Hub : Genes

Yif1a

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	gene expression	Yif1a	0.19	0.09	1.4e-14	0.1	0.1	0.1	0.1	1.5e-11	2.1e-11	3.3e-11	2.0e-11
2	NAcc	gene expression	Yif1a	0.04	0.03	3.1e-05	0.03	0.03	0.03	0.02	1.0e-04	3.5e-05	3.7e-05	1.1e-04
3	BLA	gene expression	Yif1a	0.11	0.11	8.4e-03	0.03	0.04	0.05	0.04	1.7e-02	4.1e-03	1.4e-03	2.1e-03
4	PL	gene expression	Yif1a	0.06	0.04	1.3e-04	0.05	0.04	0.04	0.04	5.1e-06	2.1e-05	2.4e-05	1.0e-05

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bone: apparent density	1.8	3.3	5.9	0.8	-2.4	1.3	2.2
Area under the delay curve	0.2	0.3	0.6	-0.4	-0.7	0.1	0.8
BMI with tail	4.6	16.0	25.2	2.2	-4.5	3.7	5.0
BMI without tail	1.5	8.0	11.0	1.7	-2.9	3.3	3.2
Body weight	2.9	12.9	16.2	3.5	-3.7	4.0	3.1
Weight adjusted by age	0.5	1.5	3.0	1.7	-0.8	1.5	0.3
Bone surface	3.9	7.7	13.8	2.8	-3.7	1.9	2.3
Bone volume	2.1	4.1	7.6	1.5	-2.8	1.6	2.0
Breakpoint value in progressive ratio session	1.4	2.5	4.9	2.2	-1.8	1.1	0.9
Number of licking bursts	0.1	0.2	0.5	0.5	-0.7	0.1	0.2
Context. condit. distance diff. score	1.0	1.3	2.7	-1.6	1.2	-1.0	0.0
Locomotion velocity, session 1	0.1	0.2	0.3	-0.2	0.5	0.4	-0.4
Locomotion distance, session 1	1.6	2.0	3.3	0.4	-1.6	1.4	1.8
Locomotion velocity, session 2	3.2	3.8	7.3	1.7	-1.7	2.7	1.6
Locomotion distance, session 2	1.9	2.7	5.5	0.8	-1.5	2.3	1.5
Locomotion velocity, session 3	0.2	0.2	0.5	-0.3	-0.4	0.2	0.7
Locomotion distance, session 3	0.0	0.0	0.1	-0.0	0.0	0.0	-0.3
Stereotopy head waving bouts, day 3	0.5	0.6	1.3	-1.2	0.1	0.3	1.0
Stereotopy head waving duration, day 3	0.4	0.5	1.6	-1.3	0.2	-0.3	0.6
Locomotion velocity, session 7	1.0	1.1	3.2	-0.3	-0.5	0.8	1.8
Locomotion distance, session 7	0.6	0.8	1.5	0.1	-0.4	1.2	1.2
Stereotopy head waving bouts, day 7	0.2	0.3	0.4	-0.0	-0.6	-0.6	0.6
Stereotopy head waving duration, day 7	0.9	1.2	2.4	1.0	-1.6	0.1	1.1
Locomotion velocity, session 8	0.5	0.6	1.3	1.1	-0.5	0.8	-0.0
Locomotion distance, session 8	0.3	0.4	0.7	-0.7	0.1	0.5	0.9
Degree of sensitization distance	0.7	0.7	2.0	0.2	-0.6	0.8	1.4
Degree of sensitization stereotypy	0.5	0.6	1.0	1.0	-1.0	-0.2	0.6
Conditioned locomotion	1.4	1.6	3.4	1.6	-0.6	1.8	0.3
Cocaine response after cond. corrected	0.8	1.2	2.4	-1.0	1.1	-1.5	-0.3
Cocaine response after cond. not corrected	0.7	1.0	2.7	-0.9	0.8	-1.6	-0.2
Cocaine response before conditioning	0.3	0.4	1.0	0.7	-1.0	0.4	0.2
Saline control response	2.4	3.3	4.5	2.1	-2.1	1.8	0.9
Bone: connectivity density	3.9	6.2	10.3	2.0	-3.2	1.9	2.6
Bone: cortical apparent density	0.1	0.1	0.3	0.5	0.3	0.0	-0.3
Bone: cortical area	0.3	0.5	1.1	1.0	-0.5	0.9	0.0
Bone: cortical porosity	0.6	0.7	1.3	0.2	-0.9	1.2	0.6
Bone: cortical porosity	1.2	1.3	3.3	0.6	-1.1	1.8	0.7
Bone: cortical thickness	1.6	2.6	6.5	2.5	-0.4	1.9	-0.5
Bone: cortical thickness	0.8	0.9	2.7	0.9	0.2	1.6	-0.4
Bone: cortical tissue density	0.1	0.2	0.5	0.7	0.3	0.2	-0.3
Condit. Reinf. active minus inactive responses	0.3	0.4	0.6	0.6	-0.8	-0.0	0.7
Condit. Reinf. active-inactive response ratio	0.2	0.3	0.7	0.3	-0.4	-0.9	0.2
Condit. Reinf. active responses	0.3	0.4	0.7	0.6	-0.6	0.5	0.8
Condit. Reinf. inactive responses	0.3	0.4	1.1	0.1	-0.1	1.0	0.7
Incentive salience index mean	0.8	1.0	1.8	0.7	-1.0	0.8	1.4
Condit. Reinf. lever presses	0.6	0.9	1.5	0.8	-0.7	0.8	1.2
Condit. Reinf. active minus inactive responses	0.5	0.7	2.3	-0.5	-0.5	-1.5	0.2
Condit. Reinf. active-inactive response ratio	0.7	1.1	3.3	-1.1	0.1	-1.8	-0.1
Condit. Reinf. active responses	0.5	0.7	2.1	0.0	-1.4	-0.3	0.8
Condit. Reinf. inactive responses	1.3	1.9	2.9	0.9	-1.7	1.6	1.1
Condit. Reinf. lever presses	1.4	2.1	3.9	1.5	-2.0	1.1	0.9
Condit. Reinf. lever reinforcers received	0.5	0.8	2.4	0.3	-1.6	-0.1	0.7
Conditioned reinforcement - actives	0.0	0.2	0.6	-0.0	0.4	0.0	-0.8
Conditioned reinforcement - inactives	0.9	2.4	2.9	-1.7	1.4	-1.5	-1.6
Conditioned locomotion	4.7	7.0	10.8	-3.3	2.8	-2.3	-2.0
Patch foraging indifference point 0 sec	0.0	0.1	0.3	-0.5	-0.3	-0.1	0.1
Patch foraging indifference point AUC	0.6	1.4	4.1	2.0	-1.0	0.7	0.1
Delay disc. indifference point, 0s delay	0.5	0.5	1.1	-1.1	-0.2	0.6	0.8
Delay disc. indifference point, 16s delay	0.3	0.5	1.1	-0.9	-0.1	-1.0	0.1
Delay disc. indifference point, 2s delay	0.1	0.1	0.4	-0.6	-0.2	-0.3	0.2
Delay disc. indifference point, 24s delay	0.0	0.1	0.2	-0.1	0.4	0.1	-0.3
Delay disc. indifference point, 4s delay	0.2	0.2	0.5	-0.5	-0.4	0.3	0.7
Delay disc. indifference point, 8s delay	0.1	0.1	0.3	-0.3	-0.4	0.1	0.6
Indifference point function ln k	2.2	6.8	15.1	-3.9	2.9	-1.7	-1.0
Indifference point function log k	2.2	6.8	15.1	-3.9	2.9	-1.7	-1.0
Patch foraging total patch changes 0 sec	0.0	0.1	0.2	-0.5	0.1	0.1	-0.2
Patch foraging total patch changes 12 sec	3.4	4.6	6.1	2.5	-2.3	2.2	1.4
Patch foraging total patch changes 18 sec	0.3	0.7	1.3	1.0	-1.1	0.5	0.7
Patch foraging total patch changes 24 sec	0.3	0.9	2.1	1.5	-0.9	0.8	0.2
Patch foraging total patch changes 6 sec	0.8	1.4	2.4	1.3	-1.6	0.8	0.9
Patch foraging time to switch 0 sec	1.5	5.7	7.7	1.9	-2.8	2.2	2.6
Patch foraging water rate 0 sec	2.6	9.6	12.4	-2.9	3.5	-3.1	-2.9
Patch foraging water rate 12 sec	3.4	13.9	18.6	-4.3	4.3	-2.8	-3.3
Patch foraging water rate 18 sec	2.0	4.5	6.9	-2.6	2.2	-1.8	-1.7
Patch foraging water rate 24 sec	5.2	7.5	10.9	-2.8	3.3	-2.3	-2.3
Patch foraging water rate 6 sec	5.1	7.5	10.5	-2.9	3.2	-2.5	-2.3
Seeking ratio, delayed vs. immediate footshock	0.3	0.4	0.7	-0.2	-0.7	0.6	0.8
Distance traveled before self-admin	0.3	0.7	1.2	0.6	-1.1	0.7	0.9
Distance traveled after self-admin	0.1	0.1	0.2	0.4	-0.5	0.2	0.2
Extensor digitorum longus weight	5.5	21.9	36.2	6.0	-3.9	5.3	2.9
Bone: elastic displacement	1.7	2.2	3.6	-0.9	1.9	-1.2	-1.7
Bone: elastic work	0.3	0.4	1.2	1.1	0.1	0.7	-0.1
Bone: endosteal estimation	0.6	1.4	3.5	-1.9	-0.3	-0.4	1.4
Bone: endosteal perimeter	0.8	2.1	3.9	-2.0	-0.5	-1.6	1.3
Epididymis fat weight	1.6	8.1	14.9	-3.9	2.8	-2.8	-1.4
Delta time in closed arm before/after self-admin	0.9	0.9	2.8	0.7	-0.1	1.7	0.4
Delta time in open arm before/after self-admin	0.1	0.1	0.2	0.5	-0.2	-0.4	-0.3
Diff in mean of infusions in LGA sessions	0.2	0.4	1.4	1.2	-0.5	-0.0	-0.1
Delay discount exponential model param	0.2	0.2	0.4	0.2	0.6	-0.1	-0.6
Extinction: sum of active levers before priming	2.0	3.0	4.1	1.8	-2.0	1.2	1.8
Active lever presses in extinction session 6	1.4	1.4	3.7	1.9	-1.2	0.8	0.0
Bone: final force	1.9	3.1	5.6	1.7	-1.6	2.4	1.1
Bone: final moment	1.8	2.9	5.5	1.6	-1.5	2.3	1.1
Food consumed during 24 hour testing period	0.3	0.7	2.0	-0.0	0.5	-0.6	-1.4
Glucose	1.2	2.0	5.0	-2.2	0.1	-1.3	1.1
Heart weight	0.8	1.2	3.0	-1.2	-0.6	0.1	1.7
Delay discount hyperbolic model param	0.2	0.2	0.4	0.3	0.6	-0.1	-0.7
Intermittent access intake day 1-15 change	0.3	1.7	2.2	-1.2	1.5	-1.2	-1.4
Intermittent access intake escalation	0.3	1.7	2.1	-1.0	1.5	-1.2	-1.4
Intermittent access intake escalation 2	1.1	1.9	2.4	-1.1	1.5	-1.5	-1.4
Intermitt. access day 1 inactive lever presses	0.0	0.6	2.1	-0.1	0.4	-1.4	-0.3
Intermitt. access day 15 inactive lever presses	0.3	1.5	4.1	-1.0	0.6	-2.0	-0.6
Intermitt. access escalation Index	0.6	2.0	5.8	-2.4	1.1	-0.9	-0.0
Intermittent access day 1 total infusions	0.3	1.0	2.5	-1.6	-0.5	-0.1	1.1
Intermittent access day 15 total infusions	1.0	2.5	5.3	-2.3	1.3	-1.6	-0.9
Intermittent access terminal intake (last 3 days)	1.0	1.8	3.8	-2.0	0.8	-1.5	-0.5
Intermittent access total infusions	0.7	0.8	2.6	-1.6	0.1	-0.7	0.3
Intermittent access day 1 locomotion	0.3	0.5	1.5	-1.2	-0.2	-0.5	0.7
Intermittent access day 15 total locomotion	0.4	1.6	4.0	-2.0	0.9	-1.1	-0.7
Intermittent access total locomotion	1.7	2.0	6.3	-2.5	0.7	-1.1	-0.2
Intermittent access standard deviation	0.3	1.3	1.8	-1.1	1.3	-1.0	-1.2
Left kidney weight	0.2	1.9	4.9	-2.2	1.5	0.6	-0.0
Right kidney weight	0.2	1.7	3.0	-1.7	1.7	-0.3	-1.0
Cocaine induced anxiety	0.0	0.0	0.1	0.3	-0.2	0.2	-0.0
Post-drug Anxiety	0.3	0.4	0.8	0.9	-0.6	0.4	0.2
Baseline Anxiety	0.0	0.0	0.1	0.4	-0.1	-0.1	-0.1
Tail length	0.2	0.9	1.6	1.3	0.2	1.2	-0.8
Length with tail	0.7	3.1	7.9	2.8	-1.0	1.9	-0.1
Length without tail	0.4	2.2	5.7	2.4	-1.0	1.4	-0.2
Times rat made contact with spout	0.6	0.7	1.0	0.7	-1.0	0.7	0.8
Lifetime Intake	0.4	0.5	1.8	-1.3	-0.1	-0.3	0.4
Liver weight, left	0.7	1.2	2.4	-1.3	1.6	-0.0	-0.7
Liver weight, right	1.1	1.9	3.7	-1.9	1.7	-0.6	-0.8
Locomotor activity	2.1	3.2	4.4	-2.0	2.1	-1.1	-1.8
Locomotor testing distance	1.5	3.7	5.3	-2.2	2.3	-1.2	-1.8
Locomotor testing rearing	0.6	2.3	4.0	-2.0	1.4	-1.2	-1.3
Locomotion in novel chamber	3.2	4.3	8.4	-2.9	2.0	-1.7	-1.3
Locomotion in novel chamber post-restriction	0.8	2.5	5.2	-2.3	1.5	-1.4	-0.9
Fecal boli incidents, locomotor time 1	0.1	0.2	0.7	0.2	0.1	-0.8	-0.4
Change in fecal boli incidents, locomotor task	0.5	0.6	1.6	-0.2	-0.4	1.3	0.7
Time >=10cm from walls, locomotor time 1	0.3	0.4	0.7	-0.8	-0.6	-0.1	0.9
Bouts of movement, locomotor time 1	0.5	0.7	2.0	1.4	-0.8	-0.3	-0.1
Total resting periods, locomotor time 1	0.5	0.6	1.3	1.1	-0.7	-0.6	-0.0
Rest time, locomotor task time 1	1.6	2.5	4.0	-1.6	1.4	-2.0	-1.3
Distance moved, locomotor task time 1	0.4	1.2	1.8	0.5	-1.2	1.0	1.3
Vertical activity count, locomotor time 1	0.0	0.3	0.7	-0.9	0.6	0.4	-0.1
Time >=10cm from walls, locomotor time 2	0.0	0.1	0.2	-0.1	-0.1	-0.4	0.2
Bouts of movement, locomotor time 2	0.2	0.6	1.3	1.1	-0.8	0.5	0.3
Total resting periods, locomotor time 2	0.1	0.4	0.7	0.9	-0.7	0.2	0.3
Rest time, locomotor task time 2	1.1	1.8	3.0	-1.7	1.4	-1.3	-0.9
Distance moved, locomotor task time 2	0.5	0.6	1.6	1.3	-0.8	0.5	0.4
Vertical activity count, locomotor time 2	0.2	0.6	1.0	0.1	1.0	0.5	-1.0
Light reinforcement 1	0.0	0.1	0.2	-0.5	0.4	0.1	-0.5
Light reinforcement 2	0.7	1.5	3.0	-1.1	0.9	-1.7	-1.0
Bone: marrow area	0.6	1.5	3.8	-1.9	-0.3	-0.5	1.4
Bone: maximum diameter	0.0	0.1	0.3	0.0	-0.2	-0.5	-0.2
Bone: maximum force	2.4	4.7	7.3	2.1	-2.7	1.7	2.1
Bone: maximum moment	2.3	4.4	6.8	2.0	-2.6	1.7	2.1
Mean time between licks in bursts	0.0	0.1	0.1	0.1	-0.2	0.4	0.1
Mean num. licks in bursts	0.0	0.1	0.2	-0.4	0.2	0.1	0.2
Cd content in liver	0.8	0.9	1.5	-1.2	0.7	-0.8	-0.9
Co content in liver	2.0	2.4	5.2	-1.3	2.3	-0.5	-1.5
Cu content in liver	0.4	0.4	0.8	-0.1	-0.5	0.9	0.8
Fe content in liver	0.1	0.1	0.1	0.3	0.1	0.1	-0.4
K content in liver	1.1	1.1	1.6	0.8	-1.0	1.1	1.3
Mg content in liver	0.1	0.1	0.3	-0.6	-0.1	-0.2	0.4
Mn content in liver	2.0	2.2	6.1	2.5	-1.6	-0.0	0.4
Na content in liver	0.3	0.3	0.7	0.2	0.4	-0.8	-0.7
Rb content in liver	0.6	0.7	2.0	-1.4	0.4	-0.7	0.1
Se content in liver	0.2	0.2	0.7	-0.3	-0.1	-0.8	-0.2
Sr content in liver	1.1	0.9	2.8	1.7	-0.4	0.6	-0.6
Zn content in liver	0.6	0.7	1.5	0.6	-0.5	1.2	0.8
Bone: minimum diameter	1.0	1.9	4.3	-1.5	-0.9	-0.6	2.1
Time in familiar zone, hab. session 1	0.2	0.2	0.4	-0.5	-0.2	-0.6	0.6
Time in novel zone, hab. session 1	0.4	0.5	0.9	-0.4	0.9	-0.2	-1.0
Total zone transitions, hab. session 1	0.9	1.2	1.7	1.0	-1.1	1.3	1.0
Total locomotion distance, hab. session 1	0.3	0.4	0.7	-0.8	0.2	-0.4	0.8
Locomotion velocity, hab. session 1	0.2	0.2	0.8	-0.3	-0.1	0.2	0.9
Time in familiar zone, hab. session 2	0.1	0.1	0.2	0.3	0.4	-0.1	-0.5
Time in novel zone, hab. session 2	0.3	0.4	0.7	-0.1	-0.8	0.4	0.9
Total zone transitions, hab. session 2	3.7	4.7	8.2	1.0	-2.9	1.8	2.5
Total locomotion distance, hab. session 2	0.9	1.2	3.1	-0.3	-1.2	0.5	1.8
Locomotion velocity, hab. session 2	0.8	1.1	2.8	-0.5	-1.1	0.2	1.7
Novel to familiar place preference ratio	0.7	0.9	1.5	1.2	-1.2	-0.0	0.8
Novelty place preference	0.4	0.5	0.9	0.8	-0.9	-0.3	0.7
Time in novel zone, NPP test	0.3	0.4	0.7	0.7	-0.8	-0.2	0.6
Total zone transitions, NPP test	2.8	4.1	6.4	1.4	-2.1	2.5	1.9
Total locomotion distance, NPP test	0.8	1.1	2.3	-0.2	-0.6	1.3	1.5
Locomotion velocity, NPP test	0.8	1.1	2.3	-0.1	-0.6	1.3	1.5
Intraocular pressure	1.6	2.6	4.1	-0.6	1.7	-2.0	-1.8
Delta distance traveled before/after self-admin	0.2	0.2	0.4	-0.1	0.7	-0.3	-0.6
Delta ambulatory time before/after self-admin	0.1	0.1	0.3	-0.0	0.5	0.1	-0.5
Parametrial fat weight	1.4	3.4	7.9	-2.8	1.8	-1.5	-0.4
Pavlov. Cond. lever latency	0.3	0.4	0.6	-0.5	0.6	-0.7	-0.8
Pavlov. Cond. magazine entry latency	0.6	0.8	1.8	0.3	-1.1	0.4	1.3
Pavlov. Cond. change in total contacts	0.3	0.3	0.4	0.2	-0.6	-0.6	0.6
Pavlov. Cond. index score	0.1	0.1	0.2	0.2	-0.4	-0.0	0.4
Pavlov. Cond. latency score	0.1	0.1	0.4	0.1	-0.4	0.0	0.6
Pavlov. Cond. lever contacts	0.3	0.3	0.6	0.1	-0.4	0.6	0.8
Pavlov. Cond. magazine entry number	0.0	0.1	0.1	-0.4	0.3	0.1	-0.0
Pavlov. Cond. intertrial magazine entries	0.4	0.4	0.7	-0.5	0.7	-0.5	-0.9
Pavlov. Cond. lever-magazine prob. diff.	0.2	0.3	0.5	0.3	-0.6	0.3	0.7
Pavlov. Cond. response bias	0.0	0.0	0.1	0.3	-0.2	0.1	0.1
Pavlov. Cond. lever latency	0.3	0.4	1.0	-0.7	0.5	-1.0	-0.0
Pavlov. Cond. magazine entry latency	3.4	4.8	7.5	2.5	-2.7	1.3	1.9
Pavlov. Cond. change in total contacts	0.7	1.8	3.6	1.6	-1.9	0.4	0.9
Pavlov. Cond. index score	1.7	2.6	4.0	1.9	-2.0	1.2	1.2
Pavlov. Cond. latency score	1.4	2.2	3.2	1.7	-1.8	1.1	1.1
Pavlov. Cond. lever contacts	0.3	0.4	0.7	0.8	-0.7	0.8	0.0
Pavlov. Cond. magazine entry number	4.9	6.4	9.9	-3.1	3.1	-1.6	-1.8
Pavlov. Cond. intertrial magazine entries	0.5	1.2	1.6	-1.3	1.1	-1.0	-0.9
Pavlov. Cond. lever-magazine prob. diff.	2.0	3.1	4.8	2.1	-2.2	1.3	1.3
Pavlov. Cond. response bias	1.5	2.1	3.2	1.7	-1.8	1.1	1.0
Time in closed arm before self-admin	0.3	0.5	1.2	-0.8	-0.1	-1.1	0.1
Time in closed arm after self-admin	0.1	0.1	0.1	-0.3	0.2	-0.2	0.3
Time in open arm before self-admin	0.3	0.3	0.6	-0.3	0.7	0.8	-0.1
Time in open arm after self-admin	0.1	0.1	0.1	0.3	0.1	0.2	-0.3
Bone: periosteal estimation	0.1	0.3	0.6	-0.4	-0.4	0.3	0.8
Bone: periosteal perimeter	0.3	0.5	1.0	0.0	-1.0	-0.4	1.0
Bone: post-yield work	3.9	6.7	15.2	0.5	-3.4	0.2	3.9
Progressive ratio test 1 active lever presses	0.0	0.0	0.0	-0.1	-0.2	0.2	0.0
Progressive ratio test 1 breakpoint	0.0	0.0	0.0	-0.0	-0.2	0.2	0.0
Progressive ratio test 1 inactive lever presses	0.0	0.0	0.1	-0.1	-0.1	-0.2	-0.2
Progressive ratio test 2 active lever presses	0.5	0.7	1.6	-1.2	0.5	-0.9	-0.5
Progressive ratio test 2 breakpoint	0.6	0.8	1.5	-1.2	0.5	-1.0	-0.6
Progressive ratio test 2 inactive lever presses	1.3	4.2	8.9	-3.0	1.6	-2.0	-1.2
Incentive Sensitization - Responses	0.1	0.3	0.6	0.2	-0.8	0.1	0.6
Incentive Sensitization - Breakpoint	0.1	0.1	0.3	-0.0	-0.6	-0.2	0.5
Sum of active levers in priming session hrs 5-6	1.5	1.4	3.1	1.3	0.6	-0.6	-1.8
Progressive ratio	1.4	4.3	6.0	0.9	-2.4	2.1	2.4
Food seeking constrained by brief footshock	0.2	0.2	0.5	0.5	-0.3	0.7	0.1
Seeking ratio, punishment vs. effort	1.3	2.9	4.7	-1.2	2.2	-1.4	-1.8
Retroperitoneal fat weight	5.6	24.9	49.8	-7.1	4.7	-4.8	-2.0
Reaction time number correct	0.1	0.3	0.9	0.3	0.4	-0.2	-1.0
Reaction time mean minus median	0.5	3.2	7.3	2.7	-1.8	1.1	0.9
Reaction time mean minus median AUC	0.2	1.4	4.4	2.1	-0.9	0.6	0.0
Reaction time num false alarms	0.2	0.4	1.2	-0.6	1.1	-0.0	-0.3
Reaction time num false alarms AUC	0.0	0.1	0.3	0.2	0.5	0.3	0.0
Reaction time trials correct on left	0.1	0.3	0.9	0.3	0.4	-0.2	-1.0
Reaction time trials on left	0.1	0.3	1.0	0.4	0.4	-0.2	-1.0
Reaction time mean	0.0	0.1	0.2	0.4	-0.2	0.5	-0.1
Reaction time mean AUC	0.0	0.0	0.1	0.3	-0.3	0.2	-0.0
Median of all reaction times	0.0	0.1	0.1	-0.4	0.1	0.2	-0.2
Reaction time omissions	1.1	1.8	4.8	2.2	-1.2	0.9	0.5
Reaction time false alarm rate	0.1	0.1	0.3	-0.2	0.6	0.1	0.3
Reaction time premature initiation rate	1.1	1.8	3.3	1.8	-1.1	1.5	0.5
Reaction time premature initiations	0.6	1.9	4.8	2.2	-1.0	1.4	-0.1
Std. dev. reaction times	0.3	1.0	2.4	1.5	-1.0	0.8	0.2
Reaction time trials completed	0.1	0.3	1.0	0.4	0.4	-0.2	-1.0
Reaction time trials AUC	0.1	0.3	0.8	0.3	0.4	-0.2	-0.9
Run reversals in cocaine runway, females	1.8	2.0	3.4	0.4	-1.1	1.8	1.8
Run reversals in cocaine runway, males	1.5	1.6	3.2	-0.1	1.8	-0.5	-1.7
Latency to leave start box in cocaine runway	0.4	0.6	1.4	-0.3	-0.8	-0.3	1.2
Latency to leave start box in cocaine runway, F	0.3	0.4	0.9	-0.3	-0.6	-0.2	1.0
Latency to leave start box in cocaine runway, M	0.2	0.2	0.3	0.3	-0.5	-0.2	0.5
Std. dev. time between licks in bursts	0.3	0.5	1.3	-0.2	0.8	1.1	-0.3
Total sessions with >9 infusions	0.9	1.1	1.5	0.2	-1.2	1.2	1.2
Short access day 1 total inactive lever presses	0.6	1.2	3.3	-1.8	1.0	-0.5	-0.5
Short access day 10 total inactive lever presses	0.1	0.7	2.1	-0.4	0.5	-1.5	-0.3
Short access day 1 total infusions	0.3	0.6	1.7	-1.3	0.1	-0.5	0.6
Short access day 10 total infusions	1.2	2.1	4.0	-0.2	-1.7	1.2	2.0
Short access total infusions	0.6	0.8	1.5	-0.3	-0.9	0.8	1.2
Short access day 1 locomotion	0.2	0.4	0.8	-0.8	-0.0	-0.9	0.2
Short access day 10 total locomotion	0.1	0.3	0.6	-0.8	-0.2	0.0	0.7
Short access total locomotion	0.2	0.3	1.0	-1.0	-0.1	-0.3	0.5
One hour access (0.3 mA shock)	3.4	4.0	6.5	-2.4	1.6	-2.6	-1.1
Compulsive drug intake	0.5	0.8	1.7	1.3	-0.1	1.2	-0.1
One hour access (shock baseline)	1.7	4.3	7.1	-2.7	1.5	-2.6	-1.0
Social response proportion	0.4	0.5	1.2	0.8	-1.1	-0.4	0.1
Social responses	0.1	0.1	0.2	0.5	-0.3	0.0	-0.4
Social time	0.1	0.2	0.4	0.6	-0.2	0.3	-0.6
Soleus weight	2.8	8.3	16.4	-4.1	3.4	-1.7	-1.6
Bone: stiffness	2.2	3.9	6.7	1.9	-2.6	1.4	1.8
Tibialis anterior weight	5.5	18.8	41.4	6.4	-3.0	4.9	0.9
Time to tail flick, vehicle, before self-admin	0.4	0.5	0.8	0.4	-0.8	0.7	0.9
Time to tail flick, vehicle, after self-admin	1.3	2.6	4.7	0.9	-1.6	1.5	2.2
Time to tail flick, test, before self-admin	0.6	0.7	1.7	-1.3	-0.0	0.1	1.0
Time to tail flick, test, after self-admin	0.0	0.0	0.1	0.2	-0.0	-0.2	-0.3
Delta time to tail flick, vehicle, before/after SA	0.8	0.8	1.1	0.7	-1.0	0.7	1.0
Delta time to tail flick, test, before/after SA	1.2	1.5	3.5	1.5	0.6	-0.4	-1.9
Tibia length	0.5	1.3	2.1	1.5	-0.5	1.4	-0.9
Ambulatory time before self-admin	0.2	0.6	1.4	0.7	-1.2	0.0	0.7
Ambulatory time after self-admin	0.1	0.2	0.4	-0.3	-0.4	-0.6	0.4
Bone: tissue strength	0.1	0.1	0.2	-0.1	-0.4	-0.1	0.4
Total heroin consumption	2.4	2.9	6.2	2.5	-1.9	1.0	1.0
Bone: trabecular number	1.8	3.3	6.3	1.2	-2.5	1.3	1.9
Bone: trabecular spacing	0.5	0.7	1.3	-1.0	1.1	0.0	-0.7
Bone: trabecular thickness	0.3	0.4	0.6	-0.5	-0.8	-0.4	0.8
Bone: trabecular tissue density	3.3	5.7	7.8	-2.5	2.8	-2.4	-1.7
Water consumed over 24 hours	0.4	0.7	1.2	1.1	-1.0	0.7	0.0
Number of responses in last shaping day	0.1	0.1	0.2	0.1	0.3	-0.5	-0.3