Mark2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	pVTA	intron excision ratio	chr1_204468888_204469124	0.09	0.05	4.9e-03	0.01	0.04	0.01	0.02	1.3e-01	1.1e-02	1.1e-01	6.6e-02
2	pVTA	intron excision ratio	chr1_204468507_204468716	0.09	0.05	3.7e-03	0.01	0.04	0.01	0.01	1.3e-01	9.1e-03	8.1e-02	1.0e-01
3	LHb	isoform ratio	NM_001398633.1	0.18	0.11	8.3e-03	0	0.04	0.05	0.01	3.1e-01	3.8e-02	2.8e-02	1.4e-01

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3
Bone: apparent density	0.8	1.3	2.0	-1.3	1.4	0.4
Area under the delay curve	0.2	0.2	0.2	-0.4	0.5	-0.3
BMI with tail	4.8	15.4	23.9	-4.7	4.9	-0.7
BMI without tail	2.5	5.1	6.8	-2.5	2.6	-1.4
Body weight	4.3	18.0	25.0	-5.0	5.0	-2.0
Weight adjusted by age	2.0	2.2	3.3	-1.8	1.8	-0.6
Bone surface	3.9	6.9	10.4	-3.2	3.2	0.5
Bone volume	2.1	3.5	4.7	-2.1	2.2	1.2
Breakpoint value in progressive ratio session	1.4	1.5	2.4	-1.5	1.4	-0.4
Number of licking bursts	0.1	0.2	0.2	-0.5	0.5	0.0
Context. condit. distance diff. score	0.4	0.5	0.7	0.8	-0.7	0.4
Locomotion velocity, session 1	0.2	0.2	0.5	-0.2	0.2	-0.7
Locomotion distance, session 1	0.7	1.0	1.4	-1.1	1.2	-0.5
Locomotion velocity, session 2	2.6	3.0	4.1	-2.0	2.0	-1.0
Locomotion distance, session 2	0.5	0.8	0.8	-0.8	0.9	-0.9
Locomotion velocity, session 3	0.4	0.5	0.7	-0.6	0.8	0.5
Locomotion distance, session 3	0.0	0.0	0.1	-0.2	0.2	-0.0
Stereotopy head waving bouts, day 3	0.1	0.1	0.2	-0.1	0.3	0.5
Stereotopy head waving duration, day 3	0.2	0.3	0.5	0.4	-0.3	0.7
Locomotion velocity, session 7	0.3	0.3	0.8	0.2	-0.0	0.9
Locomotion distance, session 7	0.0	0.1	0.2	-0.0	0.1	-0.4
Stereotopy head waving bouts, day 7	0.6	0.6	1.8	-0.1	0.2	1.3
Stereotopy head waving duration, day 7	1.1	1.3	1.9	-1.4	1.4	0.5
Locomotion velocity, session 8	0.7	0.8	1.8	-0.6	0.6	-1.3
Locomotion distance, session 8	0.1	0.1	0.2	-0.2	0.3	0.5
Degree of sensitization distance	0.1	0.1	0.2	-0.3	0.4	0.1
Degree of sensitization stereotypy	0.7	0.8	0.9	-0.9	0.9	1.0
Conditioned locomotion	1.0	1.2	1.4	-1.2	1.2	-0.9
Cocaine response after cond. corrected	0.5	0.6	1.0	1.0	-0.9	-0.1
Cocaine response after cond. not corrected	0.3	0.3	0.6	0.8	-0.7	-0.1
Cocaine response before conditioning	0.3	0.4	0.6	-0.8	0.7	0.0
Saline control response	3.2	4.2	4.7	-2.2	2.1	-1.9
Bone: connectivity density	2.6	4.1	6.2	-2.4	2.5	-0.3
Bone: cortical apparent density	0.2	0.2	0.7	-0.0	-0.1	-0.8
Bone: cortical area	0.8	1.2	1.8	-1.3	1.3	0.3
Bone: cortical porosity	0.0	0.0	0.0	0.2	-0.2	-0.0
Bone: cortical porosity	0.1	0.1	0.2	-0.2	0.2	-0.5
Bone: cortical thickness	1.8	2.9	4.3	-1.6	1.4	-2.1
Bone: cortical thickness	0.9	1.1	2.9	-0.4	0.4	-1.7
Bone: cortical tissue density	0.2	0.3	0.9	-0.1	-0.1	-0.9
Condit. Reinf. active minus inactive responses	0.2	0.3	0.3	-0.6	0.5	-0.4
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.2	0.1	-0.2	-0.4
Condit. Reinf. active responses	0.2	0.2	0.3	-0.6	0.6	0.2
Condit. Reinf. inactive responses	0.3	0.4	0.9	-0.3	0.4	1.0
Incentive salience index mean	0.7	0.8	1.1	-1.1	1.1	-0.4
Condit. Reinf. lever presses	0.8	1.0	1.5	-1.2	1.2	0.1
Condit. Reinf. active minus inactive responses	0.6	0.7	1.7	0.5	-0.4	1.3
Condit. Reinf. active-inactive response ratio	1.8	1.9	5.1	0.5	-0.4	2.3
Condit. Reinf. active responses	0.1	0.1	0.2	-0.1	0.0	0.5
Condit. Reinf. inactive responses	0.5	0.6	1.7	-0.4	0.3	-1.3
Condit. Reinf. lever presses	1.4	1.9	2.8	-1.7	1.6	0.5
Condit. Reinf. lever reinforcers received	0.1	0.1	0.2	-0.4	0.3	0.4
Conditioned reinforcement - actives	1.3	1.3	2.6	0.9	-0.8	1.6
Conditioned reinforcement - inactives	4.2	4.7	7.6	1.9	-1.8	2.8
Conditioned locomotion	6.0	7.3	7.9	2.8	-2.7	2.6
Patch foraging indifference point 0 sec	0.0	0.0	0.1	-0.1	0.1	0.3
Patch foraging indifference point AUC	2.3	2.6	4.1	-2.0	1.9	-0.4
Delay disc. indifference point, 0s delay	0.1	0.1	0.2	-0.2	0.3	-0.5
Delay disc. indifference point, 16s delay	0.4	0.4	1.0	0.3	-0.2	1.0
Delay disc. indifference point, 2s delay	0.1	0.1	0.1	-0.2	0.4	0.2
Delay disc. indifference point, 24s delay	0.3	0.3	1.0	-0.0	0.0	-1.0
Delay disc. indifference point, 4s delay	0.5	0.5	1.1	-0.4	0.5	-1.1
Delay disc. indifference point, 8s delay	0.1	0.1	0.4	0.0	0.0	-0.6
Indifference point function ln k	4.1	5.8	9.0	3.0	-2.8	0.6
Indifference point function log k	4.1	5.8	9.0	3.0	-2.8	0.6
Patch foraging total patch changes 0 sec	0.0	0.0	0.0	-0.0	-0.0	-0.2
Patch foraging total patch changes 12 sec	3.9	5.0	7.3	-2.7	2.6	-1.1
Patch foraging total patch changes 18 sec	0.4	0.5	0.8	-0.9	0.8	0.0
Patch foraging total patch changes 24 sec	3.5	4.2	6.1	-2.5	2.4	-1.0
Patch foraging total patch changes 6 sec	1.0	1.5	2.0	-1.4	1.4	-0.8
Patch foraging time to switch 0 sec	1.7	2.7	4.2	-1.9	2.0	0.2
Patch foraging water rate 0 sec	2.6	4.2	6.2	2.4	-2.5	0.7
Patch foraging water rate 12 sec	4.9	7.4	11.2	3.3	-3.3	0.2
Patch foraging water rate 18 sec	1.5	2.0	3.0	1.7	-1.7	-0.1
Patch foraging water rate 24 sec	2.1	2.9	4.4	2.1	-2.1	0.2
Patch foraging water rate 6 sec	2.4	3.5	5.2	2.3	-2.3	-0.3
Seeking ratio, delayed vs. immediate footshock	0.1	0.1	0.1	0.2	-0.2	-0.3
Distance traveled before self-admin	0.8	0.9	1.2	-1.1	1.0	0.6
Distance traveled after self-admin	0.1	0.1	0.1	-0.3	0.2	0.3
Extensor digitorum longus weight	6.7	26.2	35.8	-6.0	5.8	-3.0
Bone: elastic displacement	1.6	1.8	2.4	1.5	-1.5	-0.9
Bone: elastic work	1.2	1.5	3.8	-0.7	0.6	-1.9
Bone: endosteal estimation	0.7	1.6	4.7	-0.1	0.4	2.2
Bone: endosteal perimeter	1.5	3.2	9.5	0.2	0.1	3.1
Epididymis fat weight	0.9	2.2	4.6	1.1	-0.9	2.1
Delta time in closed arm before/after self-admin	0.9	0.9	2.5	-0.3	0.3	-1.6
Delta time in open arm before/after self-admin	0.4	0.4	0.6	-0.6	0.5	0.8
Diff in mean of infusions in LGA sessions	0.1	0.1	0.2	-0.4	0.2	-0.4
Delay discount exponential model param	0.2	0.2	0.2	0.4	-0.5	0.4
Extinction: sum of active levers before priming	3.5	3.4	5.0	-2.2	2.1	-0.9
Active lever presses in extinction session 6	1.2	1.2	1.9	-1.4	1.3	0.0
Bone: final force	2.9	4.7	7.0	-2.6	2.6	-0.5
Bone: final moment	2.7	4.3	6.4	-2.5	2.5	-0.4
Food consumed during 24 hour testing period	0.0	0.0	0.1	-0.0	-0.0	0.3
Glucose	1.1	1.6	2.7	1.1	-0.9	1.6
Heart weight	1.3	1.8	2.7	1.7	-1.5	0.7
Delay discount hyperbolic model param	0.2	0.2	0.3	0.5	-0.6	0.4
Intermittent access intake day 1-15 change	1.2	1.2	1.7	1.0	-1.0	1.3
Intermittent access intake escalation	1.0	1.0	1.6	0.8	-0.9	1.3
Intermittent access intake escalation 2	0.5	0.5	1.1	0.4	-0.4	1.0
Intermitt. access day 1 inactive lever presses	2.1	2.2	2.3	1.5	-1.4	1.5
Intermitt. access day 15 inactive lever presses	2.2	2.4	5.7	0.9	-0.8	2.4
Intermitt. access escalation Index	0.7	0.6	1.0	1.0	-0.9	0.1
Intermittent access day 1 total infusions	2.8	3.2	7.6	1.2	-0.8	2.8
Intermittent access day 15 total infusions	6.3	7.1	12.7	2.2	-2.0	3.6
Intermittent access terminal intake (last 3 days)	4.4	4.8	12.3	1.1	-0.9	3.5
Intermittent access total infusions	3.7	4.1	9.8	1.2	-1.0	3.1
Intermittent access day 1 locomotion	1.0	1.0	2.7	0.5	-0.2	1.7
Intermittent access day 15 total locomotion	3.0	3.2	7.3	1.1	-1.0	2.7
Intermittent access total locomotion	3.8	4.3	11.9	0.8	-0.5	3.4
Intermittent access standard deviation	1.7	1.8	2.1	1.3	-1.3	1.4
Left kidney weight	0.3	0.7	1.8	0.5	-0.4	1.3
Right kidney weight	0.3	0.9	2.5	-0.2	0.2	1.6
Cocaine induced anxiety	0.2	0.3	0.5	-0.4	0.4	0.7
Post-drug Anxiety	0.6	0.7	1.0	-1.0	1.0	0.4
Baseline Anxiety	1.3	1.3	1.5	-1.2	1.1	-1.2
Tail length	0.7	2.1	4.6	-1.0	0.8	-2.1
Length with tail	1.6	5.9	7.3	-2.7	2.5	-2.0
Length without tail	1.5	3.4	5.0	-2.2	2.2	-0.7
Times rat made contact with spout	0.5	0.5	1.4	-0.3	0.2	-1.2
Lifetime Intake	2.8	3.1	6.8	1.2	-1.0	2.6
Liver weight, left	0.1	0.1	0.1	0.3	-0.2	0.4
Liver weight, right	0.2	0.3	0.5	-0.6	0.7	-0.4
Locomotor activity	1.5	2.4	3.5	1.9	-1.9	-0.4
Locomotor testing distance	1.7	2.8	3.9	2.0	-2.0	-0.9
Locomotor testing rearing	1.3	2.0	2.9	1.7	-1.7	-0.4
Locomotion in novel chamber	3.6	4.4	8.2	1.7	-1.5	2.9
Locomotion in novel chamber post-restriction	2.8	3.4	4.0	2.0	-1.9	1.6
Fecal boli incidents, locomotor time 1	0.5	0.6	1.5	-0.3	0.3	1.2
Change in fecal boli incidents, locomotor task	0.6	0.6	1.6	0.2	-0.1	-1.3
Time >=10cm from walls, locomotor time 1	1.5	1.6	4.6	0.3	-0.1	2.1
Bouts of movement, locomotor time 1	0.2	0.2	0.4	0.0	-0.3	-0.7
Total resting periods, locomotor time 1	0.0	0.0	0.1	-0.0	-0.2	-0.3
Rest time, locomotor task time 1	1.6	1.8	2.5	1.6	-1.6	0.5
Distance moved, locomotor task time 1	0.5	0.5	0.8	-0.9	0.9	-0.0
Vertical activity count, locomotor time 1	0.7	0.7	0.8	0.9	-0.8	0.8
Time >=10cm from walls, locomotor time 2	0.3	0.3	0.8	0.2	-0.2	0.9
Bouts of movement, locomotor time 2	0.2	0.3	0.3	-0.6	0.5	-0.5
Total resting periods, locomotor time 2	0.1	0.1	0.1	-0.4	0.3	-0.2
Rest time, locomotor task time 2	2.0	2.3	3.1	1.7	-1.6	1.1
Distance moved, locomotor task time 2	0.5	0.6	0.7	-0.8	0.7	-0.8
Vertical activity count, locomotor time 2	0.6	0.7	1.3	0.6	-0.7	-1.1
Light reinforcement 1	0.2	0.3	0.5	0.6	-0.7	-0.0
Light reinforcement 2	1.9	2.5	6.8	0.7	-0.6	2.6
Bone: marrow area	0.7	1.5	4.4	0.0	0.3	2.1
Bone: maximum diameter	0.8	1.5	2.0	-1.1	1.2	1.4
Bone: maximum force	4.3	7.4	11.3	-3.3	3.4	0.3
Bone: maximum moment	3.8	6.5	10.0	-3.1	3.2	0.2
Mean time between licks in bursts	1.2	1.7	4.3	-0.6	0.5	-2.1
Mean num. licks in bursts	0.3	0.4	0.5	0.6	-0.7	-0.5
Cd content in liver	1.2	1.3	1.9	1.0	-1.0	1.4
Co content in liver	3.1	3.6	4.9	2.1	-2.2	-1.2
Cu content in liver	0.1	0.1	0.2	-0.3	0.2	-0.5
Fe content in liver	0.2	0.2	0.2	-0.4	0.4	0.4
K content in liver	2.5	2.4	3.6	-1.8	1.9	-0.6
Mg content in liver	0.6	0.6	1.1	-0.9	1.0	0.2
Mn content in liver	1.6	1.8	2.8	-1.7	1.6	0.1
Na content in liver	0.8	0.9	1.3	-1.1	1.1	-0.0
Rb content in liver	0.9	1.1	1.4	1.2	-1.1	0.8
Se content in liver	0.9	1.1	2.9	-0.4	0.4	1.7
Sr content in liver	2.1	2.0	2.8	-1.7	1.5	-0.9
Zn content in liver	1.5	1.7	2.5	-1.6	1.5	-0.4
Bone: minimum diameter	0.7	1.3	3.6	-0.2	0.4	1.9
Time in familiar zone, hab. session 1	0.0	0.0	0.1	0.0	0.0	0.3
Time in novel zone, hab. session 1	0.5	0.5	0.5	0.7	-0.7	-0.6
Total zone transitions, hab. session 1	0.2	0.3	0.5	-0.7	0.6	-0.3
Total locomotion distance, hab. session 1	0.1	0.2	0.5	0.1	-0.0	0.7
Locomotion velocity, hab. session 1	0.1	0.1	0.1	-0.2	0.3	0.4
Time in familiar zone, hab. session 2	0.7	0.8	2.0	0.4	-0.4	-1.4
Time in novel zone, hab. session 2	0.4	0.4	0.4	-0.6	0.7	0.7
Total zone transitions, hab. session 2	1.5	2.0	2.8	-1.6	1.7	-0.6
Total locomotion distance, hab. session 2	0.2	0.3	0.5	-0.6	0.7	-0.1
Locomotion velocity, hab. session 2	0.1	0.2	0.3	-0.4	0.5	0.4
Novel to familiar place preference ratio	1.5	1.6	2.1	-1.5	1.4	0.8
Novelty place preference	1.0	1.0	1.1	-1.1	1.0	0.9
Time in novel zone, NPP test	0.9	0.9	1.1	-1.1	1.0	0.7
Total zone transitions, NPP test	1.6	2.3	3.2	-1.8	1.8	-0.7
Total locomotion distance, NPP test	0.1	0.1	0.3	-0.4	0.5	-0.0
Locomotion velocity, NPP test	0.0	0.1	0.1	-0.3	0.3	0.0
Intraocular pressure	1.2	1.6	1.7	1.2	-1.3	1.3
Delta distance traveled before/after self-admin	0.3	0.3	0.4	0.6	-0.6	-0.6
Delta ambulatory time before/after self-admin	0.4	0.5	0.8	0.6	-0.6	-0.9
Parametrial fat weight	0.8	1.6	3.7	0.9	-0.6	1.9
Pavlov. Cond. lever latency	0.9	1.1	1.7	1.3	-1.3	0.1
Pavlov. Cond. magazine entry latency	0.9	1.1	1.7	-1.3	1.3	0.2
Pavlov. Cond. change in total contacts	0.5	0.6	1.1	-0.6	0.6	1.0
Pavlov. Cond. index score	0.3	0.4	0.6	-0.8	0.8	0.1
Pavlov. Cond. latency score	0.3	0.4	0.6	-0.8	0.8	0.0
Pavlov. Cond. lever contacts	0.3	0.3	0.5	-0.7	0.7	-0.2
Pavlov. Cond. magazine entry number	0.2	0.3	0.4	0.6	-0.6	-0.3
Pavlov. Cond. intertrial magazine entries	0.8	1.0	1.3	1.1	-1.1	0.7
Pavlov. Cond. lever-magazine prob. diff.	0.6	0.7	1.1	-1.0	1.0	0.0
Pavlov. Cond. response bias	0.3	0.3	0.5	-0.7	0.7	0.2
Pavlov. Cond. lever latency	0.8	1.1	1.4	1.2	-1.2	-0.7
Pavlov. Cond. magazine entry latency	2.8	3.2	4.8	-2.2	2.1	-0.8
Pavlov. Cond. change in total contacts	1.5	2.1	2.6	-1.6	1.5	1.1
Pavlov. Cond. index score	2.1	2.8	4.2	-2.1	2.0	0.3
Pavlov. Cond. latency score	2.0	2.5	3.8	-1.9	1.9	0.4
Pavlov. Cond. lever contacts	0.4	0.5	0.6	-0.8	0.8	0.5
Pavlov. Cond. magazine entry number	4.6	5.6	8.6	2.9	-2.8	0.6
Pavlov. Cond. intertrial magazine entries	1.0	1.3	1.8	1.3	-1.3	0.6
Pavlov. Cond. lever-magazine prob. diff.	2.4	3.1	4.8	-2.2	2.1	0.1
Pavlov. Cond. response bias	1.2	1.7	2.7	-1.6	1.5	0.2
Time in closed arm before self-admin	0.3	0.4	0.8	-0.4	0.4	0.9
Time in closed arm after self-admin	0.1	0.1	0.2	0.4	-0.3	-0.4
Time in open arm before self-admin	1.5	1.6	2.6	1.1	-1.1	-1.6
Time in open arm after self-admin	0.3	0.3	0.4	0.5	-0.6	-0.5
Bone: periosteal estimation	0.8	1.7	2.9	-1.0	1.2	1.7
Bone: periosteal perimeter	0.7	1.2	1.6	-0.9	1.0	1.3
Bone: post-yield work	2.9	4.0	7.0	-1.5	1.7	2.6
Progressive ratio test 1 active lever presses	3.0	3.1	3.3	1.8	-1.7	1.8
Progressive ratio test 1 breakpoint	2.7	2.8	3.0	1.7	-1.7	1.6
Progressive ratio test 1 inactive lever presses	0.3	0.3	0.4	0.6	-0.6	0.5
Progressive ratio test 2 active lever presses	4.1	4.5	7.7	1.8	-1.6	2.8
Progressive ratio test 2 breakpoint	5.3	6.0	7.6	2.3	-2.2	2.8
Progressive ratio test 2 inactive lever presses	5.5	6.3	11.3	2.0	-1.9	3.4
Incentive Sensitization - Responses	0.8	0.8	2.3	0.2	-0.1	1.5
Incentive Sensitization - Breakpoint	1.0	1.0	2.8	0.3	-0.3	1.7
Sum of active levers in priming session hrs 5-6	0.5	0.5	0.8	-0.7	0.5	0.9
Progressive ratio	1.9	2.2	3.3	-1.8	1.8	-0.2
Food seeking constrained by brief footshock	0.4	0.5	1.5	-0.2	0.2	-1.2
Seeking ratio, punishment vs. effort	1.6	2.0	2.8	1.6	-1.7	-0.8
Retroperitoneal fat weight	2.9	9.6	10.9	3.1	-2.8	3.3
Reaction time number correct	0.2	0.3	0.5	-0.5	0.4	-0.7
Reaction time mean minus median	1.3	1.7	2.7	-1.6	1.6	0.3
Reaction time mean minus median AUC	0.4	0.6	0.9	-1.0	0.9	-0.1
Reaction time num false alarms	1.1	1.4	1.6	1.1	-1.2	-1.3
Reaction time num false alarms AUC	0.8	1.1	2.8	0.5	-0.6	-1.7
Reaction time trials correct on left	0.2	0.3	0.5	-0.5	0.4	-0.7
Reaction time trials on left	0.2	0.3	0.6	-0.5	0.4	-0.8
Reaction time mean	0.2	0.3	1.0	0.0	-0.0	1.0
Reaction time mean AUC	0.3	0.4	1.2	0.1	-0.1	1.1
Median of all reaction times	0.3	0.4	1.2	0.2	-0.2	1.1
Reaction time omissions	0.1	0.1	0.1	-0.4	0.3	-0.4
Reaction time false alarm rate	0.6	0.8	1.0	0.8	-0.8	-1.0
Reaction time premature initiation rate	3.7	4.9	6.7	-2.0	2.0	-2.6
Reaction time premature initiations	4.4	6.1	8.9	-2.3	2.1	-3.0
Std. dev. reaction times	0.1	0.1	0.3	-0.3	0.2	0.5
Reaction time trials completed	0.2	0.3	0.6	-0.5	0.4	-0.8
Reaction time trials AUC	0.2	0.3	0.5	-0.4	0.3	-0.7
Run reversals in cocaine runway, females	1.6	1.5	1.7	-1.2	1.3	-1.3
Run reversals in cocaine runway, males	0.2	0.2	0.2	0.5	-0.5	-0.3
Latency to leave start box in cocaine runway	0.2	0.2	0.5	0.0	0.1	0.7
Latency to leave start box in cocaine runway, F	0.0	0.0	0.1	-0.1	0.1	0.4
Latency to leave start box in cocaine runway, M	0.2	0.2	0.3	0.5	-0.3	0.5
Std. dev. time between licks in bursts	0.6	0.8	1.9	0.4	-0.4	-1.4
Total sessions with >9 infusions	0.9	0.9	1.5	0.9	-0.7	1.2
Short access day 1 total inactive lever presses	2.3	2.6	3.1	1.7	-1.6	1.5
Short access day 10 total inactive lever presses	2.6	2.9	4.5	2.1	-2.0	0.2
Short access day 1 total infusions	1.6	1.7	2.4	1.2	-1.0	1.5
Short access day 10 total infusions	1.0	1.2	3.2	0.4	-0.2	1.8
Short access total infusions	0.7	0.8	1.7	0.6	-0.5	1.3
Short access day 1 locomotion	0.5	0.6	1.7	0.3	-0.1	1.3
Short access day 10 total locomotion	0.4	0.5	1.3	0.3	-0.1	1.2
Short access total locomotion	0.3	0.4	1.1	0.0	0.2	1.0
One hour access (0.3 mA shock)	6.8	8.0	10.2	2.7	-2.5	3.2
Compulsive drug intake	3.5	3.5	9.1	-0.9	0.7	-3.0
One hour access (shock baseline)	9.0	10.5	18.2	2.7	-2.5	4.3
Social response proportion	0.4	0.5	0.7	-0.9	0.8	-0.1
Social responses	0.2	0.3	0.8	-0.3	0.2	-0.9
Social time	0.3	0.3	0.9	-0.3	0.2	-0.9
Soleus weight	2.7	8.0	11.0	3.3	-3.2	1.8
Bone: stiffness	2.3	3.6	5.5	-2.3	2.3	0.5
Tibialis anterior weight	8.3	28.3	38.8	-6.2	6.0	-3.2
Time to tail flick, vehicle, before self-admin	1.6	1.7	2.6	-1.5	1.6	0.3
Time to tail flick, vehicle, after self-admin	3.4	3.6	4.3	-2.0	2.1	-1.6
Time to tail flick, test, before self-admin	0.1	0.1	0.2	-0.3	0.5	0.2
Time to tail flick, test, after self-admin	0.0	0.0	0.1	-0.1	0.1	-0.2
Delta time to tail flick, vehicle, before/after SA	0.8	0.8	1.5	-0.7	0.7	-1.2
Delta time to tail flick, test, before/after SA	0.1	0.1	0.3	-0.0	-0.2	-0.5
Tibia length	1.1	3.2	4.1	-2.0	2.0	1.2
Ambulatory time before self-admin	0.9	0.9	1.2	-0.9	0.9	1.1
Ambulatory time after self-admin	0.4	0.5	1.4	-0.0	0.0	1.2
Bone: tissue strength	0.2	0.2	0.3	0.2	-0.3	0.6
Total heroin consumption	2.9	3.4	4.4	-2.1	1.9	-1.5
Bone: trabecular number	1.2	1.8	2.5	-1.5	1.6	0.9
Bone: trabecular spacing	1.0	1.2	1.4	1.1	-1.2	-1.0
Bone: trabecular thickness	0.5	0.6	1.4	0.5	-0.4	1.2
Bone: trabecular tissue density	4.2	5.9	7.8	2.8	-2.8	1.4
Water consumed over 24 hours	0.5	0.6	1.4	-0.6	0.5	-1.2
Number of responses in last shaping day	0.5	0.5	0.8	0.9	-0.9	0.0