Hub : Genes

Zfpl1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose gene expression Zfpl1 0.04 0.02 1.7e-03 0.02 0.01 0.01 0.01 5.0e-03 1.1e-02 4.4e-02 9.9e-03
2 Liver alternative TSS NM_001286936.1 0.03 0.02 4.2e-03 0.01 0.01 0.01 0.01 1.3e-02 2.0e-02 4.3e-02 4.1e-02
3 Liver gene expression Zfpl1 0.07 0.04 9.0e-06 0.02 0.04 0.04 0.03 4.9e-03 2.5e-05 6.0e-05 5.2e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bone: apparent density0.30.50.8-0.90.7-0.5
Area under the delay curve0.10.10.40.1-0.10.6
BMI with tail1.24.15.6-2.42.4-1.1
BMI without tail0.51.62.4-1.51.6-0.2
Body weight2.611.414.1-3.83.7-2.5
Weight adjusted by age1.72.52.8-1.51.6-1.7
Bone surface5.29.59.9-3.13.0-3.1
Bone volume1.93.34.0-1.81.6-2.0
Breakpoint value in progressive ratio session3.44.14.4-2.01.9-2.1
Number of licking bursts0.30.50.6-0.60.7-0.8
Context. condit. distance diff. score2.53.03.31.6-1.71.8
Locomotion velocity, session 10.10.10.1-0.20.10.4
Locomotion distance, session 10.30.40.6-0.80.80.1
Locomotion velocity, session 22.52.93.7-1.91.9-1.2
Locomotion distance, session 20.50.71.2-1.01.1-0.1
Locomotion velocity, session 30.50.51.10.5-0.51.0
Locomotion distance, session 30.10.10.10.2-0.20.3
Stereotopy head waving bouts, day 31.01.22.40.8-0.81.5
Stereotopy head waving duration, day 30.70.91.20.8-0.91.1
Locomotion velocity, session 70.60.61.10.7-0.61.1
Locomotion distance, session 70.30.30.90.2-0.11.0
Stereotopy head waving bouts, day 70.00.00.10.1-0.1-0.3
Stereotopy head waving duration, day 70.91.11.3-1.00.9-1.2
Locomotion velocity, session 80.70.81.2-1.11.0-0.5
Locomotion distance, session 80.30.50.90.5-0.60.9
Degree of sensitization distance0.10.10.30.00.00.6
Degree of sensitization stereotypy0.70.81.4-0.70.7-1.2
Conditioned locomotion1.61.92.4-1.41.5-1.1
Cocaine response after cond. corrected2.02.43.51.4-1.41.9
Cocaine response after cond. not corrected1.51.82.51.2-1.21.6
Cocaine response before conditioning1.01.21.9-1.00.9-1.4
Saline control response4.05.46.6-2.52.6-1.8
Bone: connectivity density2.13.34.1-2.01.8-1.6
Bone: cortical apparent density0.10.10.1-0.30.3-0.3
Bone: cortical area0.91.41.8-1.21.0-1.3
Bone: cortical porosity0.20.20.3-0.50.5-0.3
Bone: cortical porosity0.60.70.8-0.90.9-0.6
Bone: cortical thickness2.74.45.3-2.32.1-1.9
Bone: cortical thickness0.20.30.5-0.70.6-0.0
Bone: cortical tissue density0.20.20.2-0.50.5-0.5
Condit. Reinf. active minus inactive responses0.10.10.2-0.40.4-0.1
Condit. Reinf. active-inactive response ratio0.00.00.1-0.20.1-0.1
Condit. Reinf. active responses0.00.00.0-0.10.10.1
Condit. Reinf. inactive responses0.10.10.20.4-0.30.3
Incentive salience index mean0.20.20.3-0.60.6-0.1
Condit. Reinf. lever presses0.40.50.5-0.70.7-0.7
Condit. Reinf. active minus inactive responses0.10.10.10.3-0.3-0.3
Condit. Reinf. active-inactive response ratio0.50.60.90.9-0.90.1
Condit. Reinf. active responses0.20.20.4-0.30.4-0.6
Condit. Reinf. inactive responses0.40.60.8-0.90.9-0.3
Condit. Reinf. lever presses2.43.44.7-1.61.7-2.2
Condit. Reinf. lever reinforcers received0.50.71.0-0.60.7-1.0
Conditioned reinforcement - actives0.40.71.9-0.10.2-1.4
Conditioned reinforcement - inactives2.13.14.92.0-2.20.6
Conditioned locomotion6.78.711.13.3-3.32.0
Patch foraging indifference point 0 sec0.00.00.1-0.0-0.30.2
Patch foraging indifference point AUC2.74.05.7-1.81.7-2.4
Delay disc. indifference point, 0s delay0.50.61.40.4-0.41.2
Delay disc. indifference point, 16s delay0.80.81.00.9-1.00.7
Delay disc. indifference point, 2s delay0.10.10.20.3-0.40.4
Delay disc. indifference point, 24s delay0.10.10.30.2-0.10.5
Delay disc. indifference point, 4s delay0.40.41.10.2-0.31.1
Delay disc. indifference point, 8s delay0.20.20.60.0-0.10.8
Indifference point function ln k8.114.117.63.5-3.54.2
Indifference point function log k8.114.117.63.5-3.54.2
Patch foraging total patch changes 0 sec0.00.00.0-0.1-0.20.2
Patch foraging total patch changes 12 sec4.76.16.6-2.62.5-2.3
Patch foraging total patch changes 18 sec0.50.81.1-0.90.8-1.0
Patch foraging total patch changes 24 sec1.83.13.4-1.81.6-1.8
Patch foraging total patch changes 6 sec0.71.11.8-1.31.1-0.7
Patch foraging time to switch 0 sec1.22.62.9-1.61.7-1.4
Patch foraging water rate 0 sec3.16.47.92.8-2.62.1
Patch foraging water rate 12 sec6.714.114.43.8-3.73.7
Patch foraging water rate 18 sec3.24.96.32.1-2.02.5
Patch foraging water rate 24 sec4.36.06.62.6-2.42.4
Patch foraging water rate 6 sec5.47.88.62.9-2.62.9
Seeking ratio, delayed vs. immediate footshock0.20.30.50.5-0.20.7
Distance traveled before self-admin0.91.21.7-1.00.9-1.3
Distance traveled after self-admin0.30.40.7-0.60.4-0.8
Extensor digitorum longus weight7.830.635.2-5.95.9-4.7
Bone: elastic displacement1.11.31.71.0-1.01.3
Bone: elastic work0.60.71.2-1.11.0-0.2
Bone: endosteal estimation0.61.41.41.2-1.21.2
Bone: endosteal perimeter0.71.51.91.4-1.40.8
Epididymis fat weight2.79.212.03.5-3.32.2
Delta time in closed arm before/after self-admin0.30.30.6-0.40.30.8
Delta time in open arm before/after self-admin0.90.82.1-0.50.4-1.5
Diff in mean of infusions in LGA sessions0.50.60.6-0.80.8-0.8
Delay discount exponential model param0.10.10.30.00.0-0.5
Extinction: sum of active levers before priming2.32.63.1-1.81.6-1.4
Active lever presses in extinction session 64.74.75.9-2.02.0-2.4
Bone: final force2.84.45.0-2.22.1-2.0
Bone: final moment2.54.04.6-2.22.0-1.9
Food consumed during 24 hour testing period0.20.30.8-0.20.3-0.9
Glucose3.04.85.82.1-2.02.4
Heart weight1.92.95.81.2-1.22.4
Delay discount hyperbolic model param0.10.10.20.00.1-0.5
Intermittent access intake day 1-15 change0.61.32.01.4-1.40.2
Intermittent access intake escalation0.51.01.61.2-1.3-0.1
Intermittent access intake escalation 20.80.91.41.1-1.2-0.1
Intermitt. access day 1 inactive lever presses0.00.20.40.4-0.60.1
Intermitt. access day 15 inactive lever presses1.02.03.01.6-1.70.6
Intermitt. access escalation Index3.14.44.92.0-2.12.2
Intermittent access day 1 total infusions1.93.13.51.9-1.81.5
Intermittent access day 15 total infusions3.95.97.92.8-2.81.3
Intermittent access terminal intake (last 3 days)3.44.56.32.5-2.51.1
Intermittent access total infusions3.13.74.82.2-2.11.3
Intermittent access day 1 locomotion1.92.52.91.7-1.71.3
Intermittent access day 15 total locomotion2.54.56.62.5-2.60.9
Intermittent access total locomotion5.46.58.82.9-3.01.4
Intermittent access standard deviation0.81.62.41.4-1.50.6
Left kidney weight0.52.42.81.6-1.71.3
Right kidney weight0.21.01.31.1-1.10.7
Cocaine induced anxiety0.10.10.4-0.20.1-0.6
Post-drug Anxiety0.90.91.2-0.90.9-1.1
Baseline Anxiety0.20.30.4-0.60.7-0.1
Tail length0.41.72.1-1.41.4-0.9
Length with tail1.98.29.9-3.13.1-2.3
Length without tail1.96.27.5-2.72.7-1.9
Times rat made contact with spout0.40.40.6-0.80.8-0.3
Lifetime Intake2.42.93.61.9-1.81.3
Liver weight, left1.01.72.01.2-1.21.4
Liver weight, right2.95.06.92.0-2.12.6
Locomotor activity2.64.04.72.0-1.82.2
Locomotor testing distance2.95.26.72.2-2.02.6
Locomotor testing rearing2.24.56.01.9-2.02.4
Locomotion in novel chamber4.65.97.02.6-2.61.9
Locomotion in novel chamber post-restriction2.43.94.92.2-2.21.4
Fecal boli incidents, locomotor time 10.30.41.1-0.2-0.1-1.0
Change in fecal boli incidents, locomotor task0.40.41.00.10.11.0
Time >=10cm from walls, locomotor time 10.40.40.70.7-0.90.2
Bouts of movement, locomotor time 12.32.63.3-1.41.6-1.8
Total resting periods, locomotor time 11.61.82.7-1.11.2-1.6
Rest time, locomotor task time 11.01.31.91.4-1.20.7
Distance moved, locomotor task time 10.00.10.1-0.30.20.1
Vertical activity count, locomotor time 10.61.41.51.2-1.21.2
Time >=10cm from walls, locomotor time 20.30.40.9-0.40.3-1.0
Bouts of movement, locomotor time 20.40.60.7-0.70.8-0.8
Total resting periods, locomotor time 20.10.20.3-0.40.5-0.5
Rest time, locomotor task time 22.12.73.11.7-1.61.5
Distance moved, locomotor task time 21.31.61.7-1.31.3-1.2
Vertical activity count, locomotor time 20.00.00.10.1-0.00.2
Light reinforcement 10.00.10.10.2-0.40.2
Light reinforcement 20.40.61.00.9-1.0-0.1
Bone: marrow area0.81.61.81.3-1.21.3
Bone: maximum diameter0.40.81.6-0.60.5-1.3
Bone: maximum force3.56.26.7-2.62.5-2.4
Bone: maximum moment3.25.56.2-2.52.4-2.2
Mean time between licks in bursts0.10.20.3-0.50.60.4
Mean num. licks in bursts0.20.40.70.5-0.50.8
Cd content in liver0.91.01.51.2-1.20.2
Co content in liver1.51.72.01.2-1.21.4
Cu content in liver0.00.00.00.1-0.20.2
Fe content in liver0.10.10.2-0.40.4-0.3
K content in liver0.20.20.4-0.60.50.0
Mg content in liver0.70.81.40.7-0.71.2
Mn content in liver4.14.55.2-2.02.1-2.3
Na content in liver0.50.50.7-0.80.6-0.8
Rb content in liver2.93.44.21.7-1.82.0
Se content in liver0.10.10.20.4-0.3-0.3
Sr content in liver3.73.23.7-1.71.7-1.9
Zn content in liver0.30.30.5-0.70.5-0.3
Bone: minimum diameter0.71.21.31.0-1.11.2
Time in familiar zone, hab. session 10.30.30.40.5-0.50.6
Time in novel zone, hab. session 10.20.20.40.4-0.30.6
Total zone transitions, hab. session 10.60.91.0-1.01.0-0.8
Total locomotion distance, hab. session 10.30.40.50.5-0.60.7
Locomotion velocity, hab. session 10.00.00.10.1-0.10.2
Time in familiar zone, hab. session 20.20.20.50.1-0.20.7
Time in novel zone, hab. session 20.10.10.2-0.30.4-0.4
Total zone transitions, hab. session 21.21.52.2-1.41.5-0.5
Total locomotion distance, hab. session 20.20.20.6-0.00.10.8
Locomotion velocity, hab. session 20.20.20.60.2-0.20.8
Novel to familiar place preference ratio1.82.03.2-1.21.1-1.8
Novelty place preference0.91.01.9-0.80.7-1.4
Time in novel zone, NPP test0.70.71.3-0.60.6-1.2
Total zone transitions, NPP test2.43.44.2-2.02.0-1.5
Total locomotion distance, NPP test0.10.10.1-0.30.30.3
Locomotion velocity, NPP test0.10.10.1-0.30.40.1
Intraocular pressure0.81.11.71.3-1.3-0.2
Delta distance traveled before/after self-admin0.30.40.60.5-0.50.8
Delta ambulatory time before/after self-admin0.10.20.40.2-0.20.6
Parametrial fat weight3.47.99.33.0-3.02.4
Pavlov. Cond. lever latency0.20.30.40.5-0.60.4
Pavlov. Cond. magazine entry latency0.30.40.6-0.60.8-0.5
Pavlov. Cond. change in total contacts0.30.30.7-0.30.4-0.8
Pavlov. Cond. index score0.30.40.5-0.50.7-0.7
Pavlov. Cond. latency score0.20.20.3-0.40.6-0.4
Pavlov. Cond. lever contacts0.10.10.1-0.20.4-0.0
Pavlov. Cond. magazine entry number0.60.81.20.7-0.81.1
Pavlov. Cond. intertrial magazine entries0.50.61.00.9-1.00.3
Pavlov. Cond. lever-magazine prob. diff.0.60.70.8-0.70.9-0.9
Pavlov. Cond. response bias0.40.50.7-0.50.6-0.8
Pavlov. Cond. lever latency0.91.22.10.9-0.91.4
Pavlov. Cond. magazine entry latency4.85.86.3-2.52.4-2.3
Pavlov. Cond. change in total contacts2.23.55.6-1.61.6-2.4
Pavlov. Cond. index score3.14.25.3-2.01.9-2.3
Pavlov. Cond. latency score2.73.54.6-1.81.7-2.1
Pavlov. Cond. lever contacts0.91.32.1-0.90.9-1.5
Pavlov. Cond. magazine entry number8.510.611.13.2-3.23.3
Pavlov. Cond. intertrial magazine entries1.01.51.81.3-1.31.0
Pavlov. Cond. lever-magazine prob. diff.3.85.06.1-2.12.1-2.5
Pavlov. Cond. response bias2.73.74.5-1.81.8-2.1
Time in closed arm before self-admin0.20.20.30.6-0.5-0.1
Time in closed arm after self-admin0.60.61.00.6-0.71.0
Time in open arm before self-admin1.11.23.20.4-0.41.8
Time in open arm after self-admin0.10.10.1-0.30.4-0.1
Bone: periosteal estimation0.00.00.1-0.1-0.0-0.3
Bone: periosteal perimeter0.10.30.4-0.50.4-0.6
Bone: post-yield work0.50.70.8-0.80.9-0.9
Progressive ratio test 1 active lever presses0.20.20.40.6-0.5-0.0
Progressive ratio test 1 breakpoint0.10.20.30.5-0.4-0.1
Progressive ratio test 1 inactive lever presses0.10.10.20.3-0.4-0.2
Progressive ratio test 2 active lever presses1.92.23.21.8-1.80.6
Progressive ratio test 2 breakpoint1.92.23.21.8-1.70.5
Progressive ratio test 2 inactive lever presses5.38.511.23.3-3.41.8
Incentive Sensitization - Responses0.00.00.10.2-0.1-0.2
Incentive Sensitization - Breakpoint0.10.10.10.4-0.3-0.1
Sum of active levers in priming session hrs 5-63.23.06.8-1.11.0-2.6
Progressive ratio0.91.42.2-1.21.5-0.8
Food seeking constrained by brief footshock0.00.00.0-0.20.20.2
Seeking ratio, punishment vs. effort1.82.62.91.5-1.71.7
Retroperitoneal fat weight10.142.945.66.7-6.76.2
Reaction time number correct0.20.40.4-0.60.6-0.6
Reaction time mean minus median2.66.67.7-2.42.5-2.8
Reaction time mean minus median AUC1.43.54.3-1.71.8-2.1
Reaction time num false alarms1.01.42.70.8-0.91.7
Reaction time num false alarms AUC0.30.41.20.1-0.21.1
Reaction time trials correct on left0.20.40.4-0.60.6-0.6
Reaction time trials on left0.30.50.6-0.70.7-0.7
Reaction time mean0.20.30.8-0.30.3-0.9
Reaction time mean AUC0.20.20.7-0.20.2-0.8
Median of all reaction times0.10.10.10.4-0.4-0.2
Reaction time omissions2.13.03.2-1.61.8-1.8
Reaction time false alarm rate0.81.12.30.7-0.81.5
Reaction time premature initiation rate2.12.94.2-2.02.0-0.8
Reaction time premature initiations2.85.06.6-2.52.6-1.5
Std. dev. reaction times1.22.23.2-1.31.3-1.8
Reaction time trials completed0.30.50.6-0.70.7-0.7
Reaction time trials AUC0.10.20.3-0.50.5-0.5
Run reversals in cocaine runway, females0.40.40.7-0.50.50.9
Run reversals in cocaine runway, males0.30.30.50.6-0.70.3
Latency to leave start box in cocaine runway0.10.10.20.4-0.30.4
Latency to leave start box in cocaine runway, F0.00.00.10.1-0.10.2
Latency to leave start box in cocaine runway, M0.00.00.00.1-0.10.2
Std. dev. time between licks in bursts0.20.30.90.2-0.11.0
Total sessions with >9 infusions0.00.00.00.10.00.2
Short access day 1 total inactive lever presses2.83.73.92.0-2.01.8
Short access day 10 total inactive lever presses0.51.21.50.9-1.11.2
Short access day 1 total infusions1.62.12.21.5-1.41.5
Short access day 10 total infusions0.40.60.60.8-0.70.7
Short access total infusions0.60.70.90.8-0.71.0
Short access day 1 locomotion1.72.12.61.5-1.61.3
Short access day 10 total locomotion0.61.11.51.2-1.20.7
Short access total locomotion1.31.62.01.4-1.41.0
One hour access (0.3 mA shock)6.67.69.33.0-3.02.1
Compulsive drug intake1.31.52.3-1.51.5-0.3
One hour access (shock baseline)5.17.910.53.2-3.21.7
Social response proportion0.91.01.3-1.00.8-1.2
Social responses0.20.30.4-0.60.5-0.6
Social time0.30.40.5-0.70.7-0.6
Soleus weight4.413.114.23.7-3.83.4
Bone: stiffness2.94.75.0-2.22.1-2.2
Tibialis anterior weight11.338.240.4-6.46.3-5.9
Time to tail flick, vehicle, before self-admin0.30.30.3-0.60.6-0.4
Time to tail flick, vehicle, after self-admin0.30.40.7-0.80.80.1
Time to tail flick, test, before self-admin3.03.14.41.6-1.52.1
Time to tail flick, test, after self-admin0.20.20.5-0.20.3-0.7
Delta time to tail flick, vehicle, before/after SA0.20.20.3-0.50.50.1
Delta time to tail flick, test, before/after SA3.53.66.3-1.51.5-2.5
Tibia length1.84.99.2-1.71.6-3.0
Ambulatory time before self-admin0.60.91.7-0.80.7-1.3
Ambulatory time after self-admin0.10.20.30.4-0.6-0.0
Bone: tissue strength0.00.00.00.00.1-0.2
Total heroin consumption5.86.87.0-2.62.6-2.6
Bone: trabecular number0.71.21.4-1.11.0-1.2
Bone: trabecular spacing0.60.91.40.8-0.71.2
Bone: trabecular thickness0.40.50.60.7-0.80.7
Bone: trabecular tissue density3.85.76.92.6-2.61.8
Water consumed over 24 hours1.11.51.7-1.31.3-1.1
Number of responses in last shaping day0.00.00.10.1-0.10.3