Hub : Genes

Pag1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	NAcc	gene expression	Pag1	0.17	0.09	5.0e-16	0.11	0.11	0.1	0.11	1.2e-12	9.7e-13	1.9e-11	1.9e-12
2	BLA	gene expression	Pag1	0.12	0.07	1.1e-04	0.04	0.04	0.03	0.04	2.8e-03	3.7e-03	7.8e-03	3.9e-03
3	LHb	gene expression	Pag1	0.26	0.14	3.5e-03	0.03	0.01	0	0.01	6.8e-02	1.9e-01	2.4e-01	1.5e-01
4	Liver	mRNA stability	Pag1	0.03	0.03	7.0e-04	0.01	0.01	0.01	0.01	2.3e-02	1.1e-02	3.0e-02	1.8e-02
5	pVTA	gene expression	Pag1	0.22	0.12	8.0e-07	0.14	0.17	0.14	0	1.7e-06	1.0e-07	9.1e-07	1.8e-01
6	RMTg	gene expression	Pag1	0.22	0.15	1.1e-03	0.06	0.09	0.07	0.08	8.3e-03	2.5e-03	5.4e-03	4.3e-03
7	Brain	gene expression	Pag1	0.08	0.05	3.2e-05	0.03	0.02	0.01	0.02	1.0e-03	8.6e-03	3.0e-02	2.5e-03
8	Brain	mRNA stability	Pag1	0.06	0.04	2.4e-03	0.02	0.02	0.02	0.02	2.8e-03	7.2e-03	3.2e-03	2.6e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8
Bone: apparent density	1.5	2.6	3.9	1.3	-1.5	-1.5	1.8	1.8	2.0	-2.0	0.0
Area under the delay curve	1.1	1.2	1.7	-1.0	1.0	1.1	-1.3	-1.2	-1.3	1.2	0.0
BMI with tail	1.4	4.6	10.5	-3.2	2.7	2.8	-2.2	-1.4	-1.4	1.7	0.0
BMI without tail	3.9	8.1	15.0	-3.9	3.5	3.5	-3.0	-2.2	-2.3	2.4	0.0
Body weight	0.3	1.3	4.6	-2.2	1.6	1.6	-1.0	-0.3	-0.3	0.3	0.0
Weight adjusted by age	0.2	0.2	0.6	-0.4	0.5	0.5	-0.5	-0.8	-0.5	0.4	0.0
Bone surface	3.1	5.5	9.4	1.4	-1.9	-2.0	2.7	2.9	3.1	-3.0	0.0
Bone volume	2.8	4.7	8.3	1.3	-1.7	-1.8	2.5	2.6	2.9	-2.9	0.0
Breakpoint value in progressive ratio session	1.4	1.6	2.3	-1.3	1.4	1.5	-1.3	-1.5	-1.2	1.1	0.0
Number of licking bursts	0.5	0.6	1.2	0.5	-0.7	-0.7	0.8	1.1	0.9	-0.9	0.0
Context. condit. distance diff. score	0.0	0.0	0.0	0.0	-0.0	-0.2	-0.1	0.1	-0.2	0.2	0.0
Locomotion velocity, session 1	2.1	2.3	3.5	-1.5	1.7	1.6	-1.6	-1.9	-1.6	1.3	0.0
Locomotion distance, session 1	0.6	0.7	1.5	-1.2	1.2	1.1	-0.8	-0.9	-0.5	0.2	0.0
Locomotion velocity, session 2	1.8	2.1	3.0	-1.7	1.7	1.7	-1.6	-1.5	-1.4	1.1	0.0
Locomotion distance, session 2	0.8	1.1	2.3	-1.5	1.5	1.5	-0.9	-1.1	-0.5	0.2	0.0
Locomotion velocity, session 3	0.0	0.0	0.1	0.1	0.0	-0.0	-0.1	-0.0	-0.3	0.0	0.0
Locomotion distance, session 3	0.3	0.3	0.8	0.3	-0.4	-0.3	0.7	0.8	0.8	-0.9	0.0
Stereotopy head waving bouts, day 3	0.1	0.1	0.2	-0.3	0.4	0.2	-0.0	-0.3	0.1	-0.5	0.0
Stereotopy head waving duration, day 3	0.3	0.4	0.7	-0.7	0.8	0.7	-0.7	-0.7	-0.7	0.4	0.0
Locomotion velocity, session 7	5.6	6.1	11.2	1.8	-2.1	-2.2	2.9	2.6	3.2	-3.4	0.0
Locomotion distance, session 7	4.3	5.4	7.1	2.2	-2.4	-2.5	2.7	2.4	2.6	-2.6	0.0
Stereotopy head waving bouts, day 7	0.3	0.4	1.0	-1.0	0.9	0.8	-0.6	-0.3	-0.3	0.4	0.0
Stereotopy head waving duration, day 7	1.0	1.2	1.6	-1.3	1.2	1.2	-1.2	-1.0	-1.1	1.2	0.0
Locomotion velocity, session 8	3.2	3.8	4.9	-2.1	2.2	2.2	-2.2	-2.1	-2.0	1.8	0.0
Locomotion distance, session 8	0.6	0.9	1.6	-1.3	1.3	1.1	-0.9	-0.9	-0.7	0.5	0.0
Degree of sensitization distance	0.3	0.3	0.5	0.7	-0.6	-0.7	0.6	0.3	0.5	-0.7	0.0
Degree of sensitization stereotypy	1.5	1.6	2.3	-1.5	1.5	1.5	-1.4	-1.1	-1.2	1.3	0.0
Conditioned locomotion	0.2	0.2	0.4	-0.4	0.5	0.5	-0.4	-0.6	-0.4	0.3	0.0
Cocaine response after cond. corrected	0.7	0.7	1.5	1.2	-1.0	-1.1	0.9	0.6	0.7	-0.6	0.0
Cocaine response after cond. not corrected	1.2	1.3	2.5	1.6	-1.4	-1.4	1.2	0.8	0.9	-1.0	0.0
Cocaine response before conditioning	0.2	0.2	0.6	0.4	-0.4	-0.3	0.5	0.4	0.5	-0.7	0.0
Saline control response	1.5	1.9	3.6	0.7	-1.0	-1.1	1.6	1.8	1.9	-1.9	0.0
Bone: connectivity density	1.9	3.0	4.1	1.5	-1.8	-1.8	1.9	1.9	2.0	-1.9	0.0
Bone: cortical apparent density	0.7	0.9	1.3	-0.9	0.9	1.0	-1.1	-1.1	-1.1	1.0	0.0
Bone: cortical area	0.2	0.3	0.9	-0.4	0.2	0.1	0.4	0.9	0.8	-0.9	0.0
Bone: cortical porosity	0.0	0.0	0.1	-0.2	0.2	0.1	0.1	0.0	0.1	-0.3	0.0
Bone: cortical porosity	0.1	0.1	0.1	-0.3	0.4	0.3	-0.1	-0.2	-0.0	-0.2	0.0
Bone: cortical thickness	0.2	0.3	0.8	-0.9	0.8	0.7	-0.3	0.0	0.0	-0.4	0.0
Bone: cortical thickness	3.1	3.6	5.3	-2.2	2.3	2.2	-2.1	-1.8	-1.9	1.6	0.0
Bone: cortical tissue density	0.8	1.0	1.4	-0.9	0.9	1.0	-1.2	-1.2	-1.2	1.1	0.0
Condit. Reinf. active minus inactive responses	3.1	3.5	7.8	-2.8	2.5	2.5	-1.8	-1.8	-1.0	0.6	0.0
Condit. Reinf. active-inactive response ratio	4.3	4.6	9.8	-3.1	2.8	2.9	-2.1	-2.1	-1.3	0.8	0.0
Condit. Reinf. active responses	2.2	2.7	6.8	-2.6	2.3	2.3	-1.4	-1.4	-0.6	0.3	0.0
Condit. Reinf. inactive responses	0.0	0.0	0.1	-0.4	0.3	0.2	-0.0	0.2	0.2	-0.2	0.0
Incentive salience index mean	3.1	3.8	8.4	-2.9	2.6	2.6	-1.8	-1.8	-1.0	0.6	0.0
Condit. Reinf. lever presses	1.3	1.7	4.0	-2.0	1.8	1.7	-1.3	-1.2	-0.7	0.6	0.0
Condit. Reinf. active minus inactive responses	2.8	3.5	6.6	1.0	-1.5	-1.4	2.2	2.2	2.5	-2.6	0.0
Condit. Reinf. active-inactive response ratio	1.7	1.8	3.7	0.4	-0.9	-0.8	1.5	1.8	1.9	-1.9	0.0
Condit. Reinf. active responses	3.5	4.9	8.8	1.4	-1.8	-1.8	2.6	2.5	2.9	-3.0	0.0
Condit. Reinf. inactive responses	0.3	0.4	0.6	0.5	-0.5	-0.6	0.7	0.4	0.8	-0.8	0.0
Condit. Reinf. lever presses	1.3	1.8	3.6	0.8	-1.1	-1.1	1.6	1.5	1.8	-1.9	0.0
Condit. Reinf. lever reinforcers received	3.7	5.1	8.9	1.5	-1.9	-1.9	2.7	2.6	3.0	-3.0	0.0
Conditioned reinforcement - actives	4.1	4.1	5.4	1.9	-2.2	-2.1	2.3	2.2	2.3	-2.1	0.0
Conditioned reinforcement - inactives	0.1	0.1	0.2	0.4	-0.4	-0.2	0.3	-0.2	0.1	-0.3	0.0
Conditioned locomotion	3.0	3.6	6.4	1.4	-1.9	-1.8	2.1	2.5	2.3	-2.0	0.0
Patch foraging indifference point 0 sec	0.4	0.7	1.7	1.3	-1.0	-1.3	0.8	0.5	0.4	-0.0	0.0
Patch foraging indifference point AUC	0.9	1.1	2.6	-0.5	1.0	0.9	-1.1	-1.6	-1.3	0.9	0.0
Delay disc. indifference point, 0s delay	0.0	0.0	0.1	0.2	-0.3	-0.3	0.2	0.3	0.1	-0.1	0.0
Delay disc. indifference point, 16s delay	1.3	1.3	1.9	-1.0	1.1	1.2	-1.3	-1.3	-1.4	1.3	0.0
Delay disc. indifference point, 2s delay	0.3	0.3	1.0	-1.0	0.8	0.7	-0.3	-0.1	0.2	-0.0	0.0
Delay disc. indifference point, 24s delay	0.2	0.2	0.4	-0.2	0.2	0.4	-0.5	-0.5	-0.6	0.6	0.0
Delay disc. indifference point, 4s delay	1.8	1.9	2.7	-1.5	1.5	1.4	-1.6	-1.3	-1.6	1.5	0.0
Delay disc. indifference point, 8s delay	0.3	0.3	0.9	-0.0	0.2	0.2	-0.7	-0.7	-0.9	0.7	0.0
Indifference point function ln k	0.0	0.0	0.2	-0.1	-0.0	-0.1	-0.1	0.4	-0.1	0.1	0.0
Indifference point function log k	0.0	0.0	0.2	-0.1	-0.0	-0.1	-0.1	0.4	-0.1	0.1	0.0
Patch foraging total patch changes 0 sec	0.2	0.3	1.0	1.0	-0.7	-0.9	0.3	0.0	-0.2	0.5	0.0
Patch foraging total patch changes 12 sec	0.2	0.2	0.9	0.9	-0.5	-0.7	0.1	-0.4	-0.3	0.3	0.0
Patch foraging total patch changes 18 sec	1.0	1.3	2.5	-0.7	1.3	0.9	-1.3	-1.6	-1.5	1.1	0.0
Patch foraging total patch changes 24 sec	0.1	0.1	0.2	0.5	-0.1	-0.4	-0.1	-0.3	-0.4	0.3	0.0
Patch foraging total patch changes 6 sec	0.3	0.4	1.0	0.1	0.3	0.2	-0.6	-1.0	-1.0	0.7	0.0
Patch foraging time to switch 0 sec	0.7	1.0	3.2	-1.8	1.4	1.4	-0.8	-0.6	-0.2	-0.1	0.0
Patch foraging water rate 0 sec	0.1	0.2	0.8	0.5	-0.3	-0.3	-0.2	-0.3	-0.6	0.9	0.0
Patch foraging water rate 12 sec	1.0	1.5	2.3	1.4	-1.4	-1.5	1.3	1.4	1.1	-1.1	0.0
Patch foraging water rate 18 sec	0.6	0.8	1.3	0.8	-1.0	-0.8	0.9	1.1	1.0	-0.9	0.0
Patch foraging water rate 24 sec	0.1	0.1	0.3	0.3	-0.3	-0.2	-0.2	-0.1	-0.4	0.5	0.0
Patch foraging water rate 6 sec	1.7	2.5	4.0	1.7	-1.8	-1.8	1.7	2.0	1.5	-1.2	0.0
Seeking ratio, delayed vs. immediate footshock	7.2	8.3	11.2	3.3	-3.3	-3.3	3.1	3.1	2.7	-2.7	0.0
Distance traveled before self-admin	0.3	0.3	1.3	0.2	-0.4	-0.5	0.4	1.1	0.5	-0.3	0.0
Distance traveled after self-admin	0.1	0.1	0.2	0.2	-0.2	-0.3	-0.1	0.3	-0.2	0.5	0.0
Extensor digitorum longus weight	7.3	28.8	46.6	-6.8	6.4	6.5	-5.9	-4.9	-4.8	4.3	0.0
Bone: elastic displacement	0.2	0.2	1.1	-0.3	0.2	0.3	0.3	0.1	0.5	-1.1	0.0
Bone: elastic work	0.3	0.3	1.5	-0.2	0.0	0.2	0.5	0.5	0.7	-1.2	0.0
Bone: endosteal estimation	1.2	2.6	5.8	0.2	-0.9	-0.9	1.7	2.4	2.4	-2.2	0.0
Bone: endosteal perimeter	0.7	1.5	2.6	0.7	-1.1	-1.1	1.4	1.6	1.6	-1.5	0.0
Epididymis fat weight	0.0	0.1	0.3	0.3	-0.1	-0.3	-0.3	-0.4	-0.6	0.2	0.0
Delta time in closed arm before/after self-admin	0.2	0.2	0.7	0.3	-0.5	-0.5	0.3	0.9	0.2	-0.1	0.0
Delta time in open arm before/after self-admin	0.0	0.0	0.0	0.1	0.1	-0.0	-0.1	-0.2	-0.1	0.1	0.0
Diff in mean of infusions in LGA sessions	1.3	1.5	3.1	-1.8	1.6	1.7	-1.2	-1.0	-0.7	0.5	0.0
Delay discount exponential model param	0.8	0.9	1.3	0.9	-0.9	-1.0	1.1	1.1	1.1	-1.0	0.0
Extinction: sum of active levers before priming	1.1	1.1	1.8	-1.0	1.1	1.1	-1.2	-1.3	-1.1	1.0	0.0
Active lever presses in extinction session 6	0.3	0.3	0.4	0.5	-0.6	-0.5	0.6	0.6	0.5	-0.4	0.0
Bone: final force	0.2	0.2	0.5	-0.7	0.3	0.3	0.2	0.7	0.7	-0.6	0.0
Bone: final moment	0.3	0.5	1.5	-0.3	-0.1	-0.2	0.6	1.2	1.1	-1.0	0.0
Food consumed during 24 hour testing period	1.4	1.7	2.6	-1.6	1.6	1.6	-1.4	-1.3	-1.3	0.8	0.0
Glucose	1.2	1.8	2.8	-1.6	1.7	1.6	-1.5	-1.3	-1.4	1.1	0.0
Heart weight	1.4	1.9	3.1	1.7	-1.8	-1.7	1.4	1.5	1.1	-1.1	0.0
Delay discount hyperbolic model param	1.1	1.2	1.6	1.1	-1.1	-1.1	1.3	1.2	1.3	-1.1	0.0
Intermittent access intake day 1-15 change	3.6	3.5	6.0	2.4	-2.5	-2.4	1.9	1.8	1.4	-1.3	0.0
Intermittent access intake escalation	2.8	2.8	4.7	2.1	-2.2	-2.1	1.7	1.6	1.3	-1.1	0.0
Intermittent access intake escalation 2	4.1	4.1	6.2	2.5	-2.5	-2.5	2.2	1.9	1.8	-1.6	0.0
Intermitt. access day 1 inactive lever presses	1.3	1.4	3.0	-0.6	0.9	0.9	-1.4	-1.6	-1.7	1.4	0.0
Intermitt. access day 15 inactive lever presses	0.9	1.0	3.3	0.5	0.1	0.3	-1.0	-1.8	-1.7	1.0	0.0
Intermitt. access escalation Index	0.1	0.1	0.1	-0.1	0.2	0.0	-0.3	-0.2	-0.4	0.3	0.0
Intermittent access day 1 total infusions	1.1	1.3	2.0	1.3	-1.2	-1.2	1.3	0.8	1.2	-1.4	0.0
Intermittent access day 15 total infusions	5.6	6.2	8.6	2.8	-2.9	-2.9	2.7	2.4	2.4	-2.4	0.0
Intermittent access terminal intake (last 3 days)	4.3	4.7	7.3	2.7	-2.6	-2.6	2.4	1.8	2.0	-2.1	0.0
Intermittent access total infusions	2.9	3.2	4.8	2.2	-2.1	-2.0	1.9	1.5	1.7	-1.8	0.0
Intermittent access day 1 locomotion	0.1	0.1	0.3	0.5	-0.4	-0.3	0.4	0.2	0.4	-0.5	0.0
Intermittent access day 15 total locomotion	0.5	0.5	0.8	0.7	-0.8	-0.7	0.9	0.7	0.9	-0.8	0.0
Intermittent access total locomotion	0.4	0.4	0.8	0.9	-0.8	-0.7	0.7	0.3	0.5	-0.7	0.0
Intermittent access standard deviation	3.0	3.1	6.3	2.5	-2.4	-2.4	1.7	1.5	1.0	-1.1	0.0
Left kidney weight	0.6	1.7	3.1	1.7	-1.8	-1.7	1.2	1.3	0.8	-1.0	0.0
Right kidney weight	0.2	0.6	1.8	1.4	-1.0	-1.2	0.5	0.4	-0.1	-0.1	0.0
Cocaine induced anxiety	0.4	0.5	1.1	-0.3	0.5	0.5	-0.8	-1.0	-1.1	0.9	0.0
Post-drug Anxiety	1.5	1.7	2.2	-1.3	1.5	1.4	-1.5	-1.4	-1.4	1.3	0.0
Baseline Anxiety	0.1	0.1	0.3	-0.3	0.1	0.0	0.2	0.4	0.5	-0.4	0.0
Tail length	0.3	0.8	1.6	-1.2	1.1	1.0	-1.0	-0.8	-0.8	0.7	0.0
Length with tail	0.1	0.2	0.8	0.2	-0.3	-0.4	0.5	0.5	0.6	-0.9	0.0
Length without tail	1.1	2.4	3.7	1.5	-1.6	-1.6	1.8	1.5	1.7	-1.9	0.0
Times rat made contact with spout	0.0	0.0	0.1	0.1	-0.2	-0.2	0.1	0.4	0.2	-0.2	0.0
Lifetime Intake	2.5	2.9	5.0	2.2	-2.1	-2.0	1.8	1.3	1.4	-1.6	0.0
Liver weight, left	1.4	2.3	3.8	-1.9	1.8	1.9	-1.6	-1.4	-1.2	1.3	0.0
Liver weight, right	0.6	1.1	2.8	-0.4	0.7	0.8	-1.0	-1.3	-1.3	1.7	0.0
Locomotor activity	0.0	0.0	0.3	-0.1	0.0	-0.0	0.0	0.6	0.1	0.1	0.0
Locomotor testing distance	0.0	0.0	0.2	-0.1	0.0	-0.1	0.1	0.4	0.2	0.1	0.0
Locomotor testing rearing	0.5	0.8	1.4	1.2	-1.1	-1.1	1.0	0.9	0.7	-0.3	0.0
Locomotion in novel chamber	0.7	0.9	1.6	-1.2	1.2	1.2	-1.0	-0.7	-0.7	1.0	0.0
Locomotion in novel chamber post-restriction	0.0	0.0	0.1	0.1	-0.1	-0.1	-0.2	-0.2	-0.3	0.2	0.0
Fecal boli incidents, locomotor time 1	0.2	0.2	0.6	-0.4	0.6	0.3	-0.5	-0.8	-0.4	0.3	0.0
Change in fecal boli incidents, locomotor task	2.4	2.2	3.4	1.5	-1.6	-1.6	1.6	1.8	1.5	-1.4	0.0
Time >=10cm from walls, locomotor time 1	1.5	1.5	2.6	0.8	-1.2	-1.2	1.4	1.6	1.6	-1.3	0.0
Bouts of movement, locomotor time 1	0.4	0.4	1.3	0.7	-0.3	-0.3	-0.5	-0.6	-1.2	0.9	0.0
Total resting periods, locomotor time 1	0.3	0.3	0.7	0.7	-0.4	-0.3	-0.3	-0.5	-0.8	0.7	0.0
Rest time, locomotor task time 1	0.2	0.2	0.6	0.8	-0.6	-0.6	0.1	0.1	-0.3	0.2	0.0
Distance moved, locomotor task time 1	0.0	0.0	0.1	-0.1	-0.1	0.0	0.1	0.4	0.3	-0.1	0.0
Vertical activity count, locomotor time 1	0.4	0.4	1.1	-0.5	-0.1	0.0	0.5	1.0	1.0	-0.7	0.0
Time >=10cm from walls, locomotor time 2	0.8	0.9	2.2	0.2	-0.7	-0.6	1.1	1.4	1.5	-1.0	0.0
Bouts of movement, locomotor time 2	0.9	0.9	2.7	-0.1	0.3	0.5	-1.2	-1.1	-1.7	1.3	0.0
Total resting periods, locomotor time 2	0.9	1.0	3.0	-0.1	0.3	0.5	-1.2	-1.2	-1.7	1.4	0.0
Rest time, locomotor task time 2	0.4	0.4	1.0	-0.3	0.5	0.4	-0.8	-0.7	-1.0	0.8	0.0
Distance moved, locomotor task time 2	0.0	0.0	0.0	0.1	-0.2	-0.1	0.1	0.1	0.0	0.0	0.0
Vertical activity count, locomotor time 2	0.5	0.5	1.6	-1.3	0.9	1.0	-0.6	-0.1	-0.1	0.5	0.0
Light reinforcement 1	1.5	2.7	4.9	-1.1	1.6	1.5	-1.9	-2.2	-2.1	1.7	0.0
Light reinforcement 2	2.9	3.9	4.9	-2.1	2.1	2.2	-2.2	-2.1	-2.1	2.1	0.0
Bone: marrow area	1.1	2.3	5.3	0.0	-0.8	-0.8	1.6	2.3	2.3	-2.1	0.0
Bone: maximum diameter	0.2	0.4	1.3	0.1	-0.4	-0.5	0.6	1.2	0.8	-0.6	0.0
Bone: maximum force	0.2	0.3	0.8	-0.5	0.2	0.2	0.4	0.9	0.8	-0.9	0.0
Bone: maximum moment	0.5	0.8	2.0	-0.1	-0.3	-0.3	0.9	1.4	1.3	-1.4	0.0
Mean time between licks in bursts	0.4	0.6	1.1	-1.0	1.1	1.1	-0.6	-1.0	-0.3	-0.3	0.0
Mean num. licks in bursts	0.3	0.3	0.6	-0.4	0.5	0.5	-0.7	-0.7	-0.7	0.7	0.0
Cd content in liver	1.8	1.9	4.1	-0.7	0.9	1.0	-1.6	-1.7	-1.9	2.0	0.0
Co content in liver	0.4	0.4	1.2	-0.1	0.3	0.3	-0.7	-0.7	-1.1	1.1	0.0
Cu content in liver	2.6	3.1	5.2	2.3	-2.2	-2.2	1.9	1.7	1.5	-1.2	0.0
Fe content in liver	1.0	1.2	3.5	0.1	-0.4	-0.5	1.1	1.2	1.6	-1.9	0.0
K content in liver	0.5	0.5	1.2	1.0	-1.0	-1.1	0.7	0.4	0.5	-0.4	0.0
Mg content in liver	0.5	0.5	0.9	0.8	-0.8	-0.9	0.8	0.6	0.8	-0.8	0.0
Mn content in liver	0.1	0.1	0.2	-0.3	0.3	0.1	-0.3	-0.5	-0.2	-0.1	0.0
Na content in liver	0.6	0.6	1.2	0.9	-1.0	-0.9	0.8	1.1	0.7	-0.4	0.0
Rb content in liver	0.1	0.1	0.2	0.0	0.2	-0.1	-0.3	-0.5	-0.5	0.5	0.0
Se content in liver	0.1	0.1	0.4	0.5	-0.4	-0.6	0.3	0.2	0.2	0.1	0.0
Sr content in liver	0.1	0.1	0.2	-0.5	0.3	0.3	-0.2	-0.1	-0.0	-0.5	0.0
Zn content in liver	1.0	1.1	2.2	1.5	-1.4	-1.3	1.1	0.8	0.7	-0.6	0.0
Bone: minimum diameter	0.6	1.2	3.0	-1.3	0.8	0.6	0.5	1.0	1.5	-1.7	0.0
Time in familiar zone, hab. session 1	0.4	0.3	0.8	0.9	-0.8	-0.8	0.4	0.7	0.1	-0.0	0.0
Time in novel zone, hab. session 1	0.1	0.1	0.4	-0.2	0.4	0.3	-0.2	-0.7	-0.3	0.2	0.0
Total zone transitions, hab. session 1	0.6	0.8	1.4	-1.2	1.1	1.2	-0.9	-1.0	-0.7	0.3	0.0
Total locomotion distance, hab. session 1	0.1	0.2	0.6	-0.7	0.6	0.6	-0.1	-0.3	0.2	-0.4	0.0
Locomotion velocity, hab. session 1	0.3	0.5	1.3	-1.2	1.0	1.0	-0.5	-0.6	-0.0	-0.2	0.0
Time in familiar zone, hab. session 2	1.0	1.0	3.0	1.7	-1.4	-1.4	0.7	0.7	0.1	0.0	0.0
Time in novel zone, hab. session 2	0.3	0.3	1.2	-1.1	0.8	0.8	-0.3	-0.1	0.2	-0.2	0.0
Total zone transitions, hab. session 2	0.3	0.4	0.8	-0.4	0.6	0.5	-0.7	-0.9	-0.9	0.7	0.0
Total locomotion distance, hab. session 2	0.1	0.1	0.3	-0.5	0.5	0.4	-0.3	-0.3	-0.2	0.0	0.0
Locomotion velocity, hab. session 2	0.1	0.1	0.2	-0.4	0.4	0.3	-0.2	-0.3	-0.1	-0.0	0.0
Novel to familiar place preference ratio	0.1	0.1	0.1	-0.4	0.2	0.2	0.1	0.4	0.3	-0.2	0.0
Novelty place preference	0.0	0.0	0.2	-0.2	0.0	0.0	0.2	0.4	0.3	-0.2	0.0
Time in novel zone, NPP test	0.0	0.0	0.1	-0.2	0.1	0.1	-0.0	0.3	0.1	0.0	0.0
Total zone transitions, NPP test	0.6	0.8	1.4	-0.9	1.0	0.9	-1.0	-1.2	-1.0	0.8	0.0
Total locomotion distance, NPP test	0.2	0.3	0.6	-0.8	0.8	0.7	-0.4	-0.5	-0.2	0.1	0.0
Locomotion velocity, NPP test	0.1	0.1	0.3	-0.5	0.5	0.3	-0.1	-0.2	0.2	-0.2	0.0
Intraocular pressure	1.3	1.9	3.8	-1.9	1.8	1.7	-1.4	-1.1	-1.0	1.0	0.0
Delta distance traveled before/after self-admin	0.3	0.3	0.5	0.6	-0.7	-0.6	0.6	0.6	0.6	-0.4	0.0
Delta ambulatory time before/after self-admin	0.6	0.7	1.2	1.1	-1.0	-1.0	0.9	0.7	0.7	-0.5	0.0
Parametrial fat weight	0.2	0.3	0.7	-0.5	0.4	0.4	-0.7	-0.6	-0.7	0.8	0.0
Pavlov. Cond. lever latency	0.3	0.4	1.0	1.0	-0.9	-0.8	0.6	0.5	0.2	-0.2	0.0
Pavlov. Cond. magazine entry latency	0.2	0.2	0.7	-0.8	0.7	0.6	-0.4	-0.1	-0.0	0.2	0.0
Pavlov. Cond. change in total contacts	1.6	1.7	3.7	-1.9	1.8	1.7	-1.3	-1.0	-0.8	0.8	0.0
Pavlov. Cond. index score	0.6	0.7	1.4	-1.2	1.1	1.0	-0.9	-0.7	-0.6	0.7	0.0
Pavlov. Cond. latency score	0.5	0.7	1.2	-1.1	1.1	1.0	-0.9	-0.8	-0.6	0.8	0.0
Pavlov. Cond. lever contacts	0.3	0.4	1.2	-1.1	1.0	0.7	-0.4	-0.3	0.1	-0.1	0.0
Pavlov. Cond. magazine entry number	0.6	0.8	1.4	1.2	-1.1	-1.0	0.9	0.6	0.7	-0.9	0.0
Pavlov. Cond. intertrial magazine entries	0.6	0.7	1.3	0.9	-0.9	-0.9	1.0	0.5	0.9	-1.1	0.0
Pavlov. Cond. lever-magazine prob. diff.	0.5	0.7	1.3	-1.1	1.1	1.0	-0.8	-0.6	-0.5	0.7	0.0
Pavlov. Cond. response bias	0.4	0.4	1.5	-1.2	1.0	0.9	-0.5	-0.2	-0.1	0.2	0.0
Pavlov. Cond. lever latency	1.1	1.4	1.8	-1.2	1.3	1.4	-1.3	-1.2	-1.3	1.2	0.0
Pavlov. Cond. magazine entry latency	0.0	0.0	0.0	-0.1	0.1	0.1	-0.0	0.0	0.1	-0.1	0.0
Pavlov. Cond. change in total contacts	0.5	0.7	2.3	-0.1	-0.2	-0.3	0.9	0.9	1.3	-1.5	0.0
Pavlov. Cond. index score	0.4	0.5	1.3	0.1	-0.4	-0.4	0.8	0.8	1.0	-1.1	0.0
Pavlov. Cond. latency score	0.4	0.5	1.2	0.3	-0.5	-0.5	0.8	0.9	1.0	-1.1	0.0
Pavlov. Cond. lever contacts	0.8	1.1	1.4	0.9	-1.0	-1.1	1.2	1.0	1.2	-1.2	0.0
Pavlov. Cond. magazine entry number	0.0	0.0	0.1	0.4	-0.1	-0.1	-0.1	-0.2	-0.3	0.3	0.0
Pavlov. Cond. intertrial magazine entries	0.1	0.1	0.3	-0.5	0.4	0.4	-0.2	-0.1	0.0	-0.2	0.0
Pavlov. Cond. lever-magazine prob. diff.	0.4	0.5	1.3	0.3	-0.5	-0.5	0.8	0.8	1.0	-1.1	0.0
Pavlov. Cond. response bias	0.6	0.8	1.7	0.4	-0.6	-0.7	1.0	1.0	1.2	-1.3	0.0
Time in closed arm before self-admin	0.3	0.3	0.8	0.9	-0.8	-0.8	0.5	0.1	0.3	-0.4	0.0
Time in closed arm after self-admin	0.3	0.3	0.7	0.7	-0.8	-0.7	0.4	0.7	0.2	0.0	0.0
Time in open arm before self-admin	0.3	0.3	0.8	-0.4	0.1	0.1	0.5	0.8	0.8	-0.9	0.0
Time in open arm after self-admin	0.9	1.0	1.9	-1.3	1.4	1.2	-1.0	-1.0	-0.8	0.7	0.0
Bone: periosteal estimation	0.8	1.7	4.1	-0.5	-0.2	-0.3	1.2	2.0	2.0	-2.0	0.0
Bone: periosteal perimeter	0.6	1.0	2.4	0.3	-0.6	-0.7	1.0	1.5	1.4	-1.3	0.0
Bone: post-yield work	2.6	3.5	5.1	2.0	-2.1	-2.2	2.0	2.2	1.8	-1.6	0.0
Progressive ratio test 1 active lever presses	1.1	1.1	3.4	1.8	-1.5	-1.5	0.8	0.4	0.2	-0.6	0.0
Progressive ratio test 1 breakpoint	1.0	1.0	3.0	1.7	-1.4	-1.4	0.8	0.3	0.2	-0.6	0.0
Progressive ratio test 1 inactive lever presses	0.1	0.1	0.3	0.3	-0.2	-0.1	-0.3	-0.5	-0.6	0.2	0.0
Progressive ratio test 2 active lever presses	2.4	2.5	3.5	1.8	-1.9	-1.8	1.8	1.5	1.6	-1.6	0.0
Progressive ratio test 2 breakpoint	2.3	2.6	3.4	1.7	-1.8	-1.8	1.8	1.6	1.7	-1.7	0.0
Progressive ratio test 2 inactive lever presses	1.2	1.3	2.1	1.4	-1.4	-1.3	1.3	1.1	1.1	-1.1	0.0
Incentive Sensitization - Responses	2.1	2.1	3.6	1.1	-1.3	-1.3	1.7	1.6	1.9	-1.8	0.0
Incentive Sensitization - Breakpoint	2.1	2.2	3.5	1.2	-1.4	-1.4	1.7	1.6	1.9	-1.8	0.0
Sum of active levers in priming session hrs 5-6	0.2	0.2	0.4	0.3	-0.4	-0.2	0.5	0.4	0.6	-0.7	0.0
Progressive ratio	0.3	0.4	1.0	1.0	-1.0	-0.8	0.3	0.6	-0.1	-0.0	0.0
Food seeking constrained by brief footshock	1.7	2.1	4.9	-2.2	2.0	2.0	-1.3	-1.0	-0.7	1.0	0.0
Seeking ratio, punishment vs. effort	1.6	1.9	4.4	-2.1	2.0	1.9	-1.1	-1.3	-0.5	0.7	0.0
Retroperitoneal fat weight	0.0	0.1	0.2	0.4	-0.5	-0.5	0.3	0.2	0.2	-0.0	0.0
Reaction time number correct	0.6	0.9	2.3	0.3	-0.5	-0.6	1.1	1.2	1.4	-1.5	0.0
Reaction time mean minus median	4.1	5.4	9.9	-1.5	1.9	2.1	-2.6	-3.1	-3.0	2.8	0.0
Reaction time mean minus median AUC	4.5	5.9	9.9	-1.9	2.2	2.4	-2.7	-3.1	-2.9	2.7	0.0
Reaction time num false alarms	1.4	1.8	4.1	0.7	-1.1	-1.0	1.6	1.7	2.0	-1.5	0.0
Reaction time num false alarms AUC	1.2	1.7	3.6	0.8	-1.1	-1.1	1.6	1.6	1.9	-1.3	0.0
Reaction time trials correct on left	0.6	0.9	2.3	0.3	-0.5	-0.6	1.1	1.2	1.4	-1.5	0.0
Reaction time trials on left	0.5	0.8	2.0	0.3	-0.3	-0.5	1.0	1.1	1.3	-1.4	0.0
Reaction time mean	2.2	3.1	4.3	-1.7	1.8	1.9	-1.9	-2.1	-1.9	1.9	0.0
Reaction time mean AUC	2.4	3.3	4.4	-1.9	1.9	2.0	-2.0	-2.1	-1.9	1.9	0.0
Median of all reaction times	1.5	2.0	3.0	-1.7	1.7	1.7	-1.5	-1.4	-1.2	1.3	0.0
Reaction time omissions	5.7	7.8	14.0	-2.2	2.8	2.8	-3.0	-3.7	-3.2	3.0	0.0
Reaction time false alarm rate	0.2	0.2	0.4	0.4	-0.6	-0.5	0.6	0.6	0.6	-0.0	0.0
Reaction time premature initiation rate	1.0	1.3	2.9	1.6	-1.7	-1.5	1.1	0.9	0.7	-0.6	0.0
Reaction time premature initiations	1.3	1.8	2.9	1.6	-1.7	-1.6	1.4	1.3	1.2	-1.2	0.0
Std. dev. reaction times	2.8	3.9	6.6	-1.3	1.6	1.7	-2.2	-2.6	-2.5	2.5	0.0
Reaction time trials completed	0.5	0.8	2.0	0.3	-0.3	-0.5	1.0	1.1	1.3	-1.4	0.0
Reaction time trials AUC	0.5	0.7	2.1	0.2	-0.2	-0.4	0.9	1.0	1.2	-1.4	0.0
Run reversals in cocaine runway, females	0.7	0.7	1.2	-1.0	0.8	0.9	-0.9	-0.6	-0.8	1.1	0.0
Run reversals in cocaine runway, males	2.4	2.3	3.9	-2.0	1.8	1.8	-1.6	-1.4	-1.2	1.3	0.0
Latency to leave start box in cocaine runway	0.7	0.7	1.0	0.9	-1.0	-0.9	0.9	0.9	0.9	-0.7	0.0
Latency to leave start box in cocaine runway, F	2.9	3.1	4.4	1.9	-2.1	-2.1	1.9	1.8	1.7	-1.6	0.0
Latency to leave start box in cocaine runway, M	2.0	1.9	2.6	-1.4	1.6	1.6	-1.5	-1.6	-1.3	1.3	0.0
Std. dev. time between licks in bursts	0.1	0.2	0.4	-0.0	-0.1	-0.1	0.4	0.4	0.7	-0.7	0.0
Total sessions with >9 infusions	0.3	0.4	1.4	1.2	-0.8	-0.7	0.3	-0.4	-0.2	-0.3	0.0
Short access day 1 total inactive lever presses	0.2	0.2	0.7	0.9	-0.6	-0.5	0.1	-0.4	-0.3	-0.1	0.0
Short access day 10 total inactive lever presses	0.2	0.2	0.7	0.0	0.1	0.1	-0.6	-0.5	-0.8	0.8	0.0
Short access day 1 total infusions	1.0	1.1	2.8	1.7	-1.5	-1.3	0.9	0.6	0.5	-0.6	0.0
Short access day 10 total infusions	1.3	1.5	3.5	1.9	-1.6	-1.6	1.2	0.6	0.7	-1.0	0.0
Short access total infusions	1.4	1.6	3.7	1.9	-1.7	-1.5	1.2	0.6	0.8	-1.1	0.0
Short access day 1 locomotion	0.1	0.1	0.3	0.4	-0.2	-0.0	-0.2	-0.3	-0.5	0.3	0.0
Short access day 10 total locomotion	1.6	1.7	3.1	-0.9	1.2	1.2	-1.5	-1.8	-1.6	1.4	0.0
Short access total locomotion	0.1	0.1	0.3	0.5	-0.4	-0.3	0.1	-0.0	-0.1	-0.2	0.0
One hour access (0.3 mA shock)	4.9	5.7	7.3	2.4	-2.6	-2.6	2.7	2.6	2.6	-2.3	0.0
Compulsive drug intake	0.6	0.6	1.3	-1.1	1.0	0.9	-0.8	-0.4	-0.6	0.9	0.0
One hour access (shock baseline)	5.7	6.6	8.9	3.0	-3.0	-3.0	2.8	2.4	2.5	-2.5	0.0
Social response proportion	0.4	0.5	0.9	-0.3	0.6	0.5	-0.7	-0.9	-1.0	0.9	0.0
Social responses	1.0	1.3	2.3	-0.8	1.1	1.0	-1.3	-1.3	-1.5	1.4	0.0
Social time	0.0	0.1	0.3	0.2	0.1	-0.0	-0.0	-0.6	-0.1	-0.2	0.0
Soleus weight	0.6	1.9	3.2	-1.8	1.7	1.6	-1.5	-1.1	-1.3	1.0	0.0
Bone: stiffness	0.0	0.0	0.1	-0.3	0.3	0.2	-0.0	0.2	0.1	-0.2	0.0
Tibialis anterior weight	5.2	17.8	35.5	-6.0	5.3	5.4	-4.4	-3.3	-3.1	3.0	0.0
Time to tail flick, vehicle, before self-admin	1.4	1.4	2.4	0.9	-1.1	-1.1	1.3	1.4	1.4	-1.5	0.0
Time to tail flick, vehicle, after self-admin	2.9	3.1	4.2	1.6	-1.9	-1.9	2.0	2.1	2.0	-1.9	0.0
Time to tail flick, test, before self-admin	0.2	0.2	0.6	0.3	0.1	-0.0	-0.5	-0.6	-0.8	0.8	0.0
Time to tail flick, test, after self-admin	0.2	0.3	0.9	0.9	-0.7	-0.7	0.4	0.1	0.1	-0.1	0.0
Delta time to tail flick, vehicle, before/after SA	1.0	1.0	1.3	1.1	-1.2	-1.1	1.1	1.0	1.1	-0.9	0.0
Delta time to tail flick, test, before/after SA	0.1	0.1	0.3	0.1	-0.0	0.0	-0.2	-0.3	-0.4	0.5	0.0
Tibia length	1.2	3.3	5.5	2.0	-2.1	-2.4	1.9	2.1	1.7	-1.3	0.0
Ambulatory time before self-admin	0.1	0.1	0.6	0.1	-0.2	-0.4	0.2	0.8	0.3	-0.2	0.0
Ambulatory time after self-admin	0.3	0.3	0.6	0.6	-0.6	-0.7	0.5	0.8	0.4	-0.2	0.0
Bone: tissue strength	1.6	1.5	2.6	1.6	-1.6	-1.6	1.3	1.2	0.9	-0.8	0.0
Total heroin consumption	0.1	0.1	0.2	-0.4	0.4	0.3	-0.0	-0.1	0.2	-0.3	0.0
Bone: trabecular number	0.8	1.3	1.7	1.0	-1.1	-1.2	1.3	1.3	1.3	-1.2	0.0
Bone: trabecular spacing	1.6	2.1	3.5	-1.1	1.3	1.4	-1.6	-1.9	-1.6	1.7	0.0
Bone: trabecular thickness	2.4	2.8	5.0	1.3	-1.5	-1.5	1.9	2.0	2.0	-2.2	0.0
Bone: trabecular tissue density	3.3	4.6	8.1	-1.5	2.1	2.1	-2.4	-2.9	-2.7	2.3	0.0
Water consumed over 24 hours	0.1	0.1	0.3	-0.5	0.4	0.4	-0.3	0.0	-0.2	0.1	0.0
Number of responses in last shaping day	0.1	0.1	0.2	0.1	-0.1	0.2	-0.3	-0.3	-0.4	0.5	0.0