Hub : Genes

Zfp395

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	pVTA	gene expression	Zfp395	0.05	0.03	1.1e-03	0.01	0.03	0.02	0.01	1.0e-01	1.2e-03	1.9e-02	3.4e-02
2	Adipose	isoform ratio	XM_039093334.2	0.03	0.02	4.5e-03	0.02	0.01	0.02	0.02	1.1e-03	2.3e-02	3.0e-03	4.9e-03
3	Adipose	gene expression	Zfp395	0.09	0.05	1.4e-06	0.05	0.04	0.04	0.05	6.9e-06	1.5e-05	1.2e-05	6.4e-06

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bone: apparent density	0.7	1.2	2.8	-1.7	0.7	0.6
Area under the delay curve	2.9	4.4	9.4	1.9	-3.1	-0.1
BMI with tail	0.1	0.4	0.6	0.8	-0.7	-0.3
BMI without tail	0.0	0.1	0.1	-0.4	0.2	0.4
Body weight	0.4	1.8	3.0	1.5	-0.1	-1.7
Weight adjusted by age	1.2	3.4	6.8	1.4	1.2	-2.6
Bone surface	0.3	0.6	1.4	-1.2	0.6	0.3
Bone volume	0.3	0.5	1.1	-1.1	-0.2	0.7
Breakpoint value in progressive ratio session	0.6	1.1	2.8	0.6	-1.7	0.2
Number of licking bursts	0.1	0.4	1.0	0.1	-1.0	0.4
Context. condit. distance diff. score	2.7	3.3	6.3	-1.4	-1.3	2.5
Locomotion velocity, session 1	0.0	0.1	0.1	-0.1	-0.3	0.2
Locomotion distance, session 1	0.0	0.0	0.0	-0.1	-0.0	0.0
Locomotion velocity, session 2	0.2	0.3	0.7	0.3	-0.8	0.3
Locomotion distance, session 2	0.1	0.1	0.2	-0.4	0.5	-0.0
Locomotion velocity, session 3	0.6	0.7	1.2	0.9	0.3	-1.1
Locomotion distance, session 3	0.1	0.1	0.2	0.4	-0.4	-0.2
Stereotopy head waving bouts, day 3	1.0	1.2	2.1	0.1	1.4	-1.3
Stereotopy head waving duration, day 3	1.1	1.4	2.5	1.1	0.7	-1.6
Locomotion velocity, session 7	3.1	3.4	6.0	-1.7	-1.2	2.4
Locomotion distance, session 7	3.8	4.9	8.2	-2.4	-0.7	2.9
Stereotopy head waving bouts, day 7	1.3	1.6	2.8	1.3	0.4	-1.7
Stereotopy head waving duration, day 7	2.6	3.2	5.9	1.9	0.6	-2.4
Locomotion velocity, session 8	0.5	0.6	1.1	0.2	-1.0	0.8
Locomotion distance, session 8	1.0	1.5	2.8	-1.1	-0.7	1.7
Degree of sensitization distance	5.5	5.9	9.9	-2.7	-0.6	3.2
Degree of sensitization stereotypy	1.0	1.1	2.1	1.5	-0.5	-1.0
Conditioned locomotion	0.6	0.7	1.2	-0.8	-0.6	1.1
Cocaine response after cond. corrected	1.2	1.7	2.7	-0.2	-1.6	1.5
Cocaine response after cond. not corrected	1.0	1.4	2.2	-0.3	-1.4	1.5
Cocaine response before conditioning	0.5	0.6	1.3	-0.2	1.1	-0.7
Saline control response	0.4	0.6	0.9	0.2	0.9	-0.9
Bone: connectivity density	2.5	4.1	6.9	-2.6	2.3	0.1
Bone: cortical apparent density	0.1	0.2	0.5	0.4	-0.7	0.1
Bone: cortical area	1.5	2.4	5.8	1.2	-2.4	0.3
Bone: cortical porosity	1.1	1.1	1.9	1.4	-0.9	-0.9
Bone: cortical porosity	1.2	1.3	2.1	1.5	-0.7	-1.2
Bone: cortical thickness	1.9	3.2	7.2	1.6	-2.7	0.2
Bone: cortical thickness	4.5	5.5	11.7	1.0	-3.4	1.9
Bone: cortical tissue density	0.1	0.2	0.4	0.4	-0.6	0.1
Condit. Reinf. active minus inactive responses	0.3	0.4	0.7	0.6	0.2	-0.8
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.2	0.2	0.4	-0.5
Condit. Reinf. active responses	0.2	0.2	0.5	0.4	0.1	-0.7
Condit. Reinf. inactive responses	0.1	0.1	0.2	-0.2	0.2	-0.4
Incentive salience index mean	0.9	1.1	1.7	1.3	-0.1	-1.3
Condit. Reinf. lever presses	0.7	1.1	1.9	1.4	-0.4	-1.1
Condit. Reinf. active minus inactive responses	0.1	0.2	0.5	-0.4	-0.1	0.7
Condit. Reinf. active-inactive response ratio	0.0	0.1	0.1	-0.0	0.2	0.4
Condit. Reinf. active responses	0.3	0.4	0.7	-0.7	-0.1	0.8
Condit. Reinf. inactive responses	0.7	1.0	1.8	-1.4	-0.1	1.1
Condit. Reinf. lever presses	0.5	0.7	1.2	0.1	1.1	-0.9
Condit. Reinf. lever reinforcers received	0.1	0.2	0.3	-0.4	-0.1	0.6
Conditioned reinforcement - actives	0.9	3.4	4.2	-2.0	1.6	1.9
Conditioned reinforcement - inactives	1.0	2.6	4.2	-1.8	2.1	0.6
Conditioned locomotion	1.1	1.6	4.0	-0.4	-0.8	2.0
Patch foraging indifference point 0 sec	0.3	0.8	1.4	-0.4	1.2	-0.9
Patch foraging indifference point AUC	0.4	0.9	1.4	0.5	-1.1	1.2
Delay disc. indifference point, 0s delay	0.1	0.1	0.2	-0.2	-0.4	0.2
Delay disc. indifference point, 16s delay	2.2	3.1	7.4	1.3	-2.7	0.5
Delay disc. indifference point, 2s delay	0.3	0.4	0.6	0.7	-0.8	-0.2
Delay disc. indifference point, 24s delay	3.2	5.1	12.1	1.4	-3.5	1.1
Delay disc. indifference point, 4s delay	2.6	2.8	4.2	2.1	-1.8	-1.0
Delay disc. indifference point, 8s delay	2.4	4.0	8.1	1.9	-2.8	-0.4
Indifference point function ln k	0.2	0.7	1.6	0.1	0.7	-1.2
Indifference point function log k	0.2	0.7	1.6	0.1	0.7	-1.2
Patch foraging total patch changes 0 sec	0.3	0.8	1.4	0.0	1.0	-1.2
Patch foraging total patch changes 12 sec	0.0	0.0	0.1	0.3	-0.2	-0.1
Patch foraging total patch changes 18 sec	0.1	0.2	0.5	-0.2	-0.2	0.7
Patch foraging total patch changes 24 sec	0.0	0.1	0.2	0.5	0.0	-0.4
Patch foraging total patch changes 6 sec	0.0	0.0	0.0	0.0	-0.0	-0.0
Patch foraging time to switch 0 sec	0.1	0.4	0.7	-0.8	-0.5	0.6
Patch foraging water rate 0 sec	0.2	0.8	1.1	1.1	0.3	-1.1
Patch foraging water rate 12 sec	0.2	0.9	1.6	0.9	0.6	-1.3
Patch foraging water rate 18 sec	1.4	3.2	5.8	2.4	-0.8	-1.8
Patch foraging water rate 24 sec	0.1	0.2	0.4	0.6	-0.4	-0.1
Patch foraging water rate 6 sec	1.1	1.7	2.7	1.6	0.3	-1.5
Seeking ratio, delayed vs. immediate footshock	0.1	0.2	0.4	-0.6	0.4	-0.3
Distance traveled before self-admin	0.2	0.5	0.6	0.5	0.7	-0.8
Distance traveled after self-admin	0.5	0.8	1.4	1.2	-0.9	-0.5
Extensor digitorum longus weight	4.8	19.3	38.1	6.2	-2.8	-3.5
Bone: elastic displacement	0.1	0.1	0.1	-0.2	0.3	-0.2
Bone: elastic work	0.3	0.4	0.8	0.5	-0.4	-0.9
Bone: endosteal estimation	0.0	0.1	0.1	-0.4	0.2	0.1
Bone: endosteal perimeter	0.1	0.3	0.6	-0.8	0.6	0.1
Epididymis fat weight	0.1	0.4	0.9	-0.0	-0.9	0.6
Delta time in closed arm before/after self-admin	0.7	0.7	1.5	-1.2	0.3	0.6
Delta time in open arm before/after self-admin	0.1	0.1	0.3	0.5	-0.2	-0.4
Diff in mean of infusions in LGA sessions	1.5	2.7	5.0	1.6	-0.7	-2.2
Delay discount exponential model param	3.8	5.1	9.9	-2.3	3.2	0.3
Extinction: sum of active levers before priming	0.0	0.0	0.1	-0.3	-0.2	-0.1
Active lever presses in extinction session 6	0.5	0.5	1.1	-0.4	-0.5	1.0
Bone: final force	0.8	1.3	2.8	1.1	-1.7	-0.1
Bone: final moment	0.6	0.9	1.5	1.0	-1.2	-0.4
Food consumed during 24 hour testing period	0.2	0.4	0.6	0.6	0.7	-0.8
Glucose	0.6	0.9	1.5	0.9	-1.2	0.7
Heart weight	0.1	0.2	0.4	-0.6	0.3	-0.1
Delay discount hyperbolic model param	3.3	4.3	8.1	-2.2	2.9	0.3
Intermittent access intake day 1-15 change	0.1	0.8	1.4	-1.2	0.5	0.9
Intermittent access intake escalation	0.1	0.4	0.7	-0.9	0.4	0.5
Intermittent access intake escalation 2	0.0	0.1	0.2	-0.4	0.1	0.0
Intermitt. access day 1 inactive lever presses	0.2	2.0	3.7	-1.5	1.9	0.3
Intermitt. access day 15 inactive lever presses	0.3	1.6	3.0	-0.1	1.7	-1.3
Intermitt. access escalation Index	0.1	0.3	0.5	-0.6	-0.1	0.7
Intermittent access day 1 total infusions	0.2	0.5	1.6	-0.2	0.2	1.2
Intermittent access day 15 total infusions	0.5	1.3	2.2	-1.2	0.4	1.5
Intermittent access terminal intake (last 3 days)	0.5	0.9	2.0	-0.8	0.2	1.4
Intermittent access total infusions	1.7	2.0	4.1	-1.3	0.1	2.0
Intermittent access day 1 locomotion	0.0	0.0	0.1	-0.0	-0.2	0.3
Intermittent access day 15 total locomotion	0.0	0.1	0.3	-0.0	0.1	0.5
Intermittent access total locomotion	0.1	0.1	0.2	-0.2	0.0	0.5
Intermittent access standard deviation	0.0	0.2	0.3	0.6	-0.3	0.3
Left kidney weight	0.3	2.4	5.2	1.2	0.9	-2.3
Right kidney weight	0.7	4.7	10.3	1.0	1.7	-3.2
Cocaine induced anxiety	0.3	0.8	1.5	0.9	-0.3	-1.2
Post-drug Anxiety	1.0	1.2	2.4	-0.2	1.1	-1.5
Baseline Anxiety	0.3	0.4	0.9	-0.9	0.7	0.1
Tail length	0.4	2.0	4.1	-0.8	2.0	-1.0
Length with tail	0.4	1.9	4.1	0.3	1.2	-2.0
Length without tail	0.7	3.6	5.4	2.3	-0.4	-2.3
Times rat made contact with spout	0.1	0.1	0.2	-0.2	-0.3	0.4
Lifetime Intake	1.4	1.7	3.8	-1.2	0.2	1.9
Liver weight, left	1.7	3.0	5.2	1.7	1.0	-2.3
Liver weight, right	1.0	1.7	3.6	1.9	-1.0	-0.7
Locomotor activity	2.6	4.1	8.6	1.9	0.5	-2.9
Locomotor testing distance	0.6	1.6	2.6	-0.4	1.4	-1.6
Locomotor testing rearing	1.3	4.8	9.2	-0.9	3.0	-2.1
Locomotion in novel chamber	0.0	0.0	0.1	-0.1	-0.3	-0.2
Locomotion in novel chamber post-restriction	0.4	1.1	2.1	0.9	-1.4	0.7
Fecal boli incidents, locomotor time 1	0.4	0.9	2.1	1.4	-0.8	-0.2
Change in fecal boli incidents, locomotor task	0.9	1.0	2.3	-0.6	1.5	-0.4
Time >=10cm from walls, locomotor time 1	0.9	1.1	1.6	-0.5	1.2	-1.3
Bouts of movement, locomotor time 1	0.3	0.4	0.9	0.6	-0.9	0.3
Total resting periods, locomotor time 1	0.8	0.9	1.8	0.5	-1.3	0.9
Rest time, locomotor task time 1	0.6	1.0	1.7	0.1	-1.3	1.1
Distance moved, locomotor task time 1	0.2	0.5	1.0	-0.7	1.0	-0.3
Vertical activity count, locomotor time 1	0.2	1.2	1.9	0.5	1.2	-1.4
Time >=10cm from walls, locomotor time 2	0.3	0.8	1.5	-0.1	1.2	-1.0
Bouts of movement, locomotor time 2	0.6	2.0	4.0	1.4	-2.0	-0.3
Total resting periods, locomotor time 2	0.6	2.5	4.5	1.7	-2.1	-0.3
Rest time, locomotor task time 2	2.3	3.9	7.3	2.0	-2.7	0.6
Distance moved, locomotor task time 2	0.9	1.2	2.1	-1.2	1.5	-0.1
Vertical activity count, locomotor time 2	0.2	0.4	0.8	-0.2	0.9	-0.5
Light reinforcement 1	0.0	0.2	0.4	-0.7	-0.3	0.3
Light reinforcement 2	0.2	0.5	0.8	-0.6	-0.6	0.9
Bone: marrow area	0.0	0.1	0.2	-0.4	0.1	0.2
Bone: maximum diameter	1.0	2.0	4.6	1.1	-2.1	0.6
Bone: maximum force	1.3	2.6	5.4	1.5	-2.3	0.0
Bone: maximum moment	1.0	1.9	3.3	1.5	-1.8	-0.3
Mean time between licks in bursts	0.7	4.4	7.2	-2.7	2.4	0.4
Mean num. licks in bursts	0.1	0.2	0.5	-0.2	0.7	0.0
Cd content in liver	1.8	2.1	4.1	0.9	1.1	-2.0
Co content in liver	1.4	1.6	2.7	1.6	-1.4	-0.2
Cu content in liver	0.4	0.5	0.7	0.9	-0.7	-0.4
Fe content in liver	0.9	1.2	2.2	-1.5	1.1	-0.0
K content in liver	0.6	0.6	1.4	-1.2	0.1	0.7
Mg content in liver	1.2	1.3	2.7	-1.6	0.5	1.0
Mn content in liver	1.1	1.2	2.2	-1.5	0.4	1.1
Na content in liver	3.6	4.0	6.6	2.3	-0.2	-2.6
Rb content in liver	1.0	1.1	2.5	-0.8	1.6	-0.4
Se content in liver	1.1	1.3	2.8	-0.8	1.7	-0.8
Sr content in liver	0.7	0.6	0.8	-0.9	0.7	-0.6
Zn content in liver	0.4	0.4	0.9	-0.9	0.6	-0.1
Bone: minimum diameter	0.5	1.0	1.8	1.1	-1.3	-0.0
Time in familiar zone, hab. session 1	0.7	0.7	1.3	-0.4	-0.9	1.1
Time in novel zone, hab. session 1	0.9	1.0	2.0	1.4	-0.4	-1.0
Total zone transitions, hab. session 1	0.5	0.6	1.2	0.8	-1.1	0.3
Total locomotion distance, hab. session 1	0.3	0.4	0.7	0.1	-0.8	0.7
Locomotion velocity, hab. session 1	0.1	0.1	0.1	-0.2	-0.3	0.4
Time in familiar zone, hab. session 2	0.1	0.1	0.2	-0.4	-0.1	0.5
Time in novel zone, hab. session 2	0.1	0.1	0.1	0.3	-0.3	0.1
Total zone transitions, hab. session 2	0.3	0.4	0.9	0.9	-0.1	-0.6
Total locomotion distance, hab. session 2	0.1	0.1	0.2	0.3	-0.5	0.2
Locomotion velocity, hab. session 2	0.2	0.3	0.4	0.6	-0.6	0.1
Novel to familiar place preference ratio	0.2	0.3	0.6	-0.2	-0.4	0.8
Novelty place preference	0.1	0.2	0.4	-0.3	-0.1	0.6
Time in novel zone, NPP test	0.0	0.1	0.1	-0.2	-0.0	0.4
Total zone transitions, NPP test	0.0	0.1	0.1	-0.3	-0.1	0.2
Total locomotion distance, NPP test	1.3	1.9	3.8	-2.0	0.8	1.0
Locomotion velocity, NPP test	1.3	1.9	3.6	-1.9	0.7	1.2
Intraocular pressure	1.3	2.1	3.2	-1.8	1.8	0.3
Delta distance traveled before/after self-admin	0.7	0.8	1.5	1.0	-1.2	-0.3
Delta ambulatory time before/after self-admin	0.6	1.1	2.1	1.0	-1.4	0.1
Parametrial fat weight	1.3	3.1	5.2	-2.3	0.1	2.0
Pavlov. Cond. lever latency	0.5	0.6	1.1	-1.1	0.4	0.7
Pavlov. Cond. magazine entry latency	0.3	0.4	0.9	0.5	0.4	-0.9
Pavlov. Cond. change in total contacts	1.9	2.1	4.4	2.1	-0.9	-1.0
Pavlov. Cond. index score	1.3	1.6	2.5	1.6	-0.3	-1.5
Pavlov. Cond. latency score	0.9	1.1	1.8	1.3	-0.2	-1.3
Pavlov. Cond. lever contacts	0.5	0.6	1.1	1.1	-0.3	-0.8
Pavlov. Cond. magazine entry number	1.2	1.5	2.4	-1.5	0.1	1.5
Pavlov. Cond. intertrial magazine entries	0.1	0.2	0.3	-0.2	0.5	-0.4
Pavlov. Cond. lever-magazine prob. diff.	1.5	1.9	3.1	1.7	-0.3	-1.5
Pavlov. Cond. response bias	1.1	1.3	2.4	1.5	-0.3	-1.2
Pavlov. Cond. lever latency	1.7	2.4	4.2	-1.2	-1.2	2.0
Pavlov. Cond. magazine entry latency	0.6	0.8	1.3	1.1	-0.5	-1.0
Pavlov. Cond. change in total contacts	1.6	4.0	6.7	2.1	0.9	-2.6
Pavlov. Cond. index score	1.6	2.4	4.4	1.6	0.7	-2.1
Pavlov. Cond. latency score	1.6	2.5	4.8	1.4	0.9	-2.2
Pavlov. Cond. lever contacts	1.5	2.2	3.9	1.2	1.2	-2.0
Pavlov. Cond. magazine entry number	0.2	0.3	0.5	-0.7	0.5	0.4
Pavlov. Cond. intertrial magazine entries	3.1	6.7	13.4	-3.7	1.6	2.0
Pavlov. Cond. lever-magazine prob. diff.	1.4	2.2	3.7	1.6	0.4	-1.9
Pavlov. Cond. response bias	1.3	1.8	3.1	1.5	0.5	-1.8
Time in closed arm before self-admin	0.5	0.9	1.6	0.8	0.8	-1.2
Time in closed arm after self-admin	0.1	0.2	0.3	-0.4	0.5	-0.2
Time in open arm before self-admin	0.4	0.5	0.7	-0.9	-0.2	0.8
Time in open arm after self-admin	0.1	0.1	0.2	-0.3	0.4	-0.3
Bone: periosteal estimation	0.3	0.6	1.7	0.4	-1.3	0.4
Bone: periosteal perimeter	0.1	0.2	0.6	0.0	-0.7	0.2
Bone: post-yield work	4.9	8.4	15.9	0.6	-4.0	3.0
Progressive ratio test 1 active lever presses	0.5	0.9	2.6	-0.2	-0.3	1.6
Progressive ratio test 1 breakpoint	0.5	0.8	2.4	-0.1	-0.4	1.5
Progressive ratio test 1 inactive lever presses	0.7	1.7	2.3	-1.5	1.5	0.7
Progressive ratio test 2 active lever presses	0.3	0.4	0.8	-0.3	0.9	0.5
Progressive ratio test 2 breakpoint	0.2	0.3	0.8	-0.1	0.9	0.3
Progressive ratio test 2 inactive lever presses	0.7	2.1	4.2	-1.3	2.1	0.7
Incentive Sensitization - Responses	0.5	1.3	3.0	0.1	1.7	-0.9
Incentive Sensitization - Breakpoint	0.6	1.4	3.2	0.0	1.8	-1.0
Sum of active levers in priming session hrs 5-6	0.3	0.3	0.4	-0.7	-0.3	0.5
Progressive ratio	0.3	0.9	1.5	1.1	0.1	-1.2
Food seeking constrained by brief footshock	0.3	0.4	0.7	-0.2	-0.7	0.8
Seeking ratio, punishment vs. effort	0.3	0.6	1.2	-0.5	-0.7	1.1
Retroperitoneal fat weight	0.3	1.2	1.8	-1.4	-0.1	1.3
Reaction time number correct	0.1	0.3	0.6	-0.6	0.8	0.1
Reaction time mean minus median	0.1	0.7	1.5	0.5	0.7	-1.2
Reaction time mean minus median AUC	0.1	0.7	1.0	0.1	1.0	-1.0
Reaction time num false alarms	0.3	0.5	1.4	0.2	-0.2	-1.2
Reaction time num false alarms AUC	0.3	0.6	1.3	0.6	-0.4	-1.1
Reaction time trials correct on left	0.1	0.3	0.6	-0.6	0.8	0.1
Reaction time trials on left	0.1	0.4	0.8	-0.7	0.9	0.1
Reaction time mean	0.4	0.8	1.6	0.0	1.2	-1.0
Reaction time mean AUC	0.5	1.2	1.9	0.2	1.4	-1.3
Median of all reaction times	0.5	0.7	1.6	-0.1	1.3	-0.8
Reaction time omissions	1.4	2.4	4.0	-2.0	1.7	0.3
Reaction time false alarm rate	0.4	0.6	0.8	0.7	-0.8	-0.9
Reaction time premature initiation rate	0.4	0.6	1.2	1.1	-0.8	-0.3
Reaction time premature initiations	0.1	0.2	0.4	0.7	-0.5	-0.0
Std. dev. reaction times	0.1	0.4	0.6	0.1	0.8	-0.7
Reaction time trials completed	0.1	0.4	0.8	-0.7	0.9	0.1
Reaction time trials AUC	0.1	0.5	1.0	-0.7	1.0	0.1
Run reversals in cocaine runway, females	0.4	0.5	0.8	-0.9	-0.4	0.7
Run reversals in cocaine runway, males	3.1	3.4	7.6	2.8	-1.2	-1.0
Latency to leave start box in cocaine runway	0.4	0.5	1.2	-0.2	1.1	0.6
Latency to leave start box in cocaine runway, F	0.3	0.3	0.6	0.8	0.6	-0.1
Latency to leave start box in cocaine runway, M	1.2	1.2	2.2	-1.1	1.5	0.3
Std. dev. time between licks in bursts	1.3	2.4	3.9	-2.0	1.8	0.0
Total sessions with >9 infusions	0.5	0.6	0.7	-0.7	0.8	0.7
Short access day 1 total inactive lever presses	0.2	0.4	0.6	0.7	-0.3	0.7
Short access day 10 total inactive lever presses	0.0	0.2	0.3	-0.6	0.3	0.6
Short access day 1 total infusions	0.7	1.3	3.3	-0.8	0.2	1.8
Short access day 10 total infusions	0.1	0.2	0.3	0.5	-0.2	0.6
Short access total infusions	0.3	0.4	1.1	-0.1	-0.0	1.1
Short access day 1 locomotion	0.1	0.1	0.2	0.4	0.4	-0.2
Short access day 10 total locomotion	0.0	0.2	0.3	-0.0	0.4	-0.6
Short access total locomotion	0.1	0.2	0.3	0.4	0.4	-0.6
One hour access (0.3 mA shock)	1.4	1.6	4.0	-0.6	-0.7	2.0
Compulsive drug intake	0.4	0.6	1.2	-1.1	-0.3	0.8
One hour access (shock baseline)	0.2	0.6	1.6	-0.4	0.0	1.3
Social response proportion	1.0	1.2	1.7	-1.3	1.0	0.9
Social responses	2.3	3.0	5.7	-2.4	1.2	1.4
Social time	1.7	2.7	5.8	-0.7	2.4	-1.3
Soleus weight	0.4	1.3	2.4	1.2	-1.5	0.2
Bone: stiffness	0.6	1.1	1.7	1.3	-1.2	-0.5
Tibialis anterior weight	4.1	14.1	26.9	5.2	-2.0	-3.4
Time to tail flick, vehicle, before self-admin	0.1	0.2	0.2	0.4	-0.4	-0.4
Time to tail flick, vehicle, after self-admin	0.5	1.0	1.4	1.2	-0.8	-0.9
Time to tail flick, test, before self-admin	0.4	0.5	0.9	-1.0	0.7	0.1
Time to tail flick, test, after self-admin	3.8	4.1	7.0	-2.7	1.7	1.5
Delta time to tail flick, vehicle, before/after SA	0.0	0.0	0.0	-0.1	0.2	0.0
Delta time to tail flick, test, before/after SA	1.5	1.8	2.8	-1.7	1.2	1.1
Tibia length	1.9	5.4	8.7	0.0	2.7	-2.9
Ambulatory time before self-admin	0.1	0.2	0.3	0.5	0.3	-0.3
Ambulatory time after self-admin	1.2	2.0	3.7	1.9	-1.2	-0.9
Bone: tissue strength	0.1	0.1	0.2	-0.3	0.5	-0.1
Total heroin consumption	1.3	1.5	3.0	1.7	-1.0	-0.7
Bone: trabecular number	1.0	1.9	4.0	-2.0	1.3	0.4
Bone: trabecular spacing	1.7	2.5	4.3	2.1	-1.8	-0.3
Bone: trabecular thickness	0.1	0.1	0.3	0.0	-0.6	-0.0
Bone: trabecular tissue density	1.4	2.4	4.3	2.1	-0.7	-1.5
Water consumed over 24 hours	0.4	0.8	1.4	1.2	-0.2	-0.9
Number of responses in last shaping day	1.0	1.2	2.4	1.6	-1.1	-0.3