Hub : Genes

Dop1b

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Brain gene expression Dop1b 0.15 0.08 1.9e-09 0.09 0.09 0.08 0.1 1.6e-08 1.6e-08 3.4e-08 3.7e-09
2 Liver gene expression Dop1b 0.09 0.05 2.6e-10 0.07 0.07 0.04 0.06 6.1e-08 6.0e-08 9.1e-06 1.3e-07
3 OFC gene expression Dop1b 0.15 0.09 2.5e-03 0.14 0.11 0.1 0.12 4.0e-04 1.3e-03 1.8e-03 7.9e-04
4 PL gene expression Dop1b 0.05 0.03 4.2e-07 0.05 0.07 0.07 0.07 1.8e-06 2.8e-08 8.9e-08 6.6e-08
5 PL mRNA stability Dop1b 0.09 0.05 1.1e-07 0.03 0.07 0.06 0.06 1.2e-04 5.3e-08 7.7e-07 2.7e-07
6 NAcc isoform ratio XM_039088417.2 0.04 0.02 2.9e-04 0 0.01 0.01 0.01 1.2e-01 3.9e-03 2.7e-02 1.8e-02
7 BLA gene expression Dop1b 0.11 0.07 1.3e-04 0.06 0.05 0.05 0.06 4.7e-04 1.2e-03 1.3e-03 6.1e-04
8 Adipose gene expression Dop1b 0.15 0.08 2.5e-09 0.09 0.06 0.07 0.08 1.2e-09 1.4e-07 1.4e-08 5.1e-09
9 NAcc isoform ratio NM_001191660.2 0.03 0.02 1.0e-03 0.01 0.01 0 0 4.0e-02 1.0e-02 1.1e-01 5.9e-02
10 Brain mRNA stability Dop1b 0.06 0.04 1.1e-03 0.01 0.04 0.03 0.03 3.1e-02 2.8e-04 5.0e-04 1.6e-03
11 NAcc intron excision ratio chr11_46564118_46565476 0.04 0.03 6.8e-04 0.01 0.02 0.01 0.01 6.3e-03 1.2e-03 7.1e-03 5.6e-03
12 pVTA isoform ratio NM_001191660.2 0.1 0.06 1.1e-04 0.04 0.05 0.05 0.04 1.9e-04 8.7e-05 7.4e-05 2.6e-04
13 Adipose mRNA stability Dop1b 0.07 0.04 2.4e-04 0.03 0.03 0.03 0.03 1.4e-04 2.8e-04 3.4e-04 6.2e-04
14 Brain isoform ratio NM_001191660.2 0.06 0.04 8.4e-03 0.03 0.01 0 0.02 5.5e-04 5.6e-02 2.9e-01 8.9e-03
15 NAcc intron excision ratio chr11_46529618_46530770 0.03 0.02 6.9e-03 0.01 -0 0 0 2.5e-02 4.9e-01 1.7e-01 2.2e-01
16 pVTA intron excision ratio chr11_46564118_46565476 0.09 0.06 1.1e-04 0.07 0.06 0.04 0.06 4.9e-06 2.2e-05 3.4e-04 1.2e-05
17 NAcc gene expression Dop1b 0.21 0.1 3.6e-13 0.07 0.08 0.07 0.08 3.4e-11 4.7e-12 1.9e-11 1.3e-11
18 pVTA isoform ratio XM_039088417.2 0.17 0.1 2.2e-05 0.06 0.06 0.06 0.06 8.7e-06 6.3e-06 2.6e-05 1.4e-05
19 IC isoform ratio XM_039088417.2 0.19 0.11 2.4e-03 0.02 0.01 0 0.02 4.1e-02 1.2e-01 2.5e-01 6.2e-02
20 IC intron excision ratio chr11_46564118_46565476 0.13 0.07 3.1e-03 0.07 0.02 0.02 0.05 5.6e-04 4.1e-02 3.8e-02 3.4e-03
21 PL intron excision ratio chr11_46589503_46591412 0.05 0.04 2.6e-03 0.03 0.01 0.02 0.02 2.6e-04 1.2e-02 3.1e-03 2.4e-03
22 Brain intron excision ratio chr11_46564118_46565476 0.06 0.04 5.4e-03 0.03 0.01 0 0.02 5.7e-04 4.3e-02 1.2e-01 7.5e-03
23 Brain intron excision ratio chr11_46543384_46544888 0.06 0.04 4.6e-03 0 0.01 0.01 0.01 1.1e-01 1.8e-02 8.4e-02 3.4e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23
Bone: apparent density0.40.61.20.40.30.40.10.90.90.7-0.6-1.01.1-1.1-0.6-0.8-0.80.8-0.80.20.61.0-1.01.0-0.8-0.9
Area under the delay curve1.61.94.8-0.5-0.3-0.4-0.30.91.2-0.1-0.6-1.21.0-1.4-1.8-1.9-1.71.7-1.71.72.21.7-1.71.7-1.80.0
BMI with tail0.41.53.41.01.21.41.11.71.80.80.1-1.71.8-1.4-1.2-1.1-1.11.1-1.11.01.01.0-1.01.0-1.3-0.4
BMI without tail0.30.82.1-0.0-0.00.2-0.21.01.1-0.4-0.4-1.21.2-1.4-0.9-1.1-1.11.1-1.10.40.90.9-0.90.9-1.3-0.9
Body weight0.00.10.3-0.20.0-0.10.10.20.60.1-0.4-0.40.4-0.4-0.3-0.3-0.20.2-0.20.20.20.1-0.10.1-0.50.4
Weight adjusted by age0.40.52.0-1.3-1.2-1.4-1.1-0.9-0.6-1.3-0.80.6-0.60.20.30.40.3-0.30.3-0.5-0.2-0.40.4-0.40.20.4
Bone surface2.24.010.22.93.13.13.22.42.32.92.0-2.01.8-0.7-1.9-1.2-1.21.2-1.22.51.51.2-1.21.2-1.10.8
Bone volume1.52.65.32.12.32.22.32.01.92.11.2-1.71.6-0.9-1.7-1.2-1.31.3-1.31.91.31.2-1.21.2-1.20.3
Breakpoint value in progressive ratio session0.30.31.80.50.40.40.6-0.4-0.40.21.40.6-0.70.90.40.70.7-0.70.70.4-0.3-0.20.2-0.20.50.9
Number of licking bursts0.30.51.7-0.9-0.8-0.7-1.00.30.3-0.4-1.3-0.50.6-1.0-0.3-0.7-0.70.7-0.7-0.40.40.7-0.70.7-0.7-1.2
Context. condit. distance diff. score0.40.53.6-0.5-0.0-0.40.3-0.7-0.40.21.60.8-1.01.0-0.00.40.4-0.40.40.70.1-0.30.3-0.30.41.9
Locomotion velocity, session 10.20.21.20.20.20.10.10.0-0.20.71.10.2-0.10.30.40.30.3-0.30.3-0.6-0.6-0.50.5-0.50.3-0.2
Locomotion distance, session 10.50.77.10.80.90.81.00.0-0.11.02.70.3-0.40.8-0.00.30.4-0.40.40.4-0.2-0.60.6-0.60.41.1
Locomotion velocity, session 20.30.41.10.30.40.20.5-0.4-0.40.10.60.6-0.60.90.40.60.6-0.60.6-0.2-0.8-0.80.8-0.80.51.1
Locomotion distance, session 20.20.30.7-0.2-0.1-0.10.10.10.30.30.4-0.20.1-0.2-0.8-0.9-0.80.8-0.80.60.50.5-0.50.5-0.70.6
Locomotion velocity, session 32.32.68.02.42.42.32.50.60.02.32.80.1-0.21.31.01.71.7-1.71.70.3-1.0-1.31.3-1.31.51.0
Locomotion distance, session 30.70.72.60.91.01.30.91.21.01.61.4-1.11.1-0.7-0.5-0.4-0.50.5-0.50.40.50.4-0.40.4-0.4-0.6
Stereotopy head waving bouts, day 31.21.44.71.50.81.10.30.3-0.50.6-0.00.10.30.31.81.21.2-1.21.2-2.2-2.1-1.21.2-1.21.3-2.0
Stereotopy head waving duration, day 30.81.02.81.40.80.90.50.2-0.40.30.20.10.20.31.51.21.2-1.21.2-1.6-1.7-0.90.9-0.91.1-1.4
Locomotion velocity, session 70.50.51.8-1.3-1.2-1.2-1.2-1.0-0.9-1.1-0.20.8-0.70.40.50.10.2-0.20.2-0.9-0.5-0.30.3-0.30.2-0.1
Locomotion distance, session 70.60.73.2-1.8-1.5-1.4-1.4-0.6-0.2-1.2-0.30.2-0.2-0.4-0.5-0.9-0.80.8-0.8-0.20.40.7-0.70.7-0.80.2
Stereotopy head waving bouts, day 71.82.03.71.91.71.61.7-0.2-0.61.31.50.7-0.61.61.21.41.4-1.41.4-0.6-1.8-1.81.8-1.81.80.6
Stereotopy head waving duration, day 72.02.44.31.81.71.41.9-0.5-0.81.02.11.1-1.12.11.11.61.6-1.61.6-0.2-1.7-1.91.9-1.91.91.6
Locomotion velocity, session 81.51.87.22.12.21.82.20.60.22.32.70.0-0.01.10.50.91.0-1.01.00.1-1.1-1.01.0-1.00.91.1
Locomotion distance, session 80.30.43.8-0.50.1-0.20.4-0.5-0.10.41.70.5-0.70.8-0.4-0.00.1-0.10.11.00.4-0.10.1-0.10.02.0
Degree of sensitization distance0.80.92.9-1.7-1.6-1.7-1.5-1.3-0.9-1.5-1.11.0-1.00.40.30.00.1-0.10.1-0.6-0.4-0.20.2-0.2-0.00.6
Degree of sensitization stereotypy1.41.54.31.81.91.72.10.1-0.11.61.90.4-0.41.40.20.90.8-0.80.80.6-0.8-1.11.1-1.11.21.5
Conditioned locomotion0.60.71.2-1.0-1.1-1.1-1.0-1.1-1.0-1.1-0.61.0-1.00.60.80.60.6-0.60.6-0.7-0.6-0.60.6-0.60.80.2
Cocaine response after cond. corrected1.11.32.5-0.1-0.1-0.30.1-1.2-1.2-0.61.01.4-1.51.61.11.31.3-1.31.3-0.5-1.1-1.41.4-1.41.41.3
Cocaine response after cond. not corrected1.21.42.5-0.4-0.3-0.6-0.1-1.3-1.3-0.81.11.4-1.51.61.11.41.4-1.41.4-0.4-1.0-1.41.4-1.41.41.4
Cocaine response before conditioning0.10.10.5-0.3-0.1-0.10.00.20.3-0.50.3-0.20.1-0.2-0.4-0.2-0.10.1-0.10.60.70.4-0.40.4-0.20.4
Saline control response0.70.96.01.41.41.31.50.20.00.42.50.1-0.30.80.20.80.8-0.80.80.7-0.2-0.60.6-0.60.81.0
Bone: connectivity density0.91.42.61.31.31.31.21.61.61.60.2-1.51.5-1.1-1.1-0.9-0.90.9-0.91.11.11.2-1.21.2-0.8-0.4
Bone: cortical apparent density0.00.00.3-0.1-0.1-0.1-0.1-0.00.0-0.50.3-0.00.0-0.00.00.10.1-0.10.10.10.10.0-0.00.00.00.0
Bone: cortical area0.81.33.10.60.60.30.9-0.9-0.90.21.61.2-1.21.70.81.11.1-1.11.1-0.0-1.1-1.41.4-1.41.21.8
Bone: cortical porosity0.30.31.1-1.0-1.0-0.9-1.0-0.4-0.2-0.8-0.70.1-0.1-0.3-0.2-0.5-0.50.5-0.5-0.00.50.4-0.40.4-0.3-0.3
Bone: cortical porosity0.20.21.0-0.9-1.0-0.9-0.9-0.5-0.4-0.7-0.60.3-0.3-0.1-0.0-0.2-0.20.2-0.2-0.10.30.1-0.10.1-0.1-0.1
Bone: cortical thickness2.54.17.2-1.5-1.6-2.0-1.3-2.7-2.5-1.80.22.6-2.62.32.12.02.1-2.12.1-1.5-2.0-2.22.2-2.22.11.5
Bone: cortical thickness0.30.30.8-0.7-0.8-0.9-0.8-0.8-0.7-0.7-0.30.7-0.70.40.50.50.5-0.50.5-0.3-0.1-0.30.3-0.30.50.1
Bone: cortical tissue density0.00.00.2-0.1-0.0-0.1-0.10.10.2-0.50.2-0.20.2-0.2-0.1-0.0-0.10.1-0.10.10.20.2-0.20.2-0.1-0.1
Condit. Reinf. active minus inactive responses0.00.00.1-0.0-0.2-0.1-0.2-0.2-0.2-0.0-0.20.2-0.20.1-0.0-0.1-0.10.1-0.10.10.1-0.10.1-0.1-0.1-0.1
Condit. Reinf. active-inactive response ratio0.30.30.7-0.4-0.5-0.5-0.5-0.8-0.9-0.5-0.60.8-0.80.70.50.40.4-0.40.4-0.6-0.6-0.70.7-0.70.40.2
Condit. Reinf. active responses0.10.10.40.1-0.00.00.1-0.1-0.10.60.30.1-0.20.1-0.3-0.2-0.20.2-0.20.60.60.1-0.10.1-0.30.3
Condit. Reinf. inactive responses0.10.11.20.40.30.30.30.1-0.01.11.0-0.0-0.10.10.10.30.3-0.30.30.30.2-0.10.1-0.10.20.1
Incentive salience index mean0.10.10.2-0.4-0.4-0.4-0.4-0.4-0.3-0.0-0.50.3-0.30.1-0.1-0.2-0.20.2-0.20.20.20.0-0.00.0-0.20.1
Condit. Reinf. lever presses0.20.20.7-0.7-0.6-0.9-0.5-0.8-0.6-0.1-0.50.7-0.80.50.10.10.2-0.20.20.1-0.0-0.20.2-0.20.10.7
Condit. Reinf. active minus inactive responses0.50.74.60.60.90.71.20.10.30.62.10.0-0.30.6-0.50.20.2-0.20.21.50.60.0-0.00.0-0.01.8
Condit. Reinf. active-inactive response ratio0.70.82.2-0.10.20.10.30.60.90.20.4-0.70.5-0.6-1.3-0.9-0.90.9-0.91.51.41.1-1.11.1-1.20.6
Condit. Reinf. active responses1.01.46.81.41.51.21.7-0.1-0.20.82.60.5-0.61.30.51.31.3-1.31.30.6-0.6-1.01.0-1.01.01.7
Condit. Reinf. inactive responses1.62.04.11.61.41.21.5-0.3-0.60.62.00.8-0.81.51.31.81.8-1.81.8-0.5-1.7-1.71.7-1.71.71.2
Condit. Reinf. lever presses0.50.73.91.01.21.01.40.0-0.00.62.00.3-0.31.00.20.70.7-0.70.70.3-0.6-0.70.7-0.70.61.3
Condit. Reinf. lever reinforcers received1.01.47.51.51.61.31.80.0-0.00.92.70.4-0.51.20.41.11.1-1.11.10.7-0.5-0.90.9-0.90.91.8
Conditioned reinforcement - actives0.40.84.3-2.1-1.5-1.6-1.4-1.1-0.6-1.4-0.70.7-0.80.20.1-0.0-0.10.1-0.1-0.00.20.5-0.50.5-0.30.6
Conditioned reinforcement - inactives3.04.48.9-2.3-2.3-2.4-2.1-2.9-3.0-2.0-0.62.9-2.92.22.21.91.9-1.91.9-1.7-1.6-1.71.7-1.71.80.7
Conditioned locomotion0.30.41.1-0.5-0.7-0.6-0.6-1.0-1.0-0.9-0.11.0-1.00.80.50.60.5-0.50.5-0.4-0.4-0.50.5-0.50.60.2
Patch foraging indifference point 0 sec2.85.18.5-1.3-1.2-1.8-1.1-2.5-2.6-0.8-0.42.6-2.42.52.72.62.7-2.72.7-2.5-2.9-2.62.6-2.62.41.2
Patch foraging indifference point AUC0.81.23.11.41.20.91.4-0.3-0.30.11.20.6-0.71.30.51.21.1-1.11.10.3-0.8-1.41.4-1.41.11.8
Delay disc. indifference point, 0s delay1.51.73.7-0.20.1-0.10.20.91.20.0-0.0-1.00.8-1.0-1.9-1.9-1.71.7-1.71.71.91.6-1.61.6-1.60.4
Delay disc. indifference point, 16s delay0.91.01.9-0.2-0.3-0.0-0.40.70.80.0-0.7-0.90.9-1.2-1.1-1.4-1.41.4-1.40.71.21.2-1.21.2-1.2-0.7
Delay disc. indifference point, 2s delay1.61.73.7-0.20.10.10.11.21.40.6-0.5-1.41.3-1.4-1.6-1.7-1.61.6-1.61.41.91.7-1.71.7-1.7-0.4
Delay disc. indifference point, 24s delay0.50.61.4-1.1-1.1-1.0-0.9-0.5-0.2-1.2-0.50.2-0.4-0.3-0.7-1.0-0.90.9-0.90.71.10.5-0.50.5-0.50.3
Delay disc. indifference point, 4s delay1.41.53.1-0.00.1-0.10.20.91.3-0.1-0.1-1.11.0-1.2-1.7-1.6-1.41.4-1.41.61.81.6-1.61.6-1.70.5
Delay disc. indifference point, 8s delay0.40.41.3-0.9-0.7-0.9-0.6-0.00.2-0.4-0.6-0.20.0-0.4-0.8-0.8-0.60.6-0.60.81.10.7-0.70.7-0.80.5
Indifference point function ln k0.30.62.5-1.5-1.6-1.4-1.5-0.9-0.7-0.7-0.80.6-0.7-0.0-0.1-0.4-0.30.3-0.30.10.70.5-0.50.5-0.3-0.3
Indifference point function log k0.30.62.5-1.5-1.6-1.4-1.5-0.9-0.7-0.7-0.80.6-0.7-0.0-0.1-0.4-0.30.3-0.30.10.70.5-0.50.5-0.3-0.3
Patch foraging total patch changes 0 sec2.44.57.4-1.1-0.9-1.5-0.8-2.3-2.4-0.6-0.22.5-2.32.52.52.52.6-2.62.6-2.2-2.7-2.52.5-2.52.31.3
Patch foraging total patch changes 12 sec2.02.64.51.10.90.51.0-0.9-1.2-0.01.21.3-1.31.91.72.12.1-2.12.1-0.9-2.0-2.12.1-2.11.91.3
Patch foraging total patch changes 18 sec1.52.34.30.70.70.20.9-1.0-1.20.31.31.4-1.42.01.42.01.9-1.91.9-0.5-1.6-2.12.1-2.12.01.6
Patch foraging total patch changes 24 sec0.61.03.90.60.70.31.0-0.7-0.5-0.01.40.9-1.11.40.31.01.0-1.01.00.6-0.4-1.21.2-1.20.92.0
Patch foraging total patch changes 6 sec3.35.09.00.60.50.20.6-1.6-2.00.21.52.1-2.02.72.73.03.0-3.03.0-1.8-3.0-2.92.9-2.92.71.3
Patch foraging time to switch 0 sec0.51.12.2-0.10.10.4-0.11.21.20.2-0.1-1.31.4-1.5-0.9-1.2-1.21.2-1.20.30.91.3-1.31.3-1.1-1.2
Patch foraging water rate 0 sec0.61.23.61.41.41.11.4-0.0-0.51.91.00.6-0.51.40.91.21.2-1.21.2-0.4-1.2-1.21.2-1.21.10.6
Patch foraging water rate 12 sec0.91.93.2-1.8-1.3-1.7-1.1-1.8-1.6-0.5-0.11.7-1.61.51.31.51.4-1.41.4-1.2-1.3-1.21.2-1.21.41.1
Patch foraging water rate 18 sec0.30.40.90.50.60.60.50.90.80.90.2-0.80.8-0.6-0.5-0.4-0.40.4-0.40.60.80.8-0.80.8-0.6-0.5
Patch foraging water rate 24 sec0.30.41.5-1.0-0.6-0.8-0.3-0.7-0.50.40.40.7-0.90.7-0.00.30.4-0.40.40.80.7-0.10.1-0.10.31.2
Patch foraging water rate 6 sec0.10.21.2-0.3-0.1-0.30.0-0.4-0.50.51.10.5-0.60.70.20.40.4-0.40.40.10.1-0.30.3-0.30.30.7
Seeking ratio, delayed vs. immediate footshock1.21.54.2-0.4-0.6-0.3-0.91.01.00.3-2.0-1.31.5-1.8-0.8-1.4-1.51.5-1.5-0.30.81.1-1.11.1-1.4-2.1
Distance traveled before self-admin0.40.51.30.50.40.40.5-0.5-0.6-0.41.10.7-0.71.00.60.60.8-0.80.8-0.2-0.8-1.11.1-1.10.70.5
Distance traveled after self-admin1.21.42.60.20.20.30.01.21.4-0.1-0.7-1.51.5-1.6-1.5-1.6-1.61.6-1.60.81.21.1-1.11.1-1.6-0.8
Extensor digitorum longus weight1.97.421.84.74.54.64.23.73.23.82.1-3.13.0-1.6-1.9-1.2-1.21.2-1.22.31.51.4-1.41.4-1.4-0.7
Bone: elastic displacement0.20.31.7-0.5-0.7-0.6-0.9-0.2-0.4-0.4-1.30.1-0.0-0.20.60.30.3-0.30.3-0.7-0.10.1-0.10.10.3-1.0
Bone: elastic work0.20.20.60.3-0.1-0.1-0.2-0.3-0.50.8-0.50.4-0.30.30.70.50.5-0.50.5-0.6-0.5-0.40.4-0.40.6-0.5
Bone: endosteal estimation2.65.610.12.93.03.22.92.92.82.91.3-2.62.4-1.6-2.7-2.2-2.22.2-2.22.62.01.9-1.91.9-2.00.1
Bone: endosteal perimeter0.91.86.22.02.32.22.51.21.21.81.9-0.80.60.2-1.3-0.7-0.70.7-0.71.80.60.4-0.40.4-0.51.6
Epididymis fat weight0.31.05.91.01.31.01.60.20.40.82.4-0.0-0.30.7-0.60.00.3-0.30.31.70.6-0.20.2-0.20.12.2
Delta time in closed arm before/after self-admin2.92.74.8-0.1-0.00.2-0.21.41.9-0.2-1.3-1.81.8-2.2-1.8-2.2-2.12.1-2.10.91.52.2-2.22.2-1.9-0.8
Delta time in open arm before/after self-admin0.20.21.50.60.70.60.60.50.11.20.6-0.20.20.20.00.20.0-0.00.00.10.1-0.30.3-0.30.1-0.3
Diff in mean of infusions in LGA sessions1.21.53.11.41.21.11.4-0.6-0.90.81.71.1-1.31.80.91.51.6-1.61.60.5-0.8-0.80.8-0.81.51.5
Delay discount exponential model param1.41.64.00.50.40.40.3-0.8-1.10.10.61.0-0.91.31.71.71.6-1.61.6-1.5-2.0-1.61.6-1.61.7-0.0
Extinction: sum of active levers before priming1.21.33.30.10.4-0.00.6-1.0-1.1-0.01.81.3-1.41.71.11.41.5-1.51.5-0.1-1.0-1.01.0-1.01.31.7
Active lever presses in extinction session 64.24.27.60.0-0.4-0.4-0.4-1.8-2.2-0.70.82.1-1.92.12.82.62.7-2.72.7-2.1-2.7-2.62.6-2.62.40.1
Bone: final force0.30.51.31.00.90.71.0-0.1-0.21.11.10.4-0.40.80.10.30.3-0.30.30.1-0.6-0.80.8-0.80.51.0
Bone: final moment0.40.61.61.00.90.71.0-0.2-0.31.21.20.5-0.51.00.10.40.4-0.40.40.1-0.7-0.90.9-0.90.61.1
Food consumed during 24 hour testing period0.81.11.7-0.9-0.8-0.9-0.7-1.2-1.1-1.20.11.2-1.01.01.21.11.1-1.11.1-1.2-1.3-1.01.0-1.01.00.5
Glucose1.82.910.33.23.23.13.21.71.32.53.1-1.11.00.3-0.40.30.3-0.30.31.30.1-0.10.1-0.10.40.9
Heart weight0.61.02.0-0.1-0.10.1-0.10.50.9-0.8-0.6-0.80.7-1.1-1.2-1.4-1.41.4-1.41.01.21.2-1.21.2-1.4-0.3
Delay discount hyperbolic model param1.51.64.20.50.30.40.2-0.8-1.20.00.51.1-0.91.31.71.71.6-1.61.6-1.6-2.1-1.61.6-1.61.7-0.1
Intermittent access intake day 1-15 change0.61.32.4-0.8-1.2-1.0-1.1-1.5-1.5-1.1-0.61.4-1.41.01.41.11.3-1.31.3-1.2-1.1-0.80.8-0.81.2-0.1
Intermittent access intake escalation0.51.01.8-0.7-1.1-0.9-1.1-1.3-1.3-1.1-0.81.2-1.10.81.30.91.1-1.11.1-1.3-1.1-0.60.6-0.61.0-0.3
Intermittent access intake escalation 21.21.33.0-0.0-0.3-0.2-0.2-1.3-1.4-0.50.61.4-1.41.41.51.51.7-1.71.7-0.7-1.1-1.01.0-1.01.30.6
Intermitt. access day 1 inactive lever presses0.52.04.6-1.9-2.1-2.1-2.0-1.9-1.7-2.1-1.41.7-1.60.91.20.81.0-1.01.0-1.4-1.0-0.70.7-0.70.90.2
Intermitt. access day 15 inactive lever presses1.42.97.2-0.7-1.0-1.0-0.6-2.4-2.4-1.70.82.5-2.72.31.41.61.5-1.51.5-0.6-1.3-2.02.0-2.01.91.4
Intermitt. access escalation Index0.10.20.8-0.7-0.8-0.9-0.7-0.4-0.3-0.3-0.80.3-0.3-0.1-0.0-0.2-0.20.2-0.2-0.20.2-0.00.0-0.0-0.0-0.1
Intermittent access day 1 total infusions0.50.93.4-1.8-1.4-1.6-1.2-1.3-1.2-0.9-0.31.2-1.30.90.50.50.4-0.40.4-0.20.0-0.50.5-0.50.20.6
Intermittent access day 15 total infusions2.23.26.6-2.0-2.2-2.3-2.0-2.4-2.6-1.8-0.92.4-2.31.81.81.51.5-1.51.5-1.6-1.2-1.51.5-1.51.40.2
Intermittent access terminal intake (last 3 days)2.22.95.8-2.0-2.1-2.2-1.9-2.4-2.4-1.8-0.62.3-2.31.71.61.61.6-1.61.6-1.2-0.9-1.21.2-1.21.20.5
Intermittent access total infusions1.82.24.4-2.1-1.9-2.1-1.8-2.0-2.1-1.5-0.71.9-1.91.51.41.31.1-1.11.1-1.2-0.8-1.11.1-1.11.00.3
Intermittent access day 1 locomotion1.01.35.7-2.3-2.0-2.4-1.9-1.5-1.3-1.4-1.31.2-1.20.60.10.0-0.10.1-0.1-0.6-0.0-0.40.4-0.4-0.00.3
Intermittent access day 15 total locomotion1.93.46.8-0.9-1.0-1.4-0.7-2.4-2.4-1.00.72.6-2.62.61.62.01.9-1.91.9-1.0-1.7-2.02.0-2.01.91.7
Intermittent access total locomotion3.64.39.1-2.2-2.2-2.6-1.8-3.0-2.9-2.1-0.42.9-3.02.51.61.71.6-1.61.6-1.4-1.6-1.91.9-1.91.71.5
Intermittent access standard deviation1.12.24.70.1-0.2-0.3-0.2-1.2-1.6-0.10.41.5-1.41.62.12.02.2-2.22.2-1.6-1.8-1.61.6-1.61.70.3
Left kidney weight0.83.917.9-4.2-3.6-3.7-3.3-2.0-1.1-3.3-2.81.1-1.2-0.3-0.4-0.8-0.80.8-0.8-0.01.01.0-1.01.0-0.70.5
Right kidney weight0.83.914.1-3.8-3.4-3.6-3.2-2.6-1.9-3.5-2.31.9-1.90.71.00.50.6-0.60.6-1.2-0.5-0.20.2-0.20.50.6
Cocaine induced anxiety0.30.51.2-0.2-0.2-0.5-0.1-0.8-1.00.00.31.0-1.01.10.60.80.6-0.60.6-0.4-0.6-0.80.8-0.80.70.6
Post-drug Anxiety0.50.63.60.40.50.20.8-0.6-0.4-0.11.50.8-1.01.2-0.10.50.4-0.40.40.7-0.3-0.60.6-0.60.51.9
Baseline Anxiety0.80.91.6-0.30.00.10.10.71.3-0.6-0.2-1.00.9-1.2-1.2-1.1-1.11.1-1.11.01.11.2-1.21.2-1.10.3
Tail length0.93.46.2-2.1-2.4-2.5-2.3-2.4-2.4-2.5-0.92.2-2.21.41.81.41.5-1.51.5-1.7-1.3-1.51.5-1.51.40.2
Length with tail0.21.02.7-1.3-1.3-1.7-1.1-1.5-1.2-1.2-0.31.3-1.31.00.80.60.8-0.80.8-0.6-0.6-0.70.7-0.70.60.9
Length without tail0.10.41.40.40.40.10.6-0.5-0.40.70.10.6-0.61.00.30.60.8-0.80.80.1-0.5-0.70.7-0.70.61.2
Times rat made contact with spout5.46.212.1-3.3-3.5-3.4-3.4-3.2-3.1-3.1-2.42.9-2.71.72.41.81.8-1.81.8-2.6-1.8-1.91.9-1.91.9-0.0
Lifetime Intake0.81.03.1-1.8-1.7-1.6-1.6-1.2-1.2-1.1-1.11.0-1.00.50.80.60.5-0.50.5-0.9-0.2-0.40.4-0.40.3-0.4
Liver weight, left2.03.311.1-3.3-3.3-3.3-3.3-2.1-1.7-3.1-3.01.4-1.40.10.90.10.2-0.20.2-1.3-0.2-0.20.2-0.20.0-0.7
Liver weight, right1.01.77.3-2.3-2.3-2.1-2.6-0.7-0.6-1.4-2.70.20.0-0.80.6-0.3-0.20.2-0.2-1.8-0.30.1-0.10.1-0.3-1.8
Locomotor activity1.01.65.7-2.3-2.2-2.4-2.0-1.7-1.1-2.0-0.81.3-1.20.50.80.70.8-0.80.8-1.0-0.5-0.20.2-0.20.40.8
Locomotor testing distance0.71.32.8-1.6-1.4-1.7-1.4-1.3-1.2-0.9-0.51.2-1.00.81.21.21.2-1.21.2-1.5-1.1-0.70.7-0.70.90.3
Locomotor testing rearing0.20.41.5-1.2-0.9-1.2-0.8-0.4-0.2-1.0-1.20.2-0.3-0.00.10.30.3-0.30.3-0.10.30.4-0.40.40.00.4
Locomotion in novel chamber0.20.30.7-0.3-0.4-0.4-0.2-0.8-0.8-0.10.40.8-0.90.70.60.60.6-0.60.6-0.1-0.2-0.60.6-0.60.50.5
Locomotion in novel chamber post-restriction0.40.71.40.70.50.90.31.00.80.4-0.5-1.01.0-1.0-0.6-0.9-0.90.9-0.90.30.61.0-1.01.0-0.5-1.2
Fecal boli incidents, locomotor time 10.71.03.1-1.0-0.4-0.5-0.10.10.6-0.70.3-0.40.1-0.5-1.3-1.3-1.11.1-1.11.81.71.3-1.31.3-1.41.0
Change in fecal boli incidents, locomotor task1.21.23.9-1.2-1.8-1.8-1.9-1.2-1.1-2.0-1.70.9-0.90.10.70.40.4-0.40.4-1.2-0.5-0.40.4-0.40.5-0.6
Time >=10cm from walls, locomotor time 10.91.01.6-0.2-0.6-1.0-0.6-1.2-1.2-1.2-0.41.3-1.21.10.90.91.0-1.01.0-1.0-1.2-1.01.0-1.01.00.5
Bouts of movement, locomotor time 10.10.10.20.50.40.20.40.1-0.10.10.50.1-0.10.30.20.10.3-0.30.3-0.0-0.1-0.20.2-0.20.20.1
Total resting periods, locomotor time 10.10.10.40.40.30.10.4-0.1-0.2-0.00.60.2-0.30.40.20.20.3-0.30.30.1-0.1-0.20.2-0.20.20.4
Rest time, locomotor task time 11.41.75.00.40.70.61.00.91.40.51.3-1.00.7-0.7-1.9-1.4-1.21.2-1.22.21.91.7-1.71.7-1.51.4
Distance moved, locomotor task time 10.60.94.8-0.1-0.7-0.3-1.1-0.2-0.7-0.4-1.80.20.1-0.31.20.60.4-0.40.4-1.8-1.1-0.80.8-0.80.7-2.2
Vertical activity count, locomotor time 10.30.83.00.20.20.1-0.0-0.3-0.70.3-0.50.6-0.20.61.11.00.7-0.70.7-1.6-1.7-1.21.2-1.21.1-0.8
Time >=10cm from walls, locomotor time 20.30.41.31.10.70.80.51.00.80.6-0.2-0.91.0-0.9-0.4-0.6-0.40.4-0.40.10.30.3-0.30.3-0.5-0.9
Bouts of movement, locomotor time 20.71.14.61.21.51.21.80.50.51.32.1-0.2-0.10.6-1.0-0.3-0.20.2-0.21.90.90.2-0.20.2-0.31.8
Total resting periods, locomotor time 20.30.63.50.60.80.51.1-0.00.10.61.70.3-0.50.8-0.7-0.1-0.00.0-0.01.40.60.1-0.10.1-0.11.9
Rest time, locomotor task time 20.50.73.5-0.4-0.4-0.7-0.0-1.1-0.9-0.91.01.1-1.31.20.30.60.8-0.80.80.3-0.3-0.30.3-0.30.61.9
Distance moved, locomotor task time 21.21.57.80.70.31.0-0.11.61.21.0-1.4-1.61.9-1.9-0.4-1.0-1.11.1-1.1-0.30.70.7-0.70.7-0.9-2.8
Vertical activity count, locomotor time 20.91.22.71.01.01.10.71.61.31.6-0.5-1.51.7-1.2-0.9-0.9-1.21.2-1.20.10.50.6-0.60.6-0.9-1.5
Light reinforcement 10.40.91.80.20.40.30.50.81.2-0.00.2-1.01.0-0.9-1.3-1.1-1.11.1-1.11.11.11.2-1.21.2-1.20.4
Light reinforcement 21.93.07.52.52.62.42.72.02.11.91.8-1.71.5-0.7-1.8-1.1-1.01.0-1.02.41.51.0-1.01.0-1.11.1
Bone: marrow area2.75.910.73.03.13.33.13.02.93.01.3-2.62.4-1.6-2.7-2.2-2.22.2-2.22.72.01.9-1.91.9-2.00.2
Bone: maximum diameter0.61.15.41.51.71.42.00.20.21.02.30.2-0.31.1-0.30.30.2-0.20.21.0-0.3-0.60.6-0.60.41.8
Bone: maximum force0.20.42.61.21.00.91.00.2-0.01.60.50.1-0.00.50.20.20.2-0.20.2-0.2-0.7-0.70.7-0.70.50.4
Bone: maximum moment0.20.42.61.10.90.81.00.1-0.01.60.70.2-0.10.60.10.20.2-0.20.2-0.0-0.6-0.70.7-0.70.50.5
Mean time between licks in bursts0.51.13.8-1.7-1.9-1.7-1.9-1.1-1.0-1.8-1.30.8-0.70.00.80.30.3-0.30.3-1.4-0.6-0.30.3-0.30.3-0.7
Mean num. licks in bursts1.82.94.6-0.7-1.0-1.0-0.8-2.0-2.1-1.20.02.1-2.22.01.81.91.9-1.91.9-1.2-1.7-2.02.0-2.02.01.0
Cd content in liver1.11.22.61.30.91.30.61.51.21.1-0.7-1.51.6-1.4-0.8-1.1-1.11.1-1.10.20.70.8-0.80.8-1.1-1.6
Co content in liver0.60.71.90.00.20.10.30.60.90.10.2-0.70.6-0.7-1.2-1.0-0.90.9-0.91.41.41.1-1.11.1-1.20.5
Cu content in liver0.30.30.5-0.6-0.6-0.7-0.6-0.6-0.60.1-0.30.6-0.50.40.70.60.6-0.60.6-0.6-0.4-0.60.6-0.60.6-0.1
Fe content in liver1.72.03.50.20.1-0.10.1-1.2-1.5-0.10.41.5-1.41.71.81.81.9-1.91.9-1.3-1.9-1.81.8-1.81.80.3
K content in liver0.30.30.70.30.50.50.40.80.8-0.20.4-0.80.9-0.7-0.4-0.3-0.30.3-0.30.30.30.6-0.60.6-0.3-0.3
Mg content in liver0.50.51.00.50.70.60.61.01.00.00.9-1.01.0-0.8-0.7-0.6-0.60.6-0.60.70.80.7-0.70.7-0.6-0.4
Mn content in liver0.50.53.00.40.70.50.80.60.80.21.7-0.60.5-0.2-0.9-0.6-0.60.6-0.61.00.80.6-0.60.6-0.50.7
Na content in liver1.61.76.12.12.32.12.41.10.82.32.5-0.60.40.4-0.10.70.7-0.70.71.30.2-0.30.3-0.30.71.1
Rb content in liver0.30.31.2-0.9-0.8-0.8-0.8-0.2-0.0-0.6-1.1-0.00.1-0.4-0.4-0.7-0.70.7-0.70.00.50.4-0.40.4-0.7-0.3
Se content in liver0.60.82.6-0.3-0.8-0.8-0.9-0.8-1.1-1.0-0.60.9-0.70.61.10.60.6-0.60.6-1.6-1.3-0.90.9-0.90.6-0.7
Sr content in liver0.40.41.5-1.2-1.2-1.1-1.1-0.6-0.4-0.8-0.90.4-0.4-0.10.0-0.2-0.20.2-0.2-0.20.20.2-0.20.2-0.2-0.0
Zn content in liver0.00.00.30.1-0.1-0.1-0.1-0.1-0.1-0.60.10.10.00.00.2-0.0-0.00.0-0.0-0.5-0.4-0.20.2-0.2-0.0-0.2
Bone: minimum diameter1.73.110.23.23.23.23.22.01.72.72.7-1.51.3-0.2-1.1-0.5-0.50.5-0.51.60.60.2-0.20.2-0.30.6
Time in familiar zone, hab. session 10.20.21.4-0.20.1-0.00.3-0.20.2-0.90.80.1-0.20.2-0.4-0.1-0.10.1-0.10.70.4-0.00.0-0.0-0.21.2
Time in novel zone, hab. session 10.90.95.40.90.50.90.11.40.81.3-0.6-1.31.4-1.4-0.1-0.5-0.60.6-0.6-0.30.40.8-0.80.8-0.4-2.3
Total zone transitions, hab. session 10.50.62.4-1.6-1.3-1.4-1.0-1.3-0.9-0.60.11.1-1.10.70.10.00.1-0.10.1-0.2-0.2-0.30.3-0.30.11.2
Total locomotion distance, hab. session 10.40.62.2-1.4-1.4-1.5-1.3-1.1-0.8-0.7-0.40.8-0.80.30.40.20.2-0.20.2-0.7-0.3-0.40.4-0.40.20.4
Locomotion velocity, hab. session 10.40.62.4-1.5-1.5-1.5-1.4-1.1-0.8-0.6-0.40.8-0.80.30.40.10.2-0.20.2-0.8-0.4-0.40.4-0.40.20.3
Time in familiar zone, hab. session 21.11.14.00.50.70.80.90.81.1-0.01.9-0.90.6-0.6-1.5-1.0-0.90.9-0.92.01.70.9-0.90.9-0.91.0
Time in novel zone, hab. session 20.40.42.1-0.4-0.6-0.5-0.8-0.2-0.50.2-1.40.20.0-0.10.80.30.2-0.20.2-1.5-0.9-0.20.2-0.20.3-1.4
Total zone transitions, hab. session 20.40.52.6-1.3-0.8-0.8-0.5-0.6-0.0-1.00.70.3-0.60.1-0.8-0.5-0.50.5-0.51.00.80.4-0.40.4-0.61.6
Total locomotion distance, hab. session 20.81.04.0-2.0-1.7-1.6-1.5-0.8-0.1-1.5-0.40.3-0.4-0.4-0.8-0.8-0.80.8-0.80.50.90.7-0.70.7-0.90.7
Locomotion velocity, hab. session 20.70.93.8-1.9-1.6-1.6-1.4-0.7-0.1-1.5-0.60.3-0.4-0.3-0.7-0.8-0.80.8-0.80.30.70.6-0.60.6-0.90.8
Novel to familiar place preference ratio0.40.52.60.1-0.10.1-0.40.70.51.0-1.4-0.70.9-1.0-0.0-0.5-0.50.5-0.5-0.7-0.10.3-0.30.3-0.4-1.6
Novelty place preference0.80.93.20.40.20.4-0.21.10.91.3-1.3-1.21.4-1.4-0.4-0.9-0.90.9-0.9-0.40.30.7-0.70.7-0.8-1.8
Time in novel zone, NPP test0.91.03.00.50.30.60.01.31.11.3-1.0-1.31.5-1.5-0.6-1.0-1.01.0-1.0-0.10.60.8-0.80.8-0.9-1.7
Total zone transitions, NPP test0.30.42.8-0.4-0.1-0.20.2-0.6-0.4-0.31.70.6-0.80.7-0.10.30.4-0.40.40.70.2-0.30.3-0.30.01.5
Total locomotion distance, NPP test0.10.10.5-0.7-0.6-0.5-0.6-0.10.1-0.4-0.2-0.10.0-0.4-0.3-0.5-0.40.4-0.40.00.30.3-0.30.3-0.6-0.0
Locomotion velocity, NPP test0.10.20.9-0.9-0.8-0.7-0.8-0.3-0.0-0.6-0.50.1-0.1-0.3-0.2-0.4-0.30.3-0.3-0.20.10.2-0.20.2-0.50.0
Intraocular pressure0.30.52.90.30.10.3-0.11.00.70.6-0.5-1.01.2-1.1-0.1-0.5-0.40.4-0.4-0.20.60.4-0.40.4-0.8-1.7
Delta distance traveled before/after self-admin4.24.58.4-0.5-0.3-0.2-0.31.72.3-0.1-1.5-2.22.1-2.6-2.8-2.6-2.92.9-2.91.82.62.6-2.62.6-2.7-0.6
Delta ambulatory time before/after self-admin3.74.68.8-0.7-0.2-0.2-0.21.72.30.1-1.3-2.22.1-2.5-2.8-2.7-3.03.0-3.01.82.52.7-2.72.7-2.7-0.3
Parametrial fat weight3.17.215.32.83.13.02.73.93.92.91.1-3.73.9-2.9-2.6-2.4-2.42.4-2.41.61.72.1-2.12.1-2.4-1.0
Pavlov. Cond. lever latency0.10.10.30.10.10.20.00.50.5-0.00.2-0.50.6-0.6-0.3-0.3-0.40.4-0.4-0.00.20.5-0.50.5-0.4-0.4
Pavlov. Cond. magazine entry latency0.20.30.9-0.9-0.9-0.9-0.9-0.5-0.5-0.5-0.90.4-0.30.00.2-0.1-0.10.1-0.1-0.6-0.2-0.10.1-0.1-0.1-0.4
Pavlov. Cond. change in total contacts0.10.10.3-0.4-0.3-0.5-0.2-0.3-0.2-0.6-0.40.2-0.30.2-0.1-0.1-0.10.1-0.10.30.2-0.10.1-0.1-0.20.4
Pavlov. Cond. index score0.10.10.5-0.4-0.3-0.4-0.4-0.3-0.3-0.2-0.70.3-0.30.20.20.00.0-0.00.0-0.4-0.3-0.20.2-0.2-0.0-0.0
Pavlov. Cond. latency score0.10.10.7-0.5-0.4-0.6-0.4-0.3-0.3-0.3-0.80.3-0.30.10.1-0.1-0.00.0-0.0-0.3-0.2-0.20.2-0.2-0.1-0.0
Pavlov. Cond. lever contacts0.30.40.80.00.0-0.20.1-0.6-0.70.1-0.00.7-0.80.90.60.60.7-0.70.7-0.3-0.6-0.80.8-0.80.60.5
Pavlov. Cond. magazine entry number0.20.20.90.50.50.40.6-0.00.00.31.00.1-0.20.40.20.60.6-0.60.60.4-0.0-0.20.2-0.20.60.7
Pavlov. Cond. intertrial magazine entries1.72.17.42.72.12.32.10.3-0.41.92.20.3-0.31.21.01.31.4-1.41.40.1-0.9-1.31.3-1.31.30.0
Pavlov. Cond. lever-magazine prob. diff.0.00.00.3-0.3-0.2-0.3-0.2-0.2-0.2-0.2-0.60.2-0.20.10.1-0.00.0-0.00.0-0.3-0.2-0.20.2-0.2-0.1-0.1
Pavlov. Cond. response bias0.10.20.3-0.4-0.4-0.5-0.4-0.5-0.6-0.3-0.40.5-0.50.40.40.20.2-0.20.2-0.5-0.5-0.50.5-0.50.1-0.0
Pavlov. Cond. lever latency0.50.73.8-1.1-1.4-1.1-1.6-0.2-0.3-0.5-1.9-0.10.2-0.80.2-0.5-0.50.5-0.5-1.00.00.3-0.30.3-0.4-1.7
Pavlov. Cond. magazine entry latency0.50.62.2-0.2-0.2-0.30.1-0.8-0.7-0.81.50.9-1.01.00.50.80.8-0.80.80.2-0.3-0.70.7-0.70.71.2
Pavlov. Cond. change in total contacts0.30.51.90.91.20.91.40.50.70.91.4-0.30.20.2-0.6-0.0-0.00.0-0.01.20.40.2-0.20.2-0.21.4
Pavlov. Cond. index score0.71.02.80.40.50.30.8-0.7-0.7-0.31.70.9-1.01.40.71.21.2-1.21.20.2-0.7-1.01.0-1.01.11.6
Pavlov. Cond. latency score0.50.72.30.00.1-0.10.4-0.8-0.6-0.61.50.9-1.01.20.50.90.9-0.90.90.3-0.4-0.70.7-0.70.81.5
Pavlov. Cond. lever contacts0.50.73.41.21.51.21.70.40.40.61.8-0.1-0.10.7-0.30.30.3-0.30.31.10.1-0.20.2-0.20.21.5
Pavlov. Cond. magazine entry number0.10.11.0-0.1-0.2-0.1-0.40.0-0.20.4-1.00.00.1-0.10.3-0.0-0.00.0-0.0-0.7-0.5-0.20.2-0.20.1-0.8
Pavlov. Cond. intertrial magazine entries0.20.20.90.90.70.70.70.2-0.00.10.70.0-0.00.30.30.50.5-0.50.5-0.1-0.5-0.50.5-0.50.40.1
Pavlov. Cond. lever-magazine prob. diff.0.70.92.90.30.40.10.7-0.8-0.7-0.41.71.0-1.11.40.61.11.1-1.11.10.2-0.7-1.01.0-1.01.11.7
Pavlov. Cond. response bias0.60.83.61.11.41.11.60.10.20.41.90.1-0.20.90.00.70.7-0.70.70.8-0.2-0.50.5-0.50.51.6
Time in closed arm before self-admin0.30.41.70.50.60.50.70.60.70.61.3-0.50.4-0.3-0.7-0.5-0.50.5-0.51.11.00.2-0.20.2-0.70.4
Time in closed arm after self-admin8.59.115.2-0.00.40.80.22.93.60.5-1.2-3.53.4-3.9-3.5-3.9-3.73.7-3.72.43.53.8-3.83.8-3.8-1.2
Time in open arm before self-admin0.00.00.3-0.2-0.2-0.2-0.2-0.20.2-0.6-0.5-0.00.0-0.2-0.1-0.1-0.10.1-0.1-0.0-0.20.1-0.10.1-0.00.3
Time in open arm after self-admin1.71.93.40.90.90.71.0-0.7-1.11.11.51.2-1.21.81.31.81.6-1.61.6-0.5-1.4-1.81.8-1.81.70.9
Bone: periosteal estimation0.71.45.02.12.12.12.21.11.01.91.7-0.80.70.1-1.0-0.5-0.50.5-0.51.30.30.1-0.10.1-0.31.0
Bone: periosteal perimeter0.50.93.41.21.41.11.6-0.1-0.10.71.80.4-0.61.2-0.00.50.5-0.50.50.6-0.6-0.80.8-0.80.71.8
Bone: post-yield work0.60.82.31.21.21.01.20.0-0.21.50.40.3-0.20.90.61.00.9-0.90.9-0.3-1.1-1.01.0-1.01.10.6
Progressive ratio test 1 active lever presses1.01.25.8-2.4-2.0-2.2-1.9-1.4-1.1-1.6-1.41.0-1.00.30.40.10.0-0.00.0-0.60.00.1-0.10.1-0.20.1
Progressive ratio test 1 breakpoint0.91.15.5-2.3-1.9-2.1-1.8-1.3-1.0-1.6-1.31.0-0.90.30.30.1-0.00.0-0.0-0.40.10.1-0.10.1-0.30.1
Progressive ratio test 1 inactive lever presses1.52.25.2-2.0-2.3-2.1-2.2-2.0-2.0-1.9-1.61.7-1.60.81.50.90.9-0.90.9-1.6-1.0-0.90.9-0.90.8-0.5
Progressive ratio test 2 active lever presses2.83.36.2-2.1-2.4-2.3-2.2-2.5-2.5-2.1-1.02.3-2.21.52.01.81.6-1.61.6-1.7-1.3-1.11.1-1.11.30.1
Progressive ratio test 2 breakpoint2.83.25.9-2.0-2.3-2.2-2.1-2.4-2.4-2.0-0.92.2-2.21.52.01.81.7-1.71.7-1.7-1.3-1.11.1-1.11.40.1
Progressive ratio test 2 inactive lever presses4.16.714.5-2.0-2.3-2.4-1.8-3.6-3.6-2.70.23.6-3.83.12.52.72.6-2.62.6-1.3-1.7-2.52.5-2.52.31.7
Incentive Sensitization - Responses1.82.55.0-1.0-1.3-1.0-1.1-2.1-2.2-1.40.22.1-2.21.72.02.01.9-1.91.9-1.2-1.3-1.31.3-1.31.70.3
Incentive Sensitization - Breakpoint2.32.95.8-1.0-1.4-1.1-1.2-2.2-2.4-1.50.32.3-2.31.92.12.12.0-2.02.0-1.2-1.4-1.51.5-1.51.80.4
Sum of active levers in priming session hrs 5-61.71.54.00.20.0-0.20.0-1.1-1.3-0.60.71.3-1.21.51.51.51.5-1.51.5-1.4-2.0-1.51.5-1.51.50.4
Progressive ratio0.20.41.31.10.60.70.50.3-0.11.10.1-0.00.20.20.60.70.6-0.60.6-0.5-0.5-0.70.7-0.70.4-0.5
Food seeking constrained by brief footshock0.60.72.7-1.2-1.1-1.3-1.3-0.7-0.6-0.7-1.40.5-0.30.10.90.40.4-0.40.4-1.7-1.2-0.40.4-0.40.5-0.6
Seeking ratio, punishment vs. effort0.30.51.9-1.4-1.1-1.1-1.2-0.6-0.4-1.3-1.00.3-0.2-0.20.2-0.2-0.20.2-0.2-0.8-0.30.4-0.40.40.1-0.4
Retroperitoneal fat weight1.56.411.52.83.03.02.93.33.42.81.9-3.13.0-2.1-2.6-2.3-2.12.1-2.12.62.22.1-2.12.1-2.2-0.1
Reaction time number correct0.20.41.00.20.30.00.4-0.4-0.50.30.50.6-0.70.90.61.00.9-0.90.90.0-0.4-0.60.6-0.60.90.8
Reaction time mean minus median0.51.32.3-0.4-0.9-0.9-0.7-1.3-1.4-1.50.01.3-1.41.11.11.31.3-1.31.3-0.7-0.8-1.51.5-1.51.20.4
Reaction time mean minus median AUC0.71.83.60.2-0.3-0.4-0.1-1.4-1.5-1.00.61.6-1.71.61.21.61.5-1.51.5-0.4-1.0-1.91.9-1.91.61.0
Reaction time num false alarms1.31.84.7-1.8-1.8-1.8-2.0-1.2-1.1-1.9-2.20.9-0.60.11.50.91.0-1.01.0-2.0-1.4-0.90.9-0.90.6-0.9
Reaction time num false alarms AUC1.01.54.8-2.0-1.9-2.0-2.0-1.0-0.8-1.9-2.20.6-0.4-0.21.20.70.8-0.80.8-1.8-1.0-0.50.5-0.50.4-0.8
Reaction time trials correct on left0.20.41.00.20.30.00.4-0.4-0.50.30.50.6-0.70.90.61.00.9-0.90.90.0-0.4-0.60.6-0.60.90.8
Reaction time trials on left0.20.41.00.20.30.10.4-0.4-0.50.30.50.6-0.70.90.61.00.9-0.90.90.0-0.4-0.60.6-0.60.90.8
Reaction time mean0.20.32.30.5-0.00.3-0.30.60.4-0.4-1.1-0.60.8-0.9-0.2-0.5-0.50.5-0.5-0.40.20.1-0.10.1-0.4-1.5
Reaction time mean AUC0.10.21.20.4-0.10.1-0.30.1-0.2-0.5-0.7-0.10.2-0.30.30.10.1-0.10.1-0.7-0.3-0.40.4-0.40.2-1.1
Median of all reaction times0.81.24.00.70.30.7-0.01.31.10.1-1.3-1.41.5-1.6-0.8-1.2-1.21.2-1.2-0.00.70.9-0.90.9-1.1-2.0
Reaction time omissions0.00.10.40.1-0.30.1-0.30.20.1-0.0-0.3-0.20.1-0.4-0.2-0.2-0.10.1-0.10.30.60.2-0.20.2-0.0-0.5
Reaction time false alarm rate1.01.36.0-1.9-1.9-1.8-2.1-0.7-0.5-1.9-2.40.3-0.0-0.60.80.10.2-0.20.2-1.7-0.8-0.10.1-0.1-0.1-1.2
Reaction time premature initiation rate1.11.52.91.21.31.01.31.31.41.01.6-1.21.1-0.8-1.7-1.2-1.31.3-1.31.61.31.1-1.11.1-0.90.4
Reaction time premature initiations0.40.73.61.21.20.81.40.60.71.01.9-0.40.30.1-0.9-0.2-0.40.4-0.41.20.70.3-0.30.3-0.01.0
Std. dev. reaction times0.50.91.8-0.4-1.0-0.9-1.0-0.9-1.1-1.4-0.90.9-0.90.51.00.90.9-0.90.9-1.1-0.8-1.11.1-1.10.9-0.4
Reaction time trials completed0.20.41.00.20.30.10.4-0.4-0.50.30.50.6-0.70.90.61.00.9-0.90.90.0-0.4-0.60.6-0.60.90.8
Reaction time trials AUC0.20.40.90.50.60.40.7-0.1-0.30.70.60.4-0.50.80.61.00.9-0.90.90.1-0.4-0.60.6-0.60.80.7
Run reversals in cocaine runway, females0.50.53.1-0.8-1.1-0.9-0.9-1.1-0.9-1.8-0.50.9-1.00.40.30.30.3-0.30.30.20.3-0.20.2-0.20.30.4
Run reversals in cocaine runway, males0.60.62.8-0.00.1-0.20.4-0.9-0.7-0.41.11.0-1.11.20.30.80.8-0.80.80.4-0.4-0.50.5-0.50.81.7
Latency to leave start box in cocaine runway0.50.61.5-0.0-0.1-0.2-0.10.60.7-0.4-0.6-0.70.6-0.8-1.0-0.9-0.90.9-0.90.60.91.2-1.21.2-0.7-0.2
Latency to leave start box in cocaine runway, F1.01.12.4-0.2-0.4-0.2-0.60.81.0-0.5-1.3-1.11.1-1.6-1.0-1.2-1.21.2-1.20.31.11.5-1.51.5-1.0-1.1
Latency to leave start box in cocaine runway, M0.20.21.70.20.40.00.6-0.3-0.2-0.01.00.4-0.50.7-0.30.10.1-0.10.10.70.10.1-0.10.10.21.3
Std. dev. time between licks in bursts1.21.62.7-0.6-0.7-0.7-0.5-1.5-1.6-1.00.61.6-1.61.61.31.31.3-1.31.3-0.9-1.3-1.51.5-1.51.40.7
Total sessions with >9 infusions0.30.41.8-0.9-0.9-0.6-1.1-0.1-0.1-0.7-1.3-0.10.3-0.60.3-0.1-0.20.2-0.2-0.60.20.3-0.30.3-0.3-1.3
Short access day 1 total inactive lever presses1.21.63.2-0.9-1.5-1.2-1.6-1.4-1.7-1.0-1.11.3-1.20.71.61.11.1-1.11.1-1.8-1.2-1.31.3-1.31.2-1.0
Short access day 10 total inactive lever presses0.10.31.60.7-0.00.7-0.10.1-0.40.6-0.00.1-0.1-0.00.80.70.7-0.70.7-0.5-0.1-0.40.4-0.40.4-1.2
Short access day 1 total infusions0.50.73.8-0.9-1.0-0.5-1.30.20.2-0.6-1.9-0.50.8-1.10.4-0.2-0.40.4-0.4-1.0-0.00.7-0.70.7-0.5-1.9
Short access day 10 total infusions0.60.83.1-0.7-0.7-0.4-0.90.60.50.1-1.5-0.81.0-1.2-0.3-0.7-0.90.9-0.9-0.50.60.9-0.90.9-1.0-1.8
Short access total infusions0.50.62.6-0.9-0.9-0.6-1.10.30.2-0.3-1.5-0.50.7-1.00.0-0.4-0.50.5-0.5-0.50.50.8-0.80.8-0.7-1.6
Short access day 1 locomotion0.81.05.0-1.2-1.7-1.2-1.9-0.4-0.5-1.2-2.20.10.2-0.80.70.0-0.00.0-0.0-1.4-0.20.4-0.40.4-0.2-1.9
Short access day 10 total locomotion0.10.20.6-0.2-0.1-0.1-0.00.00.2-0.10.0-0.1-0.0-0.1-0.8-0.6-0.60.6-0.60.70.80.5-0.50.5-0.50.4
Short access total locomotion0.10.10.5-0.5-0.7-0.5-0.6-0.2-0.2-0.6-0.60.1-0.1-0.2-0.1-0.1-0.10.1-0.10.10.50.1-0.10.1-0.2-0.3
One hour access (0.3 mA shock)2.52.96.3-1.6-1.7-1.5-1.3-2.4-2.4-1.70.32.3-2.51.91.71.71.7-1.71.7-0.6-0.8-1.71.7-1.71.51.0
Compulsive drug intake0.40.51.21.01.01.01.00.90.90.50.8-0.80.7-0.5-0.7-0.7-0.50.5-0.51.10.80.4-0.40.4-0.30.3
One hour access (shock baseline)2.94.48.7-1.8-2.0-1.9-1.8-2.8-3.0-1.7-0.32.8-2.82.32.42.32.2-2.22.2-1.7-1.7-2.02.0-2.01.90.4
Social response proportion0.30.41.9-0.9-1.0-1.4-1.0-0.7-0.5-1.2-0.80.5-0.50.20.20.10.3-0.30.3-0.5-0.20.1-0.10.1-0.00.1
Social responses0.20.31.9-1.0-0.9-1.4-0.8-0.4-0.1-0.8-0.90.2-0.2-0.0-0.2-0.1-0.00.0-0.0-0.20.10.4-0.40.4-0.30.5
Social time0.10.11.10.20.20.10.4-0.0-0.00.51.00.1-0.20.4-0.3-0.1-0.00.0-0.00.60.4-0.10.1-0.10.10.6
Soleus weight0.51.65.21.62.01.72.11.21.31.92.3-0.90.8-0.0-1.3-0.6-0.70.7-0.71.70.80.5-0.50.5-0.51.2
Bone: stiffness0.10.20.70.30.20.10.2-0.4-0.40.70.10.5-0.50.60.30.30.3-0.30.3-0.4-0.8-0.70.7-0.70.50.5
Tibialis anterior weight3.612.333.45.85.65.85.24.94.15.32.4-4.14.1-2.2-2.5-1.9-1.91.9-1.92.61.81.8-1.81.8-1.9-1.2
Time to tail flick, vehicle, before self-admin1.92.06.9-0.9-1.1-0.9-1.4-1.1-1.4-0.9-1.41.1-0.70.62.21.51.5-1.51.5-2.6-2.1-1.21.2-1.21.3-1.3
Time to tail flick, vehicle, after self-admin0.81.13.61.20.91.21.00.91.10.51.0-1.00.8-0.8-1.3-1.1-0.90.9-0.91.91.60.9-0.90.9-0.90.2
Time to tail flick, test, before self-admin1.61.73.5-1.5-1.6-1.3-1.60.10.6-1.9-1.7-0.60.6-1.5-1.2-1.4-1.61.6-1.60.21.21.3-1.31.3-1.3-0.8
Time to tail flick, test, after self-admin0.90.91.8-1.1-0.9-0.9-0.70.00.6-1.0-1.0-0.50.3-0.9-1.2-1.3-1.11.1-1.11.01.31.1-1.11.1-1.20.4
Delta time to tail flick, vehicle, before/after SA1.91.87.51.31.21.21.41.01.20.91.7-1.00.5-0.5-1.9-1.3-1.21.2-1.22.72.21.0-1.01.0-1.01.1
Delta time to tail flick, test, before/after SA0.10.10.30.10.20.00.3-0.2-0.30.50.40.3-0.40.50.20.20.3-0.30.30.2-0.1-0.20.2-0.20.20.5
Tibia length0.00.10.9-0.0-0.3-0.2-0.3-0.3-0.10.3-0.90.1-0.2-0.00.0-0.0-0.00.0-0.00.10.10.0-0.00.0-0.20.0
Ambulatory time before self-admin0.60.82.01.00.81.00.9-0.3-0.60.21.40.6-0.61.00.90.81.0-1.01.0-0.3-0.9-1.31.3-1.30.80.3
Ambulatory time after self-admin1.11.32.20.60.70.90.61.41.40.50.0-1.41.5-1.3-1.4-1.5-1.51.5-1.50.81.00.9-0.90.9-1.5-0.6
Bone: tissue strength0.20.20.7-0.8-0.8-0.8-0.8-0.5-0.2-0.2-0.20.2-0.2-0.1-0.2-0.4-0.50.5-0.5-0.00.20.2-0.20.2-0.2-0.0
Total heroin consumption1.31.53.6-0.9-0.8-1.3-0.4-1.7-1.4-1.20.51.7-1.81.80.71.11.1-1.11.1-0.2-0.9-1.21.2-1.20.91.9
Bone: trabecular number0.30.51.00.30.30.40.20.80.90.3-0.2-0.90.9-0.9-0.7-0.7-0.80.8-0.80.50.71.0-1.01.0-0.7-0.4
Bone: trabecular spacing1.21.65.4-2.3-2.3-2.2-2.1-1.8-1.4-2.3-1.01.3-1.50.50.40.20.2-0.20.2-0.20.3-0.20.2-0.20.30.4
Bone: trabecular thickness0.50.62.01.41.31.21.21.10.91.30.2-0.91.0-0.4-0.4-0.3-0.30.3-0.30.3-0.00.3-0.30.3-0.4-0.3
Bone: trabecular tissue density0.50.72.7-1.7-1.4-1.5-1.3-0.8-0.3-1.0-0.70.4-0.5-0.1-0.6-0.9-0.90.9-0.9-0.10.20.4-0.40.4-0.70.4
Water consumed over 24 hours0.50.71.1-1.0-0.8-1.0-0.7-1.0-1.0-0.8-0.21.0-0.90.90.70.70.7-0.70.7-0.9-1.0-0.80.8-0.80.80.6
Number of responses in last shaping day1.01.14.1-1.8-1.9-1.7-1.9-0.7-0.3-2.0-1.80.2-0.1-0.8-0.1-0.3-0.50.5-0.5-0.30.60.7-0.70.7-0.6-0.6