Hub : Genes

Mindy2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	OFC	gene expression	Mindy2	0.26	0.19	6.8e-04	0.08	0.08	0.09	0.07	7.2e-03	6.9e-03	4.8e-03	7.8e-03
2	PL	gene expression	Mindy2	0.05	0.04	3.6e-06	0.04	0.04	0.04	0.04	3.7e-05	1.4e-05	5.7e-05	3.4e-05
3	Adipose	gene expression	Mindy2	0.07	0.06	1.2e-08	0.06	0.06	0.06	0.06	6.4e-07	4.9e-07	5.0e-07	6.5e-07
4	Liver	gene expression	Mindy2	0.43	0.25	1.4e-08	0.05	0.05	0.06	0.05	1.4e-06	1.7e-06	6.8e-07	1.2e-06

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bone: apparent density	0.3	0.6	0.8	0.8	-0.9	-0.9	-0.2
Area under the delay curve	0.2	0.2	0.7	-0.4	-0.1	-0.1	0.8
BMI with tail	4.7	15.1	19.0	-4.4	4.0	4.1	2.9
BMI without tail	2.1	4.3	5.5	-2.1	2.3	2.4	1.2
Body weight	3.6	15.1	18.9	-4.1	4.3	4.3	2.5
Weight adjusted by age	6.2	7.0	11.0	-3.3	2.8	2.7	1.4
Bone surface	0.1	0.1	0.1	-0.4	0.4	0.3	0.2
Bone volume	0.0	0.0	0.0	0.1	0.1	0.0	0.1
Breakpoint value in progressive ratio session	0.3	0.3	0.4	0.0	0.6	0.7	-0.6
Number of licking bursts	1.5	1.8	2.3	1.3	-1.5	-1.5	-1.0
Context. condit. distance diff. score	0.7	0.9	1.3	0.9	-1.2	-1.1	-0.3
Locomotion velocity, session 1	2.4	2.6	6.3	-0.7	1.4	1.3	-2.5
Locomotion distance, session 1	0.7	0.9	2.7	0.5	-0.5	-0.5	-1.6
Locomotion velocity, session 2	0.4	0.4	0.8	-0.9	0.5	0.5	-0.6
Locomotion distance, session 2	0.6	0.8	2.5	-0.4	0.5	0.4	-1.6
Locomotion velocity, session 3	0.2	0.3	0.6	0.7	-0.1	-0.1	-0.8
Locomotion distance, session 3	2.2	2.4	3.8	2.0	-1.5	-1.4	-1.3
Stereotopy head waving bouts, day 3	1.3	1.6	3.0	-1.3	0.8	0.8	1.7
Stereotopy head waving duration, day 3	1.4	1.7	2.7	-1.5	0.9	0.9	1.7
Locomotion velocity, session 7	4.9	5.4	12.9	2.2	-1.4	-1.4	-3.6
Locomotion distance, session 7	4.3	5.4	14.2	1.9	-1.4	-1.4	-3.8
Stereotopy head waving bouts, day 7	2.5	2.8	6.9	-1.4	1.1	1.1	2.6
Stereotopy head waving duration, day 7	2.6	3.2	7.6	-1.7	1.0	1.1	2.8
Locomotion velocity, session 8	1.3	1.6	5.4	0.1	0.6	0.6	-2.3
Locomotion distance, session 8	0.9	1.3	3.0	0.7	-0.9	-0.9	-1.7
Degree of sensitization distance	0.4	0.4	1.2	0.2	-0.4	-0.4	-1.1
Degree of sensitization stereotypy	1.4	1.5	3.2	-1.2	0.8	0.8	1.8
Conditioned locomotion	0.0	0.1	0.1	0.2	-0.3	-0.3	0.1
Cocaine response after cond. corrected	2.5	2.8	3.8	-1.9	2.0	2.0	0.0
Cocaine response after cond. not corrected	1.5	1.6	2.0	-1.4	1.4	1.4	-0.7
Cocaine response before conditioning	1.0	1.2	1.5	1.2	-1.2	-1.2	-0.7
Saline control response	0.4	0.5	1.8	-0.0	-0.4	-0.4	1.3
Bone: connectivity density	0.7	1.1	1.5	1.2	-1.2	-1.2	-0.1
Bone: cortical apparent density	0.5	0.6	1.0	1.0	-0.8	-0.8	-0.4
Bone: cortical area	0.1	0.1	0.2	0.4	-0.0	-0.0	0.4
Bone: cortical porosity	0.7	0.8	1.8	1.3	-0.9	-0.8	-0.1
Bone: cortical porosity	1.5	1.6	2.5	1.6	-1.3	-1.3	-0.8
Bone: cortical thickness	1.0	1.7	2.8	1.7	-1.4	-1.4	-0.4
Bone: cortical thickness	0.6	0.7	1.0	1.0	-0.8	-0.9	-0.3
Bone: cortical tissue density	0.5	0.6	1.0	1.0	-0.8	-0.8	-0.4
Condit. Reinf. active minus inactive responses	0.0	0.0	0.1	0.3	-0.1	-0.1	-0.1
Condit. Reinf. active-inactive response ratio	0.4	0.4	0.6	0.6	-0.8	-0.8	-0.0
Condit. Reinf. active responses	0.2	0.3	0.5	-0.3	0.7	0.7	0.1
Condit. Reinf. inactive responses	0.9	1.0	1.5	-1.0	1.2	1.2	0.1
Incentive salience index mean	0.0	0.0	0.0	0.2	0.0	0.0	-0.2
Condit. Reinf. lever presses	0.0	0.1	0.2	0.2	-0.1	-0.1	-0.4
Condit. Reinf. active minus inactive responses	2.5	3.1	4.0	-2.0	1.9	1.9	1.2
Condit. Reinf. active-inactive response ratio	1.8	1.9	3.0	-1.7	1.0	1.0	1.6
Condit. Reinf. active responses	1.0	1.4	2.0	-1.2	1.4	1.4	0.5
Condit. Reinf. inactive responses	0.6	0.8	2.1	1.0	-0.0	-0.1	-1.5
Condit. Reinf. lever presses	0.4	0.6	0.8	0.9	-0.8	-0.9	0.0
Condit. Reinf. lever reinforcers received	0.6	0.8	1.1	-0.9	1.0	1.0	0.6
Conditioned reinforcement - actives	0.7	0.7	2.3	-0.7	-0.1	-0.0	1.5
Conditioned reinforcement - inactives	0.0	0.0	0.1	0.1	-0.1	-0.1	0.4
Conditioned locomotion	0.4	0.5	0.9	-0.1	-0.7	-0.7	0.9
Patch foraging indifference point 0 sec	0.2	0.3	0.5	-0.3	0.7	0.7	-0.1
Patch foraging indifference point AUC	0.4	0.5	1.7	0.4	0.2	0.2	-1.3
Delay disc. indifference point, 0s delay	0.3	0.3	0.7	-0.3	-0.5	-0.5	0.8
Delay disc. indifference point, 16s delay	0.4	0.4	1.0	0.2	-0.5	-0.5	1.0
Delay disc. indifference point, 2s delay	0.3	0.4	1.3	-0.2	-0.3	-0.3	1.1
Delay disc. indifference point, 24s delay	0.2	0.2	0.3	0.4	-0.5	-0.5	0.3
Delay disc. indifference point, 4s delay	0.2	0.3	0.7	-0.1	-0.4	-0.4	0.9
Delay disc. indifference point, 8s delay	0.0	0.0	0.1	-0.3	0.2	0.2	0.1
Indifference point function ln k	0.4	0.6	1.2	-1.1	0.7	0.6	0.7
Indifference point function log k	0.4	0.6	1.2	-1.1	0.7	0.6	0.7
Patch foraging total patch changes 0 sec	0.2	0.4	0.7	-0.4	0.8	0.8	-0.1
Patch foraging total patch changes 12 sec	0.1	0.2	0.5	0.7	-0.0	-0.0	-0.5
Patch foraging total patch changes 18 sec	0.1	0.1	0.2	-0.4	0.4	0.5	0.0
Patch foraging total patch changes 24 sec	0.3	0.4	1.3	-0.1	0.5	0.4	-1.1
Patch foraging total patch changes 6 sec	0.5	0.7	1.3	-0.3	0.8	0.8	-1.2
Patch foraging time to switch 0 sec	1.3	2.0	3.4	1.8	-1.5	-1.5	-0.2
Patch foraging water rate 0 sec	2.1	3.4	4.5	-2.1	2.1	2.0	0.7
Patch foraging water rate 12 sec	3.6	5.5	8.2	-2.9	2.6	2.6	0.3
Patch foraging water rate 18 sec	0.7	0.9	2.1	-1.5	0.9	0.8	0.1
Patch foraging water rate 24 sec	0.4	0.6	1.3	0.0	0.7	0.7	-1.2
Patch foraging water rate 6 sec	1.6	2.3	4.4	-2.1	1.4	1.4	1.0
Seeking ratio, delayed vs. immediate footshock	0.4	0.5	0.8	-0.6	0.9	0.9	-0.0
Distance traveled before self-admin	1.1	1.1	4.4	0.3	-0.2	-0.1	2.1
Distance traveled after self-admin	0.9	1.0	1.4	-0.6	1.2	1.2	1.1
Extensor digitorum longus weight	6.0	23.7	31.9	-5.1	5.6	5.6	2.3
Bone: elastic displacement	0.4	0.4	0.6	-0.7	0.6	0.6	0.5
Bone: elastic work	0.0	0.1	0.1	0.3	0.2	0.2	0.2
Bone: endosteal estimation	2.0	4.3	5.6	-2.4	2.2	2.2	1.4
Bone: endosteal perimeter	3.0	6.2	7.8	-2.8	2.7	2.7	1.6
Epididymis fat weight	0.1	0.3	0.9	-0.6	0.2	0.2	1.0
Delta time in closed arm before/after self-admin	0.1	0.1	0.2	0.2	-0.3	-0.3	0.4
Delta time in open arm before/after self-admin	1.1	1.0	1.5	1.1	-0.9	-0.8	-1.2
Diff in mean of infusions in LGA sessions	1.1	1.2	2.3	-1.5	0.9	1.0	0.9
Delay discount exponential model param	0.2	0.2	0.7	0.3	-0.0	-0.0	-0.8
Extinction: sum of active levers before priming	0.0	0.0	0.0	-0.2	-0.1	-0.1	-0.2
Active lever presses in extinction session 6	0.1	0.1	0.1	0.0	-0.3	-0.3	0.4
Bone: final force	0.3	0.5	0.9	-0.2	0.9	0.9	-0.4
Bone: final moment	0.1	0.2	0.4	0.2	0.5	0.5	-0.6
Food consumed during 24 hour testing period	2.2	2.7	7.3	-1.4	0.9	0.9	2.7
Glucose	0.4	0.6	1.0	-0.7	1.0	1.0	0.4
Heart weight	0.2	0.3	0.5	-0.1	0.7	0.7	0.6
Delay discount hyperbolic model param	0.2	0.2	0.8	0.2	0.1	0.1	-0.9
Intermittent access intake day 1-15 change	1.0	1.0	1.3	1.1	-1.1	-1.1	-0.5
Intermittent access intake escalation	1.2	1.2	1.7	1.1	-1.3	-1.3	-0.3
Intermittent access intake escalation 2	0.1	0.1	0.1	0.1	-0.3	-0.2	0.3
Intermitt. access day 1 inactive lever presses	1.2	1.3	1.8	1.1	-1.3	-1.3	-0.5
Intermitt. access day 15 inactive lever presses	0.7	0.8	2.1	0.5	-0.6	-0.5	1.5
Intermitt. access escalation Index	0.8	0.7	1.0	-0.8	1.0	1.0	0.2
Intermittent access day 1 total infusions	0.3	0.4	0.6	0.6	-0.8	-0.7	0.3
Intermittent access day 15 total infusions	1.4	1.6	2.3	1.4	-1.5	-1.4	0.3
Intermittent access terminal intake (last 3 days)	0.8	0.9	1.6	1.3	-1.0	-0.9	0.4
Intermittent access total infusions	0.4	0.4	0.5	0.7	-0.7	-0.7	0.4
Intermittent access day 1 locomotion	1.4	1.5	2.6	0.8	-1.6	-1.6	0.3
Intermittent access day 15 total locomotion	1.1	1.1	2.2	0.2	-1.5	-1.5	0.5
Intermittent access total locomotion	0.7	0.8	2.0	-1.0	-0.3	-0.3	1.4
Intermittent access standard deviation	1.4	1.5	2.1	1.5	-1.4	-1.4	-0.1
Left kidney weight	1.9	5.4	6.5	-2.4	2.5	2.6	1.7
Right kidney weight	1.8	5.1	7.5	-2.2	2.7	2.7	1.1
Cocaine induced anxiety	0.1	0.1	0.4	0.6	-0.3	-0.3	0.1
Post-drug Anxiety	1.9	2.1	3.0	1.7	-1.3	-1.4	-1.3
Baseline Anxiety	0.6	0.7	1.6	0.6	-0.6	-0.6	-1.2
Tail length	0.1	0.3	0.5	-0.4	0.7	0.7	0.5
Length with tail	0.7	2.7	4.0	-1.4	2.0	2.0	0.9
Length without tail	2.0	4.4	5.5	-2.3	2.1	2.1	1.8
Times rat made contact with spout	0.6	0.6	1.8	0.2	-0.6	-0.6	1.3
Lifetime Intake	0.5	0.5	0.9	1.0	-0.8	-0.7	-0.1
Liver weight, left	0.8	1.2	1.8	-1.4	1.2	1.2	0.4
Liver weight, right	1.4	2.4	3.7	-1.5	1.9	1.9	-0.0
Locomotor activity	5.4	8.5	11.4	-3.4	3.1	3.1	1.7
Locomotor testing distance	3.4	5.7	9.9	-3.1	2.3	2.3	1.5
Locomotor testing rearing	1.7	2.6	4.1	-2.0	1.7	1.7	0.7
Locomotion in novel chamber	0.6	0.8	1.1	0.1	-1.0	-1.0	0.9
Locomotion in novel chamber post-restriction	0.4	0.5	0.9	1.0	-0.7	-0.7	-0.4
Fecal boli incidents, locomotor time 1	0.3	0.3	1.0	0.5	-0.2	-0.2	1.0
Change in fecal boli incidents, locomotor task	0.4	0.3	0.9	-0.4	0.4	0.4	-0.9
Time >=10cm from walls, locomotor time 1	0.8	0.8	2.1	-1.4	0.5	0.4	0.9
Bouts of movement, locomotor time 1	0.2	0.2	0.3	-0.5	0.4	0.4	0.5
Total resting periods, locomotor time 1	0.3	0.3	0.5	-0.7	0.4	0.4	0.6
Rest time, locomotor task time 1	0.2	0.2	0.6	-0.8	0.1	0.0	-0.1
Distance moved, locomotor task time 1	0.1	0.1	0.2	0.4	-0.3	-0.3	0.1
Vertical activity count, locomotor time 1	0.3	0.3	0.4	0.6	-0.5	-0.4	0.7
Time >=10cm from walls, locomotor time 2	0.1	0.2	0.5	-0.7	0.2	0.1	0.2
Bouts of movement, locomotor time 2	2.1	2.2	3.5	-1.9	1.4	1.4	1.3
Total resting periods, locomotor time 2	2.3	2.5	4.1	-2.0	1.5	1.4	1.3
Rest time, locomotor task time 2	0.1	0.1	0.2	0.3	-0.4	-0.4	-0.0
Distance moved, locomotor task time 2	0.0	0.0	0.1	0.1	-0.0	-0.1	-0.3
Vertical activity count, locomotor time 2	0.4	0.5	0.6	0.7	-0.8	-0.8	0.4
Light reinforcement 1	2.2	4.0	5.6	-2.0	2.4	2.3	1.0
Light reinforcement 2	0.3	0.4	0.8	0.9	-0.4	-0.5	-0.5
Bone: marrow area	2.0	4.4	5.8	-2.4	2.2	2.2	1.4
Bone: maximum diameter	1.8	3.3	4.1	-2.0	2.0	2.0	1.0
Bone: maximum force	0.4	0.7	1.1	-0.7	1.0	1.0	0.4
Bone: maximum moment	0.1	0.2	0.4	-0.2	0.6	0.6	0.2
Mean time between licks in bursts	0.2	0.3	0.4	0.5	-0.6	-0.6	-0.3
Mean num. licks in bursts	1.1	1.3	2.4	-1.0	1.0	1.0	1.5
Cd content in liver	0.3	0.3	0.8	-0.4	-0.3	-0.3	0.9
Co content in liver	0.0	0.0	0.1	0.2	-0.1	-0.1	-0.4
Cu content in liver	0.2	0.2	0.4	0.0	0.6	0.6	-0.0
Fe content in liver	0.3	0.4	0.5	0.6	-0.7	-0.7	0.4
K content in liver	1.6	1.6	2.2	-1.3	1.5	1.5	0.5
Mg content in liver	2.5	2.6	3.9	-1.6	2.0	2.0	0.2
Mn content in liver	0.2	0.2	0.6	0.2	0.1	0.1	0.8
Na content in liver	2.0	2.1	3.1	-1.5	1.8	1.8	-0.3
Rb content in liver	1.6	1.9	3.4	-1.8	1.5	1.4	0.3
Se content in liver	0.2	0.3	0.4	0.4	-0.7	-0.7	0.2
Sr content in liver	0.0	0.0	0.1	0.3	-0.1	-0.1	-0.2
Zn content in liver	0.4	0.5	1.1	1.0	-0.6	-0.6	-0.1
Bone: minimum diameter	0.1	0.3	1.1	0.2	-0.1	-0.1	1.0
Time in familiar zone, hab. session 1	0.7	0.7	2.7	0.2	-0.0	-0.1	-1.6
Time in novel zone, hab. session 1	0.3	0.3	1.2	0.0	-0.3	-0.2	1.1
Total zone transitions, hab. session 1	0.8	1.1	1.8	1.3	-0.7	-0.7	-1.3
Total locomotion distance, hab. session 1	0.1	0.1	0.4	0.4	-0.1	-0.2	-0.6
Locomotion velocity, hab. session 1	0.0	0.0	0.0	-0.0	0.1	0.1	0.2
Time in familiar zone, hab. session 2	1.4	1.4	4.3	1.1	-0.1	-0.1	-2.1
Time in novel zone, hab. session 2	1.1	1.1	4.0	-0.6	-0.2	-0.2	2.0
Total zone transitions, hab. session 2	0.3	0.4	0.8	-0.2	0.6	0.6	-0.9
Total locomotion distance, hab. session 2	0.5	0.7	1.1	-0.8	1.0	1.0	0.3
Locomotion velocity, hab. session 2	0.3	0.4	0.6	-0.6	0.8	0.7	0.3
Novel to familiar place preference ratio	1.3	1.3	2.4	-1.5	1.0	1.0	1.0
Novelty place preference	1.2	1.3	2.3	-1.5	1.0	1.0	0.8
Time in novel zone, NPP test	1.3	1.4	2.3	-1.5	1.1	1.1	0.8
Total zone transitions, NPP test	0.2	0.2	0.4	-0.5	0.6	0.6	0.0
Total locomotion distance, NPP test	0.5	0.7	0.9	-0.7	1.0	1.0	0.5
Locomotion velocity, NPP test	0.2	0.3	0.4	-0.5	0.6	0.6	0.5
Intraocular pressure	0.0	0.0	0.0	-0.2	0.1	0.1	-0.0
Delta distance traveled before/after self-admin	1.2	1.3	1.8	-0.9	1.3	1.3	-1.0
Delta ambulatory time before/after self-admin	0.7	0.7	1.1	-0.6	0.9	0.8	-1.0
Parametrial fat weight	0.1	0.2	0.6	0.1	0.3	0.3	-0.8
Pavlov. Cond. lever latency	0.3	0.4	1.2	0.4	-0.4	-0.3	-1.1
Pavlov. Cond. magazine entry latency	0.8	1.0	1.6	1.3	-0.9	-0.9	-1.0
Pavlov. Cond. change in total contacts	1.4	1.5	5.6	-0.6	-0.0	-0.0	2.4
Pavlov. Cond. index score	0.4	0.5	0.9	1.0	-0.8	-0.8	0.2
Pavlov. Cond. latency score	0.2	0.2	0.5	0.7	-0.4	-0.4	0.3
Pavlov. Cond. lever contacts	0.1	0.1	0.3	0.3	-0.0	-0.0	0.5
Pavlov. Cond. magazine entry number	0.8	1.0	1.4	-1.2	1.1	1.1	0.1
Pavlov. Cond. intertrial magazine entries	0.4	0.5	1.7	0.2	0.4	0.4	-1.3
Pavlov. Cond. lever-magazine prob. diff.	0.3	0.4	0.8	0.9	-0.6	-0.6	0.1
Pavlov. Cond. response bias	0.3	0.4	0.6	0.8	-0.7	-0.7	0.3
Pavlov. Cond. lever latency	0.7	1.0	1.7	-1.3	0.8	0.8	1.0
Pavlov. Cond. magazine entry latency	2.7	3.1	4.8	2.2	-1.9	-1.9	-0.6
Pavlov. Cond. change in total contacts	0.3	0.4	0.5	0.7	-0.7	-0.7	-0.3
Pavlov. Cond. index score	0.9	1.2	1.8	1.3	-1.0	-1.0	-0.9
Pavlov. Cond. latency score	0.6	0.7	1.2	1.1	-0.8	-0.8	-0.6
Pavlov. Cond. lever contacts	0.2	0.3	0.6	0.8	-0.4	-0.5	-0.5
Pavlov. Cond. magazine entry number	2.8	3.4	5.0	-2.2	1.9	1.9	1.3
Pavlov. Cond. intertrial magazine entries	0.4	0.5	0.8	-0.6	0.9	0.9	-0.4
Pavlov. Cond. lever-magazine prob. diff.	1.2	1.5	2.2	1.5	-1.1	-1.1	-1.1
Pavlov. Cond. response bias	0.9	1.2	2.0	1.4	-1.1	-1.1	-0.6
Time in closed arm before self-admin	0.9	1.0	2.5	-1.6	-0.4	-0.4	1.1
Time in closed arm after self-admin	0.4	0.4	0.7	-0.8	-0.3	-0.3	0.8
Time in open arm before self-admin	0.8	0.8	1.7	1.3	0.9	0.9	-0.1
Time in open arm after self-admin	1.1	1.2	3.3	1.8	0.0	0.0	-1.3
Bone: periosteal estimation	1.2	2.4	2.8	-1.5	1.7	1.7	1.3
Bone: periosteal perimeter	1.7	2.9	3.5	-1.7	1.9	1.9	1.3
Bone: post-yield work	0.3	0.4	0.8	-0.7	0.4	0.4	0.9
Progressive ratio test 1 active lever presses	0.1	0.1	0.2	-0.4	0.2	0.3	0.3
Progressive ratio test 1 breakpoint	0.0	0.0	0.0	-0.1	-0.2	-0.1	0.2
Progressive ratio test 1 inactive lever presses	1.5	1.6	2.2	1.5	-1.1	-1.0	-1.5
Progressive ratio test 2 active lever presses	0.2	0.2	0.5	-0.7	0.3	0.3	0.5
Progressive ratio test 2 breakpoint	0.3	0.3	0.7	-0.9	0.5	0.5	0.3
Progressive ratio test 2 inactive lever presses	0.5	0.6	0.9	0.6	-1.0	-0.9	0.3
Incentive Sensitization - Responses	0.3	0.3	0.5	-0.7	0.5	0.5	0.5
Incentive Sensitization - Breakpoint	0.1	0.1	0.3	-0.5	0.3	0.3	0.3
Sum of active levers in priming session hrs 5-6	0.2	0.2	0.5	-0.7	0.2	0.2	0.3
Progressive ratio	0.9	1.1	1.2	1.0	-1.1	-1.1	1.0
Food seeking constrained by brief footshock	0.3	0.4	0.7	-0.4	0.9	0.8	-0.3
Seeking ratio, punishment vs. effort	3.0	3.6	5.4	-1.9	2.3	2.3	-0.6
Retroperitoneal fat weight	0.1	0.2	0.5	-0.7	0.5	0.5	0.1
Reaction time number correct	2.0	2.9	6.0	-2.5	1.6	1.6	0.5
Reaction time mean minus median	0.8	1.1	2.5	1.6	-0.4	-0.3	-1.3
Reaction time mean minus median AUC	1.6	2.0	3.7	1.9	-0.8	-0.8	-1.8
Reaction time num false alarms	0.9	1.2	1.8	1.4	-0.8	-0.9	-1.2
Reaction time num false alarms AUC	0.3	0.4	0.8	0.8	-0.4	-0.4	-0.9
Reaction time trials correct on left	2.0	2.9	6.0	-2.5	1.6	1.6	0.5
Reaction time trials on left	2.1	3.0	6.2	-2.5	1.7	1.6	0.5
Reaction time mean	3.0	4.2	6.7	2.6	-1.8	-1.8	-1.9
Reaction time mean AUC	2.6	3.5	5.8	2.4	-1.5	-1.5	-1.9
Median of all reaction times	3.6	4.9	6.8	2.6	-2.2	-2.2	-1.8
Reaction time omissions	0.2	0.2	0.4	-0.2	0.6	0.7	-0.1
Reaction time false alarm rate	1.7	2.4	4.8	2.2	-1.3	-1.3	-1.1
Reaction time premature initiation rate	1.2	1.6	2.5	-1.2	1.6	1.6	-0.3
Reaction time premature initiations	2.5	3.5	4.8	-2.2	2.1	2.1	-0.2
Std. dev. reaction times	1.6	2.2	4.7	2.2	-1.1	-1.0	-1.4
Reaction time trials completed	2.1	3.0	6.2	-2.5	1.7	1.6	0.5
Reaction time trials AUC	1.8	2.6	5.7	-2.4	1.5	1.5	0.5
Run reversals in cocaine runway, females	0.1	0.1	0.3	-0.5	0.1	0.1	0.6
Run reversals in cocaine runway, males	0.1	0.1	0.1	-0.3	0.2	0.2	-0.3
Latency to leave start box in cocaine runway	1.5	1.7	2.1	-1.4	1.4	1.4	0.8
Latency to leave start box in cocaine runway, F	0.2	0.3	0.4	-0.4	0.5	0.5	0.6
Latency to leave start box in cocaine runway, M	2.8	2.7	3.8	-1.9	1.7	1.8	1.0
Std. dev. time between licks in bursts	0.3	0.3	0.6	-0.6	0.8	0.7	-0.1
Total sessions with >9 infusions	0.3	0.3	0.6	0.8	-0.2	-0.1	-0.7
Short access day 1 total inactive lever presses	0.2	0.3	0.5	0.7	-0.3	-0.3	-0.6
Short access day 10 total inactive lever presses	0.6	0.6	1.2	0.1	-1.1	-1.1	0.4
Short access day 1 total infusions	0.6	0.7	1.7	1.3	-0.7	-0.6	-0.5
Short access day 10 total infusions	0.7	0.8	2.0	1.4	-0.6	-0.6	-0.6
Short access total infusions	1.2	1.3	2.7	1.6	-1.0	-0.9	-0.9
Short access day 1 locomotion	0.2	0.2	0.9	0.9	-0.2	-0.2	-0.1
Short access day 10 total locomotion	0.0	0.0	0.1	-0.2	0.1	0.1	0.2
Short access total locomotion	1.0	1.0	1.9	1.4	-1.0	-1.0	-0.4
One hour access (0.3 mA shock)	0.2	0.2	0.5	-0.5	0.2	0.2	0.7
Compulsive drug intake	0.4	0.4	0.7	-0.6	0.8	0.8	-0.2
One hour access (shock baseline)	0.4	0.5	0.7	0.5	-0.9	-0.8	0.5
Social response proportion	0.6	0.7	1.6	0.8	-0.5	-0.5	1.3
Social responses	0.1	0.1	0.3	0.3	0.2	0.3	0.5
Social time	0.4	0.6	2.2	0.3	0.0	0.0	1.5
Soleus weight	12.3	35.9	50.1	-6.4	7.1	7.1	1.8
Bone: stiffness	1.0	1.5	2.0	-1.2	1.4	1.4	1.0
Tibialis anterior weight	9.6	32.7	44.0	-6.0	6.6	6.6	2.7
Time to tail flick, vehicle, before self-admin	0.1	0.1	0.4	-0.6	-0.0	-0.1	-0.1
Time to tail flick, vehicle, after self-admin	0.7	0.7	1.8	-0.9	-0.5	-0.5	1.3
Time to tail flick, test, before self-admin	0.7	0.7	1.1	1.1	-0.9	-0.9	-0.1
Time to tail flick, test, after self-admin	2.5	2.6	5.3	2.3	-1.6	-1.6	0.1
Delta time to tail flick, vehicle, before/after SA	0.3	0.3	0.6	0.3	-0.6	-0.6	0.8
Delta time to tail flick, test, before/after SA	0.1	0.1	0.3	0.5	-0.1	-0.1	0.3
Tibia length	0.5	1.4	5.1	-0.4	-0.5	-0.5	2.3
Ambulatory time before self-admin	0.5	0.5	0.8	0.9	-0.5	-0.4	0.9
Ambulatory time after self-admin	0.3	0.3	0.6	0.0	0.8	0.8	-0.3
Bone: tissue strength	1.7	1.6	2.7	1.6	-1.3	-1.3	-0.6
Total heroin consumption	1.1	1.3	2.2	-1.0	1.5	1.5	0.1
Bone: trabecular number	1.1	1.7	2.2	1.4	-1.4	-1.5	-0.8
Bone: trabecular spacing	0.0	0.0	0.0	-0.1	0.1	0.1	0.1
Bone: trabecular thickness	0.2	0.2	0.3	0.4	-0.5	-0.5	0.4
Bone: trabecular tissue density	4.3	6.0	8.2	-2.7	2.9	2.8	-0.4
Water consumed over 24 hours	0.6	0.7	1.4	0.5	-0.8	-0.7	1.2
Number of responses in last shaping day	0.1	0.1	0.1	0.2	-0.3	-0.3	0.3