Hub : Genes

Piwil2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	gene expression	Piwil2	0.03	0.03	5.2e-04	0.03	0.02	0.01	0.02	7.8e-04	9.4e-04	2.0e-02	1.3e-03
2	PL	gene expression	Piwil2	0.02	0.03	7.1e-03	0.02	0.02	0.02	0.01	4.1e-03	6.9e-03	6.7e-03	8.4e-03
3	NAcc	gene expression	Piwil2	0.02	0.02	9.0e-03	0.01	0.01	0	0.01	9.2e-03	1.2e-02	1.4e-01	3.7e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bone: apparent density	1.2	2.1	2.2	-1.5	-1.5	1.4
Area under the delay curve	0.1	0.1	0.1	0.4	0.2	-0.3
BMI with tail	0.4	1.5	1.5	1.2	1.2	-1.2
BMI without tail	0.0	0.0	0.0	0.1	0.1	0.1
Body weight	0.7	3.1	3.2	1.7	1.8	-1.8
Weight adjusted by age	1.6	2.4	2.6	1.5	1.6	-1.5
Bone surface	0.6	1.1	1.2	-1.1	-1.1	1.0
Bone volume	0.7	1.3	1.4	-1.1	-1.2	1.1
Breakpoint value in progressive ratio session	0.1	0.1	0.2	0.4	0.3	-0.3
Number of licking bursts	0.0	0.0	0.0	0.1	0.1	0.0
Context. condit. distance diff. score	0.9	1.1	1.1	-1.0	-1.0	1.1
Locomotion velocity, session 1	0.2	0.2	0.3	0.5	0.5	-0.4
Locomotion distance, session 1	0.0	0.0	0.0	-0.1	-0.1	0.2
Locomotion velocity, session 2	0.0	0.0	0.0	-0.1	-0.2	0.2
Locomotion distance, session 2	0.0	0.0	0.1	-0.1	-0.3	0.1
Locomotion velocity, session 3	0.5	0.6	0.7	0.8	0.7	-0.7
Locomotion distance, session 3	0.0	0.0	0.0	-0.1	-0.1	0.2
Stereotopy head waving bouts, day 3	0.7	0.8	0.9	1.0	0.8	-0.9
Stereotopy head waving duration, day 3	2.5	2.9	3.0	1.7	1.7	-1.7
Locomotion velocity, session 7	4.4	4.8	5.4	-2.1	-2.3	2.1
Locomotion distance, session 7	3.3	4.2	4.7	-2.0	-2.2	2.0
Stereotopy head waving bouts, day 7	1.4	1.6	1.9	1.3	1.2	-1.4
Stereotopy head waving duration, day 7	2.1	2.5	2.6	1.5	1.6	-1.6
Locomotion velocity, session 8	0.0	0.0	0.1	0.0	-0.3	0.0
Locomotion distance, session 8	0.7	1.0	1.1	-0.9	-1.1	1.0
Degree of sensitization distance	4.6	4.7	5.2	-2.1	-2.3	2.1
Degree of sensitization stereotypy	1.1	1.2	1.3	1.0	1.0	-1.1
Conditioned locomotion	0.0	0.0	0.0	-0.2	-0.2	0.2
Cocaine response after cond. corrected	0.2	0.2	0.3	0.5	0.4	-0.5
Cocaine response after cond. not corrected	0.1	0.1	0.2	0.4	0.3	-0.4
Cocaine response before conditioning	0.1	0.2	0.2	-0.4	-0.4	0.4
Saline control response	0.1	0.1	0.2	-0.4	-0.3	0.4
Bone: connectivity density	2.4	3.8	4.0	-2.0	-1.9	1.9
Bone: cortical apparent density	0.1	0.1	0.1	-0.3	-0.2	0.3
Bone: cortical area	0.0	0.0	0.1	-0.0	-0.3	-0.0
Bone: cortical porosity	1.2	1.3	1.3	1.1	1.1	-1.1
Bone: cortical porosity	0.7	0.7	0.7	0.9	0.8	-0.9
Bone: cortical thickness	0.0	0.0	0.1	-0.0	-0.3	0.0
Bone: cortical thickness	0.0	0.0	0.1	-0.0	-0.3	0.0
Bone: cortical tissue density	0.1	0.1	0.1	-0.3	-0.3	0.3
Condit. Reinf. active minus inactive responses	0.4	0.5	0.6	0.7	0.6	-0.7
Condit. Reinf. active-inactive response ratio	2.0	2.2	2.4	1.6	1.3	-1.5
Condit. Reinf. active responses	0.0	0.0	0.0	0.1	0.0	-0.0
Condit. Reinf. inactive responses	2.3	2.8	3.1	-1.7	-1.5	1.7
Incentive salience index mean	0.7	0.9	1.0	1.0	0.9	-0.9
Condit. Reinf. lever presses	0.3	0.4	0.4	0.7	0.6	-0.6
Condit. Reinf. active minus inactive responses	0.3	0.4	0.5	-0.7	-0.7	0.7
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.1	0.3	0.2	-0.2
Condit. Reinf. active responses	0.9	1.3	1.3	-1.1	-1.1	1.1
Condit. Reinf. inactive responses	2.0	2.5	2.6	-1.6	-1.6	1.6
Condit. Reinf. lever presses	0.1	0.2	0.2	-0.4	-0.4	0.4
Condit. Reinf. lever reinforcers received	0.7	0.9	1.0	-1.0	-1.0	1.0
Conditioned reinforcement - actives	1.0	1.7	1.7	-1.3	-1.3	1.3
Conditioned reinforcement - inactives	3.1	4.6	4.6	-2.1	-2.1	2.1
Conditioned locomotion	0.1	0.2	0.3	-0.4	-0.5	0.4
Patch foraging indifference point 0 sec	1.7	3.1	3.3	-1.8	-1.8	1.7
Patch foraging indifference point AUC	0.3	0.4	0.5	0.7	0.7	-0.5
Delay disc. indifference point, 0s delay	0.3	0.4	0.5	-0.5	-0.6	0.7
Delay disc. indifference point, 16s delay	0.2	0.2	0.3	-0.4	-0.5	0.4
Delay disc. indifference point, 2s delay	1.5	1.6	1.7	1.3	1.3	-1.3
Delay disc. indifference point, 24s delay	0.2	0.2	0.3	0.5	0.4	-0.5
Delay disc. indifference point, 4s delay	1.8	1.9	2.1	1.5	1.3	-1.3
Delay disc. indifference point, 8s delay	0.0	0.0	0.0	-0.1	-0.2	0.2
Indifference point function ln k	0.0	0.0	0.0	-0.2	-0.2	0.0
Indifference point function log k	0.0	0.0	0.0	-0.2	-0.2	0.0
Patch foraging total patch changes 0 sec	1.2	2.3	2.4	-1.6	-1.5	1.4
Patch foraging total patch changes 12 sec	0.6	0.8	0.9	-0.9	-0.8	0.9
Patch foraging total patch changes 18 sec	1.3	1.9	2.1	-1.3	-1.4	1.4
Patch foraging total patch changes 24 sec	0.0	0.0	0.0	-0.0	0.2	-0.0
Patch foraging total patch changes 6 sec	0.2	0.3	0.3	-0.5	-0.5	0.6
Patch foraging time to switch 0 sec	0.6	1.1	1.3	-1.1	-1.0	1.0
Patch foraging water rate 0 sec	0.3	0.5	0.6	0.8	0.7	-0.8
Patch foraging water rate 12 sec	0.4	0.9	1.1	1.1	0.8	-1.0
Patch foraging water rate 18 sec	2.7	4.2	4.3	2.0	2.1	-2.1
Patch foraging water rate 24 sec	0.1	0.2	0.2	0.4	0.4	-0.5
Patch foraging water rate 6 sec	2.0	2.9	3.3	1.8	1.6	-1.7
Seeking ratio, delayed vs. immediate footshock	0.8	1.0	1.1	-1.1	-1.0	1.0
Distance traveled before self-admin	0.7	0.9	1.0	0.9	1.0	-1.0
Distance traveled after self-admin	2.6	3.1	3.2	1.8	1.8	-1.8
Extensor digitorum longus weight	12.9	50.7	51.1	7.1	7.1	-7.1
Bone: elastic displacement	0.4	0.5	0.6	-0.7	-0.8	0.7
Bone: elastic work	0.3	0.3	0.5	-0.5	-0.7	0.5
Bone: endosteal estimation	0.0	0.1	0.1	0.3	0.3	-0.4
Bone: endosteal perimeter	0.0	0.1	0.1	0.2	0.2	-0.3
Epididymis fat weight	0.8	2.7	2.9	-1.7	-1.7	1.6
Delta time in closed arm before/after self-admin	4.2	3.9	4.0	-2.0	-1.9	2.0
Delta time in open arm before/after self-admin	0.1	0.1	0.2	0.4	0.3	-0.3
Diff in mean of infusions in LGA sessions	1.0	1.2	1.3	1.1	1.1	-1.1
Delay discount exponential model param	0.4	0.4	0.6	-0.7	-0.6	0.6
Extinction: sum of active levers before priming	2.1	2.3	2.5	-1.4	-1.6	1.5
Active lever presses in extinction session 6	0.6	0.6	0.7	-0.6	-0.8	0.8
Bone: final force	0.1	0.1	0.2	0.4	0.3	-0.4
Bone: final moment	0.1	0.1	0.1	0.3	0.1	-0.4
Food consumed during 24 hour testing period	0.2	0.3	0.4	-0.5	-0.7	0.6
Glucose	0.0	0.0	0.0	-0.0	-0.0	0.0
Heart weight	0.4	0.6	0.6	-0.7	-0.8	0.8
Delay discount hyperbolic model param	0.5	0.5	0.7	-0.8	-0.7	0.7
Intermittent access intake day 1-15 change	1.7	3.4	3.5	-1.9	-1.8	1.9
Intermittent access intake escalation	1.8	3.6	3.7	-1.9	-1.9	1.9
Intermittent access intake escalation 2	1.5	1.7	1.8	-1.3	-1.3	1.3
Intermitt. access day 1 inactive lever presses	0.0	0.0	0.0	-0.1	-0.1	0.1
Intermitt. access day 15 inactive lever presses	0.0	0.0	0.1	-0.2	-0.1	0.2
Intermitt. access escalation Index	0.0	0.1	0.1	0.2	0.2	-0.2
Intermittent access day 1 total infusions	0.0	0.0	0.0	0.1	0.0	-0.0
Intermittent access day 15 total infusions	1.7	2.5	2.5	-1.6	-1.6	1.6
Intermittent access terminal intake (last 3 days)	1.0	1.4	1.4	-1.2	-1.2	1.2
Intermittent access total infusions	1.2	1.4	1.6	-1.2	-1.2	1.2
Intermittent access day 1 locomotion	0.0	0.0	0.0	-0.0	-0.1	0.1
Intermittent access day 15 total locomotion	0.2	0.4	0.5	-0.6	-0.7	0.6
Intermittent access total locomotion	0.1	0.1	0.2	-0.3	-0.4	0.3
Intermittent access standard deviation	0.1	0.3	0.3	-0.5	-0.5	0.5
Left kidney weight	0.1	0.3	0.4	0.5	0.6	-0.5
Right kidney weight	0.0	0.1	0.2	0.3	0.4	-0.3
Cocaine induced anxiety	0.0	0.0	0.0	0.0	0.1	-0.0
Post-drug Anxiety	0.9	1.0	1.0	-1.0	-1.0	1.0
Baseline Anxiety	0.4	0.5	0.5	-0.7	-0.7	0.7
Tail length	0.5	1.9	2.0	-1.3	-1.3	1.4
Length with tail	0.1	0.2	0.3	0.4	0.6	-0.5
Length without tail	2.3	7.4	7.7	2.6	2.8	-2.7
Times rat made contact with spout	0.5	0.5	0.6	-0.7	-0.7	0.8
Lifetime Intake	0.7	0.9	1.0	-0.9	-1.0	0.9
Liver weight, left	1.8	3.1	3.2	1.8	1.8	-1.7
Liver weight, right	0.5	0.8	0.9	0.9	0.9	-0.9
Locomotor activity	1.8	2.8	3.0	1.6	1.7	-1.6
Locomotor testing distance	0.0	0.0	0.1	-0.1	-0.1	0.2
Locomotor testing rearing	0.1	0.2	0.3	-0.5	-0.3	0.5
Locomotion in novel chamber	0.4	0.5	0.6	-0.7	-0.7	0.8
Locomotion in novel chamber post-restriction	0.7	1.1	1.2	1.0	1.0	-1.1
Fecal boli incidents, locomotor time 1	1.0	1.4	1.5	1.1	1.2	-1.2
Change in fecal boli incidents, locomotor task	0.2	0.2	0.3	0.5	0.5	-0.5
Time >=10cm from walls, locomotor time 1	1.0	1.1	1.1	-1.0	-1.1	1.0
Bouts of movement, locomotor time 1	4.6	5.2	5.5	2.4	2.3	-2.1
Total resting periods, locomotor time 1	4.5	5.0	5.4	2.3	2.3	-2.1
Rest time, locomotor task time 1	1.8	2.2	2.4	1.5	1.5	-1.4
Distance moved, locomotor task time 1	2.1	3.2	3.6	-1.7	-1.9	1.7
Vertical activity count, locomotor time 1	0.5	1.1	1.2	-1.0	-1.1	1.0
Time >=10cm from walls, locomotor time 2	0.3	0.4	0.5	0.7	0.6	-0.6
Bouts of movement, locomotor time 2	3.2	5.1	5.4	2.3	2.3	-2.2
Total resting periods, locomotor time 2	3.2	5.6	5.8	2.4	2.4	-2.3
Rest time, locomotor task time 2	0.9	1.2	1.3	1.1	1.1	-1.0
Distance moved, locomotor task time 2	3.0	3.6	4.0	-1.8	-2.0	1.8
Vertical activity count, locomotor time 2	0.4	0.6	0.7	-0.7	-0.8	0.7
Light reinforcement 1	2.1	5.3	5.6	-2.4	-2.3	2.2
Light reinforcement 2	0.9	1.4	1.6	-1.2	-1.3	1.1
Bone: marrow area	0.0	0.0	0.1	0.2	0.2	-0.2
Bone: maximum diameter	0.3	0.5	0.7	0.8	0.6	-0.8
Bone: maximum force	0.2	0.4	0.5	0.7	0.4	-0.7
Bone: maximum moment	0.1	0.2	0.3	0.5	0.2	-0.6
Mean time between licks in bursts	1.1	2.8	3.1	-1.6	-1.8	1.6
Mean num. licks in bursts	0.3	0.4	0.4	-0.6	-0.7	0.6
Cd content in liver	1.1	1.2	1.3	1.1	1.1	-1.1
Co content in liver	5.0	5.7	5.9	2.4	2.4	-2.4
Cu content in liver	0.4	0.4	0.5	0.7	0.6	-0.6
Fe content in liver	1.6	2.0	2.0	-1.4	-1.4	1.4
K content in liver	1.2	1.1	1.2	-1.1	-1.1	1.1
Mg content in liver	2.7	2.8	2.8	-1.7	-1.7	1.7
Mn content in liver	2.5	2.8	2.8	-1.7	-1.7	1.7
Na content in liver	0.9	1.0	1.0	1.0	1.0	-1.0
Rb content in liver	0.0	0.0	0.0	-0.2	-0.2	0.2
Se content in liver	1.0	1.2	1.2	-1.1	-1.1	1.1
Sr content in liver	0.0	0.0	0.0	-0.1	-0.2	0.2
Zn content in liver	0.1	0.2	0.2	-0.4	-0.4	0.4
Bone: minimum diameter	0.1	0.2	0.3	0.5	0.3	-0.5
Time in familiar zone, hab. session 1	0.0	0.0	0.0	0.1	0.0	-0.2
Time in novel zone, hab. session 1	1.3	1.3	1.5	1.1	1.2	-1.1
Total zone transitions, hab. session 1	0.2	0.2	0.3	0.6	0.4	-0.5
Total locomotion distance, hab. session 1	0.0	0.0	0.0	0.0	-0.1	0.1
Locomotion velocity, hab. session 1	0.1	0.1	0.1	-0.3	-0.4	0.4
Time in familiar zone, hab. session 2	2.0	2.1	2.2	1.5	1.4	-1.5
Time in novel zone, hab. session 2	0.7	0.7	0.8	-0.9	-0.8	0.9
Total zone transitions, hab. session 2	1.4	1.8	1.9	1.3	1.4	-1.3
Total locomotion distance, hab. session 2	0.2	0.3	0.4	0.6	0.6	-0.5
Locomotion velocity, hab. session 2	0.6	0.8	0.8	0.9	0.9	-0.8
Novel to familiar place preference ratio	1.5	1.7	1.7	-1.3	-1.3	1.3
Novelty place preference	1.2	1.3	1.3	-1.2	-1.1	1.1
Time in novel zone, NPP test	0.6	0.7	0.7	-0.8	-0.8	0.8
Total zone transitions, NPP test	0.1	0.2	0.2	-0.4	-0.4	0.5
Total locomotion distance, NPP test	2.5	3.5	3.7	-1.9	-1.8	1.9
Locomotion velocity, NPP test	2.4	3.4	3.6	-1.8	-1.8	1.9
Intraocular pressure	0.6	0.8	0.9	-0.9	-1.0	0.8
Delta distance traveled before/after self-admin	3.2	3.4	3.8	1.9	1.8	-1.8
Delta ambulatory time before/after self-admin	2.9	3.6	3.7	1.9	1.9	-1.8
Parametrial fat weight	1.7	4.1	4.3	-2.1	-1.9	2.0
Pavlov. Cond. lever latency	0.0	0.0	0.0	-0.0	0.1	0.0
Pavlov. Cond. magazine entry latency	0.0	0.0	0.0	-0.1	-0.2	0.2
Pavlov. Cond. change in total contacts	1.1	1.2	1.3	1.2	1.0	-1.1
Pavlov. Cond. index score	0.1	0.1	0.1	0.3	0.2	-0.3
Pavlov. Cond. latency score	0.0	0.0	0.0	0.2	0.1	-0.2
Pavlov. Cond. lever contacts	0.0	0.0	0.0	-0.1	-0.2	0.1
Pavlov. Cond. magazine entry number	0.4	0.5	0.5	-0.7	-0.7	0.7
Pavlov. Cond. intertrial magazine entries	0.1	0.1	0.1	-0.4	-0.3	0.4
Pavlov. Cond. lever-magazine prob. diff.	0.2	0.2	0.3	0.5	0.4	-0.5
Pavlov. Cond. response bias	0.2	0.2	0.2	0.4	0.4	-0.4
Pavlov. Cond. lever latency	0.4	0.6	0.7	-0.8	-0.8	0.7
Pavlov. Cond. magazine entry latency	0.0	0.1	0.1	-0.2	-0.1	0.3
Pavlov. Cond. change in total contacts	1.2	2.0	2.1	1.4	1.4	-1.4
Pavlov. Cond. index score	0.5	0.6	0.7	0.8	0.9	-0.7
Pavlov. Cond. latency score	0.3	0.4	0.5	0.6	0.7	-0.6
Pavlov. Cond. lever contacts	0.2	0.3	0.4	0.6	0.6	-0.5
Pavlov. Cond. magazine entry number	0.0	0.0	0.0	0.1	-0.1	-0.2
Pavlov. Cond. intertrial magazine entries	5.2	7.9	8.0	-2.8	-2.8	2.8
Pavlov. Cond. lever-magazine prob. diff.	0.6	0.8	0.9	0.9	1.0	-0.8
Pavlov. Cond. response bias	0.3	0.4	0.4	0.6	0.6	-0.5
Time in closed arm before self-admin	1.5	1.9	2.2	1.4	1.3	-1.5
Time in closed arm after self-admin	0.0	0.0	0.0	0.1	0.1	-0.2
Time in open arm before self-admin	0.0	0.0	0.0	-0.1	0.1	0.1
Time in open arm after self-admin	0.0	0.0	0.1	-0.0	-0.1	0.2
Bone: periosteal estimation	0.0	0.1	0.1	0.2	0.1	-0.3
Bone: periosteal perimeter	0.0	0.0	0.0	0.2	0.2	-0.2
Bone: post-yield work	0.2	0.2	0.3	-0.4	-0.6	0.4
Progressive ratio test 1 active lever presses	0.1	0.1	0.1	0.4	0.3	-0.3
Progressive ratio test 1 breakpoint	0.2	0.2	0.2	0.4	0.4	-0.4
Progressive ratio test 1 inactive lever presses	0.8	1.1	1.2	-1.1	-1.0	1.1
Progressive ratio test 2 active lever presses	0.0	0.0	0.0	-0.1	-0.2	0.2
Progressive ratio test 2 breakpoint	0.0	0.0	0.0	-0.1	-0.2	0.1
Progressive ratio test 2 inactive lever presses	0.3	0.4	0.4	-0.6	-0.7	0.6
Incentive Sensitization - Responses	0.2	0.3	0.3	-0.5	-0.6	0.6
Incentive Sensitization - Breakpoint	0.3	0.4	0.5	-0.7	-0.7	0.7
Sum of active levers in priming session hrs 5-6	0.1	0.1	0.1	-0.2	-0.1	0.3
Progressive ratio	0.0	0.1	0.1	0.2	0.3	-0.1
Food seeking constrained by brief footshock	2.1	2.6	2.8	1.7	1.5	-1.6
Seeking ratio, punishment vs. effort	0.6	0.9	1.1	0.9	0.8	-1.0
Retroperitoneal fat weight	0.1	0.3	0.4	-0.6	-0.5	0.6
Reaction time number correct	0.5	0.9	1.0	1.0	0.9	-1.0
Reaction time mean minus median	0.1	0.1	0.2	0.2	0.5	-0.4
Reaction time mean minus median AUC	0.0	0.1	0.1	0.1	0.4	-0.3
Reaction time num false alarms	0.1	0.1	0.2	0.2	0.4	-0.4
Reaction time num false alarms AUC	0.1	0.1	0.1	0.1	0.3	-0.4
Reaction time trials correct on left	0.5	0.9	1.0	1.0	0.9	-1.0
Reaction time trials on left	0.4	0.7	0.8	0.9	0.8	-0.8
Reaction time mean	0.1	0.2	0.3	0.4	0.5	-0.4
Reaction time mean AUC	0.3	0.4	0.5	0.6	0.7	-0.6
Median of all reaction times	0.1	0.2	0.2	0.4	0.4	-0.4
Reaction time omissions	1.7	2.5	2.9	-1.7	-1.5	1.6
Reaction time false alarm rate	0.1	0.1	0.2	-0.4	-0.2	0.2
Reaction time premature initiation rate	1.9	2.7	3.0	1.5	1.7	-1.6
Reaction time premature initiations	2.1	3.8	4.0	1.9	2.0	-2.0
Std. dev. reaction times	0.1	0.2	0.3	0.2	0.5	-0.4
Reaction time trials completed	0.4	0.7	0.8	0.9	0.8	-0.8
Reaction time trials AUC	0.3	0.6	0.7	0.8	0.7	-0.8
Run reversals in cocaine runway, females	3.0	3.0	3.2	-1.7	-1.8	1.7
Run reversals in cocaine runway, males	1.9	1.9	2.0	1.4	1.3	-1.4
Latency to leave start box in cocaine runway	0.5	0.5	0.6	0.6	0.8	-0.8
Latency to leave start box in cocaine runway, F	1.3	1.5	1.7	1.2	1.2	-1.3
Latency to leave start box in cocaine runway, M	0.1	0.0	0.1	-0.3	-0.0	0.3
Std. dev. time between licks in bursts	1.3	1.8	1.9	-1.3	-1.4	1.3
Total sessions with >9 infusions	0.0	0.0	0.1	0.3	0.1	-0.2
Short access day 1 total inactive lever presses	0.1	0.1	0.1	-0.3	-0.3	0.4
Short access day 10 total inactive lever presses	0.1	0.2	0.2	-0.5	-0.3	0.5
Short access day 1 total infusions	0.0	0.1	0.1	0.3	0.2	-0.3
Short access day 10 total infusions	0.3	0.4	0.5	0.7	0.5	-0.6
Short access total infusions	0.0	0.0	0.1	0.3	0.1	-0.2
Short access day 1 locomotion	0.9	1.1	1.1	1.1	1.0	-1.0
Short access day 10 total locomotion	0.0	0.0	0.0	-0.0	0.2	0.1
Short access total locomotion	0.1	0.2	0.2	0.4	0.4	-0.4
One hour access (0.3 mA shock)	0.6	0.7	0.8	-0.9	-0.8	0.9
Compulsive drug intake	0.6	0.7	0.8	-0.9	-0.7	0.9
One hour access (shock baseline)	0.0	0.0	0.0	0.0	-0.0	-0.0
Social response proportion	0.1	0.1	0.1	0.3	0.2	-0.4
Social responses	1.0	1.4	1.4	-1.1	-1.2	1.2
Social time	0.3	0.4	0.4	-0.6	-0.7	0.6
Soleus weight	1.2	3.6	3.8	1.9	1.9	-1.9
Bone: stiffness	0.6	1.0	1.2	1.1	0.9	-1.1
Tibialis anterior weight	8.4	28.4	29.0	5.3	5.4	-5.3
Time to tail flick, vehicle, before self-admin	1.0	1.0	1.0	-1.0	-1.0	1.0
Time to tail flick, vehicle, after self-admin	1.3	1.8	1.9	1.4	1.3	-1.4
Time to tail flick, test, before self-admin	2.7	2.8	3.1	-1.7	-1.6	1.8
Time to tail flick, test, after self-admin	2.5	2.6	2.8	-1.7	-1.6	1.6
Delta time to tail flick, vehicle, before/after SA	0.3	0.3	0.3	0.5	0.5	-0.5
Delta time to tail flick, test, before/after SA	0.0	0.0	0.1	-0.2	-0.3	0.1
Tibia length	1.3	3.6	4.2	-1.8	-2.1	1.8
Ambulatory time before self-admin	0.2	0.3	0.3	0.5	0.6	-0.6
Ambulatory time after self-admin	5.4	6.3	6.4	2.5	2.5	-2.5
Bone: tissue strength	0.0	0.0	0.1	-0.2	-0.2	0.2
Total heroin consumption	0.6	0.7	0.8	0.9	0.8	-0.8
Bone: trabecular number	2.2	3.6	3.8	-2.0	-1.9	1.9
Bone: trabecular spacing	2.3	3.0	3.1	1.7	1.8	-1.7
Bone: trabecular thickness	1.2	1.4	1.6	-1.2	-1.3	1.2
Bone: trabecular tissue density	1.3	1.9	2.0	1.4	1.3	-1.4
Water consumed over 24 hours	1.3	1.8	1.9	1.4	1.3	-1.3
Number of responses in last shaping day	0.6	0.6	0.7	0.8	0.7	-0.8