Hub : Genes

Fads1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	OFC	intron excision ratio	chr1_206829847_206830817	0.18	0.12	1.0e-03	-0.01	0.07	0.04	0.02	5.9e-01	1.0e-02	5.3e-02	9.4e-02
2	IL	gene expression	Fads1	0.65	0.16	7.8e-08	0.14	0.05	0.13	0.02	2.6e-04	2.3e-02	5.0e-04	1.2e-01
3	OFC	gene expression	Fads1	0.74	0.15	1.9e-08	0.16	0.04	0.15	0.04	1.3e-04	4.8e-02	2.2e-04	3.3e-02
4	NAcc	gene expression	Fads1	0.36	0.1	0.0e+00	0.31	0.32	0.31	0.31	3.3e-36	2.3e-37	6.1e-37	9.4e-37
5	Eye	alternative TSS	XM_006231075.4	0.41	0.19	1.3e-03	0.11	0.09	0.02	0.01	8.6e-03	1.6e-02	1.4e-01	2.0e-01
6	PL	gene expression	Fads1	0.68	0.09	0.0e+00	0.46	0.47	0.48	0.46	1.4e-55	9.9e-58	1.2e-58	2.0e-56
7	RMTg	gene expression	Fads1	0.24	0.14	2.0e-03	0.04	0.03	0.05	0.03	3.8e-02	4.9e-02	2.1e-02	5.2e-02
8	BLA	gene expression	Fads1	0.71	0.13	0.0e+00	0.36	0.36	0.37	0.38	1.8e-20	5.4e-20	9.8e-21	1.2e-21
9	Adipose	gene expression	Fads1	0.12	0.06	1.6e-08	0.03	0.06	0.06	0.06	2.8e-04	2.3e-07	3.2e-07	4.0e-07
10	Brain	gene expression	Fads1	0.83	0.03	0.0e+00	0.51	0.2	0.58	0.3	3.2e-54	3.8e-18	1.1e-65	4.7e-28
11	pVTA	gene expression	Fads1	0.41	0.13	1.8e-12	0.22	0.23	0.22	0.22	4.3e-10	3.7e-10	8.9e-10	7.9e-10
12	Liver	gene expression	Fads1	0.16	0.07	2.0e-10	0.06	0.08	0.07	0.07	1.0e-06	2.5e-09	3.7e-08	1.9e-08
13	Eye	gene expression	Fads1	0.65	0.14	7.1e-04	0.15	0.1	0.16	0.15	2.7e-03	1.5e-02	1.7e-03	2.5e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12	13
Bone: apparent density	0.4	0.7	1.2	0.1	-0.6	-0.6	0.7	0.8	-0.7	-1.0	0.8	1.1	-0.7	1.0	1.0	-0.9
Area under the delay curve	0.6	0.6	1.2	0.3	-0.5	-0.5	0.7	0.8	-0.7	-0.9	0.7	1.1	-0.6	1.1	1.1	-0.7
BMI with tail	1.9	6.2	14.6	-1.6	-1.3	-1.3	1.7	1.1	-1.6	-3.1	2.2	3.3	-2.7	3.4	3.8	-3.1
BMI without tail	0.3	0.6	1.8	-1.4	0.1	0.1	0.2	-0.1	-0.0	-0.8	0.4	0.9	-0.6	1.0	1.2	-0.9
Body weight	0.7	3.0	8.8	-3.0	0.7	0.7	0.0	-0.4	0.4	-2.1	0.4	2.2	-0.7	2.2	2.9	-2.4
Weight adjusted by age	0.4	0.4	2.8	-1.7	0.6	0.6	-0.4	-0.9	0.5	-0.2	-0.2	0.1	-0.3	0.2	0.6	-0.7
Bone surface	0.6	1.0	2.5	-0.6	-0.5	-0.5	0.4	0.7	-0.4	-1.3	0.6	1.6	-0.6	1.3	1.6	-1.5
Bone volume	0.6	1.0	2.1	-0.0	-0.8	-0.8	0.7	0.8	-0.7	-1.4	0.8	1.4	-0.7	1.2	1.4	-1.4
Breakpoint value in progressive ratio session	2.3	2.6	4.3	-2.1	1.8	1.8	-2.0	-1.9	2.0	1.1	-1.8	-1.2	1.6	-1.3	-0.9	0.6
Number of licking bursts	0.1	0.1	0.3	0.2	-0.1	-0.1	0.3	0.3	-0.1	-0.6	0.1	0.3	-0.0	0.4	0.4	-0.6
Context. condit. distance diff. score	0.2	0.2	0.4	0.3	-0.5	-0.5	0.6	-0.1	-0.4	-0.5	0.5	0.2	-0.6	0.4	0.3	-0.3
Locomotion velocity, session 1	0.1	0.1	0.4	-0.5	-0.1	-0.1	-0.2	-0.6	-0.1	0.5	0.3	-0.1	-0.4	-0.2	-0.1	0.6
Locomotion distance, session 1	0.2	0.2	1.1	-1.1	0.1	0.1	-0.1	-0.6	-0.1	0.1	0.5	0.4	-0.7	0.4	0.6	0.1
Locomotion velocity, session 2	0.5	0.6	2.8	-1.7	0.7	0.7	-0.4	-0.7	0.5	-0.5	-0.1	0.7	-0.1	0.6	1.0	-0.8
Locomotion distance, session 2	0.2	0.2	1.1	-1.1	0.5	0.5	-0.4	-0.8	0.4	0.4	-0.1	-0.2	-0.1	-0.0	0.1	0.3
Locomotion velocity, session 3	2.2	2.6	4.7	0.2	-1.2	-1.2	1.6	0.8	-1.3	-2.2	1.6	2.0	-1.8	2.1	2.1	-1.9
Locomotion distance, session 3	0.1	0.1	0.2	0.2	-0.4	-0.4	0.3	0.0	-0.3	-0.4	0.4	0.4	-0.3	0.3	0.3	-0.1
Stereotopy head waving bouts, day 3	1.6	1.9	2.9	0.4	-1.5	-1.5	1.4	1.1	-1.4	-1.3	1.5	1.5	-1.6	1.7	1.6	-1.1
Stereotopy head waving duration, day 3	0.7	0.8	1.5	0.2	-0.8	-0.8	1.0	0.5	-0.7	-1.1	0.8	1.0	-0.9	1.2	1.1	-0.9
Locomotion velocity, session 7	0.3	0.3	0.7	0.4	-0.4	-0.4	0.5	0.3	-0.3	-0.9	0.4	0.7	-0.3	0.8	0.7	-0.7
Locomotion distance, session 7	0.2	0.3	0.5	0.4	-0.5	-0.5	0.7	0.3	-0.5	-0.6	0.6	0.5	-0.5	0.7	0.6	-0.4
Stereotopy head waving bouts, day 7	0.1	0.1	0.4	-0.3	-0.3	-0.3	0.1	0.0	-0.1	-0.5	0.2	0.5	-0.3	0.5	0.6	-0.6
Stereotopy head waving duration, day 7	0.3	0.4	1.7	-1.3	0.4	0.4	-0.5	-0.4	0.6	-0.4	-0.3	0.5	0.2	0.4	0.7	-0.7
Locomotion velocity, session 8	0.4	0.5	0.9	-0.4	0.7	0.7	-0.7	-1.0	0.7	0.8	-0.7	-0.7	0.8	-0.7	-0.7	0.9
Locomotion distance, session 8	0.3	0.5	0.9	0.3	-0.7	-0.7	0.8	0.4	-0.7	-0.6	0.9	0.7	-1.0	0.8	0.7	-0.5
Degree of sensitization distance	1.2	1.2	1.8	0.2	-0.9	-0.9	1.2	0.9	-1.1	-1.1	1.1	1.2	-1.4	1.3	1.3	-1.1
Degree of sensitization stereotypy	0.2	0.2	0.9	-0.9	0.3	0.3	-0.5	-0.3	0.4	-0.3	-0.4	0.3	0.2	0.1	0.4	-0.6
Conditioned locomotion	0.2	0.2	0.7	-0.9	0.5	0.5	-0.4	-0.6	0.5	0.1	-0.4	0.0	0.3	0.1	0.2	-0.0
Cocaine response after cond. corrected	0.2	0.2	0.6	0.3	-0.3	-0.3	0.6	0.1	-0.6	0.2	0.6	-0.0	-0.8	0.2	0.0	0.4
Cocaine response after cond. not corrected	0.3	0.3	0.9	0.5	-0.6	-0.6	0.6	0.5	-0.8	0.1	0.8	0.2	-1.0	0.2	0.1	0.1
Cocaine response before conditioning	0.0	0.0	0.2	-0.1	-0.1	-0.1	-0.4	0.3	-0.0	-0.1	-0.1	0.1	0.2	-0.4	-0.1	-0.3
Saline control response	1.0	1.4	3.7	-1.9	1.5	1.5	-1.4	-1.7	1.3	0.8	-1.0	-0.5	0.9	-0.6	-0.2	0.5
Bone: connectivity density	0.4	0.7	1.8	-0.9	-0.3	-0.3	0.3	0.4	-0.3	-1.0	0.6	1.2	-0.6	1.1	1.3	-1.1
Bone: cortical apparent density	0.7	0.9	1.5	-1.0	1.2	1.2	-1.1	-1.1	1.1	0.6	-1.1	-0.7	1.0	-0.8	-0.6	0.5
Bone: cortical area	0.1	0.1	0.3	-0.6	0.1	0.1	-0.2	-0.0	0.1	-0.4	0.1	0.6	-0.0	0.3	0.5	-0.5
Bone: cortical porosity	0.8	0.8	1.4	-0.4	0.8	0.8	-0.9	-1.2	1.0	1.0	-1.0	-0.9	1.0	-0.9	-0.9	0.9
Bone: cortical porosity	1.3	1.4	2.3	-0.8	1.2	1.2	-1.2	-1.5	1.3	1.2	-1.3	-1.1	1.2	-1.0	-1.0	1.1
Bone: cortical thickness	2.3	3.8	6.2	-2.5	2.3	2.3	-2.4	-2.4	2.3	1.6	-2.0	-1.2	2.0	-1.5	-1.0	1.2
Bone: cortical thickness	0.9	1.0	1.4	-0.9	1.2	1.2	-1.1	-1.2	1.2	0.7	-1.0	-0.9	1.1	-0.9	-0.8	0.8
Bone: cortical tissue density	0.9	1.2	1.9	-1.2	1.4	1.4	-1.3	-1.2	1.2	0.7	-1.2	-0.8	1.1	-0.9	-0.6	0.5
Condit. Reinf. active minus inactive responses	0.2	0.2	1.4	-1.2	0.4	0.4	-0.5	-0.6	0.3	0.4	-0.0	-0.0	-0.2	-0.2	0.1	0.2
Condit. Reinf. active-inactive response ratio	0.9	1.0	2.1	-1.3	0.9	0.9	-1.1	-1.0	0.9	1.4	-0.7	-1.0	0.5	-1.1	-0.8	1.1
Condit. Reinf. active responses	0.2	0.3	0.8	-0.9	-0.1	-0.1	0.1	-0.1	-0.3	-0.4	0.6	0.7	-0.9	0.5	0.8	-0.6
Condit. Reinf. inactive responses	1.3	1.6	2.6	0.6	-1.1	-1.1	1.3	0.9	-1.2	-1.6	1.4	1.4	-1.4	1.3	1.3	-1.4
Incentive salience index mean	0.2	0.3	0.8	-0.9	-0.1	-0.1	0.0	-0.0	-0.3	-0.4	0.6	0.7	-0.7	0.5	0.8	-0.5
Condit. Reinf. lever presses	0.7	1.0	1.9	-0.1	-0.7	-0.7	0.7	0.7	-0.8	-1.3	1.0	1.4	-1.0	1.2	1.3	-1.1
Condit. Reinf. active minus inactive responses	0.1	0.1	0.2	0.4	-0.4	-0.4	0.1	0.2	-0.4	0.2	0.1	-0.1	-0.3	-0.3	-0.2	0.2
Condit. Reinf. active-inactive response ratio	1.0	1.1	1.5	0.8	-1.2	-1.2	1.1	1.0	-1.1	-1.2	0.8	0.8	-1.0	0.9	0.9	-1.2
Condit. Reinf. active responses	0.0	0.0	0.1	-0.0	-0.1	-0.1	-0.1	-0.3	-0.2	0.4	0.1	-0.1	-0.2	-0.3	-0.2	0.3
Condit. Reinf. inactive responses	0.3	0.4	1.4	-0.2	0.5	0.5	-0.6	-0.7	0.2	1.2	-0.2	-0.5	0.3	-0.8	-0.8	1.1
Condit. Reinf. lever presses	0.2	0.3	1.1	-0.6	-0.1	-0.1	0.1	0.1	-0.2	-0.7	0.3	0.7	-0.4	0.5	0.8	-1.0
Condit. Reinf. lever reinforcers received	0.1	0.1	0.3	-0.4	0.2	0.2	-0.4	-0.6	0.1	0.4	-0.2	-0.2	0.1	-0.4	-0.2	0.3
Conditioned reinforcement - actives	0.5	0.5	1.3	1.1	-1.0	-1.0	0.4	0.5	-0.6	0.5	0.4	-0.4	-0.4	-0.5	-0.7	0.6
Conditioned reinforcement - inactives	1.2	1.4	2.4	1.2	-1.5	-1.5	1.3	1.3	-1.4	-0.9	1.2	0.9	-1.2	0.8	0.7	-0.7
Conditioned locomotion	2.0	2.4	4.7	1.7	-2.2	-2.2	1.8	1.7	-1.9	-1.0	1.6	1.1	-1.5	1.1	0.8	-0.7
Patch foraging indifference point 0 sec	0.1	0.2	0.7	-0.8	0.5	0.5	-0.5	-0.6	0.5	-0.1	-0.5	0.1	0.4	0.1	0.3	-0.1
Patch foraging indifference point AUC	0.6	0.7	2.1	-1.4	1.1	1.1	-1.1	-0.8	1.0	0.2	-0.9	-0.1	0.8	-0.3	0.1	-0.1
Delay disc. indifference point, 0s delay	2.1	2.3	3.3	0.7	-1.5	-1.5	1.7	1.6	-1.6	-1.4	1.7	1.6	-1.7	1.8	1.6	-1.1
Delay disc. indifference point, 16s delay	0.4	0.4	0.7	0.1	-0.4	-0.4	0.5	0.6	-0.5	-0.8	0.5	0.9	-0.6	0.8	0.8	-0.8
Delay disc. indifference point, 2s delay	1.8	2.0	2.9	1.0	-1.4	-1.4	1.4	1.7	-1.5	-1.3	1.5	1.6	-1.4	1.5	1.4	-1.1
Delay disc. indifference point, 24s delay	0.1	0.1	0.2	-0.0	-0.2	-0.2	0.3	0.2	-0.2	-0.2	0.3	0.4	-0.2	0.5	0.4	-0.2
Delay disc. indifference point, 4s delay	0.6	0.6	1.7	-0.0	-0.3	-0.3	0.7	0.5	-0.5	-1.1	0.7	1.2	-0.6	1.3	1.3	-0.8
Delay disc. indifference point, 8s delay	0.1	0.1	0.3	0.6	-0.2	-0.2	0.4	0.4	-0.2	-0.3	0.2	0.3	0.0	0.5	0.3	-0.0
Indifference point function ln k	2.5	3.5	6.2	2.4	-2.5	-2.5	2.4	1.6	-2.2	-1.1	2.1	1.0	-2.1	1.3	0.7	-0.5
Indifference point function log k	2.5	3.5	6.2	2.4	-2.5	-2.5	2.4	1.6	-2.2	-1.1	2.1	1.0	-2.1	1.3	0.7	-0.5
Patch foraging total patch changes 0 sec	0.2	0.4	0.9	-0.9	0.7	0.7	-0.7	-0.9	0.8	0.3	-0.7	-0.2	0.7	-0.2	-0.1	0.2
Patch foraging total patch changes 12 sec	3.0	3.8	9.9	-3.1	2.6	2.6	-2.3	-2.3	2.4	0.8	-2.2	-0.8	1.9	-0.9	-0.2	0.2
Patch foraging total patch changes 18 sec	0.6	0.7	1.2	-1.0	1.0	1.0	-1.1	-0.9	0.9	0.8	-0.9	-0.6	0.9	-0.7	-0.5	0.6
Patch foraging total patch changes 24 sec	1.3	1.6	7.0	-2.6	1.3	1.3	-1.1	-1.4	1.4	-0.7	-0.9	0.7	0.7	0.6	1.3	-1.1
Patch foraging total patch changes 6 sec	0.2	0.3	0.8	-0.9	0.8	0.8	-0.4	-0.6	0.5	-0.5	-0.4	0.4	0.4	0.3	0.6	-0.6
Patch foraging time to switch 0 sec	0.5	0.8	1.8	-0.2	-0.4	-0.4	0.6	0.6	-0.6	-1.2	0.8	1.2	-0.8	1.1	1.2	-1.3
Patch foraging water rate 0 sec	0.2	0.3	1.0	0.6	-0.0	-0.0	-0.3	-0.3	0.1	0.7	-0.3	-0.8	0.4	-0.8	-1.0	1.0
Patch foraging water rate 12 sec	0.3	0.5	1.8	1.3	-1.1	-1.1	0.8	0.5	-0.8	0.1	0.6	-0.3	-0.5	-0.1	-0.5	0.6
Patch foraging water rate 18 sec	0.3	0.4	0.9	0.9	-1.0	-1.0	0.8	0.5	-0.8	-0.2	0.8	0.2	-0.7	0.3	0.0	0.2
Patch foraging water rate 24 sec	0.2	0.3	1.3	1.2	-0.5	-0.5	0.5	0.3	-0.4	0.2	0.3	-0.5	-0.2	-0.3	-0.7	0.5
Patch foraging water rate 6 sec	0.2	0.3	1.0	1.0	-0.6	-0.6	0.3	0.1	-0.3	0.4	0.2	-0.5	-0.1	-0.3	-0.7	0.8
Seeking ratio, delayed vs. immediate footshock	0.3	0.3	0.6	0.2	-0.5	-0.5	0.6	0.3	-0.4	-0.7	0.5	0.7	-0.5	0.8	0.7	-0.7
Distance traveled before self-admin	0.4	0.5	1.8	-1.3	0.9	0.9	-0.8	-0.8	0.8	-0.1	-0.4	0.1	0.4	-0.1	0.3	-0.5
Distance traveled after self-admin	0.0	0.0	0.1	-0.4	0.2	0.2	-0.3	-0.1	0.2	-0.0	-0.1	0.1	0.2	-0.1	0.1	-0.2
Extensor digitorum longus weight	1.0	4.1	19.3	-4.4	2.1	2.1	-1.3	-2.2	1.7	-1.3	-0.8	1.4	0.2	1.4	2.4	-2.0
Bone: elastic displacement	1.1	1.3	3.4	0.0	0.7	0.7	-0.9	-1.0	0.7	1.5	-0.8	-1.4	0.9	-1.4	-1.5	1.8
Bone: elastic work	1.4	1.8	2.7	-1.4	1.5	1.5	-1.5	-1.6	1.4	1.4	-1.2	-1.1	1.2	-1.1	-0.9	1.3
Bone: endosteal estimation	3.8	8.2	10.3	2.6	-3.2	-3.2	3.2	3.2	-3.1	-2.8	3.0	2.6	-2.9	2.6	2.2	-2.4
Bone: endosteal perimeter	4.9	10.1	12.7	3.1	-3.6	-3.6	3.6	3.4	-3.4	-3.2	3.3	2.8	-3.1	2.8	2.3	-2.8
Epididymis fat weight	1.7	4.0	5.3	1.7	-2.0	-2.0	2.3	2.1	-2.0	-2.3	2.1	2.0	-1.9	2.1	1.8	-1.9
Delta time in closed arm before/after self-admin	0.9	0.8	3.1	-1.8	1.2	1.2	-0.7	-1.4	1.1	0.3	-0.5	-0.3	0.4	0.1	0.2	0.1
Delta time in open arm before/after self-admin	0.5	0.5	1.4	-1.2	0.9	0.9	-0.9	-0.8	0.9	0.1	-0.9	-0.2	0.6	-0.4	-0.0	-0.4
Diff in mean of infusions in LGA sessions	2.5	2.8	4.0	-1.9	2.0	2.0	-1.9	-1.9	2.0	1.2	-2.0	-1.3	1.8	-1.4	-1.0	0.7
Delay discount exponential model param	0.6	0.6	1.2	-0.3	0.6	0.6	-0.8	-0.8	0.7	0.9	-0.7	-1.1	0.6	-1.1	-1.1	0.7
Extinction: sum of active levers before priming	0.9	0.9	3.4	-1.8	1.2	1.2	-1.1	-1.2	1.3	-0.0	-0.9	-0.0	0.7	-0.1	0.3	-0.4
Active lever presses in extinction session 6	2.0	1.9	3.3	-1.7	1.8	1.8	-1.8	-1.7	1.8	0.7	-1.2	-0.8	1.4	-1.1	-0.6	0.3
Bone: final force	0.2	0.3	1.6	-1.3	0.3	0.3	-0.2	-0.4	0.2	-0.5	0.2	0.7	-0.2	0.5	0.9	-0.7
Bone: final moment	0.2	0.3	1.5	-1.2	0.3	0.3	-0.3	-0.5	0.1	-0.5	0.1	0.7	-0.2	0.5	0.8	-0.6
Food consumed during 24 hour testing period	0.1	0.1	0.4	0.4	-0.2	-0.2	-0.2	0.0	-0.1	0.5	0.0	-0.4	0.1	-0.6	-0.6	0.6
Glucose	2.5	3.8	6.6	2.5	-2.5	-2.5	2.2	2.6	-2.4	-1.0	2.1	1.2	-1.9	1.3	0.8	-0.6
Heart weight	0.7	1.1	2.1	1.2	-1.2	-1.2	1.4	1.5	-1.1	-0.7	1.0	0.7	-0.9	1.0	0.6	-0.4
Delay discount hyperbolic model param	0.8	0.8	1.5	-0.3	0.7	0.7	-0.8	-0.9	0.8	1.0	-0.9	-1.2	0.7	-1.2	-1.2	0.8
Intermittent access intake day 1-15 change	0.5	0.5	1.5	0.7	0.2	0.2	-0.4	-0.2	0.2	0.9	-0.4	-0.9	0.5	-1.1	-1.2	1.1
Intermittent access intake escalation	0.4	0.4	1.0	0.4	0.2	0.2	-0.4	-0.2	0.2	0.8	-0.3	-0.8	0.4	-0.9	-1.0	0.9
Intermittent access intake escalation 2	0.6	0.6	1.0	-0.2	0.8	0.8	-0.9	-0.7	0.7	0.7	-0.7	-0.8	0.7	-1.0	-0.9	0.6
Intermitt. access day 1 inactive lever presses	3.3	3.5	5.7	1.6	-2.2	-2.2	2.1	2.4	-2.2	-1.6	1.9	1.6	-1.9	1.6	1.4	-1.4
Intermitt. access day 15 inactive lever presses	3.6	4.0	5.4	0.7	-1.9	-1.9	1.9	2.1	-2.0	-2.2	1.9	2.3	-2.1	2.2	2.2	-2.1
Intermitt. access escalation Index	1.1	0.9	1.7	0.8	-0.7	-0.7	1.1	1.3	-1.0	-0.9	1.0	1.0	-1.0	1.1	0.9	-0.7
Intermittent access day 1 total infusions	6.6	7.7	9.2	1.7	-3.0	-3.0	3.0	2.6	-2.9	-2.7	2.8	2.9	-3.0	2.9	2.7	-2.3
Intermittent access day 15 total infusions	3.0	3.4	5.6	2.2	-2.4	-2.4	2.1	2.0	-2.2	-1.2	2.0	1.4	-2.0	1.3	0.9	-0.7
Intermittent access terminal intake (last 3 days)	2.2	2.4	3.3	1.2	-1.8	-1.8	1.6	1.5	-1.7	-1.4	1.7	1.5	-1.8	1.4	1.3	-1.2
Intermittent access total infusions	3.3	3.6	4.8	1.5	-2.2	-2.2	2.1	1.9	-2.1	-1.8	2.0	1.9	-2.1	1.8	1.6	-1.4
Intermittent access day 1 locomotion	6.2	6.5	8.4	1.0	-2.7	-2.7	2.7	2.3	-2.5	-2.6	2.6	2.8	-2.7	2.9	2.8	-2.4
Intermittent access day 15 total locomotion	2.9	3.1	3.8	0.7	-2.0	-2.0	1.8	1.6	-1.8	-1.9	1.8	1.9	-1.9	1.9	1.9	-1.7
Intermittent access total locomotion	8.0	9.1	11.2	1.3	-3.2	-3.2	3.0	2.8	-3.0	-3.2	3.0	3.3	-3.2	3.3	3.2	-2.9
Intermittent access standard deviation	0.9	0.9	2.3	0.3	0.4	0.4	-0.6	-0.9	0.5	1.3	-0.6	-1.4	0.5	-1.4	-1.5	1.3
Left kidney weight	0.7	1.9	3.4	0.5	-1.1	-1.1	1.3	1.7	-1.1	-1.9	1.0	1.6	-0.9	1.7	1.7	-1.7
Right kidney weight	0.5	1.3	2.3	0.2	-0.8	-0.8	1.0	1.4	-0.8	-1.5	0.8	1.4	-0.9	1.4	1.5	-1.5
Cocaine induced anxiety	0.1	0.1	0.4	-0.7	0.3	0.3	-0.4	-0.2	0.3	0.2	-0.2	-0.1	0.1	-0.2	-0.0	-0.1
Post-drug Anxiety	0.1	0.1	0.8	-0.9	0.3	0.3	-0.4	-0.3	0.3	0.1	-0.2	-0.0	-0.0	-0.1	0.1	-0.1
Baseline Anxiety	0.2	0.3	1.2	-1.1	0.6	0.6	-0.5	-0.8	0.6	0.1	-0.4	-0.1	0.4	-0.1	0.2	0.0
Tail length	1.0	3.0	5.1	-2.0	2.3	2.3	-1.9	-2.0	2.1	1.2	-1.9	-1.3	1.9	-1.2	-0.9	0.9
Length with tail	0.4	1.6	5.7	-2.4	1.6	1.6	-1.0	-1.2	1.4	-0.7	-1.0	0.6	0.9	0.5	1.0	-1.0
Length without tail	0.4	0.8	2.2	-1.2	0.3	0.3	-0.0	-0.0	0.2	-1.2	0.1	1.3	-0.2	1.1	1.5	-1.4
Times rat made contact with spout	0.9	1.0	1.6	-0.8	1.0	1.0	-1.0	-1.2	1.0	1.3	-0.9	-1.1	0.9	-1.0	-1.0	1.1
Lifetime Intake	2.8	3.2	4.3	1.3	-2.1	-2.1	2.0	1.6	-2.0	-1.6	2.0	1.7	-2.1	1.7	1.5	-1.2
Liver weight, left	0.1	0.1	0.7	0.8	-0.3	-0.3	0.2	0.3	-0.3	0.4	0.1	-0.2	0.1	-0.3	-0.5	0.6
Liver weight, right	0.2	0.4	0.9	0.3	-0.8	-0.8	0.6	0.4	-0.8	-0.1	1.0	0.6	-0.9	0.5	0.4	0.1
Locomotor activity	0.3	0.4	1.5	0.5	0.2	0.2	-0.3	0.3	0.1	1.0	-0.2	-0.8	0.5	-0.7	-0.9	1.2
Locomotor testing distance	0.2	0.3	1.1	0.6	-0.3	-0.3	0.2	0.6	-0.4	0.7	0.3	-0.4	-0.1	-0.3	-0.5	1.0
Locomotor testing rearing	0.2	0.4	1.1	0.8	-0.4	-0.4	0.2	0.2	-0.5	0.9	0.3	-0.6	-0.3	-0.6	-0.8	1.1
Locomotion in novel chamber	1.9	2.3	4.1	2.0	-1.8	-1.8	1.6	1.9	-1.8	-1.2	1.7	1.1	-1.5	1.0	0.7	-0.8
Locomotion in novel chamber post-restriction	0.4	0.5	1.3	1.0	-0.1	-0.1	-0.0	0.1	-0.0	0.9	-0.2	-1.0	0.3	-0.8	-1.1	1.1
Fecal boli incidents, locomotor time 1	0.1	0.1	0.2	0.4	-0.4	-0.4	0.2	0.3	-0.4	0.0	0.1	-0.1	-0.3	-0.2	-0.2	-0.2
Change in fecal boli incidents, locomotor task	1.3	1.2	1.8	1.0	-1.3	-1.3	1.4	1.3	-1.3	-0.6	1.4	0.9	-1.1	1.1	0.7	-0.1
Time >=10cm from walls, locomotor time 1	2.3	2.3	3.4	1.8	-1.7	-1.7	1.7	1.8	-1.7	-1.4	1.5	1.1	-1.5	1.1	0.8	-1.3
Bouts of movement, locomotor time 1	4.5	4.9	6.4	-1.5	2.4	2.4	-2.4	-2.5	2.5	2.0	-2.3	-2.3	2.4	-2.3	-2.1	1.5
Total resting periods, locomotor time 1	2.8	3.1	4.4	-1.2	1.9	1.9	-1.9	-2.1	2.0	1.5	-1.8	-1.7	1.9	-1.8	-1.6	1.1
Rest time, locomotor task time 1	0.2	0.2	1.0	1.0	-0.1	-0.1	0.1	0.0	-0.0	0.2	-0.2	-0.5	0.3	-0.4	-0.6	0.4
Distance moved, locomotor task time 1	0.3	0.3	0.5	-0.3	-0.3	-0.3	0.4	0.3	-0.4	-0.6	0.6	0.7	-0.7	0.7	0.7	-0.6
Vertical activity count, locomotor time 1	0.2	0.2	0.7	0.8	-0.6	-0.6	0.4	0.7	-0.6	-0.0	0.5	0.0	-0.4	0.1	-0.2	0.2
Time >=10cm from walls, locomotor time 2	0.1	0.1	0.3	0.4	-0.2	-0.2	-0.1	0.2	-0.0	0.3	-0.3	-0.4	0.3	-0.5	-0.5	0.1
Bouts of movement, locomotor time 2	1.2	1.3	3.5	-1.9	1.2	1.2	-1.3	-1.7	1.3	0.9	-1.1	-0.9	0.7	-0.8	-0.5	0.3
Total resting periods, locomotor time 2	0.8	0.9	2.3	-1.5	1.0	1.0	-1.0	-1.4	1.1	0.8	-0.9	-0.9	0.5	-0.7	-0.4	0.3
Rest time, locomotor task time 2	0.4	0.5	2.3	1.5	-0.9	-0.9	0.9	0.7	-0.7	-0.0	0.5	-0.2	-0.6	0.0	-0.3	0.3
Distance moved, locomotor task time 2	0.6	0.7	1.2	-0.7	1.1	1.1	-1.0	-0.7	0.9	0.5	-0.8	-0.6	1.0	-0.8	-0.6	0.4
Vertical activity count, locomotor time 2	1.4	1.6	2.3	-0.3	1.2	1.2	-1.3	-0.7	1.1	1.5	-1.2	-1.4	1.4	-1.4	-1.5	1.5
Light reinforcement 1	0.1	0.2	0.5	0.3	-0.2	-0.2	-0.2	0.3	-0.1	0.7	-0.1	-0.4	0.2	-0.6	-0.6	0.6
Light reinforcement 2	1.2	1.7	2.9	1.2	-1.7	-1.7	1.2	1.7	-1.3	-1.3	1.0	1.2	-0.9	1.0	0.9	-1.3
Bone: marrow area	3.8	8.2	10.5	2.7	-3.2	-3.2	3.2	3.2	-3.1	-2.7	3.0	2.5	-2.9	2.6	2.1	-2.4
Bone: maximum diameter	0.6	1.0	2.1	0.3	-0.9	-0.9	0.9	0.9	-0.8	-1.4	0.9	1.3	-0.8	1.1	1.2	-1.4
Bone: maximum force	1.0	1.7	4.2	-1.0	-0.5	-0.5	0.6	0.5	-0.6	-1.8	1.0	1.9	-1.1	1.7	2.1	-2.0
Bone: maximum moment	0.9	1.5	3.7	-1.0	-0.4	-0.4	0.6	0.4	-0.5	-1.7	0.9	1.8	-1.0	1.6	1.9	-1.8
Mean time between licks in bursts	0.4	0.6	1.8	-1.2	0.9	0.9	-0.6	-1.4	0.8	0.7	-0.4	-0.5	0.2	-0.3	-0.2	0.6
Mean num. licks in bursts	0.9	1.1	2.5	-0.5	0.7	0.7	-1.0	-1.0	0.7	1.6	-0.7	-1.3	0.7	-1.3	-1.3	1.5
Cd content in liver	0.3	0.4	1.0	1.0	-0.6	-0.6	0.3	0.6	-0.7	0.6	0.5	-0.2	-0.5	-0.3	-0.5	0.8
Co content in liver	1.6	1.8	4.4	0.7	0.5	0.5	-0.8	-0.7	0.6	1.9	-1.0	-1.9	1.1	-1.8	-2.1	2.1
Cu content in liver	0.2	0.2	0.4	-0.6	0.6	0.6	-0.4	-0.6	0.6	0.4	-0.6	-0.3	0.5	-0.1	-0.1	0.2
Fe content in liver	0.0	0.0	0.0	-0.1	-0.1	-0.1	0.2	-0.1	-0.1	-0.2	0.1	0.1	-0.2	0.2	0.1	-0.2
K content in liver	1.1	1.1	2.5	-0.2	-0.5	-0.5	0.7	0.3	-0.6	-1.4	0.8	1.5	-0.9	1.4	1.6	-1.4
Mg content in liver	1.4	1.4	2.4	0.1	-1.1	-1.1	1.1	0.7	-1.1	-1.1	1.4	1.5	-1.5	1.4	1.5	-1.1
Mn content in liver	0.4	0.4	1.1	-1.0	1.0	1.0	-0.4	-0.5	0.7	-0.6	-0.4	0.5	0.3	0.4	0.7	-0.7
Na content in liver	0.0	0.1	0.3	-0.6	-0.1	-0.1	-0.2	-0.0	-0.1	0.1	0.2	0.3	-0.2	0.1	0.3	-0.0
Rb content in liver	0.9	1.1	2.3	1.5	-1.4	-1.4	1.3	1.0	-1.4	-0.5	1.3	0.6	-1.2	0.7	0.3	-0.1
Se content in liver	0.2	0.3	1.2	-0.3	0.0	0.0	0.3	-0.1	-0.0	-0.9	0.0	0.7	-0.2	0.7	0.8	-1.1
Sr content in liver	2.5	2.3	7.8	-2.8	1.9	1.9	-1.8	-1.9	1.8	0.8	-1.5	-0.5	1.1	-0.5	0.0	0.4
Zn content in liver	0.8	0.9	5.2	-2.3	1.0	1.0	-1.1	-1.3	1.1	0.1	-0.6	0.1	0.3	-0.0	0.5	-0.2
Bone: minimum diameter	3.3	6.2	8.1	2.0	-2.8	-2.8	2.6	2.7	-2.7	-2.4	2.6	2.4	-2.5	2.3	2.0	-2.2
Time in familiar zone, hab. session 1	0.1	0.1	0.2	-0.0	-0.4	-0.4	0.2	0.2	-0.3	-0.1	0.4	0.3	-0.4	0.2	0.3	-0.3
Time in novel zone, hab. session 1	0.2	0.2	0.8	0.9	-0.2	-0.2	0.2	0.2	-0.3	0.5	0.1	-0.6	0.0	-0.5	-0.7	0.7
Total zone transitions, hab. session 1	0.6	0.8	1.7	-1.0	1.2	1.2	-1.0	-1.3	1.0	0.8	-0.8	-0.6	0.8	-0.6	-0.5	0.8
Total locomotion distance, hab. session 1	0.3	0.5	1.0	0.2	-0.5	-0.5	0.7	0.3	-0.7	-0.8	0.9	0.7	-1.0	0.8	0.8	-0.6
Locomotion velocity, hab. session 1	0.1	0.1	0.3	-0.5	0.2	0.2	0.1	-0.3	-0.0	-0.4	0.3	0.4	-0.4	0.4	0.6	-0.3
Time in familiar zone, hab. session 2	0.4	0.4	1.0	0.6	-0.1	-0.1	-0.3	0.1	0.1	1.0	-0.3	-0.8	0.4	-0.9	-1.0	0.9
Time in novel zone, hab. session 2	0.3	0.3	0.7	-0.7	0.0	0.0	0.2	-0.1	-0.2	-0.7	0.4	0.7	-0.5	0.7	0.9	-0.6
Total zone transitions, hab. session 2	0.2	0.3	1.6	-1.3	0.5	0.5	-0.6	-0.9	0.3	0.4	0.1	0.1	-0.2	-0.0	0.2	0.4
Total locomotion distance, hab. session 2	0.2	0.2	0.8	-0.3	-0.2	-0.2	0.4	-0.0	-0.5	-0.1	0.8	0.5	-0.9	0.5	0.5	-0.2
Locomotion velocity, hab. session 2	0.3	0.4	1.2	-0.1	-0.5	-0.5	0.6	0.2	-0.8	-0.4	1.0	0.7	-1.1	0.7	0.7	-0.4
Novel to familiar place preference ratio	0.4	0.5	1.4	-1.2	0.7	0.7	-0.3	-0.4	0.7	-0.8	-0.4	0.5	0.4	0.6	0.8	-0.9
Novelty place preference	0.3	0.3	0.8	-0.9	0.4	0.4	-0.2	-0.2	0.5	-0.8	-0.3	0.5	0.3	0.6	0.7	-0.9
Time in novel zone, NPP test	0.3	0.3	1.0	-1.0	0.4	0.4	-0.2	-0.3	0.5	-0.7	-0.3	0.4	0.2	0.6	0.8	-0.9
Total zone transitions, NPP test	0.7	1.0	2.8	-1.7	1.1	1.1	-1.3	-1.4	1.1	1.0	-0.8	-0.5	0.7	-0.6	-0.3	0.8
Total locomotion distance, NPP test	0.0	0.1	0.3	-0.5	0.2	0.2	-0.2	-0.3	0.0	0.3	0.2	0.0	-0.2	0.0	0.1	0.4
Locomotion velocity, NPP test	0.1	0.1	0.3	-0.4	0.4	0.4	-0.4	-0.3	0.2	0.5	-0.1	-0.2	0.2	-0.2	-0.2	0.5
Intraocular pressure	0.4	0.5	1.1	-0.1	0.4	0.4	-0.6	-0.5	0.6	0.9	-0.9	-1.0	0.8	-0.9	-0.9	0.6
Delta distance traveled before/after self-admin	0.1	0.2	0.6	0.8	-0.4	-0.4	0.4	0.5	-0.4	0.3	0.2	-0.3	-0.2	-0.1	-0.4	0.5
Delta ambulatory time before/after self-admin	0.2	0.2	0.6	0.8	-0.3	-0.3	0.2	0.4	-0.2	0.6	0.0	-0.6	0.0	-0.4	-0.7	0.8
Parametrial fat weight	3.4	6.7	9.6	2.7	-2.8	-2.8	2.9	3.1	-2.7	-2.7	2.4	2.3	-2.3	2.4	1.9	-2.4
Pavlov. Cond. lever latency	0.3	0.4	1.0	0.6	0.3	0.3	-0.2	-0.3	0.3	0.6	-0.6	-1.0	0.6	-0.7	-1.0	0.6
Pavlov. Cond. magazine entry latency	0.4	0.5	1.3	-0.5	-0.2	-0.2	0.3	0.2	-0.3	-1.0	0.5	1.1	-0.6	0.8	1.1	-1.1
Pavlov. Cond. change in total contacts	0.1	0.1	0.2	-0.2	-0.2	-0.2	0.0	0.3	-0.2	-0.3	0.3	0.5	-0.3	0.2	0.4	-0.4
Pavlov. Cond. index score	0.1	0.1	0.2	-0.5	0.1	0.1	-0.2	0.0	0.0	-0.3	0.1	0.4	-0.1	0.2	0.4	-0.3
Pavlov. Cond. latency score	0.1	0.1	0.4	-0.3	-0.2	-0.2	0.1	0.2	-0.3	-0.4	0.4	0.7	-0.4	0.4	0.6	-0.4
Pavlov. Cond. lever contacts	0.2	0.2	0.5	-0.0	-0.4	-0.4	0.3	0.5	-0.5	-0.4	0.6	0.7	-0.5	0.5	0.6	-0.4
Pavlov. Cond. magazine entry number	0.2	0.2	0.5	0.7	-0.7	-0.7	0.6	0.5	-0.5	0.0	0.4	-0.0	-0.4	0.3	-0.0	0.2
Pavlov. Cond. intertrial magazine entries	0.7	0.9	1.4	-0.5	0.9	0.9	-1.1	-0.5	0.9	1.2	-1.0	-0.9	1.0	-1.1	-0.9	1.1
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.1	0.4	-0.6	0.2	0.2	-0.3	-0.1	0.2	-0.2	-0.0	0.4	-0.0	0.1	0.4	-0.3
Pavlov. Cond. response bias	0.1	0.1	0.3	-0.5	0.2	0.2	-0.2	0.1	0.1	-0.4	0.0	0.4	-0.1	0.2	0.5	-0.6
Pavlov. Cond. lever latency	0.7	0.9	2.2	0.3	0.7	0.7	-0.7	-0.5	0.7	1.2	-0.8	-1.1	1.1	-1.0	-1.2	1.5
Pavlov. Cond. magazine entry latency	0.8	1.0	5.2	-2.3	1.0	1.0	-1.0	-1.2	0.9	-0.3	-0.6	0.2	0.2	-0.0	0.6	-1.0
Pavlov. Cond. change in total contacts	0.2	0.3	1.4	-0.9	-0.1	-0.1	-0.1	-0.2	-0.1	-0.7	0.2	0.6	-0.5	0.3	0.7	-1.2
Pavlov. Cond. index score	0.5	0.7	2.8	-1.4	0.1	0.1	-0.1	-0.2	0.1	-1.0	0.1	0.9	-0.5	0.6	1.1	-1.7
Pavlov. Cond. latency score	0.7	0.8	3.3	-1.3	-0.0	-0.0	0.1	-0.1	-0.1	-1.2	0.3	1.0	-0.7	0.8	1.3	-1.8
Pavlov. Cond. lever contacts	0.1	0.1	0.4	-0.6	-0.1	-0.1	-0.1	-0.2	-0.1	-0.1	0.1	0.2	-0.4	0.0	0.3	-0.6
Pavlov. Cond. magazine entry number	1.3	1.6	8.1	2.8	-1.3	-1.3	1.1	1.4	-1.2	0.7	0.8	-0.5	-0.2	-0.2	-1.0	1.5
Pavlov. Cond. intertrial magazine entries	0.3	0.4	1.8	1.3	-0.5	-0.5	0.3	0.9	-0.5	0.7	0.1	-0.4	0.1	-0.4	-0.7	0.9
Pavlov. Cond. lever-magazine prob. diff.	0.5	0.7	2.6	-1.6	0.2	0.2	-0.2	-0.4	0.2	-0.9	0.0	0.8	-0.4	0.5	1.1	-1.6
Pavlov. Cond. response bias	0.2	0.3	1.8	-1.3	0.2	0.2	-0.3	-0.5	0.2	-0.4	-0.1	0.4	-0.3	0.2	0.6	-1.0
Time in closed arm before self-admin	0.2	0.3	0.4	0.5	-0.6	-0.6	0.4	0.6	-0.6	-0.6	0.4	0.6	-0.4	0.4	0.4	-0.6
Time in closed arm after self-admin	0.1	0.1	0.2	0.5	-0.3	-0.3	0.4	0.3	-0.2	-0.1	0.4	0.0	-0.3	0.2	-0.0	0.1
Time in open arm before self-admin	0.4	0.4	1.9	0.5	0.1	0.1	-0.1	-0.5	0.1	1.0	-0.1	-0.9	0.3	-0.6	-0.9	1.4
Time in open arm after self-admin	1.5	1.7	2.0	-0.6	1.3	1.3	-1.3	-1.4	1.3	1.4	-1.3	-1.4	1.4	-1.4	-1.3	1.2
Bone: periosteal estimation	1.7	3.6	4.5	1.2	-1.9	-1.9	1.9	2.0	-1.9	-2.1	1.9	2.0	-1.8	1.9	1.8	-2.0
Bone: periosteal perimeter	0.9	1.4	1.9	0.8	-1.4	-1.4	1.1	1.3	-1.3	-1.2	1.3	1.3	-1.2	1.1	1.1	-1.1
Bone: post-yield work	5.7	7.7	10.6	1.9	-2.7	-2.7	2.8	2.9	-2.7	-3.3	2.8	3.0	-2.7	2.8	2.7	-2.9
Progressive ratio test 1 active lever presses	0.6	0.6	1.6	1.3	-1.1	-1.1	0.9	0.8	-1.0	-0.4	0.8	0.4	-0.7	0.4	0.1	-0.0
Progressive ratio test 1 breakpoint	0.4	0.4	1.6	1.3	-0.9	-0.9	0.7	0.6	-0.8	-0.1	0.6	0.1	-0.5	0.1	-0.1	0.2
Progressive ratio test 1 inactive lever presses	1.0	1.0	1.8	-0.1	-0.9	-0.9	1.0	0.6	-0.8	-1.3	0.9	1.2	-1.1	1.3	1.4	-1.2
Progressive ratio test 2 active lever presses	1.8	1.9	3.2	1.5	-1.8	-1.8	1.5	1.5	-1.6	-1.0	1.5	1.1	-1.4	1.0	0.8	-0.7
Progressive ratio test 2 breakpoint	1.5	1.7	3.4	1.8	-1.8	-1.8	1.4	1.5	-1.6	-0.8	1.3	0.9	-1.2	0.8	0.5	-0.4
Progressive ratio test 2 inactive lever presses	2.9	3.4	4.9	1.2	-2.2	-2.2	1.9	1.7	-2.0	-1.7	1.9	1.8	-2.0	1.8	1.6	-1.4
Incentive Sensitization - Responses	0.6	0.6	1.0	0.3	-0.8	-0.8	0.7	0.7	-0.7	-0.9	0.8	1.0	-0.8	0.9	0.9	-0.9
Incentive Sensitization - Breakpoint	1.1	1.1	1.6	0.5	-1.1	-1.1	1.0	1.0	-1.0	-1.2	1.1	1.3	-1.1	1.1	1.2	-1.1
Sum of active levers in priming session hrs 5-6	1.2	1.2	2.1	-1.1	1.1	1.1	-1.5	-1.1	1.4	0.9	-1.2	-0.9	1.2	-1.1	-0.8	0.4
Progressive ratio	0.3	0.3	0.7	0.3	-0.5	-0.5	0.6	0.1	-0.5	-0.8	0.6	0.7	-0.7	0.6	0.7	-0.6
Food seeking constrained by brief footshock	0.1	0.1	0.4	0.1	-0.2	-0.2	-0.0	-0.3	-0.1	0.5	0.1	-0.3	-0.0	-0.3	-0.4	0.6
Seeking ratio, punishment vs. effort	0.2	0.2	0.8	-0.2	0.2	0.2	-0.3	-0.1	0.2	0.9	-0.3	-0.6	0.4	-0.5	-0.6	0.8
Retroperitoneal fat weight	2.7	8.8	14.4	3.8	-3.4	-3.4	3.5	3.6	-3.2	-2.7	2.9	2.3	-2.5	2.6	1.8	-1.9
Reaction time number correct	0.3	0.5	0.8	-0.9	0.8	0.8	-0.8	-0.6	0.6	0.9	-0.5	-0.6	0.5	-0.7	-0.5	0.7
Reaction time mean minus median	0.5	0.7	1.2	-0.9	0.9	0.9	-1.1	-0.8	1.0	0.7	-1.1	-0.7	0.9	-0.9	-0.6	0.3
Reaction time mean minus median AUC	1.6	2.1	2.8	-1.0	1.4	1.4	-1.6	-1.3	1.4	1.6	-1.6	-1.6	1.5	-1.7	-1.5	1.2
Reaction time num false alarms	0.5	0.6	1.5	0.0	0.4	0.4	-0.5	-0.8	0.7	1.1	-0.7	-1.0	0.8	-0.8	-1.0	1.2
Reaction time num false alarms AUC	1.1	1.5	2.1	-0.6	1.1	1.1	-1.1	-1.3	1.3	1.5	-1.3	-1.3	1.4	-1.1	-1.2	1.4
Reaction time trials correct on left	0.3	0.5	0.8	-0.9	0.8	0.8	-0.8	-0.6	0.6	0.9	-0.5	-0.6	0.5	-0.7	-0.5	0.7
Reaction time trials on left	0.5	0.7	1.0	-1.0	0.9	0.9	-0.9	-0.7	0.8	1.0	-0.6	-0.7	0.6	-0.8	-0.6	0.9
Reaction time mean	0.1	0.2	0.5	-0.3	0.3	0.3	-0.5	-0.5	0.3	0.6	-0.4	-0.5	0.2	-0.7	-0.5	0.4
Reaction time mean AUC	0.1	0.1	0.4	-0.0	0.0	0.0	-0.3	-0.3	0.0	0.5	-0.2	-0.4	0.0	-0.6	-0.5	0.3
Median of all reaction times	0.0	0.0	0.1	-0.3	0.1	0.1	-0.2	-0.3	-0.0	0.1	-0.0	-0.0	-0.2	-0.2	-0.0	-0.1
Reaction time omissions	1.1	1.6	1.9	-0.7	1.3	1.3	-1.3	-1.3	1.3	1.3	-1.4	-1.3	1.4	-1.3	-1.2	1.1
Reaction time false alarm rate	0.1	0.2	0.4	0.2	0.2	0.2	-0.2	-0.5	0.5	0.5	-0.5	-0.6	0.7	-0.3	-0.5	0.6
Reaction time premature initiation rate	1.0	1.3	3.3	-1.4	0.5	0.5	0.2	-0.4	0.1	-1.7	0.3	1.5	-0.4	1.5	1.8	-1.7
Reaction time premature initiations	0.8	1.1	4.6	-2.2	1.4	1.4	-0.8	-1.1	1.0	-0.7	-0.4	0.6	0.4	0.5	1.0	-0.8
Std. dev. reaction times	1.0	1.5	2.2	-0.4	1.0	1.0	-1.2	-1.1	1.1	1.4	-1.3	-1.4	1.2	-1.5	-1.4	1.2
Reaction time trials completed	0.5	0.7	1.0	-1.0	0.9	0.9	-0.9	-0.7	0.8	1.0	-0.6	-0.7	0.6	-0.8	-0.6	0.9
Reaction time trials AUC	0.3	0.4	0.8	-0.8	0.7	0.7	-0.7	-0.6	0.6	0.9	-0.4	-0.5	0.4	-0.7	-0.5	0.8
Run reversals in cocaine runway, females	1.1	1.1	2.3	-0.2	-0.7	-0.7	0.9	0.8	-0.7	-1.3	0.9	1.4	-1.0	1.5	1.5	-1.2
Run reversals in cocaine runway, males	0.2	0.2	0.7	0.8	-0.0	-0.0	-0.1	0.5	0.0	0.4	-0.2	-0.4	0.5	-0.4	-0.6	0.6
Latency to leave start box in cocaine runway	2.6	2.8	4.2	1.4	-1.6	-1.6	1.8	2.0	-1.7	-1.7	1.8	1.8	-1.6	1.7	1.5	-1.5
Latency to leave start box in cocaine runway, F	0.7	0.8	1.3	0.4	-0.7	-0.7	0.8	1.0	-0.8	-1.0	0.9	1.1	-0.8	1.0	1.0	-1.0
Latency to leave start box in cocaine runway, M	1.6	1.5	4.6	2.2	-1.5	-1.5	1.5	1.7	-1.4	-0.7	1.3	0.6	-1.0	0.6	0.2	-0.4
Std. dev. time between licks in bursts	0.1	0.1	0.2	0.4	-0.3	-0.3	0.4	0.2	-0.4	0.0	0.4	0.0	-0.3	0.1	-0.1	0.3
Total sessions with >9 infusions	2.5	2.7	4.6	1.4	-2.1	-2.1	1.9	1.6	-1.9	-1.3	1.7	1.4	-1.8	1.6	1.3	-1.0
Short access day 1 total inactive lever presses	1.7	1.9	3.1	1.3	-1.8	-1.8	1.6	1.5	-1.5	-1.1	1.4	1.2	-1.5	1.3	1.1	-0.8
Short access day 10 total inactive lever presses	0.6	0.7	1.9	1.4	-1.1	-1.1	1.0	1.1	-1.0	0.0	0.8	0.1	-0.8	0.3	-0.1	0.3
Short access day 1 total infusions	1.0	1.0	1.7	1.0	-1.3	-1.3	1.2	1.0	-1.2	-0.7	1.2	0.7	-1.2	0.9	0.6	-0.4
Short access day 10 total infusions	5.4	6.0	7.8	1.2	-2.5	-2.5	2.6	2.3	-2.5	-2.5	2.6	2.7	-2.8	2.7	2.6	-2.1
Short access total infusions	2.2	2.5	3.6	0.9	-1.8	-1.8	1.8	1.3	-1.7	-1.4	1.8	1.6	-1.9	1.7	1.5	-1.1
Short access day 1 locomotion	1.0	1.0	1.7	-0.0	-0.9	-0.9	1.0	0.6	-0.8	-1.2	0.9	1.2	-1.1	1.3	1.3	-1.2
Short access day 10 total locomotion	3.6	4.0	5.2	0.5	-2.0	-2.0	2.0	1.8	-1.9	-2.1	2.0	2.2	-2.2	2.3	2.2	-2.1
Short access total locomotion	3.6	3.7	5.7	0.1	-1.8	-1.8	1.9	1.4	-1.7	-2.2	1.9	2.3	-2.1	2.4	2.4	-2.1
One hour access (0.3 mA shock)	2.7	3.1	5.5	2.3	-2.4	-2.4	2.0	2.0	-2.1	-1.0	1.8	1.1	-1.8	1.1	0.7	-0.6
Compulsive drug intake	3.0	3.0	3.7	-1.6	1.9	1.9	-1.8	-1.9	1.9	1.7	-1.7	-1.7	1.8	-1.6	-1.4	1.4
One hour access (shock baseline)	2.6	3.1	7.1	2.7	-2.3	-2.3	1.9	2.2	-2.1	-1.0	1.7	1.1	-1.7	0.9	0.5	-0.6
Social response proportion	0.0	0.0	0.1	0.1	-0.1	-0.1	0.1	-0.2	-0.1	-0.1	0.2	0.2	0.0	0.1	0.1	0.0
Social responses	0.8	1.1	1.4	-0.4	1.0	1.0	-1.1	-1.1	0.9	1.1	-0.9	-1.0	1.2	-1.1	-1.1	1.2
Social time	1.7	2.2	3.3	-0.7	1.4	1.4	-1.4	-1.6	1.3	1.8	-1.3	-1.7	1.3	-1.6	-1.6	1.7
Soleus weight	0.6	1.7	7.5	2.7	-1.6	-1.6	1.2	1.4	-1.6	0.1	1.1	-0.1	-0.8	-0.2	-0.7	0.7
Bone: stiffness	0.3	0.5	1.5	-0.3	-0.3	-0.3	0.4	0.5	-0.4	-1.0	0.5	1.0	-0.5	0.8	1.0	-1.2
Tibialis anterior weight	2.5	8.5	34.7	-5.9	3.8	3.8	-3.2	-3.6	3.5	0.6	-2.6	-0.0	2.0	-0.2	1.1	-0.4
Time to tail flick, vehicle, before self-admin	1.4	1.4	2.6	-0.1	-0.9	-0.9	1.0	0.6	-0.8	-1.5	1.0	1.5	-1.2	1.5	1.6	-1.5
Time to tail flick, vehicle, after self-admin	0.3	0.3	0.8	-0.6	0.1	0.1	0.3	-0.2	-0.2	-0.6	0.6	0.7	-0.6	0.8	0.9	-0.6
Time to tail flick, test, before self-admin	1.1	1.1	2.1	0.2	-0.8	-0.8	1.1	0.8	-0.8	-1.3	1.0	1.3	-1.0	1.5	1.4	-1.1
Time to tail flick, test, after self-admin	0.2	0.2	0.3	0.2	0.3	0.3	-0.3	-0.3	0.3	0.4	-0.4	-0.5	0.5	-0.5	-0.6	0.4
Delta time to tail flick, vehicle, before/after SA	0.2	0.2	0.3	-0.4	0.5	0.5	-0.4	-0.5	0.3	0.5	-0.2	-0.4	0.3	-0.4	-0.4	0.5
Delta time to tail flick, test, before/after SA	2.6	2.3	3.4	-0.6	1.4	1.4	-1.6	-1.5	1.5	1.6	-1.6	-1.7	1.6	-1.9	-1.7	1.3
Tibia length	0.3	0.7	2.0	-1.4	0.5	0.5	-0.4	-0.2	0.4	-1.2	-0.2	1.1	0.1	0.8	1.3	-1.4
Ambulatory time before self-admin	0.5	0.5	1.4	-1.2	0.9	0.9	-0.9	-0.8	0.8	-0.0	-0.6	-0.0	0.6	-0.3	0.1	-0.3
Ambulatory time after self-admin	0.5	0.6	1.0	0.1	-0.7	-0.7	0.6	0.8	-0.7	-0.9	0.7	1.0	-0.7	0.8	0.9	-0.9
Bone: tissue strength	0.1	0.1	0.6	0.7	-0.4	-0.4	0.3	0.3	-0.4	0.1	0.3	-0.0	-0.2	-0.1	-0.2	0.2
Total heroin consumption	4.4	5.1	8.0	-2.7	2.7	2.7	-2.7	-2.6	2.8	1.6	-2.4	-1.7	2.3	-1.8	-1.2	1.0
Bone: trabecular number	0.5	0.8	1.7	-0.3	-0.5	-0.5	0.6	0.6	-0.6	-1.2	0.7	1.2	-0.7	1.2	1.3	-1.3
Bone: trabecular spacing	1.0	1.3	3.0	-0.2	0.6	0.6	-1.0	-1.0	0.7	1.7	-0.8	-1.5	0.7	-1.5	-1.5	1.7
Bone: trabecular thickness	0.4	0.5	1.1	1.0	-0.8	-0.8	0.8	0.9	-0.8	-0.8	0.6	0.6	-0.5	0.5	0.4	-0.6
Bone: trabecular tissue density	0.5	0.7	4.1	2.0	-0.7	-0.7	0.5	0.9	-0.6	0.5	0.2	-0.7	0.0	-0.6	-1.1	0.8
Water consumed over 24 hours	0.3	0.4	0.7	-0.6	0.8	0.8	-0.6	-0.9	0.8	0.2	-0.7	-0.4	0.7	-0.4	-0.4	0.1
Number of responses in last shaping day	0.1	0.2	0.3	-0.5	0.4	0.4	-0.4	-0.6	0.4	0.4	-0.2	-0.4	0.3	-0.3	-0.3	0.4