Hub : Genes

Pigb

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Brain alternative TSS NM_001108166.3 0.04 0.03 3.0e-03 0.03 0.02 0.02 0.02 1.6e-03 2.3e-03 3.0e-03 5.1e-03
2 Brain alternative TSS XM_039081521.1 0.04 0.03 3.3e-03 0.03 0.02 0.02 0.02 1.6e-03 2.3e-03 2.6e-03 4.5e-03
3 Brain mRNA stability Pigb 0.05 0.03 1.3e-04 0.05 0.05 0.02 0.05 1.3e-05 3.1e-05 5.4e-03 1.4e-05
4 Adipose alternative polyA NM_001108166.3 0.04 0.02 1.1e-04 0.03 0.02 0.03 0.02 3.2e-04 1.9e-03 3.1e-04 9.1e-04
5 Adipose alternative polyA XM_039081521.1 0.03 0.02 1.2e-04 0.03 0.02 0.03 0.03 2.3e-04 1.2e-03 4.6e-04 5.1e-04
6 PL mRNA stability Pigb 0.03 0.02 2.8e-03 0.01 0.01 0 0.01 1.1e-02 1.4e-02 1.9e-01 3.2e-02
7 NAcc mRNA stability Pigb 0.03 0.02 1.3e-03 0.03 0.02 0.02 0.02 2.9e-04 1.8e-03 4.3e-03 1.5e-03
8 Liver gene expression Pigb 0.02 0.02 6.6e-03 0.01 0.01 0.01 0.01 9.8e-03 1.7e-02 9.5e-03 2.4e-02
9 Adipose gene expression Pigb 0.07 0.04 5.5e-09 0.05 0.05 0.06 0.05 2.8e-06 1.4e-06 5.0e-07 4.6e-06
10 Adipose mRNA stability Pigb 0.09 0.05 2.1e-08 0.07 0.05 0.05 0.07 2.9e-08 2.1e-06 1.4e-06 8.0e-08
11 Brain gene expression Pigb 0.09 0.04 3.7e-08 0.09 0.09 0.08 0.09 1.2e-08 2.1e-08 8.6e-08 8.0e-09
12 OFC gene expression Pigb 0.22 0.12 9.6e-03 0.07 0.05 0.07 0.06 1.1e-02 2.5e-02 1.2e-02 1.5e-02
13 NAcc gene expression Pigb 0.07 0.04 1.9e-07 0.05 0.06 0.04 0.06 6.1e-07 2.3e-07 1.3e-05 5.8e-07

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13
Bone: apparent density0.10.10.3-0.30.30.3-0.30.30.20.5-0.5-0.40.20.4-0.30.5
Area under the delay curve0.00.00.30.1-0.1-0.10.1-0.1-0.10.20.10.50.0-0.10.0-0.2
BMI with tail6.822.128.74.5-4.5-4.54.7-4.6-4.5-4.34.75.4-4.2-4.95.0-5.1
BMI without tail1.94.08.81.6-1.6-1.61.8-1.8-1.6-1.71.91.8-1.4-2.52.8-3.0
Body weight3.715.419.13.9-3.9-3.94.0-3.9-3.9-3.63.94.4-3.8-4.13.9-3.8
Weight adjusted by age5.56.27.82.6-2.6-2.62.1-2.2-2.0-2.82.52.6-2.6-2.72.5-2.5
Bone surface0.20.40.60.7-0.7-0.70.7-0.7-0.7-0.40.60.3-0.7-0.60.6-0.6
Bone volume0.30.50.70.8-0.8-0.80.7-0.7-0.8-0.60.60.6-0.8-0.60.6-0.4
Breakpoint value in progressive ratio session0.10.10.2-0.30.30.3-0.20.20.20.40.10.10.3-0.00.2-0.3
Number of licking bursts2.52.93.2-1.71.71.7-1.81.81.81.4-1.8-1.81.81.7-1.61.5
Context. condit. distance diff. score0.10.10.3-0.10.10.1-0.10.10.1-0.0-0.20.10.50.4-0.40.5
Locomotion velocity, session 11.11.21.81.1-1.1-1.11.1-1.1-1.1-0.91.01.0-0.8-1.31.4-1.1
Locomotion distance, session 10.20.20.7-0.60.60.6-0.50.50.50.5-0.5-0.30.80.4-0.10.2
Locomotion velocity, session 20.10.10.3-0.20.20.2-0.30.30.30.4-0.00.20.2-0.30.6-0.5
Locomotion distance, session 20.20.31.4-0.10.10.1-0.10.00.00.10.20.4-0.1-0.71.2-1.1
Locomotion velocity, session 30.10.10.3-0.20.20.2-0.40.40.40.3-0.3-0.50.3-0.10.6-0.4
Locomotion distance, session 32.83.13.9-1.81.81.8-1.91.91.91.8-1.9-2.01.71.6-1.31.2
Stereotopy head waving bouts, day 31.01.21.71.3-1.3-1.31.2-1.2-1.2-1.01.31.1-1.0-0.90.7-0.5
Stereotopy head waving duration, day 32.12.53.21.8-1.8-1.81.7-1.8-1.8-1.41.71.6-1.5-1.41.1-0.8
Locomotion velocity, session 70.80.91.4-1.01.01.0-1.01.01.01.0-0.9-1.20.90.9-0.90.8
Locomotion distance, session 71.41.82.5-1.51.51.5-1.41.41.41.6-1.4-1.61.21.2-0.80.8
Stereotopy head waving bouts, day 70.81.01.61.0-1.0-1.00.9-0.9-0.9-0.70.90.8-0.8-1.21.3-1.1
Stereotopy head waving duration, day 70.91.11.81.1-1.1-1.11.0-1.0-1.0-0.81.10.7-0.8-1.31.3-1.2
Locomotion velocity, session 80.20.20.90.2-0.2-0.20.3-0.3-0.3-0.20.50.2-0.1-0.60.9-0.7
Locomotion distance, session 80.40.61.2-1.01.01.0-0.90.90.91.0-0.7-0.61.10.50.00.0
Degree of sensitization distance0.00.00.1-0.20.20.2-0.10.10.10.4-0.1-0.20.00.1-0.10.1
Degree of sensitization stereotypy0.80.81.70.9-0.9-0.90.8-0.8-0.8-0.70.70.8-0.8-1.21.3-1.2
Conditioned locomotion0.20.21.10.2-0.2-0.20.4-0.4-0.4-0.40.11.0-0.6-0.50.3-0.5
Cocaine response after cond. corrected6.47.28.93.0-3.0-3.02.7-2.7-2.8-2.92.72.5-2.8-2.62.2-1.9
Cocaine response after cond. not corrected4.95.47.02.6-2.6-2.62.4-2.4-2.4-2.62.32.2-2.4-2.11.7-1.4
Cocaine response before conditioning1.11.41.7-1.31.31.3-1.21.21.21.1-1.1-0.81.31.3-1.11.0
Saline control response0.10.10.20.3-0.3-0.30.4-0.4-0.3-0.2-0.1-0.0-0.4-0.0-0.10.3
Bone: connectivity density1.52.33.4-1.51.51.5-1.61.61.51.7-1.7-1.81.31.4-1.11.2
Bone: cortical apparent density0.50.60.9-0.70.70.7-0.70.80.80.7-0.9-0.60.90.8-0.91.0
Bone: cortical area1.42.02.91.7-1.7-1.71.7-1.7-1.7-1.41.11.5-1.7-0.90.2-0.1
Bone: cortical porosity0.40.51.1-0.50.50.5-0.60.60.60.6-0.7-0.30.70.9-1.01.0
Bone: cortical porosity1.21.32.1-1.11.11.1-1.11.11.11.0-1.0-0.81.21.4-1.41.5
Bone: cortical thickness0.20.31.60.1-0.1-0.10.1-0.1-0.10.1-0.60.0-0.00.7-1.21.3
Bone: cortical thickness0.20.21.1-0.10.10.1-0.00.00.0-0.2-0.1-0.10.20.5-1.01.1
Bone: cortical tissue density0.50.70.9-0.80.80.8-0.80.80.80.8-0.9-0.60.90.8-0.91.0
Condit. Reinf. active minus inactive responses1.01.11.7-1.31.31.3-1.31.31.21.1-0.9-0.51.10.9-0.50.2
Condit. Reinf. active-inactive response ratio0.40.41.4-0.60.60.6-0.50.50.50.3-0.2-0.30.50.9-1.20.9
Condit. Reinf. active responses0.81.01.7-1.31.31.3-1.21.21.21.0-0.8-0.51.20.40.4-0.5
Condit. Reinf. inactive responses0.60.81.8-1.01.01.0-0.80.70.80.8-0.7-0.51.0-0.31.3-1.1
Incentive salience index mean0.60.71.3-1.11.11.1-1.11.01.00.7-0.6-0.00.90.6-0.2-0.1
Condit. Reinf. lever presses0.40.51.1-1.11.11.1-0.90.90.90.3-0.50.30.70.40.1-0.2
Condit. Reinf. active minus inactive responses2.32.83.51.6-1.6-1.61.7-1.7-1.7-1.51.61.8-1.9-1.81.8-1.4
Condit. Reinf. active-inactive response ratio2.62.73.41.7-1.7-1.71.8-1.8-1.8-1.71.61.6-1.9-1.61.1-1.0
Condit. Reinf. active responses1.21.62.71.1-1.1-1.11.2-1.2-1.2-1.11.11.6-1.4-1.51.5-1.2
Condit. Reinf. inactive responses0.60.71.1-1.01.01.0-1.01.00.91.1-1.0-0.40.80.5-0.00.2
Condit. Reinf. lever presses0.10.21.2-0.20.20.2-0.10.10.10.1-0.40.00.00.4-0.81.1
Condit. Reinf. lever reinforcers received0.91.22.31.0-1.0-1.01.1-1.1-1.1-0.90.91.5-1.3-1.31.2-1.0
Conditioned reinforcement - actives0.00.00.10.2-0.2-0.20.0-0.00.1-0.30.2-0.20.1-0.10.1-0.2
Conditioned reinforcement - inactives0.10.10.40.6-0.6-0.60.4-0.4-0.4-0.10.0-0.0-0.4-0.30.0-0.1
Conditioned locomotion0.20.20.6-0.20.20.2-0.70.60.50.3-0.3-0.10.60.6-0.80.5
Patch foraging indifference point 0 sec0.10.10.30.5-0.5-0.50.3-0.3-0.2-0.40.30.10.1-0.40.4-0.4
Patch foraging indifference point AUC1.92.23.2-1.81.81.8-1.81.71.61.8-1.3-1.31.70.9-0.20.2
Delay disc. indifference point, 0s delay1.21.32.6-1.21.21.2-1.21.21.21.6-1.1-1.01.21.0-0.70.4
Delay disc. indifference point, 16s delay0.10.10.30.0-0.0-0.00.1-0.0-0.00.1-0.10.40.10.3-0.50.5
Delay disc. indifference point, 2s delay0.10.10.3-0.20.20.2-0.20.20.20.4-0.3-0.50.40.3-0.30.3
Delay disc. indifference point, 24s delay0.10.10.3-0.20.20.2-0.10.20.30.6-0.50.10.40.3-0.40.4
Delay disc. indifference point, 4s delay0.30.30.4-0.60.60.6-0.50.50.60.6-0.4-0.20.50.6-0.50.4
Delay disc. indifference point, 8s delay0.40.41.00.4-0.4-0.40.5-0.6-0.5-0.10.60.9-0.3-0.70.8-1.0
Indifference point function ln k2.33.25.22.0-2.0-2.02.1-2.1-1.8-2.31.91.6-1.9-1.20.6-0.7
Indifference point function log k2.33.25.22.0-2.0-2.02.1-2.1-1.8-2.31.91.6-1.9-1.20.6-0.7
Patch foraging total patch changes 0 sec0.20.30.60.8-0.8-0.80.6-0.6-0.4-0.50.40.3-0.2-0.60.6-0.5
Patch foraging total patch changes 12 sec0.60.81.5-0.90.90.9-1.00.90.91.2-1.0-1.11.20.6-0.20.3
Patch foraging total patch changes 18 sec0.10.10.3-0.20.20.2-0.20.20.10.5-0.4-0.40.50.1-0.00.1
Patch foraging total patch changes 24 sec0.50.61.6-0.70.70.7-0.80.80.71.1-0.9-1.31.00.30.0-0.2
Patch foraging total patch changes 6 sec0.30.40.8-0.60.60.6-0.70.70.60.9-0.6-0.60.9-0.00.6-0.7
Patch foraging time to switch 0 sec0.71.01.7-0.90.90.9-1.11.10.90.8-0.9-1.10.81.1-1.21.3
Patch foraging water rate 0 sec2.23.54.12.0-2.0-2.01.9-2.0-1.8-1.71.81.9-1.8-1.91.7-1.8
Patch foraging water rate 12 sec3.45.36.62.6-2.6-2.62.4-2.4-2.3-1.72.02.0-2.4-2.42.1-2.2
Patch foraging water rate 18 sec0.50.61.01.0-1.0-1.00.9-0.9-0.8-0.40.60.7-0.8-0.70.6-0.7
Patch foraging water rate 24 sec0.10.20.3-0.40.40.4-0.10.20.50.5-0.5-0.50.40.5-0.40.2
Patch foraging water rate 6 sec0.40.61.00.9-0.9-0.91.0-1.0-0.8-0.30.80.3-1.0-0.70.6-0.8
Seeking ratio, delayed vs. immediate footshock1.21.43.01.0-1.0-1.01.0-1.0-1.0-1.11.70.9-1.2-1.21.3-1.7
Distance traveled before self-admin0.10.10.30.3-0.3-0.3-0.00.1-0.1-0.30.5-0.1-0.30.0-0.2-0.1
Distance traveled after self-admin2.73.03.91.8-1.8-1.81.8-1.8-2.0-2.01.91.3-2.0-1.71.4-1.0
Extensor digitorum longus weight7.228.233.15.1-5.1-5.15.3-5.3-5.4-5.25.64.9-4.7-5.75.8-5.7
Bone: elastic displacement0.00.10.10.2-0.2-0.20.3-0.3-0.2-0.10.20.3-0.0-0.30.2-0.3
Bone: elastic work0.00.00.10.1-0.1-0.10.1-0.1-0.1-0.20.10.30.10.0-0.30.3
Bone: endosteal estimation2.86.07.92.4-2.4-2.42.5-2.5-2.4-2.52.82.4-2.5-2.42.3-2.4
Bone: endosteal perimeter4.38.910.93.0-3.0-3.03.1-3.1-3.0-2.83.03.1-3.3-2.92.7-2.7
Epididymis fat weight0.20.51.5-0.60.60.6-0.80.90.81.2-0.9-1.10.60.00.20.2
Delta time in closed arm before/after self-admin0.20.20.50.5-0.5-0.50.6-0.6-0.4-0.50.20.7-0.5-0.30.10.1
Delta time in open arm before/after self-admin1.31.32.8-1.01.01.0-1.31.31.00.9-1.2-1.70.81.0-0.91.3
Diff in mean of infusions in LGA sessions0.50.61.7-0.10.10.10.6-0.6-0.6-0.91.31.20.0-0.61.0-1.1
Delay discount exponential model param0.00.10.3-0.20.20.2-0.20.20.1-0.1-0.2-0.50.10.1-0.10.3
Extinction: sum of active levers before priming0.70.71.1-0.70.70.7-0.90.91.00.8-0.9-0.80.60.9-1.01.0
Active lever presses in extinction session 60.10.10.3-0.40.40.4-0.30.30.20.10.2-0.60.40.2-0.1-0.0
Bone: final force1.42.22.91.5-1.5-1.51.6-1.6-1.6-1.71.51.7-1.7-1.31.0-0.9
Bone: final moment1.21.92.61.4-1.4-1.41.5-1.6-1.5-1.61.41.6-1.6-1.10.7-0.6
Food consumed during 24 hour testing period1.41.72.81.4-1.4-1.41.5-1.5-1.5-1.71.51.2-1.3-0.80.6-0.5
Glucose0.50.71.20.8-0.8-0.80.8-0.8-0.8-0.91.10.7-0.5-0.90.9-0.9
Heart weight0.50.71.10.8-0.8-0.80.8-0.8-0.9-0.40.40.9-1.1-1.01.0-0.9
Delay discount hyperbolic model param0.00.00.1-0.00.00.0-0.10.10.0-0.2-0.1-0.3-0.0-0.00.00.1
Intermittent access intake day 1-15 change0.10.10.7-0.20.20.2-0.00.00.20.4-0.6-0.80.30.10.00.1
Intermittent access intake escalation0.20.21.1-0.40.40.4-0.20.20.40.3-0.4-1.00.50.3-0.20.2
Intermittent access intake escalation 20.10.10.20.3-0.3-0.30.4-0.4-0.2-0.20.3-0.2-0.2-0.30.3-0.4
Intermitt. access day 1 inactive lever presses0.20.20.9-0.10.10.10.5-0.40.0-0.5-0.10.10.20.6-0.91.0
Intermitt. access day 15 inactive lever presses0.10.10.2-0.10.10.10.3-0.3-0.00.5-0.30.20.30.3-0.30.4
Intermitt. access escalation Index0.90.81.61.2-1.2-1.20.5-0.5-0.6-0.40.51.1-1.3-0.90.6-0.9
Intermittent access day 1 total infusions0.30.41.7-0.00.00.0-0.40.30.30.2-0.3-0.80.40.8-1.31.2
Intermittent access day 15 total infusions0.50.62.0-0.40.40.4-0.60.50.60.6-0.5-1.40.70.9-1.21.0
Intermittent access terminal intake (last 3 days)0.30.31.3-0.30.30.3-0.40.30.40.3-0.2-0.80.60.8-1.20.9
Intermittent access total infusions0.30.31.30.1-0.1-0.1-0.30.20.30.1-0.2-1.00.30.7-1.11.1
Intermittent access day 1 locomotion1.01.02.9-0.60.60.6-1.00.91.00.4-0.7-1.10.91.3-1.71.6
Intermittent access day 15 total locomotion0.50.52.30.0-0.0-0.0-0.50.40.40.3-0.3-0.90.10.9-1.51.3
Intermittent access total locomotion0.10.10.50.5-0.5-0.5-0.10.00.0-0.20.1-0.2-0.20.3-0.70.6
Intermittent access standard deviation0.30.41.4-0.30.30.3-0.30.30.40.2-0.4-1.20.60.7-1.00.7
Left kidney weight2.77.79.43.0-3.0-3.02.9-2.9-3.1-2.72.43.0-3.1-2.72.4-2.1
Right kidney weight1.33.64.71.9-1.9-1.91.8-1.8-1.9-1.91.72.2-1.7-2.02.1-1.8
Cocaine induced anxiety0.50.61.0-0.90.90.9-0.90.90.80.8-0.6-0.41.00.5-0.20.0
Post-drug Anxiety3.43.85.9-2.42.42.4-2.02.12.01.7-1.7-2.02.41.6-1.10.9
Baseline Anxiety1.11.12.4-1.11.11.1-1.11.11.11.0-1.1-1.61.00.9-0.80.8
Tail length0.41.12.1-1.21.21.2-1.11.21.30.9-1.1-1.51.00.7-0.50.5
Length with tail0.10.41.00.8-0.8-0.80.6-0.6-0.8-0.70.40.6-1.0-0.60.4-0.2
Length without tail2.86.18.42.8-2.8-2.82.6-2.6-2.8-2.32.32.9-2.9-2.01.4-1.0
Times rat made contact with spout0.00.10.20.1-0.1-0.10.2-0.2-0.20.0-0.20.30.20.3-0.40.4
Lifetime Intake0.40.41.4-0.10.10.1-0.50.40.40.3-0.3-1.20.50.8-1.21.1
Liver weight, left0.81.32.31.1-1.1-1.11.1-1.0-1.0-1.51.21.2-0.9-1.31.3-1.2
Liver weight, right1.62.64.51.3-1.3-1.31.5-1.5-1.4-1.91.81.6-1.0-1.72.1-2.0
Locomotor activity5.58.710.13.2-3.2-3.23.1-3.1-2.9-2.82.93.0-3.1-2.92.6-2.4
Locomotor testing distance3.66.17.62.8-2.8-2.82.6-2.6-2.5-2.42.22.4-2.6-2.42.1-1.8
Locomotor testing rearing0.81.31.71.2-1.2-1.21.1-1.1-1.0-1.21.00.9-1.1-1.31.3-1.0
Locomotion in novel chamber0.30.41.7-0.30.30.3-0.20.20.2-0.3-0.4-0.60.51.0-1.31.3
Locomotion in novel chamber post-restriction0.20.20.4-0.60.60.6-0.30.40.60.6-0.5-0.30.60.4-0.30.4
Fecal boli incidents, locomotor time 10.30.40.9-0.50.50.5-0.90.90.71.0-0.7-0.20.20.5-0.50.2
Change in fecal boli incidents, locomotor task3.02.85.01.8-1.8-1.82.1-2.1-1.9-2.22.01.1-1.4-1.20.8-0.7
Time >=10cm from walls, locomotor time 10.80.81.30.6-0.6-0.60.8-0.8-1.0-1.10.91.1-0.8-0.91.0-1.0
Bouts of movement, locomotor time 10.10.10.50.0-0.0-0.0-0.00.00.00.00.20.7-0.3-0.30.5-0.5
Total resting periods, locomotor time 10.00.10.4-0.00.00.0-0.10.10.10.10.10.6-0.3-0.20.3-0.3
Rest time, locomotor task time 10.10.10.5-0.00.00.0-0.40.40.30.2-0.40.40.10.5-0.70.6
Distance moved, locomotor task time 10.10.10.8-0.40.40.4-0.20.20.30.3-0.2-0.90.30.10.2-0.1
Vertical activity count, locomotor time 10.20.20.6-0.30.30.3-0.60.60.40.4-0.2-0.80.40.1-0.0-0.0
Time >=10cm from walls, locomotor time 20.10.10.30.4-0.4-0.40.1-0.0-0.2-0.30.10.5-0.3-0.30.2-0.3
Bouts of movement, locomotor time 20.60.62.00.6-0.6-0.60.7-0.7-0.5-0.30.60.7-0.7-1.01.3-1.4
Total resting periods, locomotor time 20.60.72.00.7-0.7-0.70.7-0.7-0.5-0.30.70.9-0.7-1.01.2-1.4
Rest time, locomotor task time 20.20.20.8-0.40.40.4-0.30.30.30.1-0.30.10.60.8-0.90.8
Distance moved, locomotor task time 20.10.10.6-0.10.10.1-0.20.20.30.1-0.2-0.8-0.1-0.30.4-0.4
Vertical activity count, locomotor time 20.91.02.9-0.70.70.7-1.21.21.11.1-1.1-1.70.60.7-0.80.8
Light reinforcement 11.93.55.41.7-1.7-1.71.6-1.6-1.7-1.61.72.3-1.7-2.22.3-2.3
Light reinforcement 20.30.31.9-0.10.10.1-0.0-0.0-0.0-0.4-0.10.10.20.9-1.41.2
Bone: marrow area3.06.58.42.5-2.5-2.52.6-2.6-2.6-2.72.92.5-2.6-2.52.3-2.4
Bone: maximum diameter4.17.69.43.0-3.0-3.03.1-3.1-3.0-2.62.62.8-3.0-2.41.9-2.0
Bone: maximum force1.42.43.01.6-1.6-1.61.6-1.6-1.7-1.61.51.7-1.6-1.51.2-1.0
Bone: maximum moment1.22.12.71.6-1.6-1.61.6-1.6-1.6-1.61.41.6-1.6-1.30.9-0.7
Mean time between licks in bursts0.91.32.1-1.01.01.0-1.01.01.01.1-1.0-1.41.01.4-1.41.3
Mean num. licks in bursts2.73.24.11.9-1.9-1.92.0-2.0-2.0-1.51.72.0-1.7-1.51.3-1.2
Cd content in liver0.30.30.8-0.60.60.6-0.70.70.70.9-0.7-0.60.50.10.0-0.2
Co content in liver0.10.20.3-0.40.40.4-0.40.40.30.5-0.50.30.60.3-0.1-0.1
Cu content in liver0.30.41.20.5-0.5-0.50.4-0.4-0.5-0.80.61.1-0.6-0.60.8-0.6
Fe content in liver1.01.21.8-1.21.21.2-1.01.01.11.2-1.1-1.41.20.8-0.50.7
K content in liver1.01.01.31.0-1.0-1.01.1-1.1-1.0-0.80.81.1-0.8-1.01.1-0.7
Mg content in liver2.82.93.91.6-1.6-1.61.7-1.7-1.6-1.71.62.0-1.6-1.81.8-1.6
Mn content in liver0.70.81.90.9-0.9-0.91.0-1.0-1.0-1.20.71.4-0.7-0.40.10.2
Na content in liver1.21.31.81.1-1.1-1.11.1-1.1-1.1-1.31.11.3-0.7-1.21.3-1.2
Rb content in liver1.72.13.61.3-1.3-1.31.5-1.4-1.5-1.11.41.1-1.4-1.71.9-1.7
Se content in liver0.50.61.2-0.70.70.7-0.60.60.70.7-1.1-0.90.10.5-0.71.1
Sr content in liver0.80.70.9-0.90.90.9-0.90.90.91.0-0.9-0.80.90.8-0.70.5
Zn content in liver0.10.10.3-0.40.40.4-0.20.20.20.2-0.30.00.40.5-0.60.5
Bone: minimum diameter0.51.01.81.1-1.1-1.11.2-1.2-1.1-0.90.81.3-1.2-0.50.1-0.1
Time in familiar zone, hab. session 10.00.00.3-0.10.10.10.00.00.00.2-0.20.20.60.00.1-0.1
Time in novel zone, hab. session 10.10.10.30.1-0.1-0.1-0.10.10.10.2-0.1-0.4-0.50.1-0.40.5
Total zone transitions, hab. session 10.40.61.4-0.70.70.7-0.80.80.81.1-1.2-1.00.80.4-0.00.1
Total locomotion distance, hab. session 10.20.20.5-0.50.50.5-0.50.50.50.7-0.6-0.40.50.10.4-0.3
Locomotion velocity, hab. session 10.10.10.3-0.20.20.2-0.20.20.20.4-0.2-0.10.1-0.20.6-0.6
Time in familiar zone, hab. session 20.10.10.5-0.40.40.4-0.30.30.30.3-0.5-0.70.40.2-0.20.3
Time in novel zone, hab. session 20.40.40.60.7-0.7-0.70.7-0.7-0.7-0.60.80.8-0.7-0.30.0-0.1
Total zone transitions, hab. session 20.30.30.5-0.60.60.6-0.60.70.70.7-0.60.10.50.00.7-0.7
Total locomotion distance, hab. session 20.20.21.0-0.40.40.4-0.30.30.30.4-0.30.50.2-0.31.0-1.0
Locomotion velocity, hab. session 20.10.20.6-0.40.40.4-0.30.30.30.4-0.30.40.3-0.20.8-0.8
Novel to familiar place preference ratio1.11.22.31.0-1.0-1.00.9-0.9-0.9-1.01.21.5-1.0-1.21.1-1.1
Novelty place preference1.41.42.81.1-1.1-1.11.1-1.1-1.1-1.11.41.7-1.1-1.31.2-1.2
Time in novel zone, NPP test1.92.03.31.4-1.4-1.41.3-1.3-1.3-1.41.61.8-1.4-1.41.3-1.2
Total zone transitions, NPP test0.10.20.6-0.20.20.2-0.20.20.20.4-0.30.50.2-0.30.8-0.8
Total locomotion distance, NPP test0.20.21.2-0.00.00.00.00.00.00.2-0.10.4-0.1-0.51.1-1.0
Locomotion velocity, NPP test0.20.30.6-0.50.50.5-0.50.50.50.7-0.6-0.10.4-0.20.8-0.7
Intraocular pressure0.00.10.30.1-0.1-0.10.0-0.0-0.00.5-0.4-0.5-0.1-0.0-0.00.0
Delta distance traveled before/after self-admin3.74.05.32.0-2.0-2.02.2-2.3-2.3-2.31.91.7-1.9-2.01.9-1.2
Delta ambulatory time before/after self-admin2.73.04.41.8-1.8-1.82.0-2.1-2.1-1.91.61.3-1.8-1.61.3-0.7
Parametrial fat weight0.51.01.9-0.70.70.7-0.90.80.91.2-1.3-1.40.91.0-1.00.8
Pavlov. Cond. lever latency0.50.71.11.0-1.0-1.01.0-1.0-1.1-0.80.80.0-0.9-0.3-0.30.4
Pavlov. Cond. magazine entry latency3.24.15.7-2.42.42.4-2.22.22.22.1-2.0-1.12.41.8-1.31.2
Pavlov. Cond. change in total contacts0.70.71.4-1.21.21.2-1.01.01.00.7-0.7-0.10.90.6-0.20.0
Pavlov. Cond. index score2.93.75.4-2.32.32.3-2.22.22.21.9-1.9-1.22.21.6-0.90.8
Pavlov. Cond. latency score2.43.04.5-2.12.12.1-2.02.02.01.7-1.7-1.02.01.3-0.70.6
Pavlov. Cond. lever contacts0.81.01.6-1.31.31.3-1.31.31.30.9-0.9-0.40.90.6-0.20.1
Pavlov. Cond. magazine entry number3.44.25.72.4-2.4-2.42.2-2.2-2.2-2.22.01.4-2.2-1.91.4-1.2
Pavlov. Cond. intertrial magazine entries0.10.10.4-0.10.10.1-0.10.10.1-0.00.1-0.30.2-0.20.6-0.6
Pavlov. Cond. lever-magazine prob. diff.2.63.24.7-2.22.22.2-2.12.12.11.8-1.7-1.12.01.4-0.80.6
Pavlov. Cond. response bias2.02.43.6-1.91.91.9-1.81.81.81.6-1.4-0.81.71.3-0.80.7
Pavlov. Cond. lever latency0.60.81.41.0-1.0-1.01.0-1.0-1.0-1.21.00.6-0.7-0.80.8-0.8
Pavlov. Cond. magazine entry latency4.14.76.4-2.12.12.1-2.12.12.02.3-2.5-2.31.62.2-2.32.2
Pavlov. Cond. change in total contacts1.01.32.0-1.11.11.1-1.11.11.21.3-1.4-1.00.91.2-1.11.1
Pavlov. Cond. index score1.72.13.2-1.51.51.5-1.51.51.41.8-1.8-1.41.01.3-1.41.4
Pavlov. Cond. latency score1.11.42.2-1.11.11.1-1.11.11.11.5-1.5-1.20.61.1-1.31.2
Pavlov. Cond. lever contacts0.40.60.8-0.80.80.8-0.80.80.80.9-0.8-0.40.60.7-0.70.6
Pavlov. Cond. magazine entry number3.54.25.52.1-2.1-2.12.0-2.0-1.9-2.42.32.3-1.4-2.02.1-2.0
Pavlov. Cond. intertrial magazine entries0.81.11.31.1-1.1-1.11.1-1.1-1.1-1.01.11.0-0.8-1.11.0-0.8
Pavlov. Cond. lever-magazine prob. diff.2.02.53.7-1.61.61.6-1.61.61.61.9-1.9-1.51.11.5-1.61.5
Pavlov. Cond. response bias1.82.43.4-1.71.71.7-1.61.61.61.8-1.7-1.21.31.4-1.41.3
Time in closed arm before self-admin0.20.30.7-0.60.60.6-0.40.40.50.7-0.3-0.20.80.5-0.40.2
Time in closed arm after self-admin0.00.00.10.2-0.2-0.20.4-0.4-0.20.00.20.20.0-0.10.2-0.1
Time in open arm before self-admin2.02.12.61.6-1.6-1.61.5-1.4-1.6-1.41.51.6-1.5-1.41.2-1.0
Time in open arm after self-admin0.10.10.30.3-0.3-0.30.0-0.0-0.3-0.40.2-0.1-0.5-0.0-0.20.4
Bone: periosteal estimation3.16.37.42.6-2.6-2.62.7-2.7-2.7-2.62.62.6-2.7-2.21.8-1.9
Bone: periosteal perimeter3.45.66.92.4-2.4-2.42.5-2.5-2.4-2.42.32.5-2.6-2.21.9-1.8
Bone: post-yield work0.10.20.70.3-0.3-0.30.2-0.2-0.3-0.30.40.5-0.2-0.60.8-0.6
Progressive ratio test 1 active lever presses0.20.20.40.7-0.7-0.70.4-0.4-0.6-0.60.50.1-0.4-0.30.1-0.1
Progressive ratio test 1 breakpoint0.10.10.10.3-0.3-0.30.1-0.1-0.3-0.30.3-0.1-0.00.1-0.40.3
Progressive ratio test 1 inactive lever presses0.40.51.7-0.30.30.3-0.20.20.4-0.2-0.2-1.30.60.9-1.21.1
Progressive ratio test 2 active lever presses0.70.81.41.2-1.2-1.20.9-0.9-0.9-0.31.10.1-0.9-0.70.4-0.8
Progressive ratio test 2 breakpoint1.01.12.01.4-1.4-1.41.0-1.1-1.1-0.51.10.2-1.2-0.90.5-0.8
Progressive ratio test 2 inactive lever presses0.20.31.20.2-0.2-0.20.1-0.10.10.5-0.3-0.80.10.6-1.11.0
Incentive Sensitization - Responses1.81.92.71.6-1.6-1.61.3-1.4-1.4-0.71.40.9-1.5-1.41.0-1.4
Incentive Sensitization - Breakpoint1.41.52.21.5-1.5-1.51.2-1.2-1.2-0.51.20.7-1.4-1.20.9-1.3
Sum of active levers in priming session hrs 5-60.20.20.30.4-0.4-0.40.3-0.3-0.5-0.60.50.5-0.5-0.50.5-0.3
Progressive ratio0.60.71.6-1.31.31.3-0.70.70.80.3-0.4-0.21.10.9-0.60.3
Food seeking constrained by brief footshock0.50.61.30.8-0.8-0.80.7-0.8-0.5-0.70.70.5-0.7-0.90.9-1.2
Seeking ratio, punishment vs. effort3.03.75.82.4-2.4-2.41.8-1.7-1.7-1.31.51.2-2.2-2.11.9-1.9
Retroperitoneal fat weight0.00.10.6-0.20.20.20.00.0-0.10.8-0.5-0.10.1-0.30.6-0.2
Reaction time number correct1.72.53.61.5-1.5-1.51.5-1.5-1.4-1.81.31.5-1.7-1.81.9-1.6
Reaction time mean minus median0.40.50.8-0.60.60.6-0.90.90.90.8-0.7-0.80.60.8-0.80.8
Reaction time mean minus median AUC1.01.31.8-1.01.01.0-1.31.31.31.3-1.1-1.11.01.1-1.21.2
Reaction time num false alarms0.20.20.4-0.40.40.4-0.50.50.50.5-0.6-0.60.50.3-0.30.6
Reaction time num false alarms AUC0.00.00.00.1-0.1-0.1-0.10.00.00.2-0.2-0.10.0-0.20.20.1
Reaction time trials correct on left1.72.53.61.5-1.5-1.51.5-1.5-1.4-1.81.31.5-1.7-1.81.9-1.6
Reaction time trials on left1.72.53.61.5-1.5-1.51.5-1.4-1.4-1.71.31.5-1.7-1.81.9-1.6
Reaction time mean2.84.05.6-1.81.81.8-2.02.02.01.8-1.8-2.11.82.2-2.42.2
Reaction time mean AUC3.04.05.4-1.91.91.9-2.02.12.01.8-1.7-2.11.92.2-2.32.1
Median of all reaction times3.44.76.6-2.02.02.0-2.12.22.11.9-1.9-2.22.02.4-2.62.5
Reaction time omissions0.00.00.2-0.20.20.2-0.20.20.30.2-0.1-0.50.00.00.0-0.0
Reaction time false alarm rate0.71.01.4-0.90.90.9-1.01.00.91.2-1.0-1.11.11.0-1.01.1
Reaction time premature initiation rate0.60.81.50.6-0.6-0.60.9-0.9-0.8-1.20.91.1-0.6-1.01.2-1.0
Reaction time premature initiations2.02.84.21.4-1.4-1.41.6-1.6-1.5-2.01.51.9-1.5-1.92.1-1.7
Std. dev. reaction times1.82.63.1-1.41.41.4-1.71.71.71.6-1.6-1.71.51.7-1.71.7
Reaction time trials completed1.72.53.61.5-1.5-1.51.5-1.4-1.4-1.71.31.5-1.7-1.81.9-1.6
Reaction time trials AUC1.62.23.31.4-1.4-1.41.4-1.4-1.3-1.61.21.4-1.7-1.71.8-1.5
Run reversals in cocaine runway, females0.30.20.60.4-0.4-0.40.6-0.7-0.7-0.60.20.2-0.8-0.40.30.1
Run reversals in cocaine runway, males0.20.20.7-0.10.10.1-0.20.20.20.6-0.0-0.20.3-0.40.8-0.8
Latency to leave start box in cocaine runway1.61.72.11.4-1.4-1.41.0-1.0-1.0-1.21.41.3-1.5-1.41.4-1.4
Latency to leave start box in cocaine runway, F0.20.20.70.4-0.4-0.40.2-0.1-0.3-0.30.60.2-0.4-0.70.8-0.8
Latency to leave start box in cocaine runway, M3.33.14.82.2-2.2-2.21.5-1.4-1.6-1.41.41.9-2.2-1.71.4-1.6
Std. dev. time between licks in bursts0.00.00.2-0.00.00.0-0.00.0-0.1-0.0-0.0-0.1-0.4-0.30.2-0.2
Total sessions with >9 infusions0.20.21.10.3-0.3-0.30.4-0.4-0.6-1.00.7-0.3-0.0-0.10.10.1
Short access day 1 total inactive lever presses1.21.42.41.4-1.4-1.41.4-1.4-1.3-1.60.90.5-1.4-0.90.4-0.0
Short access day 10 total inactive lever presses0.20.31.1-0.20.20.2-0.20.20.60.3-0.5-0.50.10.6-0.91.1
Short access day 1 total infusions0.10.10.40.2-0.2-0.2-0.30.3-0.0-0.4-0.0-0.6-0.00.3-0.60.5
Short access day 10 total infusions0.40.41.2-0.30.30.3-0.50.50.50.3-0.3-1.10.60.8-1.11.1
Short access total infusions0.60.72.0-0.40.40.4-0.70.70.60.1-0.5-1.30.91.0-1.41.4
Short access day 1 locomotion0.10.10.60.4-0.4-0.40.1-0.1-0.4-0.80.50.1-0.2-0.20.1-0.2
Short access day 10 total locomotion0.30.30.60.7-0.7-0.70.5-0.5-0.4-0.80.50.4-0.7-0.1-0.30.3
Short access total locomotion0.50.51.7-0.20.20.2-0.60.60.6-0.2-0.3-0.70.40.9-1.31.3
One hour access (0.3 mA shock)0.30.30.50.7-0.7-0.70.7-0.7-0.7-0.70.60.0-0.4-0.2-0.1-0.1
Compulsive drug intake0.70.72.30.6-0.6-0.61.0-1.1-1.0-1.50.80.7-0.5-0.50.5-0.3
One hour access (shock baseline)0.30.30.8-0.20.20.2-0.50.50.60.8-0.2-0.90.40.6-0.90.7
Social response proportion0.70.71.50.7-0.7-0.70.9-1.0-0.9-1.21.21.2-0.8-0.50.3-0.4
Social responses0.10.10.30.3-0.3-0.30.4-0.5-0.3-0.30.30.5-0.2-0.40.4-0.5
Social time0.30.40.60.8-0.8-0.80.6-0.6-0.6-0.60.70.6-0.7-0.60.5-0.4
Soleus weight14.742.951.16.3-6.3-6.36.3-6.3-6.4-6.56.96.4-6.1-7.07.1-7.1
Bone: stiffness1.72.63.01.7-1.7-1.71.7-1.7-1.7-1.61.71.2-1.6-1.61.6-1.4
Tibialis anterior weight14.248.455.37.0-7.0-7.07.1-7.1-7.2-7.17.46.3-6.6-7.16.7-6.6
Time to tail flick, vehicle, before self-admin1.21.22.2-1.51.51.5-1.21.11.30.9-0.9-0.71.50.8-0.3-0.3
Time to tail flick, vehicle, after self-admin0.80.91.90.9-0.9-0.91.0-1.1-1.1-1.41.30.9-0.9-0.50.2-0.2
Time to tail flick, test, before self-admin1.00.92.3-1.01.01.0-0.90.91.21.5-0.9-0.91.00.8-0.60.5
Time to tail flick, test, after self-admin1.21.32.5-1.01.01.0-0.91.01.21.2-1.2-1.61.11.1-1.21.3
Delta time to tail flick, vehicle, before/after SA1.01.01.41.2-1.2-1.21.1-1.1-1.1-1.11.10.6-1.2-0.3-0.30.5
Delta time to tail flick, test, before/after SA0.30.20.40.6-0.6-0.60.5-0.5-0.5-0.60.20.0-0.6-0.0-0.40.5
Tibia length0.20.51.10.7-0.7-0.70.9-0.8-0.9-0.80.81.1-0.7-0.1-0.40.3
Ambulatory time before self-admin0.20.30.7-0.40.40.4-0.60.60.50.3-0.2-0.80.20.6-0.60.5
Ambulatory time after self-admin2.32.53.61.7-1.7-1.71.7-1.7-1.9-1.81.81.0-1.8-1.41.0-0.5
Bone: tissue strength0.90.91.5-0.80.80.8-0.90.90.90.8-0.8-0.90.81.1-1.21.2
Total heroin consumption0.70.82.40.5-0.5-0.50.6-0.5-0.8-0.60.91.0-0.6-1.21.5-1.6
Bone: trabecular number0.81.31.9-1.21.21.2-1.11.11.11.4-1.2-1.31.01.0-0.91.1
Bone: trabecular spacing0.10.10.2-0.20.20.2-0.40.40.30.0-0.4-0.00.20.3-0.2-0.0
Bone: trabecular thickness0.60.71.21.0-1.0-1.00.9-0.9-1.1-0.80.40.7-1.0-0.60.10.2
Bone: trabecular tissue density10.214.418.04.2-4.2-4.24.0-4.0-4.2-4.03.73.4-4.1-3.62.9-2.4
Water consumed over 24 hours0.10.10.6-0.20.20.2-0.10.10.10.0-0.2-0.10.50.5-0.70.6
Number of responses in last shaping day0.10.10.70.2-0.2-0.20.2-0.1-0.2-0.80.20.4-0.1-0.0-0.00.3