Hub : Genes

Pag1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Brain gene expression Pag1 0.05 0.04 9.3e-04 0.03 0.02 0.02 0.03 6.6e-04 7.3e-03 5.9e-03 1.1e-03
2 NAcc gene expression Pag1 0.14 0.06 0.0e+00 0.16 0.16 0.17 0.17 1.3e-23 2.0e-23 1.1e-24 6.8e-25
3 BLA gene expression Pag1 0.09 0.06 7.3e-04 0.04 0.02 0.01 0.02 2.4e-03 3.3e-02 6.2e-02 2.0e-02
4 pVTA gene expression Pag1 0.14 0.08 6.2e-08 0.07 0.06 0.07 0.07 2.2e-06 1.7e-05 3.0e-06 2.8e-06
5 pVTA intron excision ratio chr2_93892679_93964594 0.09 0.06 1.2e-03 0.01 0.01 0.04 0.02 6.4e-02 2.7e-02 4.7e-04 4.8e-03
6 Liver mRNA stability Pag1 0.04 0.02 1.1e-04 0.02 0.02 0.02 0.01 3.1e-03 2.4e-03 2.5e-03 7.1e-03
7 RMTg gene expression Pag1 0.38 0.23 9.4e-04 0.04 0.04 0.01 0.05 2.5e-02 2.4e-02 1.9e-01 2.2e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7
Bone: apparent density1.22.13.51.31.31.51.4-0.21.91.9
Area under the delay curve0.81.01.6-0.9-1.0-0.9-0.90.5-1.3-1.2
BMI with tail1.03.36.6-1.5-2.1-1.7-1.62.6-1.6-1.3
BMI without tail1.54.78.9-1.9-2.5-2.1-2.03.0-1.9-1.4
Body weight1.25.212.4-2.0-2.6-2.2-2.23.5-1.5-1.2
Weight adjusted by age0.20.30.5-0.7-0.6-0.7-0.60.3-0.2-0.2
Bone surface1.93.57.21.71.51.61.61.02.52.7
Bone volume1.73.16.81.41.31.51.51.12.42.6
Breakpoint value in progressive ratio session0.80.91.2-1.0-1.1-1.1-1.10.9-0.7-0.8
Number of licking bursts0.20.40.60.70.60.60.6-0.20.60.8
Context. condit. distance diff. score0.10.10.6-0.10.20.20.2-0.8-0.2-0.4
Locomotion velocity, session 11.81.92.6-1.6-1.3-1.6-1.6-0.0-1.4-1.4
Locomotion distance, session 10.60.81.4-1.2-0.9-1.1-1.10.5-0.5-0.5
Locomotion velocity, session 22.22.53.1-1.8-1.7-1.7-1.71.0-1.5-1.4
Locomotion distance, session 21.01.42.3-1.5-1.3-1.4-1.41.1-0.5-0.4
Locomotion velocity, session 30.00.00.1-0.0-0.00.10.10.0-0.3-0.1
Locomotion distance, session 30.30.30.70.40.40.60.60.30.80.8
Stereotopy head waving bouts, day 30.20.21.0-0.4-0.4-0.3-0.31.00.20.3
Stereotopy head waving duration, day 30.60.71.0-0.8-0.9-0.8-0.81.0-0.8-0.6
Locomotion velocity, session 75.35.811.32.22.12.22.20.23.43.3
Locomotion distance, session 75.16.48.62.62.62.62.6-1.32.92.8
Stereotopy head waving bouts, day 70.80.91.1-1.1-1.0-1.0-1.00.8-0.8-0.7
Stereotopy head waving duration, day 71.21.41.7-1.2-1.3-1.3-1.30.9-1.2-1.2
Locomotion velocity, session 83.33.95.0-2.2-2.1-2.0-2.01.0-2.1-2.1
Locomotion distance, session 80.60.81.7-1.3-0.9-1.0-1.00.2-0.8-0.9
Degree of sensitization distance0.50.50.70.70.90.60.6-0.70.80.7
Degree of sensitization stereotypy1.82.02.4-1.5-1.5-1.5-1.50.8-1.5-1.3
Conditioned locomotion0.10.20.2-0.5-0.5-0.4-0.40.4-0.2-0.4
Cocaine response after cond. corrected0.80.91.10.91.01.01.0-1.10.80.8
Cocaine response after cond. not corrected1.41.72.01.21.41.41.4-1.41.21.1
Cocaine response before conditioning0.20.30.50.50.40.50.50.00.70.7
Saline control response0.60.82.20.50.10.50.51.51.01.2
Bone: connectivity density1.82.84.11.71.71.71.7-0.62.01.8
Bone: cortical apparent density0.71.01.7-0.9-0.9-1.0-1.00.0-1.2-1.3
Bone: cortical area0.71.14.8-0.7-1.1-0.8-0.82.2-0.20.2
Bone: cortical porosity0.10.10.20.10.20.00.0-0.20.30.5
Bone: cortical porosity0.00.00.1-0.3-0.1-0.3-0.3-0.10.00.2
Bone: cortical thickness0.91.54.0-1.2-1.4-1.2-1.22.0-0.7-0.2
Bone: cortical thickness5.36.27.6-2.6-2.7-2.7-2.72.2-2.5-2.1
Bone: cortical tissue density0.71.01.8-0.9-0.9-1.0-1.0-0.1-1.2-1.3
Condit. Reinf. active minus inactive responses4.95.48.1-2.6-2.6-2.6-2.62.8-1.3-1.1
Condit. Reinf. active-inactive response ratio6.16.59.4-2.8-2.9-2.9-2.93.1-1.4-1.3
Condit. Reinf. active responses3.74.57.8-2.3-2.3-2.4-2.42.8-0.9-0.8
Condit. Reinf. inactive responses0.00.10.1-0.3-0.2-0.3-0.30.3-0.1-0.0
Incentive salience index mean4.65.78.1-2.7-2.6-2.7-2.72.8-1.2-1.1
Condit. Reinf. lever presses1.82.53.6-1.9-1.7-1.9-1.91.5-1.0-1.0
Condit. Reinf. active minus inactive responses2.02.66.01.30.91.11.11.62.22.5
Condit. Reinf. active-inactive response ratio1.11.33.00.80.40.60.61.51.51.7
Condit. Reinf. active responses2.73.88.41.71.31.51.51.22.72.9
Condit. Reinf. inactive responses0.20.30.80.40.30.40.40.30.90.7
Condit. Reinf. lever presses1.21.73.81.10.60.80.81.41.72.0
Condit. Reinf. lever reinforcers received2.83.98.71.71.31.61.61.12.72.9
Conditioned reinforcement - actives4.17.010.82.62.42.72.7-0.33.23.3
Conditioned reinforcement - inactives0.20.30.70.40.30.50.50.20.80.7
Conditioned locomotion2.73.55.71.91.62.02.00.12.32.4
Patch foraging indifference point 0 sec0.50.91.60.90.91.31.2-0.60.70.6
Patch foraging indifference point AUC0.20.31.1-0.5-0.0-0.5-0.5-1.0-0.4-0.6
Delay disc. indifference point, 0s delay0.10.10.20.40.50.40.4-0.30.20.3
Delay disc. indifference point, 16s delay0.80.91.3-0.8-1.0-0.9-0.80.8-1.1-1.1
Delay disc. indifference point, 2s delay0.80.82.9-0.9-1.0-0.7-0.81.7-0.2-0.0
Delay disc. indifference point, 24s delay0.10.20.4-0.3-0.4-0.4-0.3-0.0-0.6-0.6
Delay disc. indifference point, 4s delay1.81.92.9-1.4-1.4-1.2-1.30.8-1.7-1.6
Delay disc. indifference point, 8s delay0.20.20.6-0.1-0.2-0.2-0.2-0.4-0.7-0.8
Indifference point function ln k0.10.20.9-0.1-0.40.10.01.0-0.4-0.3
Indifference point function log k0.10.20.9-0.1-0.40.10.01.0-0.4-0.3
Patch foraging total patch changes 0 sec0.20.40.80.60.60.90.9-0.60.30.2
Patch foraging total patch changes 12 sec0.40.52.10.30.70.60.6-1.50.2-0.1
Patch foraging total patch changes 18 sec0.50.81.2-1.1-0.9-0.9-0.80.1-1.0-1.0
Patch foraging total patch changes 24 sec0.20.31.60.10.50.40.4-1.3-0.0-0.2
Patch foraging total patch changes 6 sec0.10.10.3-0.3-0.0-0.1-0.1-0.5-0.4-0.6
Patch foraging time to switch 0 sec0.91.83.4-1.5-1.6-1.4-1.41.9-0.4-0.4
Patch foraging water rate 0 sec0.10.20.40.40.40.20.2-0.6-0.5-0.6
Patch foraging water rate 12 sec0.71.42.11.51.41.31.3-0.71.01.1
Patch foraging water rate 18 sec0.20.30.50.70.60.60.6-0.10.60.6
Patch foraging water rate 24 sec0.10.10.30.4-0.10.10.1-0.0-0.5-0.5
Patch foraging water rate 6 sec1.52.23.51.91.41.71.80.11.31.5
Seeking ratio, delayed vs. immediate footshock8.09.711.73.43.43.43.4-2.72.82.6
Distance traveled before self-admin0.60.82.0-0.8-1.0-0.6-0.61.4-1.0-0.7
Distance traveled after self-admin0.00.00.10.30.10.30.30.3-0.1-0.0
Extensor digitorum longus weight10.039.247.2-6.7-6.9-6.5-6.55.7-5.9-5.5
Bone: elastic displacement0.10.10.5-0.3-0.1-0.1-0.10.30.60.7
Bone: elastic work0.20.30.9-0.1-0.0-0.0-0.00.70.60.9
Bone: endosteal estimation0.71.64.80.70.20.50.62.21.51.7
Bone: endosteal perimeter0.30.71.31.00.60.60.70.41.11.1
Epididymis fat weight0.20.71.1-0.9-1.0-0.7-0.70.5-1.0-0.9
Delta time in closed arm before/after self-admin0.10.10.20.30.20.40.40.1-0.3-0.1
Delta time in open arm before/after self-admin0.10.10.20.20.30.30.30.00.50.4
Diff in mean of infusions in LGA sessions1.72.14.4-1.5-1.7-1.5-1.52.1-0.7-0.5
Delay discount exponential model param0.70.81.40.80.90.80.8-0.41.21.1
Extinction: sum of active levers before priming0.10.10.3-0.4-0.5-0.4-0.40.4-0.1-0.2
Active lever presses in extinction session 60.10.10.70.30.30.20.2-0.8-0.2-0.2
Bone: final force0.91.46.4-0.7-1.2-0.9-0.92.5-0.20.2
Bone: final moment0.71.16.3-0.3-0.8-0.4-0.42.50.20.6
Food consumed during 24 hour testing period1.82.42.9-1.6-1.7-1.6-1.61.6-1.4-1.2
Glucose1.42.32.9-1.5-1.7-1.5-1.51.4-1.5-1.2
Heart weight0.40.61.1-0.5-0.6-0.8-0.80.3-1.0-1.0
Delay discount hyperbolic model param1.11.21.61.11.11.01.0-0.71.31.2
Intermittent access intake day 1-15 change1.93.94.92.22.02.22.2-1.41.81.8
Intermittent access intake escalation2.34.76.12.52.32.42.4-1.71.91.9
Intermittent access intake escalation 25.76.67.92.82.72.82.8-1.92.52.4
Intermitt. access day 1 inactive lever presses0.62.44.1-1.4-1.5-1.5-1.50.6-2.0-2.0
Intermitt. access day 15 inactive lever presses0.71.55.2-0.7-0.1-0.5-0.5-2.3-1.2-1.7
Intermitt. access escalation Index0.81.12.8-0.8-0.5-0.8-0.8-1.0-1.4-1.7
Intermittent access day 1 total infusions2.13.45.01.61.91.81.8-1.42.22.1
Intermittent access day 15 total infusions6.59.711.13.23.23.33.3-2.23.23.1
Intermittent access terminal intake (last 3 days)7.29.410.23.23.23.23.2-2.53.13.1
Intermittent access total infusions5.16.16.92.52.52.52.5-1.82.62.6
Intermittent access day 1 locomotion0.70.91.20.60.90.90.9-0.91.11.0
Intermittent access day 15 total locomotion0.50.91.60.90.90.90.9-0.31.21.3
Intermittent access total locomotion1.62.02.41.31.41.41.4-1.21.51.5
Intermittent access standard deviation3.16.58.52.92.72.82.8-2.32.12.0
Left kidney weight0.00.10.20.50.30.30.3-0.4-0.4-0.3
Right kidney weight0.10.51.0-0.6-0.6-0.6-0.60.5-1.0-1.0
Cocaine induced anxiety0.40.61.0-0.7-0.8-0.7-0.70.2-1.0-1.0
Post-drug Anxiety1.71.92.4-1.3-1.6-1.4-1.41.4-1.3-1.2
Baseline Anxiety0.20.20.7-0.2-0.5-0.5-0.50.80.00.2
Tail length0.51.93.7-1.5-1.6-1.3-1.41.9-1.0-0.8
Length with tail0.31.44.3-1.0-1.3-1.1-1.12.1-0.4-0.3
Length without tail0.10.40.70.60.20.40.30.80.80.9
Times rat made contact with spout0.00.00.10.20.10.20.20.10.10.2
Lifetime Intake4.35.25.92.32.42.42.4-2.22.22.1
Liver weight, left0.60.92.2-0.9-1.1-1.0-1.01.5-0.5-0.3
Liver weight, right0.30.41.3-0.4-0.5-0.4-0.4-0.2-1.1-1.0
Locomotor activity0.10.10.6-0.1-0.30.10.10.8-0.30.0
Locomotor testing distance0.10.10.6-0.2-0.40.0-0.00.8-0.10.1
Locomotor testing rearing0.61.11.41.01.11.21.2-1.20.90.9
Locomotion in novel chamber0.91.22.2-1.2-1.3-1.1-1.11.5-0.6-0.5
Locomotion in novel chamber post-restriction0.10.10.3-0.10.1-0.2-0.1-0.5-0.5-0.4
Fecal boli incidents, locomotor time 10.10.10.4-0.6-0.4-0.4-0.4-0.0-0.2-0.4
Change in fecal boli incidents, locomotor task2.82.73.51.91.91.71.8-1.21.51.5
Time >=10cm from walls, locomotor time 11.11.21.81.01.01.21.1-0.21.31.3
Bouts of movement, locomotor time 10.80.93.30.50.50.50.5-1.8-0.8-1.0
Total resting periods, locomotor time 10.70.83.60.60.70.60.5-1.9-0.5-0.6
Rest time, locomotor task time 10.20.31.40.40.60.20.4-1.2-0.1-0.1
Distance moved, locomotor task time 10.10.20.8-0.2-0.5-0.2-0.20.9-0.3-0.2
Vertical activity count, locomotor time 10.30.73.8-0.2-0.60.1-0.11.90.30.6
Time >=10cm from walls, locomotor time 20.40.51.40.70.40.50.40.51.01.2
Bouts of movement, locomotor time 20.61.02.6-0.3-0.2-0.7-0.5-1.1-1.5-1.6
Total resting periods, locomotor time 20.61.12.9-0.3-0.2-0.6-0.5-1.1-1.6-1.7
Rest time, locomotor task time 20.20.20.7-0.3-0.3-0.3-0.3-0.4-0.8-0.7
Distance moved, locomotor task time 20.00.00.00.1-0.1-0.0-0.0-0.1-0.2-0.2
Vertical activity count, locomotor time 21.11.53.5-1.1-1.4-1.0-1.21.9-0.8-0.6
Light reinforcement 10.82.03.0-1.6-1.2-1.4-1.40.0-1.7-1.7
Light reinforcement 22.74.14.8-2.1-2.1-2.2-2.21.3-2.1-2.1
Bone: marrow area0.71.55.30.60.00.40.42.31.31.6
Bone: maximum diameter0.10.20.9-0.1-0.4-0.3-0.21.0-0.10.2
Bone: maximum force0.71.25.9-0.5-1.0-0.7-0.72.4-0.10.5
Bone: maximum moment0.61.05.5-0.1-0.6-0.2-0.22.30.40.9
Mean time between licks in bursts0.20.61.5-0.7-0.8-0.8-0.81.20.10.0
Mean num. licks in bursts0.10.20.4-0.5-0.4-0.3-0.40.3-0.5-0.6
Cd content in liver0.80.91.9-0.7-0.7-0.8-0.80.1-1.4-1.3
Co content in liver0.40.51.3-0.3-0.1-0.3-0.3-0.6-1.2-1.1
Cu content in liver3.03.64.71.92.12.02.0-2.21.51.4
Fe content in liver0.60.71.30.80.80.70.7-0.21.01.1
K content in liver0.80.71.20.91.00.80.8-1.10.70.4
Mg content in liver0.80.81.00.81.00.90.9-0.91.00.6
Mn content in liver0.10.10.8-0.10.30.10.1-0.90.2-0.2
Na content in liver0.70.81.51.21.10.80.8-0.80.70.6
Rb content in liver0.20.21.2-0.10.30.00.0-1.1-0.2-0.1
Se content in liver0.10.20.7-0.00.30.30.3-0.80.1-0.3
Sr content in liver0.20.10.40.10.20.40.40.10.60.3
Zn content in liver2.83.14.11.92.01.91.9-1.81.51.2
Bone: minimum diameter1.52.712.5-0.9-1.4-1.0-1.03.50.71.0
Time in familiar zone, hab. session 10.40.40.70.80.70.80.8-0.7-0.10.0
Time in novel zone, hab. session 10.10.10.1-0.4-0.1-0.3-0.3-0.30.0-0.0
Total zone transitions, hab. session 10.71.01.5-1.2-1.1-1.2-1.20.9-0.7-0.6
Total locomotion distance, hab. session 10.20.30.6-0.6-0.5-0.6-0.60.70.20.2
Locomotion velocity, hab. session 10.50.71.3-1.0-0.9-1.0-1.01.1-0.1-0.1
Time in familiar zone, hab. session 21.61.74.71.31.51.31.3-2.20.20.2
Time in novel zone, hab. session 20.70.72.9-0.7-0.9-0.7-0.71.70.10.2
Total zone transitions, hab. session 20.40.51.0-0.7-0.3-0.5-0.5-1.0-0.8-0.8
Total locomotion distance, hab. session 20.10.10.3-0.6-0.4-0.4-0.40.0-0.2-0.1
Locomotion velocity, hab. session 20.10.10.2-0.5-0.3-0.3-0.3-0.0-0.1-0.1
Novel to familiar place preference ratio0.10.10.5-0.1-0.2-0.1-0.10.70.10.2
Novelty place preference0.10.10.30.0-0.10.00.00.60.10.2
Time in novel zone, NPP test0.00.10.3-0.1-0.2-0.1-0.10.5-0.2-0.0
Total zone transitions, NPP test0.60.81.2-1.0-0.8-1.0-1.0-0.1-0.9-1.1
Total locomotion distance, NPP test0.20.30.7-0.8-0.6-0.7-0.70.3-0.2-0.2
Locomotion velocity, NPP test0.10.10.3-0.5-0.3-0.3-0.30.20.20.2
Intraocular pressure2.13.04.9-1.7-2.0-1.8-1.82.2-1.2-1.0
Delta distance traveled before/after self-admin2.83.03.82.01.81.81.8-0.91.91.8
Delta ambulatory time before/after self-admin2.83.44.02.01.91.91.9-1.32.01.9
Parametrial fat weight0.00.10.2-0.3-0.3-0.3-0.30.50.10.0
Pavlov. Cond. lever latency0.30.40.80.90.70.70.7-0.80.20.3
Pavlov. Cond. magazine entry latency0.20.30.6-0.7-0.6-0.6-0.60.8-0.2-0.1
Pavlov. Cond. change in total contacts2.22.43.3-1.8-1.8-1.6-1.61.8-1.1-0.9
Pavlov. Cond. index score0.60.71.3-1.1-1.0-0.9-0.90.7-0.6-0.6
Pavlov. Cond. latency score0.50.71.2-1.1-0.9-0.8-0.80.6-0.6-0.6
Pavlov. Cond. lever contacts0.40.51.2-0.9-0.8-0.6-0.61.1-0.0-0.1
Pavlov. Cond. magazine entry number0.70.91.41.21.01.01.0-0.60.90.8
Pavlov. Cond. intertrial magazine entries0.70.81.40.81.00.80.8-0.81.20.9
Pavlov. Cond. lever-magazine prob. diff.0.50.61.2-1.1-0.9-0.8-0.80.6-0.6-0.5
Pavlov. Cond. response bias0.60.71.2-1.1-1.0-0.9-0.91.1-0.4-0.3
Pavlov. Cond. lever latency0.91.31.9-1.4-1.0-1.1-1.1-0.1-1.3-1.4
Pavlov. Cond. magazine entry latency0.10.10.1-0.0-0.2-0.3-0.30.4-0.10.2
Pavlov. Cond. change in total contacts0.40.72.50.3-0.1-0.1-0.11.61.01.2
Pavlov. Cond. index score0.30.51.50.4-0.00.00.01.20.71.0
Pavlov. Cond. latency score0.40.51.20.60.20.20.20.90.81.1
Pavlov. Cond. lever contacts0.60.81.41.10.60.70.80.51.21.2
Pavlov. Cond. magazine entry number0.10.20.70.10.40.50.4-0.80.0-0.2
Pavlov. Cond. intertrial magazine entries0.10.10.4-0.5-0.4-0.3-0.30.6-0.0-0.1
Pavlov. Cond. lever-magazine prob. diff.0.30.41.00.50.10.10.11.00.81.0
Pavlov. Cond. response bias0.40.51.30.60.10.20.21.10.91.1
Time in closed arm before self-admin0.70.91.60.91.10.90.9-1.30.70.5
Time in closed arm after self-admin0.30.30.50.50.50.60.6-0.7-0.4-0.3
Time in open arm before self-admin0.20.21.1-0.2-0.2-0.0-0.01.00.30.6
Time in open arm after self-admin0.70.82.2-1.0-0.9-0.7-0.71.5-0.5-0.3
Bone: periosteal estimation1.02.111.3-0.3-0.9-0.5-0.53.40.71.2
Bone: periosteal perimeter0.20.31.40.2-0.10.00.11.20.40.7
Bone: post-yield work2.53.65.02.22.02.12.1-0.71.72.0
Progressive ratio test 1 active lever presses1.82.34.21.51.61.51.5-2.01.21.1
Progressive ratio test 1 breakpoint1.92.34.01.51.61.51.5-2.01.31.2
Progressive ratio test 1 inactive lever presses0.00.00.1-0.10.00.00.0-0.10.30.2
Progressive ratio test 2 active lever presses4.85.68.12.42.32.52.5-0.72.72.8
Progressive ratio test 2 breakpoint4.75.47.72.42.22.42.4-0.72.72.8
Progressive ratio test 2 inactive lever presses0.71.11.51.01.01.21.2-0.41.11.2
Incentive Sensitization - Responses2.53.57.41.61.51.71.70.52.52.7
Incentive Sensitization - Breakpoint2.73.67.21.61.51.81.80.52.52.7
Sum of active levers in priming session hrs 5-60.80.81.70.80.70.70.70.11.21.3
Progressive ratio0.50.81.21.10.91.01.0-1.1-0.3-0.2
Food seeking constrained by brief footshock3.13.87.1-2.0-2.3-2.0-2.02.7-1.1-0.9
Seeking ratio, punishment vs. effort2.02.95.0-1.9-2.0-1.9-1.92.2-0.4-0.4
Retroperitoneal fat weight0.10.40.6-0.8-0.7-0.7-0.70.2-0.5-0.5
Reaction time number correct0.50.92.00.50.30.60.71.21.21.4
Reaction time mean minus median1.84.56.7-2.0-1.6-2.3-2.3-1.0-2.5-2.6
Reaction time mean minus median AUC2.05.16.8-2.3-2.0-2.5-2.5-0.3-2.6-2.6
Reaction time num false alarms1.31.83.81.10.81.11.10.81.92.0
Reaction time num false alarms AUC1.21.83.71.10.91.31.20.51.91.9
Reaction time trials correct on left0.50.92.00.50.30.60.71.21.21.4
Reaction time trials on left0.40.81.80.40.20.50.61.21.11.3
Reaction time mean1.72.73.6-1.9-1.7-1.9-1.90.2-1.6-1.6
Reaction time mean AUC1.82.94.0-2.0-1.8-2.0-2.00.3-1.7-1.6
Median of all reaction times1.21.72.5-1.6-1.6-1.6-1.50.8-1.1-0.9
Reaction time omissions4.26.28.8-2.8-2.2-3.0-2.9-0.2-2.5-2.6
Reaction time false alarm rate0.20.30.40.60.50.60.6-0.30.70.6
Reaction time premature initiation rate1.41.92.61.61.51.61.6-1.50.80.6
Reaction time premature initiations1.12.02.81.61.51.71.6-0.81.31.1
Std. dev. reaction times1.63.04.4-1.7-1.4-1.9-1.8-0.9-2.1-2.1
Reaction time trials completed0.40.81.80.40.20.50.61.21.11.3
Reaction time trials AUC0.40.71.80.30.10.40.41.31.11.3
Run reversals in cocaine runway, females0.40.40.5-0.5-0.7-0.7-0.60.6-0.7-0.4
Run reversals in cocaine runway, males2.32.32.9-1.7-1.7-1.7-1.71.4-1.2-1.2
Latency to leave start box in cocaine runway0.91.01.31.11.11.01.0-1.10.90.8
Latency to leave start box in cocaine runway, F3.23.74.52.12.12.02.0-1.71.81.6
Latency to leave start box in cocaine runway, M2.32.12.7-1.6-1.5-1.6-1.60.6-1.4-1.4
Std. dev. time between licks in bursts0.10.20.80.1-0.20.10.10.90.50.5
Total sessions with >9 infusions1.72.13.91.31.61.51.5-2.01.10.9
Short access day 1 total inactive lever presses1.11.54.71.21.41.11.1-2.20.40.1
Short access day 10 total inactive lever presses0.10.30.9-0.2-0.3-0.3-0.3-0.1-0.8-0.9
Short access day 1 total infusions2.02.64.61.61.81.71.7-2.11.11.0
Short access day 10 total infusions2.63.34.81.72.01.91.9-2.21.71.5
Short access total infusions1.92.44.21.51.71.51.5-2.01.31.1
Short access day 1 locomotion0.10.10.10.30.20.40.4-0.4-0.10.0
Short access day 10 total locomotion0.20.50.7-0.7-0.6-0.7-0.7-0.3-0.8-0.8
Short access total locomotion0.20.20.30.50.50.60.6-0.30.40.5
One hour access (0.3 mA shock)6.17.09.12.62.62.82.8-1.33.03.0
Compulsive drug intake0.50.60.7-0.6-0.8-0.6-0.60.9-0.8-0.8
One hour access (shock baseline)6.49.913.33.13.13.23.2-1.73.53.6
Social response proportion0.50.61.0-0.8-0.7-0.8-0.70.1-0.9-1.0
Social responses1.01.32.1-1.2-1.1-1.0-1.00.3-1.4-1.4
Social time0.00.10.2-0.5-0.2-0.2-0.2-0.20.1-0.2
Soleus weight1.13.34.7-2.0-2.1-1.7-1.72.2-1.6-1.3
Bone: stiffness0.40.61.9-0.6-0.8-0.8-0.81.4-0.4-0.1
Tibialis anterior weight8.428.537.5-5.7-6.1-5.4-5.46.1-4.4-4.0
Time to tail flick, vehicle, before self-admin0.60.71.60.70.70.70.7-0.01.11.2
Time to tail flick, vehicle, after self-admin2.73.54.32.11.92.12.1-0.91.91.9
Time to tail flick, test, before self-admin0.10.10.3-0.30.20.10.1-0.5-0.4-0.5
Time to tail flick, test, after self-admin1.11.11.71.11.31.11.1-1.20.80.9
Delta time to tail flick, vehicle, before/after SA2.62.53.51.91.71.71.7-1.21.51.3
Delta time to tail flick, test, before/after SA0.00.00.00.1-0.1-0.2-0.2-0.1-0.2-0.1
Tibia length0.92.53.51.91.61.91.9-0.61.31.5
Ambulatory time before self-admin1.01.52.7-1.2-1.4-1.0-1.01.6-1.2-1.1
Ambulatory time after self-admin0.30.30.50.60.40.60.60.30.60.7
Bone: tissue strength2.93.03.92.02.01.81.7-1.81.41.3
Total heroin consumption0.20.20.60.10.10.30.30.60.80.7
Bone: trabecular number0.50.81.20.90.91.01.0-0.31.11.1
Bone: trabecular spacing1.11.52.5-1.2-1.1-1.3-1.3-0.1-1.3-1.6
Bone: trabecular thickness1.62.04.31.31.01.31.30.81.82.1
Bone: trabecular tissue density3.04.45.9-2.2-1.9-2.3-2.30.2-2.4-2.4
Water consumed over 24 hours0.20.20.5-0.4-0.6-0.4-0.40.7-0.5-0.3
Number of responses in last shaping day0.30.30.80.90.60.60.6-0.20.40.6