Slc4a8

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Liver	gene expression	Slc4a8	0.04	0.03	1.6e-04	0.03	0.03	0.02	0.02	2.2e-04	6.2e-04	4.7e-03	1.0e-03
2	NAcc	isoform ratio	NM_199497.3	0.02	0.01	7.0e-03	0	0.01	0	0.01	4.5e-02	1.0e-02	6.5e-02	3.1e-02
3	PL	mRNA stability	Slc4a8	0.06	0.03	1.9e-06	0.04	0.04	0.04	0.04	2.5e-05	1.1e-05	2.9e-05	6.5e-05
4	PL	gene expression	Slc4a8	0.04	0.03	3.3e-03	0.03	0.02	0.03	0.02	6.5e-04	1.1e-03	8.3e-04	1.3e-03
5	Adipose	gene expression	Slc4a8	0.19	0.08	0.0e+00	0.21	0.21	0.21	0.22	1.5e-22	2.6e-23	2.3e-23	7.6e-24
6	NAcc	gene expression	Slc4a8	0.03	0.03	1.1e-04	0.02	0.02	0.02	0.02	1.3e-03	1.8e-04	3.0e-04	4.1e-04
7	pVTA	intron excision ratio	chr7_133796166_133799035	0.04	0.03	8.3e-03	0.02	0.01	0.01	0.01	1.3e-02	4.0e-02	8.7e-02	5.9e-02
8	pVTA	gene expression	Slc4a8	0.11	0.07	1.6e-07	0.11	0.09	0.1	0.11	2.3e-09	1.8e-07	4.0e-08	4.3e-09
9	Brain	mRNA stability	Slc4a8	0.25	0.1	0.0e+00	0.25	0.27	0.27	0.26	2.5e-23	1.5e-25	4.4e-25	1.4e-24
10	pVTA	mRNA stability	Slc4a8	0.04	0.03	9.3e-03	0.03	0.03	0.03	0.03	2.5e-03	2.1e-03	2.8e-03	3.4e-03
11	BLA	gene expression	Slc4a8	0.1	0.07	3.7e-03	0.01	0.03	0.03	0.01	1.3e-01	9.0e-03	1.3e-02	6.2e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6	7	8	9	10	11
Bone: apparent density	0.6	1.2	9.7	3.1	0.9	-0.6	0.2	0.5	-0.3	-0.4	0.6	-0.1	0.5	0.9
Area under the delay curve	0.2	0.3	0.5	0.7	0.5	-0.4	0.6	0.6	-0.5	0.6	0.6	-0.3	-0.2	-0.1
BMI with tail	1.6	5.7	28.7	5.4	2.6	-2.3	2.5	1.4	-1.9	2.4	1.3	-1.4	-0.7	-0.1
BMI without tail	0.2	1.2	7.7	2.8	1.3	-1.0	0.7	0.6	-0.7	0.9	0.4	-0.6	-0.2	0.1
Body weight	1.0	4.3	32.9	5.7	2.0	-1.5	1.5	0.8	-1.2	1.4	0.6	-0.6	0.3	1.0
Weight adjusted by age	1.2	3.5	4.7	0.9	1.9	-1.9	2.2	2.0	-1.9	1.9	2.0	-1.9	-1.9	-1.8
Bone surface	0.9	1.8	16.2	4.0	1.1	-0.7	0.5	0.3	-0.4	0.2	0.4	-0.0	0.6	1.1
Bone volume	0.8	1.6	13.4	3.7	1.3	-0.9	0.5	0.6	-0.6	0.1	0.7	-0.3	0.3	0.7
Breakpoint value in progressive ratio session	0.1	0.2	1.0	1.0	0.0	0.1	-0.2	-0.1	0.2	0.1	0.1	0.3	0.4	0.6
Number of licking bursts	0.2	0.5	3.0	-1.7	-0.0	-0.1	0.1	0.4	-0.4	0.8	0.3	-0.4	-0.6	-0.8
Context. condit. distance diff. score	0.3	0.3	1.2	1.1	-0.2	0.3	-0.4	-0.4	0.4	-0.2	-0.4	0.5	0.7	0.8
Locomotion velocity, session 1	0.7	0.8	3.3	-1.8	-1.2	1.0	-0.2	-0.8	0.9	-0.7	-0.8	0.8	0.4	0.2
Locomotion distance, session 1	0.3	0.4	3.6	-1.9	-0.6	0.4	0.0	-0.3	0.3	-0.3	-0.3	0.1	-0.3	-0.5
Locomotion velocity, session 2	0.3	0.4	0.6	-0.7	-0.8	0.8	-0.4	-0.6	0.7	-0.7	-0.5	0.7	0.5	0.5
Locomotion distance, session 2	0.6	0.9	6.0	-2.5	-1.0	0.7	-0.4	-0.7	0.6	-0.7	-0.6	0.4	0.0	-0.3
Locomotion velocity, session 3	2.7	3.1	6.3	-2.5	-2.0	1.9	-2.0	-1.8	1.7	-1.6	-1.8	1.5	1.2	0.9
Locomotion distance, session 3	3.9	4.4	7.6	-1.8	-2.1	2.2	-2.7	-1.9	2.2	-2.8	-1.9	2.0	1.8	1.6
Stereotopy head waving bouts, day 3	1.9	2.3	3.9	-0.4	1.3	-1.5	1.6	1.3	-1.6	2.0	1.2	-1.6	-1.7	-1.8
Stereotopy head waving duration, day 3	0.2	0.3	0.8	-0.8	0.1	-0.3	0.4	0.1	-0.5	0.9	-0.1	-0.4	-0.5	-0.7
Locomotion velocity, session 7	2.7	3.0	4.7	-1.8	-1.8	1.7	-2.2	-1.8	1.8	-2.1	-1.8	1.5	1.3	1.1
Locomotion distance, session 7	3.6	4.6	5.8	-2.2	-2.4	2.3	-2.2	-2.2	2.3	-2.2	-2.2	2.1	1.8	1.6
Stereotopy head waving bouts, day 7	4.2	4.9	5.9	1.1	2.4	-2.4	2.0	2.4	-2.4	1.9	2.3	-2.4	-2.4	-2.2
Stereotopy head waving duration, day 7	2.7	3.3	4.0	1.1	2.0	-2.0	1.7	1.9	-2.0	1.7	1.8	-2.0	-1.9	-1.8
Locomotion velocity, session 8	0.0	0.0	0.2	-0.4	-0.2	0.1	-0.3	-0.1	0.2	-0.2	-0.2	0.1	-0.1	-0.1
Locomotion distance, session 8	0.7	1.0	1.5	-0.8	-1.2	1.1	-0.8	-1.1	1.1	-0.9	-1.0	1.1	0.9	0.8
Degree of sensitization distance	0.4	0.5	1.4	0.2	0.5	-0.6	1.2	0.4	-0.6	1.2	0.3	-0.5	-0.6	-0.6
Degree of sensitization stereotypy	3.4	3.8	4.8	1.3	2.2	-2.1	1.8	2.2	-2.0	1.5	2.2	-2.1	-2.0	-1.8
Conditioned locomotion	0.3	0.4	0.8	-0.8	-0.7	0.6	-0.9	-0.6	0.6	-0.5	-0.6	0.5	0.5	0.4
Cocaine response after cond. corrected	0.2	0.2	0.5	-0.3	0.4	-0.5	0.6	0.3	-0.6	0.5	0.4	-0.5	-0.6	-0.7
Cocaine response after cond. not corrected	0.0	0.1	0.3	-0.6	-0.1	-0.0	0.0	-0.1	-0.1	-0.2	0.0	-0.1	-0.2	-0.3
Cocaine response before conditioning	1.5	1.9	2.5	-1.1	-1.5	1.5	-1.3	-1.4	1.5	-1.6	-1.3	1.4	1.2	1.1
Saline control response	0.5	0.7	1.6	-0.2	-0.7	0.7	-1.1	-0.8	0.8	-1.3	-0.9	0.7	0.8	0.8
Bone: connectivity density	0.4	0.7	5.0	2.2	0.2	0.1	-0.1	-0.1	0.3	-0.4	-0.1	0.5	0.8	1.1
Bone: cortical apparent density	1.2	1.9	3.8	-0.7	1.1	-1.4	1.3	1.2	-1.5	1.3	1.1	-1.6	-1.7	-1.9
Bone: cortical area	0.7	1.2	9.2	3.0	1.1	-0.8	0.6	0.5	-0.6	0.2	0.6	-0.3	0.2	0.5
Bone: cortical porosity	0.9	1.0	1.5	0.2	-0.9	1.0	-1.0	-1.0	1.0	-1.2	-0.9	1.1	1.2	1.2
Bone: cortical porosity	1.2	1.4	2.0	-0.0	-1.1	1.1	-1.2	-1.2	1.2	-1.4	-1.1	1.2	1.3	1.3
Bone: cortical thickness	0.3	0.5	3.5	1.9	0.8	-0.6	0.6	0.4	-0.5	0.4	0.4	-0.3	-0.0	0.2
Bone: cortical thickness	0.7	0.9	2.8	-0.4	-0.8	0.8	-1.0	-0.8	0.9	-1.7	-0.9	0.8	0.8	0.8
Bone: cortical tissue density	1.1	1.7	3.6	-0.8	1.0	-1.3	1.2	1.2	-1.4	1.2	1.0	-1.5	-1.7	-1.9
Condit. Reinf. active minus inactive responses	0.0	0.0	0.2	0.4	0.2	-0.2	0.5	0.1	-0.1	-0.0	0.1	-0.1	-0.2	-0.1
Condit. Reinf. active-inactive response ratio	0.2	0.2	0.5	0.7	-0.2	0.3	-0.3	-0.4	0.4	-0.5	-0.4	0.5	0.5	0.6
Condit. Reinf. active responses	0.1	0.1	0.4	-0.3	0.0	-0.1	0.6	0.2	-0.1	0.1	0.2	-0.2	-0.4	-0.4
Condit. Reinf. inactive responses	0.4	0.5	2.9	-1.7	-0.1	-0.1	0.6	0.2	-0.2	0.3	0.3	-0.4	-0.7	-0.9
Incentive salience index mean	0.4	0.5	1.2	0.8	0.7	-0.7	1.1	0.7	-0.6	0.6	0.8	-0.6	-0.6	-0.4
Condit. Reinf. lever presses	1.3	2.0	3.6	1.2	1.4	-1.4	1.9	1.5	-1.3	1.5	1.6	-1.2	-1.2	-1.0
Condit. Reinf. active minus inactive responses	0.4	0.7	1.6	1.3	0.9	-0.9	1.0	0.7	-0.8	0.9	0.6	-0.7	-0.5	-0.4
Condit. Reinf. active-inactive response ratio	0.1	0.2	0.9	1.0	0.5	-0.4	0.4	0.1	-0.4	0.5	0.1	-0.3	-0.1	-0.1
Condit. Reinf. active responses	0.2	0.3	0.5	0.6	0.7	-0.7	0.6	0.6	-0.6	0.3	0.5	-0.6	-0.6	-0.5
Condit. Reinf. inactive responses	0.1	0.1	0.2	-0.4	0.1	-0.2	0.3	0.3	-0.1	-0.3	0.3	-0.3	-0.4	-0.5
Condit. Reinf. lever presses	0.7	1.1	1.5	-0.3	-1.0	1.1	-1.0	-1.2	1.1	-0.7	-1.2	1.1	1.2	1.1
Condit. Reinf. lever reinforcers received	0.0	0.0	0.1	0.3	0.2	-0.2	0.2	0.1	-0.1	-0.0	-0.0	-0.1	-0.1	-0.1
Conditioned reinforcement - actives	0.2	0.7	1.8	-1.4	-0.9	0.8	-1.1	-0.8	0.8	-0.9	-0.7	0.6	0.5	0.4
Conditioned reinforcement - inactives	0.8	2.1	6.8	-2.6	-1.5	1.4	-1.6	-1.2	1.3	-1.7	-1.0	1.1	0.7	0.5
Conditioned locomotion	0.6	0.8	1.2	-0.8	-1.0	1.0	-1.1	-1.1	0.9	-0.4	-1.0	0.9	0.9	0.8
Patch foraging indifference point 0 sec	0.8	2.3	5.7	-2.4	-1.7	1.5	-1.9	-1.1	1.6	-1.7	-1.4	1.2	0.8	0.6
Patch foraging indifference point AUC	0.2	0.5	1.1	-1.1	0.3	-0.4	0.4	0.8	-0.6	0.8	0.8	-0.7	-0.9	-1.0
Delay disc. indifference point, 0s delay	0.2	0.2	1.2	1.1	0.5	-0.3	0.3	0.5	-0.4	0.6	0.5	-0.2	0.0	0.2
Delay disc. indifference point, 16s delay	0.1	0.1	0.5	0.7	0.2	-0.1	0.2	0.1	-0.0	0.2	0.1	0.1	0.2	0.3
Delay disc. indifference point, 2s delay	4.7	5.2	6.4	1.4	2.5	-2.5	2.3	2.4	-2.5	2.1	2.2	-2.4	-2.3	-2.2
Delay disc. indifference point, 24s delay	0.1	0.2	1.1	0.6	0.3	-0.3	0.8	0.2	-0.4	1.1	0.1	-0.2	-0.1	-0.1
Delay disc. indifference point, 4s delay	0.3	0.3	0.8	0.9	0.6	-0.6	0.5	0.7	-0.5	0.5	0.7	-0.4	-0.2	-0.1
Delay disc. indifference point, 8s delay	0.1	0.2	0.7	0.7	-0.2	0.4	-0.3	-0.2	0.4	-0.3	-0.3	0.5	0.8	0.8
Indifference point function ln k	0.3	0.8	6.8	2.6	0.8	-0.6	0.5	0.2	-0.4	0.3	0.2	-0.1	0.3	0.5
Indifference point function log k	0.3	0.8	6.8	2.6	0.8	-0.6	0.5	0.2	-0.4	0.3	0.2	-0.1	0.3	0.5
Patch foraging total patch changes 0 sec	1.0	3.0	5.7	-2.4	-1.9	1.8	-2.2	-1.4	1.8	-1.9	-1.7	1.4	1.1	0.9
Patch foraging total patch changes 12 sec	0.7	1.0	5.5	-2.4	-1.2	0.9	-0.9	-0.5	0.9	-0.5	-0.6	0.6	0.2	-0.1
Patch foraging total patch changes 18 sec	0.6	1.5	7.5	-2.7	-1.3	1.2	-1.2	-0.6	1.1	-1.2	-0.8	0.7	0.3	0.0
Patch foraging total patch changes 24 sec	0.3	0.9	3.9	-2.0	-1.1	0.9	-1.1	-0.4	1.0	-1.0	-0.5	0.6	0.3	0.2
Patch foraging total patch changes 6 sec	0.8	1.4	7.5	-2.7	-1.3	1.1	-1.1	-0.7	1.0	-0.9	-0.9	0.7	0.2	-0.1
Patch foraging time to switch 0 sec	0.1	0.4	2.8	-1.7	-0.1	-0.0	-0.2	0.2	-0.0	-0.2	0.1	-0.4	-0.6	-0.8
Patch foraging water rate 0 sec	0.2	0.7	6.2	2.5	0.4	-0.2	0.5	-0.2	-0.1	0.4	-0.1	0.2	0.6	0.9
Patch foraging water rate 12 sec	0.1	0.5	3.4	1.8	0.1	0.1	-0.1	-0.1	0.2	-0.2	-0.1	0.4	0.7	1.0
Patch foraging water rate 18 sec	0.0	0.0	0.3	0.5	0.0	-0.0	0.0	-0.1	-0.1	-0.0	-0.1	0.1	0.2	0.2
Patch foraging water rate 24 sec	0.5	0.8	4.9	2.2	0.9	-0.7	0.7	0.5	-0.6	0.8	0.5	-0.4	0.0	0.2
Patch foraging water rate 6 sec	0.7	1.0	8.1	2.8	0.7	-0.4	0.2	0.3	-0.3	0.5	0.5	0.1	0.5	0.9
Seeking ratio, delayed vs. immediate footshock	0.1	0.1	0.5	0.7	0.3	-0.2	0.7	0.3	-0.2	0.5	0.3	-0.1	-0.0	0.1
Distance traveled before self-admin	0.2	0.4	1.4	-1.2	-0.8	0.6	-0.8	-0.5	0.6	-0.6	-0.4	0.4	0.2	0.0
Distance traveled after self-admin	2.2	3.8	4.8	-0.6	-2.2	2.1	-1.7	-2.2	2.1	-1.9	-2.2	2.1	2.0	1.8
Extensor digitorum longus weight	6.0	23.8	31.3	4.8	5.6	-5.4	4.7	5.1	-5.1	4.9	4.9	-4.9	-4.3	-3.8
Bone: elastic displacement	3.3	4.2	8.7	-2.9	-2.5	2.2	-1.7	-2.3	2.0	-1.7	-2.2	1.9	1.5	1.1
Bone: elastic work	1.7	2.3	3.5	-0.7	-1.7	1.7	-1.1	-1.9	1.5	-1.1	-1.8	1.7	1.6	1.5
Bone: endosteal estimation	0.6	1.4	12.2	3.5	0.8	-0.4	0.0	0.1	-0.2	-0.2	0.1	0.2	0.9	1.3
Bone: endosteal perimeter	0.6	1.4	10.8	3.3	1.3	-0.9	0.4	0.8	-0.7	0.3	0.8	-0.4	0.2	0.6
Epididymis fat weight	1.3	6.8	11.3	0.9	-2.4	2.6	-1.9	-2.8	2.7	-2.1	-2.7	3.0	3.2	3.4
Delta time in closed arm before/after self-admin	0.2	0.2	0.3	0.3	-0.3	0.3	-0.6	-0.3	0.4	-0.2	-0.3	0.4	0.5	0.5
Delta time in open arm before/after self-admin	2.3	2.7	3.5	-0.9	-1.9	1.8	-1.5	-1.6	1.8	-1.9	-1.6	1.8	1.6	1.5
Diff in mean of infusions in LGA sessions	0.6	1.2	2.3	1.5	1.2	-1.1	1.0	1.1	-0.9	1.2	1.3	-0.9	-0.8	-0.6
Delay discount exponential model param	0.3	0.4	0.6	-0.7	-0.6	0.6	-0.7	-0.8	0.6	-0.7	-0.7	0.5	0.3	0.2
Extinction: sum of active levers before priming	1.3	1.9	4.8	2.2	1.4	-1.3	1.5	1.3	-1.2	1.8	1.4	-1.0	-0.8	-0.6
Active lever presses in extinction session 6	0.6	0.6	1.0	0.3	-0.7	0.7	-0.6	-1.0	0.7	-0.9	-0.8	0.8	0.9	0.9
Bone: final force	1.2	2.0	17.7	4.2	0.9	-0.4	0.6	-0.0	-0.2	0.1	0.1	0.3	1.0	1.5
Bone: final moment	1.4	2.2	18.9	4.3	0.8	-0.3	0.4	-0.2	-0.1	-0.0	-0.1	0.5	1.2	1.7
Food consumed during 24 hour testing period	0.5	1.1	3.2	1.8	-0.5	0.7	0.2	-1.0	0.8	-0.0	-0.8	1.1	1.3	1.6
Glucose	0.1	0.1	0.2	-0.4	-0.4	0.4	-0.0	-0.3	0.4	-0.3	-0.4	0.3	0.2	0.2
Heart weight	0.6	1.0	1.9	0.7	-0.7	0.8	-1.1	-0.9	0.9	-1.4	-0.9	1.0	1.2	1.3
Delay discount hyperbolic model param	0.4	0.5	0.8	-0.7	-0.8	0.7	-0.7	-0.9	0.7	-0.7	-0.8	0.6	0.5	0.4
Intermittent access intake day 1-15 change	0.3	1.6	2.5	0.1	-1.1	1.2	-1.0	-1.4	1.3	-1.4	-1.4	1.4	1.5	1.6
Intermittent access intake escalation	0.1	0.7	1.4	0.5	-0.6	0.7	-0.6	-0.8	0.8	-0.9	-0.8	0.9	1.1	1.2
Intermittent access intake escalation 2	0.4	0.7	1.2	0.3	-0.7	0.8	-0.7	-0.8	0.8	-1.0	-0.8	0.9	1.0	1.1
Intermitt. access day 1 inactive lever presses	0.0	0.1	0.3	-0.5	0.1	-0.2	0.3	-0.1	-0.2	0.6	-0.3	-0.3	-0.4	-0.4
Intermitt. access day 15 inactive lever presses	0.0	0.2	0.4	-0.0	-0.4	0.3	-0.7	-0.4	0.3	-0.4	-0.6	0.3	0.3	0.2
Intermitt. access escalation Index	0.9	2.9	3.5	0.3	1.6	-1.6	1.9	1.8	-1.7	1.8	1.8	-1.8	-1.9	-1.8
Intermittent access day 1 total infusions	0.3	1.0	2.4	-1.6	-1.0	0.9	-1.4	-1.0	0.9	-0.9	-1.0	0.7	0.5	0.3
Intermittent access day 15 total infusions	0.4	1.0	1.7	-0.9	-1.0	1.0	-1.3	-1.1	1.0	-1.0	-1.1	0.9	0.8	0.7
Intermittent access terminal intake (last 3 days)	0.5	0.9	1.8	-1.0	-0.9	0.9	-1.3	-1.1	0.9	-1.1	-1.1	0.8	0.7	0.5
Intermittent access total infusions	0.9	1.1	2.0	-1.4	-1.0	1.0	-1.4	-1.1	0.9	-1.1	-1.1	0.8	0.7	0.5
Intermittent access day 1 locomotion	0.9	1.6	2.5	-1.6	-1.4	1.3	-1.5	-1.4	1.2	-1.0	-1.4	1.1	1.0	0.8
Intermittent access day 15 total locomotion	1.3	4.8	5.6	-1.3	-2.2	2.3	-2.4	-2.2	2.3	-2.3	-2.2	2.3	2.3	2.2
Intermittent access total locomotion	2.9	3.5	5.3	-2.3	-2.0	1.9	-2.1	-1.9	1.8	-1.8	-1.9	1.7	1.5	1.3
Intermittent access standard deviation	0.7	3.4	4.4	-0.2	-1.8	1.9	-2.0	-2.0	1.9	-2.1	-2.1	1.9	1.9	1.9
Left kidney weight	0.1	1.0	8.7	2.9	0.9	-0.6	0.5	0.4	-0.4	0.1	0.5	-0.1	0.3	0.7
Right kidney weight	0.5	3.8	24.0	4.9	2.1	-1.6	1.5	1.4	-1.3	1.1	1.5	-0.9	-0.2	0.4
Cocaine induced anxiety	0.1	0.3	2.4	1.6	0.2	-0.0	-0.1	-0.2	0.1	-0.3	-0.1	0.3	0.6	0.8
Post-drug Anxiety	0.6	0.6	2.4	1.6	-0.1	0.3	-0.5	-0.6	0.5	-0.5	-0.5	0.7	1.0	1.3
Baseline Anxiety	0.1	0.2	0.8	0.2	0.4	-0.4	0.4	0.4	-0.4	0.9	0.4	-0.3	-0.3	-0.2
Tail length	0.1	0.8	2.5	-0.1	-0.6	0.7	-1.6	-0.5	0.8	-1.2	-0.7	0.8	0.9	0.9
Length with tail	0.2	0.7	5.6	2.4	0.4	-0.2	-0.3	0.1	-0.0	-0.1	-0.1	0.2	0.8	1.0
Length without tail	0.4	2.1	16.6	4.1	1.2	-0.8	0.9	0.6	-0.7	0.8	0.5	-0.2	0.5	1.0
Times rat made contact with spout	0.2	0.3	0.7	0.4	-0.5	0.6	-0.0	-0.4	0.6	-0.1	-0.4	0.7	0.7	0.8
Lifetime Intake	1.8	2.2	3.7	-1.8	-1.6	1.5	-1.9	-1.6	1.4	-1.5	-1.6	1.3	1.1	0.8
Liver weight, left	1.0	1.8	15.5	3.9	1.0	-0.5	0.1	-0.1	-0.3	0.1	-0.0	0.1	0.9	1.3
Liver weight, right	0.5	0.9	4.6	2.2	0.0	0.3	-0.5	-0.6	0.4	-0.6	-0.7	0.7	1.1	1.3
Locomotor activity	0.2	0.3	1.2	-1.1	-0.6	0.5	-0.1	-0.5	0.5	-0.7	-0.6	0.4	0.2	0.1
Locomotor testing distance	0.4	1.0	3.4	-1.9	-1.1	1.0	-0.6	-0.9	0.9	-1.1	-1.1	0.7	0.3	0.2
Locomotor testing rearing	0.4	1.6	3.6	-1.1	-1.3	1.3	-1.4	-1.1	1.4	-1.9	-1.2	1.1	0.9	0.9
Locomotion in novel chamber	0.8	1.0	3.6	1.9	1.3	-1.1	0.6	0.9	-1.0	1.0	0.8	-0.8	-0.4	-0.1
Locomotion in novel chamber post-restriction	0.2	0.6	1.0	0.1	-0.7	0.7	-0.5	-0.9	0.7	-0.5	-0.8	0.9	1.0	1.0
Fecal boli incidents, locomotor time 1	1.0	2.7	4.1	-0.8	-1.8	1.8	-1.2	-2.0	1.7	-1.3	-2.0	1.8	1.7	1.6
Change in fecal boli incidents, locomotor task	0.9	0.9	1.4	-0.1	1.0	-1.0	0.8	1.0	-1.1	0.6	1.1	-1.1	-1.1	-1.2
Time >=10cm from walls, locomotor time 1	0.5	0.6	1.0	-1.0	-0.9	0.8	-0.6	-0.9	0.7	-0.6	-1.0	0.7	0.6	0.4
Bouts of movement, locomotor time 1	0.2	0.2	0.6	-0.2	0.3	-0.3	0.7	0.4	-0.5	0.8	0.5	-0.4	-0.4	-0.5
Total resting periods, locomotor time 1	0.1	0.1	0.9	-0.9	-0.2	0.1	0.3	0.0	-0.1	0.2	0.1	-0.1	-0.3	-0.4
Rest time, locomotor task time 1	0.2	0.3	1.4	-1.2	-0.6	0.5	-0.4	-0.4	0.3	-0.8	-0.4	0.3	0.2	-0.0
Distance moved, locomotor task time 1	0.1	0.2	0.3	-0.1	0.4	-0.4	0.3	0.3	-0.5	0.5	0.4	-0.5	-0.5	-0.5
Vertical activity count, locomotor time 1	0.1	0.8	1.8	1.3	1.1	-1.0	0.7	0.8	-0.8	0.8	0.9	-0.8	-0.7	-0.5
Time >=10cm from walls, locomotor time 2	0.2	0.5	0.9	-0.9	-0.7	0.7	-0.8	-0.8	0.6	-0.8	-1.0	0.6	0.5	0.3
Bouts of movement, locomotor time 2	0.3	1.1	3.8	1.9	1.2	-1.1	0.9	1.0	-1.0	1.1	0.9	-0.8	-0.5	-0.3
Total resting periods, locomotor time 2	0.4	1.7	4.3	2.1	1.5	-1.4	1.2	1.4	-1.3	1.2	1.3	-1.1	-0.8	-0.6
Rest time, locomotor task time 2	0.1	0.1	0.4	-0.6	0.1	-0.1	-0.0	0.2	-0.2	-0.3	0.3	-0.3	-0.3	-0.4
Distance moved, locomotor task time 2	0.1	0.1	0.3	-0.2	0.2	-0.2	0.4	0.1	-0.2	0.6	0.1	-0.3	-0.3	-0.4
Vertical activity count, locomotor time 2	0.1	0.2	0.4	0.6	0.3	-0.3	0.7	0.4	-0.3	0.7	0.3	-0.2	-0.2	-0.1
Light reinforcement 1	0.1	0.3	2.5	-1.6	-0.3	0.1	-0.1	0.1	-0.1	0.5	0.2	-0.2	-0.4	-0.6
Light reinforcement 2	0.1	0.3	1.1	-0.0	0.4	-0.3	0.3	0.9	-0.4	0.7	1.1	-0.4	-0.4	-0.3
Bone: marrow area	0.6	1.4	11.5	3.4	0.7	-0.3	-0.0	0.1	-0.1	-0.3	0.0	0.3	0.9	1.3
Bone: maximum diameter	0.2	0.3	2.5	1.6	0.7	-0.5	0.1	0.4	-0.4	-0.0	0.3	-0.3	0.1	0.3
Bone: maximum force	1.5	3.0	21.8	4.7	1.7	-1.3	1.4	0.8	-1.1	0.8	0.9	-0.5	0.3	0.8
Bone: maximum moment	1.5	2.8	22.9	4.8	1.5	-1.1	1.1	0.5	-0.9	0.7	0.6	-0.3	0.5	1.1
Mean time between licks in bursts	0.1	0.6	1.5	-1.2	-0.9	0.8	-0.4	-1.0	0.5	0.1	-1.0	0.7	0.5	0.3
Mean num. licks in bursts	0.5	1.4	2.7	1.6	-0.7	0.9	-0.6	-1.1	1.2	-1.4	-1.1	1.2	1.4	1.6
Cd content in liver	0.3	0.3	0.6	-0.7	-0.6	0.5	-0.8	-0.7	0.5	0.1	-0.8	0.5	0.4	0.3
Co content in liver	0.1	0.2	0.5	0.2	0.4	-0.4	0.3	0.6	-0.2	0.2	0.7	-0.4	-0.4	-0.3
Cu content in liver	0.2	0.3	0.8	0.6	-0.1	0.3	-0.8	0.1	0.5	-0.9	0.0	0.4	0.5	0.6
Fe content in liver	0.6	0.8	3.3	-1.8	-0.8	0.7	-1.4	-0.5	0.6	-0.9	-0.7	0.4	0.2	0.0
K content in liver	0.0	0.0	0.3	-0.0	0.0	0.0	0.0	0.2	0.1	-0.6	0.1	-0.0	-0.1	-0.0
Mg content in liver	0.2	0.2	0.4	-0.3	-0.5	0.5	-0.1	-0.5	0.5	-0.6	-0.6	0.5	0.4	0.4
Mn content in liver	0.4	0.5	1.3	0.2	0.6	-0.6	1.1	0.7	-0.6	0.4	0.9	-0.6	-0.7	-0.6
Na content in liver	0.1	0.1	0.4	0.5	0.0	0.1	-0.4	0.4	0.3	-0.6	0.3	0.2	0.2	0.4
Rb content in liver	0.8	0.9	1.2	-0.9	-1.0	0.9	-1.1	-1.0	1.0	-1.1	-1.1	0.8	0.7	0.6
Se content in liver	0.9	1.1	3.8	-2.0	-1.2	1.1	-1.0	-1.0	1.0	-0.9	-1.0	0.8	0.5	0.3
Sr content in liver	0.2	0.2	0.5	0.7	-0.1	0.2	-0.5	-0.0	0.3	-0.5	0.1	0.3	0.4	0.6
Zn content in liver	1.1	1.2	1.6	-1.2	-1.3	1.2	-1.2	-1.2	1.1	-0.9	-1.2	1.1	1.0	0.8
Bone: minimum diameter	0.8	1.5	10.4	3.2	1.4	-1.0	0.6	0.8	-0.9	0.7	0.8	-0.5	0.1	0.4
Time in familiar zone, hab. session 1	0.1	0.1	0.8	0.4	0.1	-0.2	0.9	-0.1	-0.2	0.6	0.0	-0.0	-0.1	-0.1
Time in novel zone, hab. session 1	0.2	0.2	0.4	-0.4	0.5	-0.4	-0.2	0.6	-0.5	0.2	0.5	-0.6	-0.5	-0.6
Total zone transitions, hab. session 1	2.0	2.8	4.0	-0.1	1.5	-1.6	1.9	1.7	-1.7	1.5	1.7	-1.8	-2.0	-2.0
Total locomotion distance, hab. session 1	0.1	0.2	0.5	-0.7	0.0	-0.1	0.6	0.0	-0.3	0.2	0.0	-0.3	-0.5	-0.6
Locomotion velocity, hab. session 1	0.1	0.1	0.3	-0.6	0.0	-0.1	0.6	0.0	-0.3	0.3	-0.0	-0.2	-0.4	-0.5
Time in familiar zone, hab. session 2	0.4	0.4	2.8	1.7	0.1	-0.0	0.5	-0.3	0.1	0.6	-0.1	0.3	0.5	0.7
Time in novel zone, hab. session 2	0.4	0.4	2.9	-1.7	-0.0	-0.1	-0.5	0.3	-0.2	-0.4	0.1	-0.5	-0.6	-0.9
Total zone transitions, hab. session 2	0.1	0.1	0.6	-0.8	-0.1	0.0	0.1	0.1	-0.1	-0.2	0.2	-0.2	-0.3	-0.3
Total locomotion distance, hab. session 2	0.2	0.3	1.4	-1.2	-0.5	0.4	-0.3	-0.4	0.3	-0.5	-0.4	0.2	0.1	-0.0
Locomotion velocity, hab. session 2	0.2	0.3	1.0	-1.0	-0.6	0.6	-0.4	-0.5	0.4	-0.6	-0.5	0.4	0.3	0.2
Novel to familiar place preference ratio	1.8	2.4	3.2	1.3	1.8	-1.7	1.3	1.7	-1.6	1.5	1.6	-1.6	-1.4	-1.3
Novelty place preference	1.5	2.0	2.6	1.1	1.6	-1.5	1.2	1.5	-1.5	1.4	1.5	-1.5	-1.3	-1.2
Time in novel zone, NPP test	1.7	2.1	2.6	0.9	1.6	-1.5	1.2	1.5	-1.5	1.5	1.5	-1.5	-1.4	-1.3
Total zone transitions, NPP test	0.4	0.6	5.0	-2.2	-0.4	0.2	0.1	0.2	0.0	-0.3	0.2	-0.2	-0.5	-0.8
Total locomotion distance, NPP test	0.8	1.2	7.6	-2.8	-1.3	1.0	-0.6	-0.7	0.7	-0.7	-0.7	0.6	0.2	-0.1
Locomotion velocity, NPP test	0.7	1.0	5.6	-2.4	-1.3	1.1	-0.6	-0.7	0.8	-0.8	-0.7	0.7	0.4	0.1
Intraocular pressure	1.9	3.1	6.0	-2.4	-2.1	1.8	-1.7	-1.8	1.8	-1.5	-1.9	1.6	1.2	0.9
Delta distance traveled before/after self-admin	4.6	5.0	6.9	0.5	-2.2	2.3	-1.8	-2.4	2.3	-2.3	-2.4	2.5	2.6	2.6
Delta ambulatory time before/after self-admin	2.9	4.9	6.3	0.2	-2.1	2.2	-1.8	-2.4	2.3	-2.5	-2.4	2.4	2.5	2.5
Parametrial fat weight	1.1	2.5	4.0	-0.9	-1.9	1.7	-0.4	-2.0	1.7	-0.7	-2.0	1.8	1.7	1.5
Pavlov. Cond. lever latency	1.2	1.5	2.4	-1.1	-1.3	1.2	-1.5	-1.4	1.1	-1.3	-1.4	1.1	1.1	0.8
Pavlov. Cond. magazine entry latency	1.5	1.9	2.6	1.6	1.6	-1.5	1.3	1.5	-1.4	1.4	1.4	-1.3	-1.1	-1.0
Pavlov. Cond. change in total contacts	3.0	3.2	4.3	1.9	2.0	-1.9	2.1	1.9	-1.8	1.8	1.8	-1.7	-1.5	-1.3
Pavlov. Cond. index score	2.9	3.7	4.9	1.9	2.2	-2.0	2.0	2.2	-1.8	1.8	2.2	-1.8	-1.7	-1.4
Pavlov. Cond. latency score	2.6	3.3	4.3	1.8	2.0	-1.9	1.9	2.1	-1.7	1.7	2.0	-1.7	-1.6	-1.3
Pavlov. Cond. lever contacts	1.2	1.4	2.0	1.1	1.3	-1.2	1.4	1.4	-1.0	1.1	1.4	-1.1	-1.0	-0.8
Pavlov. Cond. magazine entry number	1.0	1.2	1.8	-1.3	-1.3	1.2	-1.1	-1.2	1.1	-1.1	-1.1	1.0	0.9	0.7
Pavlov. Cond. intertrial magazine entries	1.6	1.9	5.4	-2.3	-1.8	1.5	-1.0	-1.4	1.4	-1.1	-1.3	1.2	0.8	0.6
Pavlov. Cond. lever-magazine prob. diff.	3.0	3.7	4.7	2.0	2.1	-2.0	2.1	2.2	-1.8	1.8	2.2	-1.8	-1.6	-1.3
Pavlov. Cond. response bias	0.7	0.8	1.0	1.0	1.0	-0.9	1.0	1.0	-0.9	0.9	1.0	-0.8	-0.7	-0.6
Pavlov. Cond. lever latency	1.3	1.8	2.4	1.6	1.6	-1.5	1.1	1.5	-1.3	0.9	1.5	-1.3	-1.2	-1.0
Pavlov. Cond. magazine entry latency	1.1	1.6	2.5	-1.3	-1.5	1.4	-1.1	-1.5	1.2	-0.2	-1.6	1.3	1.3	1.0
Pavlov. Cond. change in total contacts	0.4	1.0	1.9	0.9	1.1	-1.1	1.2	1.0	-1.1	1.4	0.9	-1.0	-0.9	-0.8
Pavlov. Cond. index score	0.7	1.1	1.7	-1.2	-1.3	1.2	-0.8	-1.2	1.0	-0.3	-1.3	1.1	1.0	0.8
Pavlov. Cond. latency score	0.6	1.0	1.7	-1.3	-1.2	1.1	-0.9	-1.2	0.9	-0.2	-1.3	1.0	0.9	0.7
Pavlov. Cond. lever contacts	1.3	1.9	2.5	-1.5	-1.6	1.5	-1.2	-1.5	1.4	-0.9	-1.6	1.4	1.3	1.1
Pavlov. Cond. magazine entry number	0.5	0.6	1.0	0.6	0.9	-0.8	0.5	0.9	-0.7	-0.0	1.0	-0.9	-0.8	-0.7
Pavlov. Cond. intertrial magazine entries	1.3	2.9	4.8	-0.7	-1.7	1.7	-1.8	-1.7	1.9	-2.2	-1.7	1.7	1.6	1.6
Pavlov. Cond. lever-magazine prob. diff.	0.5	0.7	1.2	-1.0	-1.0	0.9	-0.6	-1.0	0.8	-0.1	-1.1	0.9	0.8	0.6
Pavlov. Cond. response bias	1.4	1.9	2.8	-1.2	-1.6	1.5	-1.0	-1.6	1.4	-0.6	-1.7	1.5	1.4	1.2
Time in closed arm before self-admin	1.7	2.9	4.8	1.2	1.9	-1.9	2.2	1.7	-1.8	1.2	1.5	-1.8	-1.7	-1.5
Time in closed arm after self-admin	1.7	1.9	2.3	0.6	1.5	-1.5	1.5	1.5	-1.5	1.2	1.4	-1.5	-1.4	-1.4
Time in open arm before self-admin	0.8	0.9	1.8	-0.9	0.7	-0.8	0.6	0.8	-0.9	1.3	0.9	-1.0	-1.1	-1.3
Time in open arm after self-admin	0.1	0.2	0.3	-0.6	-0.5	0.5	-0.2	-0.5	0.4	-0.1	-0.4	0.4	0.3	0.2
Bone: periosteal estimation	0.8	1.9	16.7	4.1	1.3	-0.8	0.3	0.4	-0.5	0.0	0.4	-0.1	0.7	1.1
Bone: periosteal perimeter	1.1	2.1	12.5	3.5	1.7	-1.4	0.9	1.1	-1.1	0.6	1.1	-0.8	-0.1	0.2
Bone: post-yield work	0.4	0.7	6.4	2.5	0.6	-0.3	0.1	0.0	-0.2	0.2	0.0	0.1	0.6	0.9
Progressive ratio test 1 active lever presses	2.4	4.2	10.5	-3.2	-2.4	2.1	-2.1	-2.1	2.0	-1.9	-2.0	1.7	1.3	0.9
Progressive ratio test 1 breakpoint	2.6	4.5	10.0	-3.2	-2.5	2.2	-2.1	-2.2	2.1	-2.0	-2.1	1.8	1.5	1.0
Progressive ratio test 1 inactive lever presses	0.1	0.2	1.8	-1.4	-0.4	0.3	-0.3	-0.3	0.2	-0.0	-0.4	0.2	0.0	-0.1
Progressive ratio test 2 active lever presses	0.7	1.0	3.3	-1.8	-1.0	0.9	-1.1	-1.0	0.9	-1.0	-0.9	0.7	0.6	0.3
Progressive ratio test 2 breakpoint	0.5	0.7	3.0	-1.7	-0.8	0.7	-0.9	-0.7	0.6	-0.8	-0.7	0.5	0.4	0.1
Progressive ratio test 2 inactive lever presses	0.6	1.9	2.3	-1.5	-1.4	1.4	-1.4	-1.5	1.4	-1.5	-1.5	1.3	1.2	1.1
Incentive Sensitization - Responses	0.1	0.4	0.7	0.4	0.9	-0.7	0.7	0.7	-0.7	0.3	0.8	-0.7	-0.5	-0.4
Incentive Sensitization - Breakpoint	0.2	0.5	0.9	0.3	0.9	-0.8	0.7	0.9	-0.7	0.3	0.9	-0.8	-0.6	-0.5
Sum of active levers in priming session hrs 5-6	0.1	0.1	0.2	-0.2	0.2	-0.3	0.3	0.2	-0.3	0.5	0.3	-0.3	-0.4	-0.4
Progressive ratio	0.1	0.4	3.0	-1.7	-0.7	0.5	-0.3	-0.4	0.4	-0.4	-0.4	0.2	-0.0	-0.2
Food seeking constrained by brief footshock	0.9	1.1	5.1	-2.3	-1.1	0.9	-0.8	-0.9	0.9	-0.9	-0.9	0.7	0.3	0.1
Seeking ratio, punishment vs. effort	0.0	0.0	0.1	0.3	0.1	-0.0	0.0	0.1	0.0	-0.0	0.0	0.0	0.1	0.2
Retroperitoneal fat weight	2.2	9.8	12.8	-1.5	-3.5	3.4	-2.2	-3.6	3.4	-2.6	-3.6	3.5	3.2	3.1
Reaction time number correct	0.3	1.2	2.2	1.5	-0.4	0.7	-1.2	-0.8	1.0	-1.4	-0.7	1.0	1.2	1.5
Reaction time mean minus median	0.2	1.2	5.2	-2.3	-1.1	0.9	-1.0	-0.6	0.9	-1.7	-0.6	0.5	0.2	-0.0
Reaction time mean minus median AUC	0.1	0.5	2.7	-1.7	-0.6	0.4	-0.4	-0.2	0.5	-1.2	-0.1	0.1	-0.2	-0.3
Reaction time num false alarms	0.2	0.3	2.5	-1.6	-0.3	0.1	0.0	0.1	-0.1	-0.0	0.1	-0.1	-0.4	-0.6
Reaction time num false alarms AUC	0.2	0.5	2.8	-1.7	-0.1	-0.2	0.4	0.4	-0.4	0.4	0.3	-0.4	-0.7	-1.0
Reaction time trials correct on left	0.3	1.2	2.2	1.5	-0.4	0.7	-1.2	-0.8	1.0	-1.4	-0.7	1.0	1.2	1.5
Reaction time trials on left	0.4	1.2	2.2	1.3	-0.5	0.7	-1.2	-0.9	1.0	-1.4	-0.8	1.0	1.2	1.5
Reaction time mean	0.2	0.5	1.1	-0.9	-0.7	0.6	-0.9	-0.6	0.7	-1.0	-0.7	0.5	0.4	0.3
Reaction time mean AUC	0.1	0.4	0.9	-0.6	-0.6	0.5	-0.8	-0.5	0.6	-0.9	-0.6	0.5	0.4	0.3
Median of all reaction times	0.2	0.3	0.6	-0.2	-0.5	0.5	-0.8	-0.6	0.5	-0.6	-0.7	0.5	0.5	0.5
Reaction time omissions	1.2	2.0	10.3	-3.2	-1.4	1.2	-1.4	-0.9	1.1	-1.7	-0.9	0.7	0.2	-0.2
Reaction time false alarm rate	1.1	1.5	3.5	-1.9	0.5	-0.8	1.1	1.0	-1.1	1.3	0.9	-1.1	-1.5	-1.8
Reaction time premature initiation rate	1.1	1.7	3.3	-1.8	-1.6	1.5	-1.3	-1.2	1.4	-1.3	-1.1	1.2	0.9	0.8
Reaction time premature initiations	0.9	2.8	4.1	-0.9	-1.8	1.8	-1.9	-1.6	1.9	-2.0	-1.5	1.7	1.5	1.5
Std. dev. reaction times	0.3	0.9	5.2	-2.3	-0.9	0.7	-0.7	-0.4	0.7	-1.4	-0.5	0.3	-0.0	-0.3
Reaction time trials completed	0.4	1.2	2.2	1.3	-0.5	0.7	-1.2	-0.9	1.0	-1.4	-0.8	1.0	1.2	1.5
Reaction time trials AUC	0.3	1.0	2.9	1.7	-0.2	0.5	-1.0	-0.7	0.8	-1.2	-0.6	0.8	1.1	1.4
Run reversals in cocaine runway, females	0.3	0.3	0.6	0.8	-0.3	0.4	-0.5	-0.4	0.5	-0.6	-0.6	0.5	0.7	0.7
Run reversals in cocaine runway, males	1.2	1.3	2.1	-0.6	1.0	-1.1	0.9	1.2	-1.0	0.8	1.3	-1.3	-1.4	-1.4
Latency to leave start box in cocaine runway	0.6	0.8	1.6	-0.0	0.7	-0.8	1.0	0.8	-1.0	1.3	0.8	-0.9	-1.0	-1.1
Latency to leave start box in cocaine runway, F	0.6	0.7	1.5	-1.1	0.4	-0.6	0.6	0.6	-0.7	1.0	0.7	-0.8	-1.1	-1.2
Latency to leave start box in cocaine runway, M	0.7	0.7	2.5	1.6	0.9	-0.8	0.8	0.7	-0.8	0.8	0.6	-0.6	-0.5	-0.3
Std. dev. time between licks in bursts	0.3	0.7	2.9	-1.7	-1.0	0.9	-0.7	-0.6	0.7	-0.4	-0.4	0.7	0.5	0.3
Total sessions with >9 infusions	0.8	1.0	4.2	-2.0	-1.1	0.9	-1.1	-1.0	0.8	-0.7	-0.8	0.7	0.4	0.1
Short access day 1 total inactive lever presses	0.4	0.9	3.3	-1.8	-1.0	0.9	-1.0	-0.8	0.9	-0.7	-0.8	0.7	0.5	0.3
Short access day 10 total inactive lever presses	0.0	0.0	0.1	0.1	0.3	-0.2	-0.1	0.2	-0.2	0.3	0.1	-0.2	-0.2	-0.1
Short access day 1 total infusions	1.2	2.4	4.0	-1.6	-1.6	1.6	-2.0	-1.6	1.5	-1.8	-1.5	1.4	1.3	1.1
Short access day 10 total infusions	0.5	0.9	3.3	-1.8	-0.9	0.8	-1.3	-0.9	0.7	-0.9	-1.0	0.5	0.3	0.0
Short access total infusions	2.6	3.7	6.0	-2.4	-2.1	1.9	-2.4	-2.0	1.9	-2.0	-1.9	1.6	1.4	1.1
Short access day 1 locomotion	0.2	0.4	1.3	-1.1	-0.6	0.5	-0.8	-0.6	0.5	-0.8	-0.5	0.4	0.4	0.2
Short access day 10 total locomotion	0.2	0.7	1.4	-1.0	-0.8	0.7	-1.2	-0.7	0.8	-1.1	-0.8	0.6	0.6	0.4
Short access total locomotion	0.7	1.1	2.0	-1.4	-1.2	1.1	-1.4	-1.1	1.0	-1.0	-0.9	0.9	0.8	0.6
One hour access (0.3 mA shock)	0.1	0.1	0.3	0.6	0.2	-0.1	-0.3	-0.2	-0.0	-0.4	-0.2	0.0	0.2	0.2
Compulsive drug intake	0.4	0.7	1.3	0.5	0.9	-0.9	1.1	0.8	-0.9	0.9	0.7	-0.8	-0.7	-0.6
One hour access (shock baseline)	0.1	0.2	0.5	0.5	-0.1	0.2	-0.7	-0.4	0.3	-0.6	-0.2	0.3	0.4	0.5
Social response proportion	1.3	1.6	2.6	-0.1	-1.2	1.3	-1.1	-1.4	1.3	-1.4	-1.6	1.4	1.4	1.4
Social responses	0.4	0.5	3.8	-2.0	-0.6	0.4	-0.4	-0.5	0.3	-0.5	-0.6	0.1	-0.3	-0.5
Social time	0.7	1.1	1.7	0.5	-0.8	1.0	-1.2	-1.0	1.0	-1.0	-1.3	1.1	1.2	1.3
Soleus weight	0.1	0.3	2.2	1.5	0.3	-0.2	0.1	0.2	-0.1	0.3	0.2	0.1	0.4	0.6
Bone: stiffness	2.5	4.6	24.9	5.0	2.4	-2.0	1.8	1.6	-1.8	1.4	1.7	-1.2	-0.4	0.2
Tibialis anterior weight	7.9	27.2	34.0	4.0	5.8	-5.8	5.1	5.5	-5.5	5.2	5.3	-5.4	-5.0	-4.6
Time to tail flick, vehicle, before self-admin	0.2	0.3	1.8	-1.3	-0.4	0.4	-0.5	-0.4	0.2	-0.4	-0.4	0.1	-0.0	-0.2
Time to tail flick, vehicle, after self-admin	0.2	0.5	0.8	0.6	0.9	-0.8	0.7	0.5	-0.8	0.5	0.4	-0.8	-0.7	-0.7
Time to tail flick, test, before self-admin	0.3	0.3	0.6	-0.3	0.4	-0.5	0.4	0.8	-0.5	0.3	0.7	-0.7	-0.8	-0.8
Time to tail flick, test, after self-admin	0.2	0.2	0.3	0.5	0.6	-0.5	0.5	0.4	-0.5	0.3	0.4	-0.4	-0.2	-0.2
Delta time to tail flick, vehicle, before/after SA	0.1	0.1	0.9	0.9	0.2	-0.1	0.1	-0.2	0.0	-0.2	-0.2	0.1	0.2	0.3
Delta time to tail flick, test, before/after SA	0.0	0.0	0.1	0.3	0.1	0.0	0.1	-0.3	-0.0	-0.0	-0.3	0.1	0.2	0.3
Tibia length	0.8	2.1	10.2	3.2	-0.1	0.5	-0.7	-1.0	0.7	-0.3	-1.0	1.2	1.8	2.2
Ambulatory time before self-admin	0.2	0.7	2.2	-1.5	-1.1	0.9	-1.0	-0.7	0.8	-0.6	-0.5	0.7	0.4	0.2
Ambulatory time after self-admin	2.9	4.6	5.8	-1.0	-2.4	2.3	-2.2	-2.2	2.3	-2.3	-2.2	2.3	2.1	2.0
Bone: tissue strength	0.5	0.6	1.9	1.4	0.8	-0.7	1.0	0.5	-0.7	0.9	0.6	-0.5	-0.3	-0.2
Total heroin consumption	0.4	0.5	1.4	1.2	-0.4	0.5	-0.4	-0.5	0.6	-0.0	-0.4	0.7	0.9	1.0
Bone: trabecular number	0.5	0.9	5.7	2.4	0.1	0.2	-0.2	-0.2	0.4	-0.6	-0.1	0.6	1.0	1.3
Bone: trabecular spacing	0.3	0.4	1.0	-1.0	0.3	-0.4	0.6	0.4	-0.5	0.9	0.4	-0.6	-0.8	-1.0
Bone: trabecular thickness	0.7	1.0	1.5	0.9	1.1	-1.1	1.0	1.2	-1.0	0.3	1.2	-1.0	-0.9	-0.8
Bone: trabecular tissue density	2.9	5.1	6.7	0.3	2.2	-2.3	2.4	2.2	-2.6	2.5	2.2	-2.4	-2.4	-2.5
Water consumed over 24 hours	0.8	1.6	2.7	0.2	-1.2	1.3	-1.0	-1.2	1.4	-1.1	-1.1	1.5	1.6	1.7
Number of responses in last shaping day	0.1	0.2	0.3	-0.2	0.4	-0.5	0.4	0.3	-0.5	0.3	0.3	-0.5	-0.5	-0.6