Hub : Genes

Zfp395

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Liver	gene expression	Zfp395	0.02	0.02	3.7e-03	0.02	0.01	0	0.01	5.1e-03	5.6e-02	7.9e-02	4.2e-02
2	pVTA	gene expression	Zfp395	0.11	0.07	2.4e-03	0.02	0.06	0.03	0.03	4.5e-02	1.4e-03	1.4e-02	1.4e-02
3	Adipose	gene expression	Zfp395	0.11	0.07	5.3e-07	0.05	0.05	0.05	0.05	2.9e-06	3.8e-06	5.3e-06	5.0e-06
4	Adipose	isoform ratio	XM_039093334.1	0.03	0.02	2.3e-03	0.03	0.02	0.03	0.02	5.4e-04	5.5e-03	7.2e-04	1.5e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bone: apparent density	0.5	0.8	1.2	1.0	-1.0	-0.2	1.1
Area under the delay curve	3.8	4.1	8.4	-2.5	1.2	-0.2	-2.9
BMI with tail	0.6	1.9	4.7	-2.2	0.5	0.3	-1.5
BMI without tail	0.5	1.0	2.4	0.6	-1.5	-1.1	-0.2
Body weight	0.8	3.6	9.1	-3.0	1.5	1.5	-0.7
Weight adjusted by age	2.9	3.3	6.4	-1.1	2.1	2.5	1.1
Bone surface	0.2	0.3	0.6	0.7	-0.2	-0.1	0.8
Bone volume	0.0	0.1	0.1	0.3	-0.3	-0.3	0.0
Breakpoint value in progressive ratio session	1.2	1.3	3.5	-0.8	-0.4	-0.9	-1.9
Number of licking bursts	0.4	0.5	1.0	-0.7	-0.7	-0.4	-1.0
Context. condit. distance diff. score	3.7	4.5	7.1	1.3	-2.7	-2.6	-1.6
Locomotion velocity, session 1	0.1	0.1	0.2	-0.3	0.2	-0.5	-0.5
Locomotion distance, session 1	0.1	0.2	0.5	-0.0	0.7	-0.2	-0.3
Locomotion velocity, session 2	0.4	0.5	1.0	-0.5	0.8	-0.3	-1.0
Locomotion distance, session 2	0.1	0.2	0.6	0.3	0.8	0.0	0.3
Locomotion velocity, session 3	0.5	0.6	1.1	-1.0	0.5	1.0	0.2
Locomotion distance, session 3	0.3	0.3	0.8	-0.9	-0.1	0.2	-0.6
Stereotopy head waving bouts, day 3	1.0	1.2	2.2	0.3	0.5	1.5	1.5
Stereotopy head waving duration, day 3	1.6	2.0	3.6	-0.8	1.6	1.9	1.0
Locomotion velocity, session 7	4.0	4.4	9.7	1.2	-3.1	-2.3	-1.1
Locomotion distance, session 7	4.3	5.5	11.5	1.8	-3.4	-2.7	-0.5
Stereotopy head waving bouts, day 7	1.5	1.7	2.4	-1.4	1.6	1.5	-0.0
Stereotopy head waving duration, day 7	2.6	3.1	5.1	-1.8	2.0	2.3	0.4
Locomotion velocity, session 8	0.4	0.4	1.1	-0.0	-0.3	-0.7	-1.0
Locomotion distance, session 8	1.2	1.7	3.2	0.8	-1.3	-1.8	-1.1
Degree of sensitization distance	6.6	6.6	10.2	2.7	-3.2	-3.0	-0.2
Degree of sensitization stereotypy	1.1	1.2	1.9	-1.4	1.4	0.8	-0.7
Conditioned locomotion	0.4	0.5	1.0	0.7	-1.0	-0.5	-0.4
Cocaine response after cond. corrected	1.2	1.3	2.5	0.0	-1.0	-1.3	-1.6
Cocaine response after cond. not corrected	1.2	1.3	2.2	-0.1	-0.9	-1.4	-1.5
Cocaine response before conditioning	0.2	0.3	0.5	-0.4	0.5	0.4	0.7
Saline control response	0.1	0.1	0.3	-0.0	0.5	0.2	0.3
Bone: connectivity density	2.2	3.4	6.3	1.9	-1.9	-0.0	2.5
Bone: cortical apparent density	0.2	0.3	0.5	-0.4	-0.6	-0.3	-0.7
Bone: cortical area	1.3	2.0	5.1	-1.3	0.9	-0.6	-2.3
Bone: cortical porosity	1.8	2.0	3.0	-1.7	1.7	1.4	-0.4
Bone: cortical porosity	1.6	1.7	3.3	-1.4	1.8	1.2	-0.5
Bone: cortical thickness	1.8	3.0	7.1	-2.0	0.9	-0.3	-2.7
Bone: cortical thickness	4.3	5.0	13.3	-1.2	-0.2	-2.3	-3.6
Bone: cortical tissue density	0.2	0.2	0.4	-0.3	-0.6	-0.3	-0.6
Condit. Reinf. active minus inactive responses	0.6	0.6	1.4	-0.5	0.9	1.2	0.3
Condit. Reinf. active-inactive response ratio	0.3	0.3	0.8	0.2	0.3	0.9	0.6
Condit. Reinf. active responses	0.4	0.5	0.9	-0.6	0.9	0.9	0.1
Condit. Reinf. inactive responses	0.1	0.1	0.2	-0.4	0.3	0.1	0.2
Incentive salience index mean	1.5	1.8	3.0	-1.4	1.7	1.4	-0.2
Condit. Reinf. lever presses	1.5	2.0	3.4	-1.8	1.8	0.9	-0.6
Condit. Reinf. active minus inactive responses	0.1	0.1	0.2	0.3	-0.2	-0.3	-0.4
Condit. Reinf. active-inactive response ratio	0.0	0.0	0.1	0.1	-0.1	0.1	-0.4
Condit. Reinf. active responses	0.2	0.2	0.4	0.5	-0.4	-0.6	-0.3
Condit. Reinf. inactive responses	0.8	1.0	1.4	1.1	-1.0	-1.2	0.2
Condit. Reinf. lever presses	0.5	0.6	1.3	0.0	0.9	0.7	1.1
Condit. Reinf. lever reinforcers received	0.0	0.1	0.1	0.2	-0.1	-0.3	-0.3
Conditioned reinforcement - actives	4.7	4.7	8.9	3.0	-2.1	-2.0	1.0
Conditioned reinforcement - inactives	1.9	2.1	3.2	1.8	-1.3	-0.6	1.7
Conditioned locomotion	1.7	2.1	4.2	1.3	-1.4	-2.0	-0.6
Patch foraging indifference point 0 sec	0.4	0.7	1.0	-0.3	1.0	0.8	1.0
Patch foraging indifference point AUC	1.0	1.1	2.4	0.3	-0.1	-1.4	-1.5
Delay disc. indifference point, 0s delay	0.1	0.1	0.3	-0.2	0.1	-0.3	-0.6
Delay disc. indifference point, 16s delay	2.5	2.6	6.3	-1.8	0.6	-0.5	-2.5
Delay disc. indifference point, 2s delay	0.7	0.8	1.4	-1.0	1.2	0.1	-0.8
Delay disc. indifference point, 24s delay	4.2	4.1	11.3	-1.9	0.6	-1.0	-3.4
Delay disc. indifference point, 4s delay	2.4	2.5	4.4	-2.1	1.4	0.5	-1.9
Delay disc. indifference point, 8s delay	4.2	4.4	7.9	-2.8	1.3	0.5	-2.8
Indifference point function ln k	0.7	1.0	2.0	-0.8	0.9	1.4	0.7
Indifference point function log k	0.7	1.0	2.0	-0.8	0.9	1.4	0.7
Patch foraging total patch changes 0 sec	0.5	0.8	1.5	-0.6	1.2	0.9	0.8
Patch foraging total patch changes 12 sec	0.1	0.2	0.2	-0.4	0.4	-0.5	-0.3
Patch foraging total patch changes 18 sec	0.4	0.5	1.5	0.6	-0.2	-1.2	-0.4
Patch foraging total patch changes 24 sec	0.3	0.3	1.2	-0.3	1.1	0.3	-0.1
Patch foraging total patch changes 6 sec	0.0	0.0	0.0	-0.1	-0.0	-0.1	0.0
Patch foraging time to switch 0 sec	0.2	0.2	0.7	0.2	-0.8	-0.4	0.2
Patch foraging water rate 0 sec	0.4	0.7	1.3	-1.0	1.1	0.6	-0.3
Patch foraging water rate 12 sec	0.4	0.6	1.7	-0.2	1.3	0.8	0.1
Patch foraging water rate 18 sec	2.7	3.6	6.0	-2.5	2.1	1.7	-1.0
Patch foraging water rate 24 sec	0.1	0.1	0.5	-0.0	0.2	-0.1	-0.7
Patch foraging water rate 6 sec	1.2	1.8	4.7	-0.9	2.2	1.3	-0.2
Seeking ratio, delayed vs. immediate footshock	0.1	0.1	0.3	0.1	-0.1	0.3	0.6
Distance traveled before self-admin	0.2	0.2	0.4	0.5	0.7	0.1	0.5
Distance traveled after self-admin	0.1	0.2	0.4	0.2	0.6	-0.3	-0.3
Extensor digitorum longus weight	4.6	18.2	30.7	-5.5	5.1	3.2	-2.3
Bone: elastic displacement	0.2	0.2	0.6	0.4	0.7	0.3	0.2
Bone: elastic work	0.8	1.1	2.8	-0.7	1.7	1.0	-0.1
Bone: endosteal estimation	0.0	0.1	0.1	0.4	0.3	-0.1	0.2
Bone: endosteal perimeter	0.2	0.5	1.1	1.0	0.2	-0.3	0.8
Epididymis fat weight	0.2	0.5	0.7	0.0	-0.8	-0.8	-0.8
Delta time in closed arm before/after self-admin	0.4	0.4	0.9	1.0	-0.4	0.1	0.6
Delta time in open arm before/after self-admin	0.2	0.2	0.7	-0.1	-0.8	-0.2	-0.1
Diff in mean of infusions in LGA sessions	3.3	3.6	6.2	-2.5	1.7	2.2	-0.7
Delay discount exponential model param	4.3	4.5	9.0	2.7	-1.4	0.0	3.0
Extinction: sum of active levers before priming	0.7	0.7	1.6	0.3	-1.2	-1.0	-0.4
Active lever presses in extinction session 6	0.6	0.6	0.9	0.7	-0.9	-0.9	0.1
Bone: final force	0.9	1.4	2.9	-1.4	0.9	0.2	-1.7
Bone: final moment	0.8	1.2	1.7	-1.3	1.2	0.5	-1.2
Food consumed during 24 hour testing period	0.4	0.5	1.1	-0.0	1.0	0.5	0.8
Glucose	0.5	0.8	1.9	-0.3	-0.4	-1.0	-1.4
Heart weight	0.2	0.3	0.9	-0.2	0.3	1.0	0.2
Delay discount hyperbolic model param	4.2	4.5	7.8	2.7	-1.6	-0.2	2.8
Intermittent access intake day 1-15 change	0.3	0.3	0.9	1.0	-0.2	0.1	0.4
Intermittent access intake escalation	0.2	0.2	0.9	0.9	-0.1	-0.1	0.1
Intermittent access intake escalation 2	0.2	0.2	0.4	0.6	0.1	0.4	0.3
Intermitt. access day 1 inactive lever presses	1.3	1.4	2.4	1.1	-1.4	0.3	1.5
Intermitt. access day 15 inactive lever presses	1.4	1.5	3.5	0.2	0.2	1.6	1.9
Intermitt. access escalation Index	0.7	0.7	1.5	0.5	-0.6	-1.2	-0.7
Intermittent access day 1 total infusions	0.6	0.6	1.7	0.5	-0.5	-1.3	-0.5
Intermittent access day 15 total infusions	0.9	1.0	2.0	1.4	-0.8	-1.1	-0.4
Intermittent access terminal intake (last 3 days)	0.7	0.7	1.6	1.3	-0.4	-1.0	-0.5
Intermittent access total infusions	1.8	2.0	3.4	1.4	-1.3	-1.8	-0.9
Intermittent access day 1 locomotion	0.3	0.4	0.6	-0.3	-0.6	-0.7	-0.6
Intermittent access day 15 total locomotion	0.2	0.2	0.3	0.5	-0.5	-0.5	-0.2
Intermittent access total locomotion	0.2	0.2	0.5	-0.1	-0.5	-0.4	-0.7
Intermittent access standard deviation	0.5	0.6	1.4	1.2	0.9	0.2	0.2
Left kidney weight	1.4	3.8	8.0	-1.9	1.8	2.8	0.6
Right kidney weight	1.6	4.6	9.4	-2.3	1.5	3.1	1.3
Cocaine induced anxiety	0.7	0.8	1.5	-0.3	1.2	1.1	0.6
Post-drug Anxiety	1.1	1.2	2.8	-0.2	-0.4	1.4	1.7
Baseline Anxiety	0.4	0.4	1.4	0.1	-1.2	-0.5	0.3
Tail length	0.4	1.3	2.9	1.2	-0.8	-0.3	1.7
Length with tail	0.4	1.6	2.6	-1.1	1.2	1.6	1.0
Length without tail	3.0	6.6	9.1	-3.0	2.9	2.9	-0.4
Times rat made contact with spout	0.2	0.2	0.5	0.4	-0.4	-0.7	-0.3
Lifetime Intake	1.5	1.7	2.7	1.6	-1.1	-1.6	-0.5
Liver weight, left	2.0	3.2	5.0	-2.1	2.2	1.6	-0.7
Liver weight, right	1.0	1.6	2.6	-1.6	1.6	0.6	-1.1
Locomotor activity	3.4	5.4	9.1	-2.1	3.0	2.8	0.4
Locomotor testing distance	1.1	1.8	2.7	-0.2	1.5	1.6	1.4
Locomotor testing rearing	2.5	3.9	9.6	0.7	1.2	2.0	3.1
Locomotion in novel chamber	0.2	0.3	0.9	-0.9	0.1	0.2	-0.5
Locomotion in novel chamber post-restriction	0.4	0.5	1.2	-0.5	0.7	-0.4	-1.1
Fecal boli incidents, locomotor time 1	0.8	0.9	2.2	-0.8	1.5	0.5	-0.7
Change in fecal boli incidents, locomotor task	0.7	0.6	1.5	0.4	-0.7	0.5	1.2
Time >=10cm from walls, locomotor time 1	0.8	0.8	2.0	0.0	-0.0	1.1	1.4
Bouts of movement, locomotor time 1	0.1	0.1	0.2	0.1	0.5	-0.1	-0.4
Total resting periods, locomotor time 1	0.4	0.4	0.9	0.4	0.1	-0.7	-1.0
Rest time, locomotor task time 1	0.6	0.6	1.2	0.0	-0.1	-1.1	-1.1
Distance moved, locomotor task time 1	0.2	0.3	0.8	0.3	-0.3	0.3	0.9
Vertical activity count, locomotor time 1	0.9	1.0	1.6	-0.4	1.2	1.0	1.0
Time >=10cm from walls, locomotor time 2	0.8	0.9	2.2	0.6	0.3	0.9	1.5
Bouts of movement, locomotor time 2	1.6	1.7	4.0	-1.6	0.6	0.2	-2.0
Total resting periods, locomotor time 2	1.9	2.1	4.6	-1.8	0.6	0.1	-2.2
Rest time, locomotor task time 2	1.9	2.2	6.1	-1.3	0.7	-0.8	-2.5
Distance moved, locomotor task time 2	0.6	0.7	1.9	1.0	-0.2	-0.0	1.4
Vertical activity count, locomotor time 2	0.3	0.4	0.8	0.3	0.9	-0.1	0.7
Light reinforcement 1	0.4	0.8	1.7	0.4	-1.3	-1.0	-0.5
Light reinforcement 2	0.9	1.2	2.8	0.8	-1.7	-1.1	-0.4
Bone: marrow area	0.0	0.1	0.2	0.5	0.2	-0.2	0.2
Bone: maximum diameter	0.7	1.4	3.6	-0.7	0.9	-0.8	-1.9
Bone: maximum force	1.3	2.2	4.3	-1.6	1.4	-0.0	-2.1
Bone: maximum moment	1.1	1.9	2.8	-1.5	1.7	0.3	-1.6
Mean time between licks in bursts	2.9	4.1	6.4	2.5	-2.1	-0.1	2.4
Mean num. licks in bursts	0.3	0.4	0.9	1.0	0.3	-0.2	0.7
Cd content in liver	0.4	0.4	0.8	0.7	-0.1	0.5	0.9
Co content in liver	1.0	1.2	3.4	-0.9	0.5	-0.6	-1.8
Cu content in liver	0.2	0.3	0.4	-0.6	0.5	0.7	0.1
Fe content in liver	0.7	0.9	1.4	1.2	-0.9	0.1	1.1
K content in liver	0.7	0.7	1.3	0.5	-1.1	-1.0	-0.4
Mg content in liver	0.7	0.7	1.2	0.9	-1.1	-0.9	0.1
Mn content in liver	1.4	1.6	2.6	1.2	-1.5	-1.6	-0.4
Na content in liver	5.0	5.2	8.9	-2.5	3.0	2.4	0.4
Rb content in liver	0.7	0.9	1.4	1.2	-1.1	-0.4	0.9
Se content in liver	0.3	0.4	0.9	0.1	0.4	0.7	0.9
Sr content in liver	1.4	1.2	2.2	1.5	-0.9	-0.4	1.3
Zn content in liver	2.0	2.2	3.3	-1.2	1.8	1.7	1.1
Bone: minimum diameter	0.6	1.2	2.2	-0.9	1.5	-0.4	-1.3
Time in familiar zone, hab. session 1	0.7	0.6	1.3	0.3	-0.6	-1.1	-0.9
Time in novel zone, hab. session 1	0.9	0.9	1.4	-1.2	1.0	1.1	-0.5
Total zone transitions, hab. session 1	0.6	0.9	1.6	-0.8	1.0	-0.4	-1.3
Total locomotion distance, hab. session 1	0.3	0.4	0.9	-0.3	0.5	-0.7	-1.0
Locomotion velocity, hab. session 1	0.2	0.2	0.4	-0.3	0.6	-0.5	-0.5
Time in familiar zone, hab. session 2	0.2	0.2	0.8	0.3	-0.9	-0.2	-0.0
Time in novel zone, hab. session 2	0.2	0.2	0.5	-0.1	0.7	-0.4	-0.4
Total zone transitions, hab. session 2	0.6	0.7	2.2	-0.7	1.5	0.5	-0.2
Total locomotion distance, hab. session 2	0.2	0.3	0.5	-0.4	0.7	-0.2	-0.6
Locomotion velocity, hab. session 2	0.4	0.5	1.1	-0.7	1.1	-0.0	-0.7
Novel to familiar place preference ratio	0.4	0.4	1.0	0.6	0.2	-1.0	-0.5
Novelty place preference	0.3	0.3	0.7	0.6	0.2	-0.8	-0.3
Time in novel zone, NPP test	0.2	0.2	0.3	0.5	0.3	-0.6	-0.2
Total zone transitions, NPP test	0.0	0.0	0.1	-0.0	0.2	-0.1	-0.2
Total locomotion distance, NPP test	0.7	1.0	1.8	1.3	-1.1	-0.7	0.7
Locomotion velocity, NPP test	0.8	1.1	2.0	1.4	-1.1	-0.9	0.6
Intraocular pressure	1.2	1.7	3.9	2.0	-1.0	-0.3	1.3
Delta distance traveled before/after self-admin	0.2	0.2	0.4	-0.6	0.4	-0.0	-0.6
Delta ambulatory time before/after self-admin	0.3	0.3	0.7	-0.4	0.6	-0.2	-0.8
Parametrial fat weight	2.5	4.8	7.5	2.4	-2.5	-2.7	-0.4
Pavlov. Cond. lever latency	0.6	0.8	1.4	1.0	-1.2	-0.5	0.5
Pavlov. Cond. magazine entry latency	0.5	0.6	1.2	-0.9	0.7	1.1	0.2
Pavlov. Cond. change in total contacts	2.4	2.6	5.4	-1.9	2.3	0.8	-0.9
Pavlov. Cond. index score	1.5	2.0	3.7	-1.9	1.5	1.3	-0.3
Pavlov. Cond. latency score	1.1	1.5	2.6	-1.6	1.4	1.1	-0.2
Pavlov. Cond. lever contacts	1.0	1.1	1.8	-1.3	1.3	1.0	-0.1
Pavlov. Cond. magazine entry number	1.2	1.5	2.2	1.5	-1.4	-1.4	0.0
Pavlov. Cond. intertrial magazine entries	0.1	0.1	0.1	-0.1	0.3	0.3	0.4
Pavlov. Cond. lever-magazine prob. diff.	1.9	2.4	4.5	-2.1	1.7	1.5	-0.4
Pavlov. Cond. response bias	1.7	2.0	3.3	-1.8	1.5	1.5	-0.2
Pavlov. Cond. lever latency	1.8	2.4	3.7	1.1	-1.9	-1.9	-1.1
Pavlov. Cond. magazine entry latency	1.3	1.5	2.5	-1.6	1.2	1.3	-0.5
Pavlov. Cond. change in total contacts	3.4	4.7	7.2	-2.1	2.6	2.7	0.7
Pavlov. Cond. index score	2.4	3.1	4.9	-1.8	2.1	2.2	0.4
Pavlov. Cond. latency score	2.4	3.0	5.1	-1.7	1.9	2.3	0.6
Pavlov. Cond. lever contacts	1.7	2.3	4.2	-0.9	2.1	1.7	1.2
Pavlov. Cond. magazine entry number	0.5	0.7	1.2	1.1	-0.8	-0.6	0.7
Pavlov. Cond. intertrial magazine entries	5.7	7.4	13.6	3.7	-3.0	-2.1	1.6
Pavlov. Cond. lever-magazine prob. diff.	2.2	2.9	4.2	-1.8	2.0	2.0	0.3
Pavlov. Cond. response bias	1.8	2.5	4.9	-1.5	2.2	1.7	0.3
Time in closed arm before self-admin	1.6	1.9	3.9	-2.0	0.9	1.6	0.3
Time in closed arm after self-admin	0.5	0.5	1.0	-0.8	0.5	1.0	0.4
Time in open arm before self-admin	0.6	0.6	1.8	1.4	-0.1	-0.8	0.1
Time in open arm after self-admin	0.5	0.5	1.1	0.8	-1.1	-0.3	0.5
Bone: periosteal estimation	0.2	0.5	1.2	-0.3	0.6	-0.5	-1.1
Bone: periosteal perimeter	0.1	0.2	0.3	-0.0	0.4	-0.5	-0.6
Bone: post-yield work	3.4	4.7	10.7	-0.2	-0.6	-2.8	-3.3
Progressive ratio test 1 active lever presses	1.1	1.1	2.4	0.4	-0.7	-1.5	-1.2
Progressive ratio test 1 breakpoint	1.2	1.3	2.5	0.4	-0.8	-1.6	-1.3
Progressive ratio test 1 inactive lever presses	0.8	0.8	1.5	1.0	-1.2	-0.5	0.8
Progressive ratio test 2 active lever presses	1.4	1.5	3.3	1.8	-1.0	-1.3	0.2
Progressive ratio test 2 breakpoint	0.9	1.0	2.3	1.5	-0.8	-1.0	0.3
Progressive ratio test 2 inactive lever presses	1.2	1.4	2.9	1.7	-0.9	-0.5	1.3
Incentive Sensitization - Responses	1.3	1.3	2.8	1.6	-0.0	0.0	1.7
Incentive Sensitization - Breakpoint	1.5	1.5	3.3	1.6	-0.1	0.1	1.8
Sum of active levers in priming session hrs 5-6	1.4	1.3	2.3	0.9	-1.5	-1.5	-0.2
Progressive ratio	1.0	1.2	1.7	-1.2	1.1	1.3	0.6
Food seeking constrained by brief footshock	0.6	0.8	1.5	0.4	-1.2	-1.0	-0.7
Seeking ratio, punishment vs. effort	0.8	0.9	1.3	0.8	-1.0	-1.1	-0.9
Retroperitoneal fat weight	0.7	2.4	4.9	0.9	-1.4	-2.2	-1.3
Reaction time number correct	0.3	0.5	0.8	0.9	-0.6	-0.1	0.8
Reaction time mean minus median	0.7	1.0	2.0	-1.0	0.9	1.4	0.3
Reaction time mean minus median AUC	0.5	0.7	1.5	-0.7	0.4	1.2	0.8
Reaction time num false alarms	0.4	0.5	1.1	-1.0	0.4	0.8	0.4
Reaction time num false alarms AUC	0.4	0.5	1.1	-1.1	0.6	0.7	0.2
Reaction time trials correct on left	0.3	0.5	0.8	0.9	-0.6	-0.1	0.8
Reaction time trials on left	0.4	0.6	1.0	1.0	-0.7	-0.1	0.9
Reaction time mean	0.7	1.0	2.2	0.2	0.3	1.4	1.5
Reaction time mean AUC	1.2	1.6	3.2	0.0	0.5	1.8	1.7
Median of all reaction times	0.9	1.2	3.0	0.7	-0.0	1.2	1.7
Reaction time omissions	1.7	2.4	4.0	1.8	-1.5	0.1	2.0
Reaction time false alarm rate	0.5	0.7	2.0	-1.4	0.6	0.5	-0.4
Reaction time premature initiation rate	0.4	0.5	1.0	-0.8	0.7	0.3	-1.0
Reaction time premature initiations	0.1	0.1	0.3	-0.2	0.3	0.1	-0.5
Std. dev. reaction times	0.2	0.3	0.9	-0.2	0.3	1.0	0.5
Reaction time trials completed	0.4	0.6	1.0	1.0	-0.7	-0.1	0.9
Reaction time trials AUC	0.5	0.7	1.3	1.2	-0.7	-0.1	1.0
Run reversals in cocaine runway, females	0.8	0.8	1.4	0.9	-1.2	-1.0	0.2
Run reversals in cocaine runway, males	2.8	2.7	5.1	-1.8	2.3	0.7	-1.4
Latency to leave start box in cocaine runway	0.5	0.6	1.1	1.1	0.3	0.2	1.0
Latency to leave start box in cocaine runway, F	0.4	0.5	1.1	0.2	1.0	0.6	0.6
Latency to leave start box in cocaine runway, M	1.6	1.5	3.1	1.4	-0.9	0.3	1.8
Std. dev. time between licks in bursts	1.0	1.2	2.2	1.4	-0.6	0.3	1.5
Total sessions with >9 infusions	1.0	1.1	1.9	1.3	-1.4	-0.3	0.8
Short access day 1 total inactive lever presses	0.3	0.3	0.5	0.7	-0.7	-0.5	-0.1
Short access day 10 total inactive lever presses	0.7	0.8	1.6	0.8	-1.3	-0.6	0.6
Short access day 1 total infusions	1.6	1.8	3.7	1.9	-1.4	-1.0	0.5
Short access day 10 total infusions	1.0	1.1	2.3	0.0	0.4	-1.3	-1.5
Short access total infusions	0.3	0.4	0.7	0.8	-0.4	-0.7	-0.3
Short access day 1 locomotion	0.3	0.3	0.5	0.4	0.3	0.7	0.7
Short access day 10 total locomotion	0.2	0.3	0.7	-0.8	-0.3	0.6	0.0
Short access total locomotion	0.2	0.2	0.4	-0.4	-0.3	0.6	0.4
One hour access (0.3 mA shock)	1.1	1.3	2.6	0.8	-0.5	-1.6	-1.3
Compulsive drug intake	0.7	0.7	1.3	-0.4	-0.5	-1.1	-1.1
One hour access (shock baseline)	0.6	0.7	1.7	1.3	-0.4	-0.8	-0.3
Social response proportion	1.5	1.6	3.2	1.8	-1.5	-0.7	0.7
Social responses	2.0	2.6	5.0	2.2	-1.9	-1.0	0.8
Social time	1.3	1.7	4.8	0.4	0.2	1.4	2.2
Soleus weight	0.3	0.7	1.4	-1.2	0.4	0.0	-1.2
Bone: stiffness	0.5	0.8	1.7	-1.3	0.7	0.1	-1.1
Tibialis anterior weight	4.5	15.5	27.5	-5.2	4.5	3.5	-1.7
Time to tail flick, vehicle, before self-admin	0.6	0.6	1.8	-1.3	0.4	0.6	-0.0
Time to tail flick, vehicle, after self-admin	0.7	0.8	1.5	-1.2	0.7	0.6	-0.9
Time to tail flick, test, before self-admin	0.2	0.2	0.8	-0.3	0.1	0.2	0.9
Time to tail flick, test, after self-admin	4.3	4.5	8.0	2.4	-2.8	-1.3	1.6
Delta time to tail flick, vehicle, before/after SA	0.2	0.2	0.6	0.8	-0.2	-0.2	-0.2
Delta time to tail flick, test, before/after SA	4.0	3.6	6.1	2.4	-2.5	-1.4	0.9
Tibia length	1.4	4.0	7.8	-1.2	1.4	2.8	2.2
Ambulatory time before self-admin	0.1	0.1	0.2	0.2	0.5	-0.3	-0.2
Ambulatory time after self-admin	0.6	0.7	1.6	-0.6	1.3	0.1	-0.9
Bone: tissue strength	0.4	0.4	0.8	0.6	0.2	0.6	0.9
Total heroin consumption	0.7	0.8	1.8	-0.9	1.3	0.4	-0.7
Bone: trabecular number	0.8	1.3	1.9	1.3	-1.4	-0.2	1.2
Bone: trabecular spacing	1.6	2.1	3.6	-1.9	1.4	0.0	-1.8
Bone: trabecular thickness	0.2	0.2	0.5	-0.7	0.2	0.2	-0.6
Bone: trabecular tissue density	1.4	2.0	4.1	-2.0	1.3	1.3	-0.8
Water consumed over 24 hours	0.6	0.8	1.4	-1.1	1.2	0.7	-0.1
Number of responses in last shaping day	0.5	0.5	1.3	-0.5	1.1	0.7	0.1