Hub : Genes

Slc4a8

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Liver gene expression Slc4a8 0.04 0.03 1.6e-04 0.03 0.03 0.02 0.02 2.2e-04 6.2e-04 4.7e-03 9.6e-04
2 NAcc isoform ratio NM_199497.3 0.02 0.01 7.0e-03 0 0.01 0 0.01 4.5e-02 1.0e-02 6.3e-02 3.3e-02
3 PL mRNA stability Slc4a8 0.06 0.03 1.9e-06 0.04 0.04 0.04 0.04 2.5e-05 1.1e-05 2.9e-05 6.2e-05
4 PL gene expression Slc4a8 0.04 0.03 3.3e-03 0.03 0.02 0.03 0.02 6.5e-04 1.1e-03 8.3e-04 1.2e-03
5 Adipose gene expression Slc4a8 0.19 0.08 0.0e+00 0.21 0.21 0.21 0.22 1.5e-22 2.6e-23 2.3e-23 6.7e-24
6 NAcc gene expression Slc4a8 0.03 0.03 1.1e-04 0.02 0.02 0.02 0.02 1.3e-03 1.8e-04 3.0e-04 4.1e-04
7 pVTA intron excision ratio chr7_133796166_133799035 0.04 0.03 8.3e-03 0.02 0.01 0.01 0.01 1.3e-02 4.0e-02 8.7e-02 6.3e-02
8 pVTA gene expression Slc4a8 0.11 0.07 1.6e-07 0.11 0.09 0.1 0.11 2.3e-09 1.8e-07 3.8e-08 3.9e-09
9 Brain mRNA stability Slc4a8 0.25 0.1 0.0e+00 0.25 0.27 0.27 0.26 2.5e-23 1.5e-25 4.3e-25 1.2e-24
10 pVTA mRNA stability Slc4a8 0.04 0.03 9.3e-03 0.03 0.03 0.03 0.03 2.5e-03 2.1e-03 2.7e-03 3.5e-03
11 BLA gene expression Slc4a8 0.1 0.07 3.7e-03 0.01 0.03 0.03 0.01 1.3e-01 9.0e-03 1.3e-02 6.1e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11
Bone: apparent density0.71.29.7-3.10.9-0.6-0.20.5-0.30.4-0.6-0.10.50.9
Area under the delay curve0.20.30.5-0.70.5-0.4-0.60.6-0.5-0.6-0.6-0.3-0.2-0.1
BMI with tail1.65.728.7-5.42.6-2.3-2.51.4-1.9-2.4-1.3-1.4-0.7-0.1
BMI without tail0.41.27.7-2.81.3-1.0-0.70.6-0.7-0.9-0.4-0.6-0.20.1
Body weight1.04.332.9-5.72.0-1.5-1.50.8-1.2-1.4-0.6-0.60.31.0
Weight adjusted by age2.33.54.7-0.91.9-1.9-2.22.0-1.9-1.9-2.0-1.9-1.9-1.8
Bone surface1.01.816.2-4.01.1-0.7-0.50.3-0.4-0.2-0.4-0.00.61.1
Bone volume0.91.613.4-3.71.3-0.9-0.50.6-0.6-0.1-0.7-0.30.30.7
Breakpoint value in progressive ratio session0.10.21.0-1.00.00.10.2-0.10.2-0.1-0.10.30.40.6
Number of licking bursts0.30.53.01.7-0.0-0.1-0.10.4-0.4-0.8-0.3-0.4-0.6-0.8
Context. condit. distance diff. score0.30.31.2-1.1-0.20.30.4-0.40.40.20.40.50.70.8
Locomotion velocity, session 10.80.83.31.8-1.21.00.2-0.80.90.70.80.80.40.2
Locomotion distance, session 10.30.43.61.9-0.60.4-0.0-0.30.30.30.30.1-0.3-0.5
Locomotion velocity, session 20.40.40.60.7-0.80.80.4-0.60.70.70.50.70.50.5
Locomotion distance, session 20.60.96.02.5-1.00.70.4-0.70.60.70.60.40.0-0.3
Locomotion velocity, session 32.83.16.32.5-2.01.92.0-1.81.71.61.81.51.20.9
Locomotion distance, session 34.14.47.61.8-2.12.22.7-1.92.22.81.92.01.81.6
Stereotopy head waving bouts, day 31.92.33.90.41.3-1.5-1.61.3-1.6-2.0-1.2-1.6-1.7-1.8
Stereotopy head waving duration, day 30.20.30.80.80.1-0.3-0.40.1-0.5-0.90.1-0.4-0.5-0.7
Locomotion velocity, session 72.73.04.71.8-1.81.72.2-1.81.82.11.81.51.31.1
Locomotion distance, session 73.74.65.82.2-2.42.32.2-2.22.32.22.22.11.81.6
Stereotopy head waving bouts, day 74.44.95.9-1.12.4-2.4-2.02.4-2.4-1.9-2.3-2.4-2.4-2.2
Stereotopy head waving duration, day 72.73.34.0-1.12.0-2.0-1.71.9-2.0-1.7-1.8-2.0-1.9-1.8
Locomotion velocity, session 80.00.00.20.4-0.20.10.3-0.10.20.20.20.1-0.1-0.1
Locomotion distance, session 80.71.01.50.8-1.21.10.8-1.11.10.91.01.10.90.8
Degree of sensitization distance0.40.51.4-0.20.5-0.6-1.20.4-0.6-1.2-0.3-0.5-0.6-0.6
Degree of sensitization stereotypy3.53.84.8-1.32.2-2.1-1.82.2-2.0-1.5-2.2-2.1-2.0-1.8
Conditioned locomotion0.30.40.80.8-0.70.60.9-0.60.60.50.60.50.50.4
Cocaine response after cond. corrected0.20.20.50.30.4-0.5-0.60.3-0.6-0.5-0.4-0.5-0.6-0.7
Cocaine response after cond. not corrected0.00.10.30.6-0.1-0.0-0.0-0.1-0.10.2-0.0-0.1-0.2-0.3
Cocaine response before conditioning1.61.92.51.1-1.51.51.3-1.41.51.61.31.41.21.1
Saline control response0.50.71.60.2-0.70.71.1-0.80.81.30.90.70.80.8
Bone: connectivity density0.40.75.0-2.20.20.10.1-0.10.30.40.10.50.81.1
Bone: cortical apparent density1.41.93.80.71.1-1.4-1.31.2-1.5-1.3-1.1-1.6-1.7-1.9
Bone: cortical area0.81.29.2-3.01.1-0.8-0.60.5-0.6-0.2-0.6-0.30.20.5
Bone: cortical porosity0.91.01.5-0.2-0.91.01.0-1.01.01.20.91.11.21.2
Bone: cortical porosity1.21.42.00.0-1.11.11.2-1.21.21.41.11.21.31.3
Bone: cortical thickness0.30.53.5-1.90.8-0.6-0.60.4-0.5-0.4-0.4-0.3-0.00.2
Bone: cortical thickness0.70.92.80.4-0.80.81.0-0.80.91.70.90.80.80.8
Bone: cortical tissue density1.31.73.60.81.0-1.3-1.21.2-1.4-1.2-1.0-1.5-1.7-1.9
Condit. Reinf. active minus inactive responses0.00.00.2-0.40.2-0.2-0.50.1-0.10.0-0.1-0.1-0.2-0.1
Condit. Reinf. active-inactive response ratio0.20.20.5-0.7-0.20.30.3-0.40.40.50.40.50.50.6
Condit. Reinf. active responses0.10.10.40.30.0-0.1-0.60.2-0.1-0.1-0.2-0.2-0.4-0.4
Condit. Reinf. inactive responses0.40.52.91.7-0.1-0.1-0.60.2-0.2-0.3-0.3-0.4-0.7-0.9
Incentive salience index mean0.40.51.2-0.80.7-0.7-1.10.7-0.6-0.6-0.8-0.6-0.6-0.4
Condit. Reinf. lever presses1.42.03.6-1.21.4-1.4-1.91.5-1.3-1.5-1.6-1.2-1.2-1.0
Condit. Reinf. active minus inactive responses0.50.71.6-1.30.9-0.9-1.00.7-0.8-0.9-0.6-0.7-0.5-0.4
Condit. Reinf. active-inactive response ratio0.20.20.9-1.00.5-0.4-0.40.1-0.4-0.5-0.1-0.3-0.1-0.1
Condit. Reinf. active responses0.20.30.5-0.60.7-0.7-0.60.6-0.6-0.3-0.5-0.6-0.6-0.5
Condit. Reinf. inactive responses0.10.10.20.40.1-0.2-0.30.3-0.10.3-0.3-0.3-0.4-0.5
Condit. Reinf. lever presses0.81.11.50.3-1.01.11.0-1.21.10.71.21.11.21.1
Condit. Reinf. lever reinforcers received0.00.00.1-0.30.2-0.2-0.20.1-0.10.00.0-0.1-0.1-0.1
Conditioned reinforcement - actives0.40.71.81.4-0.90.81.1-0.80.80.90.70.60.50.4
Conditioned reinforcement - inactives1.42.16.82.6-1.51.41.6-1.21.31.71.01.10.70.5
Conditioned locomotion0.60.81.20.8-1.01.01.1-1.10.90.41.00.90.90.8
Patch foraging indifference point 0 sec1.22.35.72.4-1.71.51.9-1.11.61.71.41.20.80.6
Patch foraging indifference point AUC0.40.51.11.10.3-0.4-0.40.8-0.6-0.8-0.8-0.7-0.9-1.0
Delay disc. indifference point, 0s delay0.20.21.2-1.10.5-0.3-0.30.5-0.4-0.6-0.5-0.20.00.2
Delay disc. indifference point, 16s delay0.10.10.5-0.70.2-0.1-0.20.1-0.0-0.2-0.10.10.20.3
Delay disc. indifference point, 2s delay4.75.26.4-1.42.5-2.5-2.32.4-2.5-2.1-2.2-2.4-2.3-2.2
Delay disc. indifference point, 24s delay0.20.21.1-0.60.3-0.3-0.80.2-0.4-1.1-0.1-0.2-0.1-0.1
Delay disc. indifference point, 4s delay0.30.30.8-0.90.6-0.6-0.50.7-0.5-0.5-0.7-0.4-0.2-0.1
Delay disc. indifference point, 8s delay0.20.20.7-0.7-0.20.40.3-0.20.40.30.30.50.80.8
Indifference point function ln k0.50.86.8-2.60.8-0.6-0.50.2-0.4-0.3-0.2-0.10.30.5
Indifference point function log k0.50.86.8-2.60.8-0.6-0.50.2-0.4-0.3-0.2-0.10.30.5
Patch foraging total patch changes 0 sec1.63.05.72.4-1.91.82.2-1.41.81.91.71.41.10.9
Patch foraging total patch changes 12 sec0.71.05.52.4-1.20.90.9-0.50.90.50.60.60.2-0.1
Patch foraging total patch changes 18 sec1.01.57.52.7-1.31.21.2-0.61.11.20.80.70.30.0
Patch foraging total patch changes 24 sec0.50.93.92.0-1.10.91.1-0.41.01.00.50.60.30.2
Patch foraging total patch changes 6 sec0.91.47.52.7-1.31.11.1-0.71.00.90.90.70.2-0.1
Patch foraging time to switch 0 sec0.20.42.81.7-0.1-0.00.20.2-0.00.2-0.1-0.4-0.6-0.8
Patch foraging water rate 0 sec0.40.76.2-2.50.4-0.2-0.5-0.2-0.1-0.40.10.20.60.9
Patch foraging water rate 12 sec0.20.53.4-1.80.10.10.1-0.10.20.20.10.40.71.0
Patch foraging water rate 18 sec0.00.00.3-0.50.0-0.0-0.0-0.1-0.10.00.10.10.20.2
Patch foraging water rate 24 sec0.50.84.9-2.20.9-0.7-0.70.5-0.6-0.8-0.5-0.40.00.2
Patch foraging water rate 6 sec0.71.08.1-2.80.7-0.4-0.20.3-0.3-0.5-0.50.10.50.9
Seeking ratio, delayed vs. immediate footshock0.10.10.5-0.70.3-0.2-0.70.3-0.2-0.5-0.3-0.1-0.00.1
Distance traveled before self-admin0.30.41.41.2-0.80.60.8-0.50.60.60.40.40.20.0
Distance traveled after self-admin3.13.84.80.6-2.22.11.7-2.22.11.92.22.12.01.8
Extensor digitorum longus weight6.123.831.3-4.85.6-5.4-4.75.1-5.1-4.9-4.9-4.9-4.3-3.8
Bone: elastic displacement3.74.28.72.9-2.52.21.7-2.32.01.72.21.91.51.1
Bone: elastic work1.82.33.50.7-1.71.71.1-1.91.51.11.81.71.61.5
Bone: endosteal estimation0.61.412.2-3.50.8-0.4-0.00.1-0.20.2-0.10.20.91.3
Bone: endosteal perimeter0.71.410.8-3.31.3-0.9-0.40.8-0.7-0.3-0.8-0.40.20.6
Epididymis fat weight2.06.811.3-0.9-2.42.61.9-2.82.72.12.73.03.23.4
Delta time in closed arm before/after self-admin0.20.20.3-0.3-0.30.30.6-0.30.40.20.30.40.50.5
Delta time in open arm before/after self-admin2.82.73.50.9-1.91.81.5-1.61.81.91.61.81.61.5
Diff in mean of infusions in LGA sessions1.01.22.3-1.51.2-1.1-1.01.1-0.9-1.2-1.3-0.9-0.8-0.6
Delay discount exponential model param0.30.40.60.7-0.60.60.7-0.80.60.70.70.50.30.2
Extinction: sum of active levers before priming1.71.94.8-2.21.4-1.3-1.51.3-1.2-1.8-1.4-1.0-0.8-0.6
Active lever presses in extinction session 60.60.61.0-0.3-0.70.70.6-1.00.70.90.80.80.90.9
Bone: final force1.32.017.7-4.20.9-0.4-0.6-0.0-0.2-0.1-0.10.31.01.5
Bone: final moment1.42.218.9-4.30.8-0.3-0.4-0.2-0.10.00.10.51.21.7
Food consumed during 24 hour testing period0.81.13.2-1.8-0.50.7-0.2-1.00.80.00.81.11.31.6
Glucose0.10.10.20.4-0.40.40.0-0.30.40.30.40.30.20.2
Heart weight0.71.01.9-0.7-0.70.81.1-0.90.91.40.91.01.21.3
Delay discount hyperbolic model param0.40.50.80.7-0.80.70.7-0.90.70.70.80.60.50.4
Intermittent access intake day 1-15 change0.81.62.5-0.1-1.11.21.0-1.41.31.41.41.41.51.6
Intermittent access intake escalation0.30.71.4-0.5-0.60.70.6-0.80.80.90.80.91.11.2
Intermittent access intake escalation 20.60.71.2-0.3-0.70.80.7-0.80.81.00.80.91.01.1
Intermitt. access day 1 inactive lever presses0.00.10.30.50.1-0.2-0.3-0.1-0.2-0.60.3-0.3-0.4-0.4
Intermitt. access day 15 inactive lever presses0.10.20.40.0-0.40.30.7-0.40.30.40.60.30.30.2
Intermitt. access escalation Index2.02.93.5-0.31.6-1.6-1.91.8-1.7-1.8-1.8-1.8-1.9-1.8
Intermittent access day 1 total infusions0.61.02.41.6-1.00.91.4-1.00.90.91.00.70.50.3
Intermittent access day 15 total infusions0.71.01.70.9-1.01.01.3-1.11.01.01.10.90.80.7
Intermittent access terminal intake (last 3 days)0.70.91.81.0-0.90.91.3-1.10.91.11.10.80.70.5
Intermittent access total infusions0.91.12.01.4-1.01.01.4-1.10.91.11.10.80.70.5
Intermittent access day 1 locomotion1.31.62.51.6-1.41.31.5-1.41.21.01.41.11.00.8
Intermittent access day 15 total locomotion2.74.85.61.3-2.22.32.4-2.22.32.32.22.32.32.2
Intermittent access total locomotion2.93.55.32.3-2.01.92.1-1.91.81.81.91.71.51.3
Intermittent access standard deviation1.73.44.40.2-1.81.92.0-2.01.92.12.11.91.91.9
Left kidney weight0.21.08.7-2.90.9-0.6-0.50.4-0.4-0.1-0.5-0.10.30.7
Right kidney weight0.83.824.0-4.92.1-1.6-1.51.4-1.3-1.1-1.5-0.9-0.20.4
Cocaine induced anxiety0.20.32.4-1.60.2-0.00.1-0.20.10.30.10.30.60.8
Post-drug Anxiety0.60.62.4-1.6-0.10.30.5-0.60.50.50.50.71.01.3
Baseline Anxiety0.20.20.8-0.20.4-0.4-0.40.4-0.4-0.9-0.4-0.3-0.3-0.2
Tail length0.20.82.50.1-0.60.71.6-0.50.81.20.70.80.90.9
Length with tail0.20.75.6-2.40.4-0.20.30.1-0.00.10.10.20.81.0
Length without tail0.62.116.6-4.11.2-0.8-0.90.6-0.7-0.8-0.5-0.20.51.0
Times rat made contact with spout0.20.30.7-0.4-0.50.60.0-0.40.60.10.40.70.70.8
Lifetime Intake1.82.23.71.8-1.61.51.9-1.61.41.51.61.31.10.8
Liver weight, left1.11.815.5-3.91.0-0.5-0.1-0.1-0.3-0.10.00.10.91.3
Liver weight, right0.50.94.6-2.20.00.30.5-0.60.40.60.70.71.11.3
Locomotor activity0.20.31.21.1-0.60.50.1-0.50.50.70.60.40.20.1
Locomotor testing distance0.51.03.41.9-1.11.00.6-0.90.91.11.10.70.30.2
Locomotor testing rearing0.81.63.61.1-1.31.31.4-1.11.41.91.21.10.90.9
Locomotion in novel chamber0.81.03.6-1.91.3-1.1-0.60.9-1.0-1.0-0.8-0.8-0.4-0.1
Locomotion in novel chamber post-restriction0.30.61.0-0.1-0.70.70.5-0.90.70.50.80.91.01.0
Fecal boli incidents, locomotor time 11.92.74.10.8-1.81.81.2-2.01.71.32.01.81.71.6
Change in fecal boli incidents, locomotor task1.00.91.40.11.0-1.0-0.81.0-1.1-0.6-1.1-1.1-1.1-1.2
Time >=10cm from walls, locomotor time 10.50.61.01.0-0.90.80.6-0.90.70.61.00.70.60.4
Bouts of movement, locomotor time 10.20.20.60.20.3-0.3-0.70.4-0.5-0.8-0.5-0.4-0.4-0.5
Total resting periods, locomotor time 10.10.10.90.9-0.20.1-0.30.0-0.1-0.2-0.1-0.1-0.3-0.4
Rest time, locomotor task time 10.30.31.41.2-0.60.50.4-0.40.30.80.40.30.2-0.0
Distance moved, locomotor task time 10.10.20.30.10.4-0.4-0.30.3-0.5-0.5-0.4-0.5-0.5-0.5
Vertical activity count, locomotor time 10.30.81.8-1.31.1-1.0-0.70.8-0.8-0.8-0.9-0.8-0.7-0.5
Time >=10cm from walls, locomotor time 20.40.50.90.9-0.70.70.8-0.80.60.81.00.60.50.3
Bouts of movement, locomotor time 20.71.13.8-1.91.2-1.1-0.91.0-1.0-1.1-0.9-0.8-0.5-0.3
Total resting periods, locomotor time 21.01.74.3-2.11.5-1.4-1.21.4-1.3-1.2-1.3-1.1-0.8-0.6
Rest time, locomotor task time 20.10.10.40.60.1-0.10.00.2-0.20.3-0.3-0.3-0.3-0.4
Distance moved, locomotor task time 20.10.10.30.20.2-0.2-0.40.1-0.2-0.6-0.1-0.3-0.3-0.4
Vertical activity count, locomotor time 20.10.20.4-0.60.3-0.3-0.70.4-0.3-0.7-0.3-0.2-0.2-0.1
Light reinforcement 10.10.32.51.6-0.30.10.10.1-0.1-0.5-0.2-0.2-0.4-0.6
Light reinforcement 20.20.31.10.00.4-0.3-0.30.9-0.4-0.7-1.1-0.4-0.4-0.3
Bone: marrow area0.61.411.5-3.40.7-0.30.00.1-0.10.3-0.00.30.91.3
Bone: maximum diameter0.20.32.5-1.60.7-0.5-0.10.4-0.40.0-0.3-0.30.10.3
Bone: maximum force1.73.021.8-4.71.7-1.3-1.40.8-1.1-0.8-0.9-0.50.30.8
Bone: maximum moment1.62.822.9-4.81.5-1.1-1.10.5-0.9-0.7-0.6-0.30.51.1
Mean time between licks in bursts0.20.61.51.2-0.90.80.4-1.00.5-0.11.00.70.50.3
Mean num. licks in bursts0.91.42.7-1.6-0.70.90.6-1.11.21.41.11.21.41.6
Cd content in liver0.30.30.60.7-0.60.50.8-0.70.5-0.10.80.50.40.3
Co content in liver0.10.20.5-0.20.4-0.4-0.30.6-0.2-0.2-0.7-0.4-0.4-0.3
Cu content in liver0.20.30.8-0.6-0.10.30.80.10.50.9-0.00.40.50.6
Fe content in liver0.60.83.31.8-0.80.71.4-0.50.60.90.70.40.20.0
K content in liver0.00.00.30.00.00.0-0.00.20.10.6-0.1-0.0-0.1-0.0
Mg content in liver0.20.20.40.3-0.50.50.1-0.50.50.60.60.50.40.4
Mn content in liver0.40.51.3-0.20.6-0.6-1.10.7-0.6-0.4-0.9-0.6-0.7-0.6
Na content in liver0.10.10.4-0.50.00.10.40.40.30.6-0.30.20.20.4
Rb content in liver0.80.91.20.9-1.00.91.1-1.01.01.11.10.80.70.6
Se content in liver0.91.13.82.0-1.21.11.0-0.91.00.91.00.80.50.3
Sr content in liver0.20.20.5-0.7-0.10.20.5-0.00.30.5-0.10.30.40.6
Zn content in liver1.11.21.61.2-1.31.21.2-1.21.10.91.21.11.00.8
Bone: minimum diameter0.81.510.4-3.21.4-1.0-0.60.8-0.9-0.7-0.8-0.50.10.4
Time in familiar zone, hab. session 10.10.10.8-0.40.1-0.2-0.9-0.1-0.2-0.6-0.0-0.0-0.1-0.1
Time in novel zone, hab. session 10.20.20.40.40.5-0.40.20.6-0.5-0.2-0.5-0.6-0.5-0.6
Total zone transitions, hab. session 12.02.84.00.11.5-1.6-1.91.7-1.7-1.5-1.7-1.8-2.0-2.0
Total locomotion distance, hab. session 10.10.20.50.70.0-0.1-0.60.0-0.3-0.2-0.0-0.3-0.5-0.6
Locomotion velocity, hab. session 10.10.10.30.60.0-0.1-0.60.0-0.3-0.30.0-0.2-0.4-0.5
Time in familiar zone, hab. session 20.40.42.8-1.70.1-0.0-0.5-0.30.1-0.60.10.30.50.7
Time in novel zone, hab. session 20.40.42.91.7-0.0-0.10.50.3-0.20.4-0.1-0.5-0.6-0.9
Total zone transitions, hab. session 20.10.10.60.8-0.10.0-0.10.1-0.10.2-0.2-0.2-0.3-0.3
Total locomotion distance, hab. session 20.20.31.41.2-0.50.40.3-0.40.30.50.40.20.1-0.0
Locomotion velocity, hab. session 20.20.31.01.0-0.60.60.4-0.50.40.60.50.40.30.2
Novel to familiar place preference ratio2.22.43.2-1.31.8-1.7-1.31.7-1.6-1.5-1.6-1.6-1.4-1.3
Novelty place preference1.82.02.6-1.11.6-1.5-1.21.5-1.5-1.4-1.5-1.5-1.3-1.2
Time in novel zone, NPP test1.92.12.6-0.91.6-1.5-1.21.5-1.5-1.5-1.5-1.5-1.4-1.3
Total zone transitions, NPP test0.40.65.02.2-0.40.2-0.10.20.00.3-0.2-0.2-0.5-0.8
Total locomotion distance, NPP test0.91.27.62.8-1.31.00.6-0.70.70.70.70.60.2-0.1
Locomotion velocity, NPP test0.71.05.62.4-1.31.10.6-0.70.80.80.70.70.40.1
Intraocular pressure2.23.16.02.4-2.11.81.7-1.81.81.51.91.61.20.9
Delta distance traveled before/after self-admin4.75.06.9-0.5-2.22.31.8-2.42.32.32.42.52.62.6
Delta ambulatory time before/after self-admin4.04.96.3-0.2-2.12.21.8-2.42.32.52.42.42.52.5
Parametrial fat weight1.12.54.00.9-1.91.70.4-2.01.70.72.01.81.71.5
Pavlov. Cond. lever latency1.21.52.41.1-1.31.21.5-1.41.11.31.41.11.10.8
Pavlov. Cond. magazine entry latency1.51.92.6-1.61.6-1.5-1.31.5-1.4-1.4-1.4-1.3-1.1-1.0
Pavlov. Cond. change in total contacts3.03.24.3-1.92.0-1.9-2.11.9-1.8-1.8-1.8-1.7-1.5-1.3
Pavlov. Cond. index score2.93.74.9-1.92.2-2.0-2.02.2-1.8-1.8-2.2-1.8-1.7-1.4
Pavlov. Cond. latency score2.63.34.3-1.82.0-1.9-1.92.1-1.7-1.7-2.0-1.7-1.6-1.3
Pavlov. Cond. lever contacts1.21.42.0-1.11.3-1.2-1.41.4-1.0-1.1-1.4-1.1-1.0-0.8
Pavlov. Cond. magazine entry number1.01.21.81.3-1.31.21.1-1.21.11.11.11.00.90.7
Pavlov. Cond. intertrial magazine entries1.61.95.42.3-1.81.51.0-1.41.41.11.31.20.80.6
Pavlov. Cond. lever-magazine prob. diff.3.03.74.7-2.02.1-2.0-2.12.2-1.8-1.8-2.2-1.8-1.6-1.3
Pavlov. Cond. response bias0.70.81.0-1.01.0-0.9-1.01.0-0.9-0.9-1.0-0.8-0.7-0.6
Pavlov. Cond. lever latency1.31.82.4-1.61.6-1.5-1.11.5-1.3-0.9-1.5-1.3-1.2-1.0
Pavlov. Cond. magazine entry latency1.31.62.51.3-1.51.41.1-1.51.20.21.61.31.31.0
Pavlov. Cond. change in total contacts0.71.01.9-0.91.1-1.1-1.21.0-1.1-1.4-0.9-1.0-0.9-0.8
Pavlov. Cond. index score0.81.11.71.2-1.31.20.8-1.21.00.31.31.11.00.8
Pavlov. Cond. latency score0.81.01.71.3-1.21.10.9-1.20.90.21.31.00.90.7
Pavlov. Cond. lever contacts1.41.92.51.5-1.61.51.2-1.51.40.91.61.41.31.1
Pavlov. Cond. magazine entry number0.50.61.0-0.60.9-0.8-0.50.9-0.70.0-1.0-0.9-0.8-0.7
Pavlov. Cond. intertrial magazine entries1.92.94.80.7-1.71.71.8-1.71.92.21.71.71.61.6
Pavlov. Cond. lever-magazine prob. diff.0.50.71.21.0-1.00.90.6-1.00.80.11.10.90.80.6
Pavlov. Cond. response bias1.41.92.81.2-1.61.51.0-1.61.40.61.71.51.41.2
Time in closed arm before self-admin2.22.94.8-1.21.9-1.9-2.21.7-1.8-1.2-1.5-1.8-1.7-1.5
Time in closed arm after self-admin1.81.92.3-0.61.5-1.5-1.51.5-1.5-1.2-1.4-1.5-1.4-1.4
Time in open arm before self-admin0.90.91.80.90.7-0.8-0.60.8-0.9-1.3-0.9-1.0-1.1-1.3
Time in open arm after self-admin0.10.20.30.6-0.50.50.2-0.50.40.10.40.40.30.2
Bone: periosteal estimation0.91.916.7-4.11.3-0.8-0.30.4-0.5-0.0-0.4-0.10.71.1
Bone: periosteal perimeter1.22.112.5-3.51.7-1.4-0.91.1-1.1-0.6-1.1-0.8-0.10.2
Bone: post-yield work0.50.76.4-2.50.6-0.3-0.10.0-0.2-0.2-0.00.10.60.9
Progressive ratio test 1 active lever presses3.44.210.53.2-2.42.12.1-2.12.01.92.01.71.30.9
Progressive ratio test 1 breakpoint3.74.510.03.2-2.52.22.1-2.22.12.02.11.81.51.0
Progressive ratio test 1 inactive lever presses0.20.21.81.4-0.40.30.3-0.30.20.00.40.20.0-0.1
Progressive ratio test 2 active lever presses0.81.03.31.8-1.00.91.1-1.00.91.00.90.70.60.3
Progressive ratio test 2 breakpoint0.60.73.01.7-0.80.70.9-0.70.60.80.70.50.40.1
Progressive ratio test 2 inactive lever presses1.21.92.31.5-1.41.41.4-1.51.41.51.51.31.21.1
Incentive Sensitization - Responses0.30.40.7-0.40.9-0.7-0.70.7-0.7-0.3-0.8-0.7-0.5-0.4
Incentive Sensitization - Breakpoint0.40.50.9-0.30.9-0.8-0.70.9-0.7-0.3-0.9-0.8-0.6-0.5
Sum of active levers in priming session hrs 5-60.10.10.20.20.2-0.3-0.30.2-0.3-0.5-0.3-0.3-0.4-0.4
Progressive ratio0.30.43.01.7-0.70.50.3-0.40.40.40.40.2-0.0-0.2
Food seeking constrained by brief footshock0.91.15.12.3-1.10.90.8-0.90.90.90.90.70.30.1
Seeking ratio, punishment vs. effort0.00.00.1-0.30.1-0.0-0.00.10.00.0-0.00.00.10.2
Retroperitoneal fat weight2.39.812.81.5-3.53.42.2-3.63.42.63.63.53.23.1
Reaction time number correct0.61.22.2-1.5-0.40.71.2-0.81.01.40.71.01.21.5
Reaction time mean minus median0.51.25.22.3-1.10.91.0-0.60.91.70.60.50.2-0.0
Reaction time mean minus median AUC0.20.52.71.7-0.60.40.4-0.20.51.20.10.1-0.2-0.3
Reaction time num false alarms0.20.32.51.6-0.30.1-0.00.1-0.10.0-0.1-0.1-0.4-0.6
Reaction time num false alarms AUC0.30.52.81.7-0.1-0.2-0.40.4-0.4-0.4-0.3-0.4-0.7-1.0
Reaction time trials correct on left0.61.22.2-1.5-0.40.71.2-0.81.01.40.71.01.21.5
Reaction time trials on left0.61.22.2-1.3-0.50.71.2-0.91.01.40.81.01.21.5
Reaction time mean0.30.51.10.9-0.70.60.9-0.60.71.00.70.50.40.3
Reaction time mean AUC0.20.40.90.6-0.60.50.8-0.50.60.90.60.50.40.3
Median of all reaction times0.20.30.60.2-0.50.50.8-0.60.50.60.70.50.50.5
Reaction time omissions1.42.010.33.2-1.41.21.4-0.91.11.70.90.70.2-0.2
Reaction time false alarm rate1.11.53.51.90.5-0.8-1.11.0-1.1-1.3-0.9-1.1-1.5-1.8
Reaction time premature initiation rate1.31.73.31.8-1.61.51.3-1.21.41.31.11.20.90.8
Reaction time premature initiations1.62.84.10.9-1.81.81.9-1.61.92.01.51.71.51.5
Std. dev. reaction times0.50.95.22.3-0.90.70.7-0.40.71.40.50.3-0.0-0.3
Reaction time trials completed0.61.22.2-1.3-0.50.71.2-0.91.01.40.81.01.21.5
Reaction time trials AUC0.51.02.9-1.7-0.20.51.0-0.70.81.20.60.81.11.4
Run reversals in cocaine runway, females0.30.30.6-0.8-0.30.40.5-0.40.50.60.60.50.70.7
Run reversals in cocaine runway, males1.31.32.10.61.0-1.1-0.91.2-1.0-0.8-1.3-1.3-1.4-1.4
Latency to leave start box in cocaine runway0.70.81.60.00.7-0.8-1.00.8-1.0-1.3-0.8-0.9-1.0-1.1
Latency to leave start box in cocaine runway, F0.60.71.51.10.4-0.6-0.60.6-0.7-1.0-0.7-0.8-1.1-1.2
Latency to leave start box in cocaine runway, M0.70.72.5-1.60.9-0.8-0.80.7-0.8-0.8-0.6-0.6-0.5-0.3
Std. dev. time between licks in bursts0.50.72.91.7-1.00.90.7-0.60.70.40.40.70.50.3
Total sessions with >9 infusions0.81.04.22.0-1.10.91.1-1.00.80.70.80.70.40.1
Short access day 1 total inactive lever presses0.70.93.31.8-1.00.91.0-0.80.90.70.80.70.50.3
Short access day 10 total inactive lever presses0.00.00.1-0.10.3-0.20.10.2-0.2-0.3-0.1-0.2-0.2-0.1
Short access day 1 total infusions1.82.44.01.6-1.61.62.0-1.61.51.81.51.41.31.1
Short access day 10 total infusions0.70.93.31.8-0.90.81.3-0.90.70.91.00.50.30.0
Short access total infusions2.93.76.02.4-2.11.92.4-2.01.92.01.91.61.41.1
Short access day 1 locomotion0.30.41.31.1-0.60.50.8-0.60.50.80.50.40.40.2
Short access day 10 total locomotion0.40.71.41.0-0.80.71.2-0.70.81.10.80.60.60.4
Short access total locomotion0.91.12.01.4-1.21.11.4-1.11.01.00.90.90.80.6
One hour access (0.3 mA shock)0.10.10.3-0.60.2-0.10.3-0.2-0.00.40.20.00.20.2
Compulsive drug intake0.50.71.3-0.50.9-0.9-1.10.8-0.9-0.9-0.7-0.8-0.7-0.6
One hour access (shock baseline)0.10.20.5-0.5-0.10.20.7-0.40.30.60.20.30.40.5
Social response proportion1.41.62.60.1-1.21.31.1-1.41.31.41.61.41.41.4
Social responses0.40.53.82.0-0.60.40.4-0.50.30.50.60.1-0.3-0.5
Social time0.81.11.7-0.5-0.81.01.2-1.01.01.01.31.11.21.3
Soleus weight0.10.32.2-1.50.3-0.2-0.10.2-0.1-0.3-0.20.10.40.6
Bone: stiffness2.84.624.9-5.02.4-2.0-1.81.6-1.8-1.4-1.7-1.2-0.40.2
Tibialis anterior weight8.027.234.0-4.05.8-5.8-5.15.5-5.5-5.2-5.3-5.4-5.0-4.6
Time to tail flick, vehicle, before self-admin0.30.31.81.3-0.40.40.5-0.40.20.40.40.1-0.0-0.2
Time to tail flick, vehicle, after self-admin0.40.50.8-0.60.9-0.8-0.70.5-0.8-0.5-0.4-0.8-0.7-0.7
Time to tail flick, test, before self-admin0.30.30.60.30.4-0.5-0.40.8-0.5-0.3-0.7-0.7-0.8-0.8
Time to tail flick, test, after self-admin0.20.20.3-0.50.6-0.5-0.50.4-0.5-0.3-0.4-0.4-0.2-0.2
Delta time to tail flick, vehicle, before/after SA0.10.10.9-0.90.2-0.1-0.1-0.20.00.20.20.10.20.3
Delta time to tail flick, test, before/after SA0.00.00.1-0.30.10.0-0.1-0.3-0.00.00.30.10.20.3
Tibia length0.82.110.2-3.2-0.10.50.7-1.00.70.31.01.21.82.2
Ambulatory time before self-admin0.50.72.21.5-1.10.91.0-0.70.80.60.50.70.40.2
Ambulatory time after self-admin3.94.65.81.0-2.42.32.2-2.22.32.32.22.32.12.0
Bone: tissue strength0.60.61.9-1.40.8-0.7-1.00.5-0.7-0.9-0.6-0.5-0.3-0.2
Total heroin consumption0.40.51.4-1.2-0.40.50.4-0.50.60.00.40.70.91.0
Bone: trabecular number0.50.95.7-2.40.10.20.2-0.20.40.60.10.61.01.3
Bone: trabecular spacing0.30.41.01.00.3-0.4-0.60.4-0.5-0.9-0.4-0.6-0.8-1.0
Bone: trabecular thickness0.81.01.5-0.91.1-1.1-1.01.2-1.0-0.3-1.2-1.0-0.9-0.8
Bone: trabecular tissue density3.55.16.7-0.32.2-2.3-2.42.2-2.6-2.5-2.2-2.4-2.4-2.5
Water consumed over 24 hours1.21.62.7-0.2-1.21.31.0-1.21.41.11.11.51.61.7
Number of responses in last shaping day0.20.20.30.20.4-0.5-0.40.3-0.5-0.3-0.3-0.5-0.5-0.6