Esrra

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Brain	isoform ratio	NM_001008511.2	0.04	0.02	8.9e-04	0.03	0.02	0.02	0.03	6.4e-04	3.6e-03	4.9e-03	1.7e-03
2	Brain	isoform ratio	XM_039108523.1	0.04	0.02	4.2e-04	0.04	0.03	0.03	0.04	2.0e-04	5.7e-04	4.9e-04	3.3e-04
3	Liver	gene expression	Esrra	0.03	0.02	1.0e-02	0	0	-0	0	1.7e-01	9.4e-02	7.0e-01	3.2e-01

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3
Bone: apparent density	0.1	0.1	0.1	0.4	-0.4	-0.2
Area under the delay curve	0.1	0.1	0.2	0.2	-0.2	-0.4
BMI with tail	2.2	7.2	8.4	2.9	-2.9	-2.2
BMI without tail	2.8	5.9	6.8	2.6	-2.6	-2.0
Body weight	3.3	13.7	15.0	3.9	-3.9	-3.4
Weight adjusted by age	1.5	1.7	2.1	1.5	-1.5	-1.0
Bone surface	1.6	2.8	3.8	2.0	-2.0	-0.9
Bone volume	0.2	0.3	0.5	0.7	-0.7	0.1
Breakpoint value in progressive ratio session	2.0	2.2	2.8	1.7	-1.7	-1.0
Number of licking bursts	0.2	0.2	0.3	0.6	-0.6	-0.2
Context. condit. distance diff. score	0.5	0.6	0.7	-0.8	0.8	0.7
Locomotion velocity, session 1	0.2	0.3	0.4	0.4	-0.4	-0.6
Locomotion distance, session 1	0.4	0.5	0.7	0.6	-0.6	-0.8
Locomotion velocity, session 2	2.3	2.7	2.8	1.7	-1.7	-1.5
Locomotion distance, session 2	0.6	0.8	1.3	0.7	-0.7	-1.1
Locomotion velocity, session 3	0.2	0.2	0.3	-0.5	0.5	0.4
Locomotion distance, session 3	0.0	0.0	0.0	-0.1	0.1	-0.0
Stereotopy head waving bouts, day 3	0.3	0.4	0.4	-0.7	0.7	0.4
Stereotopy head waving duration, day 3	0.7	0.8	0.9	-0.9	0.9	0.8
Locomotion velocity, session 7	0.6	0.7	0.7	-0.8	0.8	0.8
Locomotion distance, session 7	0.1	0.1	0.1	-0.3	0.3	-0.3
Stereotopy head waving bouts, day 7	0.3	0.4	1.1	-0.1	0.1	1.0
Stereotopy head waving duration, day 7	0.7	0.9	1.3	1.1	-1.1	-0.2
Locomotion velocity, session 8	1.8	2.1	2.2	1.4	-1.4	-1.5
Locomotion distance, session 8	0.0	0.0	0.1	0.0	-0.0	0.3
Degree of sensitization distance	0.0	0.0	0.0	-0.1	0.1	-0.0
Degree of sensitization stereotypy	0.3	0.3	0.4	0.6	-0.6	0.4
Conditioned locomotion	1.8	2.1	2.3	1.5	-1.5	-1.2
Cocaine response after cond. corrected	0.9	1.0	1.5	-1.2	1.2	0.3
Cocaine response after cond. not corrected	0.8	0.8	1.2	-1.1	1.1	0.2
Cocaine response before conditioning	0.1	0.1	0.2	0.4	-0.4	-0.3
Saline control response	4.6	6.0	6.4	2.5	-2.5	-2.3
Bone: connectivity density	1.0	1.6	1.8	1.3	-1.3	-1.1
Bone: cortical apparent density	0.4	0.5	0.5	0.7	-0.7	-0.7
Bone: cortical area	0.4	0.5	0.8	0.9	-0.9	-0.2
Bone: cortical porosity	0.1	0.2	0.2	0.5	-0.5	-0.1
Bone: cortical porosity	0.7	0.8	1.0	1.0	-1.0	-0.6
Bone: cortical thickness	3.2	5.2	5.4	2.3	-2.3	-2.2
Bone: cortical thickness	1.0	1.2	2.4	0.8	-0.8	-1.5
Bone: cortical tissue density	0.5	0.6	0.6	0.8	-0.8	-0.8
Condit. Reinf. active minus inactive responses	0.7	0.8	1.0	1.0	-1.0	-0.4
Condit. Reinf. active-inactive response ratio	0.3	0.3	0.5	0.7	-0.7	-0.2
Condit. Reinf. active responses	0.1	0.1	0.2	0.4	-0.4	0.1
Condit. Reinf. inactive responses	0.3	0.4	0.5	-0.6	0.6	0.7
Incentive salience index mean	0.7	0.9	1.2	1.1	-1.1	-0.5
Condit. Reinf. lever presses	0.2	0.3	0.4	0.6	-0.6	-0.2
Condit. Reinf. active minus inactive responses	0.5	0.6	1.4	-0.5	0.5	1.2
Condit. Reinf. active-inactive response ratio	2.2	2.3	4.2	-1.1	1.1	2.0
Condit. Reinf. active responses	0.1	0.1	0.1	0.3	-0.3	0.3
Condit. Reinf. inactive responses	1.2	1.5	1.5	1.2	-1.2	-1.2
Condit. Reinf. lever presses	0.7	1.0	1.5	1.2	-1.2	-0.3
Condit. Reinf. lever reinforcers received	0.1	0.2	0.2	0.5	-0.5	0.2
Conditioned reinforcement - actives	1.3	1.3	1.9	-1.0	1.0	1.4
Conditioned reinforcement - inactives	7.2	8.1	9.1	-2.8	2.8	3.0
Conditioned locomotion	11.0	13.2	14.5	-3.8	3.8	3.3
Patch foraging indifference point 0 sec	0.0	0.0	0.1	-0.0	0.0	0.3
Patch foraging indifference point AUC	3.1	3.6	4.8	2.2	-2.2	-1.1
Delay disc. indifference point, 0s delay	0.1	0.1	0.2	-0.0	0.0	-0.4
Delay disc. indifference point, 16s delay	0.8	0.8	1.0	-0.8	0.8	1.0
Delay disc. indifference point, 2s delay	0.0	0.0	0.0	-0.2	0.2	0.1
Delay disc. indifference point, 24s delay	0.2	0.2	0.5	0.3	-0.3	-0.7
Delay disc. indifference point, 4s delay	0.4	0.4	0.7	0.6	-0.6	-0.8
Delay disc. indifference point, 8s delay	0.2	0.2	0.5	0.3	-0.3	-0.7
Indifference point function ln k	5.2	7.3	9.7	-3.1	3.1	1.6
Indifference point function log k	5.2	7.3	9.7	-3.1	3.1	1.6
Patch foraging total patch changes 0 sec	0.0	0.0	0.0	0.1	-0.1	-0.0
Patch foraging total patch changes 12 sec	3.9	5.0	5.9	2.4	-2.4	-1.8
Patch foraging total patch changes 18 sec	0.7	0.9	1.3	1.1	-1.1	-0.4
Patch foraging total patch changes 24 sec	3.2	4.0	4.9	2.2	-2.2	-1.5
Patch foraging total patch changes 6 sec	1.1	1.7	2.0	1.4	-1.4	-1.1
Patch foraging time to switch 0 sec	0.5	0.8	1.0	1.0	-1.0	-0.5
Patch foraging water rate 0 sec	2.5	4.0	4.8	-2.2	2.2	1.6
Patch foraging water rate 12 sec	3.7	5.6	7.2	-2.7	2.7	1.5
Patch foraging water rate 18 sec	1.7	2.3	3.3	-1.8	1.8	0.7
Patch foraging water rate 24 sec	2.7	3.8	5.1	-2.3	2.3	1.1
Patch foraging water rate 6 sec	1.9	2.7	3.8	-2.0	2.0	0.7
Seeking ratio, delayed vs. immediate footshock	0.0	0.0	0.0	-0.1	0.1	0.1
Distance traveled before self-admin	0.2	0.2	0.3	0.5	-0.5	0.1
Distance traveled after self-admin	0.0	0.0	0.0	0.2	-0.2	0.1
Extensor digitorum longus weight	6.8	26.8	30.5	5.5	-5.5	-4.4
Bone: elastic displacement	0.3	0.4	0.5	-0.7	0.7	-0.1
Bone: elastic work	1.7	2.2	3.1	1.3	-1.3	-1.8
Bone: endosteal estimation	1.1	2.3	3.0	-1.4	1.4	1.7
Bone: endosteal perimeter	2.0	4.1	6.3	-1.7	1.7	2.5
Epididymis fat weight	2.5	5.7	5.9	-2.4	2.4	2.3
Delta time in closed arm before/after self-admin	0.5	0.5	1.6	-0.1	0.1	-1.2
Delta time in open arm before/after self-admin	0.3	0.3	0.4	0.6	-0.6	0.6
Diff in mean of infusions in LGA sessions	0.4	0.5	0.6	0.8	-0.8	-0.5
Delay discount exponential model param	0.1	0.1	0.2	-0.3	0.3	0.5
Extinction: sum of active levers before priming	4.6	4.6	5.8	2.4	-2.4	-1.5
Active lever presses in extinction session 6	1.5	1.5	2.0	1.4	-1.4	-0.6
Bone: final force	2.0	3.2	3.9	2.0	-2.0	-1.3
Bone: final moment	1.7	2.8	3.4	1.9	-1.9	-1.2
Food consumed during 24 hour testing period	0.0	0.0	0.1	0.1	-0.1	0.4
Glucose	2.9	4.4	5.2	-2.3	2.3	1.7
Heart weight	3.9	5.5	7.4	-2.7	2.7	1.3
Delay discount hyperbolic model param	0.2	0.2	0.2	-0.4	0.4	0.5
Intermittent access intake day 1-15 change	0.9	0.9	1.7	-0.7	0.7	1.3
Intermittent access intake escalation	0.8	0.8	1.5	-0.7	0.7	1.2
Intermittent access intake escalation 2	0.4	0.4	0.9	-0.4	0.4	1.0
Intermitt. access day 1 inactive lever presses	2.6	2.8	3.0	-1.6	1.6	1.7
Intermitt. access day 15 inactive lever presses	4.6	5.1	6.0	-2.1	2.1	2.5
Intermitt. access escalation Index	2.0	1.8	2.5	-1.6	1.6	0.6
Intermittent access day 1 total infusions	7.1	8.3	8.9	-3.0	3.0	2.7
Intermittent access day 15 total infusions	11.2	12.6	12.7	-3.5	3.5	3.6
Intermittent access terminal intake (last 3 days)	8.3	9.1	10.6	-2.9	2.9	3.2
Intermittent access total infusions	7.6	8.4	8.7	-2.9	2.9	2.9
Intermittent access day 1 locomotion	4.3	4.5	5.4	-2.3	2.3	1.6
Intermittent access day 15 total locomotion	6.9	7.4	7.5	-2.7	2.7	2.7
Intermittent access total locomotion	9.0	10.3	10.5	-3.2	3.2	3.2
Intermittent access standard deviation	1.7	1.8	2.3	-1.3	1.3	1.5
Left kidney weight	1.1	3.1	3.6	-1.9	1.9	1.4
Right kidney weight	0.5	1.4	2.1	-1.0	1.0	1.5
Cocaine induced anxiety	0.1	0.1	0.2	0.2	-0.2	0.4
Post-drug Anxiety	0.8	0.9	1.3	1.1	-1.1	-0.2
Baseline Anxiety	2.1	2.3	2.3	1.5	-1.5	-1.5
Tail length	1.5	4.6	4.7	2.2	-2.2	-2.1
Length with tail	1.9	6.9	7.1	2.7	-2.7	-2.6
Length without tail	0.8	1.7	1.9	1.2	-1.2	-1.4
Times rat made contact with spout	1.3	1.5	1.7	1.3	-1.3	-1.1
Lifetime Intake	6.2	7.0	7.4	-2.7	2.7	2.5
Liver weight, left	0.0	0.0	0.1	-0.0	0.0	0.3
Liver weight, right	0.1	0.2	0.2	0.5	-0.5	-0.5
Locomotor activity	0.7	1.2	1.7	-1.3	1.3	0.3
Locomotor testing distance	0.8	1.3	1.9	-1.4	1.4	0.1
Locomotor testing rearing	0.7	1.1	1.6	-1.3	1.3	0.4
Locomotion in novel chamber	5.9	7.3	8.8	-2.6	2.6	3.0
Locomotion in novel chamber post-restriction	3.4	4.1	4.2	-2.1	2.1	1.9
Fecal boli incidents, locomotor time 1	0.2	0.2	0.7	0.0	-0.0	0.8
Change in fecal boli incidents, locomotor task	0.4	0.3	0.9	0.2	-0.2	-1.0
Time >=10cm from walls, locomotor time 1	1.7	1.7	3.1	-1.0	1.0	1.8
Bouts of movement, locomotor time 1	0.8	0.9	1.1	1.0	-1.0	-0.7
Total resting periods, locomotor time 1	0.3	0.3	0.4	0.7	-0.7	-0.4
Rest time, locomotor task time 1	0.9	0.9	1.2	-0.9	0.9	1.1
Distance moved, locomotor task time 1	0.3	0.3	0.4	0.6	-0.6	-0.4
Vertical activity count, locomotor time 1	0.8	0.8	0.9	-0.9	0.9	0.9
Time >=10cm from walls, locomotor time 2	0.3	0.3	0.5	0.4	-0.4	0.7
Bouts of movement, locomotor time 2	0.2	0.2	0.3	0.5	-0.5	-0.5
Total resting periods, locomotor time 2	0.0	0.0	0.1	0.2	-0.2	-0.3
Rest time, locomotor task time 2	2.7	3.0	3.5	-1.9	1.9	1.5
Distance moved, locomotor task time 2	1.6	1.9	2.3	1.5	-1.5	-1.0
Vertical activity count, locomotor time 2	0.2	0.2	0.4	0.3	-0.3	-0.6
Light reinforcement 1	0.0	0.0	0.1	0.1	-0.1	0.3
Light reinforcement 2	3.0	4.1	5.4	-1.9	1.9	2.3
Bone: marrow area	1.1	2.3	2.9	-1.4	1.4	1.7
Bone: maximum diameter	0.1	0.2	0.6	0.3	-0.3	0.8
Bone: maximum force	1.5	2.5	3.4	1.9	-1.9	-0.9
Bone: maximum moment	1.3	2.2	3.0	1.7	-1.7	-0.8
Mean time between licks in bursts	1.3	1.8	3.6	1.0	-1.0	-1.9
Mean num. licks in bursts	0.0	0.0	0.0	-0.1	0.1	-0.2
Cd content in liver	0.9	1.0	2.3	-0.6	0.6	1.5
Co content in liver	0.1	0.1	0.1	-0.3	0.3	-0.2
Cu content in liver	0.2	0.3	0.3	0.6	-0.6	-0.4
Fe content in liver	0.1	0.2	0.3	0.5	-0.5	0.1
K content in liver	1.6	1.6	1.9	1.4	-1.4	-1.0
Mg content in liver	0.1	0.1	0.1	0.3	-0.3	-0.0
Mn content in liver	1.4	1.5	2.2	1.5	-1.5	-0.5
Na content in liver	0.9	0.9	1.3	1.1	-1.1	-0.4
Rb content in liver	1.1	1.4	1.6	-1.3	1.3	1.0
Se content in liver	0.6	0.8	1.9	-0.5	0.5	1.4
Sr content in liver	2.4	2.2	2.6	1.6	-1.6	-1.2
Zn content in liver	0.6	0.7	0.8	0.9	-0.9	-0.7
Bone: minimum diameter	0.9	1.7	2.5	-1.2	1.2	1.6
Time in familiar zone, hab. session 1	0.1	0.1	0.1	-0.3	0.3	0.3
Time in novel zone, hab. session 1	0.1	0.1	0.1	-0.3	0.3	-0.3
Total zone transitions, hab. session 1	1.1	1.5	2.1	1.5	-1.5	-0.6
Total locomotion distance, hab. session 1	0.1	0.2	0.5	-0.0	0.0	0.7
Locomotion velocity, hab. session 1	0.1	0.2	0.2	0.5	-0.5	0.3
Time in familiar zone, hab. session 2	0.5	0.6	1.3	0.4	-0.4	-1.2
Time in novel zone, hab. session 2	0.1	0.1	0.2	-0.1	0.1	0.5
Total zone transitions, hab. session 2	1.3	1.7	1.9	1.4	-1.4	-1.1
Total locomotion distance, hab. session 2	0.1	0.2	0.2	0.5	-0.5	-0.2
Locomotion velocity, hab. session 2	0.0	0.0	0.1	0.2	-0.2	0.2
Novel to familiar place preference ratio	0.0	0.0	0.0	0.2	-0.2	0.1
Novelty place preference	0.1	0.1	0.1	-0.2	0.2	0.4
Time in novel zone, NPP test	0.0	0.0	0.1	-0.2	0.2	0.3
Total zone transitions, NPP test	2.1	3.0	3.7	1.9	-1.9	-1.3
Total locomotion distance, NPP test	0.1	0.1	0.2	0.5	-0.5	-0.2
Locomotion velocity, NPP test	0.1	0.2	0.3	0.5	-0.5	-0.1
Intraocular pressure	1.8	2.5	3.0	-1.5	1.5	1.7
Delta distance traveled before/after self-admin	0.0	0.0	0.1	-0.0	0.0	-0.4
Delta ambulatory time before/after self-admin	0.1	0.2	0.3	0.2	-0.2	-0.6
Parametrial fat weight	1.9	3.6	3.8	-1.9	1.9	1.8
Pavlov. Cond. lever latency	0.2	0.3	0.3	-0.6	0.6	0.4
Pavlov. Cond. magazine entry latency	0.2	0.3	0.4	0.7	-0.7	-0.1
Pavlov. Cond. change in total contacts	0.3	0.3	0.5	-0.4	0.4	0.7
Pavlov. Cond. index score	0.1	0.2	0.3	0.5	-0.5	-0.1
Pavlov. Cond. latency score	0.1	0.1	0.2	0.5	-0.5	-0.1
Pavlov. Cond. lever contacts	0.1	0.1	0.1	0.3	-0.3	-0.3
Pavlov. Cond. magazine entry number	0.1	0.2	0.3	-0.5	0.5	-0.1
Pavlov. Cond. intertrial magazine entries	0.9	1.1	1.2	-1.1	1.1	1.0
Pavlov. Cond. lever-magazine prob. diff.	0.3	0.4	0.6	0.8	-0.8	-0.2
Pavlov. Cond. response bias	0.1	0.1	0.1	0.4	-0.4	0.1
Pavlov. Cond. lever latency	0.1	0.1	0.1	-0.4	0.4	-0.1
Pavlov. Cond. magazine entry latency	2.7	3.1	3.5	1.9	-1.9	-1.5
Pavlov. Cond. change in total contacts	0.3	0.5	0.6	0.8	-0.8	0.3
Pavlov. Cond. index score	0.7	0.9	1.3	1.1	-1.1	-0.5
Pavlov. Cond. latency score	0.6	0.7	1.0	1.0	-1.0	-0.4
Pavlov. Cond. lever contacts	0.0	0.1	0.1	0.3	-0.3	0.1
Pavlov. Cond. magazine entry number	3.7	4.6	5.6	-2.4	2.4	1.6
Pavlov. Cond. intertrial magazine entries	0.5	0.6	0.9	-0.7	0.7	1.0
Pavlov. Cond. lever-magazine prob. diff.	1.1	1.4	1.8	1.4	-1.4	-0.7
Pavlov. Cond. response bias	0.6	0.8	1.0	1.0	-1.0	-0.5
Time in closed arm before self-admin	0.1	0.1	0.3	0.2	-0.2	0.5
Time in closed arm after self-admin	0.1	0.1	0.1	-0.4	0.4	-0.2
Time in open arm before self-admin	0.3	0.4	0.9	-0.3	0.3	-0.9
Time in open arm after self-admin	0.0	0.0	0.0	0.0	-0.0	-0.1
Bone: periosteal estimation	0.2	0.4	1.2	-0.3	0.3	1.1
Bone: periosteal perimeter	0.1	0.2	0.5	0.1	-0.1	0.7
Bone: post-yield work	0.6	0.8	2.2	-0.3	0.3	1.5
Progressive ratio test 1 active lever presses	4.1	4.3	4.5	-2.1	2.1	2.0
Progressive ratio test 1 breakpoint	3.4	3.5	3.5	-1.9	1.9	1.9
Progressive ratio test 1 inactive lever presses	1.3	1.5	1.9	-1.4	1.4	0.7
Progressive ratio test 2 active lever presses	6.6	7.1	8.1	-2.6	2.6	2.9
Progressive ratio test 2 breakpoint	7.8	8.8	9.1	-2.9	2.9	3.0
Progressive ratio test 2 inactive lever presses	11.0	12.7	13.1	-3.5	3.5	3.6
Incentive Sensitization - Responses	1.0	1.1	1.7	-0.9	0.9	1.3
Incentive Sensitization - Breakpoint	1.4	1.4	2.3	-1.0	1.0	1.5
Sum of active levers in priming session hrs 5-6	0.3	0.3	0.3	0.6	-0.6	0.4
Progressive ratio	2.0	2.3	3.1	1.8	-1.8	-0.9
Food seeking constrained by brief footshock	0.4	0.5	1.1	0.4	-0.4	-1.1
Seeking ratio, punishment vs. effort	1.3	1.6	2.4	-1.6	1.6	0.1
Retroperitoneal fat weight	5.9	19.5	21.7	-4.7	4.7	3.9
Reaction time number correct	0.4	0.5	0.5	0.7	-0.7	-0.7
Reaction time mean minus median	1.6	2.1	3.0	1.7	-1.7	-0.6
Reaction time mean minus median AUC	1.3	1.6	2.3	1.5	-1.5	-0.6
Reaction time num false alarms	0.4	0.5	0.6	-0.7	0.7	-0.8
Reaction time num false alarms AUC	0.4	0.5	1.6	-0.0	0.0	-1.3
Reaction time trials correct on left	0.4	0.5	0.5	0.7	-0.7	-0.7
Reaction time trials on left	0.4	0.6	0.6	0.8	-0.8	-0.8
Reaction time mean	0.1	0.2	0.5	-0.1	0.1	0.7
Reaction time mean AUC	0.2	0.2	0.6	-0.1	0.1	0.8
Median of all reaction times	0.3	0.4	0.8	-0.5	0.5	0.9
Reaction time omissions	0.4	0.5	0.5	0.7	-0.7	-0.7
Reaction time false alarm rate	0.3	0.4	0.4	-0.6	0.6	-0.6
Reaction time premature initiation rate	4.3	5.7	7.1	2.3	-2.3	-2.7
Reaction time premature initiations	5.9	8.4	9.3	2.8	-2.8	-3.1
Std. dev. reaction times	0.2	0.3	0.4	0.7	-0.7	0.1
Reaction time trials completed	0.4	0.6	0.6	0.8	-0.8	-0.8
Reaction time trials AUC	0.3	0.4	0.5	0.6	-0.6	-0.7
Run reversals in cocaine runway, females	0.9	0.9	2.1	0.6	-0.6	-1.5
Run reversals in cocaine runway, males	0.2	0.2	0.2	0.5	-0.5	0.0
Latency to leave start box in cocaine runway	0.1	0.1	0.3	-0.1	0.1	0.5
Latency to leave start box in cocaine runway, F	0.0	0.0	0.1	0.1	-0.1	0.3
Latency to leave start box in cocaine runway, M	0.1	0.1	0.1	-0.2	0.2	0.3
Std. dev. time between licks in bursts	0.3	0.3	1.0	-0.1	0.1	-1.0
Total sessions with >9 infusions	2.0	2.2	2.5	-1.6	1.6	1.2
Short access day 1 total inactive lever presses	5.2	5.8	6.9	-2.6	2.6	1.9
Short access day 10 total inactive lever presses	2.7	3.0	4.0	-2.0	2.0	1.0
Short access day 1 total infusions	3.8	4.0	4.7	-2.2	2.2	1.6
Short access day 10 total infusions	2.9	3.2	3.6	-1.9	1.9	1.6
Short access total infusions	2.2	2.4	3.0	-1.7	1.7	1.2
Short access day 1 locomotion	2.8	3.0	3.7	-1.9	1.9	1.2
Short access day 10 total locomotion	1.9	2.1	2.5	-1.6	1.6	1.1
Short access total locomotion	1.9	1.9	2.5	-1.6	1.6	0.9
One hour access (0.3 mA shock)	12.5	14.6	15.4	-3.9	3.9	3.6
Compulsive drug intake	4.8	4.8	7.0	1.9	-1.9	-2.6
One hour access (shock baseline)	14.1	16.4	18.2	-3.9	3.9	4.3
Social response proportion	0.7	0.8	1.0	1.0	-1.0	-0.6
Social responses	1.0	1.2	1.5	1.2	-1.2	-0.8
Social time	0.7	1.0	1.1	1.0	-1.0	-0.9
Soleus weight	3.0	8.8	9.7	-3.1	3.1	2.6
Bone: stiffness	1.2	1.9	2.7	1.6	-1.6	-0.5
Tibialis anterior weight	9.8	33.6	39.3	6.3	-6.3	-4.7
Time to tail flick, vehicle, before self-admin	0.3	0.3	0.5	0.7	-0.7	-0.3
Time to tail flick, vehicle, after self-admin	3.7	3.9	3.9	2.0	-2.0	-2.0
Time to tail flick, test, before self-admin	0.3	0.3	0.4	-0.6	0.6	0.1
Time to tail flick, test, after self-admin	0.0	0.0	0.1	0.2	-0.2	-0.2
Delta time to tail flick, vehicle, before/after SA	1.4	1.4	1.6	1.1	-1.1	-1.3
Delta time to tail flick, test, before/after SA	0.7	0.6	0.8	0.9	-0.9	-0.5
Tibia length	0.2	0.6	0.9	0.9	-0.9	0.3
Ambulatory time before self-admin	0.2	0.2	0.3	0.3	-0.3	0.6
Ambulatory time after self-admin	0.5	0.5	1.1	-0.5	0.5	1.0
Bone: tissue strength	0.1	0.1	0.2	-0.3	0.3	0.5
Total heroin consumption	4.4	5.2	5.7	2.4	-2.4	-2.1
Bone: trabecular number	0.0	0.0	0.1	0.2	-0.2	0.2
Bone: trabecular spacing	0.1	0.1	0.2	0.0	-0.0	-0.5
Bone: trabecular thickness	1.1	1.3	1.4	-1.2	1.2	1.1
Bone: trabecular tissue density	3.1	4.4	4.7	-2.2	2.2	1.9
Water consumed over 24 hours	1.2	1.5	1.6	1.3	-1.3	-1.1
Number of responses in last shaping day	1.3	1.3	1.9	-1.4	1.4	0.4