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chr2:116,853,286-120,258,488

Best TWAS P=4.249838e-09 · Best GWAS P=1.472219e-08 conditioned to 0.11826

Associated models

#	Tissue	Gene	Modality	RNA phenotype	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	Adipose	Anxa5	alternative TSS	ENSRNOT00000104744	0.07	0.05	top1	1	0.05	3.1e-06	5.4	-5.4	7.9e-08	-0.98	0.44	0.37	FALSE
2	Adipose	Anxa5	alternative TSS	ENSRNOT00000109811	0.06	0.03	top1	1	0.03	2.7e-04	5.4	-5.4	6.7e-08	-0.98	0.11	0.07	FALSE
3	Adipose	Anxa5	alternative TSS	ENSRNOT00000019554	0.15	0.12	top1	1	0.12	1.6e-13	5.2	5.2	2.6e-07	0.96	0.78	0.22	FALSE
4	Adipose	Qrfpr	gene expression	ENSRNOG00000014414	0.20	0.09	top1	1	0.10	1.2e-10	5.4	-5.4	6.9e-08	-0.98	0.59	0.41	FALSE
5	Adipose	NA	gene expression	ENSRNOG00000066024	0.04	0.02	top1	1	0.02	9.6e-04	5.7	5.7	1.5e-08	0.94	0.07	0.05	FALSE
6	Adipose	Anxa5	mRNA stability	ENSRNOG00000014453	0.07	0.04	top1	1	0.04	4.3e-05	5.1	-5.1	2.8e-07	-0.96	0.18	0.06	FALSE
7	Adipose	Atp11b	mRNA stability	ENSRNOG00000052116	0.13	0.06	blup	1833	0.06	1.8e-07	5.6	5.4	6.8e-08	0.96	0.36	0.64	FALSE
8	BLA	Qrfpr	gene expression	ENSRNOG00000014414	0.36	0.21	top1	1	0.21	2.9e-11	5.4	5.4	6.9e-08	0.98	0.59	0.41	FALSE
9	Brain	Qrfpr	gene expression	ENSRNOG00000014414	0.67	0.63	enet	239	0.64	1.0e-77	5.4	5.6	1.9e-08	0.98	0.44	0.56	FALSE
10	Brain	Trpc3	intron excision ratio	chr2:119485307:119496374	0.03	0.02	blup	2047	0.02	5.6e-03	5.5	5.3	1.1e-07	0.94	0.37	0.44	FALSE
11	Brain	Trpc3	intron excision ratio	chr2:119485307:119499985	0.11	0.08	blup	2047	0.09	1.8e-08	5.1	-5.3	9.6e-08	-0.95	0.64	0.36	FALSE
12	Brain	Trpc3	intron excision ratio	chr2:119496457:119499985	0.03	0.02	top1	1	0.02	5.2e-03	5.1	5.1	3.2e-07	0.98	0.07	0.03	FALSE
13	Brain	Qrfpr	mRNA stability	ENSRNOG00000014414	0.39	0.28	lasso	32	0.32	5.6e-30	5.4	5.9	4.2e-09	0.81	0.43	0.57	TRUE
14	IL	Qrfpr	gene expression	ENSRNOG00000014414	0.83	0.28	blup	2467	0.31	3.5e-08	5.4	5.2	1.7e-07	0.89	0.45	0.55	FALSE
15	Liver	Dcun1d1	alternative polyA	ENSRNOT00000068334	0.03	0.00	blup	2146	0.01	6.0e-02	5.5	-5.4	5.1e-08	-0.97	0.28	0.28	FALSE
16	Liver	Dcun1d1	gene expression	ENSRNOG00000012734	0.10	0.06	top1	1	0.06	3.0e-07	5.7	-5.7	1.5e-08	-0.96	0.28	0.69	FALSE
17	Liver	Mccc1	gene expression	ENSRNOG00000013293	0.33	0.22	blup	2259	0.24	6.7e-26	5.5	5.4	5.9e-08	0.93	0.57	0.43	FALSE
18	Liver	Dcun1d1	isoform ratio	ENSRNOT00000080100	0.03	0.00	blup	2146	0.00	1.4e-01	5.5	-5.6	2.6e-08	-0.95	0.32	0.29	FALSE
19	Liver	Anxa5	intron excision ratio	chr2:119326053:119327400	0.03	0.00	lasso	9	0.01	2.3e-02	5.5	5.3	9.5e-08	0.92	0.42	0.27	FALSE
20	Liver	Bbs7	mRNA stability	ENSRNOG00000015816	0.09	0.07	top1	1	0.06	9.2e-08	5.1	5.1	2.8e-07	0.96	0.67	0.26	FALSE
21	NAcc	Acad9	alternative polyA	ENSRNOT00000089353	0.41	0.08	top1	1	0.08	7.6e-03	5.6	-5.6	2.0e-08	-0.98	0.11	0.05	FALSE
22	NAcc	Acad9	alternative polyA	ENSRNOT00000113867	0.39	0.08	blup	2231	0.08	7.1e-03	5.4	5.5	4.1e-08	0.96	0.36	0.38	FALSE
23	NAcc2	AABR07010085.2	gene expression	ENSRNOG00000056177	0.10	0.01	blup	2311	0.05	1.1e-03	5.5	-5.1	2.6e-07	-0.88	0.47	0.28	FALSE
24	OFC	Qrfpr	gene expression	ENSRNOG00000014414	0.85	0.41	top1	1	0.41	5.7e-11	5.4	5.4	7.2e-08	0.98	0.57	0.38	FALSE
25	OFC	NA	isoform ratio	ENSRNOT00000101042	0.31	0.15	enet	3	0.15	2.5e-04	5.0	-5.2	2.3e-07	-0.70	0.30	0.56	FALSE
26	OFC	NA	isoform ratio	ENSRNOT00000112310	0.37	0.12	lasso	3	0.21	1.1e-05	4.8	5.1	3.0e-07	0.76	0.31	0.67	FALSE
27	PL	Qrfpr	gene expression	ENSRNOG00000014414	0.75	0.39	top1	1	0.39	3.3e-10	5.4	5.4	6.2e-08	0.98	0.51	0.40	FALSE
28	PL2	Qrfpr	gene expression	ENSRNOG00000014414	0.57	0.41	enet	178	0.42	1.7e-24	5.4	5.7	1.2e-08	0.39	0.46	0.54	FALSE
29	PL2	Bbs7	gene expression	ENSRNOG00000015816	0.12	0.05	top1	1	0.05	7.8e-04	5.4	-5.4	6.9e-08	-0.96	0.09	0.06	FALSE
30	PL2	Anxa5	intron excision ratio	chr2:119326053:119327400	0.11	0.01	blup	2313	0.05	1.3e-03	5.5	5.2	1.6e-07	0.91	0.50	0.45	FALSE
31	PL2	Qrfpr	mRNA stability	ENSRNOG00000014414	0.21	0.09	enet	25	0.13	1.1e-07	5.6	5.8	6.6e-09	0.86	0.48	0.52	FALSE

h2: Heritability estimate for the given transcriptomic model. PP3: Posterior probability of two distinct causal variants. PP4: Posterior probability of a single shared causal variant. joint: Whether the RNA phenotype is in the joint model.