Hub : Genes

Scn8a

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 NAcc intron excision ratio chr7_132125810_132126074 0.02 0.02 6.6e-03 0 0.01 0.01 0 2.7e-01 2.2e-02 3.1e-02 1.3e-01
2 BLA mRNA stability Scn8a 0.05 0.04 3.6e-03 0.01 0.02 0 0 1.3e-01 4.0e-02 2.2e-01 1.8e-01
3 NAcc alternative TSS XM_039078609.1 0.02 0.01 8.4e-03 0.01 0.01 0.01 0.01 1.9e-02 1.2e-02 2.7e-02 2.7e-02
4 Brain mRNA stability Scn8a 0.02 0.02 5.7e-03 0.01 0.02 0.01 0.01 2.7e-02 6.5e-03 2.4e-02 3.3e-02
5 NAcc alternative polyA XM_039078606.1 0.03 0.02 2.3e-04 0.02 0.03 0.03 0.02 8.4e-04 2.2e-04 4.9e-04 7.4e-04
6 NAcc alternative polyA XM_039078606.1 0.03 0.02 1.2e-04 0.03 0.03 0.03 0.03 1.8e-04 1.6e-04 4.7e-04 4.1e-04
7 PL mRNA stability Scn8a 0.03 0.02 2.3e-03 0.03 0.02 0.02 0.03 4.0e-04 3.2e-03 5.1e-03 7.9e-04
8 Adipose isoform ratio XM_039078607.1 0.03 0.02 5.2e-03 0.01 0 0 0 3.7e-02 3.1e-01 1.0e-01 2.5e-01
9 Adipose alternative polyA NM_019266.3 0.26 0.1 0.0e+00 0.28 0.26 0.26 0.26 7.6e-31 7.8e-29 2.5e-28 3.5e-29
10 Adipose alternative polyA XM_039078606.1 0.25 0.09 0.0e+00 0.27 0.25 0.25 0.25 1.9e-29 1.8e-27 9.4e-28 7.8e-28
11 Adipose alternative polyA NM_019266.3 0.26 0.1 0.0e+00 0.27 0.26 0.26 0.26 4.8e-30 3.5e-28 2.4e-28 2.3e-28
12 Adipose alternative polyA XM_039078606.1 0.26 0.1 0.0e+00 0.27 0.25 0.26 0.26 8.0e-30 6.3e-28 4.1e-28 3.8e-28
13 Adipose isoform ratio NM_019266.3 0.26 0.1 0.0e+00 0.24 0.23 0.22 0.23 1.8e-26 8.4e-25 4.7e-24 1.2e-25
14 Adipose gene expression Scn8a 0.66 0.09 0.0e+00 0.61 0.6 0.6 0.6 1.0e-85 5.4e-84 3.4e-83 8.2e-84
15 Liver alternative TSS NM_019266.3 0.1 0.09 8.9e-03 0 0.01 0 0 7.4e-02 4.3e-02 1.8e-01 8.0e-02
16 Adipose isoform ratio XM_039078609.1 0.06 0.04 2.8e-06 0.04 0.05 0.04 0.04 1.3e-05 7.1e-06 1.7e-05 1.9e-05

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16
Bone: apparent density0.61.03.9-2.01.7-1.21.1-0.6-0.6-0.8-0.6-0.60.6-0.60.6-0.6-0.5-1.8-0.2
Area under the delay curve0.20.20.5-0.60.7-0.50.5-0.4-0.4-0.7-0.3-0.30.3-0.30.3-0.3-0.2-0.5-0.1
BMI with tail2.16.914.9-3.93.8-3.43.2-2.8-2.7-1.9-2.2-2.22.2-2.22.2-2.2-2.50.3-2.2
BMI without tail0.30.71.5-1.20.9-0.80.7-0.5-0.50.1-1.0-1.01.0-1.01.0-1.0-1.00.2-0.8
Body weight1.04.211.8-3.43.4-2.82.4-1.9-1.9-1.3-1.6-1.61.6-1.61.6-1.6-1.5-1.4-1.1
Weight adjusted by age1.31.42.2-1.01.2-1.21.3-1.3-1.3-1.5-1.2-1.21.2-1.21.2-1.2-1.00.7-1.1
Bone surface0.81.45.7-2.42.2-1.51.3-0.8-0.8-0.3-0.6-0.60.6-0.60.6-0.6-0.5-2.1-0.2
Bone volume1.01.86.0-2.42.2-1.71.4-1.0-1.0-0.9-1.0-1.01.0-1.01.0-1.0-0.9-1.7-0.6
Breakpoint value in progressive ratio session0.30.41.10.2-0.30.4-0.50.50.51.00.70.7-0.70.7-0.70.70.4-0.70.6
Number of licking bursts0.10.10.60.5-0.30.2-0.1-0.1-0.10.2-0.2-0.20.2-0.20.2-0.20.20.8-0.3
Context. condit. distance diff. score0.10.10.3-0.10.00.1-0.20.30.30.10.40.4-0.40.4-0.40.40.2-0.50.4
Locomotion velocity, session 11.71.83.92.0-1.81.6-1.51.31.30.71.31.3-1.31.3-1.31.31.30.21.3
Locomotion distance, session 10.40.51.61.3-1.20.8-0.70.50.50.20.40.4-0.40.4-0.40.40.41.20.2
Locomotion velocity, session 20.70.81.11.0-0.90.9-0.90.80.80.60.90.9-0.90.9-0.90.91.0-0.61.0
Locomotion distance, session 20.50.72.51.6-1.51.1-1.00.70.70.50.50.5-0.50.5-0.50.50.61.00.4
Locomotion velocity, session 33.54.16.42.5-2.52.3-2.22.02.01.92.12.1-2.12.1-2.12.11.8-0.31.7
Locomotion distance, session 33.63.95.32.1-2.32.3-2.22.22.12.21.91.9-1.91.9-1.91.91.8-1.01.7
Stereotopy head waving bouts, day 31.72.03.6-0.81.0-1.21.2-1.5-1.4-0.9-1.6-1.61.6-1.61.6-1.6-1.51.9-1.5
Stereotopy head waving duration, day 30.10.10.70.2-0.1-0.00.0-0.2-0.20.1-0.3-0.30.3-0.30.3-0.3-0.30.9-0.3
Locomotion velocity, session 72.12.34.51.8-2.01.9-1.81.71.72.11.31.3-1.31.3-1.31.31.2-0.21.1
Locomotion distance, session 74.15.27.52.7-2.72.6-2.62.42.42.12.22.2-2.22.2-2.22.22.2-0.72.1
Stereotopy head waving bouts, day 73.74.24.8-1.91.9-2.02.1-2.1-2.1-1.2-2.2-2.22.2-2.22.2-2.2-2.21.7-2.1
Stereotopy head waving duration, day 73.23.94.5-2.02.0-2.12.1-2.1-2.1-1.0-2.1-2.12.1-2.12.1-2.1-2.11.4-2.0
Locomotion velocity, session 80.10.10.20.4-0.40.3-0.30.20.20.20.20.2-0.20.2-0.20.20.00.50.1
Locomotion distance, session 81.01.42.01.4-1.31.2-1.21.11.10.51.31.3-1.31.3-1.31.31.1-0.21.1
Degree of sensitization distance0.20.20.6-0.20.4-0.50.4-0.5-0.5-0.7-0.4-0.40.4-0.40.4-0.4-0.40.7-0.3
Degree of sensitization stereotypy3.53.84.4-2.02.0-2.12.1-2.1-2.1-1.4-2.0-2.02.0-2.02.0-2.0-2.01.2-1.9
Conditioned locomotion0.10.10.60.4-0.50.5-0.50.50.50.80.00.0-0.00.0-0.00.00.20.00.3
Cocaine response after cond. corrected0.40.40.7-0.20.3-0.40.4-0.5-0.50.1-0.8-0.80.8-0.80.8-0.8-0.60.8-0.6
Cocaine response after cond. not corrected0.10.10.40.2-0.10.0-0.0-0.1-0.10.5-0.4-0.40.4-0.40.4-0.4-0.20.6-0.3
Cocaine response before conditioning2.12.53.01.6-1.71.7-1.61.61.61.21.71.7-1.71.7-1.71.71.4-0.71.4
Saline control response0.20.21.20.3-0.50.6-0.60.70.71.10.10.1-0.10.1-0.10.10.4-0.50.4
Bone: connectivity density0.20.43.4-0.90.8-0.40.30.00.10.00.20.2-0.20.2-0.20.20.2-1.80.5
Bone: cortical apparent density1.52.05.8-0.50.5-0.90.9-1.1-1.1-1.3-1.6-1.61.6-1.61.6-1.6-1.62.4-1.6
Bone: cortical area0.71.03.7-1.91.8-1.31.1-0.7-0.7-0.3-0.7-0.70.7-0.70.7-0.7-0.5-1.4-0.4
Bone: cortical porosity0.80.82.00.6-0.70.9-0.91.11.11.00.80.8-0.80.8-0.80.81.0-1.41.1
Bone: cortical porosity0.80.91.40.7-0.91.0-1.11.21.21.10.80.8-0.80.8-0.80.80.9-1.21.1
Bone: cortical thickness0.20.31.1-1.01.0-0.70.6-0.4-0.4-0.4-0.3-0.30.3-0.30.3-0.3-0.2-0.8-0.2
Bone: cortical thickness0.40.41.30.6-0.60.7-0.70.70.71.10.60.6-0.60.6-0.60.60.5-0.40.6
Bone: cortical tissue density1.41.85.8-0.30.3-0.70.8-1.0-1.0-1.2-1.5-1.51.5-1.51.5-1.5-1.62.4-1.5
Condit. Reinf. active minus inactive responses0.00.00.1-0.00.1-0.10.1-0.1-0.10.3-0.2-0.20.2-0.20.2-0.2-0.10.00.1
Condit. Reinf. active-inactive response ratio0.30.31.20.1-0.10.3-0.30.40.41.10.40.4-0.40.4-0.40.40.5-0.90.6
Condit. Reinf. active responses0.00.00.20.4-0.20.1-0.0-0.1-0.1-0.1-0.1-0.10.1-0.10.1-0.1-0.10.40.1
Condit. Reinf. inactive responses0.30.31.90.9-0.70.3-0.2-0.1-0.1-1.1-0.3-0.30.3-0.30.3-0.3-0.31.4-0.1
Incentive salience index mean0.20.20.4-0.50.6-0.60.6-0.6-0.6-0.4-0.5-0.50.5-0.50.5-0.5-0.40.0-0.3
Condit. Reinf. lever presses1.01.42.2-1.31.5-1.41.4-1.4-1.4-1.3-1.0-1.01.0-1.01.0-1.0-1.10.5-1.0
Condit. Reinf. active minus inactive responses0.70.91.6-1.21.3-1.21.1-1.0-1.0-1.3-0.8-0.80.8-0.80.8-0.8-0.70.2-0.7
Condit. Reinf. active-inactive response ratio0.30.30.8-0.80.9-0.70.7-0.6-0.6-0.6-0.4-0.40.4-0.40.4-0.4-0.3-0.1-0.3
Condit. Reinf. active responses0.50.70.9-0.90.9-0.90.9-0.8-0.8-0.9-0.7-0.70.7-0.70.7-0.7-0.80.6-0.8
Condit. Reinf. inactive responses0.10.11.00.0-0.1-0.10.1-0.2-0.2-0.4-0.3-0.30.3-0.30.3-0.3-0.51.0-0.6
Condit. Reinf. lever presses0.60.91.00.7-0.80.9-0.91.01.00.21.01.0-1.01.0-1.01.01.0-0.91.0
Condit. Reinf. lever reinforcers received0.10.10.3-0.30.3-0.30.3-0.3-0.3-0.6-0.2-0.20.2-0.20.2-0.2-0.30.4-0.3
Conditioned reinforcement - actives0.10.10.90.5-0.50.3-0.30.10.10.50.20.2-0.20.2-0.20.2-0.10.9-0.3
Conditioned reinforcement - inactives0.30.41.10.9-1.00.8-0.70.60.61.00.40.4-0.40.4-0.40.40.30.50.1
Conditioned locomotion0.80.91.50.9-0.80.8-0.80.80.81.21.21.1-1.11.1-1.11.10.8-0.40.9
Patch foraging indifference point 0 sec1.01.64.31.9-2.11.7-1.61.41.41.20.90.9-0.90.9-0.90.90.90.90.6
Patch foraging indifference point AUC0.30.41.0-0.30.4-0.50.6-0.7-0.7-0.7-0.6-0.60.6-0.60.6-0.6-0.51.0-0.7
Delay disc. indifference point, 0s delay0.20.20.9-0.80.8-0.60.5-0.4-0.4-0.6-0.2-0.20.2-0.20.2-0.2-0.0-1.0-0.1
Delay disc. indifference point, 16s delay0.10.10.4-0.50.5-0.30.3-0.2-0.2-0.30.00.0-0.00.0-0.00.0-0.0-0.60.0
Delay disc. indifference point, 2s delay5.96.57.1-2.52.5-2.62.6-2.6-2.6-2.6-2.7-2.72.7-2.72.7-2.7-2.51.7-2.5
Delay disc. indifference point, 24s delay0.10.10.4-0.40.5-0.40.4-0.4-0.4-0.70.00.0-0.00.0-0.00.0-0.1-0.3-0.0
Delay disc. indifference point, 4s delay0.30.30.7-0.70.8-0.60.6-0.5-0.5-0.8-0.4-0.40.4-0.40.4-0.4-0.4-0.4-0.2
Delay disc. indifference point, 8s delay0.20.21.5-0.20.3-0.0-0.10.20.20.00.30.3-0.30.3-0.30.30.3-1.20.5
Indifference point function ln k0.40.62.1-1.51.4-1.00.9-0.6-0.5-0.1-0.3-0.30.3-0.30.3-0.3-0.5-1.3-0.0
Indifference point function log k0.40.62.1-1.51.4-1.00.9-0.6-0.5-0.1-0.3-0.30.3-0.30.3-0.3-0.5-1.3-0.0
Patch foraging total patch changes 0 sec1.42.25.12.1-2.32.0-1.81.71.71.51.21.2-1.21.2-1.21.21.20.60.9
Patch foraging total patch changes 12 sec0.70.92.71.6-1.61.2-1.10.90.90.30.50.5-0.50.5-0.50.50.61.30.3
Patch foraging total patch changes 18 sec1.21.64.32.0-2.11.7-1.51.31.30.61.01.0-1.01.0-1.01.01.11.00.6
Patch foraging total patch changes 24 sec0.81.02.21.4-1.51.2-1.10.90.90.70.90.9-0.90.9-0.90.90.60.80.3
Patch foraging total patch changes 6 sec1.01.43.91.9-2.01.6-1.41.11.10.70.90.9-0.90.9-0.90.90.91.30.4
Patch foraging time to switch 0 sec0.20.32.50.5-0.60.3-0.1-0.0-0.1-0.2-0.5-0.50.5-0.50.5-0.5-0.51.6-0.7
Patch foraging water rate 0 sec0.20.42.4-1.01.0-0.60.4-0.2-0.20.10.30.3-0.30.3-0.30.30.2-1.60.5
Patch foraging water rate 12 sec0.30.53.3-0.50.5-0.10.00.20.20.20.80.8-0.80.8-0.80.80.6-1.80.7
Patch foraging water rate 18 sec0.00.00.1-0.10.2-0.10.00.00.0-0.30.00.0-0.00.0-0.00.00.1-0.20.1
Patch foraging water rate 24 sec0.40.61.9-1.41.4-1.10.9-0.7-0.7-0.7-0.5-0.50.5-0.50.5-0.5-0.5-0.8-0.3
Patch foraging water rate 6 sec0.40.65.1-1.21.2-0.70.5-0.2-0.2-0.20.30.3-0.30.3-0.30.30.4-2.30.6
Seeking ratio, delayed vs. immediate footshock0.20.30.6-0.70.8-0.70.6-0.5-0.5-0.7-0.5-0.40.4-0.40.4-0.4-0.4-0.3-0.2
Distance traveled before self-admin0.30.31.11.0-1.00.8-0.70.60.60.40.30.3-0.30.3-0.30.30.50.50.3
Distance traveled after self-admin1.71.92.21.4-1.41.4-1.41.31.41.21.51.5-1.51.5-1.51.51.3-0.71.4
Extensor digitorum longus weight7.529.537.2-6.16.0-5.95.7-5.5-5.5-4.2-5.6-5.65.6-5.65.6-5.6-5.52.9-5.2
Bone: elastic displacement5.25.911.13.3-3.22.9-2.82.52.52.12.22.2-2.22.2-2.22.22.2-0.02.2
Bone: elastic work2.63.34.11.7-1.61.7-1.81.81.81.22.02.0-2.02.0-2.02.02.0-1.52.0
Bone: endosteal estimation0.51.24.9-2.22.0-1.31.1-0.6-0.60.6-0.4-0.40.4-0.40.4-0.4-0.3-2.1-0.2
Bone: endosteal perimeter1.02.06.9-2.62.4-1.91.7-1.2-1.2-0.5-1.1-1.11.1-1.11.1-1.1-1.0-1.4-0.9
Epididymis fat weight2.55.98.51.7-1.72.1-2.32.52.52.32.52.5-2.52.5-2.52.52.7-2.92.8
Delta time in closed arm before/after self-admin0.10.10.20.0-0.10.1-0.20.20.20.00.30.3-0.30.3-0.30.30.2-0.50.3
Delta time in open arm before/after self-admin4.54.45.62.4-2.42.3-2.32.22.21.82.12.1-2.12.1-2.12.11.9-0.81.9
Diff in mean of infusions in LGA sessions1.41.52.8-1.71.6-1.51.4-1.3-1.3-1.0-1.1-1.11.1-1.11.1-1.1-1.40.3-1.1
Delay discount exponential model param0.30.30.70.7-0.80.6-0.60.50.50.90.30.3-0.30.3-0.30.30.40.40.3
Extinction: sum of active levers before priming0.90.91.6-1.31.3-1.21.1-1.0-1.0-1.1-0.7-0.70.7-0.70.7-0.7-1.00.1-0.7
Active lever presses in extinction session 60.20.20.70.2-0.10.2-0.30.30.30.80.40.4-0.40.4-0.40.40.5-0.50.4
Bone: final force0.71.17.4-2.01.8-1.10.9-0.3-0.3-0.10.10.1-0.10.1-0.10.10.2-2.70.4
Bone: final moment0.71.18.5-2.01.8-1.10.8-0.2-0.20.10.20.2-0.20.2-0.20.20.3-2.90.5
Food consumed during 24 hour testing period0.81.04.10.00.00.4-0.50.80.80.61.01.0-1.01.0-1.01.01.2-2.01.4
Glucose0.00.00.00.0-0.10.1-0.00.00.0-0.20.00.0-0.00.0-0.00.00.0-0.10.0
Heart weight0.00.10.2-0.1-0.10.2-0.20.30.30.50.00.0-0.00.0-0.00.00.2-0.40.2
Delay discount hyperbolic model param0.50.61.20.9-1.00.9-0.90.80.81.10.60.6-0.60.6-0.60.60.60.10.5
Intermittent access intake day 1-15 change1.61.52.01.1-1.21.2-1.21.31.31.11.31.4-1.41.4-1.41.41.1-0.81.1
Intermittent access intake escalation2.22.12.81.1-1.21.3-1.41.51.51.21.61.7-1.71.7-1.71.71.4-1.21.4
Intermittent access intake escalation 21.41.41.80.9-1.01.1-1.11.21.20.91.21.3-1.31.3-1.31.31.2-1.11.1
Intermitt. access day 1 inactive lever presses0.30.30.60.6-0.70.6-0.60.60.60.80.50.6-0.60.6-0.60.60.4-0.10.4
Intermitt. access day 15 inactive lever presses0.60.70.90.9-0.90.9-0.90.90.90.70.80.8-0.80.8-0.80.80.8-0.50.8
Intermitt. access escalation Index0.80.71.8-0.20.3-0.60.7-0.9-0.9-0.9-1.0-0.80.8-0.80.8-0.8-0.81.3-0.9
Intermittent access day 1 total infusions0.40.53.70.9-1.00.8-0.80.60.61.90.30.3-0.30.3-0.30.30.30.40.2
Intermittent access day 15 total infusions1.61.84.61.6-1.71.6-1.51.41.42.21.21.2-1.21.2-1.21.21.0-0.11.0
Intermittent access terminal intake (last 3 days)0.91.03.91.3-1.31.2-1.21.01.02.00.70.7-0.70.7-0.70.70.60.30.5
Intermittent access total infusions0.91.04.71.3-1.41.2-1.21.01.02.20.70.6-0.60.6-0.60.60.60.20.6
Intermittent access day 1 locomotion1.51.63.81.6-1.61.5-1.51.31.32.01.11.1-1.11.1-1.11.11.0-0.21.0
Intermittent access day 15 total locomotion3.13.34.31.8-1.91.9-1.91.91.92.11.81.8-1.81.8-1.81.81.8-1.21.7
Intermittent access total locomotion2.52.84.92.2-2.22.0-2.01.81.82.21.61.5-1.51.5-1.51.51.40.01.2
Intermittent access standard deviation2.22.43.01.1-1.21.4-1.41.51.51.51.51.7-1.71.7-1.71.71.6-1.71.5
Left kidney weight0.10.31.4-1.21.0-0.80.6-0.3-0.3-0.2-0.2-0.20.2-0.20.2-0.2-0.4-0.9-0.1
Right kidney weight0.61.64.5-2.12.0-1.71.6-1.2-1.2-1.2-0.9-0.90.9-0.90.9-0.9-0.8-1.0-0.7
Cocaine induced anxiety0.30.31.4-0.20.00.2-0.30.50.50.60.50.5-0.50.5-0.50.50.5-1.20.6
Post-drug Anxiety0.40.52.0-1.41.3-0.90.7-0.4-0.4-0.0-0.2-0.20.2-0.20.2-0.2-0.2-1.4-0.1
Baseline Anxiety0.20.20.6-0.60.7-0.50.5-0.4-0.4-0.8-0.2-0.20.2-0.20.2-0.2-0.1-0.4-0.1
Tail length0.20.52.10.5-0.80.9-1.01.11.01.40.30.2-0.20.2-0.20.20.4-0.80.6
Length with tail0.10.43.5-1.01.0-0.50.4-0.1-0.1-0.1-0.2-0.20.2-0.20.2-0.20.0-1.90.3
Length without tail0.61.34.1-1.92.0-1.51.4-1.1-1.1-1.3-0.5-0.50.5-0.50.5-0.5-0.4-1.6-0.2
Times rat made contact with spout0.30.31.10.4-0.40.5-0.50.60.60.40.50.5-0.50.5-0.50.50.9-1.00.8
Lifetime Intake1.92.17.41.8-1.91.7-1.71.51.52.71.21.1-1.11.1-1.11.11.1-0.11.1
Liver weight, left0.20.42.9-0.40.40.0-0.10.40.40.80.40.4-0.40.4-0.40.40.6-1.70.7
Liver weight, right0.40.63.5-0.30.20.2-0.30.60.60.70.70.7-0.70.7-0.70.70.9-1.91.0
Locomotor activity0.20.30.80.9-0.80.7-0.60.60.60.00.30.3-0.30.3-0.30.30.50.20.4
Locomotor testing distance0.61.02.81.7-1.71.5-1.31.21.20.50.60.6-0.60.6-0.60.61.10.20.9
Locomotor testing rearing0.50.82.01.2-1.41.3-1.21.21.20.70.50.5-0.50.5-0.50.50.9-0.20.8
Locomotion in novel chamber1.62.03.7-1.91.9-1.71.6-1.4-1.4-0.8-1.4-1.41.4-1.41.4-1.4-1.50.1-1.3
Locomotion in novel chamber post-restriction0.50.51.30.3-0.30.5-0.60.70.70.70.80.8-0.80.8-0.80.80.8-1.10.9
Fecal boli incidents, locomotor time 13.13.43.91.9-1.81.9-1.91.91.91.91.81.9-1.91.9-1.91.92.0-1.32.0
Change in fecal boli incidents, locomotor task1.41.31.6-1.01.0-1.11.2-1.2-1.2-1.0-1.1-1.11.1-1.11.1-1.1-1.21.1-1.3
Time >=10cm from walls, locomotor time 10.30.30.50.7-0.70.6-0.70.60.60.70.50.5-0.50.5-0.50.50.30.20.4
Bouts of movement, locomotor time 10.00.00.20.00.2-0.10.2-0.2-0.2-0.4-0.0-0.00.0-0.00.0-0.00.1-0.30.1
Total resting periods, locomotor time 10.10.10.30.6-0.40.3-0.20.10.10.10.20.2-0.20.2-0.20.20.3-0.00.3
Rest time, locomotor task time 10.10.10.50.7-0.60.5-0.40.30.30.40.30.3-0.30.3-0.30.30.30.10.3
Distance moved, locomotor task time 10.20.20.4-0.30.3-0.30.3-0.4-0.4-0.3-0.5-0.40.4-0.40.4-0.4-0.40.6-0.5
Vertical activity count, locomotor time 11.01.01.7-1.31.2-1.21.1-1.0-1.0-0.9-1.0-1.01.0-1.01.0-1.0-1.10.6-1.1
Time >=10cm from walls, locomotor time 20.30.40.60.8-0.80.8-0.70.70.70.70.50.5-0.50.5-0.50.50.6-0.20.5
Bouts of movement, locomotor time 21.11.22.2-1.51.4-1.31.1-1.0-0.9-0.7-1.1-1.11.1-1.11.1-1.1-1.10.0-0.8
Total resting periods, locomotor time 21.92.03.3-1.81.7-1.61.5-1.3-1.3-1.1-1.4-1.51.5-1.51.5-1.5-1.40.2-1.1
Rest time, locomotor task time 20.00.10.3-0.00.1-0.20.2-0.3-0.3-0.0-0.2-0.20.2-0.20.2-0.2-0.30.5-0.3
Distance moved, locomotor task time 20.00.00.10.1-0.10.00.0-0.1-0.1-0.4-0.2-0.20.2-0.20.2-0.2-0.00.2-0.0
Vertical activity count, locomotor time 20.10.10.6-0.20.2-0.20.2-0.1-0.1-0.8-0.2-0.10.1-0.10.1-0.1-0.0-0.0-0.0
Light reinforcement 10.10.20.60.8-0.60.4-0.30.20.2-0.40.40.4-0.40.4-0.40.40.30.60.1
Light reinforcement 20.10.11.3-0.20.3-0.30.3-0.3-0.3-1.2-0.1-0.10.1-0.10.1-0.1-0.0-0.1-0.2
Bone: marrow area0.51.14.6-2.11.9-1.31.1-0.6-0.60.6-0.4-0.40.4-0.40.4-0.4-0.3-2.0-0.2
Bone: maximum diameter0.40.72.0-1.41.3-1.00.9-0.7-0.7-0.3-0.8-0.80.8-0.80.8-0.8-0.6-0.5-0.6
Bone: maximum force1.11.97.3-2.72.6-1.91.6-1.0-1.0-0.7-0.5-0.50.5-0.50.5-0.5-0.4-2.4-0.2
Bone: maximum moment1.01.87.3-2.72.5-1.81.5-0.9-0.8-0.5-0.4-0.40.4-0.40.4-0.4-0.3-2.6-0.0
Mean time between licks in bursts0.60.81.41.2-0.90.9-0.80.70.70.01.01.0-1.01.0-1.01.00.7-0.31.0
Mean num. licks in bursts0.50.62.10.1-0.30.6-0.60.90.90.50.70.7-0.70.7-0.70.70.7-1.51.1
Cd content in liver0.40.50.70.9-0.80.7-0.70.60.60.90.60.6-0.60.6-0.60.60.9-0.10.6
Co content in liver0.00.10.10.1-0.10.2-0.10.20.20.40.30.3-0.30.3-0.30.3-0.0-0.30.2
Cu content in liver0.00.10.4-0.50.3-0.20.20.0-0.00.20.10.1-0.10.1-0.10.1-0.2-0.6-0.1
Fe content in liver0.20.30.70.8-0.80.7-0.60.50.50.70.30.3-0.30.3-0.30.30.4-0.10.3
K content in liver0.20.20.40.3-0.20.3-0.20.30.3-0.20.50.5-0.50.5-0.50.50.6-0.50.4
Mg content in liver0.30.30.50.5-0.40.3-0.30.30.3-0.30.70.7-0.70.7-0.70.70.6-0.30.6
Mn content in liver0.10.20.4-0.60.6-0.60.6-0.5-0.5-0.5-0.2-0.20.2-0.20.2-0.2-0.2-0.0-0.3
Na content in liver0.00.00.4-0.1-0.00.10.00.10.0-0.6-0.0-0.00.0-0.00.0-0.00.2-0.1-0.1
Rb content in liver0.81.01.71.2-1.31.2-1.11.11.00.81.01.0-1.01.0-1.01.00.8-0.00.8
Se content in liver0.30.31.01.0-0.90.7-0.60.50.50.70.50.5-0.50.5-0.50.50.50.20.5
Sr content in liver1.41.32.00.7-0.81.0-1.01.11.11.11.21.2-1.21.2-1.21.21.1-1.41.1
Zn content in liver1.61.82.81.7-1.61.4-1.41.21.20.91.51.5-1.51.5-1.51.51.1-0.11.2
Bone: minimum diameter0.91.75.7-2.42.2-1.71.5-1.1-1.10.1-1.0-1.01.0-1.01.0-1.0-0.8-1.5-0.6
Time in familiar zone, hab. session 10.00.00.20.10.1-0.10.1-0.1-0.1-0.50.00.0-0.00.0-0.00.00.1-0.20.4
Time in novel zone, hab. session 10.40.41.1-0.60.5-0.50.5-0.6-0.6-0.3-0.6-0.60.6-0.60.6-0.6-0.81.0-1.0
Total zone transitions, hab. session 11.52.14.9-0.91.1-1.31.4-1.6-1.6-2.2-1.4-1.41.4-1.41.4-1.4-1.41.5-1.4
Total locomotion distance, hab. session 10.10.10.50.4-0.30.1-0.0-0.1-0.1-0.70.00.0-0.00.0-0.00.00.10.6-0.0
Locomotion velocity, hab. session 10.00.10.60.3-0.20.10.0-0.1-0.1-0.70.10.1-0.10.1-0.10.10.10.40.1
Time in familiar zone, hab. session 20.10.11.1-0.40.5-0.30.2-0.0-0.00.10.20.2-0.20.2-0.20.20.2-1.00.6
Time in novel zone, hab. session 20.30.32.60.3-0.40.10.0-0.2-0.2-0.2-0.5-0.50.5-0.50.5-0.5-0.71.6-0.9
Total zone transitions, hab. session 20.00.10.20.4-0.30.3-0.20.10.1-0.10.20.2-0.20.2-0.20.20.40.00.1
Total locomotion distance, hab. session 20.20.20.60.8-0.70.6-0.60.40.40.20.40.4-0.40.4-0.40.40.50.30.3
Locomotion velocity, hab. session 20.30.30.60.8-0.70.7-0.60.60.60.20.60.6-0.60.6-0.60.60.7-0.10.5
Novel to familiar place preference ratio2.52.53.4-1.81.8-1.81.8-1.7-1.7-1.3-1.6-1.61.6-1.61.6-1.6-1.60.5-1.6
Novelty place preference2.02.02.5-1.61.6-1.61.6-1.5-1.6-1.2-1.4-1.41.4-1.41.4-1.4-1.50.5-1.4
Time in novel zone, NPP test2.12.22.5-1.51.5-1.61.6-1.6-1.6-1.3-1.5-1.51.5-1.51.5-1.5-1.60.7-1.5
Total zone transitions, NPP test0.30.41.41.2-1.00.7-0.60.30.3-0.70.40.4-0.40.4-0.40.40.50.90.1
Total locomotion distance, NPP test1.11.64.12.0-1.81.5-1.41.11.10.01.21.2-1.21.2-1.21.21.30.50.9
Locomotion velocity, NPP test1.21.63.61.9-1.71.5-1.41.11.10.11.31.3-1.31.3-1.31.31.40.11.1
Intraocular pressure2.02.85.42.3-2.32.0-2.01.81.81.11.61.6-1.61.6-1.61.61.30.31.4
Delta distance traveled before/after self-admin2.62.84.01.0-1.11.3-1.41.61.61.61.91.9-1.91.9-1.91.91.7-2.01.8
Delta ambulatory time before/after self-admin2.83.13.91.2-1.21.5-1.61.71.71.71.91.9-1.91.9-1.91.91.8-2.01.9
Parametrial fat weight2.65.16.02.4-2.32.2-2.32.22.31.82.42.4-2.42.4-2.42.42.1-1.02.4
Pavlov. Cond. lever latency1.11.41.91.4-1.41.4-1.41.31.31.41.01.0-1.01.0-1.01.01.1-0.61.2
Pavlov. Cond. magazine entry latency2.22.83.6-1.91.8-1.81.8-1.7-1.7-1.4-1.7-1.71.7-1.71.7-1.7-1.71.0-1.7
Pavlov. Cond. change in total contacts2.83.04.4-2.12.1-2.02.0-1.9-1.9-1.5-1.6-1.61.6-1.61.6-1.6-1.70.8-1.7
Pavlov. Cond. index score2.83.54.9-2.22.1-2.12.1-2.0-2.0-1.8-1.8-1.81.8-1.81.8-1.8-1.80.9-1.9
Pavlov. Cond. latency score2.53.14.4-2.12.0-2.02.0-1.9-1.9-1.7-1.7-1.71.7-1.71.7-1.7-1.70.9-1.8
Pavlov. Cond. lever contacts0.80.91.5-1.21.2-1.11.1-1.1-1.1-1.1-0.8-0.80.8-0.80.8-0.8-0.90.4-1.1
Pavlov. Cond. magazine entry number0.81.01.61.2-1.21.1-1.11.01.00.60.90.9-0.90.9-0.90.91.0-0.51.1
Pavlov. Cond. intertrial magazine entries2.12.55.02.2-2.21.9-1.81.61.60.71.61.6-1.61.6-1.61.61.50.31.3
Pavlov. Cond. lever-magazine prob. diff.2.73.34.9-2.22.2-2.12.1-2.0-2.0-1.7-1.7-1.71.7-1.71.7-1.7-1.70.8-1.9
Pavlov. Cond. response bias0.70.91.4-1.21.1-1.11.1-1.0-1.0-0.8-0.8-0.80.8-0.80.8-0.8-0.90.6-1.1
Pavlov. Cond. lever latency1.21.62.3-1.51.4-1.41.4-1.3-1.3-0.3-1.3-1.31.3-1.31.3-1.3-1.40.6-1.2
Pavlov. Cond. magazine entry latency1.61.82.51.5-1.31.4-1.41.31.30.91.31.3-1.31.3-1.31.31.5-1.01.6
Pavlov. Cond. change in total contacts1.01.33.2-1.31.4-1.31.3-1.3-1.3-1.8-0.9-0.90.9-0.90.9-0.9-1.00.5-1.1
Pavlov. Cond. index score1.01.31.91.4-1.21.2-1.21.11.10.41.11.1-1.11.1-1.11.11.3-0.81.2
Pavlov. Cond. latency score0.91.11.61.3-1.11.1-1.11.01.00.31.01.0-1.01.0-1.01.01.2-0.71.1
Pavlov. Cond. lever contacts1.52.12.91.7-1.61.6-1.61.51.50.51.41.4-1.41.4-1.41.41.6-0.81.5
Pavlov. Cond. magazine entry number0.50.60.9-0.80.7-0.70.7-0.7-0.7-0.2-0.9-0.90.9-0.90.9-0.9-0.90.7-0.9
Pavlov. Cond. intertrial magazine entries1.52.04.81.4-1.61.6-1.61.71.72.21.21.2-1.21.2-1.21.21.3-0.71.3
Pavlov. Cond. lever-magazine prob. diff.0.50.61.01.0-0.80.8-0.80.80.80.10.80.8-0.80.8-0.80.81.0-0.70.9
Pavlov. Cond. response bias1.92.63.21.7-1.61.6-1.61.61.60.61.71.7-1.71.7-1.71.71.8-1.11.7
Time in closed arm before self-admin1.41.51.9-1.41.4-1.41.4-1.3-1.3-1.2-1.3-1.31.3-1.31.3-1.3-1.00.6-1.2
Time in closed arm after self-admin1.61.62.6-1.21.2-1.31.3-1.3-1.3-1.6-1.3-1.31.3-1.31.3-1.3-1.10.9-1.2
Time in open arm before self-admin2.12.22.6-1.21.3-1.51.5-1.6-1.6-1.3-1.5-1.51.5-1.51.5-1.5-1.61.5-1.6
Time in open arm after self-admin0.10.10.10.4-0.30.2-0.20.10.10.30.20.2-0.20.2-0.20.20.00.30.1
Bone: periosteal estimation0.81.76.8-2.62.3-1.61.4-0.8-0.80.2-0.7-0.70.7-0.70.7-0.7-0.5-2.3-0.4
Bone: periosteal perimeter2.03.39.0-3.02.8-2.32.1-1.6-1.6-0.9-1.6-1.61.6-1.61.6-1.6-1.5-0.9-1.3
Bone: post-yield work0.60.83.1-1.81.6-1.10.9-0.6-0.6-0.4-0.3-0.30.3-0.30.3-0.3-0.2-1.7-0.1
Progressive ratio test 1 active lever presses4.04.17.72.7-2.82.5-2.42.12.12.71.81.8-1.81.8-1.81.81.50.41.3
Progressive ratio test 1 breakpoint2.83.06.02.4-2.42.1-2.01.81.72.51.41.4-1.41.4-1.41.41.20.51.0
Progressive ratio test 1 inactive lever presses0.70.81.81.3-1.41.2-1.10.90.90.90.70.7-0.70.7-0.70.70.60.30.5
Progressive ratio test 2 active lever presses1.31.43.51.4-1.51.4-1.41.31.31.91.11.0-1.01.0-1.01.00.9-0.00.8
Progressive ratio test 2 breakpoint1.11.33.31.4-1.51.3-1.31.21.21.81.01.0-1.01.0-1.01.00.80.00.7
Progressive ratio test 2 inactive lever presses1.41.64.11.5-1.61.5-1.51.41.42.01.11.0-1.01.0-1.01.01.1-0.41.0
Incentive Sensitization - Responses0.30.30.6-0.80.7-0.60.6-0.4-0.5-0.3-0.5-0.50.5-0.50.5-0.5-0.6-0.1-0.6
Incentive Sensitization - Breakpoint0.40.40.8-0.90.7-0.70.7-0.6-0.6-0.4-0.7-0.60.6-0.60.6-0.6-0.70.1-0.7
Sum of active levers in priming session hrs 5-60.10.10.30.6-0.50.4-0.30.20.20.40.20.2-0.20.2-0.20.20.10.40.1
Progressive ratio0.30.41.01.0-0.90.8-0.70.60.60.60.60.5-0.50.5-0.50.50.60.30.5
Food seeking constrained by brief footshock0.60.81.91.4-1.31.2-1.10.90.91.00.60.6-0.60.6-0.60.60.80.20.7
Seeking ratio, punishment vs. effort0.00.00.1-0.20.1-0.10.00.00.0-0.1-0.1-0.00.0-0.00.0-0.00.0-0.30.1
Retroperitoneal fat weight2.27.18.62.8-2.62.6-2.62.62.61.82.92.9-2.92.9-2.92.92.9-1.62.7
Reaction time number correct0.40.62.0-0.40.10.2-0.30.60.61.40.90.9-0.90.9-0.90.90.4-1.40.5
Reaction time mean minus median0.50.72.41.4-1.51.2-1.10.90.90.60.50.5-0.50.5-0.50.50.61.00.2
Reaction time mean minus median AUC0.20.31.40.9-1.00.7-0.50.40.40.10.00.0-0.00.0-0.00.00.11.2-0.2
Reaction time num false alarms0.10.21.30.9-0.70.4-0.30.10.1-0.10.10.1-0.10.1-0.10.10.11.1-0.0
Reaction time num false alarms AUC0.20.21.90.7-0.50.2-0.1-0.2-0.1-0.4-0.2-0.20.2-0.20.2-0.2-0.11.4-0.2
Reaction time trials correct on left0.40.62.0-0.40.10.2-0.30.60.61.40.90.9-0.90.9-0.90.90.4-1.40.5
Reaction time trials on left0.50.71.9-0.3-0.00.3-0.40.70.71.40.90.9-0.90.9-0.90.90.4-1.30.6
Reaction time mean0.10.20.50.6-0.70.6-0.60.60.50.70.10.1-0.10.1-0.10.10.10.30.1
Reaction time mean AUC0.10.10.30.4-0.50.5-0.50.50.40.60.00.0-0.00.0-0.00.00.10.20.0
Median of all reaction times0.00.10.40.2-0.30.3-0.30.30.30.6-0.0-0.00.0-0.00.0-0.0-0.0-0.10.1
Reaction time omissions1.72.36.02.4-2.52.1-1.91.71.61.01.11.1-1.11.1-1.11.11.20.90.9
Reaction time false alarm rate0.60.83.90.5-0.1-0.30.4-0.8-0.7-1.4-0.9-0.90.9-0.90.9-0.9-0.62.0-0.8
Reaction time premature initiation rate2.02.65.12.3-2.32.0-1.91.81.81.41.31.3-1.31.3-1.31.31.7-0.11.5
Reaction time premature initiations2.43.44.41.9-2.12.1-2.02.02.02.11.71.7-1.71.7-1.71.71.8-0.91.7
Std. dev. reaction times0.40.61.91.3-1.41.0-0.90.70.70.40.30.3-0.30.3-0.30.30.41.20.0
Reaction time trials completed0.50.71.9-0.3-0.00.3-0.40.70.71.40.90.9-0.90.9-0.90.90.4-1.30.6
Reaction time trials AUC0.30.41.9-0.60.30.0-0.10.40.41.10.70.7-0.70.7-0.70.70.2-1.40.4
Run reversals in cocaine runway, females0.10.10.30.0-0.20.2-0.30.40.40.60.30.3-0.30.3-0.30.30.2-0.40.4
Run reversals in cocaine runway, males1.91.84.1-0.70.6-0.91.0-1.1-1.2-1.1-1.5-1.51.5-1.51.5-1.5-1.42.0-1.7
Latency to leave start box in cocaine runway0.70.81.3-0.40.7-0.80.9-1.0-1.0-1.1-0.9-0.90.9-0.90.9-0.9-0.70.8-0.7
Latency to leave start box in cocaine runway, F0.60.73.10.20.0-0.30.5-0.8-0.8-1.0-0.9-0.90.9-0.90.9-0.9-0.71.8-0.9
Latency to leave start box in cocaine runway, M0.40.41.2-1.01.1-0.80.8-0.6-0.6-0.5-0.5-0.50.5-0.50.5-0.5-0.2-0.8-0.2
Std. dev. time between licks in bursts0.91.11.81.3-1.21.1-1.00.90.90.31.21.2-1.21.2-1.21.21.0-0.30.8
Total sessions with >9 infusions0.80.92.31.3-1.31.2-1.21.01.01.50.70.6-0.60.6-0.60.60.60.30.6
Short access day 1 total inactive lever presses0.60.61.41.2-1.11.0-1.00.90.91.10.50.5-0.50.5-0.50.50.8-0.00.8
Short access day 10 total inactive lever presses0.20.20.60.2-0.30.4-0.50.60.60.70.40.3-0.30.3-0.30.30.6-0.80.5
Short access day 1 total infusions0.60.63.50.9-0.90.9-0.90.80.81.90.50.5-0.50.5-0.50.50.5-0.10.5
Short access day 10 total infusions1.21.45.61.7-1.71.5-1.41.21.22.40.70.6-0.60.6-0.60.60.80.30.7
Short access total infusions1.82.07.11.7-1.71.6-1.61.51.52.71.11.0-1.01.0-1.01.01.1-0.31.1
Short access day 1 locomotion0.00.00.10.4-0.30.2-0.20.20.20.30.0-0.10.1-0.10.1-0.10.00.20.1
Short access day 10 total locomotion0.10.10.50.3-0.40.4-0.40.40.30.70.20.1-0.10.1-0.10.10.10.10.1
Short access total locomotion0.20.20.70.7-0.70.6-0.60.50.50.90.20.1-0.10.1-0.10.10.20.20.2
One hour access (0.3 mA shock)0.10.10.4-0.40.3-0.30.2-0.2-0.20.6-0.2-0.30.3-0.30.3-0.3-0.50.2-0.4
Compulsive drug intake1.31.32.2-1.41.5-1.41.3-1.2-1.2-1.4-0.9-1.01.0-1.01.0-1.0-1.10.3-0.9
One hour access (shock baseline)0.10.11.2-0.1-0.10.1-0.10.20.11.1-0.0-0.10.1-0.10.1-0.1-0.1-0.1-0.1
Social response proportion1.41.52.20.9-1.01.1-1.21.31.21.21.21.2-1.21.2-1.21.21.2-1.51.4
Social responses0.30.41.51.2-1.20.9-0.80.50.50.50.20.2-0.20.2-0.20.20.30.90.2
Social time0.81.12.90.5-0.50.8-0.80.90.91.01.11.1-1.11.1-1.11.11.1-1.71.1
Soleus weight0.10.31.0-1.00.9-0.70.6-0.3-0.3-0.8-0.0-0.00.0-0.00.0-0.00.0-1.00.0
Bone: stiffness2.43.712.5-3.53.4-2.72.4-1.8-1.8-1.2-1.2-1.21.2-1.21.2-1.2-1.2-2.0-1.1
Tibialis anterior weight10.034.137.8-6.05.9-6.16.0-5.9-5.8-4.7-6.1-6.16.1-6.16.1-6.1-6.14.1-5.7
Time to tail flick, vehicle, before self-admin0.10.10.30.2-0.10.00.1-0.2-0.2-0.1-0.5-0.50.5-0.50.5-0.5-0.10.5-0.3
Time to tail flick, vehicle, after self-admin0.70.81.1-1.01.0-0.90.9-0.8-0.80.0-1.0-1.01.0-1.01.0-1.0-0.70.2-0.8
Time to tail flick, test, before self-admin0.70.62.0-0.40.4-0.60.6-0.7-0.7-1.4-0.7-0.70.7-0.70.7-0.7-0.71.2-0.9
Time to tail flick, test, after self-admin0.10.10.3-0.50.4-0.30.2-0.1-0.10.1-0.1-0.10.1-0.10.1-0.1-0.2-0.5-0.1
Delta time to tail flick, vehicle, before/after SA0.10.10.6-0.30.3-0.1-0.00.10.10.80.20.2-0.20.2-0.20.20.1-0.70.2
Delta time to tail flick, test, before/after SA0.10.10.9-0.30.2-0.0-0.00.20.20.90.10.1-0.10.1-0.10.10.2-0.90.3
Tibia length0.30.76.3-1.41.2-0.60.30.20.20.9-0.0-0.10.1-0.10.1-0.10.3-2.50.7
Ambulatory time before self-admin0.90.92.41.6-1.51.3-1.21.01.00.60.80.8-0.80.8-0.80.80.80.50.7
Ambulatory time after self-admin3.53.94.52.1-2.12.0-2.02.02.01.62.12.1-2.12.1-2.12.11.9-1.01.9
Bone: tissue strength0.50.51.6-1.01.0-0.90.9-0.7-0.7-1.3-0.4-0.40.4-0.40.4-0.4-0.4-0.0-0.4
Total heroin consumption0.70.82.7-0.0-0.00.3-0.40.70.70.61.11.1-1.11.1-1.11.10.6-1.61.0
Bone: trabecular number0.30.54.6-0.80.6-0.20.10.30.3-0.10.40.4-0.40.4-0.40.40.5-2.10.7
Bone: trabecular spacing0.30.41.60.00.0-0.20.3-0.5-0.5-0.4-0.7-0.70.7-0.70.7-0.7-0.71.3-0.7
Bone: trabecular thickness0.60.70.9-1.00.9-0.90.9-0.8-0.9-0.8-0.8-0.80.8-0.80.8-0.8-0.90.2-0.7
Bone: trabecular tissue density3.04.35.9-1.71.9-2.12.1-2.2-2.2-2.4-2.1-2.12.1-2.12.1-2.1-1.91.7-2.1
Water consumed over 24 hours1.72.03.51.2-1.31.5-1.51.61.71.91.21.2-1.21.2-1.21.21.6-1.31.5
Number of responses in last shaping day0.00.00.1-0.30.3-0.30.3-0.3-0.30.20.10.1-0.10.1-0.10.1-0.30.1-0.2