Hub : Genes

Zfpl1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Liver	alternative TSS	NM_001286936.1	0.02	0.02	9.7e-03	0.01	0.01	0	0.01	5.7e-02	3.9e-02	1.7e-01	5.0e-02
2	Adipose	gene expression	Zfpl1	0.04	0.03	1.6e-03	0.02	0.01	0.01	0.01	2.2e-03	9.8e-03	5.4e-02	9.8e-03
3	Liver	gene expression	Zfpl1	0.07	0.04	2.5e-06	0.02	0.05	0.04	0.04	2.6e-03	6.8e-06	4.2e-05	6.2e-05

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bone: apparent density	0.4	0.6	1.3	1.1	0.7	-0.4
Area under the delay curve	0.2	0.2	0.4	0.1	-0.3	0.7
BMI with tail	2.8	9.0	16.3	4.0	3.0	-1.4
BMI without tail	1.2	2.6	5.5	2.3	1.4	-0.5
Body weight	3.9	16.4	21.4	4.6	4.3	-3.1
Weight adjusted by age	2.5	2.9	3.6	1.6	1.6	-1.9
Bone surface	5.1	9.0	9.8	3.1	2.8	-3.0
Bone volume	1.9	3.3	3.8	1.9	1.5	-1.9
Breakpoint value in progressive ratio session	4.0	4.4	4.7	2.0	2.1	-2.2
Number of licking bursts	0.4	0.5	0.5	0.6	0.7	-0.7
Context. condit. distance diff. score	2.3	2.7	3.3	-1.5	-1.6	1.8
Locomotion velocity, session 1	0.0	0.0	0.1	0.1	0.1	0.3
Locomotion distance, session 1	0.4	0.6	1.2	1.1	0.7	0.1
Locomotion velocity, session 2	2.8	3.3	4.8	2.2	1.8	-1.3
Locomotion distance, session 2	0.6	0.8	1.6	1.3	0.9	-0.1
Locomotion velocity, session 3	0.3	0.4	1.0	-0.0	-0.5	1.0
Locomotion distance, session 3	0.1	0.1	0.1	-0.2	-0.3	0.4
Stereotopy head waving bouts, day 3	0.8	1.0	2.1	-0.4	-0.8	1.4
Stereotopy head waving duration, day 3	0.7	0.9	1.2	-0.7	-1.0	1.1
Locomotion velocity, session 7	0.6	0.7	1.4	-0.2	-0.8	1.2
Locomotion distance, session 7	0.4	0.4	1.3	-0.0	-0.3	1.1
Stereotopy head waving bouts, day 7	0.1	0.1	0.2	-0.2	-0.4	-0.1
Stereotopy head waving duration, day 7	1.3	1.5	1.7	1.3	1.1	-1.3
Locomotion velocity, session 8	0.7	0.8	1.2	1.0	1.1	-0.5
Locomotion distance, session 8	0.2	0.4	0.7	-0.1	-0.5	0.9
Degree of sensitization distance	0.2	0.2	0.4	0.2	-0.0	0.7
Degree of sensitization stereotypy	0.8	0.9	1.5	0.8	0.7	-1.2
Conditioned locomotion	1.7	1.9	2.4	1.4	1.5	-1.2
Cocaine response after cond. corrected	2.2	2.4	3.6	-1.3	-1.5	1.9
Cocaine response after cond. not corrected	1.7	1.8	2.8	-1.1	-1.3	1.7
Cocaine response before conditioning	1.0	1.2	1.6	0.9	1.0	-1.3
Saline control response	4.1	5.4	6.9	2.5	2.6	-1.8
Bone: connectivity density	2.3	3.6	5.1	2.3	1.9	-1.5
Bone: cortical apparent density	0.2	0.3	0.4	0.4	0.7	-0.4
Bone: cortical area	0.8	1.3	1.8	1.0	1.0	-1.4
Bone: cortical porosity	0.1	0.1	0.2	0.5	0.3	-0.1
Bone: cortical porosity	0.6	0.7	1.0	1.0	0.9	-0.6
Bone: cortical thickness	2.3	3.7	4.5	1.8	2.1	-1.8
Bone: cortical thickness	0.2	0.3	0.5	0.5	0.7	-0.2
Bone: cortical tissue density	0.3	0.4	0.6	0.5	0.8	-0.5
Condit. Reinf. active minus inactive responses	0.1	0.1	0.2	0.5	0.4	-0.1
Condit. Reinf. active-inactive response ratio	0.0	0.0	0.0	0.1	0.1	-0.1
Condit. Reinf. active responses	0.0	0.0	0.1	0.3	0.2	0.0
Condit. Reinf. inactive responses	0.0	0.0	0.1	0.0	-0.1	0.2
Incentive salience index mean	0.3	0.3	0.7	0.8	0.6	-0.1
Condit. Reinf. lever presses	0.4	0.5	0.8	0.9	0.7	-0.5
Condit. Reinf. active minus inactive responses	0.1	0.1	0.1	-0.3	-0.4	-0.1
Condit. Reinf. active-inactive response ratio	0.4	0.4	0.7	-0.7	-0.9	0.1
Condit. Reinf. active responses	0.0	0.1	0.1	0.2	0.2	-0.3
Condit. Reinf. inactive responses	0.2	0.3	0.5	0.7	0.6	-0.0
Condit. Reinf. lever presses	2.8	3.8	5.0	1.8	1.8	-2.2
Condit. Reinf. lever reinforcers received	0.3	0.4	0.7	0.6	0.6	-0.8
Conditioned reinforcement - actives	0.3	0.3	0.3	-0.6	-0.5	-0.5
Conditioned reinforcement - inactives	5.5	6.2	9.1	-3.0	-2.7	1.5
Conditioned locomotion	8.2	9.9	13.6	-3.7	-3.3	2.2
Patch foraging indifference point 0 sec	0.0	0.0	0.1	-0.2	-0.1	0.2
Patch foraging indifference point AUC	4.4	5.0	6.3	2.0	2.2	-2.5
Delay disc. indifference point, 0s delay	0.8	0.9	1.6	-0.2	-1.0	1.3
Delay disc. indifference point, 16s delay	0.8	0.8	0.8	-0.9	-0.9	0.9
Delay disc. indifference point, 2s delay	0.1	0.1	0.1	-0.1	-0.4	0.4
Delay disc. indifference point, 24s delay	0.2	0.2	0.4	-0.2	-0.3	0.7
Delay disc. indifference point, 4s delay	0.5	0.5	1.2	-0.1	-0.5	1.1
Delay disc. indifference point, 8s delay	0.2	0.2	0.6	0.1	-0.3	0.8
Indifference point function ln k	10.8	15.0	18.5	-3.5	-3.7	4.3
Indifference point function log k	10.8	15.0	18.5	-3.5	-3.7	4.3
Patch foraging total patch changes 0 sec	0.0	0.0	0.1	-0.2	-0.0	0.3
Patch foraging total patch changes 12 sec	5.3	6.8	7.7	2.6	2.8	-2.5
Patch foraging total patch changes 18 sec	0.7	1.0	1.1	1.0	0.9	-1.0
Patch foraging total patch changes 24 sec	2.7	3.3	3.7	1.7	1.9	-1.9
Patch foraging total patch changes 6 sec	0.9	1.3	1.9	1.2	1.4	-0.7
Patch foraging time to switch 0 sec	2.2	3.4	4.7	2.2	1.8	-1.5
Patch foraging water rate 0 sec	4.4	7.1	9.9	-3.1	-2.6	2.1
Patch foraging water rate 12 sec	10.0	15.3	17.5	-4.2	-3.8	3.7
Patch foraging water rate 18 sec	4.1	5.5	6.6	-2.3	-2.2	2.6
Patch foraging water rate 24 sec	4.9	6.8	7.5	-2.7	-2.7	2.4
Patch foraging water rate 6 sec	5.1	7.5	8.1	-2.8	-2.5	2.8
Seeking ratio, delayed vs. immediate footshock	0.1	0.1	0.3	-0.1	0.0	0.6
Distance traveled before self-admin	1.0	1.1	1.7	0.9	0.8	-1.3
Distance traveled after self-admin	0.4	0.4	0.7	0.4	0.7	-0.9
Extensor digitorum longus weight	8.0	31.7	37.3	6.1	5.9	-4.8
Bone: elastic displacement	1.7	2.0	2.2	-1.5	-1.2	1.5
Bone: elastic work	0.3	0.4	0.7	0.7	0.9	-0.1
Bone: endosteal estimation	0.6	1.2	1.8	-0.7	-1.3	1.2
Bone: endosteal perimeter	0.6	1.2	2.3	-0.9	-1.5	0.8
Epididymis fat weight	2.5	5.8	7.4	-2.3	-2.7	2.1
Delta time in closed arm before/after self-admin	0.4	0.4	1.0	0.1	0.1	1.0
Delta time in open arm before/after self-admin	0.5	0.5	1.4	0.1	0.2	-1.2
Diff in mean of infusions in LGA sessions	0.5	0.5	0.8	0.5	0.8	-0.9
Delay discount exponential model param	0.1	0.1	0.3	-0.1	0.3	-0.6
Extinction: sum of active levers before priming	5.4	5.3	6.1	2.5	2.4	-2.1
Active lever presses in extinction session 6	3.6	3.5	5.7	1.5	1.6	-2.4
Bone: final force	3.5	5.6	6.2	2.5	2.4	-2.2
Bone: final moment	3.0	4.9	5.5	2.3	2.2	-2.1
Food consumed during 24 hour testing period	0.2	0.3	0.8	-0.1	0.2	-0.9
Glucose	1.9	2.8	3.4	-1.4	-1.8	1.8
Heart weight	4.2	6.0	7.0	-2.3	-2.4	2.6
Delay discount hyperbolic model param	0.1	0.1	0.3	-0.2	0.2	-0.5
Intermittent access intake day 1-15 change	0.7	0.7	1.3	-1.1	-0.8	-0.2
Intermittent access intake escalation	0.6	0.6	1.0	-1.0	-0.8	-0.0
Intermittent access intake escalation 2	0.3	0.3	0.5	-0.7	-0.4	-0.6
Intermitt. access day 1 inactive lever presses	2.3	2.5	3.1	-1.8	-1.6	1.3
Intermitt. access day 15 inactive lever presses	2.4	2.6	3.7	-1.9	-1.9	0.8
Intermitt. access escalation Index	4.6	4.1	5.9	-1.5	-2.0	2.4
Intermittent access day 1 total infusions	5.2	6.1	7.4	-2.1	-2.7	2.5
Intermittent access day 15 total infusions	7.7	8.7	11.1	-3.2	-3.3	2.2
Intermittent access terminal intake (last 3 days)	4.9	5.4	7.5	-2.4	-2.7	1.6
Intermittent access total infusions	4.3	4.8	6.6	-2.1	-2.6	1.8
Intermittent access day 1 locomotion	4.4	4.6	6.6	-1.6	-2.2	2.6
Intermittent access day 15 total locomotion	4.5	4.9	6.2	-2.4	-2.5	1.7
Intermittent access total locomotion	5.4	6.2	8.1	-2.4	-2.9	2.2
Intermittent access standard deviation	1.2	1.3	2.0	-1.4	-1.3	0.4
Left kidney weight	0.5	1.5	2.1	-1.3	-1.5	0.8
Right kidney weight	0.1	0.3	0.5	-0.7	-0.6	-0.5
Cocaine induced anxiety	0.1	0.1	0.3	0.0	-0.0	-0.5
Post-drug Anxiety	1.9	2.1	3.5	1.1	1.3	-1.9
Baseline Anxiety	2.4	2.5	3.2	1.5	1.8	-1.4
Tail length	0.5	1.5	1.8	1.0	1.2	-1.3
Length with tail	2.1	7.7	8.7	2.6	3.0	-2.8
Length without tail	2.5	5.5	7.0	2.2	2.6	-2.2
Times rat made contact with spout	0.3	0.3	0.5	0.7	0.7	-0.2
Lifetime Intake	3.9	4.4	5.7	-1.9	-2.4	2.0
Liver weight, left	0.0	0.0	0.1	-0.2	-0.2	0.2
Liver weight, right	0.1	0.2	0.5	-0.1	-0.3	0.7
Locomotor activity	2.5	3.9	4.5	-2.1	-1.7	2.1
Locomotor testing distance	3.7	6.1	7.5	-2.5	-2.2	2.7
Locomotor testing rearing	3.2	4.9	5.6	-2.1	-2.1	2.4
Locomotion in novel chamber	4.2	5.1	6.7	-2.6	-2.6	1.4
Locomotion in novel chamber post-restriction	3.0	3.6	4.2	-2.1	-2.0	1.6
Fecal boli incidents, locomotor time 1	0.4	0.5	1.4	0.2	0.2	-1.2
Change in fecal boli incidents, locomotor task	0.5	0.4	1.3	0.2	0.0	1.1
Time >=10cm from walls, locomotor time 1	0.3	0.3	0.6	-0.3	-0.8	0.3
Bouts of movement, locomotor time 1	1.8	1.9	2.8	1.0	1.4	-1.7
Total resting periods, locomotor time 1	1.4	1.5	2.4	0.9	1.2	-1.5
Rest time, locomotor task time 1	1.3	1.4	1.9	-1.4	-1.3	0.8
Distance moved, locomotor task time 1	0.1	0.1	0.3	0.5	0.3	0.1
Vertical activity count, locomotor time 1	1.5	1.6	1.7	-1.3	-1.2	1.3
Time >=10cm from walls, locomotor time 2	0.2	0.2	0.6	0.3	0.1	-0.8
Bouts of movement, locomotor time 2	0.5	0.6	0.7	0.6	0.9	-0.7
Total resting periods, locomotor time 2	0.2	0.3	0.4	0.4	0.6	-0.5
Rest time, locomotor task time 2	2.6	3.0	3.7	-1.6	-1.9	1.6
Distance moved, locomotor task time 2	1.2	1.4	1.5	1.1	1.2	-1.2
Vertical activity count, locomotor time 2	0.1	0.1	0.2	-0.5	0.0	0.3
Light reinforcement 1	0.2	0.3	0.4	-0.6	-0.5	0.4
Light reinforcement 2	0.7	0.9	1.6	-1.1	-1.2	-0.1
Bone: marrow area	0.6	1.4	2.0	-0.7	-1.4	1.3
Bone: maximum diameter	0.4	0.8	1.9	0.6	0.5	-1.4
Bone: maximum force	4.0	6.9	8.5	2.9	2.6	-2.4
Bone: maximum moment	3.4	5.9	7.3	2.7	2.3	-2.2
Mean time between licks in bursts	0.4	0.5	1.0	0.7	1.0	0.1
Mean num. licks in bursts	0.3	0.4	0.6	-0.5	-0.6	0.8
Cd content in liver	1.1	1.2	2.0	-1.4	-1.2	0.2
Co content in liver	2.0	2.4	3.0	-1.7	-1.3	1.6
Cu content in liver	0.2	0.3	0.4	0.6	0.5	-0.4
Fe content in liver	0.2	0.2	0.4	0.4	0.3	-0.6
K content in liver	1.7	1.7	2.9	1.7	1.3	-0.7
Mg content in liver	0.2	0.2	0.5	0.7	0.2	0.3
Mn content in liver	3.3	3.8	4.8	1.8	1.8	-2.2
Na content in liver	1.5	1.5	2.1	1.1	1.1	-1.4
Rb content in liver	1.8	2.2	2.9	-1.2	-1.5	1.7
Se content in liver	0.2	0.3	0.8	0.0	-0.1	-0.9
Sr content in liver	4.0	3.7	4.9	1.5	1.9	-2.2
Zn content in liver	1.3	1.4	1.6	1.3	1.2	-1.1
Bone: minimum diameter	0.6	1.1	1.5	-0.5	-1.2	1.2
Time in familiar zone, hab. session 1	0.3	0.2	0.4	-0.3	-0.5	0.6
Time in novel zone, hab. session 1	0.3	0.3	0.4	-0.6	-0.4	0.6
Total zone transitions, hab. session 1	0.6	0.9	1.1	1.0	1.0	-0.8
Total locomotion distance, hab. session 1	0.3	0.4	0.6	-0.3	-0.7	0.7
Locomotion velocity, hab. session 1	0.0	0.0	0.1	0.1	-0.2	0.3
Time in familiar zone, hab. session 2	0.2	0.2	0.5	-0.2	-0.0	0.7
Time in novel zone, hab. session 2	0.1	0.1	0.2	0.4	0.2	-0.4
Total zone transitions, hab. session 2	1.4	1.8	3.4	1.8	1.3	-0.6
Total locomotion distance, hab. session 2	0.2	0.3	0.6	0.5	-0.1	0.8
Locomotion velocity, hab. session 2	0.2	0.2	0.6	0.3	-0.3	0.7
Novel to familiar place preference ratio	1.9	2.0	3.2	1.2	1.1	-1.8
Novelty place preference	1.0	1.0	1.9	0.8	0.7	-1.4
Time in novel zone, NPP test	0.7	0.7	1.3	0.7	0.6	-1.1
Total zone transitions, NPP test	2.5	3.6	4.7	2.2	1.9	-1.5
Total locomotion distance, NPP test	0.1	0.1	0.3	0.6	0.2	0.3
Locomotion velocity, NPP test	0.1	0.1	0.3	0.6	0.3	0.1
Intraocular pressure	0.8	1.1	2.0	-1.4	-1.1	-0.3
Delta distance traveled before/after self-admin	0.1	0.1	0.3	-0.3	0.0	0.5
Delta ambulatory time before/after self-admin	0.1	0.1	0.3	-0.2	0.1	0.5
Parametrial fat weight	1.9	3.6	4.3	-1.6	-2.1	2.0
Pavlov. Cond. lever latency	0.3	0.4	0.7	-0.8	-0.6	0.5
Pavlov. Cond. magazine entry latency	0.3	0.4	0.7	0.8	0.5	-0.4
Pavlov. Cond. change in total contacts	0.2	0.2	0.5	0.4	0.2	-0.7
Pavlov. Cond. index score	0.2	0.3	0.4	0.5	0.4	-0.6
Pavlov. Cond. latency score	0.1	0.1	0.2	0.5	0.3	-0.3
Pavlov. Cond. lever contacts	0.0	0.0	0.1	0.3	0.1	0.1
Pavlov. Cond. magazine entry number	0.5	0.6	1.2	-0.5	-0.6	1.1
Pavlov. Cond. intertrial magazine entries	0.5	0.6	1.2	-1.1	-0.8	0.3
Pavlov. Cond. lever-magazine prob. diff.	0.5	0.6	0.7	0.8	0.7	-0.8
Pavlov. Cond. response bias	0.2	0.2	0.4	0.3	0.3	-0.6
Pavlov. Cond. lever latency	0.7	1.0	1.5	-0.9	-0.8	1.2
Pavlov. Cond. magazine entry latency	3.9	4.5	5.2	2.3	2.1	-2.0
Pavlov. Cond. change in total contacts	2.8	3.8	5.8	1.7	1.6	-2.4
Pavlov. Cond. index score	3.1	4.0	4.8	2.0	1.8	-2.2
Pavlov. Cond. latency score	2.6	3.2	3.8	1.8	1.6	-2.0
Pavlov. Cond. lever contacts	0.8	1.1	1.9	0.7	0.9	-1.4
Pavlov. Cond. magazine entry number	7.5	9.2	9.5	-3.0	-3.0	3.1
Pavlov. Cond. intertrial magazine entries	1.2	1.5	1.8	-1.3	-1.4	1.1
Pavlov. Cond. lever-magazine prob. diff.	3.7	4.7	5.4	2.2	2.0	-2.3
Pavlov. Cond. response bias	2.4	3.3	4.4	1.6	1.7	-2.1
Time in closed arm before self-admin	0.2	0.2	0.5	0.3	0.1	-0.7
Time in closed arm after self-admin	0.2	0.2	0.6	-0.1	-0.1	0.8
Time in open arm before self-admin	1.5	1.7	3.7	-0.8	-0.8	1.9
Time in open arm after self-admin	0.2	0.2	0.4	-0.6	-0.5	0.2
Bone: periosteal estimation	0.0	0.1	0.1	0.3	-0.2	-0.3
Bone: periosteal perimeter	0.2	0.3	0.6	0.5	0.3	-0.7
Bone: post-yield work	0.9	1.3	2.5	1.6	0.7	-0.9
Progressive ratio test 1 active lever presses	3.1	3.3	4.0	-2.0	-2.0	1.4
Progressive ratio test 1 breakpoint	2.8	2.9	3.6	-1.9	-1.9	1.3
Progressive ratio test 1 inactive lever presses	1.6	1.7	1.8	-1.3	-1.3	1.3
Progressive ratio test 2 active lever presses	4.2	4.5	6.0	-2.4	-2.4	1.4
Progressive ratio test 2 breakpoint	5.6	6.3	8.1	-2.8	-2.8	1.7
Progressive ratio test 2 inactive lever presses	8.3	9.6	12.1	-3.4	-3.5	2.3
Incentive Sensitization - Responses	0.4	0.4	0.6	-0.7	-0.8	0.2
Incentive Sensitization - Breakpoint	0.6	0.6	1.0	-0.9	-1.0	0.3
Sum of active levers in priming session hrs 5-6	3.3	3.2	6.9	0.9	1.4	-2.6
Progressive ratio	2.7	3.1	5.0	2.2	1.6	-1.3
Food seeking constrained by brief footshock	0.1	0.1	0.3	0.3	0.5	0.2
Seeking ratio, punishment vs. effort	2.7	3.2	4.2	-2.0	-1.5	1.8
Retroperitoneal fat weight	5.4	17.7	19.7	-4.2	-4.4	4.0
Reaction time number correct	0.2	0.3	0.5	0.5	0.5	-0.7
Reaction time mean minus median	4.3	5.7	7.2	2.2	2.2	-2.7
Reaction time mean minus median AUC	2.2	2.9	4.1	1.5	1.5	-2.0
Reaction time num false alarms	0.8	1.0	2.4	-0.7	-0.5	1.5
Reaction time num false alarms AUC	0.2	0.3	0.9	-0.0	0.2	0.9
Reaction time trials correct on left	0.2	0.3	0.5	0.5	0.5	-0.7
Reaction time trials on left	0.3	0.5	0.6	0.6	0.6	-0.8
Reaction time mean	0.2	0.3	0.8	0.2	0.3	-0.9
Reaction time mean AUC	0.2	0.2	0.7	0.2	0.2	-0.8
Median of all reaction times	0.0	0.1	0.1	-0.2	-0.2	-0.3
Reaction time omissions	1.3	1.8	1.9	1.3	1.4	-1.4
Reaction time false alarm rate	0.6	0.8	2.0	-0.5	-0.4	1.4
Reaction time premature initiation rate	1.9	2.5	3.5	1.8	1.9	-0.9
Reaction time premature initiations	3.1	4.4	5.7	2.2	2.4	-1.6
Std. dev. reaction times	1.3	1.8	3.0	1.1	1.2	-1.7
Reaction time trials completed	0.3	0.5	0.6	0.6	0.6	-0.8
Reaction time trials AUC	0.1	0.2	0.2	0.4	0.4	-0.5
Run reversals in cocaine runway, females	0.7	0.7	1.1	1.1	0.6	0.8
Run reversals in cocaine runway, males	0.4	0.3	0.7	-0.9	-0.5	0.2
Latency to leave start box in cocaine runway	0.0	0.0	0.1	0.1	-0.1	0.3
Latency to leave start box in cocaine runway, F	0.0	0.0	0.0	0.2	0.0	-0.0
Latency to leave start box in cocaine runway, M	0.0	0.0	0.1	0.0	0.0	0.3
Std. dev. time between licks in bursts	0.3	0.4	1.0	-0.4	-0.1	1.0
Total sessions with >9 infusions	2.1	2.4	3.6	-1.2	-1.4	1.9
Short access day 1 total inactive lever presses	4.4	4.9	5.1	-2.2	-2.2	2.3
Short access day 10 total inactive lever presses	4.8	5.3	6.4	-2.2	-2.1	2.5
Short access day 1 total infusions	3.1	3.3	4.4	-1.4	-1.8	2.1
Short access day 10 total infusions	1.5	1.7	2.7	-0.8	-1.4	1.7
Short access total infusions	1.6	1.8	2.8	-0.9	-1.3	1.7
Short access day 1 locomotion	2.9	3.1	4.4	-1.3	-1.7	2.1
Short access day 10 total locomotion	2.0	2.2	3.1	-1.1	-1.5	1.8
Short access total locomotion	1.8	1.9	3.1	-0.9	-1.3	1.8
One hour access (0.3 mA shock)	10.5	12.3	15.1	-3.8	-3.9	2.7
Compulsive drug intake	1.9	1.9	3.0	1.5	1.7	-0.8
One hour access (shock baseline)	8.3	9.6	13.0	-3.5	-3.6	1.9
Social response proportion	1.3	1.4	1.6	1.1	1.3	-1.3
Social responses	0.2	0.3	0.4	0.4	0.6	-0.6
Social time	0.3	0.3	0.4	0.6	0.5	-0.6
Soleus weight	4.3	12.6	13.8	-3.6	-3.7	3.4
Bone: stiffness	3.5	5.5	6.3	2.5	2.2	-2.3
Tibialis anterior weight	11.7	40.0	42.7	6.3	6.5	-6.1
Time to tail flick, vehicle, before self-admin	0.6	0.6	1.0	1.0	0.5	-0.7
Time to tail flick, vehicle, after self-admin	1.2	1.3	2.8	1.7	1.0	-0.3
Time to tail flick, test, before self-admin	1.3	1.3	2.6	-0.4	-1.0	1.6
Time to tail flick, test, after self-admin	0.0	0.0	0.0	0.1	0.1	-0.2
Delta time to tail flick, vehicle, before/after SA	0.4	0.4	0.7	0.8	0.6	-0.0
Delta time to tail flick, test, before/after SA	2.0	1.8	3.7	0.6	1.2	-1.9
Tibia length	1.8	5.2	9.7	1.6	1.8	-3.1
Ambulatory time before self-admin	1.0	1.0	2.0	0.7	0.7	-1.4
Ambulatory time after self-admin	0.0	0.0	0.1	-0.2	-0.0	-0.3
Bone: tissue strength	0.1	0.1	0.2	0.1	0.2	-0.4
Total heroin consumption	6.4	7.5	8.2	2.8	2.9	-2.6
Bone: trabecular number	0.6	0.9	1.2	1.1	0.8	-1.0
Bone: trabecular spacing	0.4	0.6	1.0	-0.6	-0.5	1.0
Bone: trabecular thickness	0.4	0.5	0.7	-0.6	-0.8	0.7
Bone: trabecular tissue density	3.4	4.8	6.0	-2.5	-2.3	1.7
Water consumed over 24 hours	0.7	0.8	0.9	0.8	1.0	-0.9
Number of responses in last shaping day	1.8	1.9	2.0	-1.4	-1.4	1.3