Mindy2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	OFC	gene expression	Mindy2	0.22	0.18	1.6e-03	0.07	0.08	0.08	0.08	7.7e-03	6.7e-03	5.0e-03	5.8e-03
2	IC	gene expression	Mindy2	0.1	0.08	6.9e-04	0.05	0.06	0.06	0.06	3.1e-03	1.8e-03	1.8e-03	2.0e-03
3	PL	gene expression	Mindy2	0.06	0.05	7.7e-07	0.05	0.06	0.05	0.05	1.7e-06	4.0e-07	1.8e-06	1.5e-06
4	Adipose	gene expression	Mindy2	0.1	0.08	1.5e-12	0.09	0.1	0.09	0.09	1.6e-10	1.1e-10	1.7e-10	2.0e-10
5	Liver	gene expression	Mindy2	0.58	0.19	2.8e-09	0.05	0.06	0.05	0.05	1.3e-06	7.3e-07	2.1e-06	1.5e-06

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5
Bone: apparent density	0.4	0.7	1.1	1.0	0.9	-0.9	-0.9	-0.4
Area under the delay curve	0.1	0.1	0.6	-0.2	0.1	-0.0	-0.1	-0.8
BMI with tail	6.2	21.6	26.5	-5.1	-4.7	4.9	4.9	3.4
BMI without tail	1.4	7.3	8.8	-3.0	-2.7	2.9	2.9	1.9
Body weight	4.4	19.2	22.3	-4.7	-4.5	4.6	4.6	3.5
Weight adjusted by age	2.2	6.6	7.4	-2.5	-2.6	2.7	2.7	2.3
Bone surface	0.1	0.1	0.4	-0.1	-0.3	0.3	0.3	0.6
Bone volume	0.0	0.0	0.2	0.1	-0.1	-0.0	0.0	0.4
Breakpoint value in progressive ratio session	0.4	0.8	0.9	-0.9	-0.8	1.0	1.0	0.7
Number of licking bursts	0.7	2.0	2.7	1.6	1.5	-1.5	-1.5	-0.9
Context. condit. distance diff. score	1.0	1.2	1.4	1.0	1.0	-1.1	-1.1	-1.2
Locomotion velocity, session 1	2.0	2.3	5.8	-0.7	-1.6	1.1	1.3	2.4
Locomotion distance, session 1	0.3	0.4	0.8	0.9	0.3	-0.6	-0.5	0.6
Locomotion velocity, session 2	0.3	0.3	1.0	-0.2	-0.5	0.4	0.5	1.0
Locomotion distance, session 2	0.4	0.6	2.1	0.0	-0.6	0.4	0.4	1.4
Locomotion velocity, session 3	0.1	0.1	0.4	0.4	-0.1	-0.2	-0.1	0.6
Locomotion distance, session 3	1.6	1.9	2.7	1.6	1.3	-1.5	-1.5	-0.7
Stereotopy head waving bouts, day 3	0.6	0.7	1.3	-1.1	-0.8	0.9	0.9	0.0
Stereotopy head waving duration, day 3	0.7	0.9	1.6	-1.3	-0.8	1.0	1.0	0.1
Locomotion velocity, session 7	1.5	1.7	2.9	1.7	1.2	-1.5	-1.4	-0.3
Locomotion distance, session 7	1.5	1.9	3.1	1.8	1.4	-1.5	-1.5	-0.5
Stereotopy head waving bouts, day 7	1.1	1.3	2.6	-1.6	-1.0	1.2	1.2	-0.0
Stereotopy head waving duration, day 7	0.9	1.1	2.4	-1.6	-0.9	1.1	1.0	-0.4
Locomotion velocity, session 8	0.8	0.9	3.2	-0.0	-0.9	0.5	0.6	1.8
Locomotion distance, session 8	0.5	0.8	1.5	1.2	0.7	-1.0	-0.9	0.0
Degree of sensitization distance	0.2	0.2	0.3	0.4	0.5	-0.4	-0.4	-0.6
Degree of sensitization stereotypy	0.6	0.7	1.4	-1.2	-0.7	0.9	0.8	-0.1
Conditioned locomotion	0.1	0.1	0.2	0.2	0.3	-0.3	-0.3	-0.5
Cocaine response after cond. corrected	2.7	4.1	4.5	-2.0	-2.1	2.1	2.1	1.8
Cocaine response after cond. not corrected	1.8	2.6	3.0	-1.4	-1.7	1.6	1.6	1.7
Cocaine response before conditioning	0.9	1.1	1.7	1.3	1.0	-1.1	-1.1	-0.6
Saline control response	0.2	0.2	1.1	-0.2	0.2	-0.1	-0.2	-1.0
Bone: connectivity density	0.8	1.3	1.8	1.3	1.1	-1.2	-1.2	-0.7
Bone: cortical apparent density	1.0	1.5	1.6	1.2	1.3	-1.3	-1.3	-1.2
Bone: cortical area	0.1	0.1	0.2	0.4	0.1	-0.3	-0.3	0.2
Bone: cortical porosity	1.1	1.2	1.3	1.1	1.2	-1.1	-1.1	-0.9
Bone: cortical porosity	1.5	1.7	2.0	1.4	1.4	-1.3	-1.3	-1.0
Bone: cortical thickness	1.5	2.4	3.3	1.8	1.5	-1.7	-1.7	-0.9
Bone: cortical thickness	0.5	0.6	1.0	1.0	0.7	-0.9	-0.8	-0.3
Bone: cortical tissue density	0.9	1.4	1.5	1.2	1.2	-1.2	-1.2	-1.1
Condit. Reinf. active minus inactive responses	0.0	0.0	0.1	0.2	-0.0	-0.1	-0.1	0.3
Condit. Reinf. active-inactive response ratio	0.4	0.4	0.5	0.7	0.6	-0.7	-0.7	-0.6
Condit. Reinf. active responses	0.4	0.5	0.7	-0.6	-0.8	0.6	0.6	0.8
Condit. Reinf. inactive responses	1.0	1.3	1.6	-1.1	-1.2	1.1	1.1	1.1
Incentive salience index mean	0.1	0.1	0.5	0.2	-0.2	-0.0	0.0	0.7
Condit. Reinf. lever presses	0.1	0.2	0.6	0.4	-0.1	-0.2	-0.1	0.8
Condit. Reinf. active minus inactive responses	2.7	4.1	4.5	-1.9	-2.1	2.0	2.1	2.1
Condit. Reinf. active-inactive response ratio	0.6	1.0	1.4	-1.2	-1.0	1.1	1.1	0.7
Condit. Reinf. active responses	1.9	2.8	4.3	-1.2	-1.8	1.5	1.6	2.1
Condit. Reinf. inactive responses	0.3	0.5	2.1	0.5	-0.5	0.0	0.2	1.4
Condit. Reinf. lever presses	0.5	0.7	1.4	1.2	0.6	-0.9	-0.8	0.1
Condit. Reinf. lever reinforcers received	1.3	1.9	3.1	-1.0	-1.5	1.2	1.3	1.8
Conditioned reinforcement - actives	0.1	0.5	1.3	-0.9	-0.1	0.4	0.3	-1.1
Conditioned reinforcement - inactives	0.1	0.2	0.7	0.2	0.3	-0.3	-0.4	-0.8
Conditioned locomotion	0.5	0.7	2.6	0.0	0.6	-0.4	-0.5	-1.6
Patch foraging indifference point 0 sec	0.3	0.9	2.0	-0.5	-1.2	0.7	0.8	1.4
Patch foraging indifference point AUC	0.1	0.3	1.3	0.1	-0.3	0.2	0.2	1.2
Delay disc. indifference point, 0s delay	0.4	0.5	1.3	0.3	0.5	-0.6	-0.6	-1.1
Delay disc. indifference point, 16s delay	0.4	0.6	2.1	-0.0	0.6	-0.4	-0.5	-1.5
Delay disc. indifference point, 2s delay	0.2	0.3	1.1	-0.1	0.3	-0.1	-0.2	-1.1
Delay disc. indifference point, 24s delay	0.2	0.4	0.9	0.3	0.5	-0.5	-0.5	-1.0
Delay disc. indifference point, 4s delay	0.3	0.3	1.1	0.2	0.4	-0.3	-0.4	-1.1
Delay disc. indifference point, 8s delay	0.0	0.0	0.1	-0.3	-0.1	0.3	0.2	-0.2
Indifference point function ln k	0.1	0.4	0.6	-0.8	-0.6	0.7	0.7	0.2
Indifference point function log k	0.1	0.4	0.6	-0.8	-0.6	0.7	0.7	0.2
Patch foraging total patch changes 0 sec	0.4	1.1	2.4	-0.5	-1.2	0.8	0.9	1.6
Patch foraging total patch changes 12 sec	0.1	0.1	0.3	0.2	-0.4	-0.0	0.1	0.6
Patch foraging total patch changes 18 sec	0.1	0.3	0.5	-0.4	-0.6	0.4	0.5	0.7
Patch foraging total patch changes 24 sec	0.3	1.0	3.9	0.1	-0.9	0.4	0.5	2.0
Patch foraging total patch changes 6 sec	0.7	1.2	3.0	-0.4	-1.1	0.8	0.9	1.7
Patch foraging time to switch 0 sec	0.8	3.0	5.0	1.3	1.8	-1.6	-1.7	-2.2
Patch foraging water rate 0 sec	1.1	4.3	5.2	-1.8	-2.2	2.0	2.1	2.3
Patch foraging water rate 12 sec	1.9	7.6	11.1	-2.2	-2.7	2.6	2.7	3.3
Patch foraging water rate 18 sec	0.4	0.9	1.8	-0.6	-1.0	0.8	0.8	1.3
Patch foraging water rate 24 sec	0.6	0.9	2.1	-0.6	-0.9	0.7	0.8	1.4
Patch foraging water rate 6 sec	1.5	2.3	2.6	-1.4	-1.6	1.5	1.5	1.4
Seeking ratio, delayed vs. immediate footshock	0.5	0.7	0.9	-0.7	-0.9	0.8	0.9	1.0
Distance traveled before self-admin	0.4	0.9	3.6	-0.7	0.5	0.0	-0.1	-1.9
Distance traveled after self-admin	0.7	1.2	1.9	-1.4	-1.1	1.2	1.1	0.3
Extensor digitorum longus weight	7.8	31.1	34.5	-5.8	-5.7	5.9	5.8	4.4
Bone: elastic displacement	0.3	0.3	0.7	-0.8	-0.4	0.7	0.6	0.1
Bone: elastic work	0.0	0.0	0.1	-0.1	-0.1	0.1	0.1	0.2
Bone: endosteal estimation	1.9	4.8	5.4	-2.2	-2.3	2.2	2.2	2.0
Bone: endosteal perimeter	2.9	7.1	8.0	-2.6	-2.8	2.7	2.7	2.5
Epididymis fat weight	0.0	0.1	0.2	-0.3	0.1	0.1	0.0	-0.4
Delta time in closed arm before/after self-admin	1.0	1.0	1.7	1.3	0.9	-1.1	-1.0	-0.4
Delta time in open arm before/after self-admin	0.1	0.1	0.2	0.4	0.3	-0.4	-0.4	-0.0
Diff in mean of infusions in LGA sessions	0.6	1.1	1.4	-1.2	-1.1	1.1	1.1	0.8
Delay discount exponential model param	0.1	0.1	0.6	0.3	-0.0	-0.1	-0.0	0.8
Extinction: sum of active levers before priming	0.3	0.5	0.6	-0.5	-0.8	0.7	0.7	0.7
Active lever presses in extinction session 6	0.4	0.4	0.6	-0.8	-0.5	0.7	0.7	0.3
Bone: final force	0.4	0.7	2.0	-0.2	-0.9	0.5	0.6	1.4
Bone: final moment	0.2	0.3	1.2	0.2	-0.4	0.1	0.2	1.1
Food consumed during 24 hour testing period	0.5	0.9	1.8	-1.3	-0.9	1.0	1.0	0.1
Glucose	1.0	1.5	2.0	-1.0	-1.3	1.2	1.2	1.4
Heart weight	0.9	1.4	2.8	-1.7	-1.1	1.3	1.2	-0.2
Delay discount hyperbolic model param	0.1	0.2	0.9	0.2	-0.2	0.0	0.1	0.9
Intermittent access intake day 1-15 change	0.2	1.3	2.7	0.6	1.1	-1.0	-1.1	-1.6
Intermittent access intake escalation	0.1	0.7	1.4	0.5	0.7	-0.8	-0.9	-1.2
Intermittent access intake escalation 2	0.1	0.2	0.8	-0.4	0.1	0.0	-0.1	-0.9
Intermitt. access day 1 inactive lever presses	0.3	3.6	4.1	1.8	2.0	-2.0	-2.0	-1.6
Intermitt. access day 15 inactive lever presses	0.1	0.3	1.2	-0.6	-0.1	0.2	0.1	-1.1
Intermitt. access escalation Index	0.1	0.4	0.6	-0.7	-0.7	0.6	0.6	0.2
Intermittent access day 1 total infusions	0.3	1.0	1.1	1.0	1.0	-0.9	-1.0	-0.9
Intermittent access day 15 total infusions	0.8	2.0	2.4	1.3	1.3	-1.4	-1.4	-1.5
Intermittent access terminal intake (last 3 days)	0.6	1.0	1.8	0.7	1.0	-0.9	-0.9	-1.4
Intermittent access total infusions	0.4	0.4	0.6	0.6	0.7	-0.6	-0.6	-0.8
Intermittent access day 1 locomotion	1.7	3.1	3.4	1.6	1.8	-1.8	-1.8	-1.8
Intermittent access day 15 total locomotion	0.6	2.4	3.5	1.2	1.5	-1.5	-1.5	-1.9
Intermittent access total locomotion	0.1	0.2	0.7	-0.1	0.2	-0.1	-0.2	-0.9
Intermittent access standard deviation	0.1	0.5	0.7	0.5	0.8	-0.6	-0.7	-0.8
Left kidney weight	0.9	7.1	10.9	-3.3	-2.7	2.8	2.7	1.4
Right kidney weight	1.4	9.8	13.9	-3.7	-3.2	3.3	3.2	1.9
Cocaine induced anxiety	0.1	0.2	0.7	0.1	0.5	-0.3	-0.4	-0.9
Post-drug Anxiety	2.3	2.7	3.1	1.5	1.8	-1.6	-1.6	-1.6
Baseline Anxiety	0.5	0.8	1.4	1.2	0.9	-1.0	-0.9	-0.2
Tail length	0.0	0.0	0.0	0.0	0.0	0.0	0.0	-0.1
Length with tail	0.6	2.6	3.0	-1.5	-1.7	1.6	1.6	1.7
Length without tail	2.2	11.8	12.3	-3.4	-3.5	3.4	3.5	3.4
Times rat made contact with spout	0.8	0.9	2.7	0.3	0.9	-0.6	-0.7	-1.6
Lifetime Intake	0.2	0.2	0.3	0.5	0.5	-0.5	-0.5	-0.3
Liver weight, left	3.7	6.5	7.5	-2.3	-2.6	2.5	2.6	2.7
Liver weight, right	1.4	2.5	4.5	-1.1	-1.6	1.4	1.5	2.1
Locomotor activity	5.9	9.3	11.4	-3.4	-3.2	3.2	3.2	2.2
Locomotor testing distance	2.4	5.9	7.8	-2.8	-2.4	2.6	2.6	1.6
Locomotor testing rearing	0.9	3.2	3.6	-1.9	-1.9	1.9	1.9	1.3
Locomotion in novel chamber	0.2	0.2	0.4	0.5	0.3	-0.5	-0.5	-0.6
Locomotion in novel chamber post-restriction	0.3	1.0	1.6	0.7	1.0	-0.9	-1.0	-1.3
Fecal boli incidents, locomotor time 1	0.1	0.3	1.0	-0.1	0.4	-0.3	-0.3	-1.0
Change in fecal boli incidents, locomotor task	0.2	0.2	0.8	0.2	-0.1	0.2	0.3	0.9
Time >=10cm from walls, locomotor time 1	0.2	0.2	0.4	-0.6	-0.4	0.5	0.4	-0.1
Bouts of movement, locomotor time 1	0.1	0.1	0.2	-0.3	-0.4	0.3	0.3	0.2
Total resting periods, locomotor time 1	0.1	0.1	0.3	-0.3	-0.5	0.3	0.3	0.2
Rest time, locomotor task time 1	0.0	0.0	0.1	0.0	-0.2	0.0	0.1	0.4
Distance moved, locomotor task time 1	0.0	0.1	0.2	0.4	0.4	-0.3	-0.3	-0.3
Vertical activity count, locomotor time 1	0.0	0.3	0.9	0.3	0.5	-0.4	-0.5	-1.0
Time >=10cm from walls, locomotor time 2	0.0	0.1	0.4	0.1	-0.2	0.1	0.2	0.6
Bouts of movement, locomotor time 2	0.4	1.4	2.3	-1.5	-1.1	1.4	1.3	0.3
Total resting periods, locomotor time 2	0.4	1.6	2.5	-1.6	-1.2	1.5	1.4	0.4
Rest time, locomotor task time 2	0.1	0.2	0.2	0.4	0.4	-0.5	-0.5	-0.4
Distance moved, locomotor task time 2	0.0	0.0	0.1	0.3	0.0	-0.0	-0.0	0.2
Vertical activity count, locomotor time 2	0.3	0.8	2.0	0.5	0.8	-0.6	-0.7	-1.4
Light reinforcement 1	1.4	6.1	7.4	-2.3	-2.7	2.5	2.5	2.3
Light reinforcement 2	0.1	0.2	0.5	0.7	0.2	-0.4	-0.4	0.4
Bone: marrow area	1.9	4.7	5.4	-2.2	-2.3	2.2	2.2	1.9
Bone: maximum diameter	2.0	3.9	4.6	-1.8	-2.1	1.9	2.0	2.1
Bone: maximum force	0.3	0.5	1.1	-0.4	-0.8	0.6	0.6	1.0
Bone: maximum moment	0.1	0.1	0.5	0.0	-0.4	0.1	0.2	0.7
Mean time between licks in bursts	0.1	0.5	0.8	0.5	0.8	-0.6	-0.7	-0.9
Mean num. licks in bursts	0.3	0.9	1.7	-1.3	-0.9	1.0	0.9	-0.1
Cd content in liver	1.4	1.6	1.9	1.1	1.3	-1.2	-1.2	-1.4
Co content in liver	1.2	1.4	1.7	1.1	1.3	-1.2	-1.2	-1.2
Cu content in liver	0.0	0.1	0.2	0.2	-0.2	0.0	0.0	0.5
Fe content in liver	0.3	0.3	0.4	-0.5	-0.6	0.6	0.6	0.6
K content in liver	2.0	1.9	2.2	-1.3	-1.5	1.4	1.4	1.3
Mg content in liver	1.5	1.6	1.8	-1.2	-1.4	1.3	1.3	1.2
Mn content in liver	0.0	0.0	0.0	0.2	0.2	-0.1	-0.1	-0.1
Na content in liver	8.0	9.0	9.8	-2.8	-3.1	3.0	3.0	3.1
Rb content in liver	0.5	0.6	0.8	-0.9	-0.8	0.9	0.8	0.5
Se content in liver	0.0	0.0	0.1	0.1	0.2	-0.1	-0.1	-0.4
Sr content in liver	0.0	0.0	0.0	0.2	0.2	-0.2	-0.2	-0.1
Zn content in liver	0.0	0.1	0.1	-0.1	-0.3	0.2	0.2	0.3
Bone: minimum diameter	0.0	0.0	0.1	0.2	0.1	-0.3	-0.3	-0.2
Time in familiar zone, hab. session 1	0.1	0.1	0.5	0.4	0.0	-0.1	-0.0	0.7
Time in novel zone, hab. session 1	0.2	0.2	0.7	-0.1	0.3	-0.2	-0.3	-0.8
Total zone transitions, hab. session 1	0.4	0.5	1.2	1.1	0.6	-0.7	-0.7	0.2
Total locomotion distance, hab. session 1	0.0	0.1	0.2	0.4	0.1	-0.2	-0.2	0.3
Locomotion velocity, hab. session 1	0.0	0.0	0.1	0.1	-0.1	0.1	0.1	0.3
Time in familiar zone, hab. session 2	0.1	0.1	0.2	0.4	0.3	-0.2	-0.2	0.3
Time in novel zone, hab. session 2	0.1	0.1	0.3	-0.1	0.0	-0.1	-0.2	-0.5
Total zone transitions, hab. session 2	0.6	0.7	2.0	-0.3	-0.8	0.6	0.7	1.4
Total locomotion distance, hab. session 2	0.8	1.0	1.2	-0.9	-1.0	1.0	1.0	1.1
Locomotion velocity, hab. session 2	0.4	0.6	0.8	-0.6	-0.7	0.7	0.7	0.9
Novel to familiar place preference ratio	0.7	0.9	1.3	-1.2	-1.0	1.0	1.0	0.6
Novelty place preference	0.8	1.0	1.3	-1.1	-1.0	1.0	1.0	0.7
Time in novel zone, NPP test	1.0	1.2	1.5	-1.2	-1.1	1.1	1.1	0.8
Total zone transitions, NPP test	0.3	0.5	1.2	-0.3	-0.7	0.6	0.6	1.1
Total locomotion distance, NPP test	0.7	0.9	1.3	-0.8	-1.0	0.9	1.0	1.2
Locomotion velocity, NPP test	0.3	0.4	0.7	-0.4	-0.7	0.6	0.6	0.9
Intraocular pressure	0.0	0.0	0.0	-0.0	0.2	0.0	-0.0	-0.2
Delta distance traveled before/after self-admin	2.0	2.1	4.6	-0.7	-1.6	1.2	1.3	2.2
Delta ambulatory time before/after self-admin	0.6	1.1	2.7	-0.4	-1.1	0.7	0.8	1.6
Parametrial fat weight	0.9	2.0	3.0	1.7	1.5	-1.5	-1.5	-0.7
Pavlov. Cond. lever latency	0.1	0.2	0.2	0.4	0.4	-0.4	-0.4	-0.4
Pavlov. Cond. magazine entry latency	0.5	0.7	1.3	1.1	0.8	-0.9	-0.9	0.0
Pavlov. Cond. change in total contacts	0.1	0.1	0.4	-0.3	0.0	0.0	-0.0	-0.6
Pavlov. Cond. index score	0.4	0.5	0.7	0.8	0.7	-0.8	-0.7	-0.3
Pavlov. Cond. latency score	0.1	0.2	0.3	0.5	0.4	-0.4	-0.4	0.0
Pavlov. Cond. lever contacts	0.0	0.0	0.1	0.0	-0.1	0.1	0.1	0.4
Pavlov. Cond. magazine entry number	0.8	1.0	1.4	-1.2	-1.0	1.1	1.1	0.5
Pavlov. Cond. intertrial magazine entries	0.2	0.2	0.6	-0.1	-0.5	0.3	0.3	0.8
Pavlov. Cond. lever-magazine prob. diff.	0.2	0.2	0.4	0.6	0.5	-0.5	-0.5	-0.0
Pavlov. Cond. response bias	0.3	0.3	0.5	0.7	0.6	-0.7	-0.6	-0.2
Pavlov. Cond. lever latency	0.3	0.4	0.9	-0.9	-0.3	0.6	0.5	-0.4
Pavlov. Cond. magazine entry latency	2.8	3.9	4.5	2.1	2.0	-2.1	-2.0	-1.7
Pavlov. Cond. change in total contacts	0.2	0.5	0.7	0.9	0.6	-0.8	-0.8	-0.3
Pavlov. Cond. index score	0.7	1.0	1.8	1.3	0.9	-1.1	-1.1	-0.4
Pavlov. Cond. latency score	0.4	0.6	1.1	1.0	0.6	-0.9	-0.8	-0.3
Pavlov. Cond. lever contacts	0.2	0.3	0.8	0.9	0.2	-0.6	-0.5	0.4
Pavlov. Cond. magazine entry number	3.0	3.9	5.0	-2.2	-1.9	2.1	2.1	1.4
Pavlov. Cond. intertrial magazine entries	0.6	1.3	1.4	-1.1	-1.1	1.2	1.2	1.2
Pavlov. Cond. lever-magazine prob. diff.	0.8	1.2	2.1	1.5	1.0	-1.2	-1.2	-0.4
Pavlov. Cond. response bias	1.2	1.6	2.7	1.6	1.1	-1.4	-1.4	-0.5
Time in closed arm before self-admin	0.4	0.6	2.6	-0.3	0.5	-0.2	-0.4	-1.6
Time in closed arm after self-admin	0.8	1.0	1.9	0.5	1.1	-0.8	-0.9	-1.4
Time in open arm before self-admin	0.5	0.6	0.9	-0.6	-0.8	0.8	0.8	0.9
Time in open arm after self-admin	0.4	0.4	0.8	-0.4	-0.7	0.5	0.5	0.9
Bone: periosteal estimation	1.0	2.4	3.0	-1.4	-1.7	1.5	1.5	1.6
Bone: periosteal perimeter	1.6	3.2	3.8	-1.6	-2.0	1.7	1.8	1.8
Bone: post-yield work	0.0	0.1	0.1	-0.4	-0.3	0.3	0.3	0.1
Progressive ratio test 1 active lever presses	0.1	0.2	0.2	0.5	0.4	-0.4	-0.4	-0.3
Progressive ratio test 1 breakpoint	0.1	0.2	0.3	0.6	0.5	-0.5	-0.5	-0.4
Progressive ratio test 1 inactive lever presses	1.2	3.0	4.4	2.1	1.7	-1.9	-1.9	-0.9
Progressive ratio test 2 active lever presses	0.1	0.1	0.2	-0.5	-0.4	0.4	0.3	-0.1
Progressive ratio test 2 breakpoint	0.1	0.1	0.2	-0.4	-0.3	0.3	0.3	-0.1
Progressive ratio test 2 inactive lever presses	0.1	0.3	0.8	0.3	0.5	-0.5	-0.5	-0.9
Incentive Sensitization - Responses	0.1	0.3	0.6	-0.8	-0.4	0.5	0.4	-0.5
Incentive Sensitization - Breakpoint	0.1	0.2	0.5	-0.7	-0.3	0.4	0.3	-0.6
Sum of active levers in priming session hrs 5-6	0.1	0.1	0.1	-0.3	-0.3	0.4	0.3	-0.0
Progressive ratio	0.7	2.2	5.9	0.6	1.4	-1.1	-1.2	-2.4
Food seeking constrained by brief footshock	0.2	0.2	0.3	-0.4	-0.4	0.5	0.5	0.6
Seeking ratio, punishment vs. effort	2.9	6.4	11.7	-1.8	-2.5	2.3	2.4	3.4
Retroperitoneal fat weight	0.0	0.2	0.4	0.6	0.4	-0.4	-0.4	0.1
Reaction time number correct	0.6	2.1	2.5	-1.6	-1.4	1.5	1.5	1.1
Reaction time mean minus median	0.0	0.1	0.3	0.4	0.1	-0.3	-0.2	0.6
Reaction time mean minus median AUC	0.1	0.5	1.0	1.0	0.7	-0.8	-0.7	0.3
Reaction time num false alarms	0.4	0.6	0.9	0.9	0.9	-0.9	-0.8	-0.1
Reaction time num false alarms AUC	0.1	0.2	0.4	0.6	0.5	-0.5	-0.4	0.3
Reaction time trials correct on left	0.6	2.1	2.5	-1.6	-1.4	1.5	1.5	1.1
Reaction time trials on left	0.7	2.3	2.6	-1.6	-1.5	1.6	1.6	1.3
Reaction time mean	1.3	2.9	4.2	2.0	1.8	-1.9	-1.8	-0.7
Reaction time mean AUC	0.8	2.0	3.0	1.7	1.5	-1.6	-1.5	-0.5
Median of all reaction times	3.3	5.1	6.9	2.6	2.4	-2.4	-2.4	-1.3
Reaction time omissions	0.2	0.3	0.5	-0.4	-0.6	0.5	0.5	0.7
Reaction time false alarm rate	1.1	1.5	2.2	1.5	1.2	-1.4	-1.3	-0.5
Reaction time premature initiation rate	1.6	2.4	3.0	-1.5	-1.4	1.5	1.6	1.7
Reaction time premature initiations	1.3	4.0	4.4	-2.0	-1.8	2.0	2.0	2.1
Std. dev. reaction times	0.3	1.0	1.7	1.3	1.0	-1.1	-1.0	-0.1
Reaction time trials completed	0.7	2.3	2.6	-1.6	-1.5	1.6	1.6	1.3
Reaction time trials AUC	0.5	1.8	2.2	-1.5	-1.3	1.5	1.4	1.1
Run reversals in cocaine runway, females	0.0	0.0	0.1	0.3	-0.2	-0.2	-0.2	0.2
Run reversals in cocaine runway, males	0.1	0.1	0.1	-0.1	-0.2	0.2	0.2	0.3
Latency to leave start box in cocaine runway	1.6	2.2	3.5	-1.9	-1.5	1.6	1.5	0.6
Latency to leave start box in cocaine runway, F	0.5	0.7	1.3	-1.1	-0.8	0.9	0.8	0.2
Latency to leave start box in cocaine runway, M	4.6	4.4	5.6	-2.4	-2.2	2.3	2.2	1.2
Std. dev. time between licks in bursts	0.4	0.8	1.8	-0.4	-1.0	0.7	0.8	1.4
Total sessions with >9 infusions	0.2	0.2	0.5	0.7	0.3	-0.5	-0.4	0.2
Short access day 1 total inactive lever presses	0.4	0.8	1.0	0.8	1.0	-0.9	-0.9	-1.0
Short access day 10 total inactive lever presses	0.3	1.8	3.0	0.9	1.4	-1.2	-1.3	-1.7
Short access day 1 total infusions	0.2	0.3	0.6	0.3	0.6	-0.5	-0.5	-0.8
Short access day 10 total infusions	0.9	1.5	2.1	1.4	1.3	-1.3	-1.2	-0.7
Short access total infusions	0.4	0.6	1.0	1.0	0.8	-0.8	-0.8	-0.3
Short access day 1 locomotion	0.1	0.1	0.1	0.3	0.4	-0.3	-0.3	-0.2
Short access day 10 total locomotion	0.1	0.4	0.7	0.8	0.5	-0.6	-0.6	-0.0
Short access total locomotion	0.3	0.5	0.6	0.8	0.8	-0.8	-0.7	-0.5
One hour access (0.3 mA shock)	0.6	0.7	0.9	-0.9	-0.9	0.9	0.9	0.5
Compulsive drug intake	1.4	2.0	2.6	-1.2	-1.5	1.4	1.4	1.6
One hour access (shock baseline)	0.1	0.3	0.6	0.4	0.6	-0.5	-0.6	-0.8
Social response proportion	0.4	0.5	1.5	0.3	0.5	-0.5	-0.5	-1.2
Social responses	0.0	0.0	0.1	0.1	-0.3	0.1	0.1	0.3
Social time	0.1	0.1	0.6	-0.2	0.0	-0.0	-0.1	-0.8
Soleus weight	15.9	47.0	50.7	-7.0	-7.1	7.1	7.1	5.9
Bone: stiffness	0.6	1.2	1.6	-0.9	-1.3	1.0	1.0	1.1
Tibialis anterior weight	13.0	44.8	48.4	-6.9	-6.9	7.0	7.0	5.6
Time to tail flick, vehicle, before self-admin	0.1	0.2	0.4	0.6	0.4	-0.4	-0.4	0.1
Time to tail flick, vehicle, after self-admin	1.2	2.5	8.1	0.4	1.3	-1.0	-1.2	-2.8
Time to tail flick, test, before self-admin	1.5	1.8	2.8	1.7	1.3	-1.4	-1.4	-0.7
Time to tail flick, test, after self-admin	4.4	4.6	10.0	1.0	2.4	-1.7	-1.9	-3.2
Delta time to tail flick, vehicle, before/after SA	1.5	1.6	4.6	0.4	1.1	-0.9	-1.0	-2.2
Delta time to tail flick, test, before/after SA	0.2	0.3	0.7	-0.7	0.2	0.2	0.1	-0.9
Tibia length	0.1	0.2	0.6	0.2	0.4	-0.4	-0.4	-0.8
Ambulatory time before self-admin	0.1	0.4	1.8	-0.2	0.5	-0.2	-0.3	-1.3
Ambulatory time after self-admin	0.3	0.5	0.6	-0.8	-0.8	0.7	0.7	0.5
Bone: tissue strength	1.3	1.4	1.5	1.2	1.2	-1.2	-1.2	-0.9
Total heroin consumption	1.0	1.2	2.2	-1.5	-0.8	1.3	1.2	0.2
Bone: trabecular number	1.0	2.0	2.9	1.7	1.4	-1.5	-1.5	-0.8
Bone: trabecular spacing	0.0	0.0	0.1	-0.3	-0.1	0.2	0.2	-0.1
Bone: trabecular thickness	0.4	0.6	0.6	0.8	0.8	-0.8	-0.8	-0.6
Bone: trabecular tissue density	3.9	6.8	8.3	-2.3	-2.6	2.6	2.6	2.9
Water consumed over 24 hours	0.2	0.4	0.9	0.3	0.6	-0.6	-0.6	-0.9
Number of responses in last shaping day	0.3	0.4	1.4	-0.1	0.4	-0.2	-0.3	-1.2