Hub : Genes

Pag1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Brain gene expression Pag1 0.05 0.04 9.3e-04 0.03 0.02 0.02 0.03 6.6e-04 7.3e-03 5.9e-03 1.1e-03
2 NAcc gene expression Pag1 0.14 0.06 0.0e+00 0.16 0.16 0.17 0.17 1.3e-23 2.0e-23 1.1e-24 6.8e-25
3 BLA gene expression Pag1 0.09 0.06 7.3e-04 0.04 0.02 0.01 0.03 2.4e-03 3.3e-02 6.2e-02 1.7e-02
4 pVTA gene expression Pag1 0.14 0.08 6.2e-08 0.07 0.06 0.07 0.07 2.2e-06 1.7e-05 3.1e-06 3.0e-06
5 pVTA intron excision ratio chr2_93892679_93964594 0.09 0.06 1.2e-03 0.01 0.01 0.04 0.02 6.4e-02 2.7e-02 4.7e-04 5.0e-03
6 RMTg gene expression Pag1 0.38 0.23 9.4e-04 0.04 0.04 0.01 0.04 2.5e-02 2.4e-02 1.8e-01 2.6e-02
7 Liver mRNA stability Pag1 0.04 0.02 1.1e-04 0.02 0.02 0.02 0.01 3.1e-03 2.4e-03 2.5e-03 7.1e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7
Bone: apparent density1.22.13.6-1.31.3-1.5-1.40.21.91.9
Area under the delay curve0.60.91.60.9-1.00.90.9-0.6-1.1-1.3
BMI with tail0.93.16.71.5-2.11.71.6-2.6-0.4-1.6
BMI without tail0.84.49.01.9-2.52.12.0-3.0-0.5-1.9
Body weight1.25.112.42.0-2.62.22.2-3.5-0.6-1.5
Weight adjusted by age0.10.30.50.7-0.60.70.6-0.3-0.4-0.2
Bone surface1.93.78.2-1.71.5-1.6-1.6-1.02.92.5
Bone volume1.63.16.8-1.41.3-1.5-1.5-1.12.62.4
Breakpoint value in progressive ratio session0.51.01.21.0-1.11.11.1-0.9-0.9-0.7
Number of licking bursts0.10.41.0-0.70.6-0.6-0.60.21.00.6
Context. condit. distance diff. score0.10.10.60.10.2-0.2-0.20.8-0.1-0.2
Locomotion velocity, session 11.82.02.91.6-1.31.61.60.0-1.7-1.4
Locomotion distance, session 10.60.81.41.2-0.91.11.1-0.5-0.7-0.5
Locomotion velocity, session 22.12.53.11.8-1.71.71.7-1.1-1.5-1.5
Locomotion distance, session 21.01.52.31.5-1.31.41.4-1.1-0.8-0.5
Locomotion velocity, session 30.00.00.10.0-0.0-0.1-0.1-0.0-0.2-0.3
Locomotion distance, session 30.30.30.8-0.40.4-0.6-0.6-0.30.90.8
Stereotopy head waving bouts, day 30.20.20.90.4-0.40.30.3-1.0-0.10.2
Stereotopy head waving duration, day 30.50.71.00.8-0.90.80.8-1.0-0.7-0.8
Locomotion velocity, session 75.05.411.3-2.22.1-2.2-2.2-0.22.93.4
Locomotion distance, session 74.96.28.6-2.62.6-2.6-2.61.32.62.9
Stereotopy head waving bouts, day 70.70.81.11.1-1.01.01.0-0.8-0.6-0.8
Stereotopy head waving duration, day 71.11.41.71.2-1.31.31.3-0.9-0.9-1.2
Locomotion velocity, session 83.23.95.02.2-2.12.02.0-1.0-2.1-2.1
Locomotion distance, session 80.60.81.71.3-0.91.01.0-0.2-0.8-0.8
Degree of sensitization distance0.40.50.7-0.70.9-0.6-0.60.70.40.8
Degree of sensitization stereotypy1.71.92.41.5-1.51.51.5-0.8-1.1-1.5
Conditioned locomotion0.10.20.20.5-0.50.40.4-0.4-0.4-0.2
Cocaine response after cond. corrected0.60.91.1-0.91.0-1.0-1.01.10.50.8
Cocaine response after cond. not corrected1.11.62.0-1.21.4-1.4-1.41.40.71.2
Cocaine response before conditioning0.20.20.5-0.50.4-0.5-0.5-0.00.50.7
Saline control response0.60.92.2-0.50.1-0.5-0.5-1.51.51.0
Bone: connectivity density1.82.94.1-1.71.7-1.7-1.70.62.02.0
Bone: cortical apparent density0.60.91.50.9-0.91.01.0-0.0-1.2-1.2
Bone: cortical area0.71.24.80.7-1.10.80.8-2.20.5-0.2
Bone: cortical porosity0.00.00.1-0.10.2-0.0-0.00.20.20.3
Bone: cortical porosity0.00.00.10.3-0.10.30.30.2-0.10.0
Bone: cortical thickness0.91.54.01.2-1.41.21.2-2.0-0.2-0.7
Bone: cortical thickness5.16.27.62.6-2.72.72.7-2.2-2.0-2.5
Bone: cortical tissue density0.60.91.60.9-0.91.01.00.1-1.3-1.2
Condit. Reinf. active minus inactive responses4.95.58.12.6-2.62.62.6-2.8-1.4-1.3
Condit. Reinf. active-inactive response ratio6.26.69.42.8-2.82.92.9-3.1-1.6-1.4
Condit. Reinf. active responses3.64.67.82.3-2.32.42.4-2.8-1.0-0.9
Condit. Reinf. inactive responses0.00.10.10.3-0.20.30.3-0.30.2-0.1
Incentive salience index mean4.55.88.12.7-2.62.72.7-2.8-1.4-1.2
Condit. Reinf. lever presses1.72.53.61.9-1.71.91.9-1.5-1.0-1.0
Condit. Reinf. active minus inactive responses1.72.65.5-1.30.9-1.1-1.1-1.62.32.2
Condit. Reinf. active-inactive response ratio0.81.33.4-0.80.4-0.6-0.6-1.51.81.5
Condit. Reinf. active responses2.53.67.5-1.71.3-1.5-1.5-1.22.62.7
Condit. Reinf. inactive responses0.20.20.8-0.40.3-0.4-0.4-0.30.50.9
Condit. Reinf. lever presses1.01.52.8-1.10.6-0.8-0.8-1.41.71.7
Condit. Reinf. lever reinforcers received2.63.67.4-1.71.3-1.6-1.6-1.12.62.7
Conditioned reinforcement - actives1.87.212.1-2.62.4-2.7-2.70.33.53.2
Conditioned reinforcement - inactives0.10.30.7-0.40.4-0.5-0.5-0.20.70.8
Conditioned locomotion2.53.87.4-1.91.6-2.0-2.0-0.12.72.3
Patch foraging indifference point 0 sec0.30.81.6-0.90.9-1.3-1.20.60.50.7
Patch foraging indifference point AUC0.20.41.20.5-0.00.50.51.0-1.1-0.4
Delay disc. indifference point, 0s delay0.10.10.2-0.40.5-0.4-0.40.30.40.2
Delay disc. indifference point, 16s delay0.60.91.30.8-1.00.90.8-0.8-1.1-1.1
Delay disc. indifference point, 2s delay0.70.82.90.9-1.00.70.8-1.70.0-0.2
Delay disc. indifference point, 24s delay0.10.20.40.3-0.40.40.30.0-0.6-0.6
Delay disc. indifference point, 4s delay1.71.82.91.4-1.41.21.3-0.8-1.3-1.7
Delay disc. indifference point, 8s delay0.10.20.60.1-0.20.20.20.4-0.8-0.7
Indifference point function ln k0.10.20.90.1-0.4-0.1-0.0-1.00.3-0.4
Indifference point function log k0.10.20.90.1-0.4-0.1-0.0-1.00.3-0.4
Patch foraging total patch changes 0 sec0.10.40.8-0.60.6-0.9-0.90.60.00.3
Patch foraging total patch changes 12 sec0.40.52.1-0.30.7-0.6-0.61.5-0.50.2
Patch foraging total patch changes 18 sec0.40.92.11.1-0.90.90.8-0.1-1.5-1.0
Patch foraging total patch changes 24 sec0.10.31.6-0.10.5-0.4-0.41.3-0.4-0.0
Patch foraging total patch changes 6 sec0.10.20.70.3-0.00.10.10.5-0.9-0.4
Patch foraging time to switch 0 sec0.51.83.41.5-1.61.41.4-1.9-0.3-0.4
Patch foraging water rate 0 sec0.10.20.4-0.40.3-0.2-0.20.6-0.5-0.5
Patch foraging water rate 12 sec0.41.52.1-1.51.4-1.3-1.30.71.21.0
Patch foraging water rate 18 sec0.20.40.7-0.70.6-0.6-0.60.10.80.6
Patch foraging water rate 24 sec0.10.10.3-0.4-0.1-0.1-0.10.0-0.4-0.5
Patch foraging water rate 6 sec1.62.33.5-1.91.4-1.7-1.8-0.11.81.3
Seeking ratio, delayed vs. immediate footshock6.99.811.7-3.43.4-3.4-3.42.72.72.8
Distance traveled before self-admin0.30.82.00.8-1.00.60.6-1.4-0.0-1.0
Distance traveled after self-admin0.10.10.4-0.30.1-0.3-0.3-0.30.6-0.1
Extensor digitorum longus weight9.638.147.26.7-6.96.56.5-5.7-4.8-5.9
Bone: elastic displacement0.10.10.30.3-0.10.10.1-0.30.40.6
Bone: elastic work0.20.20.50.1-0.00.00.0-0.70.70.6
Bone: endosteal estimation0.81.95.4-0.70.2-0.5-0.6-2.22.31.5
Bone: endosteal perimeter0.30.82.0-1.00.6-0.6-0.7-0.41.41.1
Epididymis fat weight0.10.71.10.9-1.00.70.7-0.5-0.8-1.0
Delta time in closed arm before/after self-admin0.10.10.2-0.30.2-0.4-0.4-0.10.5-0.3
Delta time in open arm before/after self-admin0.10.10.2-0.20.3-0.3-0.3-0.00.40.5
Diff in mean of infusions in LGA sessions1.22.14.41.5-1.71.51.5-2.1-0.5-0.7
Delay discount exponential model param0.60.71.4-0.80.9-0.8-0.80.41.11.2
Extinction: sum of active levers before priming0.10.20.30.4-0.50.40.4-0.4-0.4-0.1
Active lever presses in extinction session 60.10.10.7-0.30.3-0.2-0.20.8-0.1-0.2
Bone: final force0.91.46.40.7-1.20.90.9-2.50.5-0.2
Bone: final moment0.71.26.30.3-0.80.40.4-2.51.00.2
Food consumed during 24 hour testing period1.22.52.91.6-1.71.61.6-1.6-1.3-1.4
Glucose1.42.32.91.5-1.71.51.5-1.4-1.2-1.5
Heart weight0.40.61.10.5-0.60.80.8-0.3-1.0-1.0
Delay discount hyperbolic model param0.91.21.6-1.11.1-1.0-1.00.71.21.3
Intermittent access intake day 1-15 change0.74.04.9-2.22.0-2.2-2.21.42.01.8
Intermittent access intake escalation0.94.86.1-2.52.3-2.4-2.41.72.01.9
Intermittent access intake escalation 23.96.67.9-2.82.7-2.8-2.81.92.42.5
Intermitt. access day 1 inactive lever presses0.22.43.91.4-1.51.51.5-0.6-1.9-2.0
Intermitt. access day 15 inactive lever presses0.31.95.20.7-0.10.50.52.3-2.3-1.2
Intermitt. access escalation Index0.41.23.30.8-0.50.80.81.0-1.8-1.4
Intermittent access day 1 total infusions1.03.15.0-1.61.9-1.8-1.81.41.72.2
Intermittent access day 15 total infusions3.99.711.1-3.23.2-3.3-3.32.23.03.2
Intermittent access terminal intake (last 3 days)5.29.210.2-3.23.2-3.2-3.22.52.83.1
Intermittent access total infusions5.05.96.9-2.52.5-2.5-2.51.82.32.6
Intermittent access day 1 locomotion0.40.81.2-0.60.9-0.9-0.90.90.81.1
Intermittent access day 15 total locomotion0.20.91.6-0.90.9-0.9-0.90.31.21.2
Intermittent access total locomotion1.51.82.4-1.31.4-1.4-1.41.21.21.5
Intermittent access standard deviation1.36.68.5-2.92.7-2.8-2.82.32.22.1
Left kidney weight0.00.10.2-0.50.3-0.3-0.30.4-0.1-0.4
Right kidney weight0.10.41.00.6-0.60.60.6-0.5-0.6-1.0
Cocaine induced anxiety0.20.61.00.7-0.80.70.7-0.2-1.0-1.0
Post-drug Anxiety1.61.82.41.3-1.61.41.4-1.4-1.0-1.3
Baseline Anxiety0.10.20.70.2-0.50.50.5-0.80.30.0
Tail length0.41.93.71.5-1.61.31.4-1.9-0.8-1.0
Length with tail0.31.44.31.0-1.31.11.1-2.1-0.4-0.4
Length without tail0.10.40.7-0.60.2-0.4-0.3-0.80.80.8
Times rat made contact with spout0.00.00.2-0.20.1-0.2-0.2-0.10.40.1
Lifetime Intake4.05.05.9-2.32.4-2.4-2.42.21.82.2
Liver weight, left0.50.92.20.9-1.11.01.0-1.5-0.2-0.5
Liver weight, right0.30.51.30.4-0.50.40.40.1-1.1-1.1
Locomotor activity0.10.10.60.1-0.3-0.1-0.1-0.80.5-0.3
Locomotor testing distance0.10.10.60.2-0.4-0.00.0-0.80.4-0.1
Locomotor testing rearing0.31.11.4-1.01.1-1.2-1.21.20.80.9
Locomotion in novel chamber0.91.22.21.2-1.31.11.1-1.5-0.3-0.6
Locomotion in novel chamber post-restriction0.00.10.30.10.10.20.10.5-0.4-0.5
Fecal boli incidents, locomotor time 10.10.20.40.6-0.40.40.40.0-0.6-0.2
Change in fecal boli incidents, locomotor task2.72.83.5-1.91.9-1.7-1.81.21.71.5
Time >=10cm from walls, locomotor time 11.01.32.3-1.01.0-1.2-1.10.21.51.3
Bouts of movement, locomotor time 10.60.83.3-0.50.5-0.5-0.51.8-0.9-0.8
Total resting periods, locomotor time 10.70.83.6-0.60.7-0.6-0.51.9-0.6-0.5
Rest time, locomotor task time 10.20.31.4-0.40.6-0.2-0.41.2-0.2-0.1
Distance moved, locomotor task time 10.10.20.80.2-0.50.20.2-0.90.1-0.3
Vertical activity count, locomotor time 10.10.83.80.2-0.6-0.10.1-1.91.00.3
Time >=10cm from walls, locomotor time 20.20.61.7-0.70.4-0.5-0.4-0.51.31.0
Bouts of movement, locomotor time 20.30.92.30.3-0.20.70.51.1-1.4-1.5
Total resting periods, locomotor time 20.21.02.60.3-0.20.60.51.1-1.5-1.6
Rest time, locomotor task time 20.10.30.70.3-0.30.30.30.4-0.7-0.8
Distance moved, locomotor task time 20.00.00.0-0.1-0.10.00.00.1-0.0-0.2
Vertical activity count, locomotor time 20.61.43.51.1-1.41.01.2-1.9-0.2-0.8
Light reinforcement 10.52.24.71.6-1.21.41.4-0.0-2.2-1.7
Light reinforcement 21.84.04.82.1-2.12.22.2-1.3-1.9-2.1
Bone: marrow area0.71.85.2-0.60.0-0.4-0.4-2.32.21.3
Bone: maximum diameter0.10.20.90.1-0.40.30.2-1.00.7-0.1
Bone: maximum force0.61.25.90.5-1.00.70.7-2.40.6-0.1
Bone: maximum moment0.51.05.50.1-0.60.20.2-2.31.10.4
Mean time between licks in bursts0.10.61.50.7-0.80.80.8-1.2-0.40.1
Mean num. licks in bursts0.10.20.40.5-0.40.30.4-0.3-0.6-0.5
Cd content in liver0.80.81.90.7-0.70.80.8-0.1-1.3-1.4
Co content in liver0.40.41.30.3-0.10.30.30.6-1.0-1.2
Cu content in liver3.03.54.7-1.92.1-2.0-2.02.21.31.5
Fe content in liver0.50.71.3-0.80.8-0.7-0.70.21.11.0
K content in liver0.70.71.2-0.91.0-0.8-0.81.10.40.7
Mg content in liver0.70.81.0-0.81.0-0.9-0.90.90.61.0
Mn content in liver0.10.10.80.10.3-0.1-0.10.9-0.20.2
Na content in liver0.80.91.5-1.21.1-0.8-0.80.81.10.7
Rb content in liver0.20.21.20.10.3-0.0-0.01.1-0.4-0.2
Se content in liver0.10.10.70.00.3-0.3-0.30.8-0.10.1
Sr content in liver0.20.10.4-0.10.2-0.4-0.4-0.10.50.6
Zn content in liver2.63.14.1-1.92.0-1.9-1.91.81.01.5
Bone: minimum diameter1.42.712.40.9-1.41.01.0-3.51.20.7
Time in familiar zone, hab. session 10.40.40.7-0.80.7-0.8-0.80.70.4-0.1
Time in novel zone, hab. session 10.10.10.30.4-0.10.30.30.3-0.50.0
Total zone transitions, hab. session 10.81.11.51.2-1.11.21.2-0.9-0.9-0.7
Total locomotion distance, hab. session 10.20.30.60.6-0.50.60.6-0.7-0.00.2
Locomotion velocity, hab. session 10.50.71.31.0-0.91.01.0-1.1-0.3-0.1
Time in familiar zone, hab. session 21.51.74.7-1.31.5-1.3-1.32.20.20.2
Time in novel zone, hab. session 20.70.72.90.7-0.90.70.7-1.70.20.1
Total zone transitions, hab. session 20.40.51.00.7-0.30.50.51.0-1.0-0.8
Total locomotion distance, hab. session 20.10.10.30.6-0.40.40.4-0.0-0.3-0.2
Locomotion velocity, hab. session 20.10.10.20.5-0.30.30.30.0-0.2-0.1
Novel to familiar place preference ratio0.10.10.50.1-0.20.10.1-0.70.50.1
Novelty place preference0.10.10.3-0.0-0.1-0.0-0.0-0.60.50.1
Time in novel zone, NPP test0.10.10.30.1-0.20.10.1-0.50.3-0.2
Total zone transitions, NPP test0.60.91.51.0-0.81.01.00.1-1.2-0.9
Total locomotion distance, NPP test0.20.30.70.8-0.60.70.7-0.3-0.4-0.2
Locomotion velocity, NPP test0.10.10.30.5-0.30.30.3-0.2-0.10.2
Intraocular pressure1.82.94.91.7-2.01.81.8-2.2-0.9-1.2
Delta distance traveled before/after self-admin2.83.13.8-2.01.8-1.8-1.80.91.91.9
Delta ambulatory time before/after self-admin2.03.44.0-2.01.9-1.9-1.91.31.82.0
Parametrial fat weight0.00.10.20.3-0.30.30.3-0.5-0.10.1
Pavlov. Cond. lever latency0.30.40.8-0.90.7-0.7-0.70.80.20.2
Pavlov. Cond. magazine entry latency0.20.30.60.7-0.60.60.6-0.80.0-0.2
Pavlov. Cond. change in total contacts2.22.33.31.8-1.81.61.6-1.8-0.8-1.1
Pavlov. Cond. index score0.60.71.31.1-1.00.90.9-0.7-0.5-0.6
Pavlov. Cond. latency score0.50.61.21.1-0.90.80.8-0.6-0.6-0.6
Pavlov. Cond. lever contacts0.40.51.20.9-0.80.60.6-1.1-0.0-0.0
Pavlov. Cond. magazine entry number0.70.91.4-1.21.0-1.0-1.00.60.60.9
Pavlov. Cond. intertrial magazine entries0.60.81.4-0.81.0-0.8-0.80.80.61.2
Pavlov. Cond. lever-magazine prob. diff.0.50.61.21.1-0.90.80.8-0.6-0.5-0.6
Pavlov. Cond. response bias0.60.71.21.1-1.00.90.9-1.1-0.1-0.4
Pavlov. Cond. lever latency0.81.21.81.4-1.01.11.10.1-1.2-1.3
Pavlov. Cond. magazine entry latency0.00.10.10.0-0.20.30.3-0.40.0-0.1
Pavlov. Cond. change in total contacts0.30.72.5-0.3-0.10.10.1-1.61.01.0
Pavlov. Cond. index score0.30.41.5-0.4-0.0-0.0-0.0-1.20.80.7
Pavlov. Cond. latency score0.30.40.9-0.60.2-0.2-0.2-0.90.90.8
Pavlov. Cond. lever contacts0.50.71.4-1.10.6-0.7-0.8-0.51.01.2
Pavlov. Cond. magazine entry number0.10.20.7-0.10.4-0.5-0.40.8-0.20.0
Pavlov. Cond. intertrial magazine entries0.10.10.40.5-0.40.30.3-0.6-0.0-0.0
Pavlov. Cond. lever-magazine prob. diff.0.20.31.0-0.50.1-0.1-0.1-1.00.80.8
Pavlov. Cond. response bias0.40.51.3-0.60.1-0.2-0.2-1.10.90.9
Time in closed arm before self-admin0.50.91.6-0.91.1-0.9-0.91.30.30.7
Time in closed arm after self-admin0.20.30.5-0.50.5-0.6-0.60.70.2-0.4
Time in open arm before self-admin0.20.31.10.2-0.20.00.0-1.00.70.3
Time in open arm after self-admin0.70.82.21.0-0.90.70.7-1.5-0.2-0.5
Bone: periosteal estimation1.02.311.30.3-0.90.50.5-3.41.70.7
Bone: periosteal perimeter0.20.41.4-0.2-0.1-0.0-0.1-1.21.10.4
Bone: post-yield work2.13.75.0-2.22.0-2.1-2.10.72.11.7
Progressive ratio test 1 active lever presses1.22.24.2-1.51.6-1.5-1.52.00.81.2
Progressive ratio test 1 breakpoint1.32.24.0-1.51.6-1.5-1.52.00.81.3
Progressive ratio test 1 inactive lever presses0.00.00.10.10.0-0.0-0.00.1-0.00.3
Progressive ratio test 2 active lever presses4.05.68.1-2.42.3-2.5-2.50.72.82.7
Progressive ratio test 2 breakpoint4.25.37.5-2.42.2-2.4-2.40.72.72.7
Progressive ratio test 2 inactive lever presses0.41.11.7-1.01.0-1.2-1.20.41.31.1
Incentive Sensitization - Responses1.33.57.3-1.61.5-1.7-1.7-0.52.72.5
Incentive Sensitization - Breakpoint1.63.67.2-1.61.5-1.8-1.8-0.52.72.5
Sum of active levers in priming session hrs 5-60.70.71.5-0.80.7-0.7-0.7-0.11.11.2
Progressive ratio0.30.81.2-1.10.9-1.0-1.01.10.3-0.3
Food seeking constrained by brief footshock3.03.77.12.0-2.32.02.0-2.7-0.8-1.1
Seeking ratio, punishment vs. effort1.32.95.01.9-2.01.91.9-2.2-0.8-0.4
Retroperitoneal fat weight0.10.40.60.8-0.70.70.7-0.3-0.6-0.5
Reaction time number correct0.20.91.9-0.50.3-0.6-0.7-1.21.41.2
Reaction time mean minus median0.85.010.42.0-1.62.32.30.9-3.2-2.5
Reaction time mean minus median AUC0.85.610.12.3-2.02.52.50.3-3.2-2.6
Reaction time num false alarms1.11.84.1-1.10.8-1.1-1.1-0.82.01.9
Reaction time num false alarms AUC0.81.83.8-1.10.9-1.3-1.2-0.51.91.9
Reaction time trials correct on left0.20.91.9-0.50.3-0.6-0.7-1.21.41.2
Reaction time trials on left0.20.71.6-0.40.2-0.5-0.6-1.21.31.1
Reaction time mean1.32.83.61.9-1.71.91.9-0.2-1.9-1.6
Reaction time mean AUC1.33.14.02.0-1.82.02.0-0.3-1.9-1.7
Median of all reaction times1.11.82.51.6-1.61.61.5-0.8-1.1-1.1
Reaction time omissions4.47.113.22.8-2.23.02.90.2-3.6-2.5
Reaction time false alarm rate0.20.30.5-0.60.5-0.6-0.60.30.70.7
Reaction time premature initiation rate1.32.02.6-1.61.5-1.6-1.61.50.70.8
Reaction time premature initiations0.72.02.8-1.61.5-1.7-1.60.81.21.3
Std. dev. reaction times1.03.46.71.7-1.41.91.80.9-2.6-2.1
Reaction time trials completed0.20.71.6-0.40.2-0.5-0.6-1.21.31.1
Reaction time trials AUC0.20.71.8-0.30.1-0.4-0.4-1.31.21.1
Run reversals in cocaine runway, females0.30.40.50.5-0.70.70.6-0.6-0.3-0.7
Run reversals in cocaine runway, males2.12.32.91.7-1.71.71.7-1.4-1.2-1.2
Latency to leave start box in cocaine runway0.71.01.3-1.11.1-1.0-1.01.10.80.9
Latency to leave start box in cocaine runway, F3.03.84.5-2.12.1-2.0-2.01.71.81.8
Latency to leave start box in cocaine runway, M2.32.22.71.6-1.51.61.6-0.6-1.6-1.4
Std. dev. time between licks in bursts0.10.20.8-0.1-0.2-0.1-0.1-0.90.50.5
Total sessions with >9 infusions1.62.03.9-1.31.6-1.5-1.52.00.51.1
Short access day 1 total inactive lever presses0.81.54.7-1.21.4-1.1-1.12.2-0.10.4
Short access day 10 total inactive lever presses0.00.20.70.2-0.30.30.30.1-0.6-0.8
Short access day 1 total infusions1.32.64.6-1.61.8-1.7-1.72.10.71.1
Short access day 10 total infusions2.03.24.8-1.72.0-1.9-1.92.21.21.7
Short access total infusions1.62.34.2-1.51.7-1.5-1.52.00.61.3
Short access day 1 locomotion0.00.10.1-0.30.2-0.4-0.40.40.1-0.1
Short access day 10 total locomotion0.10.51.10.7-0.60.70.70.3-1.1-0.8
Short access total locomotion0.20.20.3-0.50.5-0.6-0.60.30.50.4
One hour access (0.3 mA shock)5.97.09.4-2.62.6-2.8-2.81.33.13.0
Compulsive drug intake0.30.50.70.6-0.80.60.6-0.9-0.3-0.8
One hour access (shock baseline)3.79.712.5-3.13.1-3.2-3.21.73.53.5
Social response proportion0.50.61.20.8-0.70.80.7-0.1-1.1-0.9
Social responses1.01.32.11.2-1.11.01.0-0.3-1.5-1.4
Social time0.10.10.50.5-0.20.20.20.2-0.70.1
Soleus weight1.13.34.82.0-2.11.71.7-2.2-1.2-1.6
Bone: stiffness0.30.61.90.6-0.80.80.8-1.4-0.2-0.4
Tibialis anterior weight8.027.637.55.7-6.15.45.4-6.1-3.2-4.4
Time to tail flick, vehicle, before self-admin0.50.61.4-0.70.7-0.7-0.70.01.21.1
Time to tail flick, vehicle, after self-admin1.83.64.3-2.11.9-2.1-2.10.92.11.9
Time to tail flick, test, before self-admin0.10.10.30.30.2-0.1-0.10.5-0.4-0.4
Time to tail flick, test, after self-admin1.01.11.7-1.11.3-1.1-1.11.20.50.8
Delta time to tail flick, vehicle, before/after SA2.42.53.5-1.91.7-1.7-1.71.21.31.5
Delta time to tail flick, test, before/after SA0.00.00.1-0.1-0.20.20.20.1-0.3-0.2
Tibia length0.92.63.5-1.91.6-1.9-1.90.71.71.3
Ambulatory time before self-admin0.51.42.71.2-1.41.01.0-1.6-0.4-1.2
Ambulatory time after self-admin0.30.41.3-0.60.4-0.6-0.6-0.31.10.6
Bone: tissue strength2.93.03.9-2.02.0-1.8-1.71.81.31.4
Total heroin consumption0.20.20.6-0.10.1-0.3-0.3-0.60.70.8
Bone: trabecular number0.50.91.4-0.90.9-1.0-1.00.31.21.1
Bone: trabecular spacing1.11.53.11.2-1.11.31.30.1-1.8-1.3
Bone: trabecular thickness1.42.04.0-1.31.0-1.3-1.3-0.82.01.8
Bone: trabecular tissue density2.84.99.52.2-1.92.32.3-0.2-3.1-2.4
Water consumed over 24 hours0.10.20.50.4-0.60.40.4-0.7-0.0-0.5
Number of responses in last shaping day0.30.40.8-0.90.6-0.6-0.60.20.60.4