Frmd8

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	gene expression	Frmd8	0.26	0.1	0.0e+00	0.18	0.16	0.16	0.17	3.2e-19	3.6e-17	2.7e-17	1.6e-18
2	Adipose	mRNA stability	Frmd8	0.12	0.07	2.7e-09	0.07	0.06	0.06	0.06	1.1e-08	5.0e-07	9.7e-07	1.9e-07
3	Brain	gene expression	Frmd8	0.04	0.03	1.4e-03	0.01	0.02	0	0.01	5.9e-02	3.8e-03	9.5e-02	3.6e-02
4	LHb	gene expression	Frmd8	0.16	0.09	1.3e-03	0.12	0.11	0.09	0.09	1.2e-03	1.4e-03	3.3e-03	3.5e-03
5	NAcc	gene expression	Frmd8	0.03	0.02	2.5e-03	0.02	0.02	0.02	0.02	3.1e-03	5.5e-03	4.5e-03	4.3e-03
6	Liver	gene expression	Frmd8	0.03	0.02	3.0e-03	0.01	0.01	0.01	0.01	2.8e-02	1.1e-02	4.4e-02	3.1e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6
Bone: apparent density	0.4	0.7	2.5	0.7	0.7	0.0	0.3	-1.0	1.6
Area under the delay curve	0.3	0.3	1.2	-0.3	-0.3	0.2	0.1	-1.1	0.8
BMI with tail	2.1	6.6	10.9	3.0	3.0	-1.3	2.9	-1.1	3.3
BMI without tail	1.1	2.2	3.5	1.6	1.6	-0.9	1.9	-1.0	1.6
Body weight	2.6	10.9	18.5	4.3	4.3	-3.3	3.8	1.8	0.4
Weight adjusted by age	1.7	2.0	2.7	1.6	1.6	-1.5	1.2	1.5	-0.6
Bone surface	2.2	3.9	7.8	2.8	2.8	-1.7	1.7	0.9	1.0
Bone volume	0.7	1.2	2.3	1.5	1.5	-0.5	0.5	-0.0	1.5
Breakpoint value in progressive ratio session	2.5	2.8	4.4	2.1	2.1	-1.7	1.5	1.6	-0.4
Number of licking bursts	0.2	0.3	0.5	0.7	0.7	-0.5	0.3	0.5	0.0
Context. condit. distance diff. score	1.9	2.3	3.6	-1.6	-1.6	1.5	-1.4	-1.9	0.7
Locomotion velocity, session 1	0.1	0.2	0.4	0.0	0.0	-0.3	0.6	0.2	-0.7
Locomotion distance, session 1	0.4	0.5	0.8	0.6	0.6	-0.5	0.9	-0.7	0.8
Locomotion velocity, session 2	1.9	2.2	4.0	1.8	1.8	-1.5	2.0	0.6	0.3
Locomotion distance, session 2	0.4	0.6	1.3	0.9	0.9	-0.8	1.1	-0.1	0.5
Locomotion velocity, session 3	0.5	0.5	1.6	-0.5	-0.5	0.8	-0.1	-0.8	1.2
Locomotion distance, session 3	0.0	0.0	0.1	-0.3	-0.3	0.2	-0.1	-0.0	0.1
Stereotopy head waving bouts, day 3	0.8	1.0	1.7	-0.8	-0.8	1.1	-0.4	-1.3	1.2
Stereotopy head waving duration, day 3	0.8	1.0	1.5	-1.0	-1.0	1.1	-0.7	-1.2	0.9
Locomotion velocity, session 7	1.6	1.8	4.3	-0.8	-0.8	1.2	-0.7	-1.8	2.1
Locomotion distance, session 7	0.2	0.3	0.9	-0.2	-0.2	0.4	0.0	-0.9	0.9
Stereotopy head waving bouts, day 7	0.5	0.5	1.1	-0.4	-0.4	0.7	-0.8	-0.6	1.0
Stereotopy head waving duration, day 7	0.5	0.6	1.0	1.0	1.0	-0.6	0.5	0.1	0.8
Locomotion velocity, session 8	1.2	1.5	2.8	1.1	1.1	-1.3	1.7	1.0	-1.1
Locomotion distance, session 8	0.5	0.8	1.5	-0.5	-0.5	0.9	-0.4	-1.2	1.2
Degree of sensitization distance	0.3	0.3	1.0	-0.0	-0.0	0.4	-0.0	-0.9	1.0
Degree of sensitization stereotypy	0.2	0.2	0.4	0.7	0.7	-0.3	-0.0	0.3	0.6
Conditioned locomotion	1.4	1.7	2.4	1.5	1.5	-1.4	1.3	1.1	-0.7
Cocaine response after cond. corrected	1.0	1.2	2.1	-1.5	-1.5	1.1	-0.5	-1.1	0.2
Cocaine response after cond. not corrected	0.8	0.9	1.6	-1.3	-1.3	1.1	-0.4	-1.0	0.2
Cocaine response before conditioning	0.5	0.6	1.0	1.0	1.0	-0.7	0.6	0.7	-0.1
Saline control response	3.6	4.7	6.9	2.6	2.6	-2.4	2.3	1.6	-1.0
Bone: connectivity density	1.2	1.9	3.4	1.9	1.9	-1.1	1.4	-0.2	1.1
Bone: cortical apparent density	0.4	0.5	0.9	0.7	0.7	-0.9	0.7	0.5	-0.6
Bone: cortical area	0.4	0.6	1.3	1.0	1.0	-0.7	0.4	1.2	-0.1
Bone: cortical porosity	0.2	0.2	0.7	0.3	0.3	-0.1	0.3	-0.9	0.6
Bone: cortical porosity	0.5	0.5	0.8	0.9	0.9	-0.7	0.9	-0.4	0.3
Bone: cortical thickness	3.0	4.9	6.3	2.1	2.1	-2.5	2.1	2.5	-1.9
Bone: cortical thickness	1.2	1.4	2.5	0.7	0.7	-1.3	1.2	1.4	-1.6
Bone: cortical tissue density	0.5	0.7	1.2	0.8	0.8	-1.1	0.8	0.6	-0.8
Condit. Reinf. active minus inactive responses	0.1	0.1	0.2	0.5	0.5	-0.4	0.4	-0.2	0.2
Condit. Reinf. active-inactive response ratio	0.0	0.0	0.1	0.1	0.1	-0.3	0.1	-0.2	-0.2
Condit. Reinf. active responses	0.1	0.2	0.6	0.3	0.3	0.1	-0.1	-0.5	0.8
Condit. Reinf. inactive responses	0.4	0.5	1.7	-0.1	-0.1	0.8	-0.5	-0.6	1.3
Incentive salience index mean	0.2	0.3	0.5	0.6	0.6	-0.3	0.5	-0.4	0.7
Condit. Reinf. lever presses	0.2	0.3	0.5	0.7	0.7	-0.2	0.3	0.1	0.7
Condit. Reinf. active minus inactive responses	0.4	0.4	1.0	-0.4	-0.4	0.7	-1.0	-0.6	0.8
Condit. Reinf. active-inactive response ratio	1.5	1.6	2.8	-0.9	-0.9	1.5	-1.7	-0.9	1.5
Condit. Reinf. active responses	0.1	0.1	0.4	0.2	0.2	0.0	-0.3	-0.6	0.6
Condit. Reinf. inactive responses	0.3	0.4	0.8	0.6	0.6	-0.9	0.9	-0.4	-0.1
Condit. Reinf. lever presses	1.2	1.6	3.3	1.8	1.8	-1.2	0.8	1.0	0.2
Condit. Reinf. lever reinforcers received	0.1	0.2	0.3	0.6	0.6	-0.3	-0.0	-0.3	0.4
Conditioned reinforcement - actives	0.3	0.3	0.8	-0.6	-0.6	0.6	-0.9	0.2	0.0
Conditioned reinforcement - inactives	5.4	6.0	10.6	-2.8	-2.8	2.7	-3.3	-1.3	0.7
Conditioned locomotion	6.4	7.7	11.8	-3.4	-3.4	3.0	-3.4	-1.4	0.2
Patch foraging indifference point 0 sec	0.0	0.0	0.1	-0.1	-0.1	0.2	-0.4	-0.1	0.2
Patch foraging indifference point AUC	3.0	3.4	5.1	2.3	2.3	-1.9	1.6	1.9	-0.7
Delay disc. indifference point, 0s delay	0.9	0.9	2.6	-1.0	-1.0	0.6	-0.0	-1.6	0.9
Delay disc. indifference point, 16s delay	1.1	1.1	1.3	-0.9	-0.9	1.1	-1.1	-1.1	1.1
Delay disc. indifference point, 2s delay	0.2	0.2	0.3	-0.4	-0.4	0.5	-0.3	-0.5	0.6
Delay disc. indifference point, 24s delay	0.1	0.1	0.3	-0.3	-0.3	-0.2	0.3	-0.2	-0.5
Delay disc. indifference point, 4s delay	0.3	0.3	1.2	-0.5	-0.5	0.2	0.2	-1.1	0.4
Delay disc. indifference point, 8s delay	0.2	0.2	0.7	-0.3	-0.3	-0.1	0.4	-0.8	0.2
Indifference point function ln k	6.4	9.0	14.4	-3.8	-3.8	3.2	-2.6	-2.7	0.8
Indifference point function log k	6.4	9.0	14.4	-3.8	-3.8	3.2	-2.6	-2.7	0.8
Patch foraging total patch changes 0 sec	0.0	0.0	0.1	-0.0	-0.0	-0.0	-0.1	0.2	-0.3
Patch foraging total patch changes 12 sec	3.8	4.9	8.1	2.9	2.9	-2.4	2.1	1.7	-0.4
Patch foraging total patch changes 18 sec	0.4	0.5	1.0	1.0	1.0	-0.5	0.7	0.4	0.4
Patch foraging total patch changes 24 sec	2.7	3.3	4.0	2.0	2.0	-1.9	1.8	1.9	-1.2
Patch foraging total patch changes 6 sec	0.8	1.2	2.0	1.4	1.4	-1.1	1.2	0.8	-0.1
Patch foraging time to switch 0 sec	1.2	1.9	3.1	1.8	1.8	-0.8	1.2	-0.4	1.7
Patch foraging water rate 0 sec	2.5	4.0	6.7	-2.6	-2.6	1.9	-2.4	-0.2	-1.2
Patch foraging water rate 12 sec	5.1	7.9	15.6	-3.9	-3.9	2.5	-2.5	-1.1	-1.5
Patch foraging water rate 18 sec	2.2	3.0	5.4	-2.3	-2.3	1.7	-1.6	-1.2	-0.4
Patch foraging water rate 24 sec	2.8	3.8	7.2	-2.7	-2.7	1.9	-1.9	-1.0	-0.7
Patch foraging water rate 6 sec	2.3	3.4	6.8	-2.6	-2.6	1.7	-1.5	-0.5	-1.2
Seeking ratio, delayed vs. immediate footshock	0.1	0.2	0.5	-0.0	-0.0	0.2	-0.2	-0.6	0.7
Distance traveled before self-admin	0.3	0.3	0.6	0.8	0.8	-0.6	0.4	0.6	0.2
Distance traveled after self-admin	0.2	0.2	0.4	0.6	0.6	-0.4	0.1	0.5	-0.1
Extensor digitorum longus weight	5.6	22.0	34.3	5.9	5.9	-5.1	5.0	3.4	-0.8
Bone: elastic displacement	0.8	0.9	2.1	-1.2	-1.2	0.4	-0.5	0.4	-1.4
Bone: elastic work	1.1	1.4	2.3	0.9	0.9	-1.4	1.2	1.3	-1.5
Bone: endosteal estimation	1.6	3.5	6.4	-1.3	-1.3	2.2	-1.5	-2.0	2.5
Bone: endosteal perimeter	2.2	4.5	7.4	-1.5	-1.5	2.5	-2.0	-2.3	2.7
Epididymis fat weight	2.8	6.5	8.7	-2.7	-2.7	3.0	-2.7	-2.3	1.8
Delta time in closed arm before/after self-admin	0.2	0.2	0.7	0.1	0.1	-0.4	0.8	-0.1	-0.7
Delta time in open arm before/after self-admin	0.1	0.1	0.5	0.2	0.2	-0.1	-0.4	0.7	-0.1
Diff in mean of infusions in LGA sessions	0.5	0.6	1.0	0.7	0.7	-0.8	0.5	1.0	-0.8
Delay discount exponential model param	0.2	0.2	0.8	0.3	0.3	-0.1	-0.2	0.9	-0.6
Extinction: sum of active levers before priming	3.4	3.3	5.8	2.4	2.4	-1.9	1.9	1.0	0.3
Active lever presses in extinction session 6	2.4	2.4	4.3	1.6	1.6	-1.5	1.2	2.1	-1.0
Bone: final force	1.9	3.1	5.7	2.4	2.4	-1.8	1.8	1.0	0.0
Bone: final moment	1.7	2.7	5.0	2.2	2.2	-1.7	1.7	0.9	0.0
Food consumed during 24 hour testing period	0.3	0.3	1.1	0.2	0.2	-0.3	-0.3	1.0	-0.8
Glucose	2.7	4.0	5.1	-1.8	-1.8	2.2	-1.8	-2.3	2.1
Heart weight	3.1	4.3	6.4	-2.5	-2.5	2.3	-1.9	-1.9	1.0
Delay discount hyperbolic model param	0.2	0.2	0.7	0.2	0.2	-0.1	-0.2	0.8	-0.5
Intermittent access intake day 1-15 change	0.6	0.6	1.4	-0.8	-0.8	0.8	-1.2	0.4	-0.4
Intermittent access intake escalation	0.5	0.5	1.2	-0.8	-0.8	0.8	-1.1	0.0	-0.1
Intermittent access intake escalation 2	0.3	0.3	0.5	-0.3	-0.3	0.2	-0.7	0.6	-0.6
Intermitt. access day 1 inactive lever presses	2.2	2.3	3.5	-1.7	-1.7	1.7	-1.9	-1.2	0.7
Intermitt. access day 15 inactive lever presses	2.6	2.8	5.1	-1.8	-1.8	2.0	-2.3	-1.0	0.8
Intermitt. access escalation Index	3.7	3.3	5.5	-2.0	-2.0	1.8	-1.4	-2.3	1.3
Intermittent access day 1 total infusions	7.8	9.0	11.5	-2.7	-2.7	3.4	-2.7	-3.4	3.0
Intermittent access day 15 total infusions	8.7	9.7	13.8	-3.3	-3.3	3.7	-3.6	-2.5	2.0
Intermittent access terminal intake (last 3 days)	6.9	7.5	11.0	-2.7	-2.7	3.3	-3.1	-2.3	2.2
Intermittent access total infusions	6.6	7.3	10.0	-2.6	-2.6	3.2	-2.7	-2.7	2.5
Intermittent access day 1 locomotion	5.8	6.1	9.0	-2.2	-2.2	2.7	-1.9	-3.0	2.6
Intermittent access day 15 total locomotion	5.6	6.0	8.2	-2.5	-2.5	2.9	-2.8	-2.1	1.7
Intermittent access total locomotion	8.9	10.1	13.6	-2.9	-2.9	3.7	-3.1	-3.3	3.1
Intermittent access standard deviation	1.1	1.2	2.1	-1.3	-1.3	1.2	-1.4	-0.5	0.0
Left kidney weight	0.6	1.7	2.9	-1.3	-1.3	1.5	-1.7	-0.9	0.8
Right kidney weight	0.2	0.5	1.4	-0.5	-0.5	0.8	-1.2	0.5	0.2
Cocaine induced anxiety	0.0	0.0	0.1	0.0	0.0	0.1	-0.2	0.3	0.0
Post-drug Anxiety	1.4	1.6	3.8	1.3	1.3	-1.1	0.9	1.9	-0.7
Baseline Anxiety	2.7	2.8	3.3	1.8	1.8	-1.8	1.7	1.8	-1.1
Tail length	1.2	3.6	6.6	1.4	1.4	-2.1	1.5	2.1	-2.6
Length with tail	2.3	8.3	10.5	3.0	3.0	-3.1	2.5	3.2	-2.3
Length without tail	2.2	4.8	6.6	2.5	2.5	-2.2	1.9	2.6	-1.0
Times rat made contact with spout	0.4	0.5	1.0	0.7	0.7	-1.0	1.0	0.0	-0.4
Lifetime Intake	5.8	6.6	8.8	-2.4	-2.4	3.0	-2.4	-2.7	2.5
Liver weight, left	0.0	0.1	0.1	-0.2	-0.2	0.4	-0.1	0.0	0.3
Liver weight, right	0.0	0.1	0.1	-0.3	-0.3	0.3	0.2	-0.2	-0.0
Locomotor activity	1.1	1.7	3.4	-1.9	-1.9	1.1	-1.1	-0.3	-1.1
Locomotor testing distance	1.6	2.6	5.5	-2.3	-2.3	1.2	-1.0	-0.4	-1.4
Locomotor testing rearing	1.4	2.2	4.6	-2.1	-2.1	1.2	-1.1	-1.0	-0.8
Locomotion in novel chamber	4.5	5.6	8.2	-2.6	-2.6	2.8	-2.9	-1.6	1.1
Locomotion in novel chamber post-restriction	2.6	3.2	4.4	-2.0	-2.0	2.1	-2.0	-1.3	0.8
Fecal boli incidents, locomotor time 1	0.2	0.2	0.4	0.0	0.0	0.3	-0.6	0.5	0.6
Change in fecal boli incidents, locomotor task	0.1	0.1	0.5	0.2	0.2	-0.1	0.7	-0.5	0.1
Time >=10cm from walls, locomotor time 1	2.4	2.4	5.7	-0.8	-0.8	1.8	-1.3	-1.7	2.4
Bouts of movement, locomotor time 1	1.5	1.7	2.8	1.3	1.3	-1.7	1.0	1.3	-1.0
Total resting periods, locomotor time 1	0.9	1.0	1.7	1.1	1.1	-1.3	0.7	1.0	-0.6
Rest time, locomotor task time 1	1.0	1.1	1.8	-1.3	-1.3	1.1	-1.2	-0.3	-0.2
Distance moved, locomotor task time 1	0.2	0.2	0.8	0.3	0.3	0.0	0.3	-0.7	0.9
Vertical activity count, locomotor time 1	1.1	1.1	1.6	-1.3	-1.3	1.2	-1.2	-0.8	0.4
Time >=10cm from walls, locomotor time 2	0.1	0.1	0.2	0.1	0.1	0.0	-0.2	-0.1	0.5
Bouts of movement, locomotor time 2	0.6	0.6	0.9	0.9	0.9	-0.9	0.6	0.7	-0.3
Total resting periods, locomotor time 2	0.3	0.3	0.5	0.7	0.7	-0.6	0.4	0.4	-0.0
Rest time, locomotor task time 2	2.2	2.5	3.6	-1.9	-1.9	1.8	-1.5	-1.3	0.8
Distance moved, locomotor task time 2	1.0	1.2	1.7	1.2	1.2	-1.3	1.1	1.0	-0.7
Vertical activity count, locomotor time 2	0.6	0.6	2.5	0.0	0.0	-0.5	0.3	1.0	-1.6
Light reinforcement 1	0.1	0.2	0.4	-0.5	-0.5	0.1	-0.3	0.2	-0.6
Light reinforcement 2	1.0	1.4	3.1	-1.2	-1.2	1.4	-1.7	-0.2	0.5
Bone: marrow area	1.7	3.7	6.6	-1.4	-1.4	2.2	-1.5	-2.1	2.6
Bone: maximum diameter	0.1	0.2	0.5	0.5	0.5	0.1	-0.2	0.7	0.4
Bone: maximum force	1.9	3.3	6.5	2.6	2.6	-1.5	1.6	0.5	1.2
Bone: maximum moment	1.6	2.8	5.5	2.3	2.3	-1.3	1.5	0.5	1.1
Mean time between licks in bursts	1.1	1.5	3.6	1.0	1.0	-1.3	1.9	0.7	-1.3
Mean num. licks in bursts	0.2	0.2	0.5	-0.6	-0.6	0.1	-0.0	-0.7	-0.2
Cd content in liver	1.1	1.2	2.9	-1.2	-1.2	1.2	-1.7	-0.1	-0.1
Co content in liver	0.9	1.0	2.4	-1.3	-1.3	0.3	-0.6	-0.1	-1.5
Cu content in liver	0.2	0.2	0.3	0.5	0.5	-0.5	0.4	0.2	0.3
Fe content in liver	0.2	0.2	0.8	0.3	0.3	-0.2	0.1	0.9	-0.2
K content in liver	1.0	1.0	1.6	1.3	1.3	-0.7	1.1	0.0	1.0
Mg content in liver	0.7	0.8	2.9	0.2	0.2	0.2	0.0	-1.2	1.7
Mn content in liver	1.8	2.0	3.3	1.8	1.8	-1.4	1.1	1.5	-0.2
Na content in liver	1.0	1.0	1.6	1.2	1.2	-1.0	0.9	1.3	-0.5
Rb content in liver	1.7	2.1	3.2	-1.5	-1.5	1.4	-1.3	-1.8	1.2
Se content in liver	0.2	0.3	0.9	-0.1	-0.1	0.5	-0.9	0.0	0.8
Sr content in liver	3.9	3.6	4.8	1.9	1.9	-2.0	1.6	2.2	-1.6
Zn content in liver	0.8	0.8	1.4	1.2	1.2	-1.1	0.8	0.6	0.1
Bone: minimum diameter	1.9	3.5	7.1	-1.2	-1.2	1.9	-1.5	-2.2	2.7
Time in familiar zone, hab. session 1	0.5	0.4	0.7	-0.5	-0.5	0.7	-0.5	-0.8	0.8
Time in novel zone, hab. session 1	0.3	0.2	1.1	-0.4	-0.4	-0.1	0.1	0.3	-1.0
Total zone transitions, hab. session 1	0.4	0.5	0.9	1.0	1.0	-0.9	0.7	0.2	0.1
Total locomotion distance, hab. session 1	0.5	0.8	1.4	-0.7	-0.7	0.9	-0.7	-1.0	1.2
Locomotion velocity, hab. session 1	0.2	0.2	0.9	-0.2	-0.2	0.4	-0.2	-0.6	0.9
Time in familiar zone, hab. session 2	0.2	0.2	1.0	-0.0	-0.0	-0.3	0.6	0.3	-1.0
Time in novel zone, hab. session 2	0.1	0.1	0.6	0.2	0.2	-0.1	0.0	-0.4	0.8
Total zone transitions, hab. session 2	1.0	1.3	1.7	1.3	1.3	-0.9	1.3	-0.8	1.3
Total locomotion distance, hab. session 2	0.6	0.8	2.6	-0.1	-0.1	0.5	0.1	-1.5	1.6
Locomotion velocity, hab. session 2	0.8	1.1	3.5	-0.3	-0.3	0.8	-0.2	-1.6	1.9
Novel to familiar place preference ratio	0.6	0.6	1.3	1.2	1.2	-0.7	0.3	0.5	0.5
Novelty place preference	0.3	0.3	0.5	0.7	0.7	-0.4	-0.0	0.3	0.6
Time in novel zone, NPP test	0.2	0.2	0.4	0.6	0.6	-0.3	0.0	0.2	0.5
Total zone transitions, NPP test	1.4	2.0	3.4	1.9	1.9	-1.5	1.6	0.2	0.4
Total locomotion distance, NPP test	0.2	0.3	1.0	0.2	0.2	0.1	0.2	-0.7	1.0
Locomotion velocity, NPP test	0.2	0.2	0.9	0.3	0.3	-0.0	0.2	-0.6	1.0
Intraocular pressure	0.7	1.0	2.5	-1.1	-1.1	1.0	-1.6	0.5	-0.4
Delta distance traveled before/after self-admin	0.0	0.0	0.2	-0.0	-0.0	-0.0	0.1	0.1	-0.5
Delta ambulatory time before/after self-admin	0.1	0.1	0.4	0.1	0.1	-0.2	0.3	0.2	-0.7
Parametrial fat weight	3.0	5.8	7.6	-2.1	-2.1	2.8	-2.3	-2.6	2.6
Pavlov. Cond. lever latency	0.2	0.2	0.3	-0.6	-0.6	0.3	-0.3	-0.3	-0.6
Pavlov. Cond. magazine entry latency	0.3	0.3	1.4	0.4	0.4	-0.1	0.1	-0.6	1.2
Pavlov. Cond. change in total contacts	0.2	0.2	1.1	0.2	0.2	0.2	-0.5	-0.0	1.0
Pavlov. Cond. index score	0.1	0.1	0.2	0.4	0.4	-0.3	0.0	0.4	0.4
Pavlov. Cond. latency score	0.1	0.1	0.3	0.3	0.3	-0.1	0.0	0.1	0.5
Pavlov. Cond. lever contacts	0.0	0.0	0.2	0.1	0.1	0.0	-0.0	0.1	0.4
Pavlov. Cond. magazine entry number	0.2	0.2	0.5	-0.6	-0.6	0.5	-0.1	-0.7	0.0
Pavlov. Cond. intertrial magazine entries	0.4	0.5	1.4	-0.8	-0.8	0.7	-1.2	0.1	-0.2
Pavlov. Cond. lever-magazine prob. diff.	0.2	0.2	0.4	0.6	0.6	-0.5	0.3	0.5	0.4
Pavlov. Cond. response bias	0.1	0.1	0.3	0.3	0.3	-0.2	-0.1	0.5	0.1
Pavlov. Cond. lever latency	0.2	0.3	0.7	-0.8	-0.8	0.4	-0.2	-0.4	-0.4
Pavlov. Cond. magazine entry latency	2.5	2.9	4.5	2.1	2.1	-1.8	2.0	1.1	0.1
Pavlov. Cond. change in total contacts	1.0	1.3	2.7	1.6	1.6	-1.0	0.6	0.8	0.8
Pavlov. Cond. index score	1.4	1.8	3.4	1.8	1.8	-1.3	1.2	0.9	0.4
Pavlov. Cond. latency score	1.1	1.4	2.6	1.6	1.6	-1.0	1.1	0.8	0.5
Pavlov. Cond. lever contacts	0.4	0.5	0.9	0.9	0.9	-0.6	0.3	0.9	-0.3
Pavlov. Cond. magazine entry number	4.6	5.6	8.9	-3.0	-3.0	2.6	-2.5	-1.7	0.1
Pavlov. Cond. intertrial magazine entries	1.0	1.3	1.8	-1.4	-1.4	1.3	-1.1	-0.9	0.4
Pavlov. Cond. lever-magazine prob. diff.	1.8	2.3	4.2	2.0	2.0	-1.5	1.4	1.0	0.3
Pavlov. Cond. response bias	1.2	1.7	2.8	1.7	1.7	-1.3	1.1	1.2	-0.1
Time in closed arm before self-admin	0.1	0.1	0.3	0.1	0.1	0.2	-0.2	0.1	0.6
Time in closed arm after self-admin	0.0	0.0	0.1	-0.0	-0.0	0.2	0.1	-0.4	0.3
Time in open arm before self-admin	0.4	0.5	1.1	-0.8	-0.8	0.1	0.2	-1.1	-0.5
Time in open arm after self-admin	0.2	0.2	0.8	-0.5	-0.5	-0.1	-0.3	0.2	-0.9
Bone: periosteal estimation	0.3	0.6	2.2	-0.2	-0.2	0.9	-0.7	-0.3	1.5
Bone: periosteal perimeter	0.1	0.2	0.9	0.3	0.3	0.3	-0.2	-0.1	1.0
Bone: post-yield work	2.9	3.9	16.7	0.7	0.7	1.0	-0.4	-2.1	4.1
Progressive ratio test 1 active lever presses	3.1	3.3	4.2	-2.0	-2.0	2.0	-2.0	-1.6	0.8
Progressive ratio test 1 breakpoint	2.7	2.8	3.7	-1.9	-1.9	1.8	-1.9	-1.4	0.6
Progressive ratio test 1 inactive lever presses	1.3	1.4	1.8	-1.3	-1.3	1.2	-1.2	-1.3	0.5
Progressive ratio test 2 active lever presses	4.9	5.2	7.2	-2.4	-2.4	2.7	-2.7	-1.9	1.4
Progressive ratio test 2 breakpoint	5.3	5.9	8.6	-2.7	-2.7	2.8	-2.9	-1.8	0.9
Progressive ratio test 2 inactive lever presses	9.2	10.6	14.2	-3.5	-3.5	3.7	-3.8	-2.7	2.0
Incentive Sensitization - Responses	0.7	0.7	1.1	-0.7	-0.7	1.0	-1.1	-0.8	0.8
Incentive Sensitization - Breakpoint	1.0	1.0	1.6	-0.9	-0.9	1.2	-1.2	-0.8	0.8
Sum of active levers in priming session hrs 5-6	2.1	2.0	5.6	1.4	1.4	-1.1	0.4	2.4	-1.2
Progressive ratio	1.4	1.6	2.5	1.5	1.5	-0.9	1.2	-0.4	1.6
Food seeking constrained by brief footshock	0.3	0.4	0.6	0.5	0.5	-0.6	0.8	0.5	-0.7
Seeking ratio, punishment vs. effort	1.0	1.3	2.4	-1.4	-1.4	0.7	-0.8	0.1	-1.5
Retroperitoneal fat weight	5.3	17.3	23.0	-4.5	-4.5	4.8	-4.7	-3.4	2.6
Reaction time number correct	0.4	0.6	1.0	0.6	0.6	-0.8	0.8	1.0	-1.0
Reaction time mean minus median	2.2	2.9	4.9	2.2	2.2	-1.6	1.5	1.6	0.2
Reaction time mean minus median AUC	1.4	1.8	2.8	1.6	1.6	-1.4	1.1	1.7	-0.4
Reaction time num false alarms	0.1	0.1	0.4	-0.4	-0.4	0.1	-0.0	0.1	-0.7
Reaction time num false alarms AUC	0.2	0.3	0.6	0.2	0.2	-0.5	0.6	0.5	-0.8
Reaction time trials correct on left	0.4	0.6	1.0	0.6	0.6	-0.8	0.8	1.0	-1.0
Reaction time trials on left	0.6	0.8	1.2	0.7	0.7	-0.9	0.8	1.1	-1.1
Reaction time mean	0.1	0.1	0.2	0.4	0.4	-0.1	-0.1	0.4	0.3
Reaction time mean AUC	0.1	0.1	0.3	0.4	0.4	0.0	-0.2	0.3	0.5
Median of all reaction times	0.1	0.1	0.3	0.0	0.0	0.3	-0.5	-0.1	0.5
Reaction time omissions	1.0	1.4	1.9	1.3	1.3	-1.4	1.2	1.3	-0.3
Reaction time false alarm rate	0.1	0.1	0.2	-0.4	-0.4	0.2	-0.0	-0.1	-0.2
Reaction time premature initiation rate	3.3	4.4	6.7	1.9	1.9	-2.4	2.6	1.8	-1.8
Reaction time premature initiations	5.1	7.2	9.4	2.4	2.4	-3.1	3.1	2.6	-2.5
Std. dev. reaction times	0.7	1.0	1.6	1.3	1.3	-0.9	0.7	1.2	0.0
Reaction time trials completed	0.6	0.8	1.2	0.7	0.7	-0.9	0.8	1.1	-1.1
Reaction time trials AUC	0.4	0.5	0.9	0.5	0.5	-0.7	0.7	0.9	-1.0
Run reversals in cocaine runway, females	0.7	0.7	1.3	0.5	0.5	-0.3	1.1	-1.1	1.1
Run reversals in cocaine runway, males	0.5	0.5	1.6	-0.5	-0.5	0.2	-0.4	0.9	-1.3
Latency to leave start box in cocaine runway	0.5	0.5	1.7	-0.2	-0.2	0.6	-0.3	-1.0	1.3
Latency to leave start box in cocaine runway, F	0.2	0.2	0.7	-0.1	-0.1	0.1	-0.1	-0.7	0.8
Latency to leave start box in cocaine runway, M	0.1	0.1	0.3	0.0	0.0	0.4	-0.1	-0.1	0.5
Std. dev. time between licks in bursts	0.3	0.3	1.1	-0.1	-0.1	-0.3	0.8	0.2	-1.0
Total sessions with >9 infusions	2.4	2.7	3.9	-1.5	-1.5	1.9	-1.3	-2.0	1.6
Short access day 1 total inactive lever presses	3.6	4.0	5.3	-2.2	-2.2	2.3	-2.1	-1.8	1.2
Short access day 10 total inactive lever presses	2.7	3.0	4.5	-2.1	-2.1	1.8	-1.8	-1.5	0.3
Short access day 1 total infusions	4.5	4.8	8.1	-1.9	-1.9	2.3	-1.7	-2.8	2.3
Short access day 10 total infusions	4.1	4.6	8.5	-1.4	-1.4	2.2	-1.4	-2.8	2.9
Short access total infusions	2.7	3.1	5.4	-1.4	-1.4	1.9	-1.2	-2.3	2.1
Short access day 1 locomotion	3.7	3.9	6.0	-1.8	-1.8	2.2	-1.6	-2.5	2.0
Short access day 10 total locomotion	2.9	3.3	5.8	-1.5	-1.5	1.9	-1.4	-2.4	2.0
Short access total locomotion	2.6	2.7	5.2	-1.4	-1.4	1.7	-1.1	-2.3	1.8
One hour access (0.3 mA shock)	10.0	11.7	15.3	-3.9	-3.9	3.9	-3.9	-2.7	1.5
Compulsive drug intake	3.6	3.6	5.7	1.7	1.7	-2.4	2.1	1.5	-1.9
One hour access (shock baseline)	9.6	11.1	16.1	-3.6	-3.6	4.0	-4.0	-2.4	1.9
Social response proportion	0.8	0.8	1.3	1.1	1.1	-0.9	1.1	0.6	-0.1
Social responses	0.4	0.5	0.7	0.6	0.6	-0.7	0.7	0.7	-0.8
Social time	0.5	0.7	1.0	0.7	0.7	-0.9	0.9	0.8	-1.0
Soleus weight	3.5	10.3	13.8	-3.7	-3.7	3.5	-3.7	-2.5	1.2
Bone: stiffness	1.6	2.5	5.0	2.2	2.2	-1.3	1.3	0.2	1.2
Tibialis anterior weight	9.2	31.3	42.7	6.5	6.5	-6.0	5.5	5.5	-2.5
Time to tail flick, vehicle, before self-admin	0.2	0.3	0.5	0.6	0.6	-0.3	0.5	-0.1	0.7
Time to tail flick, vehicle, after self-admin	0.9	1.0	2.6	1.1	1.1	-0.9	1.6	-0.1	0.4
Time to tail flick, test, before self-admin	1.6	1.5	3.6	-0.9	-0.9	1.2	-0.5	-1.9	1.5
Time to tail flick, test, after self-admin	0.1	0.1	0.2	0.1	0.1	-0.2	0.2	0.3	-0.4
Delta time to tail flick, vehicle, before/after SA	0.4	0.4	0.9	0.6	0.6	-0.6	1.0	-0.1	0.1
Delta time to tail flick, test, before/after SA	3.0	2.7	5.7	1.1	1.1	-1.6	0.9	2.4	-2.1
Tibia length	0.8	2.3	5.3	1.8	1.8	-1.2	0.7	2.3	-0.4
Ambulatory time before self-admin	0.2	0.2	0.5	0.7	0.7	-0.2	0.0	0.6	0.4
Ambulatory time after self-admin	0.3	0.3	0.8	-0.0	-0.0	0.5	-0.7	-0.5	0.9
Bone: tissue strength	0.0	0.0	0.1	0.2	0.2	0.0	-0.0	-0.2	0.3
Total heroin consumption	4.8	5.7	8.1	2.8	2.8	-2.7	2.6	1.9	-0.7
Bone: trabecular number	0.4	0.6	2.0	0.8	0.8	-0.0	-0.1	-0.4	1.4
Bone: trabecular spacing	0.1	0.2	0.3	-0.5	-0.5	0.1	0.3	-0.3	-0.6
Bone: trabecular thickness	1.0	1.2	1.6	-0.8	-0.8	1.1	-1.2	-1.2	1.3
Bone: trabecular tissue density	2.5	3.6	5.5	-2.3	-2.3	2.1	-2.1	-1.1	0.3
Water consumed over 24 hours	0.9	1.1	2.0	1.0	1.0	-1.4	0.9	0.9	-1.1
Number of responses in last shaping day	0.9	1.0	1.8	-1.3	-1.3	0.9	-1.0	-0.5	-0.3