Khdc3

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	gene expression	Khdc3	0.06	0.03	1.7e-05	0.04	0.05	0.03	0.04	1.6e-05	5.1e-06	5.5e-04	2.8e-05
2	Brain	gene expression	Khdc3	0.04	0.03	4.8e-05	0.04	0.04	0.03	0.04	1.2e-04	1.7e-04	3.4e-04	2.3e-04
3	IC	gene expression	Khdc3	0.07	0.04	1.2e-03	0.05	0.07	0.07	0.07	2.6e-03	5.3e-04	9.6e-04	9.7e-04
4	BLA	gene expression	Khdc3	0.12	0.07	5.9e-06	0.08	0.09	0.07	0.09	6.3e-05	2.4e-05	1.7e-04	2.4e-05
5	PL	gene expression	Khdc3	0.1	0.05	3.6e-10	0.08	0.09	0.07	0.09	5.6e-09	3.2e-10	6.6e-08	2.4e-10

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5
Bone: apparent density	0.3	0.5	0.9	-0.9	0.7	-0.4	-0.8	-0.5
Area under the delay curve	0.1	0.1	0.4	-0.1	0.2	0.6	-0.0	-0.2
BMI with tail	6.6	22.9	32.6	3.8	-4.7	5.7	4.7	4.8
BMI without tail	1.0	5.1	8.3	1.1	-2.3	2.6	1.9	2.9
Body weight	3.4	14.8	24.3	3.1	-3.8	4.9	3.8	3.4
Weight adjusted by age	2.3	6.7	8.2	2.4	-2.9	2.2	2.8	2.6
Bone surface	0.0	0.1	0.2	-0.1	-0.3	0.3	0.2	0.5
Bone volume	0.1	0.1	0.2	-0.1	-0.4	0.5	0.2	0.4
Breakpoint value in progressive ratio session	0.0	0.0	0.1	-0.3	0.3	0.2	-0.1	0.1
Number of licking bursts	0.9	2.8	4.6	-1.4	1.5	-2.2	-1.8	-1.4
Context. condit. distance diff. score	0.1	0.1	0.3	0.2	-0.1	0.2	-0.1	-0.6
Locomotion velocity, session 1	0.9	1.0	2.6	0.9	-0.6	0.6	0.9	1.6
Locomotion distance, session 1	0.4	0.5	0.7	-0.8	0.7	-0.8	-0.8	-0.1
Locomotion velocity, session 2	0.2	0.3	0.7	-0.8	0.5	-0.1	-0.5	0.3
Locomotion distance, session 2	0.2	0.4	1.0	-1.0	0.2	-0.1	-0.4	0.7
Locomotion velocity, session 3	0.5	0.5	1.0	-1.0	0.4	-1.0	-0.5	0.6
Locomotion distance, session 3	3.2	3.7	4.9	-2.2	2.0	-2.1	-2.0	-1.3
Stereotopy head waving bouts, day 3	1.6	1.9	3.6	1.9	-1.4	1.0	1.4	0.9
Stereotopy head waving duration, day 3	2.5	3.1	5.1	2.3	-1.8	1.4	1.8	1.4
Locomotion velocity, session 7	0.7	0.8	0.9	-0.9	0.7	-0.9	-0.9	-0.9
Locomotion distance, session 7	1.6	2.1	2.9	-1.7	1.5	-1.6	-1.4	-0.9
Stereotopy head waving bouts, day 7	0.7	0.8	1.9	0.7	-0.8	0.7	0.7	1.4
Stereotopy head waving duration, day 7	0.7	0.9	2.2	0.7	-0.9	0.5	0.7	1.5
Locomotion velocity, session 8	0.1	0.2	0.6	-0.4	-0.2	-0.0	0.1	0.8
Locomotion distance, session 8	0.7	1.0	2.2	-1.5	0.9	-0.8	-1.1	-0.3
Degree of sensitization distance	0.0	0.0	0.0	-0.1	0.2	-0.2	-0.1	-0.1
Degree of sensitization stereotypy	0.5	0.5	1.6	0.4	-0.6	0.5	0.4	1.3
Conditioned locomotion	0.3	0.3	1.3	0.0	-0.4	1.2	0.2	-0.3
Cocaine response after cond. corrected	4.4	6.6	8.3	2.9	-2.6	2.4	2.6	2.3
Cocaine response after cond. not corrected	3.8	5.5	8.1	2.8	-2.4	2.1	2.3	1.9
Cocaine response before conditioning	0.7	0.8	1.3	-0.8	0.8	-0.7	-1.0	-1.1
Saline control response	0.1	0.2	0.3	0.5	-0.3	-0.3	0.1	0.6
Bone: connectivity density	2.1	3.4	4.9	-2.2	1.8	-1.9	-2.0	-1.0
Bone: cortical apparent density	0.6	0.9	1.3	-0.4	0.9	-1.1	-1.1	-1.1
Bone: cortical area	1.0	1.7	3.6	1.9	-1.3	1.3	1.2	0.3
Bone: cortical porosity	0.7	0.7	1.5	-0.6	1.0	-0.6	-0.7	-1.2
Bone: cortical porosity	1.0	1.1	2.6	-0.8	1.0	-0.6	-0.9	-1.6
Bone: cortical thickness	0.2	0.4	1.1	0.6	0.3	-0.2	-0.3	-1.1
Bone: cortical thickness	0.2	0.2	0.5	0.7	-0.3	0.0	0.3	-0.6
Bone: cortical tissue density	0.6	1.0	1.4	-0.5	1.0	-1.2	-1.1	-1.1
Condit. Reinf. active minus inactive responses	1.5	1.7	3.5	-1.9	1.2	-0.5	-1.2	-1.2
Condit. Reinf. active-inactive response ratio	0.4	0.5	2.1	0.1	0.3	0.1	-0.3	-1.4
Condit. Reinf. active responses	1.4	1.8	5.3	-2.3	1.2	-0.7	-1.2	-0.4
Condit. Reinf. inactive responses	1.3	1.7	4.8	-2.2	1.0	-1.1	-1.0	0.9
Incentive salience index mean	0.9	1.1	2.5	-1.6	1.0	-0.1	-0.9	-1.1
Condit. Reinf. lever presses	0.4	0.6	1.4	-1.2	0.7	0.1	-0.6	-0.8
Condit. Reinf. active minus inactive responses	1.2	1.8	2.2	0.8	-1.5	1.4	1.5	1.4
Condit. Reinf. active-inactive response ratio	1.3	2.1	2.5	1.5	-1.5	1.5	1.6	1.1
Condit. Reinf. active responses	0.6	0.9	1.4	0.3	-1.0	1.2	1.0	0.9
Condit. Reinf. inactive responses	0.6	1.0	2.4	-1.5	0.9	-0.7	-0.9	-0.5
Condit. Reinf. lever presses	0.1	0.2	0.8	0.4	0.1	-0.1	0.0	-0.9
Condit. Reinf. lever reinforcers received	0.5	0.6	1.2	0.2	-0.9	1.1	0.8	0.7
Conditioned reinforcement - actives	0.1	0.3	0.6	0.7	-0.7	0.3	0.8	0.1
Conditioned reinforcement - inactives	0.1	0.3	0.8	0.9	-0.5	0.2	0.6	0.3
Conditioned locomotion	0.1	0.2	0.8	-0.1	0.1	0.2	0.2	-0.9
Patch foraging indifference point 0 sec	0.1	0.1	0.5	0.2	-0.3	0.2	0.3	0.7
Patch foraging indifference point AUC	1.3	3.0	6.1	-2.5	1.9	-1.3	-1.6	-1.0
Delay disc. indifference point, 0s delay	2.1	2.4	4.3	-2.1	1.8	-1.0	-1.5	-1.1
Delay disc. indifference point, 16s delay	0.1	0.2	0.5	0.2	0.2	0.6	-0.2	-0.7
Delay disc. indifference point, 2s delay	0.1	0.1	0.1	-0.2	0.2	-0.3	-0.3	-0.2
Delay disc. indifference point, 24s delay	0.1	0.1	0.3	-0.2	0.5	-0.0	-0.5	-0.4
Delay disc. indifference point, 4s delay	0.5	0.5	1.0	-0.7	0.8	0.0	-0.7	-1.0
Delay disc. indifference point, 8s delay	0.1	0.2	0.8	0.1	-0.2	0.9	0.4	0.4
Indifference point function ln k	1.6	4.8	8.2	2.9	-2.4	1.8	2.1	1.5
Indifference point function log k	1.6	4.8	8.2	2.9	-2.4	1.8	2.1	1.5
Patch foraging total patch changes 0 sec	0.1	0.2	0.7	0.4	-0.3	0.3	0.4	0.8
Patch foraging total patch changes 12 sec	1.1	1.5	2.4	-1.5	1.4	-1.1	-1.3	-0.5
Patch foraging total patch changes 18 sec	0.1	0.3	0.6	-0.5	0.8	-0.5	-0.5	-0.2
Patch foraging total patch changes 24 sec	0.4	1.2	2.0	-1.4	1.4	-1.1	-1.0	0.2
Patch foraging total patch changes 6 sec	0.8	1.4	3.5	-1.9	1.3	-0.8	-1.0	0.2
Patch foraging time to switch 0 sec	0.2	0.7	1.9	-0.5	0.7	-0.6	-0.7	-1.4
Patch foraging water rate 0 sec	0.7	2.6	3.7	1.6	-1.5	1.5	1.6	1.9
Patch foraging water rate 12 sec	1.1	4.5	9.2	2.0	-1.7	1.6	1.9	3.0
Patch foraging water rate 18 sec	0.2	0.5	1.2	0.7	-0.5	0.5	0.5	1.1
Patch foraging water rate 24 sec	0.2	0.3	0.7	-0.4	0.5	-0.8	-0.6	0.4
Patch foraging water rate 6 sec	0.4	0.6	1.4	0.7	-0.5	0.4	0.6	1.2
Seeking ratio, delayed vs. immediate footshock	1.1	1.6	2.4	0.8	-1.3	1.3	1.6	1.1
Distance traveled before self-admin	0.0	0.1	0.2	0.3	-0.1	0.0	0.4	-0.1
Distance traveled after self-admin	2.1	3.6	5.7	2.4	-2.1	1.4	2.0	1.5
Extensor digitorum longus weight	6.3	25.2	31.3	3.7	-5.2	5.6	5.1	5.3
Bone: elastic displacement	0.0	0.0	0.1	-0.1	-0.0	0.3	0.1	0.1
Bone: elastic work	0.1	0.1	0.3	0.1	-0.2	0.5	0.0	-0.5
Bone: endosteal estimation	2.3	5.7	6.9	2.3	-2.6	2.4	2.5	2.1
Bone: endosteal perimeter	2.7	6.5	8.7	2.0	-2.7	3.0	2.6	2.3
Epididymis fat weight	0.1	0.8	2.2	-1.5	0.6	-0.7	-0.9	0.1
Delta time in closed arm before/after self-admin	0.2	0.2	0.5	0.0	0.2	-0.2	-0.6	-0.7
Delta time in open arm before/after self-admin	0.3	0.4	1.3	-0.3	0.4	-1.2	-0.4	-0.1
Diff in mean of infusions in LGA sessions	0.6	1.1	2.7	0.6	-1.2	1.6	0.9	0.3
Delay discount exponential model param	0.1	0.1	0.3	0.0	-0.1	-0.6	-0.0	0.1
Extinction: sum of active levers before priming	0.0	0.1	0.2	-0.0	0.2	-0.4	0.1	0.3
Active lever presses in extinction session 6	0.5	0.5	0.7	0.4	-0.8	0.7	0.8	0.8
Bone: final force	0.8	1.3	1.9	1.3	-1.2	1.4	1.2	0.5
Bone: final moment	0.8	1.3	2.1	1.4	-1.1	1.3	1.1	0.2
Food consumed during 24 hour testing period	1.3	2.7	6.0	2.5	-1.6	1.0	1.6	1.2
Glucose	0.4	0.6	1.3	0.8	-1.0	0.3	0.5	1.2
Heart weight	0.3	0.4	0.7	-0.8	0.2	0.8	0.1	0.9
Delay discount hyperbolic model param	0.1	0.1	0.3	0.1	-0.2	-0.5	0.1	0.3
Intermittent access intake day 1-15 change	0.1	0.4	0.7	0.7	-0.9	0.0	0.4	0.7
Intermittent access intake escalation	0.1	0.5	1.0	0.7	-1.0	0.3	0.5	0.8
Intermittent access intake escalation 2	0.6	1.0	1.3	1.1	-1.2	1.0	0.9	0.8
Intermitt. access day 1 inactive lever presses	0.0	0.2	0.5	0.7	0.1	-0.3	-0.1	-0.7
Intermitt. access day 15 inactive lever presses	0.1	0.3	0.5	0.7	-0.1	0.6	0.4	0.6
Intermitt. access escalation Index	0.0	0.2	0.3	-0.5	0.4	0.6	-0.1	0.2
Intermittent access day 1 total infusions	0.3	0.8	1.7	-0.1	0.8	-1.2	-0.6	-1.3
Intermittent access day 15 total infusions	0.1	0.3	0.6	-0.0	0.2	-0.8	-0.3	-0.8
Intermittent access terminal intake (last 3 days)	0.1	0.2	0.5	0.5	-0.3	-0.2	0.1	-0.7
Intermittent access total infusions	0.2	0.2	0.5	0.5	0.0	-0.7	0.0	-0.6
Intermittent access day 1 locomotion	0.5	0.9	2.4	-0.1	0.5	-1.4	-0.5	-1.5
Intermittent access day 15 total locomotion	0.1	0.4	1.0	0.7	-0.2	-0.3	0.3	-1.0
Intermittent access total locomotion	0.4	0.4	1.1	1.0	-0.7	-0.0	0.7	-0.1
Intermittent access standard deviation	0.1	0.3	1.0	1.0	-0.6	0.1	0.5	0.1
Left kidney weight	1.2	9.4	10.6	3.2	-3.0	3.0	2.9	3.3
Right kidney weight	0.9	6.3	11.1	2.2	-2.3	2.3	2.3	3.3
Cocaine induced anxiety	0.0	0.1	0.5	-0.4	0.1	0.2	-0.1	-0.7
Post-drug Anxiety	1.7	2.0	2.7	-1.4	1.1	-1.7	-1.4	-1.4
Baseline Anxiety	1.1	1.8	4.7	-1.3	0.9	-2.2	-1.3	-0.4
Tail length	0.5	2.5	4.0	-1.8	1.3	-2.0	-1.7	-1.0
Length with tail	0.0	0.0	0.1	0.0	-0.3	0.1	0.1	0.2
Length without tail	1.4	7.5	11.4	2.7	-2.5	3.4	2.9	2.0
Times rat made contact with spout	0.1	0.1	0.4	0.6	0.2	-0.1	-0.1	-0.0
Lifetime Intake	0.1	0.2	0.5	0.3	0.1	-0.7	0.0	-0.6
Liver weight, left	2.3	3.9	6.7	1.6	-2.0	1.9	1.7	2.6
Liver weight, right	1.6	2.8	4.0	1.4	-2.0	1.5	1.5	1.9
Locomotor activity	5.0	7.8	8.8	2.5	-2.8	3.0	3.0	2.6
Locomotor testing distance	2.6	6.3	6.7	2.5	-2.5	2.5	2.6	2.5
Locomotor testing rearing	0.4	1.5	2.2	1.0	-1.4	1.1	1.2	1.5
Locomotion in novel chamber	0.2	0.3	0.8	0.9	-0.6	0.2	0.1	-0.4
Locomotion in novel chamber post-restriction	0.2	0.6	0.9	-1.0	0.9	-0.3	-0.9	-0.8
Fecal boli incidents, locomotor time 1	0.4	1.0	1.5	-1.2	1.1	-0.5	-0.9	-1.0
Change in fecal boli incidents, locomotor task	3.1	3.3	7.1	2.7	-1.9	1.1	1.7	1.3
Time >=10cm from walls, locomotor time 1	0.6	0.8	1.3	0.7	-1.1	1.1	0.8	0.5
Bouts of movement, locomotor time 1	0.0	0.0	0.2	0.1	0.0	0.4	0.2	0.2
Total resting periods, locomotor time 1	0.0	0.0	0.1	0.2	0.0	0.2	0.1	0.1
Rest time, locomotor task time 1	0.1	0.2	0.8	0.4	-0.0	0.4	-0.1	-0.9
Distance moved, locomotor task time 1	0.2	0.5	1.2	-1.1	0.5	-0.8	-0.6	0.2
Vertical activity count, locomotor time 1	0.1	0.4	1.1	-1.0	0.6	-0.5	-0.4	-0.3
Time >=10cm from walls, locomotor time 2	0.0	0.1	0.2	0.3	-0.1	0.5	0.2	0.1
Bouts of movement, locomotor time 2	0.1	0.4	1.4	-0.1	-0.2	0.5	0.4	1.2
Total resting periods, locomotor time 2	0.1	0.4	1.6	0.1	-0.2	0.5	0.5	1.3
Rest time, locomotor task time 2	0.1	0.2	0.6	0.5	-0.0	-0.2	-0.2	-0.8
Distance moved, locomotor task time 2	0.4	0.5	1.4	-1.2	0.3	-0.7	-0.4	0.5
Vertical activity count, locomotor time 2	0.5	1.2	1.9	-1.4	1.1	-1.4	-0.8	-0.6
Light reinforcement 1	0.7	3.0	5.7	0.9	-1.5	2.4	1.7	1.8
Light reinforcement 2	0.2	0.4	1.4	1.2	-0.3	0.1	0.0	-0.8
Bone: marrow area	2.5	6.1	7.5	2.4	-2.7	2.4	2.6	2.1
Bone: maximum diameter	3.3	6.6	7.5	2.7	-2.6	2.7	2.7	2.1
Bone: maximum force	0.7	1.3	2.1	1.2	-1.2	1.4	1.1	0.5
Bone: maximum moment	0.7	1.3	2.0	1.4	-1.2	1.4	1.1	0.3
Mean time between licks in bursts	0.1	0.6	1.2	-0.4	0.5	-0.9	-0.7	-1.1
Mean num. licks in bursts	1.2	3.4	4.5	2.1	-1.5	2.1	1.9	1.5
Cd content in liver	4.0	4.5	8.5	-2.9	2.4	-1.3	-2.2	-1.3
Co content in liver	1.4	1.7	2.5	-1.4	1.5	-0.3	-1.2	-1.6
Cu content in liver	0.1	0.1	0.4	0.3	-0.4	0.6	0.3	-0.1
Fe content in liver	0.1	0.2	0.8	0.1	-0.1	0.1	0.2	0.9
K content in liver	0.4	0.4	0.8	0.2	-0.4	0.7	0.7	0.9
Mg content in liver	0.6	0.6	0.8	0.6	-0.7	0.8	0.9	0.9
Mn content in liver	1.1	1.2	2.5	1.6	-1.0	1.2	1.0	0.1
Na content in liver	3.0	3.4	5.0	1.3	-1.8	1.9	2.0	2.2
Rb content in liver	0.7	0.8	1.8	0.6	-0.8	0.7	0.9	1.3
Se content in liver	0.1	0.2	0.5	-0.1	0.4	-0.7	-0.4	0.1
Sr content in liver	1.6	1.4	2.3	-1.5	1.2	-1.0	-1.2	-0.9
Zn content in liver	0.1	0.1	0.2	-0.1	-0.0	0.5	0.0	-0.2
Bone: minimum diameter	0.5	0.9	1.9	1.1	-0.9	1.4	0.7	-0.3
Time in familiar zone, hab. session 1	0.1	0.1	0.2	-0.2	0.3	0.5	-0.1	-0.3
Time in novel zone, hab. session 1	0.1	0.1	0.3	0.1	-0.1	-0.6	-0.1	-0.1
Total zone transitions, hab. session 1	1.3	1.8	3.0	-1.7	1.4	-1.2	-1.6	0.0
Total locomotion distance, hab. session 1	0.6	0.9	1.7	-1.3	0.9	-0.9	-1.0	0.3
Locomotion velocity, hab. session 1	0.3	0.4	0.6	-0.8	0.5	-0.5	-0.5	0.5
Time in familiar zone, hab. session 2	0.2	0.2	0.5	-0.4	0.6	-0.7	-0.5	-0.1
Time in novel zone, hab. session 2	0.7	0.8	1.3	1.2	-0.9	0.9	0.9	0.2
Total zone transitions, hab. session 2	0.7	0.9	3.2	-1.8	0.7	-0.3	-0.9	0.2
Total locomotion distance, hab. session 2	0.5	0.7	2.4	-1.5	0.5	0.0	-0.7	0.4
Locomotion velocity, hab. session 2	0.4	0.6	2.0	-1.4	0.5	0.0	-0.7	0.2
Novel to familiar place preference ratio	0.9	1.1	2.0	0.7	-1.2	1.4	1.0	0.7
Novelty place preference	1.1	1.4	2.5	0.9	-1.3	1.6	1.2	0.8
Time in novel zone, NPP test	1.7	2.1	3.0	1.3	-1.6	1.7	1.4	1.0
Total zone transitions, NPP test	0.3	0.4	0.9	-1.0	0.7	-0.1	-0.7	0.5
Total locomotion distance, NPP test	0.3	0.4	1.0	-1.0	0.5	-0.2	-0.4	0.9
Locomotion velocity, NPP test	0.7	1.1	2.6	-1.6	1.0	-0.7	-0.9	0.6
Intraocular pressure	0.2	0.3	0.5	-0.7	0.7	-0.5	-0.5	-0.3
Delta distance traveled before/after self-admin	4.4	4.8	7.3	2.7	-2.5	1.7	2.1	1.8
Delta ambulatory time before/after self-admin	2.2	3.8	6.7	2.6	-2.1	1.6	1.8	1.4
Parametrial fat weight	2.1	4.9	6.2	-2.2	2.5	-2.4	-2.1	-1.8
Pavlov. Cond. lever latency	0.8	1.0	2.9	1.7	-1.2	0.2	0.8	0.4
Pavlov. Cond. magazine entry latency	4.4	5.7	9.4	-3.1	2.6	-0.8	-2.2	-2.6
Pavlov. Cond. change in total contacts	1.1	1.2	2.6	-1.6	1.1	-0.0	-0.8	-1.2
Pavlov. Cond. index score	3.7	4.6	8.6	-2.9	2.3	-1.0	-2.0	-2.0
Pavlov. Cond. latency score	3.0	3.8	7.6	-2.7	2.2	-1.0	-1.8	-1.7
Pavlov. Cond. lever contacts	1.1	1.3	3.1	-1.8	1.3	-0.2	-1.0	-0.9
Pavlov. Cond. magazine entry number	4.3	5.5	9.0	3.0	-2.5	0.9	2.1	2.6
Pavlov. Cond. intertrial magazine entries	0.3	0.4	0.8	-0.5	0.1	-0.8	-0.2	0.9
Pavlov. Cond. lever-magazine prob. diff.	3.3	4.1	8.1	-2.8	2.2	-0.9	-1.8	-1.9
Pavlov. Cond. response bias	3.0	3.7	6.8	-2.6	2.1	-0.4	-1.7	-2.1
Pavlov. Cond. lever latency	0.4	0.6	1.1	0.9	-0.8	0.4	0.6	1.0
Pavlov. Cond. magazine entry latency	3.4	4.8	6.1	-1.7	2.5	-2.1	-2.2	-2.3
Pavlov. Cond. change in total contacts	0.7	1.7	1.8	-1.3	1.4	-1.1	-1.4	-1.3
Pavlov. Cond. index score	1.4	2.1	2.5	-1.4	1.6	-1.3	-1.4	-1.6
Pavlov. Cond. latency score	0.9	1.4	1.8	-1.0	1.3	-1.0	-1.2	-1.3
Pavlov. Cond. lever contacts	0.4	0.5	1.0	-0.8	0.7	-0.4	-0.5	-1.0
Pavlov. Cond. magazine entry number	3.3	4.3	5.0	1.7	-2.2	2.1	2.1	2.1
Pavlov. Cond. intertrial magazine entries	0.4	0.9	1.8	0.7	-1.0	0.6	0.9	1.3
Pavlov. Cond. lever-magazine prob. diff.	1.7	2.6	3.0	-1.6	1.7	-1.5	-1.5	-1.7
Pavlov. Cond. response bias	2.2	3.1	3.9	-1.9	1.9	-1.3	-1.7	-2.0
Time in closed arm before self-admin	0.1	0.2	0.4	-0.5	0.6	0.1	-0.3	-0.4
Time in closed arm after self-admin	0.2	0.2	0.3	-0.5	0.5	-0.3	-0.5	-0.5
Time in open arm before self-admin	1.2	1.4	2.1	1.4	-1.1	1.3	1.2	0.7
Time in open arm after self-admin	0.7	0.8	1.4	1.2	-1.0	0.6	1.0	0.6
Bone: periosteal estimation	2.4	5.7	6.9	2.6	-2.6	2.4	2.5	1.7
Bone: periosteal perimeter	2.8	5.5	7.0	2.3	-2.6	2.4	2.4	1.8
Bone: post-yield work	0.0	0.1	0.1	-0.1	-0.3	0.3	0.2	0.4
Progressive ratio test 1 active lever presses	0.1	0.1	0.5	-0.0	0.2	-0.7	-0.0	-0.4
Progressive ratio test 1 breakpoint	0.1	0.2	0.6	-0.1	0.3	-0.8	-0.1	-0.4
Progressive ratio test 1 inactive lever presses	0.5	1.2	4.2	0.0	0.6	-2.1	-0.6	-1.1
Progressive ratio test 2 active lever presses	0.4	0.6	1.1	0.8	-0.6	0.6	1.1	0.6
Progressive ratio test 2 breakpoint	0.4	0.5	0.9	0.7	-0.6	0.5	1.0	0.6
Progressive ratio test 2 inactive lever presses	0.1	0.2	0.8	0.9	0.1	-0.1	0.5	-0.3
Incentive Sensitization - Responses	0.5	1.4	2.5	1.0	-0.9	1.6	1.4	1.0
Incentive Sensitization - Breakpoint	0.5	1.1	2.2	0.8	-0.7	1.5	1.2	0.9
Sum of active levers in priming session hrs 5-6	0.2	0.2	0.4	0.6	-0.5	0.1	0.3	0.3
Progressive ratio	0.3	0.7	2.0	-1.0	0.5	-0.0	-0.7	-1.4
Food seeking constrained by brief footshock	0.3	0.4	1.2	0.2	-0.6	-0.1	0.4	1.1
Seeking ratio, punishment vs. effort	1.5	3.4	8.1	1.5	-1.6	0.9	1.8	2.8
Retroperitoneal fat weight	0.7	3.0	4.5	-1.8	2.1	-1.9	-1.8	-0.4
Reaction time number correct	0.4	1.5	2.7	0.7	-1.3	1.0	1.2	1.7
Reaction time mean minus median	0.1	0.4	1.0	-0.5	0.4	-1.0	-0.6	-0.4
Reaction time mean minus median AUC	0.1	0.9	2.2	-0.6	0.8	-1.5	-1.0	-0.6
Reaction time num false alarms	0.2	0.4	0.9	-0.5	0.5	-1.0	-0.6	-0.2
Reaction time num false alarms AUC	0.1	0.2	0.6	-0.2	0.3	-0.8	-0.2	0.4
Reaction time trials correct on left	0.4	1.5	2.7	0.7	-1.3	1.0	1.2	1.7
Reaction time trials on left	0.4	1.4	2.8	0.6	-1.2	0.9	1.2	1.7
Reaction time mean	1.2	2.6	3.7	-0.9	1.6	-1.9	-1.4	-1.9
Reaction time mean AUC	1.0	2.4	3.6	-0.9	1.5	-1.9	-1.4	-1.9
Median of all reaction times	2.2	3.5	5.7	-1.1	1.9	-2.1	-1.6	-2.4
Reaction time omissions	0.2	0.3	0.6	-0.6	0.6	-0.8	-0.4	0.1
Reaction time false alarm rate	0.6	0.9	1.6	-0.6	1.0	-1.3	-1.0	-0.7
Reaction time premature initiation rate	0.5	0.8	1.1	0.6	-1.0	0.5	1.1	1.0
Reaction time premature initiations	0.6	1.9	2.9	0.9	-1.6	1.0	1.6	1.7
Std. dev. reaction times	0.6	1.9	3.3	-1.1	1.4	-1.8	-1.3	-1.2
Reaction time trials completed	0.4	1.4	2.8	0.6	-1.2	0.9	1.2	1.7
Reaction time trials AUC	0.3	1.2	2.4	0.5	-1.1	0.9	1.1	1.6
Run reversals in cocaine runway, females	0.2	0.2	0.4	0.6	-0.4	-0.2	0.2	0.5
Run reversals in cocaine runway, males	0.3	0.4	1.0	-1.0	0.5	-0.3	-0.2	0.7
Latency to leave start box in cocaine runway	1.1	1.5	1.8	1.0	-1.3	1.2	1.3	1.3
Latency to leave start box in cocaine runway, F	0.3	0.3	0.8	0.3	-0.6	0.1	0.6	0.9
Latency to leave start box in cocaine runway, M	4.3	4.1	5.9	1.9	-1.9	2.4	2.1	1.8
Std. dev. time between licks in bursts	0.1	0.1	0.5	-0.7	0.0	0.1	-0.2	-0.2
Total sessions with >9 infusions	0.2	0.3	1.3	0.2	0.0	-1.1	0.0	-0.2
Short access day 1 total inactive lever presses	0.2	0.5	2.0	1.4	-0.5	-0.1	0.4	0.1
Short access day 10 total inactive lever presses	0.0	0.2	0.6	0.2	0.7	-0.8	-0.3	-0.3
Short access day 1 total infusions	0.2	0.3	0.5	0.7	-0.7	-0.3	0.7	-0.1
Short access day 10 total infusions	0.7	1.1	2.0	-0.4	0.8	-1.4	-0.7	-1.4
Short access total infusions	0.4	0.6	1.8	-0.2	0.4	-1.3	-0.4	-0.9
Short access day 1 locomotion	0.1	0.1	0.3	0.3	-0.3	0.2	0.5	-0.2
Short access day 10 total locomotion	0.1	0.6	1.5	1.2	-0.9	-0.4	0.6	-0.2
Short access total locomotion	0.2	0.2	0.5	0.6	-0.1	-0.7	0.2	-0.6
One hour access (0.3 mA shock)	0.8	0.9	1.4	1.2	-0.9	1.2	0.9	0.4
Compulsive drug intake	0.8	1.2	2.2	1.5	-1.0	0.9	0.7	1.2
One hour access (shock baseline)	0.1	0.2	0.5	-0.3	0.5	-0.1	-0.1	-0.7
Social response proportion	1.1	1.4	2.0	1.3	-1.3	1.4	1.3	0.1
Social responses	0.1	0.1	0.2	0.1	-0.2	0.4	0.3	0.3
Social time	0.4	0.6	1.1	1.1	-0.7	0.4	0.8	0.7
Soleus weight	13.7	40.3	45.2	5.0	-6.5	6.7	6.7	6.6
Bone: stiffness	0.8	1.4	2.1	1.1	-1.3	0.7	1.2	1.5
Tibialis anterior weight	13.6	46.8	52.2	6.2	-7.2	6.6	7.2	6.9
Time to tail flick, vehicle, before self-admin	1.6	2.0	4.7	-2.2	1.3	-1.1	-1.3	-0.8
Time to tail flick, vehicle, after self-admin	0.3	0.6	1.8	1.3	-0.7	0.3	0.8	-0.1
Time to tail flick, test, before self-admin	2.0	2.3	4.0	-2.0	1.5	-0.6	-1.3	-1.8
Time to tail flick, test, after self-admin	1.9	2.0	2.5	-1.4	1.4	-1.6	-1.3	-1.3
Delta time to tail flick, vehicle, before/after SA	0.9	1.0	3.1	1.8	-0.9	0.5	0.9	0.0
Delta time to tail flick, test, before/after SA	0.6	0.7	2.3	1.5	-0.7	0.1	0.8	0.5
Tibia length	0.5	1.5	3.0	1.7	-1.1	1.4	1.0	-0.6
Ambulatory time before self-admin	0.1	0.3	0.4	-0.3	0.6	-0.7	-0.2	-0.6
Ambulatory time after self-admin	2.0	3.2	6.2	2.5	-1.9	1.2	1.9	1.2
Bone: tissue strength	0.4	0.4	0.8	-0.0	0.6	-0.6	-0.7	-0.9
Total heroin consumption	0.3	0.3	0.8	-0.1	-0.4	0.5	0.5	0.9
Bone: trabecular number	1.4	2.5	4.1	-2.0	1.6	-1.3	-1.7	-1.1
Bone: trabecular spacing	0.0	0.0	0.0	0.0	-0.0	0.0	-0.0	0.1
Bone: trabecular thickness	0.2	0.2	0.7	0.8	-0.4	0.4	0.4	0.1
Bone: trabecular tissue density	7.1	12.4	15.9	4.0	-3.7	3.4	3.6	2.9
Water consumed over 24 hours	0.1	0.1	0.3	0.3	0.2	-0.2	-0.2	-0.6
Number of responses in last shaping day	0.3	0.3	0.6	0.8	-0.7	0.3	0.6	0.3