Hub : Genes

Pcp2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Brain gene expression Pcp2 0.13 0.06 3.5e-08 0.1 0.09 0.08 0.1 9.8e-10 9.6e-09 2.7e-08 2.3e-09
2 Brain alternative TSS NM_001107116.1 0.11 0.05 3.1e-07 0.08 0.07 0.07 0.07 5.9e-08 1.6e-07 7.5e-07 5.3e-07
3 Brain alternative TSS XM_008768953.4 0.11 0.05 3.7e-07 0.08 0.07 0.06 0.07 6.2e-08 2.1e-07 2.0e-06 5.1e-07
4 Brain isoform ratio NM_001107116.1 0.11 0.06 7.5e-08 0.09 0.08 0.07 0.08 8.0e-09 3.8e-08 3.8e-07 8.0e-08
5 Brain isoform ratio XM_008768953.4 0.11 0.06 6.4e-08 0.09 0.08 0.07 0.08 7.1e-09 2.8e-08 2.5e-07 6.8e-08
6 Brain intron excision ratio chr12_6481170_6481481 0.04 0.03 4.3e-03 0.03 0.03 0.02 0.02 7.1e-04 2.2e-03 7.3e-03 3.9e-03
7 Brain intron excision ratio chr12_6481170_6481272 0.04 0.03 2.8e-03 0.03 0.02 0.02 0.02 3.8e-04 4.8e-03 3.9e-03 2.9e-03
8 Brain mRNA stability Pcp2 0.28 0.1 0.0e+00 0.24 0.3 0.3 0.3 1.1e-22 7.9e-28 8.3e-29 9.6e-29

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8
Bone: apparent density0.61.12.01.1-1.01.0-1.01.01.0-1.4-0.4
Area under the delay curve0.70.91.60.8-1.01.0-1.01.01.0-0.4-1.3
BMI with tail1.55.25.52.3-2.32.3-2.32.32.3-2.3-1.9
BMI without tail4.513.815.94.0-3.83.8-3.83.83.8-3.6-2.9
Body weight12.755.760.47.8-7.67.6-7.67.67.6-7.6-5.9
Weight adjusted by age0.10.20.30.5-0.50.5-0.50.50.5-0.50.1
Bone surface2.54.66.12.2-2.22.2-2.22.22.2-2.5-1.6
Bone volume0.71.31.91.2-1.21.2-1.21.21.2-1.4-0.7
Breakpoint value in progressive ratio session0.81.01.41.2-0.90.9-0.90.90.9-1.0-1.2
Number of licking bursts0.00.00.2-0.10.1-0.10.1-0.1-0.1-0.10.4
Context. condit. distance diff. score4.75.78.22.3-2.32.3-2.32.32.3-2.9-2.1
Locomotion velocity, session 10.10.10.2-0.20.3-0.30.3-0.3-0.3-0.2-0.5
Locomotion distance, session 10.91.11.4-1.11.2-1.21.2-1.2-1.20.70.5
Locomotion velocity, session 20.00.00.1-0.00.1-0.10.1-0.1-0.1-0.2-0.3
Locomotion distance, session 21.41.92.1-1.41.5-1.51.5-1.5-1.51.21.0
Locomotion velocity, session 30.30.40.60.6-0.60.6-0.60.60.6-0.8-0.6
Locomotion distance, session 30.70.71.1-0.80.8-0.80.8-0.8-0.80.81.1
Stereotopy head waving bouts, day 30.81.01.21.1-1.11.1-1.11.11.1-0.8-0.2
Stereotopy head waving duration, day 30.00.00.1-0.20.1-0.10.1-0.1-0.10.30.2
Locomotion velocity, session 70.70.82.00.7-0.70.7-0.70.70.7-1.0-1.4
Locomotion distance, session 70.10.20.40.4-0.40.4-0.40.40.4-0.6-0.6
Stereotopy head waving bouts, day 70.10.10.1-0.40.4-0.40.4-0.4-0.40.10.2
Stereotopy head waving duration, day 70.30.30.4-0.60.6-0.60.6-0.6-0.60.30.2
Locomotion velocity, session 80.70.91.40.9-0.80.8-0.80.80.8-1.1-1.2
Locomotion distance, session 81.72.44.01.5-1.51.5-1.51.51.5-2.0-1.6
Degree of sensitization distance0.00.00.30.0-0.00.0-0.00.00.0-0.1-0.6
Degree of sensitization stereotypy0.10.10.2-0.40.4-0.40.4-0.4-0.4-0.1-0.1
Conditioned locomotion0.30.40.9-0.60.5-0.50.5-0.5-0.50.81.0
Cocaine response after cond. corrected0.10.10.10.2-0.30.3-0.30.30.3-0.1-0.4
Cocaine response after cond. not corrected0.30.40.70.6-0.60.6-0.60.60.6-0.6-0.8
Cocaine response before conditioning0.50.60.90.8-0.70.7-0.70.70.7-0.9-0.8
Saline control response0.71.01.51.0-1.01.0-1.01.01.0-1.2-0.1
Bone: connectivity density2.74.26.52.0-2.12.1-2.12.12.1-2.5-1.3
Bone: cortical apparent density0.10.10.40.2-0.20.2-0.20.20.2-0.2-0.7
Bone: cortical area4.26.56.92.6-2.62.6-2.62.62.6-2.4-2.3
Bone: cortical porosity0.10.10.2-0.20.2-0.20.2-0.2-0.20.30.5
Bone: cortical porosity0.10.20.2-0.40.4-0.40.4-0.4-0.40.40.4
Bone: cortical thickness3.05.05.42.3-2.32.3-2.32.32.3-2.0-1.9
Bone: cortical thickness1.61.92.11.4-1.41.4-1.41.41.4-1.3-1.0
Bone: cortical tissue density0.00.00.20.1-0.00.0-0.00.00.0-0.1-0.5
Condit. Reinf. active minus inactive responses0.00.00.1-0.20.2-0.20.2-0.2-0.2-0.2-0.4
Condit. Reinf. active-inactive response ratio0.20.20.60.3-0.40.4-0.40.40.4-0.5-0.8
Condit. Reinf. active responses0.10.10.1-0.30.3-0.30.3-0.3-0.3-0.2-0.1
Condit. Reinf. inactive responses0.50.60.7-0.70.9-0.90.9-0.9-0.90.50.6
Incentive salience index mean0.10.10.2-0.40.4-0.40.4-0.4-0.40.10.0
Condit. Reinf. lever presses0.20.20.3-0.50.5-0.50.5-0.5-0.50.40.3
Condit. Reinf. active minus inactive responses3.03.94.72.0-1.91.9-1.91.91.9-2.2-2.1
Condit. Reinf. active-inactive response ratio1.72.03.01.4-1.31.3-1.31.31.3-1.6-1.7
Condit. Reinf. active responses3.34.65.02.2-2.12.1-2.12.12.1-2.2-2.1
Condit. Reinf. inactive responses0.50.60.70.8-0.80.8-0.80.80.8-0.7-0.5
Condit. Reinf. lever presses0.40.50.90.8-0.60.6-0.60.60.6-0.9-0.9
Condit. Reinf. lever reinforcers received2.53.54.01.9-1.81.8-1.81.81.8-2.0-1.9
Conditioned reinforcement - actives1.93.34.32.0-1.81.8-1.81.81.8-2.1-1.2
Conditioned reinforcement - inactives0.10.10.7-0.00.2-0.20.2-0.2-0.20.50.8
Conditioned locomotion1.82.43.11.8-1.61.6-1.61.61.6-1.6-0.9
Patch foraging indifference point 0 sec1.12.02.5-1.51.5-1.51.5-1.5-1.51.01.6
Patch foraging indifference point AUC0.30.50.70.8-0.70.7-0.70.70.7-0.8-0.2
Delay disc. indifference point, 0s delay4.95.46.42.4-2.32.3-2.32.32.3-1.9-2.5
Delay disc. indifference point, 16s delay0.20.20.30.3-0.50.5-0.50.50.5-0.2-0.6
Delay disc. indifference point, 2s delay0.70.72.10.7-0.80.8-0.80.80.8-0.3-1.5
Delay disc. indifference point, 24s delay0.00.00.2-0.10.1-0.10.1-0.1-0.10.5-0.0
Delay disc. indifference point, 4s delay0.50.51.10.6-0.70.7-0.70.70.7-0.3-1.1
Delay disc. indifference point, 8s delay0.10.10.20.3-0.40.4-0.40.40.40.1-0.4
Indifference point function ln k0.20.30.3-0.60.5-0.50.5-0.5-0.50.30.5
Indifference point function log k0.20.30.3-0.60.5-0.50.5-0.5-0.50.30.5
Patch foraging total patch changes 0 sec1.73.14.0-1.81.8-1.81.8-1.8-1.81.32.0
Patch foraging total patch changes 12 sec0.10.10.4-0.30.3-0.30.3-0.3-0.30.20.7
Patch foraging total patch changes 18 sec1.01.51.9-1.31.3-1.31.3-1.3-1.30.71.4
Patch foraging total patch changes 24 sec1.32.33.5-1.41.5-1.51.5-1.5-1.51.11.9
Patch foraging total patch changes 6 sec0.71.01.5-1.01.0-1.01.0-1.0-1.00.51.2
Patch foraging time to switch 0 sec0.10.21.00.2-0.40.4-0.40.40.40.3-1.0
Patch foraging water rate 0 sec0.10.21.4-0.20.3-0.30.3-0.3-0.3-0.31.2
Patch foraging water rate 12 sec0.10.20.5-0.40.4-0.40.4-0.4-0.40.10.7
Patch foraging water rate 18 sec0.00.00.10.00.1-0.10.1-0.1-0.10.10.3
Patch foraging water rate 24 sec0.40.50.70.6-0.80.8-0.80.80.8-0.80.1
Patch foraging water rate 6 sec0.10.10.3-0.30.3-0.30.3-0.3-0.3-0.10.6
Seeking ratio, delayed vs. immediate footshock4.04.95.6-2.42.2-2.22.2-2.2-2.22.12.0
Distance traveled before self-admin0.10.20.6-0.80.3-0.30.3-0.3-0.30.4-0.1
Distance traveled after self-admin0.10.10.1-0.30.3-0.30.3-0.3-0.30.10.2
Extensor digitorum longus weight5.019.621.94.7-4.74.7-4.74.74.7-4.2-2.9
Bone: elastic displacement0.10.10.20.3-0.30.3-0.30.30.3-0.4-0.1
Bone: elastic work2.12.73.01.7-1.71.7-1.71.71.7-1.7-0.9
Bone: endosteal estimation0.00.10.20.3-0.30.3-0.30.30.3-0.40.5
Bone: endosteal perimeter0.40.81.30.9-0.90.9-0.90.90.9-1.1-0.5
Epididymis fat weight0.00.00.10.1-0.10.1-0.10.10.1-0.2-0.3
Delta time in closed arm before/after self-admin0.60.60.60.6-0.80.8-0.80.80.8-0.7-0.8
Delta time in open arm before/after self-admin2.02.02.3-1.21.5-1.51.5-1.5-1.51.50.8
Diff in mean of infusions in LGA sessions0.20.20.60.8-0.40.4-0.40.40.4-0.5-0.4
Delay discount exponential model param0.50.61.2-0.60.8-0.80.8-0.8-0.80.21.1
Extinction: sum of active levers before priming0.10.10.30.3-0.20.2-0.20.20.2-0.1-0.6
Active lever presses in extinction session 60.00.00.10.2-0.10.1-0.10.10.1-0.10.0
Bone: final force3.35.35.92.3-2.42.4-2.42.42.4-2.2-1.8
Bone: final moment2.54.04.52.0-2.12.1-2.12.12.1-1.8-1.5
Food consumed during 24 hour testing period0.20.30.6-0.30.5-0.50.5-0.5-0.50.40.8
Glucose0.10.20.3-0.50.5-0.50.5-0.5-0.50.3-0.3
Heart weight0.20.30.50.7-0.50.5-0.50.50.5-0.6-0.2
Delay discount hyperbolic model param0.60.61.3-0.70.8-0.80.8-0.8-0.80.31.2
Intermittent access intake day 1-15 change0.10.10.30.6-0.30.3-0.30.30.3-0.30.2
Intermittent access intake escalation0.10.10.20.5-0.30.3-0.30.30.3-0.30.3
Intermittent access intake escalation 20.10.20.3-0.20.4-0.40.4-0.4-0.40.30.5
Intermitt. access day 1 inactive lever presses0.10.30.8-0.30.6-0.60.6-0.6-0.60.60.9
Intermitt. access day 15 inactive lever presses0.10.20.3-0.30.6-0.60.6-0.6-0.60.50.2
Intermitt. access escalation Index0.10.20.3-0.60.5-0.50.5-0.5-0.50.20.2
Intermittent access day 1 total infusions0.20.30.4-0.50.6-0.60.6-0.6-0.60.50.3
Intermittent access day 15 total infusions0.00.00.10.10.2-0.20.2-0.2-0.20.10.3
Intermittent access terminal intake (last 3 days)0.00.00.00.00.1-0.10.1-0.1-0.1-0.00.1
Intermittent access total infusions0.00.00.10.3-0.10.1-0.10.10.1-0.2-0.4
Intermittent access day 1 locomotion0.20.20.2-0.30.5-0.50.5-0.5-0.50.50.1
Intermittent access day 15 total locomotion0.10.10.2-0.50.3-0.30.3-0.3-0.30.20.5
Intermittent access total locomotion0.10.10.1-0.20.3-0.30.3-0.3-0.30.30.1
Intermittent access standard deviation0.10.20.4-0.10.4-0.40.4-0.4-0.40.50.6
Left kidney weight6.027.830.55.5-5.55.5-5.55.55.5-5.5-3.5
Right kidney weight5.625.427.95.3-5.25.2-5.25.25.2-5.1-3.5
Cocaine induced anxiety0.20.30.90.6-0.40.4-0.40.40.4-0.5-0.9
Post-drug Anxiety0.50.53.40.5-0.30.3-0.30.30.3-0.5-1.8
Baseline Anxiety0.10.20.6-0.20.4-0.40.4-0.4-0.40.3-0.7
Tail length8.834.239.06.2-6.16.1-6.16.16.1-5.7-4.3
Length with tail15.266.170.98.3-8.48.4-8.48.48.4-8.3-6.0
Length without tail6.922.325.14.7-4.94.9-4.94.94.9-5.0-3.3
Times rat made contact with spout1.11.31.81.2-1.11.1-1.11.11.1-1.4-1.1
Lifetime Intake0.00.00.10.00.2-0.20.2-0.2-0.2-0.0-0.2
Liver weight, left0.20.40.60.6-0.50.5-0.50.50.5-0.60.8
Liver weight, right1.11.92.21.5-1.41.4-1.41.41.4-1.5-0.9
Locomotor activity1.82.93.31.6-1.81.8-1.81.81.8-1.7-1.0
Locomotor testing distance0.10.10.20.1-0.30.3-0.30.30.3-0.50.2
Locomotor testing rearing0.51.01.5-1.21.0-1.01.0-1.0-1.00.91.1
Locomotion in novel chamber0.10.10.20.1-0.30.3-0.30.30.3-0.20.5
Locomotion in novel chamber post-restriction0.91.41.71.1-1.31.3-1.31.31.3-1.2-0.6
Fecal boli incidents, locomotor time 11.72.53.81.9-1.61.6-1.61.61.6-1.5-1.0
Change in fecal boli incidents, locomotor task0.00.00.0-0.20.2-0.20.2-0.2-0.2-0.0-0.1
Time >=10cm from walls, locomotor time 10.10.10.70.3-0.00.0-0.00.00.0-0.0-0.8
Bouts of movement, locomotor time 10.80.91.11.0-1.01.0-1.01.01.0-1.0-0.5
Total resting periods, locomotor time 11.01.11.21.1-1.11.1-1.11.11.1-1.1-0.6
Rest time, locomotor task time 11.62.03.11.7-1.41.4-1.41.41.4-1.5-1.1
Distance moved, locomotor task time 10.10.20.5-0.70.3-0.30.3-0.3-0.30.40.2
Vertical activity count, locomotor time 10.00.10.2-0.1-0.40.4-0.40.40.4-0.1-0.0
Time >=10cm from walls, locomotor time 21.92.83.81.9-1.61.6-1.61.61.6-1.6-2.0
Bouts of movement, locomotor time 20.50.91.00.8-1.01.0-1.01.01.0-0.9-0.4
Total resting periods, locomotor time 20.40.60.80.7-0.90.9-0.90.90.9-0.8-0.3
Rest time, locomotor task time 20.10.10.1-0.30.4-0.40.4-0.4-0.40.2-0.0
Distance moved, locomotor task time 20.00.00.2-0.0-0.00.0-0.00.00.00.00.4
Vertical activity count, locomotor time 20.60.81.00.9-1.01.0-1.01.01.0-0.80.1
Light reinforcement 10.10.21.10.2-0.30.3-0.30.30.3-0.4-1.0
Light reinforcement 20.30.50.8-0.50.7-0.70.7-0.7-0.70.90.7
Bone: marrow area0.00.10.30.2-0.20.2-0.20.20.2-0.30.5
Bone: maximum diameter1.32.52.81.6-1.61.6-1.61.61.6-1.7-1.1
Bone: maximum force2.03.54.01.9-2.02.0-2.02.02.0-1.7-1.2
Bone: maximum moment1.42.52.91.7-1.71.7-1.71.71.7-1.4-1.0
Mean time between licks in bursts1.23.03.1-1.71.8-1.81.8-1.8-1.81.71.6
Mean num. licks in bursts0.10.20.40.5-0.50.5-0.50.50.5-0.4-0.6
Cd content in liver0.00.00.1-0.00.0-0.00.0-0.0-0.00.20.3
Co content in liver1.21.43.8-1.11.0-1.01.0-1.0-1.01.11.9
Cu content in liver0.30.40.6-0.60.8-0.80.8-0.8-0.8-0.00.3
Fe content in liver0.50.60.80.8-0.80.8-0.80.80.8-0.9-0.9
K content in liver0.30.20.70.4-0.40.4-0.40.40.4-0.6-0.8
Mg content in liver0.40.40.80.7-0.60.6-0.60.60.6-0.9-0.8
Mn content in liver0.30.40.4-0.60.6-0.60.6-0.6-0.60.50.5
Na content in liver1.21.32.51.1-1.01.0-1.01.01.0-1.6-1.2
Rb content in liver1.92.22.6-1.51.6-1.61.6-1.6-1.61.50.7
Se content in liver4.14.87.22.1-2.12.1-2.12.12.1-2.3-2.7
Sr content in liver0.10.10.5-0.20.2-0.20.2-0.2-0.20.30.7
Zn content in liver0.50.51.20.8-0.70.7-0.70.70.7-1.1-0.1
Bone: minimum diameter0.00.00.1-0.20.1-0.10.1-0.1-0.10.00.2
Time in familiar zone, hab. session 11.51.41.8-1.11.1-1.11.1-1.1-1.11.31.3
Time in novel zone, hab. session 11.41.41.91.2-1.11.1-1.11.11.1-1.4-1.3
Total zone transitions, hab. session 10.40.50.6-0.80.8-0.80.8-0.8-0.80.60.2
Total locomotion distance, hab. session 10.00.00.1-0.20.1-0.10.1-0.1-0.10.0-0.4
Locomotion velocity, hab. session 10.10.20.3-0.50.5-0.50.5-0.5-0.50.4-0.2
Time in familiar zone, hab. session 20.00.00.10.1-0.10.1-0.10.10.10.3-0.0
Time in novel zone, hab. session 20.10.10.1-0.30.3-0.30.3-0.3-0.3-0.10.0
Total zone transitions, hab. session 20.10.10.20.3-0.30.3-0.30.30.3-0.4-0.1
Total locomotion distance, hab. session 20.00.10.1-0.30.2-0.20.2-0.2-0.20.30.2
Locomotion velocity, hab. session 20.10.10.1-0.30.3-0.30.3-0.3-0.30.30.3
Novel to familiar place preference ratio0.00.00.10.1-0.10.1-0.10.10.1-0.3-0.2
Novelty place preference0.00.00.0-0.20.2-0.20.2-0.2-0.2-0.0-0.0
Time in novel zone, NPP test0.00.00.1-0.0-0.00.0-0.00.00.0-0.2-0.2
Total zone transitions, NPP test0.10.10.40.3-0.20.2-0.20.20.2-0.6-0.4
Total locomotion distance, NPP test0.30.41.10.5-0.50.5-0.50.50.5-0.9-1.0
Locomotion velocity, NPP test0.30.40.70.5-0.50.5-0.50.50.5-0.8-0.9
Intraocular pressure0.30.50.70.5-0.80.8-0.80.80.8-0.5-0.1
Delta distance traveled before/after self-admin0.10.10.40.10.2-0.20.2-0.2-0.20.00.6
Delta ambulatory time before/after self-admin0.60.71.1-0.60.9-0.90.9-0.9-0.90.71.0
Parametrial fat weight0.30.60.70.8-0.80.8-0.80.80.8-0.7-0.8
Pavlov. Cond. lever latency1.01.31.41.1-1.21.2-1.21.21.2-1.1-0.8
Pavlov. Cond. magazine entry latency0.70.91.01.0-1.01.0-1.01.01.0-0.8-0.5
Pavlov. Cond. change in total contacts0.40.40.80.7-0.60.6-0.60.60.6-0.5-0.9
Pavlov. Cond. index score0.10.10.10.3-0.30.3-0.30.30.3-0.3-0.2
Pavlov. Cond. latency score0.00.00.00.2-0.10.1-0.10.10.1-0.1-0.2
Pavlov. Cond. lever contacts0.50.60.7-0.80.8-0.80.8-0.8-0.80.80.5
Pavlov. Cond. magazine entry number0.60.80.9-1.01.0-1.01.0-1.0-1.00.90.6
Pavlov. Cond. intertrial magazine entries1.31.61.9-1.41.3-1.31.3-1.3-1.30.90.9
Pavlov. Cond. lever-magazine prob. diff.0.10.10.10.4-0.30.3-0.30.30.3-0.2-0.3
Pavlov. Cond. response bias0.30.40.40.7-0.60.6-0.60.60.6-0.6-0.4
Pavlov. Cond. lever latency0.30.41.2-0.60.5-0.50.5-0.5-0.50.81.1
Pavlov. Cond. magazine entry latency0.10.10.70.2-0.10.1-0.10.10.1-0.1-0.9
Pavlov. Cond. change in total contacts0.00.10.30.2-0.10.1-0.10.10.1-0.4-0.5
Pavlov. Cond. index score0.00.10.50.2-0.00.0-0.00.00.0-0.2-0.7
Pavlov. Cond. latency score0.10.10.50.2-0.10.1-0.10.10.1-0.2-0.7
Pavlov. Cond. lever contacts0.30.51.40.7-0.50.5-0.50.50.5-0.8-1.2
Pavlov. Cond. magazine entry number0.10.10.20.1-0.30.3-0.30.30.3-0.20.4
Pavlov. Cond. intertrial magazine entries0.20.30.50.5-0.60.6-0.60.60.6-0.7-0.1
Pavlov. Cond. lever-magazine prob. diff.0.10.10.50.2-0.00.0-0.00.00.0-0.2-0.7
Pavlov. Cond. response bias0.20.21.10.4-0.30.3-0.30.30.3-0.5-1.1
Time in closed arm before self-admin0.60.80.90.9-0.90.9-0.90.90.9-0.9-0.1
Time in closed arm after self-admin0.80.81.00.8-1.01.0-1.01.01.0-0.9-0.2
Time in open arm before self-admin0.10.10.10.2-0.30.3-0.30.30.3-0.2-0.4
Time in open arm after self-admin0.30.40.4-0.50.7-0.70.7-0.7-0.70.60.0
Bone: periosteal estimation1.42.93.31.8-1.81.8-1.81.81.8-1.7-1.1
Bone: periosteal perimeter1.32.22.51.5-1.51.5-1.51.51.5-1.6-1.4
Bone: post-yield work0.00.00.00.1-0.20.2-0.20.20.2-0.10.1
Progressive ratio test 1 active lever presses0.81.01.21.1-1.01.0-1.01.01.0-1.1-0.7
Progressive ratio test 1 breakpoint0.91.11.31.1-1.01.0-1.01.01.0-1.1-0.7
Progressive ratio test 1 inactive lever presses0.10.10.7-0.10.2-0.20.2-0.2-0.20.30.8
Progressive ratio test 2 active lever presses0.30.40.40.6-0.60.6-0.60.60.6-0.6-0.2
Progressive ratio test 2 breakpoint0.20.30.30.5-0.60.6-0.60.60.6-0.6-0.1
Progressive ratio test 2 inactive lever presses0.10.20.30.5-0.40.4-0.40.40.4-0.40.6
Incentive Sensitization - Responses0.00.10.1-0.30.3-0.30.3-0.3-0.30.20.2
Incentive Sensitization - Breakpoint0.10.10.2-0.40.4-0.40.4-0.4-0.40.30.3
Sum of active levers in priming session hrs 5-60.50.50.90.8-0.60.6-0.60.60.6-0.6-0.9
Progressive ratio0.50.91.2-0.80.9-0.90.9-0.9-0.91.10.9
Food seeking constrained by brief footshock4.55.55.8-2.32.4-2.42.4-2.4-2.42.42.3
Seeking ratio, punishment vs. effort0.10.10.20.2-0.30.3-0.30.30.3-0.5-0.2
Retroperitoneal fat weight0.31.43.70.9-1.01.0-1.01.01.0-1.3-1.9
Reaction time number correct0.10.20.5-0.40.5-0.50.5-0.5-0.5-0.00.7
Reaction time mean minus median1.94.66.02.3-2.12.1-2.12.12.1-2.1-2.5
Reaction time mean minus median AUC0.10.30.60.7-0.40.4-0.40.40.4-0.4-0.8
Reaction time num false alarms0.10.10.20.3-0.30.3-0.30.30.3-0.2-0.5
Reaction time num false alarms AUC0.00.10.10.2-0.30.3-0.30.30.3-0.0-0.2
Reaction time trials correct on left0.10.20.5-0.40.5-0.50.5-0.5-0.5-0.00.7
Reaction time trials on left0.10.20.4-0.40.5-0.50.5-0.5-0.5-0.10.6
Reaction time mean0.10.10.80.0-0.10.1-0.10.10.10.3-0.9
Reaction time mean AUC0.10.10.5-0.10.1-0.10.1-0.1-0.10.4-0.7
Median of all reaction times0.40.51.2-0.80.7-0.70.7-0.7-0.71.1-0.2
Reaction time omissions0.10.10.40.3-0.10.1-0.10.10.1-0.2-0.6
Reaction time false alarm rate0.20.30.40.5-0.60.6-0.60.60.6-0.1-0.6
Reaction time premature initiation rate0.50.71.01.0-0.90.9-0.90.90.9-0.5-0.6
Reaction time premature initiations0.10.20.40.6-0.50.5-0.50.50.5-0.4-0.2
Std. dev. reaction times0.71.32.61.2-1.11.1-1.11.11.1-0.9-1.6
Reaction time trials completed0.10.20.4-0.40.5-0.50.5-0.5-0.5-0.10.6
Reaction time trials AUC0.20.40.6-0.50.6-0.60.6-0.6-0.60.10.8
Run reversals in cocaine runway, females0.90.91.1-0.91.0-1.01.0-1.0-1.00.90.6
Run reversals in cocaine runway, males0.90.91.3-0.90.9-0.90.9-0.9-0.90.91.1
Latency to leave start box in cocaine runway0.10.10.40.4-0.30.3-0.30.30.3-0.4-0.6
Latency to leave start box in cocaine runway, F0.40.50.50.7-0.70.7-0.70.70.7-0.7-0.7
Latency to leave start box in cocaine runway, M0.10.10.1-0.30.4-0.40.4-0.4-0.40.30.1
Std. dev. time between licks in bursts0.10.10.10.3-0.30.3-0.30.30.3-0.10.2
Total sessions with >9 infusions0.10.20.2-0.30.5-0.50.5-0.5-0.50.30.2
Short access day 1 total inactive lever presses0.10.20.4-0.30.3-0.30.3-0.3-0.30.50.6
Short access day 10 total inactive lever presses0.00.10.30.3-0.20.2-0.20.20.20.10.5
Short access day 1 total infusions0.91.21.4-1.01.2-1.21.2-1.2-1.21.10.7
Short access day 10 total infusions0.30.30.4-0.60.7-0.70.7-0.7-0.70.30.3
Short access total infusions0.20.30.4-0.40.6-0.60.6-0.6-0.60.50.1
Short access day 1 locomotion0.00.00.10.1-0.10.1-0.10.10.1-0.1-0.4
Short access day 10 total locomotion0.50.81.3-0.90.9-0.90.9-0.9-0.90.91.1
Short access total locomotion0.10.20.2-0.40.4-0.40.4-0.4-0.40.40.1
One hour access (0.3 mA shock)0.10.20.9-0.10.2-0.20.2-0.2-0.20.10.9
Compulsive drug intake2.32.73.2-1.81.7-1.71.7-1.7-1.71.71.3
One hour access (shock baseline)0.91.41.91.3-1.21.2-1.21.21.2-1.4-0.7
Social response proportion8.910.111.53.4-3.23.2-3.23.23.2-3.2-2.6
Social responses1.82.43.31.8-1.61.6-1.61.61.6-1.5-0.8
Social time0.50.61.1-0.80.8-0.80.8-0.8-0.81.10.5
Soleus weight0.72.02.41.5-1.51.5-1.51.51.5-1.4-0.6
Bone: stiffness1.21.92.01.4-1.41.4-1.41.41.4-1.3-1.2
Tibialis anterior weight7.926.929.05.4-5.45.4-5.45.45.4-5.1-3.9
Time to tail flick, vehicle, before self-admin0.60.61.70.7-0.70.7-0.70.70.7-0.6-1.3
Time to tail flick, vehicle, after self-admin0.20.20.40.3-0.50.5-0.50.50.5-0.6-0.6
Time to tail flick, test, before self-admin1.01.01.61.1-1.01.0-1.01.01.0-1.3-0.6
Time to tail flick, test, after self-admin0.10.10.30.1-0.30.3-0.30.30.3-0.2-0.6
Delta time to tail flick, vehicle, before/after SA0.20.20.3-0.60.5-0.50.5-0.5-0.50.30.5
Delta time to tail flick, test, before/after SA1.01.01.6-1.31.0-1.01.0-1.0-1.01.30.7
Tibia length3.910.712.43.5-3.53.5-3.53.53.5-2.8-2.2
Ambulatory time before self-admin0.00.00.1-0.3-0.10.1-0.10.10.10.0-0.4
Ambulatory time after self-admin0.10.20.2-0.50.4-0.40.4-0.4-0.40.30.2
Bone: tissue strength1.01.01.3-1.01.0-1.01.0-1.0-1.01.01.1
Total heroin consumption0.60.70.9-0.80.9-0.90.9-0.9-0.90.8-0.0
Bone: trabecular number1.62.64.31.5-1.61.6-1.61.61.6-2.1-1.1
Bone: trabecular spacing2.63.54.7-1.81.9-1.91.9-1.9-1.92.21.6
Bone: trabecular thickness2.73.43.91.9-1.91.9-1.91.91.9-2.0-1.4
Bone: trabecular tissue density3.65.46.62.4-2.32.3-2.32.32.3-2.0-2.6
Water consumed over 24 hours0.50.71.31.0-0.80.8-0.80.80.8-1.1-0.4
Number of responses in last shaping day0.30.30.4-0.30.6-0.60.6-0.6-0.60.40.2