfp641 Olr1106 Faim2 Spats2 Prpf40b Prph Ccnt1 Slc48a1 Tmem106c Tuba1b Dnajc22 Dhh Cacnb3 Rhebl1 Adcy6 Fkbp11 Tmbim6 Hdac7 Dip2b Fmnl3 Nckap5l Kcnh3 Pfkm Bcdin3d Ccdc65 Asic1 Lima1 Rnd1 Rapgef3 Ddx23 Kansl2 Atf1 Kmt2d NA NA NA NA NA NA Prkag1 NA Olr1877 Olr1108 Fkbp11
Number of licking bursts 155.0 1 1 9.1 0.00 1.0e+00 NA
Food consumed during 24 hour testing period 17.5 1 0 0.0 0.00 1.0e+00 NA
Times rat made contact with spout 75.1 1 1 9.1 0.00 1.0e+00 NA
Mean time between licks in bursts 54.9 1 1 9.1 0.00 1.0e+00 NA
Mean num. licks in bursts 164.2 1 1 9.1 0.00 1.0e+00 NA
Std. dev. time between licks in bursts 177.7 1 1 9.1 0.00 1.0e+00 NA
Indifference point 0 sec 18.7 1 1 9.1 0.00 1.0e+00 NA
Indifference point AUC 42.1 1 1 9.1 0.00 1.0e+00 NA
Delay discounting total patch changes 0 sec 17.7 1 1 9.1 0.00 1.0e+00 NA
Delay discounting total patch changes 12 sec 102.7 1 1 9.1 0.00 1.0e+00 NA
Delay discounting total patch changes 18 sec 175.3 1 1 9.1 0.00 1.0e+00 NA
Delay discounting total patch changes 24 sec 28.3 1 1 9.1 0.00 1.0e+00 NA
Delay discounting total patch changes 6 sec 98.5 1 1 9.1 0.00 1.0e+00 NA
Delay discounting water rate 0 sec 11.8 1 0 0.0 0.00 1.0e+00 NA
Delay discounting water rate 12 sec 44.2 1 1 9.1 0.00 1.0e+00 NA
Delay discounting water rate 24 sec 62.7 1 1 9.1 0.00 1.0e+00 NA
Delay discounting water rate 6 sec 44.2 1 1 9.1 0.00 1.0e+00 NA
Locomotor testing distance 11.5 1 0 0.0 0.00 1.0e+00 NA
Locomotor testing rearing 16.8 1 1 9.1 0.00 1.0e+00 NA
Light reinforcement 1 54.8 1 1 9.1 0.00 1.0e+00 NA
Reaction time num false alarms 56.4 1 1 9.1 0.00 1.0e+00 NA
Reaction time num false alarms AUC 79.5 1 1 9.1 0.00 1.0e+00 NA
Reaction time mean 41.3 1 1 9.1 0.00 1.0e+00 NA
Reaction time mean AUC 58.0 1 1 9.1 0.00 1.0e+00 NA
Median of all reaction times 51.2 1 1 9.1 0.00 1.0e+00 NA
Reaction time omissions 11.5 5 0 0.0 -1.00 2.9e-07 Slc48a1 Tuba1b Pfkm Olr1877 Fkbp11
Reaction time false alarm rate 63.4 1 1 9.1 0.00 1.0e+00 NA
Reaction time premature initiation rate 32.1 1 1 9.1 0.00 1.0e+00 NA
Reaction time premature initiations 34.3 1 1 9.1 0.00 1.0e+00 NA
Std. dev. reaction times 27.0 1 1 9.1 0.00 1.0e+00 NA
Reaction time trials AUC 15.6 1 0 0.0 0.00 1.0e+00 NA
Social responses 74.3 1 1 9.1 0.00 1.0e+00 NA
Cocaine response after cond. corrected 78.0 1 1 9.1 0.00 1.0e+00 NA
Cocaine response after cond. not corrected 102.3 1 1 9.1 0.00 1.0e+00 NA
Cocaine response before conditioning 28.6 1 1 9.1 0.00 1.0e+00 NA
Saline control response 50.6 1 1 9.1 0.00 1.0e+00 NA
Condit. Reinf. active minus inactive responses 29.4 1 1 9.1 0.00 1.0e+00 NA
Condit. Reinf. active-inactive response ratio 68.7 1 1 9.1 0.00 1.0e+00 NA
Condit. Reinf. active responses 11.1 1 0 0.0 0.00 1.0e+00 NA
Condit. Reinf. inactive responses 20.6 1 0 0.0 0.00 1.0e+00 NA
Pavlov. Cond. lever latency 36.3 1 1 9.1 0.00 1.0e+00 NA
Pavlov. Cond. magazine entry latency 104.9 1 1 9.1 0.00 1.0e+00 NA
Pavlov. Cond. change in total contacts 130.1 1 1 9.1 0.00 1.0e+00 NA
Pavlov. Cond. index score 62.2 1 1 9.1 0.00 1.0e+00 NA
Pavlov. Cond. latency score 67.1 1 1 9.1 0.00 1.0e+00 NA
Pavlov. Cond. lever contacts 29.4 1 1 9.1 0.00 1.0e+00 NA
Pavlov. Cond. magazine entry number 150.0 1 1 9.1 0.00 1.0e+00 NA
Pavlov. Cond. intertrial magazine entries 63.9 1 1 9.1 0.00 1.0e+00 NA
Pavlov. Cond. lever-magazine prob. diff. 55.1 1 1 9.1 0.00 1.0e+00 NA
Pavlov. Cond. response bias 51.3 1 1 9.1 0.00 1.0e+00 NA
Conditioned reinforcement - actives 18.5 1 0 0.0 0.00 1.0e+00 NA
Intermittent access intake day 1-15 change 61.5 1 1 9.1 0.00 1.0e+00 NA
Intermittent access intake escalation 82.5 1 1 9.1 0.00 1.0e+00 NA
Intermittent access intake escalation 2 42.5 1 1 9.1 0.00 1.0e+00 NA
Intermitt. access day 1 inactive lever presses 30.6 1 1 9.1 0.00 1.0e+00 NA
Intermittent access day 1 total infusions 52.9 1 1 9.1 0.00 1.0e+00 NA
Intermittent access day 1 locomotion 27.1 1 1 9.1 0.00 1.0e+00 NA
Post-drug Anxiety 20.6 1 0 0.0 0.00 1.0e+00 NA
Progressive ratio test 2 breakpoint 38.7 1 1 9.1 0.00 1.0e+00 NA
Short access day 10 total infusions 24.0 1 1 9.1 0.00 1.0e+00 NA
Short access day 1 locomotion 17.2 1 0 0.0 0.00 1.0e+00 NA
Compulsive drug intake 45.4 1 1 9.1 0.00 1.0e+00 NA
Context. condit. distance diff. score 149.8 1 1 9.1 0.00 1.0e+00 NA
Locomotion velocity, session 1 117.8 1 1 9.1 0.00 1.0e+00 NA
Locomotion distance, session 1 374.7 1 1 9.1 0.00 1.0e+00 NA
Locomotion velocity, session 2 82.2 1 1 9.1 0.00 1.0e+00 NA
Locomotion distance, session 2 776.0 1 1 9.1 0.00 1.0e+00 NA
Locomotion velocity, session 3 116.1 1 1 9.1 0.00 1.0e+00 NA
Locomotion distance, session 3 82.4 1 1 9.1 0.00 1.0e+00 NA
Stereotopy head waving duration, day 3 25.6 1 1 9.1 0.00 1.0e+00 NA
Locomotion velocity, session 7 66.3 1 1 9.1 0.00 1.0e+00 NA
Locomotion distance, session 7 31.8 1 1 9.1 0.00 1.0e+00 NA
Stereotopy head waving bouts, day 7 42.6 1 1 9.1 0.00 1.0e+00 NA
Stereotopy head waving duration, day 7 63.4 1 1 9.1 0.00 1.0e+00 NA
Locomotion distance, session 8 102.8 1 1 9.1 0.00 1.0e+00 NA
Degree of sensitization distance 140.6 1 1 9.1 0.00 1.0e+00 NA
Degree of sensitization stereotypy 37.5 1 1 9.1 0.00 1.0e+00 NA
Condit. Reinf. active-inactive response ratio 65.1 1 1 9.1 0.00 1.0e+00 NA
Condit. Reinf. active responses 20.0 1 0 0.0 0.00 1.0e+00 NA
Condit. Reinf. inactive responses 17.2 1 0 0.0 0.00 1.0e+00 NA
Incentive salience index mean 15.6 1 0 0.0 0.00 1.0e+00 NA
Condit. Reinf. lever presses 35.1 1 1 9.1 0.00 1.0e+00 NA
Time in familiar zone, hab. session 1 16.4 1 0 0.0 0.00 1.0e+00 NA
Time in novel zone, hab. session 1 17.4 1 0 0.0 0.00 1.0e+00 NA
Total zone transitions, hab. session 1 415.6 1 1 9.1 0.00 1.0e+00 NA
Total locomotion distance, hab. session 1 171.4 1 1 9.1 0.00 1.0e+00 NA
Locomotion velocity, hab. session 1 218.6 1 1 9.1 0.00 1.0e+00 NA
Time in familiar zone, hab. session 2 48.9 1 1 9.1 0.00 1.0e+00 NA
Time in novel zone, hab. session 2 58.4 1 1 9.1 0.00 1.0e+00 NA
Total zone transitions, hab. session 2 256.1 1 1 9.1 0.00 1.0e+00 NA
Total locomotion distance, hab. session 2 133.1 1 1 9.1 0.00 1.0e+00 NA
Locomotion velocity, hab. session 2 139.4 1 1 9.1 0.00 1.0e+00 NA
Total zone transitions, NPP test 228.8 1 1 9.1 0.00 1.0e+00 NA
Total locomotion distance, NPP test 163.4 1 1 9.1 0.00 1.0e+00 NA
Locomotion velocity, NPP test 195.9 1 1 9.1 0.00 1.0e+00 NA
Pavlov. Cond. magazine entry latency 56.4 1 1 9.1 0.00 1.0e+00 NA
Pavlov. Cond. change in total contacts 40.1 1 1 9.1 0.00 1.0e+00 NA
Pavlov. Cond. index score 51.9 1 1 9.1 0.00 1.0e+00 NA
Pavlov. Cond. latency score 16.6 1 0 0.0 0.00 1.0e+00 NA
Pavlov. Cond. lever contacts 16.1 1 0 0.0 0.00 1.0e+00 NA
Pavlov. Cond. magazine entry number 61.6 1 1 9.1 0.00 1.0e+00 NA
Pavlov. Cond. lever-magazine prob. diff. 50.5 1 1 9.1 0.00 1.0e+00 NA
Pavlov. Cond. response bias 52.4 1 1 9.1 0.00 1.0e+00 NA
Bone: apparent density 10.7 44 1 9.1 0.96 4.4e-152 Asb8 Tuba1c Senp1 Zfp641 Olr1106 Faim2 Spats2 Prpf40b Prph Ccnt1 Slc48a1 Tmem106c Tuba1b Dnajc22 Dhh Cacnb3 Rhebl1 Adcy6 Fkbp11 Tmbim6 Hdac7 Fmnl3 Nckap5l Kcnh3 Pfkm Bcdin3d Ccdc65 Asic1 Lima1 Rnd1 Rapgef3 Ddx23 Kansl2 Kmt2d NA NA NA NA NA Prkag1 NA Olr1877 Olr1108 Fkbp11
Bone surface 11.5 65 1 9.1 1.00 0.0e+00 Mettl7a Asb8 Slc11a2 Csrnp2 Tuba1c Senp1 Letmd1 Tmprss12 Zfp641 Olr1106 Faim2 Aqp5 Spats2 Prpf40b Prph Cers5 Ccnt1 Slc48a1 Tmem106c Tuba1b Dnajc22 Dhh Cacnb3 Rhebl1 Adcy6 Fkbp11 Mcrs1 Tmbim6 Hdac7 Dip2b Fmnl3 Gpd1 Nckap5l Kcnh3 Pfkm Bcdin3d Ccdc65 Asic1 Lima1 Rnd1 Rapgef3 C1ql4 Ddx23 Kansl2 Atf1 Kmt2d Smarcd1 NA Smagp NA NA NA NA NA NA NA Larp4 NA NA NA Prkag1 NA Olr1877 Olr1108 Fkbp11
Bone volume 9.7 56 1 9.1 1.00 0.0e+00 Mettl7a Asb8 Slc11a2 Csrnp2 Tuba1c Senp1 Olr1106 Faim2 Aqp5 Spats2 Prpf40b Prph Cers5 Ccnt1 Slc48a1 Tmem106c Tuba1b Dnajc22 Dhh Cacnb3 Rhebl1 Adcy6 Fkbp11 Mcrs1 Tmbim6 Hdac7 Dip2b Fmnl3 Gpd1 Nckap5l Kcnh3 Pfkm Bcdin3d Ccdc65 Asic1 Lima1 Rnd1 Rapgef3 Ddx23 Kansl2 Atf1 Kmt2d Smarcd1 NA NA NA NA NA NA NA NA NA Prkag1 NA Olr1877 Fkbp11
Bone: connectivity density 9.6 2 0 0.0 0.00 1.0e+00 Ccdc65 Prkag1
Bone: cortical area 10.5 33 0 0.0 1.00 1.7e-203 Asb8 Tuba1c Senp1 Zfp641 Olr1106 Spats2 Prph Ccnt1 Slc48a1 Tmem106c Tuba1b Dnajc22 Dhh Cacnb3 Rhebl1 Adcy6 Fkbp11 Hdac7 Pfkm Ccdc65 Rnd1 Rapgef3 Ddx23 Kansl2 Kmt2d NA NA NA NA Prkag1 Olr1877 Olr1108 Fkbp11
Bone: cortical porosity 109.3 1 1 9.1 0.00 1.0e+00 NA
Bone: cortical porosity 91.2 1 1 9.1 0.00 1.0e+00 NA
Bone: cortical thickness 17.9 1 0 0.0 0.00 1.0e+00 NA
Bone: elastic displacement 28.2 1 1 9.1 0.00 1.0e+00 NA
Bone: endosteal estimation 7.9 63 1 9.1 1.00 0.0e+00 Mettl7a Asb8 Slc11a2 Csrnp2 Tuba1c Senp1 Letmd1 Tmprss12 Zfp641 Faim2 Spats2 Prpf40b Prph Cers5 Ccnt1 Slc48a1 Tmem106c Tuba1b Dnajc22 Dhh Cacnb3 Rhebl1 Adcy6 Fkbp11 Mcrs1 Tmbim6 Hdac7 Dip2b Fmnl3 Gpd1 Nckap5l Kcnh3 Pfkm Bcdin3d Ccdc65 Asic1 Lima1 Rnd1 Rapgef3 C1ql4 Ddx23 Kansl2 Atf1 Kmt2d Smarcd1 NA Smagp NA NA NA NA NA NA NA Larp4 NA NA NA Prkag1 NA Olr1877 Olr1108 Fkbp11
Bone: endosteal perimeter 7.5 40 0 0.0 1.00 2.4e-118 Mettl7a Asb8 Slc11a2 Csrnp2 Tuba1c Senp1 Zfp641 Faim2 Prph Cers5 Slc48a1 Tmem106c Tuba1b Cacnb3 Adcy6 Fkbp11 Tmbim6 Hdac7 Dip2b Gpd1 Nckap5l Pfkm Bcdin3d Ccdc65 Asic1 Lima1 Rapgef3 Kansl2 Atf1 Kmt2d Smarcd1 NA NA NA NA NA Prkag1 NA Olr1108 Fkbp11
Bone: final force 10.7 66 1 9.1 1.00 0.0e+00 Mettl7a Asb8 Slc11a2 Csrnp2 Tuba1c Senp1 Letmd1 Tmprss12 Zfp641 Olr1106 Galnt6 Faim2 Aqp5 Spats2 Prpf40b Prph Cers5 Ccnt1 Slc48a1 Tmem106c Tuba1b Dnajc22 Dhh Cacnb3 Rhebl1 Adcy6 Fkbp11 Mcrs1 Tmbim6 Hdac7 Dip2b Fmnl3 Gpd1 Nckap5l Kcnh3 Pfkm Bcdin3d Ccdc65 Asic1 Lima1 Rnd1 Rapgef3 C1ql4 Ddx23 Kansl2 Atf1 Kmt2d Smarcd1 NA Smagp NA NA NA NA NA NA NA Larp4 NA NA NA Prkag1 NA Olr1877 Olr1108 Fkbp11
Bone: final moment 11.4 66 1 9.1 1.00 0.0e+00 Mettl7a Asb8 Slc11a2 Csrnp2 Tuba1c Senp1 Letmd1 Tmprss12 Zfp641 Olr1106 Galnt6 Faim2 Aqp5 Spats2 Prpf40b Prph Cers5 Ccnt1 Slc48a1 Tmem106c Tuba1b Dnajc22 Dhh Cacnb3 Rhebl1 Adcy6 Fkbp11 Mcrs1 Tmbim6 Hdac7 Dip2b Fmnl3 Gpd1 Nckap5l Kcnh3 Pfkm Bcdin3d Ccdc65 Asic1 Lima1 Rnd1 Rapgef3 C1ql4 Ddx23 Kansl2 Atf1 Kmt2d Smarcd1 NA Smagp NA NA NA NA NA NA NA Larp4 NA NA NA Prkag1 NA Olr1877 Olr1108 Fkbp11
Bone: marrow area 7.8 62 1 9.1 1.00 0.0e+00 Mettl7a Asb8 Slc11a2 Csrnp2 Tuba1c Senp1 Letmd1 Tmprss12 Zfp641 Faim2 Spats2 Prpf40b Prph Cers5 Ccnt1 Slc48a1 Tmem106c Tuba1b Dnajc22 Dhh Cacnb3 Rhebl1 Adcy6 Fkbp11 Mcrs1 Tmbim6 Hdac7 Dip2b Fmnl3 Gpd1 Nckap5l Kcnh3 Pfkm Bcdin3d Ccdc65 Asic1 Lima1 Rnd1 Rapgef3 Ddx23 Kansl2 Atf1 Kmt2d Smarcd1 NA Smagp NA NA NA NA NA NA NA Larp4 NA NA NA Prkag1 NA Olr1877 Olr1108 Fkbp11
Bone: maximum force 14.4 66 32 290.9 1.00 0.0e+00 Mettl7a Asb8 Slc11a2 Csrnp2 Tuba1c Senp1 Letmd1 Tmprss12 Zfp641 Olr1106 Galnt6 Faim2 Aqp5 Spats2 Prpf40b Prph Cers5 Ccnt1 Slc48a1 Tmem106c Tuba1b Dnajc22 Dhh Cacnb3 Rhebl1 Adcy6 Fkbp11 Mcrs1 Tmbim6 Hdac7 Dip2b Fmnl3 Gpd1 Nckap5l Kcnh3 Pfkm Bcdin3d Ccdc65 Asic1 Lima1 Rnd1 Rapgef3 C1ql4 Ddx23 Kansl2 Atf1 Kmt2d Smarcd1 NA Smagp NA NA NA NA NA NA NA Larp4 NA NA NA Prkag1 NA Olr1877 Olr1108 Fkbp11
Bone: maximum moment 15.3 66 48 436.4 1.00 0.0e+00 Mettl7a Asb8 Slc11a2 Csrnp2 Tuba1c Senp1 Letmd1 Tmprss12 Zfp641 Olr1106 Galnt6 Faim2 Aqp5 Spats2 Prpf40b Prph Cers5 Ccnt1 Slc48a1 Tmem106c Tuba1b Dnajc22 Dhh Cacnb3 Rhebl1 Adcy6 Fkbp11 Mcrs1 Tmbim6 Hdac7 Dip2b Fmnl3 Gpd1 Nckap5l Kcnh3 Pfkm Bcdin3d Ccdc65 Asic1 Lima1 Rnd1 Rapgef3 C1ql4 Ddx23 Kansl2 Atf1 Kmt2d Smarcd1 NA Smagp NA NA NA NA NA NA NA Larp4 NA NA NA Prkag1 NA Olr1877 Olr1108 Fkbp11
Bone: minimum diameter 9.4 64 1 9.1 1.00 0.0e+00 Mettl7a Asb8 Slc11a2 Csrnp2 Tuba1c Senp1 Letmd1 Tmprss12 Zfp641 Olr1106 Faim2 Aqp5 Spats2 Prpf40b Prph Cers5 Ccnt1 Slc48a1 Tmem106c Tuba1b Dnajc22 Dhh Cacnb3 Rhebl1 Adcy6 Fkbp11 Mcrs1 Tmbim6 Dip2b Fmnl3 Gpd1 Nckap5l Kcnh3 Pfkm Bcdin3d Ccdc65 Asic1 Lima1 Rnd1 Rapgef3 C1ql4 Ddx23 Kansl2 Atf1 Kmt2d Smarcd1 NA Smagp NA NA NA NA NA NA NA Larp4 NA NA NA Prkag1 NA Olr1877 Olr1108 Fkbp11
Bone: periosteal estimation 11.2 66 22 200.0 0.99 0.0e+00 Mettl7a Asb8 Slc11a2 Csrnp2 Tuba1c Senp1 Letmd1 Tmprss12 Zfp641 Olr1106 Galnt6 Faim2 Aqp5 Spats2 Prpf40b Prph Cers5 Ccnt1 Slc48a1 Tmem106c Tuba1b Dnajc22 Dhh Cacnb3 Rhebl1 Adcy6 Fkbp11 Mcrs1 Tmbim6 Hdac7 Dip2b Fmnl3 Gpd1 Nckap5l Kcnh3 Pfkm Bcdin3d Ccdc65 Asic1 Lima1 Rnd1 Rapgef3 C1ql4 Ddx23 Kansl2 Atf1 Kmt2d Smarcd1 NA Smagp NA NA NA NA NA NA NA Larp4 NA NA NA Prkag1 NA Olr1877 Olr1108 Fkbp11
Bone: periosteal perimeter 10.2 60 0 0.0 1.00 0.0e+00 Mettl7a Asb8 Slc11a2 Csrnp2 Tuba1c Senp1 Letmd1 Tmprss12 Zfp641 Olr1106 Galnt6 Faim2 Spats2 Prpf40b Prph Cers5 Ccnt1 Slc48a1 Tmem106c Tuba1b Dnajc22 Dhh Cacnb3 Rhebl1 Adcy6 Fkbp11 Tmbim6 Hdac7 Dip2b Fmnl3 Gpd1 Nckap5l Kcnh3 Pfkm Bcdin3d Ccdc65 Asic1 Lima1 Rnd1 Rapgef3 Ddx23 Kansl2 Atf1 Kmt2d Smarcd1 NA Smagp NA NA NA NA Larp4 NA NA NA Prkag1 NA Olr1877 Olr1108 Fkbp11
Bone: post-yield work 82.8 1 1 9.1 0.00 1.0e+00 NA
Bone: tissue strength 81.0 1 1 9.1 0.00 1.0e+00 NA
Bone: trabecular number 29.5 2 1 9.1 0.00 1.0e+00 Ccdc65 NA
Bone: trabecular thickness 13.8 1 0 0.0 0.00 1.0e+00 NA
Bone: trabecular tissue density 43.1 1 1 9.1 0.00 1.0e+00 NA
Delta time in open arm before/after self-admin 40.2 1 1 9.1 0.00 1.0e+00 NA
Time in closed arm before self-admin 50.0 1 1 9.1 0.00 1.0e+00 NA
Time in closed arm after self-admin 40.2 1 1 9.1 0.00 1.0e+00 NA
Time in open arm after self-admin 31.3 1 1 9.1 0.00 1.0e+00 NA
Delta time to tail flick, test, before/after SA 20.0 1 0 0.0 0.00 1.0e+00 NA
Time >=10cm from walls, locomotor time 1 19.5 1 0 0.0 0.00 1.0e+00 NA
Time >=10cm from walls, locomotor time 2 27.2 1 1 9.1 0.00 1.0e+00 NA
Distance moved, locomotor task time 2 13.1 1 0 0.0 0.00 1.0e+00 NA
Weight adjusted by age 25.0 1 1 9.1 0.00 1.0e+00 NA
Run reversals in cocaine runway, males 39.3 1 1 9.1 0.00 1.0e+00 NA
Latency to leave start box in cocaine runway 18.8 1 0 0.0 0.00 1.0e+00 NA
Cd content in liver 140.5 1 1 9.1 0.00 1.0e+00 NA
Co content in liver 83.2 1 1 9.1 0.00 1.0e+00 NA
K content in liver 62.6 1 1 9.1 0.00 1.0e+00 NA
Mn content in liver 130.2 1 1 9.1 0.00 1.0e+00 NA
Rb content in liver 31.4 1 1 9.1 0.00 1.0e+00 NA
Se content in liver 47.0 1 1 9.1 0.00 1.0e+00 NA
Zn content in liver 46.0 1 1 9.1 0.00 1.0e+00 NA

chisq ratio: Average Chi2 statistic for the selected genes in the secondary trait, divided by the average statistic for all genes in the secondary trait. # genes+: Shared significant genes at Bonferroni correction. # genes++: Shared significant genes at transcriptome-wide significance. % genes++: Number of [++] genes as a percentage of primary trait’s total joint genes. corr: Correlation of effect sizes across the [+] genes.

Associations by panel

tissue modality # hits % hits/tests avg chisq
Adipose alternative polyA 6 0.283 1.5
Adipose alternative TSS 3 0.186 1.5
Adipose gene expression 25 0.301 1.6
Adipose isoform ratio 7 0.248 1.5
Adipose intron excision ratio 3 0.103 1.4
Adipose mRNA stability 9 0.261 1.5
BLA alternative polyA 8 0.667 1.6
BLA alternative TSS 3 0.356 1.7
BLA gene expression 22 0.363 1.7
BLA isoform ratio 13 0.739 1.7
BLA intron excision ratio 9 0.301 1.5
BLA mRNA stability 8 0.395 1.6
Brain alternative polyA 8 0.399 1.4
Brain alternative TSS 0 0.000 1.8
Brain gene expression 29 0.320 1.6
Brain isoform ratio 7 0.221 1.6
Brain intron excision ratio 13 0.241 1.5
Brain mRNA stability 13 0.298 1.6
Eye alternative polyA 4 2.235 2.4
Eye alternative TSS 2 0.833 2.2
Eye gene expression 5 0.444 1.6
Eye isoform ratio 3 0.847 1.8
Eye intron excision ratio 4 0.653 1.8
Eye mRNA stability 3 1.288 1.9
IL alternative polyA 5 0.821 1.6
IL alternative TSS 0 0.000 1.7
IL gene expression 13 0.357 1.7
IL isoform ratio 3 0.380 1.6
IL intron excision ratio 1 0.104 1.7
IL mRNA stability 3 0.270 1.5
LHb alternative polyA 6 1.043 1.6
LHb alternative TSS 0 0.000 1.7
LHb gene expression 12 0.374 1.7
LHb isoform ratio 3 0.398 1.6
LHb intron excision ratio 1 0.097 1.5
LHb mRNA stability 3 0.290 1.5
Liver alternative polyA 2 0.133 1.4
Liver alternative TSS 3 0.197 1.7
Liver gene expression 19 0.264 1.6
Liver isoform ratio 6 0.251 1.6
Liver intron excision ratio 3 0.069 1.5
Liver mRNA stability 6 0.244 1.5
NAcc alternative polyA 7 0.534 1.5
NAcc alternative TSS 0 0.000 1.7
NAcc gene expression 15 0.238 1.6
NAcc isoform ratio 7 0.372 1.6
NAcc intron excision ratio 6 0.196 1.6
NAcc mRNA stability 10 0.442 1.6
OFC alternative polyA 8 1.370 1.6
OFC alternative TSS 0 0.000 1.4
OFC gene expression 11 0.297 1.6
OFC isoform ratio 4 0.490 1.7
OFC intron excision ratio 2 0.199 1.6
OFC mRNA stability 7 0.648 1.6
PL alternative polyA 4 0.281 1.6
PL alternative TSS 3 0.255 1.8
PL gene expression 21 0.284 1.6
PL isoform ratio 9 0.407 1.8
PL intron excision ratio 11 0.307 1.5
PL mRNA stability 8 0.274 1.6

avg chisq: Average Chi2 (squared Z-score) across all models in this panel for this trait.