Hub : Genes

Rnf111

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	PL	intron excision ratio	chr8_71144158_71179413	0.03	0.03	1.9e-03	0.01	0.01	0.01	0.01	1.2e-02	3.4e-02	3.4e-02	3.2e-02
2	Brain	gene expression	Rnf111	0.03	0.03	5.4e-04	0.03	0.03	0.03	0.03	8.6e-04	8.8e-04	1.0e-03	1.1e-03
3	pVTA	mRNA stability	Rnf111	0.06	0.05	6.8e-03	0.04	0.05	0.04	0.04	6.4e-03	4.5e-03	5.3e-03	6.4e-03
4	RMTg	mRNA stability	Rnf111	0.14	0.13	7.4e-03	0.12	0.08	0.09	0.09	5.1e-04	3.3e-03	2.4e-03	2.0e-03
5	Adipose	gene expression	Rnf111	0.03	0.03	1.1e-03	0.02	0.02	0.02	0.01	4.3e-03	4.9e-03	4.4e-03	7.1e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bone: apparent density	0.5	0.8	1.1	0.9	-0.8	-0.9	0.9	-1.0
Area under the delay curve	0.0	0.0	0.1	-0.4	-0.1	0.0	0.2	0.2
BMI with tail	5.6	18.0	21.4	-4.6	3.9	4.2	-4.1	4.4
BMI without tail	2.7	5.6	6.0	-2.3	2.5	2.3	-2.4	2.4
Body weight	4.6	19.2	20.5	-4.5	4.2	4.4	-4.5	4.3
Weight adjusted by age	6.4	7.3	9.2	-2.7	3.0	2.6	-2.4	2.6
Bone surface	0.1	0.1	0.2	-0.3	0.4	0.3	-0.3	0.1
Bone volume	0.0	0.0	0.0	0.0	0.1	-0.0	-0.0	-0.1
Breakpoint value in progressive ratio session	0.4	0.5	0.7	-0.6	0.7	0.7	-0.8	0.6
Number of licking bursts	2.2	2.6	3.5	1.9	-1.4	-1.6	1.6	-1.6
Context. condit. distance diff. score	1.1	1.3	1.5	1.1	-1.2	-1.1	1.1	-1.1
Locomotion velocity, session 1	1.4	1.5	2.3	-0.5	1.5	1.2	-1.5	1.1
Locomotion distance, session 1	0.3	0.4	0.8	0.9	-0.3	-0.6	0.4	-0.8
Locomotion velocity, session 2	0.1	0.2	0.3	-0.1	0.6	0.4	-0.5	0.2
Locomotion distance, session 2	0.1	0.2	0.5	0.1	0.7	0.3	-0.4	0.3
Locomotion velocity, session 3	0.1	0.1	0.3	0.5	0.0	-0.1	-0.1	-0.2
Locomotion distance, session 3	2.0	2.2	3.1	1.8	-1.5	-1.5	1.2	-1.5
Stereotopy head waving bouts, day 3	0.6	0.7	1.0	-1.0	0.8	0.9	-0.7	0.9
Stereotopy head waving duration, day 3	0.7	0.8	1.2	-1.1	0.9	0.9	-0.7	0.9
Locomotion velocity, session 7	1.7	1.9	3.0	1.7	-1.3	-1.4	1.2	-1.2
Locomotion distance, session 7	1.6	2.1	3.0	1.7	-1.5	-1.5	1.4	-1.1
Stereotopy head waving bouts, day 7	1.4	1.5	2.7	-1.6	1.0	1.2	-1.0	1.3
Stereotopy head waving duration, day 7	1.2	1.5	2.9	-1.7	0.9	1.2	-0.9	1.2
Locomotion velocity, session 8	0.3	0.4	0.6	0.2	0.7	0.5	-0.8	0.7
Locomotion distance, session 8	0.7	1.0	1.5	1.2	-0.8	-1.0	0.9	-1.0
Degree of sensitization distance	0.1	0.1	0.3	0.2	-0.5	-0.4	0.6	-0.1
Degree of sensitization stereotypy	0.9	1.0	1.7	-1.3	0.8	0.9	-0.8	1.0
Conditioned locomotion	0.1	0.1	0.1	0.3	-0.2	-0.3	0.3	-0.2
Cocaine response after cond. corrected	3.3	3.7	4.1	-1.8	2.0	1.9	-1.9	2.0
Cocaine response after cond. not corrected	1.8	2.0	2.2	-1.3	1.5	1.4	-1.4	1.5
Cocaine response before conditioning	1.2	1.4	1.7	1.1	-1.2	-1.2	1.2	-1.3
Saline control response	0.1	0.2	0.3	-0.1	-0.5	-0.3	0.5	-0.5
Bone: connectivity density	1.1	1.7	2.2	1.3	-1.1	-1.3	1.2	-1.5
Bone: cortical apparent density	0.5	0.7	0.7	0.8	-0.9	-0.8	0.8	-0.8
Bone: cortical area	0.0	0.0	0.1	0.3	-0.1	-0.0	-0.1	-0.2
Bone: cortical porosity	0.6	0.6	0.8	0.7	-0.9	-0.8	0.7	-0.9
Bone: cortical porosity	1.5	1.6	1.7	1.2	-1.3	-1.3	1.2	-1.3
Bone: cortical thickness	1.3	2.1	2.6	1.6	-1.4	-1.4	1.3	-1.5
Bone: cortical thickness	0.9	1.0	1.7	1.3	-0.8	-0.9	0.8	-1.1
Bone: cortical tissue density	0.5	0.6	0.7	0.8	-0.8	-0.8	0.7	-0.8
Condit. Reinf. active minus inactive responses	0.0	0.0	0.1	0.1	-0.0	-0.1	-0.1	-0.3
Condit. Reinf. active-inactive response ratio	0.6	0.7	0.9	0.8	-0.8	-0.8	0.8	-0.9
Condit. Reinf. active responses	0.4	0.5	0.8	-0.7	0.7	0.7	-0.9	0.5
Condit. Reinf. inactive responses	1.3	1.6	2.0	-1.1	1.2	1.2	-1.4	1.2
Incentive salience index mean	0.0	0.0	0.1	0.1	0.1	0.0	-0.2	-0.4
Condit. Reinf. lever presses	0.1	0.1	0.3	0.4	-0.1	-0.2	-0.1	-0.5
Condit. Reinf. active minus inactive responses	2.6	3.3	3.8	-1.7	1.9	1.9	-2.0	1.6
Condit. Reinf. active-inactive response ratio	0.9	1.0	1.1	-1.0	1.1	1.0	-0.9	0.9
Condit. Reinf. active responses	1.3	1.8	2.4	-1.2	1.5	1.4	-1.6	1.0
Condit. Reinf. inactive responses	0.1	0.1	0.2	0.4	0.1	-0.1	-0.2	-0.5
Condit. Reinf. lever presses	0.7	0.9	1.5	1.0	-0.8	-0.9	0.7	-1.2
Condit. Reinf. lever reinforcers received	0.7	1.0	1.4	-0.8	1.1	1.0	-1.2	0.7
Conditioned reinforcement - actives	0.3	0.3	0.6	-0.7	-0.3	0.1	0.3	0.8
Conditioned reinforcement - inactives	0.0	0.0	0.1	-0.0	-0.3	-0.0	-0.1	0.3
Conditioned locomotion	0.4	0.5	0.8	0.6	-0.7	-0.7	0.9	-0.4
Patch foraging indifference point 0 sec	0.2	0.4	0.7	-0.5	0.7	0.6	-0.9	0.3
Patch foraging indifference point AUC	0.1	0.1	0.3	0.2	0.4	0.2	-0.6	-0.1
Delay disc. indifference point, 0s delay	0.2	0.2	0.3	0.1	-0.5	-0.4	0.5	-0.4
Delay disc. indifference point, 16s delay	0.2	0.2	0.4	-0.2	-0.6	-0.3	0.5	-0.0
Delay disc. indifference point, 2s delay	0.0	0.0	0.1	-0.1	-0.2	-0.2	0.3	-0.0
Delay disc. indifference point, 24s delay	0.2	0.2	0.3	0.3	-0.6	-0.5	0.6	-0.4
Delay disc. indifference point, 4s delay	0.1	0.1	0.2	-0.1	-0.5	-0.3	0.5	-0.2
Delay disc. indifference point, 8s delay	0.1	0.1	0.2	-0.4	0.1	0.2	-0.1	0.5
Indifference point function ln k	0.3	0.4	0.6	-0.7	0.6	0.6	-0.4	0.7
Indifference point function log k	0.3	0.4	0.6	-0.7	0.6	0.6	-0.4	0.7
Patch foraging total patch changes 0 sec	0.3	0.5	1.0	-0.6	0.8	0.7	-1.0	0.4
Patch foraging total patch changes 12 sec	0.1	0.1	0.2	0.2	0.0	-0.0	-0.4	-0.4
Patch foraging total patch changes 18 sec	0.2	0.3	0.5	-0.3	0.5	0.5	-0.7	0.4
Patch foraging total patch changes 24 sec	0.2	0.2	0.5	0.1	0.7	0.3	-0.7	-0.1
Patch foraging total patch changes 6 sec	0.4	0.6	1.1	-0.5	0.9	0.8	-1.0	0.6
Patch foraging time to switch 0 sec	1.3	1.9	2.6	1.2	-1.6	-1.4	1.6	-0.9
Patch foraging water rate 0 sec	2.4	3.9	4.9	-1.9	2.2	2.0	-2.1	1.7
Patch foraging water rate 12 sec	3.9	5.9	7.8	-2.1	2.8	2.5	-2.7	2.0
Patch foraging water rate 18 sec	0.3	0.4	0.8	-0.6	0.9	0.7	-0.7	0.2
Patch foraging water rate 24 sec	0.3	0.5	0.8	-0.3	0.8	0.6	-0.9	0.6
Patch foraging water rate 6 sec	1.2	1.7	2.1	-1.3	1.4	1.4	-1.4	1.0
Seeking ratio, delayed vs. immediate footshock	0.6	0.7	1.0	-0.9	0.7	0.9	-0.8	1.0
Distance traveled before self-admin	0.3	0.3	0.5	-0.7	-0.5	0.0	0.4	0.7
Distance traveled after self-admin	1.3	1.4	2.0	-1.4	0.9	1.2	-1.1	1.3
Extensor digitorum longus weight	8.1	31.9	32.9	-5.6	5.6	5.7	-5.7	5.7
Bone: elastic displacement	0.4	0.4	0.5	-0.7	0.7	0.6	-0.6	0.6
Bone: elastic work	0.0	0.0	0.1	0.1	0.2	0.1	-0.2	0.1
Bone: endosteal estimation	2.1	4.7	4.9	-2.1	2.2	2.2	-2.2	2.1
Bone: endosteal perimeter	3.4	6.9	7.4	-2.5	2.7	2.7	-2.7	2.6
Epididymis fat weight	0.0	0.1	0.1	-0.2	0.3	0.2	-0.4	0.1
Delta time in closed arm before/after self-admin	0.1	0.1	0.2	0.3	-0.4	-0.3	0.5	-0.3
Delta time in open arm before/after self-admin	0.7	0.6	1.0	1.0	-0.7	-0.8	0.6	-0.8
Diff in mean of infusions in LGA sessions	1.0	1.1	1.7	-1.3	0.9	1.1	-0.8	1.0
Delay discount exponential model param	0.1	0.1	0.2	0.5	0.0	-0.1	-0.0	-0.3
Extinction: sum of active levers before priming	0.1	0.1	0.1	0.1	-0.2	-0.2	0.3	-0.3
Active lever presses in extinction session 6	0.1	0.1	0.2	-0.2	-0.5	-0.2	0.4	0.2
Bone: final force	0.5	0.7	1.1	-0.5	0.9	0.9	-1.1	0.8
Bone: final moment	0.1	0.2	0.5	-0.1	0.5	0.5	-0.7	0.4
Food consumed during 24 hour testing period	0.7	0.9	1.4	-1.2	0.7	1.0	-0.9	0.8
Glucose	0.5	0.7	1.1	-0.5	1.0	0.9	-1.0	0.6
Heart weight	0.4	0.5	0.8	-0.8	0.6	0.7	-0.6	0.9
Delay discount hyperbolic model param	0.0	0.0	0.1	0.3	0.2	0.0	-0.2	-0.2
Intermittent access intake day 1-15 change	1.1	1.1	1.5	0.9	-1.1	-1.1	1.2	-1.1
Intermittent access intake escalation	1.6	1.6	2.2	0.9	-1.3	-1.2	1.5	-1.2
Intermittent access intake escalation 2	0.1	0.1	0.2	-0.1	-0.3	-0.2	0.5	0.0
Intermitt. access day 1 inactive lever presses	1.7	1.8	2.0	1.4	-1.4	-1.4	1.2	-1.3
Intermitt. access day 15 inactive lever presses	0.2	0.2	0.6	0.1	-0.8	-0.4	0.6	-0.1
Intermitt. access escalation Index	1.2	1.0	1.2	-1.1	1.0	1.1	-1.1	0.9
Intermittent access day 1 total infusions	0.4	0.4	0.8	0.6	-0.9	-0.7	0.7	-0.2
Intermittent access day 15 total infusions	1.6	1.7	2.5	0.9	-1.6	-1.3	1.6	-1.0
Intermittent access terminal intake (last 3 days)	0.5	0.6	1.0	0.4	-1.0	-0.8	1.0	-0.3
Intermittent access total infusions	0.3	0.4	0.7	0.4	-0.8	-0.6	0.8	-0.2
Intermittent access day 1 locomotion	2.0	2.1	2.5	1.3	-1.6	-1.5	1.6	-1.1
Intermittent access day 15 total locomotion	1.9	2.0	3.2	1.3	-1.4	-1.5	1.8	-1.1
Intermittent access total locomotion	0.1	0.1	0.4	-0.0	-0.3	-0.3	0.6	0.1
Intermittent access standard deviation	1.4	1.5	2.3	0.9	-1.5	-1.3	1.5	-0.8
Left kidney weight	2.4	6.7	8.1	-2.8	2.5	2.6	-2.5	2.5
Right kidney weight	2.7	7.6	8.9	-2.9	2.6	2.8	-3.0	2.4
Cocaine induced anxiety	0.1	0.1	0.1	0.2	-0.4	-0.3	0.2	-0.2
Post-drug Anxiety	1.7	1.9	2.4	1.5	-1.3	-1.4	1.2	-1.3
Baseline Anxiety	0.3	0.3	0.5	0.7	-0.5	-0.6	0.6	-0.5
Tail length	0.1	0.4	0.8	-0.3	0.9	0.6	-0.7	0.4
Length with tail	1.0	3.6	4.7	-1.7	1.9	2.0	-2.2	1.7
Length without tail	2.2	4.8	6.4	-2.5	1.8	2.3	-2.2	2.1
Times rat made contact with spout	0.3	0.4	0.6	0.4	-0.7	-0.6	0.8	-0.6
Lifetime Intake	0.4	0.5	0.8	0.6	-0.9	-0.7	0.8	-0.3
Liver weight, left	0.7	1.2	1.8	-0.7	1.3	1.1	-1.3	0.7
Liver weight, right	1.9	3.2	4.9	-1.3	2.0	1.9	-2.2	1.4
Locomotor activity	6.0	9.6	10.4	-3.2	2.9	3.1	-3.0	3.2
Locomotor testing distance	3.1	5.2	6.4	-2.5	2.2	2.3	-2.0	2.3
Locomotor testing rearing	1.8	2.8	3.5	-1.9	1.6	1.7	-1.5	1.6
Locomotion in novel chamber	1.1	1.3	2.1	0.9	-1.0	-1.0	1.3	-1.5
Locomotion in novel chamber post-restriction	0.4	0.5	0.7	0.7	-0.9	-0.7	0.6	-0.6
Fecal boli incidents, locomotor time 1	0.0	0.0	0.1	-0.1	-0.3	-0.0	-0.0	-0.1
Change in fecal boli incidents, locomotor task	0.1	0.1	0.4	-0.1	0.6	0.3	-0.3	0.1
Time >=10cm from walls, locomotor time 1	0.2	0.2	0.5	-0.5	0.4	0.4	-0.3	0.7
Bouts of movement, locomotor time 1	0.1	0.1	0.3	-0.6	0.2	0.4	-0.4	0.2
Total resting periods, locomotor time 1	0.1	0.1	0.3	-0.5	0.2	0.3	-0.3	0.1
Rest time, locomotor task time 1	0.0	0.0	0.1	-0.1	-0.0	-0.0	0.2	-0.1
Distance moved, locomotor task time 1	0.1	0.1	0.2	0.4	-0.1	-0.3	0.2	-0.3
Vertical activity count, locomotor time 1	0.1	0.1	0.2	0.3	-0.4	-0.4	0.4	-0.3
Time >=10cm from walls, locomotor time 2	0.0	0.0	0.1	0.2	0.3	0.1	-0.2	-0.0
Bouts of movement, locomotor time 2	1.9	2.1	3.4	-1.9	1.1	1.4	-1.1	1.6
Total resting periods, locomotor time 2	2.2	2.3	3.9	-2.0	1.2	1.5	-1.1	1.8
Rest time, locomotor task time 2	0.2	0.2	0.5	0.2	-0.7	-0.4	0.5	-0.4
Distance moved, locomotor task time 2	0.1	0.1	0.2	0.4	0.2	-0.1	-0.0	-0.3
Vertical activity count, locomotor time 2	0.4	0.5	0.7	0.6	-0.7	-0.7	0.9	-0.5
Light reinforcement 1	2.5	4.6	5.6	-1.8	2.4	2.2	-2.3	1.9
Light reinforcement 2	0.2	0.3	0.5	0.7	-0.5	-0.5	0.2	-0.7
Bone: marrow area	2.2	4.7	5.0	-2.1	2.2	2.2	-2.2	2.2
Bone: maximum diameter	2.0	3.7	4.1	-1.6	2.0	2.0	-2.0	1.9
Bone: maximum force	0.5	0.9	1.1	-0.7	1.0	1.0	-1.0	1.0
Bone: maximum moment	0.2	0.3	0.5	-0.3	0.6	0.6	-0.7	0.6
Mean time between licks in bursts	0.3	0.4	0.5	0.6	-0.6	-0.6	0.7	-0.5
Mean num. licks in bursts	1.1	1.3	2.1	-1.4	0.9	1.1	-1.0	1.1
Cd content in liver	0.1	0.1	0.3	0.2	-0.3	-0.3	0.6	-0.2
Co content in liver	0.0	0.0	0.1	0.4	-0.1	-0.2	0.1	-0.1
Cu content in liver	0.3	0.4	0.6	-0.2	0.7	0.6	-0.8	0.7
Fe content in liver	0.4	0.5	0.6	0.7	-0.6	-0.7	0.6	-0.8
K content in liver	2.2	2.2	2.6	-1.4	1.5	1.5	-1.6	1.3
Mg content in liver	3.8	3.9	4.2	-1.9	2.0	2.0	-2.1	1.9
Mn content in liver	0.0	0.0	0.0	-0.0	0.0	0.1	-0.1	0.0
Na content in liver	2.7	2.8	3.8	-1.3	1.9	1.7	-2.0	1.4
Rb content in liver	1.7	2.1	2.5	-1.5	1.5	1.4	-1.2	1.6
Se content in liver	0.4	0.5	0.6	0.6	-0.6	-0.7	0.7	-0.8
Sr content in liver	0.0	0.0	0.0	0.2	-0.1	-0.1	0.0	-0.2
Zn content in liver	0.3	0.4	0.4	0.7	-0.6	-0.6	0.4	-0.6
Bone: minimum diameter	0.0	0.0	0.1	0.0	-0.2	-0.1	0.1	-0.2
Time in familiar zone, hab. session 1	0.0	0.0	0.0	0.2	0.1	-0.2	0.1	-0.2
Time in novel zone, hab. session 1	0.0	0.0	0.2	0.2	-0.4	-0.1	0.1	-0.0
Total zone transitions, hab. session 1	0.6	0.8	1.4	1.2	-0.5	-0.9	0.7	-1.0
Total locomotion distance, hab. session 1	0.1	0.1	0.2	0.4	-0.0	-0.2	0.2	-0.4
Locomotion velocity, hab. session 1	0.0	0.0	0.0	0.1	0.2	0.0	-0.0	-0.2
Time in familiar zone, hab. session 2	0.0	0.0	0.1	0.3	-0.2	-0.2	0.0	0.0
Time in novel zone, hab. session 2	0.1	0.1	0.1	0.0	-0.2	-0.2	0.3	-0.3
Total zone transitions, hab. session 2	0.2	0.3	0.6	-0.0	0.8	0.5	-0.7	0.4
Total locomotion distance, hab. session 2	0.7	0.9	1.4	-0.7	1.2	1.0	-1.0	0.8
Locomotion velocity, hab. session 2	0.3	0.4	0.8	-0.4	0.9	0.7	-0.7	0.5
Novel to familiar place preference ratio	1.1	1.1	1.8	-1.3	0.9	1.1	-0.9	1.1
Novelty place preference	1.1	1.2	1.8	-1.3	0.9	1.1	-1.0	1.1
Time in novel zone, NPP test	1.4	1.4	2.0	-1.4	1.0	1.2	-1.1	1.2
Total zone transitions, NPP test	0.2	0.3	0.8	-0.3	0.9	0.5	-0.6	0.2
Total locomotion distance, NPP test	0.6	0.9	1.3	-0.9	1.2	0.9	-1.0	0.6
Locomotion velocity, NPP test	0.2	0.3	0.7	-0.5	0.8	0.6	-0.6	0.3
Intraocular pressure	0.0	0.1	0.2	0.2	0.2	0.1	0.2	0.4
Delta distance traveled before/after self-admin	1.2	1.3	2.0	-0.8	1.4	1.2	-1.4	0.8
Delta ambulatory time before/after self-admin	0.5	0.6	1.1	-0.4	1.0	0.7	-1.0	0.3
Parametrial fat weight	0.0	0.1	0.1	0.3	0.3	0.2	-0.3	0.3
Pavlov. Cond. lever latency	0.1	0.1	0.2	0.3	-0.5	-0.3	0.5	0.1
Pavlov. Cond. magazine entry latency	0.7	0.9	1.3	1.1	-0.8	-0.9	0.7	-1.0
Pavlov. Cond. change in total contacts	0.0	0.0	0.1	-0.1	-0.0	0.0	-0.1	-0.4
Pavlov. Cond. index score	0.5	0.7	1.2	0.9	-0.7	-0.8	0.5	-1.1
Pavlov. Cond. latency score	0.2	0.3	0.7	0.6	-0.3	-0.4	0.2	-0.8
Pavlov. Cond. lever contacts	0.1	0.1	0.2	0.2	0.1	-0.1	-0.2	-0.5
Pavlov. Cond. magazine entry number	1.0	1.3	1.6	-1.3	1.1	1.1	-0.9	1.3
Pavlov. Cond. intertrial magazine entries	0.1	0.1	0.2	-0.3	0.4	0.3	-0.5	0.3
Pavlov. Cond. lever-magazine prob. diff.	0.3	0.4	0.8	0.8	-0.5	-0.6	0.3	-0.9
Pavlov. Cond. response bias	0.4	0.5	0.9	0.8	-0.6	-0.7	0.5	-1.0
Pavlov. Cond. lever latency	0.6	0.9	1.5	-1.1	0.7	0.9	-0.6	1.2
Pavlov. Cond. magazine entry latency	3.3	3.8	5.0	2.0	-1.8	-1.9	1.7	-2.2
Pavlov. Cond. change in total contacts	0.4	0.5	0.9	0.7	-0.7	-0.7	0.5	-0.9
Pavlov. Cond. index score	1.0	1.2	2.0	1.2	-1.0	-1.1	0.8	-1.4
Pavlov. Cond. latency score	0.6	0.8	1.3	0.9	-0.7	-0.8	0.6	-1.2
Pavlov. Cond. lever contacts	0.2	0.3	0.6	0.6	-0.4	-0.5	0.3	-0.8
Pavlov. Cond. magazine entry number	3.0	3.6	4.5	-2.0	1.8	1.9	-1.7	2.1
Pavlov. Cond. intertrial magazine entries	0.6	0.8	0.9	-0.7	0.9	0.9	-0.9	1.0
Pavlov. Cond. lever-magazine prob. diff.	1.1	1.4	2.1	1.3	-1.0	-1.2	0.9	-1.4
Pavlov. Cond. response bias	1.0	1.4	2.0	1.3	-1.0	-1.2	1.0	-1.4
Time in closed arm before self-admin	0.2	0.2	0.6	-0.2	-0.4	-0.2	0.8	-0.0
Time in closed arm after self-admin	0.2	0.2	0.6	-0.1	-0.5	-0.3	0.8	-0.2
Time in open arm before self-admin	0.8	0.8	1.7	-0.7	0.7	0.9	-1.3	0.8
Time in open arm after self-admin	0.1	0.1	0.4	0.2	0.1	0.0	-0.7	-0.0
Bone: periosteal estimation	1.2	2.6	2.9	-1.4	1.6	1.7	-1.7	1.5
Bone: periosteal perimeter	1.9	3.2	3.6	-1.6	1.8	1.9	-1.9	1.7
Bone: post-yield work	0.1	0.1	0.2	-0.4	0.3	0.4	-0.2	0.4
Progressive ratio test 1 active lever presses	0.1	0.1	0.5	-0.3	0.2	0.3	-0.2	0.7
Progressive ratio test 1 breakpoint	0.0	0.0	0.1	0.1	-0.1	-0.1	0.3	0.3
Progressive ratio test 1 inactive lever presses	0.9	1.0	1.6	1.3	-1.0	-1.0	0.8	-0.8
Progressive ratio test 2 active lever presses	0.2	0.2	0.7	-0.6	0.2	0.3	-0.1	0.8
Progressive ratio test 2 breakpoint	0.4	0.4	1.0	-0.7	0.4	0.6	-0.4	1.0
Progressive ratio test 2 inactive lever presses	0.6	0.7	1.1	0.6	-1.1	-0.8	0.9	-0.6
Incentive Sensitization - Responses	0.3	0.4	0.6	-0.8	0.4	0.5	-0.4	0.8
Incentive Sensitization - Breakpoint	0.2	0.2	0.4	-0.6	0.2	0.3	-0.2	0.5
Sum of active levers in priming session hrs 5-6	0.0	0.0	0.0	-0.1	0.0	0.2	0.0	0.1
Progressive ratio	0.9	1.0	1.8	0.5	-1.4	-1.0	1.2	-0.8
Food seeking constrained by brief footshock	0.6	0.7	0.9	-0.7	0.9	0.8	-0.9	0.8
Seeking ratio, punishment vs. effort	3.8	4.7	6.5	-1.6	2.6	2.2	-2.5	1.8
Retroperitoneal fat weight	0.1	0.2	0.3	-0.1	0.5	0.4	-0.6	0.2
Reaction time number correct	1.7	2.4	3.0	-1.6	1.7	1.5	-1.2	1.7
Reaction time mean minus median	0.1	0.1	0.2	0.2	-0.2	-0.3	-0.1	-0.5
Reaction time mean minus median AUC	0.5	0.6	1.1	0.9	-0.7	-0.8	0.4	-1.0
Reaction time num false alarms	0.7	1.0	1.5	1.2	-0.9	-0.9	0.7	-1.1
Reaction time num false alarms AUC	0.2	0.3	0.6	0.8	-0.4	-0.5	0.3	-0.7
Reaction time trials correct on left	1.7	2.4	3.0	-1.6	1.7	1.5	-1.2	1.7
Reaction time trials on left	1.8	2.6	3.2	-1.6	1.7	1.6	-1.3	1.8
Reaction time mean	2.3	3.3	4.3	2.0	-1.6	-1.8	1.5	-2.1
Reaction time mean AUC	1.7	2.3	3.1	1.6	-1.3	-1.5	1.2	-1.7
Median of all reaction times	3.7	5.0	6.2	2.4	-2.0	-2.3	2.0	-2.5
Reaction time omissions	0.4	0.5	0.7	-0.7	0.7	0.7	-0.8	0.7
Reaction time false alarm rate	1.6	2.2	2.9	1.7	-1.4	-1.4	1.1	-1.7
Reaction time premature initiation rate	1.8	2.4	3.2	-1.3	1.6	1.6	-1.5	1.8
Reaction time premature initiations	3.1	4.4	5.5	-1.9	2.2	2.1	-1.9	2.4
Std. dev. reaction times	0.7	1.0	1.5	1.1	-0.9	-1.0	0.6	-1.2
Reaction time trials completed	1.8	2.6	3.2	-1.6	1.7	1.6	-1.3	1.8
Reaction time trials AUC	1.5	2.1	2.7	-1.5	1.6	1.4	-1.1	1.6
Run reversals in cocaine runway, females	0.0	0.0	0.0	-0.1	0.1	0.1	0.1	0.2
Run reversals in cocaine runway, males	0.0	0.0	0.0	-0.1	0.2	0.2	-0.1	0.2
Latency to leave start box in cocaine runway	2.4	2.6	3.7	-1.9	1.3	1.5	-1.4	1.8
Latency to leave start box in cocaine runway, F	0.4	0.5	1.0	-1.0	0.5	0.6	-0.6	0.6
Latency to leave start box in cocaine runway, M	3.8	3.6	5.2	-2.0	1.6	1.9	-1.6	2.3
Std. dev. time between licks in bursts	0.4	0.4	0.7	-0.5	0.8	0.7	-0.8	0.4
Total sessions with >9 infusions	0.0	0.0	0.1	0.3	-0.1	-0.1	-0.0	0.1
Short access day 1 total inactive lever presses	0.1	0.1	0.4	0.6	-0.2	-0.3	0.2	-0.1
Short access day 10 total inactive lever presses	0.9	1.0	1.5	0.8	-1.1	-1.0	1.2	-0.8
Short access day 1 total infusions	0.3	0.3	0.5	0.6	-0.7	-0.6	0.6	-0.1
Short access day 10 total infusions	0.2	0.3	0.4	0.6	-0.7	-0.6	0.4	-0.3
Short access total infusions	0.7	0.7	1.1	1.0	-0.9	-0.9	0.8	-0.5
Short access day 1 locomotion	0.0	0.1	0.2	0.4	-0.2	-0.2	0.1	0.1
Short access day 10 total locomotion	0.0	0.0	0.0	-0.1	0.1	0.1	-0.2	0.1
Short access total locomotion	0.7	0.8	1.0	1.0	-0.9	-1.0	0.7	-0.8
One hour access (0.3 mA shock)	0.1	0.1	0.5	-0.4	0.0	0.2	0.0	0.7
Compulsive drug intake	0.4	0.4	0.7	-0.3	0.8	0.7	-0.8	0.5
One hour access (shock baseline)	0.5	0.5	1.0	0.4	-1.0	-0.7	1.0	-0.2
Social response proportion	0.1	0.1	0.3	0.1	-0.5	-0.4	0.3	-0.5
Social responses	0.1	0.1	0.4	-0.3	0.3	0.3	-0.6	0.1
Social time	0.0	0.1	0.2	-0.5	-0.2	0.1	-0.1	0.2
Soleus weight	16.9	49.4	50.4	-7.0	7.0	7.0	-7.1	7.0
Bone: stiffness	1.2	1.9	2.0	-1.4	1.3	1.4	-1.4	1.4
Tibialis anterior weight	12.7	43.6	44.8	-6.6	6.5	6.6	-6.7	6.6
Time to tail flick, vehicle, before self-admin	0.1	0.1	0.3	0.4	0.0	-0.2	0.2	-0.5
Time to tail flick, vehicle, after self-admin	0.2	0.2	0.7	-0.1	-0.6	-0.4	0.8	-0.2
Time to tail flick, test, before self-admin	0.8	0.8	1.0	1.0	-0.9	-0.9	0.8	-1.0
Time to tail flick, test, after self-admin	1.6	1.7	3.3	0.8	-1.8	-1.4	1.4	-0.5
Delta time to tail flick, vehicle, before/after SA	0.2	0.2	0.5	0.0	-0.7	-0.5	0.6	-0.2
Delta time to tail flick, test, before/after SA	0.1	0.1	0.2	-0.4	-0.3	-0.1	0.2	0.5
Tibia length	0.1	0.2	0.4	0.2	-0.5	-0.4	0.6	-0.6
Ambulatory time before self-admin	0.2	0.2	0.4	-0.1	-0.6	-0.3	0.5	0.1
Ambulatory time after self-admin	0.5	0.6	0.8	-0.8	0.7	0.7	-0.9	0.8
Bone: tissue strength	1.6	1.6	1.8	1.2	-1.3	-1.3	1.2	-1.2
Total heroin consumption	2.0	2.3	3.2	-1.6	1.3	1.5	-1.4	1.8
Bone: trabecular number	1.6	2.5	2.9	1.6	-1.3	-1.6	1.5	-1.7
Bone: trabecular spacing	0.0	0.0	0.0	-0.2	0.0	0.1	-0.1	0.2
Bone: trabecular thickness	0.2	0.3	0.4	0.6	-0.4	-0.5	0.6	-0.5
Bone: trabecular tissue density	5.5	7.8	8.7	-2.6	3.0	2.8	-2.8	2.8
Water consumed over 24 hours	0.5	0.6	0.8	0.6	-0.8	-0.7	0.7	-0.9
Number of responses in last shaping day	0.1	0.1	0.1	0.0	-0.2	-0.2	0.4	-0.2