Ubap1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	PL	gene expression	Ubap1	0.04	0.03	8.3e-04	0.02	0.02	0.02	0.02	1.8e-03	1.8e-03	1.9e-03	2.1e-03
2	Adipose	mRNA stability	Ubap1	0.06	0.05	1.1e-04	0.02	0.03	0.02	0.03	1.1e-03	4.1e-04	1.1e-03	5.0e-04
3	NAcc	gene expression	Ubap1	0.05	0.03	2.6e-05	0.04	0.02	0.03	0.02	4.2e-06	5.4e-04	1.7e-05	7.6e-04
4	Liver	gene expression	Ubap1	0.12	0.07	3.6e-13	0.11	0.12	0.11	0.11	2.6e-12	7.2e-13	4.8e-12	2.6e-12
5	Adipose	gene expression	Ubap1	0.21	0.1	0.0e+00	0.19	0.19	0.2	0.19	2.2e-20	3.2e-20	1.6e-21	8.0e-21

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5
Bone: apparent density	1.3	2.3	2.8	1.4	1.4	1.5	-1.7	-1.5
Area under the delay curve	1.0	1.1	1.3	-1.0	-1.0	-1.1	1.1	1.1
BMI with tail	1.3	4.6	5.2	2.3	2.3	2.2	-2.1	-1.9
BMI without tail	1.7	5.1	6.1	2.5	2.5	2.3	-2.1	-2.0
Body weight	2.1	9.3	13.1	3.6	3.6	3.1	-2.3	-2.4
Weight adjusted by age	0.1	0.1	0.3	0.1	0.1	0.0	0.6	0.3
Bone surface	0.5	1.0	1.3	1.1	1.1	1.0	-0.9	-0.8
Bone volume	0.6	1.1	1.2	1.1	1.1	1.0	-1.1	-0.9
Breakpoint value in progressive ratio session	2.7	3.2	5.8	-1.2	-1.2	-1.7	2.4	2.2
Number of licking bursts	4.7	7.6	8.5	2.9	2.9	2.8	-2.7	-2.5
Context. condit. distance diff. score	0.1	0.1	0.1	-0.4	-0.3	-0.3	0.1	0.1
Locomotion velocity, session 1	1.0	1.1	3.6	0.2	0.0	-0.7	1.9	1.1
Locomotion distance, session 1	0.2	0.3	0.9	0.3	0.2	-0.4	1.0	0.5
Locomotion velocity, session 2	2.0	2.4	2.5	1.6	1.6	1.5	-1.5	-1.5
Locomotion distance, session 2	1.1	1.5	2.8	1.7	1.6	1.1	-0.5	-0.8
Locomotion velocity, session 3	0.2	0.2	0.6	0.1	0.1	-0.3	0.8	0.4
Locomotion distance, session 3	0.9	1.0	1.9	1.4	1.3	0.9	-0.4	-0.6
Stereotopy head waving bouts, day 3	0.1	0.1	0.4	-0.0	-0.0	0.1	0.6	0.3
Stereotopy head waving duration, day 3	0.0	0.0	0.1	-0.2	-0.1	0.2	0.2	0.1
Locomotion velocity, session 7	0.1	0.1	0.1	-0.2	-0.2	-0.3	0.2	0.2
Locomotion distance, session 7	0.1	0.1	0.2	0.5	0.5	0.2	0.0	-0.0
Stereotopy head waving bouts, day 7	1.2	1.4	1.7	1.3	1.3	1.3	-0.8	-1.0
Stereotopy head waving duration, day 7	0.8	1.0	1.3	1.0	1.0	1.1	-0.8	-1.0
Locomotion velocity, session 8	0.2	0.3	0.8	0.0	-0.1	-0.5	0.9	0.5
Locomotion distance, session 8	0.1	0.1	0.2	0.4	0.3	-0.1	0.5	0.2
Degree of sensitization distance	0.5	0.5	0.8	-0.9	-0.9	-0.6	0.5	0.6
Degree of sensitization stereotypy	1.4	1.5	1.7	1.3	1.3	1.3	-1.1	-1.1
Conditioned locomotion	0.2	0.2	0.6	-0.1	-0.1	-0.4	0.8	0.6
Cocaine response after cond. corrected	2.0	2.4	3.9	-1.3	-1.3	-1.5	2.0	1.5
Cocaine response after cond. not corrected	1.9	2.2	4.1	-1.1	-1.2	-1.4	2.0	1.5
Cocaine response before conditioning	0.8	1.0	1.1	1.0	1.0	1.0	-0.9	-0.9
Saline control response	0.7	0.9	1.7	1.3	1.2	1.0	-0.3	-0.6
Bone: connectivity density	0.5	0.8	1.4	0.8	0.8	0.8	-1.2	-0.9
Bone: cortical apparent density	0.2	0.3	0.8	0.1	0.2	0.3	-0.9	-0.7
Bone: cortical area	3.5	5.4	6.4	2.2	2.3	2.3	-2.5	-2.2
Bone: cortical porosity	0.1	0.1	0.2	-0.4	-0.4	-0.1	0.1	0.2
Bone: cortical porosity	0.0	0.0	0.0	0.1	0.1	0.2	-0.1	-0.1
Bone: cortical thickness	1.9	3.1	5.0	1.4	1.4	1.7	-2.2	-1.9
Bone: cortical thickness	0.1	0.1	0.2	-0.3	-0.3	-0.0	-0.5	-0.2
Bone: cortical tissue density	0.1	0.2	0.5	0.0	0.1	0.2	-0.7	-0.6
Condit. Reinf. active minus inactive responses	0.5	0.5	0.6	0.8	0.8	0.8	-0.6	-0.7
Condit. Reinf. active-inactive response ratio	0.5	0.5	0.7	-0.9	-0.8	-0.7	0.5	0.6
Condit. Reinf. active responses	2.6	3.3	3.8	2.0	1.9	1.8	-1.6	-1.7
Condit. Reinf. inactive responses	3.3	4.0	4.4	2.1	2.1	2.0	-1.9	-1.9
Incentive salience index mean	3.5	4.3	5.8	2.4	2.4	2.1	-1.6	-1.8
Condit. Reinf. lever presses	7.4	10.3	15.0	3.9	3.8	3.2	-2.2	-2.6
Condit. Reinf. active minus inactive responses	0.6	0.8	0.9	0.9	0.9	0.8	-1.0	-0.8
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.2	0.1	0.2	0.1	-0.5	-0.3
Condit. Reinf. active responses	1.9	2.7	3.3	1.8	1.8	1.6	-1.6	-1.4
Condit. Reinf. inactive responses	3.6	4.6	5.1	2.2	2.2	2.2	-2.2	-1.9
Condit. Reinf. lever presses	3.6	5.0	5.9	2.1	2.2	2.2	-2.4	-2.2
Condit. Reinf. lever reinforcers received	2.3	3.2	3.9	2.0	2.0	1.7	-1.7	-1.5
Conditioned reinforcement - actives	0.4	0.7	1.1	0.8	0.8	1.1	-0.8	-0.7
Conditioned reinforcement - inactives	0.1	0.1	0.3	0.3	0.3	0.6	-0.2	-0.1
Conditioned locomotion	0.1	0.2	0.3	0.5	0.5	0.5	-0.2	-0.2
Patch foraging indifference point 0 sec	0.4	0.8	2.2	0.2	0.1	-0.5	1.5	1.1
Patch foraging indifference point AUC	4.8	7.0	9.2	3.0	3.0	2.6	-2.1	-2.3
Delay disc. indifference point, 0s delay	1.3	1.4	1.6	-1.1	-1.1	-1.2	1.2	1.3
Delay disc. indifference point, 16s delay	1.9	2.0	3.0	-1.1	-1.2	-1.3	1.7	1.7
Delay disc. indifference point, 2s delay	0.3	0.4	0.6	0.4	0.4	0.6	-0.8	-0.6
Delay disc. indifference point, 24s delay	0.3	0.3	0.4	-0.6	-0.6	-0.5	0.5	0.6
Delay disc. indifference point, 4s delay	0.1	0.2	0.2	-0.4	-0.4	-0.5	0.3	0.3
Delay disc. indifference point, 8s delay	0.0	0.0	0.1	-0.1	-0.1	-0.2	0.1	0.2
Indifference point function ln k	1.6	2.9	3.4	-1.8	-1.8	-1.7	1.5	1.5
Indifference point function log k	1.6	2.9	3.4	-1.8	-1.8	-1.7	1.5	1.5
Patch foraging total patch changes 0 sec	0.2	0.4	1.0	0.7	0.5	-0.0	1.0	0.6
Patch foraging total patch changes 12 sec	1.3	1.7	2.3	1.5	1.5	1.3	-1.0	-1.1
Patch foraging total patch changes 18 sec	0.1	0.2	0.5	0.7	0.7	0.3	-0.0	0.0
Patch foraging total patch changes 24 sec	0.8	1.4	2.4	1.5	1.5	1.1	-0.6	-0.9
Patch foraging total patch changes 6 sec	0.9	1.4	2.9	1.7	1.6	1.1	-0.1	-0.5
Patch foraging time to switch 0 sec	0.9	1.9	3.1	-1.8	-1.7	-1.4	0.7	1.0
Patch foraging water rate 0 sec	0.4	0.9	1.8	1.3	1.3	0.9	-0.2	-0.5
Patch foraging water rate 12 sec	0.0	0.0	0.1	0.1	0.1	-0.0	0.3	0.0
Patch foraging water rate 18 sec	0.7	1.1	1.7	0.8	0.9	1.1	-1.3	-1.2
Patch foraging water rate 24 sec	0.1	0.1	0.4	-0.0	0.0	0.2	-0.7	-0.5
Patch foraging water rate 6 sec	1.2	1.7	2.1	1.4	1.4	1.3	-1.1	-1.2
Seeking ratio, delayed vs. immediate footshock	2.8	3.4	4.2	2.0	2.0	1.8	-1.6	-1.7
Distance traveled before self-admin	3.8	4.9	7.1	2.7	2.6	2.2	-1.6	-1.8
Distance traveled after self-admin	4.5	5.6	6.3	2.2	2.3	2.5	-2.4	-2.4
Extensor digitorum longus weight	4.8	19.0	23.0	4.8	4.8	4.6	-3.7	-3.8
Bone: elastic displacement	5.2	6.0	8.3	-2.9	-2.8	-2.5	1.7	2.0
Bone: elastic work	0.8	1.1	2.4	-1.6	-1.5	-0.9	-0.3	0.3
Bone: endosteal estimation	0.7	1.5	2.5	1.6	1.6	1.2	-0.6	-0.8
Bone: endosteal perimeter	0.6	1.3	2.3	1.5	1.5	1.1	-0.5	-0.7
Epididymis fat weight	0.2	0.7	0.9	0.9	0.9	0.8	-0.9	-0.6
Delta time in closed arm before/after self-admin	0.5	0.4	0.7	0.5	0.5	0.5	-0.9	-0.9
Delta time in open arm before/after self-admin	0.2	0.2	0.4	-0.4	-0.4	-0.4	0.6	0.6
Diff in mean of infusions in LGA sessions	0.1	0.1	0.3	0.0	0.0	0.3	-0.6	-0.3
Delay discount exponential model param	0.9	0.9	1.1	0.9	0.9	1.0	-1.0	-1.0
Extinction: sum of active levers before priming	2.2	2.4	2.8	-1.7	-1.7	-1.4	1.5	1.5
Active lever presses in extinction session 6	0.6	0.5	0.6	-0.8	-0.8	-0.7	0.7	0.8
Bone: final force	2.3	3.7	3.9	2.0	2.0	2.0	-1.8	-1.8
Bone: final moment	2.1	3.3	3.6	1.8	1.8	1.9	-1.8	-1.8
Food consumed during 24 hour testing period	0.5	0.7	1.3	1.1	1.1	0.8	-0.4	-0.5
Glucose	1.3	2.0	3.0	1.7	1.7	1.3	-1.1	-1.0
Heart weight	0.3	0.4	0.5	0.7	0.7	0.7	-0.6	-0.5
Delay discount hyperbolic model param	0.7	0.7	0.9	0.7	0.8	0.9	-0.9	-0.9
Intermittent access intake day 1-15 change	0.8	1.5	1.9	1.2	1.2	1.4	-1.2	-1.3
Intermittent access intake escalation	0.8	1.7	2.1	1.2	1.2	1.4	-1.3	-1.4
Intermittent access intake escalation 2	3.4	3.9	4.7	1.7	1.7	2.1	-2.1	-2.2
Intermitt. access day 1 inactive lever presses	0.1	0.4	0.9	0.9	0.9	0.5	-0.3	-0.3
Intermitt. access day 15 inactive lever presses	0.1	0.2	0.4	0.5	0.5	0.7	-0.3	-0.5
Intermitt. access escalation Index	0.1	0.2	0.3	0.5	0.5	0.4	-0.3	-0.2
Intermittent access day 1 total infusions	1.3	2.1	2.2	-1.4	-1.4	-1.4	1.5	1.5
Intermittent access day 15 total infusions	0.3	0.4	0.7	0.4	0.5	0.8	-0.7	-0.7
Intermittent access terminal intake (last 3 days)	0.9	1.2	1.8	1.0	1.1	1.3	-1.0	-1.1
Intermittent access total infusions	0.2	0.3	0.4	0.5	0.5	0.6	-0.4	-0.4
Intermittent access day 1 locomotion	1.9	2.4	2.6	-1.5	-1.5	-1.6	1.5	1.6
Intermittent access day 15 total locomotion	0.9	1.7	1.8	-1.3	-1.3	-1.3	1.3	1.3
Intermittent access total locomotion	0.6	0.7	1.2	-1.1	-1.1	-0.7	0.6	0.7
Intermittent access standard deviation	0.2	0.5	0.7	0.8	0.8	0.7	-0.5	-0.6
Left kidney weight	0.2	0.9	1.8	1.3	1.3	1.0	0.0	-0.4
Right kidney weight	0.2	0.8	1.1	1.1	1.0	1.0	-0.5	-0.7
Cocaine induced anxiety	0.0	0.1	0.1	0.3	0.3	0.2	-0.1	-0.2
Post-drug Anxiety	0.7	0.8	1.4	1.2	1.1	0.8	-0.5	-0.5
Baseline Anxiety	0.5	0.5	0.6	0.8	0.8	0.8	-0.8	-0.6
Tail length	1.5	5.8	7.3	2.7	2.7	2.5	-2.0	-2.1
Length with tail	0.7	3.1	5.5	2.3	2.3	1.7	-0.8	-1.2
Length without tail	0.1	0.2	0.6	0.2	0.2	-0.2	0.8	0.6
Times rat made contact with spout	0.8	0.9	1.1	0.8	0.9	1.0	-1.1	-0.9
Lifetime Intake	0.2	0.2	0.3	0.6	0.6	0.6	-0.2	-0.3
Liver weight, left	0.0	0.1	0.2	-0.1	-0.2	-0.0	0.5	0.3
Liver weight, right	0.2	0.3	0.6	-0.8	-0.7	-0.5	0.2	0.3
Locomotor activity	0.0	0.0	0.0	0.1	0.1	-0.0	-0.1	0.0
Locomotor testing distance	0.2	0.4	0.8	-0.3	-0.4	-0.7	0.8	0.9
Locomotor testing rearing	0.6	1.2	1.9	1.4	1.4	1.1	-0.8	-0.7
Locomotion in novel chamber	0.1	0.1	0.2	-0.5	-0.5	-0.3	0.1	0.1
Locomotion in novel chamber post-restriction	1.9	3.1	4.1	1.5	1.5	1.9	-2.0	-1.8
Fecal boli incidents, locomotor time 1	1.1	1.6	2.0	-1.4	-1.4	-1.3	1.0	1.1
Change in fecal boli incidents, locomotor task	0.3	0.2	0.5	0.7	0.7	0.4	-0.1	-0.2
Time >=10cm from walls, locomotor time 1	0.0	0.0	0.1	0.1	0.1	0.0	0.3	0.2
Bouts of movement, locomotor time 1	0.8	0.9	1.4	-1.2	-1.2	-0.7	0.7	0.9
Total resting periods, locomotor time 1	1.0	1.1	2.0	-1.4	-1.4	-0.8	0.6	0.9
Rest time, locomotor task time 1	0.4	0.5	1.0	-1.0	-1.0	-0.1	-0.5	-0.3
Distance moved, locomotor task time 1	0.7	1.0	2.2	1.5	1.4	0.8	-0.1	-0.4
Vertical activity count, locomotor time 1	0.2	0.5	1.1	1.1	1.0	0.4	0.4	0.1
Time >=10cm from walls, locomotor time 2	0.0	0.0	0.1	0.1	0.1	0.2	0.2	-0.1
Bouts of movement, locomotor time 2	0.5	0.8	0.9	1.0	1.0	0.9	-0.9	-0.6
Total resting periods, locomotor time 2	0.2	0.4	0.5	0.6	0.7	0.6	-0.7	-0.4
Rest time, locomotor task time 2	0.2	0.2	0.6	-0.8	-0.7	-0.3	0.1	0.1
Distance moved, locomotor task time 2	0.5	0.6	0.7	0.8	0.8	0.8	-0.8	-0.8
Vertical activity count, locomotor time 2	0.2	0.3	0.6	0.8	0.7	0.4	-0.1	-0.3
Light reinforcement 1	0.3	0.7	1.6	1.2	1.2	0.5	0.6	-0.0
Light reinforcement 2	0.3	0.5	1.5	0.4	0.3	-0.2	1.2	0.7
Bone: marrow area	0.8	1.8	2.8	1.7	1.6	1.3	-0.8	-1.0
Bone: maximum diameter	2.6	4.9	5.5	2.3	2.3	2.2	-2.2	-2.0
Bone: maximum force	4.2	7.4	8.0	2.8	2.8	2.8	-2.6	-2.6
Bone: maximum moment	3.6	6.4	7.0	2.5	2.6	2.6	-2.5	-2.4
Mean time between licks in bursts	0.2	0.5	0.6	-0.7	-0.7	-0.8	0.6	0.6
Mean num. licks in bursts	2.0	3.1	3.9	-2.0	-2.0	-1.8	1.5	1.5
Cd content in liver	1.3	1.5	1.7	1.3	1.3	1.2	-1.1	-1.2
Co content in liver	0.7	0.9	1.4	-0.7	-0.7	-0.9	1.2	1.0
Cu content in liver	1.0	1.2	1.8	-1.3	-1.3	-1.0	0.8	0.8
Fe content in liver	1.2	1.4	2.2	-0.9	-1.0	-1.2	1.5	1.3
K content in liver	0.4	0.4	0.7	-0.5	-0.5	-0.6	0.8	0.5
Mg content in liver	1.1	1.1	1.3	-1.1	-1.2	-1.1	1.0	0.9
Mn content in liver	2.5	2.8	3.3	1.4	1.5	1.8	-1.8	-1.8
Na content in liver	0.6	0.7	1.1	-1.0	-1.0	-0.7	0.5	0.7
Rb content in liver	4.8	5.6	6.7	-2.5	-2.5	-2.6	2.2	2.0
Se content in liver	3.7	4.4	5.0	2.0	2.0	2.2	-2.1	-2.1
Sr content in liver	0.4	0.3	0.5	0.5	0.5	0.7	-0.5	-0.6
Zn content in liver	0.0	0.0	0.1	0.1	0.1	0.2	-0.3	-0.3
Bone: minimum diameter	0.0	0.0	0.0	-0.2	-0.2	-0.1	-0.2	0.0
Time in familiar zone, hab. session 1	0.5	0.5	1.7	-0.4	-0.3	0.3	-1.3	-0.8
Time in novel zone, hab. session 1	3.8	3.8	6.6	-1.4	-1.5	-1.9	2.6	2.2
Total zone transitions, hab. session 1	0.0	0.0	0.1	-0.1	-0.1	-0.2	0.2	0.1
Total locomotion distance, hab. session 1	0.7	0.9	1.8	0.6	0.7	0.9	-1.3	-1.2
Locomotion velocity, hab. session 1	1.9	2.7	3.5	1.5	1.5	1.6	-1.9	-1.8
Time in familiar zone, hab. session 2	0.3	0.3	0.6	-0.8	-0.7	-0.4	-0.4	-0.0
Time in novel zone, hab. session 2	2.0	2.1	3.8	-1.1	-1.1	-1.3	1.9	1.5
Total zone transitions, hab. session 2	0.1	0.2	0.4	0.7	0.6	0.1	0.3	-0.1
Total locomotion distance, hab. session 2	0.6	0.8	1.0	1.0	1.0	0.7	-0.7	-0.9
Locomotion velocity, hab. session 2	0.8	1.0	1.3	1.1	1.1	0.9	-0.9	-1.0
Novel to familiar place preference ratio	4.0	4.4	5.4	-2.0	-2.0	-2.0	2.3	2.1
Novelty place preference	5.0	5.3	5.9	-2.3	-2.3	-2.3	2.4	2.3
Time in novel zone, NPP test	6.0	6.4	7.2	-2.5	-2.5	-2.5	2.7	2.5
Total zone transitions, NPP test	0.2	0.2	0.6	0.7	0.7	0.2	0.2	-0.2
Total locomotion distance, NPP test	0.8	1.1	2.0	1.4	1.4	0.9	-0.5	-0.9
Locomotion velocity, NPP test	1.2	1.7	2.7	1.7	1.6	1.1	-0.8	-1.2
Intraocular pressure	1.6	2.3	3.3	1.8	1.8	1.4	-1.1	-1.2
Delta distance traveled before/after self-admin	0.1	0.1	0.2	0.1	0.1	0.4	-0.5	-0.4
Delta ambulatory time before/after self-admin	0.1	0.1	0.2	-0.4	-0.4	-0.1	-0.1	-0.0
Parametrial fat weight	0.4	0.9	1.5	-0.6	-0.7	-1.0	1.2	1.0
Pavlov. Cond. lever latency	5.9	7.4	10.0	-3.2	-3.1	-2.7	2.0	2.5
Pavlov. Cond. magazine entry latency	0.3	0.4	0.6	0.7	0.7	0.5	-0.4	-0.6
Pavlov. Cond. change in total contacts	2.0	2.1	3.2	1.8	1.7	1.4	-0.8	-1.3
Pavlov. Cond. index score	2.8	3.5	4.6	2.1	2.1	1.8	-1.5	-1.7
Pavlov. Cond. latency score	2.6	3.2	4.3	2.1	2.0	1.7	-1.4	-1.7
Pavlov. Cond. lever contacts	5.5	6.6	8.8	3.0	2.9	2.5	-1.9	-2.3
Pavlov. Cond. magazine entry number	0.5	0.6	0.8	-0.9	-0.9	-0.7	0.7	0.8
Pavlov. Cond. intertrial magazine entries	0.2	0.2	0.3	0.5	0.5	0.5	-0.5	-0.4
Pavlov. Cond. lever-magazine prob. diff.	3.0	3.7	4.5	2.1	2.1	1.9	-1.6	-1.8
Pavlov. Cond. response bias	3.1	3.8	5.3	2.3	2.2	1.9	-1.5	-1.8
Pavlov. Cond. lever latency	3.3	4.6	5.5	-2.0	-2.1	-2.2	2.3	2.1
Pavlov. Cond. magazine entry latency	0.0	0.0	0.1	-0.3	-0.3	-0.1	-0.2	0.1
Pavlov. Cond. change in total contacts	1.3	2.2	4.1	1.1	1.2	1.3	-2.0	-1.5
Pavlov. Cond. index score	0.6	0.9	1.8	0.6	0.7	0.9	-1.3	-0.9
Pavlov. Cond. latency score	0.9	1.2	2.4	0.8	0.8	1.0	-1.5	-1.1
Pavlov. Cond. lever contacts	2.5	3.5	4.4	1.7	1.8	1.9	-2.1	-1.8
Pavlov. Cond. magazine entry number	0.6	0.8	1.9	-0.5	-0.6	-0.8	1.4	0.9
Pavlov. Cond. intertrial magazine entries	0.1	0.2	0.3	0.5	0.5	0.5	-0.2	-0.3
Pavlov. Cond. lever-magazine prob. diff.	0.7	0.9	2.0	0.6	0.7	0.9	-1.4	-1.0
Pavlov. Cond. response bias	1.5	2.1	3.3	1.2	1.3	1.4	-1.8	-1.4
Time in closed arm before self-admin	0.5	0.7	0.8	-0.9	-0.9	-0.9	0.6	0.7
Time in closed arm after self-admin	0.1	0.1	0.1	-0.3	-0.3	-0.2	-0.2	-0.1
Time in open arm before self-admin	0.4	0.5	1.0	1.0	1.0	0.6	-0.1	-0.3
Time in open arm after self-admin	0.4	0.5	0.8	0.9	0.9	0.7	-0.2	-0.4
Bone: periosteal estimation	1.8	3.8	4.6	2.1	2.1	2.0	-1.7	-1.7
Bone: periosteal perimeter	0.4	0.6	1.2	1.1	1.0	0.8	-0.4	-0.5
Bone: post-yield work	1.7	2.5	3.8	1.9	1.9	1.7	-1.0	-1.2
Progressive ratio test 1 active lever presses	0.1	0.1	0.2	-0.1	-0.1	-0.1	0.5	0.4
Progressive ratio test 1 breakpoint	0.0	0.0	0.1	0.0	0.0	0.0	0.4	0.3
Progressive ratio test 1 inactive lever presses	0.3	0.5	1.0	1.0	1.0	0.7	0.0	-0.1
Progressive ratio test 2 active lever presses	0.2	0.2	0.5	-0.2	-0.2	-0.3	0.7	0.6
Progressive ratio test 2 breakpoint	0.2	0.2	0.6	-0.3	-0.3	-0.3	0.7	0.6
Progressive ratio test 2 inactive lever presses	0.2	0.4	0.5	0.7	0.7	0.7	-0.4	-0.4
Incentive Sensitization - Responses	0.0	0.0	0.1	0.3	0.3	0.1	0.1	-0.0
Incentive Sensitization - Breakpoint	0.0	0.0	0.0	0.2	0.1	-0.0	0.2	0.1
Sum of active levers in priming session hrs 5-6	5.5	5.1	6.2	-2.0	-2.1	-2.1	2.5	2.5
Progressive ratio	0.2	0.3	0.5	-0.4	-0.4	-0.6	0.7	0.6
Food seeking constrained by brief footshock	4.6	5.7	9.3	3.1	3.0	2.3	-1.4	-1.7
Seeking ratio, punishment vs. effort	2.5	3.6	4.5	2.1	2.1	2.0	-1.6	-1.7
Retroperitoneal fat weight	0.4	1.5	2.1	-1.4	-1.4	-1.4	0.7	1.1
Reaction time number correct	0.0	0.1	0.2	0.1	0.0	-0.2	0.4	0.4
Reaction time mean minus median	0.8	1.9	4.6	0.6	0.7	1.4	-2.1	-1.5
Reaction time mean minus median AUC	1.1	2.8	5.3	1.1	1.2	1.8	-2.3	-1.7
Reaction time num false alarms	0.4	0.5	1.0	0.4	0.4	1.0	-1.0	-0.6
Reaction time num false alarms AUC	0.7	1.0	1.6	0.9	0.9	1.3	-1.1	-0.8
Reaction time trials correct on left	0.0	0.1	0.2	0.1	0.0	-0.2	0.4	0.4
Reaction time trials on left	0.1	0.1	0.2	-0.1	-0.1	-0.3	0.5	0.5
Reaction time mean	0.4	0.7	1.6	-1.3	-1.2	-0.6	-0.4	0.2
Reaction time mean AUC	0.5	0.7	1.7	-1.3	-1.2	-0.5	-0.5	0.2
Median of all reaction times	1.5	2.1	3.7	-1.9	-1.9	-1.4	0.6	1.1
Reaction time omissions	1.6	2.4	3.1	-1.8	-1.8	-1.4	1.3	1.4
Reaction time false alarm rate	0.2	0.3	0.7	0.2	0.3	0.8	-0.8	-0.5
Reaction time premature initiation rate	1.5	2.1	3.2	-1.8	-1.7	-1.5	0.8	1.1
Reaction time premature initiations	1.1	1.9	2.5	-1.6	-1.6	-1.5	1.0	1.2
Std. dev. reaction times	0.3	0.6	2.1	-0.2	-0.1	0.5	-1.5	-0.7
Reaction time trials completed	0.1	0.1	0.2	-0.1	-0.1	-0.3	0.5	0.5
Reaction time trials AUC	0.1	0.1	0.2	-0.1	-0.1	-0.3	0.5	0.5
Run reversals in cocaine runway, females	0.1	0.1	0.1	-0.4	-0.3	-0.1	-0.3	0.0
Run reversals in cocaine runway, males	0.0	0.0	0.1	-0.2	-0.2	-0.1	0.1	0.0
Latency to leave start box in cocaine runway	0.8	0.9	1.1	1.0	1.0	1.1	-0.9	-0.9
Latency to leave start box in cocaine runway, F	0.3	0.3	0.6	-0.4	-0.4	-0.5	0.8	0.6
Latency to leave start box in cocaine runway, M	3.7	3.4	3.8	1.9	2.0	1.9	-1.6	-1.8
Std. dev. time between licks in bursts	0.2	0.3	0.4	-0.6	-0.6	-0.6	0.3	0.4
Total sessions with >9 infusions	0.2	0.3	0.5	0.7	0.7	0.6	-0.2	-0.3
Short access day 1 total inactive lever presses	0.4	0.6	1.3	1.1	1.1	0.6	0.1	-0.2
Short access day 10 total inactive lever presses	0.5	1.1	1.4	1.2	1.2	1.1	-0.8	-0.9
Short access day 1 total infusions	0.3	0.3	0.7	0.8	0.8	0.5	0.1	-0.2
Short access day 10 total infusions	0.2	0.3	0.6	-0.1	-0.1	-0.5	0.7	0.7
Short access total infusions	0.1	0.1	0.2	0.2	0.2	0.0	0.5	0.3
Short access day 1 locomotion	1.7	2.1	2.5	-1.3	-1.3	-1.5	1.4	1.6
Short access day 10 total locomotion	0.3	0.6	1.2	-1.1	-1.0	-0.8	0.3	0.6
Short access total locomotion	0.6	0.7	1.0	-0.8	-0.8	-0.9	0.8	1.0
One hour access (0.3 mA shock)	0.1	0.1	0.2	0.4	0.4	0.5	0.0	-0.1
Compulsive drug intake	0.0	0.0	0.1	0.1	0.1	-0.0	-0.3	-0.1
One hour access (shock baseline)	0.1	0.1	0.4	0.2	0.2	0.0	0.6	0.3
Social response proportion	2.3	2.6	3.2	-1.8	-1.8	-1.7	1.2	1.5
Social responses	0.4	0.5	0.8	0.9	0.9	0.7	-0.6	-0.6
Social time	0.1	0.1	0.3	-0.2	-0.2	-0.2	0.5	0.4
Soleus weight	0.4	1.3	3.1	-0.3	-0.4	-1.0	1.8	1.4
Bone: stiffness	5.5	8.9	9.8	3.1	3.1	3.1	-2.7	-2.8
Tibialis anterior weight	6.5	22.0	29.7	5.4	5.4	4.7	-3.7	-3.9
Time to tail flick, vehicle, before self-admin	1.0	1.1	1.4	-1.2	-1.2	-1.1	0.8	0.7
Time to tail flick, vehicle, after self-admin	0.0	0.1	0.2	0.1	0.2	0.1	-0.4	-0.3
Time to tail flick, test, before self-admin	0.6	0.6	0.7	0.8	0.8	0.8	-0.7	-0.8
Time to tail flick, test, after self-admin	1.3	1.4	2.4	1.0	1.0	1.0	-1.5	-1.1
Delta time to tail flick, vehicle, before/after SA	0.4	0.4	0.6	0.8	0.8	0.6	-0.6	-0.4
Delta time to tail flick, test, before/after SA	0.1	0.1	0.1	-0.4	-0.3	-0.3	-0.2	0.1
Tibia length	0.1	0.2	0.5	0.3	0.2	-0.1	0.7	0.3
Ambulatory time before self-admin	2.3	3.5	5.4	2.3	2.3	1.8	-1.2	-1.5
Ambulatory time after self-admin	1.4	1.7	2.1	1.4	1.4	1.4	-1.0	-1.2
Bone: tissue strength	0.2	0.2	0.3	0.5	0.5	0.5	-0.5	-0.5
Total heroin consumption	1.2	1.4	1.9	-1.1	-1.1	-1.1	1.4	1.4
Bone: trabecular number	1.0	1.7	2.2	1.2	1.2	1.2	-1.5	-1.3
Bone: trabecular spacing	0.1	0.2	0.3	0.3	0.3	0.5	-0.6	-0.4
Bone: trabecular thickness	0.1	0.2	0.2	-0.5	-0.5	-0.5	0.1	0.2
Bone: trabecular tissue density	3.9	5.7	6.5	2.5	2.5	2.5	-2.1	-2.2
Water consumed over 24 hours	1.1	1.4	1.7	1.3	1.3	1.2	-1.0	-1.1
Number of responses in last shaping day	1.2	1.3	2.9	-0.2	-0.3	-1.0	1.7	1.5