Hub : Genes

Zfpl1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	gene expression	Zfpl1	0.04	0.02	1.7e-03	0.02	0.01	0.01	0.01	5.0e-03	1.1e-02	4.4e-02	1.0e-02
2	Liver	alternative TSS	NM_001286936.1	0.03	0.02	4.2e-03	0.01	0.01	0.01	0.01	1.3e-02	2.0e-02	4.3e-02	3.9e-02
3	Liver	gene expression	Zfpl1	0.07	0.04	9.0e-06	0.02	0.04	0.04	0.03	4.9e-03	2.5e-05	6.0e-05	5.5e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bone: apparent density	0.3	0.5	0.8	0.9	-0.7	-0.5
Area under the delay curve	0.1	0.1	0.4	-0.1	0.1	0.6
BMI with tail	1.2	4.1	5.6	2.4	-2.4	-1.1
BMI without tail	0.3	1.6	2.4	1.5	-1.6	-0.2
Body weight	2.6	11.4	14.1	3.8	-3.7	-2.5
Weight adjusted by age	0.9	2.5	2.8	1.5	-1.6	-1.7
Bone surface	4.8	9.5	9.9	3.1	-3.0	-3.1
Bone volume	1.7	3.3	4.0	1.8	-1.6	-2.0
Breakpoint value in progressive ratio session	2.3	4.1	4.4	2.0	-1.9	-2.1
Number of licking bursts	0.2	0.5	0.6	0.6	-0.7	-0.8
Context. condit. distance diff. score	2.5	3.0	3.3	-1.6	1.7	1.8
Locomotion velocity, session 1	0.1	0.1	0.1	0.2	-0.1	0.4
Locomotion distance, session 1	0.3	0.4	0.6	0.8	-0.8	0.1
Locomotion velocity, session 2	2.5	2.9	3.7	1.9	-1.9	-1.2
Locomotion distance, session 2	0.5	0.7	1.2	1.0	-1.1	-0.1
Locomotion velocity, session 3	0.5	0.5	1.1	-0.5	0.5	1.0
Locomotion distance, session 3	0.1	0.1	0.1	-0.2	0.2	0.3
Stereotopy head waving bouts, day 3	1.0	1.2	2.4	-0.8	0.8	1.5
Stereotopy head waving duration, day 3	0.7	0.9	1.2	-0.8	0.9	1.1
Locomotion velocity, session 7	0.6	0.6	1.1	-0.7	0.6	1.1
Locomotion distance, session 7	0.3	0.3	0.9	-0.2	0.1	1.0
Stereotopy head waving bouts, day 7	0.0	0.0	0.1	-0.1	0.1	-0.3
Stereotopy head waving duration, day 7	0.9	1.1	1.3	1.0	-0.9	-1.2
Locomotion velocity, session 8	0.7	0.8	1.2	1.1	-1.0	-0.5
Locomotion distance, session 8	0.3	0.5	0.9	-0.5	0.6	0.9
Degree of sensitization distance	0.1	0.1	0.3	-0.0	-0.0	0.6
Degree of sensitization stereotypy	0.7	0.8	1.4	0.7	-0.7	-1.2
Conditioned locomotion	1.6	1.9	2.4	1.4	-1.5	-1.1
Cocaine response after cond. corrected	1.6	2.4	3.5	-1.4	1.4	1.9
Cocaine response after cond. not corrected	1.2	1.8	2.5	-1.2	1.2	1.6
Cocaine response before conditioning	1.0	1.2	1.9	1.0	-0.9	-1.4
Saline control response	3.9	5.4	6.6	2.5	-2.6	-1.8
Bone: connectivity density	2.1	3.3	4.1	2.0	-1.8	-1.6
Bone: cortical apparent density	0.1	0.1	0.1	0.3	-0.3	-0.3
Bone: cortical area	0.9	1.4	1.8	1.2	-1.0	-1.3
Bone: cortical porosity	0.2	0.2	0.3	0.5	-0.5	-0.3
Bone: cortical porosity	0.6	0.7	0.8	0.9	-0.9	-0.6
Bone: cortical thickness	2.7	4.4	5.3	2.3	-2.1	-1.9
Bone: cortical thickness	0.2	0.3	0.5	0.7	-0.6	-0.0
Bone: cortical tissue density	0.1	0.2	0.2	0.5	-0.5	-0.5
Condit. Reinf. active minus inactive responses	0.1	0.1	0.2	0.4	-0.4	-0.1
Condit. Reinf. active-inactive response ratio	0.0	0.0	0.1	0.2	-0.1	-0.1
Condit. Reinf. active responses	0.0	0.0	0.0	0.1	-0.1	0.1
Condit. Reinf. inactive responses	0.1	0.1	0.2	-0.4	0.3	0.3
Incentive salience index mean	0.2	0.2	0.3	0.6	-0.6	-0.1
Condit. Reinf. lever presses	0.3	0.5	0.5	0.7	-0.7	-0.7
Condit. Reinf. active minus inactive responses	0.1	0.1	0.1	-0.3	0.3	-0.3
Condit. Reinf. active-inactive response ratio	0.3	0.6	0.9	-0.9	0.9	0.1
Condit. Reinf. active responses	0.1	0.2	0.4	0.3	-0.4	-0.6
Condit. Reinf. inactive responses	0.4	0.6	0.8	0.9	-0.9	-0.3
Condit. Reinf. lever presses	2.3	3.4	4.7	1.6	-1.7	-2.2
Condit. Reinf. lever reinforcers received	0.5	0.7	1.0	0.6	-0.7	-1.0
Conditioned reinforcement - actives	0.2	0.7	1.9	0.1	-0.2	-1.4
Conditioned reinforcement - inactives	1.1	3.1	4.9	-2.0	2.2	0.6
Conditioned locomotion	5.8	8.7	11.1	-3.3	3.3	2.0
Patch foraging indifference point 0 sec	0.0	0.0	0.1	0.0	0.3	0.2
Patch foraging indifference point AUC	1.7	4.0	5.7	1.8	-1.7	-2.4
Delay disc. indifference point, 0s delay	0.5	0.6	1.4	-0.4	0.4	1.2
Delay disc. indifference point, 16s delay	0.6	0.8	1.0	-0.9	1.0	0.7
Delay disc. indifference point, 2s delay	0.1	0.1	0.2	-0.3	0.4	0.4
Delay disc. indifference point, 24s delay	0.1	0.1	0.3	-0.2	0.1	0.5
Delay disc. indifference point, 4s delay	0.4	0.4	1.1	-0.2	0.3	1.1
Delay disc. indifference point, 8s delay	0.1	0.2	0.6	-0.0	0.1	0.8
Indifference point function ln k	4.7	14.1	17.6	-3.5	3.5	4.2
Indifference point function log k	4.7	14.1	17.6	-3.5	3.5	4.2
Patch foraging total patch changes 0 sec	0.0	0.0	0.0	0.1	0.2	0.2
Patch foraging total patch changes 12 sec	4.6	6.1	6.6	2.6	-2.5	-2.3
Patch foraging total patch changes 18 sec	0.4	0.8	1.1	0.9	-0.8	-1.0
Patch foraging total patch changes 24 sec	0.9	3.1	3.4	1.8	-1.6	-1.8
Patch foraging total patch changes 6 sec	0.7	1.1	1.8	1.3	-1.1	-0.7
Patch foraging time to switch 0 sec	0.7	2.6	2.9	1.6	-1.7	-1.4
Patch foraging water rate 0 sec	1.7	6.4	7.9	-2.8	2.6	2.1
Patch foraging water rate 12 sec	3.5	14.1	14.4	-3.8	3.7	3.7
Patch foraging water rate 18 sec	2.2	4.9	6.3	-2.1	2.0	2.5
Patch foraging water rate 24 sec	4.2	6.0	6.6	-2.6	2.4	2.4
Patch foraging water rate 6 sec	5.3	7.8	8.6	-2.9	2.6	2.9
Seeking ratio, delayed vs. immediate footshock	0.2	0.3	0.5	-0.5	0.2	0.7
Distance traveled before self-admin	0.5	1.2	1.7	1.0	-0.9	-1.3
Distance traveled after self-admin	0.2	0.4	0.7	0.6	-0.4	-0.8
Extensor digitorum longus weight	7.7	30.6	35.2	5.9	-5.9	-4.7
Bone: elastic displacement	1.0	1.3	1.7	-1.0	1.0	1.3
Bone: elastic work	0.6	0.7	1.2	1.1	-1.0	-0.2
Bone: endosteal estimation	0.6	1.4	1.4	-1.2	1.2	1.2
Bone: endosteal perimeter	0.6	1.5	1.9	-1.4	1.4	0.8
Epididymis fat weight	1.8	9.2	12.0	-3.5	3.3	2.2
Delta time in closed arm before/after self-admin	0.3	0.3	0.6	0.4	-0.3	0.8
Delta time in open arm before/after self-admin	0.7	0.8	2.1	0.5	-0.4	-1.5
Diff in mean of infusions in LGA sessions	0.3	0.6	0.6	0.8	-0.8	-0.8
Delay discount exponential model param	0.1	0.1	0.3	-0.0	-0.0	-0.5
Extinction: sum of active levers before priming	1.7	2.6	3.1	1.8	-1.6	-1.4
Active lever presses in extinction session 6	4.6	4.7	5.9	2.0	-2.0	-2.4
Bone: final force	2.7	4.4	5.0	2.2	-2.1	-2.0
Bone: final moment	2.5	4.0	4.6	2.2	-2.0	-1.9
Food consumed during 24 hour testing period	0.2	0.3	0.8	0.2	-0.3	-0.9
Glucose	3.0	4.8	5.8	-2.1	2.0	2.4
Heart weight	1.8	2.9	5.8	-1.2	1.2	2.4
Delay discount hyperbolic model param	0.1	0.1	0.2	-0.0	-0.1	-0.5
Intermittent access intake day 1-15 change	0.2	1.3	2.0	-1.4	1.4	0.2
Intermittent access intake escalation	0.2	1.0	1.6	-1.2	1.3	-0.1
Intermittent access intake escalation 2	0.5	0.9	1.4	-1.1	1.2	-0.1
Intermitt. access day 1 inactive lever presses	0.0	0.2	0.4	-0.4	0.6	0.1
Intermitt. access day 15 inactive lever presses	0.4	2.0	3.0	-1.6	1.7	0.6
Intermitt. access escalation Index	1.4	4.4	4.9	-2.0	2.1	2.2
Intermittent access day 1 total infusions	1.0	3.1	3.5	-1.9	1.8	1.5
Intermittent access day 15 total infusions	2.4	5.9	7.9	-2.8	2.8	1.3
Intermittent access terminal intake (last 3 days)	2.6	4.5	6.3	-2.5	2.5	1.1
Intermittent access total infusions	3.1	3.7	4.8	-2.2	2.1	1.3
Intermittent access day 1 locomotion	1.3	2.5	2.9	-1.7	1.7	1.3
Intermittent access day 15 total locomotion	1.2	4.5	6.6	-2.5	2.6	0.9
Intermittent access total locomotion	5.4	6.5	8.8	-2.9	3.0	1.4
Intermittent access standard deviation	0.3	1.6	2.4	-1.4	1.5	0.6
Left kidney weight	0.3	2.4	2.8	-1.6	1.7	1.3
Right kidney weight	0.1	1.0	1.3	-1.1	1.1	0.7
Cocaine induced anxiety	0.1	0.1	0.4	0.2	-0.1	-0.6
Post-drug Anxiety	0.8	0.9	1.2	0.9	-0.9	-1.1
Baseline Anxiety	0.2	0.3	0.4	0.6	-0.7	-0.1
Tail length	0.3	1.7	2.1	1.4	-1.4	-0.9
Length with tail	1.9	8.2	9.9	3.1	-3.1	-2.3
Length without tail	1.2	6.2	7.5	2.7	-2.7	-1.9
Times rat made contact with spout	0.4	0.4	0.6	0.8	-0.8	-0.3
Lifetime Intake	2.3	2.9	3.6	-1.9	1.8	1.3
Liver weight, left	1.0	1.7	2.0	-1.2	1.2	1.4
Liver weight, right	2.9	5.0	6.9	-2.0	2.1	2.6
Locomotor activity	2.6	4.0	4.7	-2.0	1.8	2.2
Locomotor testing distance	2.1	5.2	6.7	-2.2	2.0	2.6
Locomotor testing rearing	1.2	4.5	6.0	-1.9	2.0	2.4
Locomotion in novel chamber	4.4	5.9	7.0	-2.6	2.6	1.9
Locomotion in novel chamber post-restriction	1.3	3.9	4.9	-2.2	2.2	1.4
Fecal boli incidents, locomotor time 1	0.1	0.4	1.1	0.2	0.1	-1.0
Change in fecal boli incidents, locomotor task	0.3	0.4	1.0	-0.1	-0.1	1.0
Time >=10cm from walls, locomotor time 1	0.3	0.4	0.7	-0.7	0.9	0.2
Bouts of movement, locomotor time 1	2.0	2.6	3.3	1.4	-1.6	-1.8
Total resting periods, locomotor time 1	1.6	1.8	2.7	1.1	-1.2	-1.6
Rest time, locomotor task time 1	0.8	1.3	1.9	-1.4	1.2	0.7
Distance moved, locomotor task time 1	0.0	0.1	0.1	0.3	-0.2	0.1
Vertical activity count, locomotor time 1	0.2	1.4	1.5	-1.2	1.2	1.2
Time >=10cm from walls, locomotor time 2	0.1	0.4	0.9	0.4	-0.3	-1.0
Bouts of movement, locomotor time 2	0.2	0.6	0.7	0.7	-0.8	-0.8
Total resting periods, locomotor time 2	0.1	0.2	0.3	0.4	-0.5	-0.5
Rest time, locomotor task time 2	1.6	2.7	3.1	-1.7	1.6	1.5
Distance moved, locomotor task time 2	1.2	1.6	1.7	1.3	-1.3	-1.2
Vertical activity count, locomotor time 2	0.0	0.0	0.1	-0.1	0.0	0.2
Light reinforcement 1	0.0	0.1	0.1	-0.2	0.4	0.2
Light reinforcement 2	0.3	0.6	1.0	-0.9	1.0	-0.1
Bone: marrow area	0.7	1.6	1.8	-1.3	1.2	1.3
Bone: maximum diameter	0.4	0.8	1.6	0.6	-0.5	-1.3
Bone: maximum force	3.1	6.2	6.7	2.6	-2.5	-2.4
Bone: maximum moment	2.9	5.5	6.2	2.5	-2.4	-2.2
Mean time between licks in bursts	0.0	0.2	0.3	0.5	-0.6	0.4
Mean num. licks in bursts	0.1	0.4	0.7	-0.5	0.5	0.8
Cd content in liver	0.9	1.0	1.5	-1.2	1.2	0.2
Co content in liver	1.4	1.7	2.0	-1.2	1.2	1.4
Cu content in liver	0.0	0.0	0.0	-0.1	0.2	0.2
Fe content in liver	0.1	0.1	0.2	0.4	-0.4	-0.3
K content in liver	0.2	0.2	0.4	0.6	-0.5	0.0
Mg content in liver	0.7	0.8	1.4	-0.7	0.7	1.2
Mn content in liver	4.1	4.5	5.2	2.0	-2.1	-2.3
Na content in liver	0.5	0.5	0.7	0.8	-0.6	-0.8
Rb content in liver	2.9	3.4	4.2	-1.7	1.8	2.0
Se content in liver	0.1	0.1	0.2	-0.4	0.3	-0.3
Sr content in liver	3.7	3.2	3.7	1.7	-1.7	-1.9
Zn content in liver	0.2	0.3	0.5	0.7	-0.5	-0.3
Bone: minimum diameter	0.6	1.2	1.3	-1.0	1.1	1.2
Time in familiar zone, hab. session 1	0.3	0.3	0.4	-0.5	0.5	0.6
Time in novel zone, hab. session 1	0.2	0.2	0.4	-0.4	0.3	0.6
Total zone transitions, hab. session 1	0.6	0.9	1.0	1.0	-1.0	-0.8
Total locomotion distance, hab. session 1	0.3	0.4	0.5	-0.5	0.6	0.7
Locomotion velocity, hab. session 1	0.0	0.0	0.1	-0.1	0.1	0.2
Time in familiar zone, hab. session 2	0.2	0.2	0.5	-0.1	0.2	0.7
Time in novel zone, hab. session 2	0.1	0.1	0.2	0.3	-0.4	-0.4
Total zone transitions, hab. session 2	1.2	1.5	2.2	1.4	-1.5	-0.5
Total locomotion distance, hab. session 2	0.2	0.2	0.6	0.0	-0.1	0.8
Locomotion velocity, hab. session 2	0.2	0.2	0.6	-0.2	0.2	0.8
Novel to familiar place preference ratio	1.5	2.0	3.2	1.2	-1.1	-1.8
Novelty place preference	0.8	1.0	1.9	0.8	-0.7	-1.4
Time in novel zone, NPP test	0.6	0.7	1.3	0.6	-0.6	-1.2
Total zone transitions, NPP test	2.3	3.4	4.2	2.0	-2.0	-1.5
Total locomotion distance, NPP test	0.1	0.1	0.1	0.3	-0.3	0.3
Locomotion velocity, NPP test	0.1	0.1	0.1	0.3	-0.4	0.1
Intraocular pressure	0.7	1.1	1.7	-1.3	1.3	-0.2
Delta distance traveled before/after self-admin	0.3	0.4	0.6	-0.5	0.5	0.8
Delta ambulatory time before/after self-admin	0.1	0.2	0.4	-0.2	0.2	0.6
Parametrial fat weight	3.4	7.9	9.3	-3.0	3.0	2.4
Pavlov. Cond. lever latency	0.2	0.3	0.4	-0.5	0.6	0.4
Pavlov. Cond. magazine entry latency	0.3	0.4	0.6	0.6	-0.8	-0.5
Pavlov. Cond. change in total contacts	0.3	0.3	0.7	0.3	-0.4	-0.8
Pavlov. Cond. index score	0.3	0.4	0.5	0.5	-0.7	-0.7
Pavlov. Cond. latency score	0.2	0.2	0.3	0.4	-0.6	-0.4
Pavlov. Cond. lever contacts	0.1	0.1	0.1	0.2	-0.4	-0.0
Pavlov. Cond. magazine entry number	0.6	0.8	1.2	-0.7	0.8	1.1
Pavlov. Cond. intertrial magazine entries	0.5	0.6	1.0	-0.9	1.0	0.3
Pavlov. Cond. lever-magazine prob. diff.	0.6	0.7	0.8	0.7	-0.9	-0.9
Pavlov. Cond. response bias	0.4	0.5	0.7	0.5	-0.6	-0.8
Pavlov. Cond. lever latency	0.9	1.2	2.1	-0.9	0.9	1.4
Pavlov. Cond. magazine entry latency	4.1	5.8	6.3	2.5	-2.4	-2.3
Pavlov. Cond. change in total contacts	1.4	3.5	5.6	1.6	-1.6	-2.4
Pavlov. Cond. index score	2.7	4.2	5.3	2.0	-1.9	-2.3
Pavlov. Cond. latency score	2.2	3.5	4.6	1.8	-1.7	-2.1
Pavlov. Cond. lever contacts	0.9	1.3	2.1	0.9	-0.9	-1.5
Pavlov. Cond. magazine entry number	8.1	10.6	11.1	-3.2	3.2	3.3
Pavlov. Cond. intertrial magazine entries	0.7	1.5	1.8	-1.3	1.3	1.0
Pavlov. Cond. lever-magazine prob. diff.	3.3	5.0	6.1	2.1	-2.1	-2.5
Pavlov. Cond. response bias	2.6	3.7	4.5	1.8	-1.8	-2.1
Time in closed arm before self-admin	0.1	0.2	0.3	-0.6	0.5	-0.1
Time in closed arm after self-admin	0.6	0.6	1.0	-0.6	0.7	1.0
Time in open arm before self-admin	1.0	1.2	3.2	-0.4	0.4	1.8
Time in open arm after self-admin	0.1	0.1	0.1	0.3	-0.4	-0.1
Bone: periosteal estimation	0.0	0.0	0.1	0.1	0.0	-0.3
Bone: periosteal perimeter	0.1	0.3	0.4	0.5	-0.4	-0.6
Bone: post-yield work	0.4	0.7	0.8	0.8	-0.9	-0.9
Progressive ratio test 1 active lever presses	0.1	0.2	0.4	-0.6	0.5	-0.0
Progressive ratio test 1 breakpoint	0.1	0.2	0.3	-0.5	0.4	-0.1
Progressive ratio test 1 inactive lever presses	0.0	0.1	0.2	-0.3	0.4	-0.2
Progressive ratio test 2 active lever presses	1.6	2.2	3.2	-1.8	1.8	0.6
Progressive ratio test 2 breakpoint	1.7	2.2	3.2	-1.8	1.7	0.5
Progressive ratio test 2 inactive lever presses	2.7	8.5	11.2	-3.3	3.4	1.8
Incentive Sensitization - Responses	0.0	0.0	0.1	-0.2	0.1	-0.2
Incentive Sensitization - Breakpoint	0.0	0.1	0.1	-0.4	0.3	-0.1
Sum of active levers in priming session hrs 5-6	3.2	3.0	6.8	1.1	-1.0	-2.6
Progressive ratio	0.5	1.4	2.2	1.2	-1.5	-0.8
Food seeking constrained by brief footshock	0.0	0.0	0.0	0.2	-0.2	0.2
Seeking ratio, punishment vs. effort	1.2	2.6	2.9	-1.5	1.7	1.7
Retroperitoneal fat weight	9.6	42.9	45.6	-6.7	6.7	6.2
Reaction time number correct	0.1	0.4	0.4	0.6	-0.6	-0.6
Reaction time mean minus median	1.0	6.6	7.7	2.4	-2.5	-2.8
Reaction time mean minus median AUC	0.5	3.5	4.3	1.7	-1.8	-2.1
Reaction time num false alarms	0.8	1.4	2.7	-0.8	0.9	1.7
Reaction time num false alarms AUC	0.2	0.4	1.2	-0.1	0.2	1.1
Reaction time trials correct on left	0.1	0.4	0.4	0.6	-0.6	-0.6
Reaction time trials on left	0.2	0.5	0.6	0.7	-0.7	-0.7
Reaction time mean	0.1	0.3	0.8	0.3	-0.3	-0.9
Reaction time mean AUC	0.1	0.2	0.7	0.2	-0.2	-0.8
Median of all reaction times	0.1	0.1	0.1	-0.4	0.4	-0.2
Reaction time omissions	1.9	3.0	3.2	1.6	-1.8	-1.8
Reaction time false alarm rate	0.8	1.1	2.3	-0.7	0.8	1.5
Reaction time premature initiation rate	1.9	2.9	4.2	2.0	-2.0	-0.8
Reaction time premature initiations	1.6	5.0	6.6	2.5	-2.6	-1.5
Std. dev. reaction times	0.7	2.2	3.2	1.3	-1.3	-1.8
Reaction time trials completed	0.2	0.5	0.6	0.7	-0.7	-0.7
Reaction time trials AUC	0.1	0.2	0.3	0.5	-0.5	-0.5
Run reversals in cocaine runway, females	0.4	0.4	0.7	0.5	-0.5	0.9
Run reversals in cocaine runway, males	0.3	0.3	0.5	-0.6	0.7	0.3
Latency to leave start box in cocaine runway	0.1	0.1	0.2	-0.4	0.3	0.4
Latency to leave start box in cocaine runway, F	0.0	0.0	0.1	-0.1	0.1	0.2
Latency to leave start box in cocaine runway, M	0.0	0.0	0.0	-0.1	0.1	0.2
Std. dev. time between licks in bursts	0.2	0.3	0.9	-0.2	0.1	1.0
Total sessions with >9 infusions	0.0	0.0	0.0	-0.1	-0.0	0.2
Short access day 1 total inactive lever presses	1.9	3.7	3.9	-2.0	2.0	1.8
Short access day 10 total inactive lever presses	0.2	1.2	1.5	-0.9	1.1	1.2
Short access day 1 total infusions	1.1	2.1	2.2	-1.5	1.4	1.5
Short access day 10 total infusions	0.3	0.6	0.6	-0.8	0.7	0.7
Short access total infusions	0.5	0.7	0.9	-0.8	0.7	1.0
Short access day 1 locomotion	1.3	2.1	2.6	-1.5	1.6	1.3
Short access day 10 total locomotion	0.3	1.1	1.5	-1.2	1.2	0.7
Short access total locomotion	1.1	1.6	2.0	-1.4	1.4	1.0
One hour access (0.3 mA shock)	6.4	7.6	9.3	-3.0	3.0	2.1
Compulsive drug intake	1.0	1.5	2.3	1.5	-1.5	-0.3
One hour access (shock baseline)	3.0	7.9	10.5	-3.2	3.2	1.7
Social response proportion	0.8	1.0	1.3	1.0	-0.8	-1.2
Social responses	0.2	0.3	0.4	0.6	-0.5	-0.6
Social time	0.3	0.4	0.5	0.7	-0.7	-0.6
Soleus weight	4.4	13.1	14.2	-3.7	3.8	3.4
Bone: stiffness	2.6	4.7	5.0	2.2	-2.1	-2.2
Tibialis anterior weight	11.1	38.2	40.4	6.4	-6.3	-5.9
Time to tail flick, vehicle, before self-admin	0.2	0.3	0.3	0.6	-0.6	-0.4
Time to tail flick, vehicle, after self-admin	0.2	0.4	0.7	0.8	-0.8	0.1
Time to tail flick, test, before self-admin	2.7	3.1	4.4	-1.6	1.5	2.1
Time to tail flick, test, after self-admin	0.2	0.2	0.5	0.2	-0.3	-0.7
Delta time to tail flick, vehicle, before/after SA	0.2	0.2	0.3	0.5	-0.5	0.1
Delta time to tail flick, test, before/after SA	2.9	3.6	6.3	1.5	-1.5	-2.5
Tibia length	1.8	4.9	9.2	1.7	-1.6	-3.0
Ambulatory time before self-admin	0.3	0.9	1.7	0.8	-0.7	-1.3
Ambulatory time after self-admin	0.1	0.2	0.3	-0.4	0.6	-0.0
Bone: tissue strength	0.0	0.0	0.0	-0.0	-0.1	-0.2
Total heroin consumption	5.8	6.8	7.0	2.6	-2.6	-2.6
Bone: trabecular number	0.6	1.2	1.4	1.1	-1.0	-1.2
Bone: trabecular spacing	0.6	0.9	1.4	-0.8	0.7	1.2
Bone: trabecular thickness	0.4	0.5	0.6	-0.7	0.8	0.7
Bone: trabecular tissue density	3.2	5.7	6.9	-2.6	2.6	1.8
Water consumed over 24 hours	0.8	1.5	1.7	1.3	-1.3	-1.1
Number of responses in last shaping day	0.0	0.0	0.1	-0.1	0.1	0.3