Hub : Genes

Pcp2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Eye gene expression Pcp2 0.48 0.18 2.3e-03 0.07 0.07 0.05 0.09 3.6e-02 2.9e-02 5.3e-02 1.9e-02
2 Brain alternative TSS XM_008768953.3 0.13 0.06 3.1e-08 0.09 0.09 0.08 0.09 5.8e-09 5.9e-09 7.1e-08 4.8e-09
3 Brain gene expression Pcp2 0.11 0.06 8.8e-07 0.08 0.07 0.07 0.08 3.0e-08 2.4e-07 1.6e-07 5.4e-08
4 Brain isoform ratio XM_008768953.3 0.13 0.06 2.0e-08 0.1 0.1 0.09 0.1 4.0e-09 2.3e-09 1.0e-08 3.1e-09
5 Brain mRNA stability Pcp2 0.31 0.11 0.0e+00 0.21 0.29 0.28 0.29 1.2e-19 4.8e-27 1.5e-26 3.0e-27
6 Brain intron excision ratio chr12_1683275_1683586 0.05 0.03 2.3e-03 0.02 0.03 0.02 0.02 2.3e-03 1.0e-03 5.3e-03 3.5e-03
7 Brain intron excision ratio chr12_1683275_1683377 0.04 0.03 4.3e-03 0.04 0.04 0.06 0.04 1.1e-04 2.4e-04 2.4e-06 1.4e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7
Bone: apparent density0.81.45.32.31.4-1.40.2-0.2-0.1-0.3
Area under the delay curve1.01.02.7-0.90.7-0.91.1-1.61.00.4
BMI with tail2.37.411.12.93.3-3.32.4-3.32.10.7
BMI without tail3.67.411.22.63.2-3.32.9-2.72.80.2
Body weight10.443.565.78.08.1-7.96.2-6.15.91.8
Weight adjusted by age0.20.21.31.10.2-0.2-0.10.3-0.1-0.0
Bone surface2.13.79.23.02.4-2.61.2-1.40.9-0.0
Bone volume0.81.45.12.31.4-1.50.1-0.5-0.2-0.3
Breakpoint value in progressive ratio session1.11.22.3-0.21.3-1.31.2-1.50.9-0.4
Number of licking bursts0.60.71.61.30.00.10.50.81.01.2
Context. condit. distance diff. score2.53.06.30.72.5-2.31.8-1.91.5-0.4
Locomotion velocity, session 10.10.10.7-0.9-0.10.00.1-0.30.1-0.2
Locomotion distance, session 10.60.82.3-1.5-1.00.9-0.60.6-0.6-0.4
Locomotion velocity, session 20.10.10.4-0.4-0.1-0.10.5-0.30.60.2
Locomotion distance, session 21.11.53.9-2.0-1.51.2-0.81.2-0.6-1.0
Locomotion velocity, session 30.30.30.80.20.6-0.90.5-0.50.3-0.7
Locomotion distance, session 30.50.61.1-0.5-0.70.6-0.81.0-0.8-0.6
Stereotopy head waving bouts, day 30.70.82.61.61.0-1.00.6-0.40.60.3
Stereotopy head waving duration, day 30.10.10.30.60.00.0-0.1-0.1-0.10.4
Locomotion velocity, session 70.91.01.8-0.10.9-1.01.2-1.31.20.5
Locomotion distance, session 70.40.51.0-1.00.6-0.50.8-0.50.8-0.5
Stereotopy head waving bouts, day 70.50.61.5-1.2-0.80.7-0.60.4-0.6-0.6
Stereotopy head waving duration, day 70.30.30.7-0.9-0.70.7-0.50.3-0.5-0.1
Locomotion velocity, session 80.80.91.40.60.9-1.21.1-1.11.10.2
Locomotion distance, session 81.01.52.50.51.6-1.61.4-1.31.2-0.2
Degree of sensitization distance0.30.31.1-1.10.10.10.6-0.50.70.3
Degree of sensitization stereotypy0.20.20.6-0.8-0.40.3-0.20.0-0.3-0.5
Conditioned locomotion0.50.51.3-0.1-0.60.7-1.00.6-1.2-0.4
Cocaine response after cond. corrected0.50.62.71.70.2-0.3-0.0-0.7-0.10.8
Cocaine response after cond. not corrected0.50.51.51.20.6-0.70.2-1.1-0.00.3
Cocaine response before conditioning0.60.71.7-1.20.7-0.90.4-0.60.0-1.3
Saline control response0.40.51.00.60.8-0.70.80.31.0-0.3
Bone: connectivity density2.03.27.52.72.3-2.41.2-1.01.1-0.1
Bone: cortical apparent density0.10.20.4-0.30.1-0.30.5-0.60.40.3
Bone: cortical area2.53.86.61.62.5-2.62.0-2.11.80.1
Bone: cortical porosity0.00.00.10.2-0.00.1-0.10.2-0.10.3
Bone: cortical porosity0.20.20.7-0.8-0.30.4-0.30.4-0.3-0.1
Bone: cortical thickness2.23.65.91.82.3-2.41.9-1.91.80.1
Bone: cortical thickness1.01.22.00.81.3-1.41.3-0.61.3-0.3
Bone: cortical tissue density0.10.10.2-0.3-0.0-0.10.3-0.40.30.3
Condit. Reinf. active minus inactive responses0.10.10.4-0.7-0.20.2-0.2-0.3-0.3-0.2
Condit. Reinf. active-inactive response ratio0.20.20.8-0.20.4-0.40.3-0.90.10.0
Condit. Reinf. active responses0.30.31.5-1.2-0.30.3-0.3-0.0-0.4-0.6
Condit. Reinf. inactive responses0.81.03.4-1.8-0.80.7-0.60.7-0.6-0.9
Incentive salience index mean0.40.41.4-1.2-0.50.3-0.50.1-0.7-0.8
Condit. Reinf. lever presses0.50.72.0-1.4-0.50.3-0.60.4-0.8-1.2
Condit. Reinf. active minus inactive responses2.73.35.30.42.1-2.12.3-1.92.30.3
Condit. Reinf. active-inactive response ratio2.12.24.20.11.6-1.62.0-1.62.10.5
Condit. Reinf. active responses2.43.35.20.22.3-2.22.2-1.92.0-0.3
Condit. Reinf. inactive responses0.20.30.7-0.10.7-0.60.3-0.40.1-0.9
Condit. Reinf. lever presses0.30.40.8-0.50.9-0.80.5-0.70.2-0.5
Condit. Reinf. lever reinforcers received1.92.74.1-0.22.0-2.02.0-1.81.9-0.3
Conditioned reinforcement - actives2.82.84.61.42.0-1.91.9-0.92.1-0.9
Conditioned reinforcement - inactives0.20.20.70.5-0.40.3-0.20.8-0.0-0.5
Conditioned locomotion1.21.52.40.71.5-1.41.2-0.51.2-1.5
Patch foraging indifference point 0 sec1.21.93.5-0.1-1.31.4-1.81.9-1.8-0.6
Patch foraging indifference point AUC0.20.30.40.50.6-0.60.5-0.20.6-0.4
Delay disc. indifference point, 0s delay3.74.17.11.61.8-2.22.1-2.72.01.3
Delay disc. indifference point, 16s delay0.30.30.7-0.70.2-0.40.6-0.80.60.3
Delay disc. indifference point, 2s delay0.80.93.3-1.20.5-0.70.7-1.80.3-0.1
Delay disc. indifference point, 24s delay0.20.20.6-0.8-0.30.10.3-0.30.40.7
Delay disc. indifference point, 4s delay0.40.41.6-0.80.3-0.60.5-1.30.30.1
Delay disc. indifference point, 8s delay0.30.31.4-1.20.1-0.40.4-0.60.4-0.4
Indifference point function ln k0.20.31.0-0.6-0.60.5-0.51.0-0.4-0.1
Indifference point function log k0.20.31.0-0.6-0.60.5-0.51.0-0.4-0.1
Patch foraging total patch changes 0 sec1.82.95.1-0.4-1.71.7-2.12.3-2.1-0.8
Patch foraging total patch changes 12 sec0.30.40.90.3-0.30.4-0.90.7-1.0-0.4
Patch foraging total patch changes 18 sec1.21.53.10.2-1.11.2-1.51.8-1.4-0.5
Patch foraging total patch changes 24 sec2.22.74.5-1.4-1.41.5-1.62.1-1.7-1.7
Patch foraging total patch changes 6 sec0.71.11.9-0.0-0.80.9-1.31.4-1.4-0.7
Patch foraging time to switch 0 sec0.50.82.31.00.1-0.10.1-1.5-0.01.5
Patch foraging water rate 0 sec0.50.83.3-0.1-0.10.1-0.51.8-0.4-1.3
Patch foraging water rate 12 sec0.50.71.6-1.1-0.50.4-0.41.2-0.4-1.3
Patch foraging water rate 18 sec0.60.83.1-1.8-0.30.20.00.60.0-1.3
Patch foraging water rate 24 sec0.20.31.00.00.6-0.50.40.50.5-1.0
Patch foraging water rate 6 sec0.60.92.9-0.9-0.30.3-0.61.1-0.8-1.7
Seeking ratio, delayed vs. immediate footshock2.42.75.0-0.6-2.22.2-1.81.9-1.5-0.2
Distance traveled before self-admin0.20.21.1-1.0-0.10.20.2-0.30.2-0.3
Distance traveled after self-admin0.40.52.7-0.60.2-0.10.3-0.20.3-1.6
Extensor digitorum longus weight3.011.721.23.44.5-4.63.3-2.93.0-0.4
Bone: elastic displacement0.10.10.40.60.5-0.40.3-0.00.30.0
Bone: elastic work1.21.63.01.71.7-1.61.1-0.71.10.1
Bone: endosteal estimation0.10.10.50.70.3-0.2-0.10.60.0-0.2
Bone: endosteal perimeter0.10.30.80.10.9-0.80.4-0.10.2-0.7
Epididymis fat weight0.10.30.8-0.40.6-0.40.1-0.9-0.2-0.8
Delta time in closed arm before/after self-admin1.81.710.9-0.60.3-0.20.6-0.10.6-3.3
Delta time in open arm before/after self-admin6.56.335.1-1.0-1.31.3-1.30.5-1.55.9
Diff in mean of infusions in LGA sessions0.20.20.8-0.50.2-0.2-0.0-0.1-0.2-0.9
Delay discount exponential model param0.90.92.31.3-0.50.8-1.01.5-0.8-0.2
Extinction: sum of active levers before priming0.30.21.1-1.0-0.30.3-0.3-0.2-0.4-0.4
Active lever presses in extinction session 60.10.10.20.20.4-0.40.1-0.30.0-0.4
Bone: final force2.54.15.72.02.4-2.42.2-1.72.20.8
Bone: final moment2.03.34.61.92.1-2.11.9-1.42.00.8
Food consumed during 24 hour testing period0.20.20.80.7-0.30.3-0.30.9-0.20.0
Glucose0.10.20.5-0.10.2-0.10.4-0.70.50.6
Heart weight0.50.62.3-1.5-0.30.30.40.70.6-1.0
Delay discount hyperbolic model param0.80.82.21.2-0.50.7-0.91.5-0.7-0.4
Intermittent access intake day 1-15 change0.40.41.31.00.1-0.20.10.60.3-1.1
Intermittent access intake escalation0.40.41.90.70.3-0.40.20.40.4-1.4
Intermittent access intake escalation 20.40.41.4-0.1-0.50.4-0.40.8-0.3-1.2
Intermitt. access day 1 inactive lever presses0.50.62.0-0.0-0.90.8-0.61.4-0.40.3
Intermitt. access day 15 inactive lever presses0.50.51.31.1-0.70.6-0.80.3-0.80.1
Intermitt. access escalation Index0.80.71.9-1.4-0.50.6-0.40.6-0.5-1.2
Intermittent access day 1 total infusions0.60.72.9-1.7-0.50.5-0.20.2-0.3-1.2
Intermittent access day 15 total infusions0.60.73.7-0.8-0.40.3-0.20.6-0.2-1.9
Intermittent access terminal intake (last 3 days)0.40.41.4-0.8-0.60.5-0.40.5-0.4-1.2
Intermittent access total infusions0.40.51.8-1.1-0.30.3-0.1-0.0-0.2-1.3
Intermittent access day 1 locomotion1.51.65.1-2.2-0.90.9-0.70.3-1.0-1.6
Intermittent access day 15 total locomotion0.90.93.4-1.6-0.40.3-0.10.6-0.2-1.8
Intermittent access total locomotion1.51.75.2-2.3-0.70.7-0.40.4-0.6-2.3
Intermittent access standard deviation0.50.51.61.3-0.40.4-0.70.6-0.60.6
Left kidney weight5.114.421.94.54.7-4.63.8-2.73.90.6
Right kidney weight4.612.920.44.54.4-4.33.5-2.73.51.1
Cocaine induced anxiety0.60.73.0-1.2-0.20.2-0.4-0.1-0.7-1.7
Post-drug Anxiety0.60.72.7-1.7-0.50.5-0.3-0.6-0.5-0.8
Baseline Anxiety0.40.41.7-0.5-0.50.5-0.1-0.6-0.11.3
Tail length5.617.025.44.25.0-5.04.4-3.44.40.2
Length with tail10.438.058.17.17.6-7.46.2-5.06.11.3
Length without tail6.614.523.94.64.9-4.53.4-3.63.11.4
Times rat made contact with spout1.01.22.00.91.3-1.11.3-0.81.40.3
Lifetime Intake0.20.20.6-0.7-0.20.2-0.1-0.2-0.2-0.8
Liver weight, left0.30.51.51.2-0.20.4-0.71.0-0.60.3
Liver weight, right1.01.63.01.71.7-1.61.0-0.80.9-0.2
Locomotor activity1.52.33.80.21.8-1.91.9-1.02.0-1.1
Locomotor testing distance0.10.20.50.30.3-0.30.20.30.3-0.7
Locomotor testing rearing0.61.01.6-0.5-1.01.0-1.21.1-1.3-0.4
Locomotion in novel chamber0.20.31.2-0.4-0.20.20.10.80.2-1.1
Locomotion in novel chamber post-restriction1.01.22.10.21.4-1.51.3-0.51.30.4
Fecal boli incidents, locomotor time 10.60.71.50.31.2-1.00.9-0.50.90.6
Change in fecal boli incidents, locomotor task0.30.30.40.5-0.60.6-0.50.2-0.40.5
Time >=10cm from walls, locomotor time 10.30.30.7-0.8-0.20.1-0.2-0.9-0.50.6
Bouts of movement, locomotor time 10.60.71.00.71.0-1.00.9-0.40.9-0.6
Total resting periods, locomotor time 10.60.71.10.51.0-1.00.9-0.50.9-0.5
Rest time, locomotor task time 10.40.50.90.71.0-0.90.6-0.60.6-0.3
Distance moved, locomotor task time 10.10.20.8-0.9-0.30.3-0.00.10.00.3
Vertical activity count, locomotor time 10.10.10.3-0.50.3-0.20.5-0.00.6-0.3
Time >=10cm from walls, locomotor time 21.71.83.51.11.5-1.61.1-1.90.81.2
Bouts of movement, locomotor time 20.50.61.30.41.0-1.00.6-0.40.5-1.1
Total resting periods, locomotor time 20.40.51.20.50.8-0.80.4-0.30.3-1.1
Rest time, locomotor task time 20.30.31.0-0.6-0.30.3-0.50.1-0.6-1.0
Distance moved, locomotor task time 20.30.41.70.60.1-0.00.30.30.61.3
Vertical activity count, locomotor time 20.80.81.71.20.8-0.81.00.11.30.6
Light reinforcement 10.30.51.1-1.10.3-0.40.7-1.10.6-0.2
Light reinforcement 20.20.30.6-0.2-0.80.7-0.50.7-0.30.3
Bone: marrow area0.10.20.50.70.2-0.1-0.10.7-0.0-0.2
Bone: maximum diameter0.71.42.51.51.6-1.51.0-0.90.8-0.1
Bone: maximum force1.32.23.71.61.9-1.91.5-1.11.50.2
Bone: maximum moment0.91.62.71.51.6-1.61.2-0.81.20.2
Mean time between licks in bursts1.42.03.0-1.4-1.71.7-1.51.3-1.5-0.5
Mean num. licks in bursts0.20.20.6-0.40.5-0.40.1-0.7-0.2-0.8
Cd content in liver3.43.75.3-2.3-2.22.2-1.72.3-1.5-0.9
Co content in liver0.50.62.00.4-0.80.7-0.91.4-0.60.0
Cu content in liver0.91.01.5-0.9-0.81.0-1.11.1-1.2-0.9
Fe content in liver0.91.02.3-0.01.4-1.30.8-0.70.4-1.5
K content in liver0.10.10.20.20.3-0.30.0-0.4-0.1-0.3
Mg content in liver0.40.40.60.80.7-0.70.6-0.50.60.1
Mn content in liver0.40.40.80.1-0.90.9-0.70.8-0.50.2
Na content in liver0.50.50.90.40.9-0.80.8-1.00.70.1
Rb content in liver1.51.82.9-1.6-1.31.3-1.50.8-1.7-1.0
Se content in liver1.82.24.50.51.9-1.91.3-2.10.8-1.0
Sr content in liver0.60.51.20.9-0.60.6-0.71.1-0.40.7
Zn content in liver0.70.83.92.00.8-0.80.30.10.40.5
Bone: minimum diameter0.00.00.10.0-0.10.0-0.10.3-0.1-0.1
Time in familiar zone, hab. session 11.11.01.60.2-1.11.3-1.31.0-1.20.3
Time in novel zone, hab. session 11.00.91.40.41.2-1.21.2-1.01.10.1
Total zone transitions, hab. session 10.71.04.9-2.2-0.80.8-0.30.2-0.3-0.8
Total locomotion distance, hab. session 10.30.42.0-1.4-0.20.3-0.1-0.4-0.3-0.7
Locomotion velocity, hab. session 10.60.94.2-2.1-0.60.6-0.4-0.2-0.5-0.8
Time in familiar zone, hab. session 20.20.20.70.80.1-0.1-0.1-0.4-0.20.5
Time in novel zone, hab. session 20.30.31.7-1.3-0.30.4-0.10.4-0.0-0.5
Total zone transitions, hab. session 20.20.20.8-0.10.3-0.20.7-0.20.90.2
Total locomotion distance, hab. session 20.10.10.7-0.8-0.20.30.10.10.1-0.3
Locomotion velocity, hab. session 20.10.10.6-0.8-0.30.30.10.10.2-0.3
Novel to familiar place preference ratio0.20.20.4-0.40.10.20.5-0.20.60.6
Novelty place preference0.20.20.4-0.7-0.10.40.2-0.00.40.5
Time in novel zone, NPP test0.10.10.4-0.50.10.20.3-0.10.50.6
Total zone transitions, NPP test0.10.20.3-0.40.4-0.40.5-0.40.5-0.2
Total locomotion distance, NPP test0.40.51.0-1.00.6-0.60.6-1.00.3-0.8
Locomotion velocity, NPP test0.40.61.5-1.20.6-0.60.6-0.80.4-1.0
Intraocular pressure0.30.40.80.60.9-0.90.4-0.10.2-0.8
Delta distance traveled before/after self-admin0.10.10.30.1-0.0-0.0-0.00.40.1-0.6
Delta ambulatory time before/after self-admin0.20.20.3-0.2-0.50.4-0.40.6-0.4-0.4
Parametrial fat weight0.30.62.61.60.3-0.40.2-0.20.41.1
Pavlov. Cond. lever latency1.01.33.31.81.3-0.90.9-0.51.00.9
Pavlov. Cond. magazine entry latency0.30.40.80.20.6-0.90.8-0.60.7-0.5
Pavlov. Cond. change in total contacts0.40.41.5-0.20.5-0.80.7-1.20.5-0.1
Pavlov. Cond. index score0.10.20.5-0.40.1-0.50.3-0.50.1-0.7
Pavlov. Cond. latency score0.20.20.5-0.7-0.0-0.40.2-0.50.1-0.7
Pavlov. Cond. lever contacts0.50.61.7-1.3-0.90.5-0.60.1-0.8-0.7
Pavlov. Cond. magazine entry number0.50.61.20.1-0.81.1-0.80.7-0.70.9
Pavlov. Cond. intertrial magazine entries1.11.41.9-1.1-1.41.4-1.21.3-1.1-0.4
Pavlov. Cond. lever-magazine prob. diff.0.10.10.4-0.20.1-0.50.2-0.50.1-0.6
Pavlov. Cond. response bias0.20.30.6-0.20.4-0.70.4-0.60.3-0.8
Pavlov. Cond. lever latency0.71.01.41.2-1.01.0-1.01.2-0.80.6
Pavlov. Cond. magazine entry latency0.50.51.7-1.30.4-0.40.6-1.10.4-0.4
Pavlov. Cond. change in total contacts0.30.41.7-1.30.4-0.40.6-0.50.5-0.4
Pavlov. Cond. index score0.50.72.8-1.70.4-0.40.6-0.80.4-0.8
Pavlov. Cond. latency score0.50.62.3-1.50.4-0.40.5-0.80.4-0.7
Pavlov. Cond. lever contacts0.50.71.5-1.20.8-0.80.6-1.10.4-0.7
Pavlov. Cond. magazine entry number0.40.53.11.80.0-0.0-0.30.5-0.10.5
Pavlov. Cond. intertrial magazine entries0.10.10.30.60.3-0.30.40.10.5-0.2
Pavlov. Cond. lever-magazine prob. diff.0.60.72.9-1.70.4-0.40.6-0.80.5-0.8
Pavlov. Cond. response bias0.71.03.7-1.90.6-0.50.6-1.10.3-0.9
Time in closed arm before self-admin0.30.30.60.70.5-0.40.40.30.5-0.7
Time in closed arm after self-admin2.52.516.3-0.70.2-0.10.40.70.6-4.0
Time in open arm before self-admin1.31.47.7-0.00.5-0.50.7-0.40.8-2.8
Time in open arm after self-admin1.01.17.10.50.1-0.2-0.1-0.5-0.22.7
Bone: periosteal estimation0.71.52.81.41.7-1.61.2-0.81.1-0.1
Bone: periosteal perimeter0.61.12.30.01.5-1.41.0-1.00.7-0.8
Bone: post-yield work0.10.20.80.20.2-0.3-0.30.0-0.5-0.9
Progressive ratio test 1 active lever presses0.20.20.60.30.5-0.50.6-0.20.7-0.1
Progressive ratio test 1 breakpoint0.40.40.90.50.6-0.60.8-0.41.00.3
Progressive ratio test 1 inactive lever presses0.10.10.5-0.1-0.0-0.00.30.70.50.3
Progressive ratio test 2 active lever presses0.60.71.3-0.30.8-0.81.0-0.21.1-1.0
Progressive ratio test 2 breakpoint0.50.61.3-0.60.6-0.61.0-0.11.1-0.9
Progressive ratio test 2 inactive lever presses0.50.62.8-0.0-0.0-0.0-0.01.20.2-1.7
Incentive Sensitization - Responses0.40.41.6-1.3-0.20.20.00.40.0-1.0
Incentive Sensitization - Breakpoint0.50.51.8-1.3-0.20.3-0.00.5-0.0-1.2
Sum of active levers in priming session hrs 5-60.80.84.10.30.3-0.3-0.0-1.0-0.22.0
Progressive ratio0.80.91.7-0.4-1.31.2-1.01.0-0.9-0.4
Food seeking constrained by brief footshock3.34.05.3-0.6-2.22.1-2.32.2-2.2-1.7
Seeking ratio, punishment vs. effort0.10.10.30.50.4-0.30.00.0-0.0-0.1
Retroperitoneal fat weight0.20.74.0-0.40.6-0.3-0.0-2.0-0.50.1
Reaction time number correct0.10.21.00.0-0.20.1-0.41.0-0.2-0.2
Reaction time mean minus median2.53.36.3-0.82.1-2.22.0-2.51.6-0.3
Reaction time mean minus median AUC0.50.72.9-1.70.4-0.60.6-0.80.3-0.6
Reaction time num false alarms0.50.72.1-1.40.4-0.50.7-0.50.6-1.0
Reaction time num false alarms AUC0.40.61.8-1.30.3-0.50.4-0.40.2-1.3
Reaction time trials correct on left0.10.21.00.0-0.20.1-0.41.0-0.2-0.2
Reaction time trials on left0.10.20.90.0-0.20.1-0.30.9-0.2-0.2
Reaction time mean0.30.51.8-1.3-0.2-0.10.4-1.00.30.3
Reaction time mean AUC0.40.52.5-1.6-0.30.10.2-0.90.10.1
Median of all reaction times0.40.62.0-1.4-1.00.7-0.2-0.4-0.20.4
Reaction time omissions0.20.31.3-1.20.0-0.20.3-0.70.1-0.2
Reaction time false alarm rate0.50.71.3-1.20.5-0.60.7-0.90.4-1.2
Reaction time premature initiation rate0.30.40.6-0.30.6-0.50.8-0.80.70.0
Reaction time premature initiations0.10.20.3-0.30.4-0.50.5-0.30.50.0
Std. dev. reaction times0.81.23.0-1.01.0-1.21.1-1.70.8-0.0
Reaction time trials completed0.10.20.90.0-0.20.1-0.30.9-0.2-0.2
Reaction time trials AUC0.20.31.2-0.2-0.30.3-0.51.1-0.4-0.4
Run reversals in cocaine runway, females0.60.50.7-0.7-0.70.8-0.80.6-0.9-0.7
Run reversals in cocaine runway, males1.31.23.0-1.0-1.00.8-0.71.4-0.5-1.7
Latency to leave start box in cocaine runway0.40.51.00.20.5-0.40.7-0.80.81.0
Latency to leave start box in cocaine runway, F0.80.91.91.30.7-0.60.7-0.70.91.4
Latency to leave start box in cocaine runway, M0.80.84.1-2.0-0.50.5-0.20.3-0.3-0.7
Std. dev. time between licks in bursts0.20.31.3-0.70.1-0.30.10.10.1-1.1
Total sessions with >9 infusions0.10.10.3-0.00.4-0.40.4-0.50.4-0.3
Short access day 1 total inactive lever presses0.20.20.40.1-0.50.5-0.40.7-0.2-0.3
Short access day 10 total inactive lever presses0.40.42.61.60.1-0.3-0.20.5-0.1-0.0
Short access day 1 total infusions0.80.81.6-0.1-1.11.1-1.20.5-1.30.1
Short access day 10 total infusions0.50.51.0-1.0-0.70.8-0.70.3-0.9-0.4
Short access total infusions0.10.10.30.4-0.10.1-0.1-0.6-0.10.5
Short access day 1 locomotion0.30.31.6-1.3-0.20.20.2-0.40.20.0
Short access day 10 total locomotion1.01.11.8-0.8-1.21.1-1.20.9-1.3-0.8
Short access total locomotion0.20.20.7-0.8-0.50.4-0.4-0.2-0.50.2
One hour access (0.3 mA shock)1.11.32.5-1.4-0.90.9-0.51.6-0.3-1.6
Compulsive drug intake2.52.54.1-1.7-2.02.0-1.51.5-1.40.3
One hour access (shock baseline)0.70.82.6-0.30.9-0.90.9-0.20.8-1.6
Social response proportion7.27.811.91.83.2-3.23.3-2.63.40.8
Social responses1.11.42.40.21.5-1.51.4-0.81.4-0.7
Social time0.71.04.4-2.1-1.01.1-0.30.3-0.2-0.1
Soleus weight0.30.92.11.01.5-1.40.7-0.40.4-0.5
Bone: stiffness0.71.01.70.11.3-1.31.3-0.91.2-0.1
Tibialis anterior weight4.916.628.04.05.3-5.34.1-3.83.70.1
Time to tail flick, vehicle, before self-admin0.60.61.5-0.30.5-0.40.9-1.20.9-0.9
Time to tail flick, vehicle, after self-admin0.10.10.7-0.80.00.00.3-0.30.3-0.1
Time to tail flick, test, before self-admin1.81.88.51.00.9-0.90.7-0.40.8-2.9
Time to tail flick, test, after self-admin0.40.51.10.70.7-0.70.6-1.00.5-0.4
Delta time to tail flick, vehicle, before/after SA0.70.71.0-0.9-0.90.9-0.90.9-1.0-0.2
Delta time to tail flick, test, before/after SA1.11.05.4-0.2-0.40.5-0.60.0-0.82.3
Tibia length3.610.222.04.73.2-3.43.0-2.43.21.7
Ambulatory time before self-admin0.40.41.8-1.30.2-0.20.4-0.70.2-0.6
Ambulatory time after self-admin0.30.41.6-0.80.2-0.10.2-0.40.1-1.3
Bone: tissue strength0.90.91.40.3-1.01.1-1.21.2-1.10.4
Total heroin consumption1.11.35.7-2.4-0.90.8-0.60.0-0.9-1.0
Bone: trabecular number1.32.15.62.41.9-1.80.9-0.90.80.2
Bone: trabecular spacing1.72.33.7-1.7-1.91.9-1.51.2-1.4-0.3
Bone: trabecular thickness1.82.24.42.02.0-2.11.0-1.10.7-0.4
Bone: trabecular tissue density2.63.76.4-0.42.1-2.12.4-2.52.2-0.0
Water consumed over 24 hours0.81.02.21.51.0-1.01.00.01.20.6
Number of responses in last shaping day0.20.20.7-0.2-0.20.3-0.20.4-0.2-0.8