Hub : Genes

Dop1b

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Liver gene expression Dop1b 0.08 0.05 3.8e-10 0.07 0.07 0.06 0.07 1.5e-08 5.5e-08 6.9e-07 5.6e-08
2 OFC gene expression Dop1b 0.16 0.1 3.1e-03 0.12 0.09 0.08 0.09 7.8e-04 3.7e-03 6.0e-03 4.2e-03
3 NAcc gene expression Dop1b 0.13 0.08 1.0e-10 0.09 0.09 0.08 0.09 1.1e-10 2.8e-10 1.7e-09 2.4e-10
4 PL gene expression Dop1b 0.05 0.03 8.8e-07 0.05 0.06 0.06 0.06 2.2e-06 1.2e-07 2.0e-07 4.2e-07
5 Adipose gene expression Dop1b 0.13 0.07 7.4e-08 0.06 0.05 0.04 0.06 9.5e-08 3.5e-06 1.4e-05 1.3e-07
6 PL mRNA stability Dop1b 0.08 0.04 2.5e-07 0.06 0.07 0.07 0.07 2.5e-07 5.3e-08 7.8e-08 2.8e-08
7 BLA gene expression Dop1b 0.08 0.05 5.8e-04 0.03 0.04 0.02 0.04 1.2e-02 4.8e-03 2.0e-02 3.2e-03
8 Brain mRNA stability Dop1b 0.07 0.04 2.9e-04 0.01 0.02 0.01 0.02 1.4e-02 2.5e-03 2.5e-02 4.8e-03
9 Brain gene expression Dop1b 0.17 0.09 8.2e-10 0.08 0.1 0.1 0.1 1.3e-07 2.9e-09 1.3e-09 3.8e-09
10 Adipose alternative polyA XM_039088417.1 0.11 0.06 1.2e-06 0.07 0.06 0.06 0.06 6.1e-08 1.2e-07 1.2e-07 1.1e-07
11 Adipose alternative polyA XM_039088419.1 0.11 0.06 1.5e-06 0.07 0.06 0.06 0.06 6.0e-08 1.4e-07 1.3e-07 1.1e-07
12 PL intron excision ratio chr11_33119833_33121742 0.06 0.04 1.1e-03 0.04 0.02 0.03 0.03 7.1e-05 1.5e-03 7.0e-04 5.1e-04
13 Adipose isoform ratio XM_039088419.1 0.09 0.05 1.5e-05 0.04 0.05 0.04 0.04 2.8e-05 6.6e-06 1.5e-05 1.0e-05
14 PL intron excision ratio chr11_33119833_33121812 0.04 0.03 7.1e-03 0.03 0.01 0.01 0.02 4.8e-04 2.2e-02 2.0e-02 6.5e-03
15 Brain isoform ratio NM_001191660.2 0.09 0.05 2.6e-04 0.06 0.04 0.05 0.05 5.7e-06 1.7e-04 2.8e-05 1.7e-05
16 Brain intron excision ratio chr11_33094446_33095804 0.06 0.04 3.8e-03 0.04 0.03 0.04 0.04 6.8e-05 2.0e-03 1.2e-04 1.4e-04
17 Adipose mRNA stability Dop1b 0.06 0.04 4.8e-04 0.02 0.02 0.02 0.02 1.0e-03 1.0e-03 1.4e-03 5.2e-03
18 Brain intron excision ratio chr11_33073663_33075216 0.05 0.03 8.9e-03 0.01 0.02 0.02 0.01 6.5e-02 8.4e-03 1.1e-02 1.5e-02
19 Brain intron excision ratio chr11_33073712_33075216 0.06 0.04 2.5e-03 0.01 0.03 0.03 0.02 1.5e-02 9.7e-04 1.1e-03 2.5e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19
Bone: apparent density0.30.51.1-0.00.00.4-0.30.90.4-0.00.80.30.7-0.7-0.71.00.80.80.80.71.0-1.0
Area under the delay curve1.21.33.10.10.1-1.0-0.10.00.60.61.0-0.51.6-1.6-1.61.51.61.61.61.8-0.20.2
BMI with tail0.51.82.8-1.1-0.9-1.51.2-0.51.41.31.6-1.41.6-1.6-1.61.21.71.71.71.4-0.40.3
BMI without tail0.20.30.70.00.20.1-0.20.30.0-0.10.4-0.40.8-0.8-0.80.70.80.80.80.80.5-0.5
Body weight0.20.71.2-0.9-0.6-1.10.9-0.41.10.81.1-0.90.8-0.8-0.80.81.01.01.01.0-0.40.3
Weight adjusted by age0.60.61.81.41.10.5-1.10.9-1.1-1.1-0.61.3-0.60.60.6-0.0-0.6-0.6-0.6-0.3-0.30.4
Bone surface2.03.58.1-2.6-2.5-2.92.8-2.22.62.71.7-2.61.1-1.1-1.10.51.21.21.21.1-0.80.6
Bone volume1.11.93.9-1.7-1.7-1.81.8-1.12.01.91.6-1.71.1-1.1-1.10.81.21.21.21.2-0.10.0
Breakpoint value in progressive ratio session0.40.41.50.40.2-0.60.1-1.2-0.6-0.3-0.8-0.7-0.30.30.3-0.6-0.3-0.3-0.3-0.3-1.21.2
Number of licking bursts0.80.92.30.70.81.0-1.11.5-0.0-0.60.61.40.8-0.8-0.81.10.70.70.70.71.3-1.3
Context. condit. distance diff. score0.50.63.50.60.3-0.90.3-1.1-0.40.2-0.8-0.6-0.10.10.1-0.8-0.2-0.2-0.2-0.4-1.91.9
Locomotion velocity, session 10.10.10.3-0.2-0.20.10.1-0.20.10.0-0.20.4-0.30.30.3-0.4-0.4-0.4-0.4-0.50.1-0.1
Locomotion distance, session 10.60.82.5-0.6-0.8-1.21.0-1.60.40.8-0.4-0.8-0.60.60.6-0.9-0.7-0.7-0.7-0.6-1.31.3
Locomotion velocity, session 20.50.61.2-0.2-0.3-0.60.5-0.9-0.20.1-0.6-0.4-1.01.01.0-0.9-0.8-0.8-0.8-0.7-1.11.1
Locomotion distance, session 20.10.10.30.30.1-0.50.0-0.10.10.10.1-0.10.3-0.3-0.30.30.40.40.40.5-0.50.5
Locomotion velocity, session 32.73.18.9-2.3-2.4-2.02.5-3.01.22.0-0.4-2.0-1.51.51.5-1.8-1.3-1.3-1.3-1.3-1.31.2
Locomotion distance, session 30.60.62.0-1.1-1.2-0.70.9-0.61.41.41.0-0.10.5-0.5-0.50.40.50.50.50.50.5-0.6
Stereotopy head waving bouts, day 31.11.33.7-1.2-1.10.90.20.40.3-0.2-0.10.3-1.41.41.4-0.8-1.3-1.3-1.3-1.41.9-1.9
Stereotopy head waving duration, day 30.70.92.1-0.9-1.00.70.30.20.3-0.2-0.10.1-1.21.21.2-0.8-1.1-1.1-1.1-1.21.4-1.5
Locomotion velocity, session 70.60.72.21.41.31.1-1.20.8-1.0-1.1-0.81.5-0.30.30.3-0.2-0.4-0.4-0.4-0.50.1-0.1
Locomotion distance, session 70.60.82.41.61.40.8-1.41.0-0.8-0.9-0.21.50.6-0.6-0.60.70.50.50.50.5-0.00.1
Stereotopy head waving bouts, day 71.72.04.2-1.2-1.3-0.51.4-1.50.10.6-0.9-0.9-1.71.71.7-2.1-1.8-1.8-1.8-1.9-0.70.6
Stereotopy head waving duration, day 72.22.75.4-1.4-1.3-1.31.8-2.30.10.8-1.1-1.7-1.61.61.6-2.3-1.8-1.8-1.8-1.9-1.71.7
Locomotion velocity, session 81.82.25.9-2.1-1.9-1.82.2-2.41.01.7-0.2-1.3-1.11.11.1-1.5-1.1-1.1-1.1-1.1-1.41.3
Locomotion distance, session 80.40.63.70.60.2-1.10.4-1.2-0.20.3-0.5-0.5-0.10.10.1-0.50.00.00.0-0.1-1.91.9
Degree of sensitization distance0.90.92.81.61.71.0-1.50.9-1.5-1.5-0.91.1-0.20.20.2-0.1-0.2-0.2-0.2-0.4-0.50.5
Degree of sensitization stereotypy1.81.95.1-1.4-1.5-1.72.0-2.30.61.3-0.5-1.7-0.90.90.9-1.6-1.0-1.0-1.0-1.1-1.71.6
Conditioned locomotion0.40.51.51.11.00.8-1.00.7-1.2-1.1-0.80.3-0.50.50.5-0.3-0.5-0.5-0.5-0.5-0.10.2
Cocaine response after cond. corrected0.91.12.10.10.4-0.20.0-0.9-0.8-0.2-1.3-0.3-1.11.11.1-1.4-1.3-1.3-1.3-1.3-1.31.3
Cocaine response after cond. not corrected1.01.12.10.40.7-0.2-0.2-0.8-0.9-0.4-1.4-0.2-1.11.11.1-1.4-1.3-1.3-1.3-1.3-1.41.4
Cocaine response before conditioning0.10.10.10.30.2-0.3-0.1-0.00.0-0.20.0-0.30.3-0.3-0.30.20.30.30.30.3-0.30.3
Saline control response0.40.61.6-0.6-0.8-0.90.9-1.30.10.5-0.4-1.1-0.60.60.6-0.8-0.6-0.6-0.6-0.6-0.80.8
Bone: connectivity density0.50.81.6-0.9-1.0-0.80.8-0.21.31.11.2-0.60.9-0.9-0.90.81.01.01.00.90.4-0.5
Bone: cortical apparent density0.10.10.30.10.00.0-0.10.40.2-0.10.50.10.5-0.5-0.50.50.50.50.50.50.3-0.3
Bone: cortical area0.40.61.8-0.10.1-0.70.5-1.0-0.3-0.1-0.8-0.9-0.90.90.9-1.0-0.7-0.7-0.7-0.7-1.31.3
Bone: cortical porosity0.20.30.80.70.70.8-0.90.8-0.7-0.8-0.40.3-0.20.20.20.20.00.00.0-0.00.4-0.4
Bone: cortical porosity0.20.20.70.70.80.5-0.80.7-0.6-0.7-0.30.10.0-0.0-0.00.30.30.30.30.20.2-0.1
Bone: cortical thickness1.72.95.52.02.21.4-1.70.6-2.3-2.2-2.20.7-1.81.81.8-1.4-1.6-1.6-1.6-1.6-0.91.0
Bone: cortical thickness0.30.41.31.11.10.9-1.00.9-0.8-0.9-0.40.5-0.10.10.10.2-0.0-0.0-0.00.00.2-0.2
Bone: cortical tissue density0.10.20.40.1-0.1-0.00.00.40.30.00.60.10.6-0.6-0.60.60.60.60.60.60.3-0.3
Condit. Reinf. active minus inactive responses0.00.00.10.10.10.1-0.10.1-0.3-0.1-0.3-0.2-0.00.00.0-0.1-0.1-0.1-0.1-0.10.0-0.0
Condit. Reinf. active-inactive response ratio0.40.40.70.70.60.5-0.50.2-0.8-0.6-0.80.4-0.80.80.8-0.6-0.7-0.7-0.7-0.7-0.20.2
Condit. Reinf. active responses0.10.10.6-0.1-0.1-0.40.1-0.2-0.10.1-0.2-0.80.3-0.3-0.3-0.10.20.20.20.1-0.30.3
Condit. Reinf. inactive responses0.10.10.6-0.5-0.4-0.40.3-0.50.20.3-0.0-0.80.1-0.1-0.1-0.1-0.0-0.0-0.0-0.1-0.10.1
Incentive salience index mean0.00.00.20.50.40.2-0.30.2-0.4-0.3-0.3-0.10.0-0.0-0.00.00.10.10.10.1-0.10.2
Condit. Reinf. lever presses0.20.31.01.00.80.3-0.50.2-0.8-0.6-0.7-0.0-0.30.30.3-0.3-0.2-0.2-0.2-0.2-0.60.7
Condit. Reinf. active minus inactive responses0.81.03.5-0.5-0.6-1.71.1-1.60.41.0-0.1-1.60.1-0.1-0.1-0.40.20.20.20.2-1.91.8
Condit. Reinf. active-inactive response ratio0.80.81.6-0.1-0.1-1.00.3-0.20.50.50.7-0.91.2-1.2-1.20.91.21.21.21.3-0.70.7
Condit. Reinf. active responses1.11.54.3-1.0-1.1-1.61.5-2.10.31.1-0.6-1.6-0.90.90.9-1.4-0.8-0.8-0.8-0.9-1.81.7
Condit. Reinf. inactive responses1.51.83.5-1.0-1.0-0.81.2-1.9-0.00.6-0.9-1.0-1.71.71.7-1.9-1.6-1.6-1.6-1.7-1.21.1
Condit. Reinf. lever presses0.50.62.0-0.5-0.7-1.11.1-1.40.30.7-0.2-1.0-0.30.30.3-0.8-0.4-0.4-0.4-0.4-1.31.3
Condit. Reinf. lever reinforcers received1.11.64.9-1.1-1.2-1.81.6-2.20.51.3-0.5-1.7-0.70.70.7-1.3-0.7-0.7-0.7-0.7-1.91.8
Conditioned reinforcement - actives0.30.31.31.11.10.0-0.3-0.8-0.4-0.5-0.20.40.4-0.4-0.40.20.10.10.10.3-1.01.1
Conditioned reinforcement - inactives1.71.94.62.11.81.5-1.40.0-1.9-1.6-2.11.3-1.01.01.0-1.4-1.2-1.2-1.2-1.3-0.80.9
Conditioned locomotion0.20.31.01.00.80.8-0.80.2-0.7-0.8-0.60.0-0.20.20.2-0.1-0.3-0.3-0.3-0.20.4-0.3
Patch foraging indifference point 0 sec2.74.47.61.81.71.4-1.20.1-2.1-1.6-2.51.5-2.82.82.8-2.4-2.6-2.6-2.6-2.6-1.21.2
Patch foraging indifference point AUC1.41.65.1-1.3-1.2-1.41.6-2.30.10.8-0.6-1.3-1.01.01.0-1.5-1.1-1.1-1.1-0.9-1.71.7
Delay disc. indifference point, 0s delay1.31.43.2-0.3-0.4-1.20.5-0.10.80.61.0-0.81.7-1.7-1.71.11.81.81.81.7-0.60.6
Delay disc. indifference point, 16s delay0.80.81.8-0.1-0.1-0.0-0.30.70.60.41.0-0.11.2-1.2-1.21.31.21.21.21.30.9-0.9
Delay disc. indifference point, 2s delay1.21.32.8-0.3-0.2-0.80.30.31.20.91.4-0.41.5-1.5-1.51.51.61.61.61.70.2-0.2
Delay disc. indifference point, 24s delay0.50.51.10.70.80.2-0.90.5-0.7-0.5-0.1-0.20.8-0.8-0.80.70.90.90.91.0-0.10.2
Delay disc. indifference point, 4s delay1.11.22.5-0.6-0.5-1.50.4-0.10.70.81.1-1.11.3-1.3-1.31.31.41.41.41.6-0.50.5
Delay disc. indifference point, 8s delay0.40.40.80.60.7-0.4-0.50.3-0.00.10.20.10.9-0.9-0.90.80.80.80.80.8-0.40.4
Indifference point function ln k0.50.72.81.71.51.1-1.51.0-1.3-1.2-0.90.2-0.10.10.10.0-0.1-0.1-0.1-0.20.3-0.2
Indifference point function log k0.50.72.81.71.51.1-1.51.0-1.3-1.2-0.90.2-0.10.10.10.0-0.1-0.1-0.1-0.20.3-0.2
Patch foraging total patch changes 0 sec2.33.76.91.51.41.0-0.9-0.1-1.8-1.3-2.31.1-2.62.62.6-2.3-2.4-2.4-2.4-2.5-1.31.3
Patch foraging total patch changes 12 sec1.72.23.9-0.8-0.9-0.71.0-1.7-0.40.3-1.2-0.9-2.02.02.0-2.0-2.0-2.0-2.0-1.8-1.31.3
Patch foraging total patch changes 18 sec1.72.14.3-0.3-0.1-0.40.9-1.9-0.40.2-1.4-0.9-1.91.91.9-2.1-1.7-1.7-1.7-1.6-1.81.8
Patch foraging total patch changes 24 sec1.01.24.1-0.4-0.4-1.31.1-1.8-0.10.7-0.8-1.4-0.80.80.8-1.2-0.7-0.7-0.7-0.8-2.02.0
Patch foraging total patch changes 6 sec2.84.18.6-0.1-0.00.30.6-1.7-0.9-0.4-2.00.4-2.92.92.9-2.8-2.9-2.9-2.9-2.8-1.41.4
Patch foraging time to switch 0 sec0.61.02.0-0.2-0.20.2-0.00.91.00.41.40.51.1-1.1-1.11.41.21.21.21.21.2-1.2
Patch foraging water rate 0 sec0.81.23.1-0.8-1.0-0.71.3-1.80.61.1-0.6-0.2-1.21.21.2-1.6-1.2-1.2-1.2-1.3-0.80.7
Patch foraging water rate 12 sec1.32.04.82.22.11.3-1.30.4-1.6-1.4-1.71.8-1.21.21.2-1.3-1.3-1.3-1.3-1.3-1.01.1
Patch foraging water rate 18 sec0.20.30.8-0.2-0.5-0.40.6-0.30.90.80.80.20.5-0.5-0.50.60.40.40.40.40.3-0.3
Patch foraging water rate 24 sec0.30.41.61.31.2-0.2-0.4-0.7-0.5-0.2-0.70.2-0.20.20.2-0.3-0.2-0.2-0.2-0.1-1.21.2
Patch foraging water rate 6 sec0.10.20.40.70.5-0.0-0.1-0.60.10.3-0.50.7-0.40.40.4-0.5-0.2-0.2-0.2-0.3-0.70.7
Seeking ratio, delayed vs. immediate footshock1.61.83.60.30.31.3-0.81.90.50.11.31.81.5-1.5-1.51.61.41.41.41.11.9-1.9
Distance traveled before self-admin0.20.21.1-0.1-0.3-0.50.4-1.0-0.2-0.3-0.3-1.00.1-0.1-0.1-0.20.10.10.10.3-0.80.8
Distance traveled after self-admin1.21.43.0-0.3-0.5-0.20.10.71.10.41.50.11.6-1.6-1.61.61.51.51.51.70.9-0.9
Extensor digitorum longus weight1.97.420.2-4.5-4.5-3.34.1-2.74.23.82.9-3.11.4-1.4-1.40.71.41.41.41.40.5-0.7
Bone: elastic displacement0.30.41.00.50.61.0-1.01.0-0.4-0.7-0.10.6-0.10.10.10.3-0.0-0.0-0.0-0.01.0-1.0
Bone: elastic work0.10.20.3-0.10.20.5-0.30.2-0.2-0.3-0.4-0.2-0.60.60.6-0.4-0.5-0.5-0.5-0.50.5-0.5
Bone: endosteal estimation2.76.011.0-3.0-3.1-3.23.1-2.03.33.32.7-2.32.3-2.3-2.31.52.12.12.12.1-0.20.0
Bone: endosteal perimeter1.32.78.8-2.1-2.2-3.02.5-2.51.82.20.9-2.30.7-0.7-0.7-0.10.60.60.60.6-1.61.5
Epididymis fat weight2.96.716.0-3.4-3.3-4.03.6-2.93.33.42.3-3.51.8-1.8-1.80.91.81.81.81.9-1.51.3
Delta time in closed arm before/after self-admin1.01.02.20.0-0.1-0.1-0.11.00.4-0.01.30.41.3-1.3-1.31.51.41.41.41.40.6-0.6
Delta time in open arm before/after self-admin0.30.21.1-0.5-0.7-0.30.6-0.61.01.10.4-0.40.4-0.4-0.40.00.10.10.10.10.2-0.2
Diff in mean of infusions in LGA sessions1.92.15.0-0.4-0.5-1.01.1-2.1-0.50.2-1.7-1.3-1.41.41.4-2.2-1.5-1.5-1.5-1.5-2.12.1
Delay discount exponential model param1.01.12.7-0.1-0.21.00.2-0.0-0.5-0.6-0.90.5-1.41.41.4-1.4-1.5-1.5-1.5-1.60.3-0.3
Extinction: sum of active levers before priming1.31.34.30.1-0.2-1.00.8-2.1-0.30.1-1.1-0.4-1.11.11.1-1.4-1.1-1.1-1.1-1.0-1.81.8
Active lever presses in extinction session 63.83.77.70.40.31.4-0.6-0.7-1.6-1.6-2.00.3-2.82.82.8-2.2-2.8-2.8-2.8-2.60.1-0.1
Bone: final force0.30.41.1-0.9-0.8-1.11.0-1.10.50.50.0-1.1-0.40.40.4-0.5-0.2-0.2-0.2-0.2-0.80.7
Bone: final moment0.30.51.2-0.9-0.8-1.01.0-1.10.40.4-0.1-1.1-0.50.50.5-0.6-0.3-0.3-0.3-0.3-0.80.8
Food consumed during 24 hour testing period0.70.81.30.90.90.7-0.70.3-1.0-0.9-1.00.9-1.11.11.1-0.9-0.9-0.9-0.9-1.0-0.50.5
Glucose1.82.88.0-2.6-2.7-2.32.8-2.51.92.30.5-2.3-0.60.60.6-1.1-0.4-0.4-0.4-0.4-1.10.9
Heart weight2.43.46.1-1.1-1.1-0.30.31.11.50.52.2-0.42.4-2.4-2.42.32.42.42.42.51.8-1.8
Delay discount hyperbolic model param1.21.23.00.10.01.10.1-0.1-0.7-0.7-1.10.6-1.51.51.5-1.5-1.6-1.6-1.6-1.70.1-0.1
Intermittent access intake day 1-15 change1.31.33.11.11.01.2-1.00.4-1.8-1.4-1.70.4-1.41.41.4-1.2-1.1-1.1-1.1-1.3-0.30.4
Intermittent access intake escalation1.61.53.01.01.01.3-1.00.4-1.7-1.4-1.70.3-1.61.61.6-1.2-1.3-1.3-1.3-1.3-0.20.3
Intermittent access intake escalation 22.92.96.20.60.60.5-0.4-0.9-1.8-1.1-2.3-0.7-2.52.52.5-2.1-2.1-2.1-2.1-2.1-0.91.0
Intermitt. access day 1 inactive lever presses1.61.84.11.71.81.2-1.70.7-2.0-1.4-1.80.5-1.21.21.2-1.0-1.4-1.4-1.4-1.3-0.20.3
Intermitt. access day 15 inactive lever presses1.31.44.81.21.40.3-0.7-0.7-2.1-1.6-2.2-0.5-0.90.90.9-1.4-0.8-0.8-0.8-0.9-1.31.4
Intermitt. access escalation Index0.10.10.30.20.40.2-0.40.5-0.5-0.2-0.4-0.1-0.20.20.2-0.20.10.10.1-0.2-0.00.0
Intermittent access day 1 total infusions0.50.62.31.51.30.4-0.6-0.7-0.6-0.6-1.10.9-0.30.30.3-0.7-0.4-0.4-0.4-0.2-1.01.0
Intermittent access day 15 total infusions3.43.87.92.22.01.9-1.6-0.2-2.2-2.0-2.81.7-2.22.22.2-2.2-2.0-2.0-2.0-2.0-0.80.9
Intermittent access terminal intake (last 3 days)2.93.26.42.21.91.6-1.6-0.4-2.0-1.8-2.51.4-2.12.12.1-1.8-1.9-1.9-1.9-1.8-0.70.8
Intermittent access total infusions2.02.24.51.91.81.2-1.2-0.6-1.5-1.4-2.11.4-1.51.51.5-1.6-1.5-1.5-1.5-1.5-0.91.0
Intermittent access day 1 locomotion0.80.84.52.11.91.0-1.40.2-1.0-0.9-1.11.00.0-0.0-0.0-0.4-0.0-0.0-0.0-0.0-0.70.8
Intermittent access day 15 total locomotion2.12.25.31.31.20.5-0.6-1.1-1.5-0.8-2.3-0.9-1.71.71.7-2.0-1.6-1.6-1.6-1.6-1.51.5
Intermittent access total locomotion2.83.18.32.12.00.7-1.1-1.1-2.2-1.5-2.90.3-1.71.71.7-2.3-1.6-1.6-1.6-1.7-2.02.1
Intermittent access standard deviation1.92.04.00.60.51.3-0.70.0-1.0-1.0-1.51.8-1.91.91.9-1.5-2.0-2.0-2.0-1.80.1-0.1
Left kidney weight0.71.95.42.32.30.5-2.11.6-1.5-1.8-0.21.01.0-1.0-1.01.51.31.31.31.4-0.30.4
Right kidney weight0.61.75.72.42.30.9-2.11.3-1.9-2.0-0.70.90.6-0.6-0.60.80.70.70.70.7-0.70.8
Cocaine induced anxiety0.30.30.90.00.3-0.10.0-0.6-0.1-0.0-0.90.1-0.60.60.6-1.0-0.7-0.7-0.7-0.6-0.50.5
Post-drug Anxiety1.11.23.6-0.8-0.6-1.31.0-1.9-0.10.5-1.0-1.3-0.80.80.8-1.5-1.1-1.1-1.1-1.0-1.61.5
Baseline Anxiety0.10.10.3-0.2-0.3-0.30.3-0.3-0.10.00.1-0.2-0.40.40.4-0.1-0.4-0.4-0.4-0.5-0.40.4
Tail length0.61.73.71.31.51.2-1.40.3-1.9-1.8-1.80.8-1.41.41.4-1.1-1.3-1.3-1.3-1.0-0.40.5
Length with tail0.10.40.90.50.60.5-0.50.2-0.6-0.7-0.50.6-0.90.90.9-0.3-0.7-0.7-0.7-0.4-0.20.2
Length without tail0.10.20.3-0.3-0.3-0.40.4-0.30.50.40.20.4-0.50.50.5-0.1-0.4-0.4-0.4-0.2-0.60.5
Times rat made contact with spout5.05.811.53.43.43.1-3.32.2-3.4-3.4-2.72.5-1.81.81.8-1.1-1.9-1.9-1.9-1.90.3-0.1
Lifetime Intake0.70.81.81.31.31.1-0.9-0.3-0.8-1.0-1.21.0-0.90.90.9-0.7-0.9-0.9-0.9-0.7-0.20.3
Liver weight, left0.20.31.10.91.00.2-0.50.0-0.9-0.6-0.60.1-0.40.40.4-0.3-0.4-0.4-0.4-0.2-0.80.9
Liver weight, right0.10.10.30.20.20.1-0.20.40.20.20.50.50.4-0.4-0.40.50.50.50.50.40.1-0.1
Locomotor activity1.11.85.52.32.21.1-2.11.4-2.0-2.1-1.21.4-0.90.90.9-0.0-0.6-0.6-0.6-0.4-0.60.7
Locomotor testing distance1.01.73.01.71.51.2-1.51.0-1.3-1.4-1.31.5-1.61.61.6-0.8-1.3-1.3-1.3-1.1-0.30.3
Locomotor testing rearing0.20.31.71.31.00.3-0.90.8-0.5-0.7-0.30.6-0.00.00.00.30.00.00.00.2-0.30.4
Locomotion in novel chamber0.40.51.20.90.80.4-0.5-0.3-1.1-0.8-1.10.1-0.70.70.7-0.8-0.6-0.6-0.6-0.8-0.40.5
Locomotion in novel chamber post-restriction1.01.32.0-1.3-1.4-0.70.90.71.21.01.3-1.21.3-1.3-1.31.01.11.11.11.11.2-1.2
Fecal boli incidents, locomotor time 10.80.81.50.70.8-0.6-0.2-0.9-0.4-0.50.1-0.71.1-1.1-1.10.71.21.21.21.2-1.21.2
Change in fecal boli incidents, locomotor task1.01.03.01.31.40.9-1.71.6-1.7-1.5-0.91.1-0.40.40.40.0-0.4-0.4-0.4-0.40.4-0.3
Time >=10cm from walls, locomotor time 10.90.91.70.70.60.8-0.60.4-1.3-1.2-1.30.2-1.21.21.2-1.1-1.1-1.1-1.1-1.1-0.40.5
Bouts of movement, locomotor time 10.10.10.4-0.0-0.50.00.3-0.10.2-0.1-0.20.1-0.50.50.5-0.5-0.6-0.6-0.6-0.4-0.10.1
Total resting periods, locomotor time 10.10.20.3-0.0-0.4-0.20.3-0.30.0-0.1-0.4-0.0-0.50.50.5-0.6-0.6-0.6-0.6-0.4-0.40.4
Rest time, locomotor task time 11.61.72.8-0.7-0.7-1.70.9-1.11.11.21.2-1.21.7-1.7-1.71.21.61.61.61.6-0.90.9
Distance moved, locomotor task time 11.21.35.40.50.51.9-1.22.3-0.5-1.0-0.31.0-0.60.60.6-0.0-0.6-0.6-0.6-0.72.1-2.0
Vertical activity count, locomotor time 10.50.51.3-0.10.11.0-0.20.8-0.2-0.5-0.60.6-0.80.80.8-1.0-0.8-0.8-0.8-1.10.6-0.6
Time >=10cm from walls, locomotor time 20.40.41.2-0.9-0.9-0.10.40.00.80.40.9-0.60.2-0.2-0.20.60.40.40.40.41.0-1.1
Bouts of movement, locomotor time 21.71.97.1-1.3-1.3-2.41.8-1.71.01.60.1-2.70.2-0.2-0.2-0.60.40.40.40.4-2.02.0
Total resting periods, locomotor time 21.11.25.3-0.7-0.7-1.91.2-1.40.41.1-0.3-2.30.0-0.0-0.0-0.70.10.10.10.1-2.02.0
Rest time, locomotor task time 20.70.83.10.40.5-0.2-0.1-1.0-0.9-0.4-1.2-1.0-0.50.50.5-1.0-0.6-0.6-0.6-0.7-1.71.8
Distance moved, locomotor task time 21.41.67.3-0.5-0.60.8-0.11.81.30.51.60.60.8-0.8-0.81.41.01.01.00.92.7-2.7
Vertical activity count, locomotor time 21.01.12.9-0.8-0.9-0.10.60.91.70.91.50.21.0-1.0-1.00.91.11.11.11.01.4-1.4
Light reinforcement 10.20.40.9-0.4-0.3-0.80.3-0.30.60.50.9-0.40.8-0.8-0.81.00.80.80.80.9-0.40.3
Light reinforcement 22.53.39.0-2.9-2.6-3.02.7-2.52.12.71.5-2.20.7-0.7-0.70.40.60.60.60.8-1.31.2
Bone: marrow area2.86.011.2-3.0-3.1-3.33.1-2.13.33.42.7-2.42.3-2.3-2.31.42.12.12.12.1-0.30.2
Bone: maximum diameter0.71.24.0-1.1-1.1-1.91.7-2.00.81.20.0-1.6-0.20.20.2-0.7-0.2-0.2-0.2-0.2-1.61.6
Bone: maximum force0.20.31.0-1.0-0.9-0.70.9-0.70.60.70.3-0.8-0.20.20.2-0.3-0.1-0.1-0.1-0.2-0.10.1
Bone: maximum moment0.20.30.7-0.9-0.8-0.80.8-0.70.50.60.2-0.8-0.20.20.2-0.3-0.1-0.1-0.1-0.2-0.30.3
Mean time between licks in bursts1.01.44.01.71.62.0-2.01.6-1.4-1.8-0.61.7-0.40.40.40.3-0.3-0.3-0.3-0.41.1-1.0
Mean num. licks in bursts2.12.54.60.91.00.7-0.7-0.3-1.8-1.2-2.1-0.0-2.12.12.1-1.9-2.0-2.0-2.0-2.0-1.01.1
Cd content in liver1.31.44.01.01.22.0-1.61.5-1.1-1.5-0.91.6-0.70.70.7-0.4-1.0-1.0-1.0-1.01.3-1.2
Co content in liver0.10.10.3-0.0-0.1-0.30.10.00.20.20.40.20.5-0.5-0.50.40.50.50.50.5-0.10.1
Cu content in liver0.10.10.30.1-0.00.4-0.00.20.20.2-0.00.5-0.30.30.3-0.2-0.3-0.3-0.3-0.30.5-0.5
Fe content in liver1.01.22.5-0.3-0.41.10.00.2-0.3-0.3-0.70.9-1.61.61.6-1.2-1.5-1.5-1.5-1.51.0-1.0
K content in liver0.70.71.7-0.7-0.9-0.20.70.21.10.81.30.31.0-1.0-1.00.90.90.90.90.90.7-0.8
Mg content in liver0.40.51.3-0.7-0.90.10.60.21.00.61.00.30.5-0.5-0.50.50.40.40.40.41.1-1.2
Mn content in liver1.21.42.6-1.0-1.2-1.61.3-1.01.51.41.3-0.91.3-1.3-1.30.81.21.21.21.2-0.60.5
Na content in liver1.61.74.7-1.9-2.1-1.82.2-2.11.21.90.2-1.8-0.70.70.7-0.9-0.4-0.4-0.4-0.4-1.00.9
Rb content in liver0.50.61.51.11.11.2-1.11.2-0.4-0.70.01.20.6-0.6-0.60.60.30.30.30.30.7-0.7
Se content in liver1.11.33.00.50.31.7-0.91.1-0.6-0.9-0.81.1-1.31.31.3-0.8-1.4-1.4-1.4-1.41.4-1.3
Sr content in liver0.80.82.71.61.51.1-1.51.2-1.2-1.3-0.71.1-0.10.10.10.2-0.1-0.1-0.1-0.10.1-0.0
Zn content in liver0.91.01.70.90.50.7-0.4-0.2-1.0-0.7-1.20.7-1.21.21.2-1.2-1.3-1.3-1.3-1.3-0.60.7
Bone: minimum diameter2.03.89.9-3.1-3.1-3.03.1-2.72.72.91.4-2.60.4-0.4-0.4-0.20.50.50.50.5-0.80.6
Time in familiar zone, hab. session 10.20.21.10.30.1-0.60.2-0.7-0.0-0.0-0.1-0.20.1-0.1-0.1-0.10.20.20.20.1-1.11.1
Time in novel zone, hab. session 11.11.04.8-1.0-0.90.40.20.91.10.81.20.00.7-0.7-0.71.00.70.70.70.72.2-2.2
Total zone transitions, hab. session 10.50.72.01.41.40.4-1.00.3-1.2-1.0-1.00.7-0.60.60.6-0.4-0.5-0.5-0.5-0.2-1.11.1
Total locomotion distance, hab. session 10.50.82.61.51.61.0-1.40.9-1.2-1.2-0.81.1-0.60.60.6-0.1-0.3-0.3-0.3-0.2-0.20.3
Locomotion velocity, hab. session 10.60.82.71.51.71.1-1.41.0-1.2-1.2-0.71.3-0.50.50.5-0.0-0.3-0.3-0.3-0.2-0.20.3
Time in familiar zone, hab. session 21.01.02.3-0.7-0.7-1.50.9-1.10.71.00.7-1.31.1-1.1-1.10.71.21.21.21.0-1.01.0
Time in novel zone, hab. session 20.60.61.80.50.51.3-0.81.2-0.3-0.7-0.11.2-0.50.50.5-0.0-0.5-0.5-0.5-0.41.3-1.3
Total zone transitions, hab. session 20.40.52.31.00.8-0.5-0.4-0.2-0.7-0.4-0.3-0.20.5-0.5-0.50.30.60.60.60.6-1.51.5
Total locomotion distance, hab. session 20.70.93.01.71.70.6-1.41.0-1.1-1.1-0.20.60.6-0.6-0.60.90.90.90.90.8-0.50.6
Locomotion velocity, hab. session 20.60.82.81.71.70.5-1.41.0-1.0-1.0-0.20.80.5-0.5-0.50.80.80.80.80.7-0.60.7
Novel to familiar place preference ratio0.70.72.9-0.0-0.10.8-0.41.30.50.20.91.00.7-0.7-0.70.90.60.60.60.41.7-1.7
Novelty place preference1.11.13.5-0.3-0.40.5-0.11.30.90.51.30.81.0-1.0-1.01.21.01.01.00.81.8-1.9
Time in novel zone, NPP test1.11.23.2-0.5-0.60.30.01.11.10.71.40.51.1-1.1-1.11.31.11.11.10.91.7-1.8
Total zone transitions, NPP test0.30.52.60.40.2-0.80.2-0.9-0.5-0.1-0.7-0.7-0.40.40.4-0.6-0.3-0.3-0.3-0.2-1.61.6
Total locomotion distance, NPP test0.10.20.40.60.60.2-0.50.5-0.3-0.40.10.40.3-0.3-0.30.50.50.50.50.40.00.0
Locomotion velocity, NPP test0.20.20.80.90.80.4-0.70.7-0.5-0.6-0.00.70.2-0.2-0.20.40.40.40.40.3-0.00.1
Intraocular pressure0.60.93.3-0.4-0.40.7-0.20.91.00.31.10.60.9-0.9-0.91.10.90.90.90.81.8-1.8
Delta distance traveled before/after self-admin1.71.83.70.10.1-0.1-0.31.50.90.31.60.81.9-1.9-1.91.91.71.71.71.71.0-1.0
Delta ambulatory time before/after self-admin1.61.73.90.10.2-0.3-0.31.30.80.51.60.72.0-2.0-2.01.81.71.71.71.70.6-0.6
Parametrial fat weight1.63.26.7-1.9-1.8-2.41.9-0.82.42.12.6-0.41.7-1.7-1.71.61.91.91.91.8-0.30.1
Pavlov. Cond. lever latency0.10.10.3-0.10.10.0-0.20.40.20.00.50.40.5-0.5-0.50.60.40.40.40.50.3-0.3
Pavlov. Cond. magazine entry latency0.30.41.01.00.81.0-1.01.0-0.5-0.9-0.10.90.3-0.3-0.30.40.20.20.20.10.7-0.6
Pavlov. Cond. change in total contacts0.10.10.20.40.40.1-0.20.1-0.4-0.4-0.3-0.10.0-0.0-0.0-0.10.10.10.1-0.0-0.40.5
Pavlov. Cond. index score0.10.10.30.50.40.5-0.40.3-0.4-0.5-0.30.3-0.10.10.1-0.1-0.2-0.2-0.2-0.30.00.0
Pavlov. Cond. latency score0.10.10.40.60.50.6-0.50.4-0.4-0.5-0.30.4-0.10.10.1-0.1-0.1-0.1-0.1-0.20.00.0
Pavlov. Cond. lever contacts0.50.61.20.50.40.1-0.1-0.5-0.8-0.3-1.1-0.3-0.90.90.9-1.1-0.9-0.9-0.9-1.0-0.90.9
Pavlov. Cond. magazine entry number0.10.20.5-0.5-0.3-0.70.5-0.70.20.5-0.1-0.6-0.30.30.3-0.3-0.2-0.2-0.2-0.1-0.70.6
Pavlov. Cond. intertrial magazine entries2.02.45.4-2.1-2.3-1.32.0-2.10.81.2-0.5-2.3-1.41.41.4-1.8-1.5-1.5-1.5-1.4-0.30.3
Pavlov. Cond. lever-magazine prob. diff.0.10.10.20.50.30.4-0.30.2-0.4-0.5-0.30.2-0.10.10.1-0.1-0.1-0.1-0.1-0.2-0.00.1
Pavlov. Cond. response bias0.20.20.60.80.60.6-0.60.3-0.7-0.7-0.70.2-0.40.40.4-0.4-0.4-0.4-0.4-0.5-0.20.2
Pavlov. Cond. lever latency1.11.55.31.21.31.9-1.82.3-0.7-1.20.11.70.3-0.3-0.30.90.30.30.30.31.9-1.9
Pavlov. Cond. magazine entry latency0.40.52.00.30.2-0.50.1-0.8-0.7-0.3-0.9-0.4-0.70.70.7-0.8-0.5-0.5-0.5-0.5-1.41.4
Pavlov. Cond. change in total contacts0.70.92.8-0.7-1.0-1.71.4-1.60.81.30.4-1.20.4-0.4-0.4-0.10.40.40.40.4-1.51.4
Pavlov. Cond. index score0.81.13.1-0.2-0.3-0.90.8-1.6-0.40.2-1.0-0.9-1.01.01.0-1.3-1.0-1.0-1.0-0.9-1.71.7
Pavlov. Cond. latency score0.60.72.50.20.1-0.70.4-1.1-0.5-0.0-0.9-0.6-0.70.70.7-1.0-0.7-0.7-0.7-0.7-1.61.6
Pavlov. Cond. lever contacts0.60.82.8-0.7-0.9-1.51.3-1.70.50.9-0.0-1.4-0.00.00.0-0.5-0.1-0.1-0.1-0.0-1.61.5
Pavlov. Cond. magazine entry number0.20.20.80.30.30.9-0.50.8-0.2-0.4-0.10.5-0.20.20.20.0-0.3-0.3-0.3-0.30.9-0.9
Pavlov. Cond. intertrial magazine entries0.20.20.4-0.5-0.5-0.20.5-0.60.20.1-0.2-0.4-0.60.60.6-0.6-0.6-0.6-0.6-0.6-0.10.0
Pavlov. Cond. lever-magazine prob. diff.0.81.13.5-0.1-0.2-0.90.7-1.5-0.40.1-1.0-0.8-1.01.01.0-1.3-0.9-0.9-0.9-0.9-1.91.9
Pavlov. Cond. response bias0.60.82.8-0.7-0.7-1.41.2-1.70.30.8-0.2-1.2-0.30.30.3-0.7-0.2-0.2-0.2-0.2-1.71.6
Time in closed arm before self-admin0.60.72.7-0.9-0.7-1.50.7-0.80.50.90.6-1.60.7-0.7-0.70.50.70.70.70.6-0.40.4
Time in closed arm after self-admin4.95.010.3-0.6-0.7-1.70.50.91.71.12.8-0.63.0-3.0-3.03.03.23.23.23.10.8-0.8
Time in open arm before self-admin0.20.21.30.60.50.7-0.30.4-0.6-0.5-0.11.2-0.20.20.20.1-0.1-0.1-0.10.0-0.20.2
Time in open arm after self-admin1.01.12.5-0.2-0.30.10.6-1.3-0.10.5-1.10.2-1.21.21.2-1.6-1.4-1.4-1.4-1.4-0.90.9
Bone: periosteal estimation0.91.95.1-1.8-1.8-2.22.1-1.81.81.91.1-1.90.8-0.8-0.80.20.70.70.70.7-0.80.7
Bone: periosteal perimeter0.71.23.8-0.9-0.9-1.81.5-2.00.50.9-0.2-1.4-0.40.40.4-0.9-0.4-0.4-0.4-0.4-1.81.7
Bone: post-yield work0.50.71.5-0.9-1.2-0.81.2-1.10.60.9-0.1-0.6-0.70.70.7-1.0-0.7-0.7-0.7-0.8-0.60.5
Progressive ratio test 1 active lever presses0.30.31.91.41.01.0-0.90.5-0.6-0.8-0.30.20.1-0.1-0.10.40.10.10.10.4-0.10.2
Progressive ratio test 1 breakpoint0.40.52.31.51.11.1-1.10.8-0.6-0.8-0.10.50.2-0.2-0.20.60.20.20.20.50.2-0.1
Progressive ratio test 1 inactive lever presses0.70.82.01.01.11.4-1.20.5-1.4-1.2-1.2-0.0-0.80.80.8-0.6-0.8-0.8-0.8-0.80.2-0.2
Progressive ratio test 2 active lever presses2.32.54.31.61.61.6-1.2-0.4-1.7-1.6-2.10.5-1.91.91.9-1.5-2.0-2.0-2.0-1.7-0.50.6
Progressive ratio test 2 breakpoint2.32.64.61.41.41.6-1.2-0.3-1.7-1.6-2.10.5-2.02.02.0-1.6-2.1-2.1-2.1-1.8-0.40.5
Progressive ratio test 2 inactive lever presses4.35.012.41.82.11.1-1.2-1.2-2.9-2.3-3.5-1.0-2.42.42.4-2.7-2.5-2.5-2.5-2.3-1.82.0
Incentive Sensitization - Responses2.22.34.60.40.60.3-0.0-1.4-1.1-0.7-1.9-0.8-1.91.91.9-2.0-2.1-2.1-2.1-1.9-1.01.0
Incentive Sensitization - Breakpoint2.52.65.20.40.60.3-0.1-1.5-1.2-0.8-2.1-0.8-2.12.12.1-2.1-2.3-2.3-2.3-2.1-1.01.1
Sum of active levers in priming session hrs 5-61.41.32.70.2-0.10.30.2-1.1-0.8-0.6-1.30.3-1.61.61.6-1.6-1.6-1.6-1.6-1.5-0.50.5
Progressive ratio0.10.10.3-0.4-0.3-0.10.10.40.20.4-0.10.2-0.30.30.3-0.4-0.5-0.5-0.5-0.50.1-0.1
Food seeking constrained by brief footshock0.81.02.61.11.51.5-1.41.6-1.0-1.1-0.51.6-0.60.60.6-0.1-0.5-0.5-0.5-0.50.6-0.5
Seeking ratio, punishment vs. effort0.50.61.61.11.21.3-1.21.1-0.8-1.1-0.10.8-0.10.10.10.50.20.20.20.30.7-0.7
Retroperitoneal fat weight1.03.38.3-2.9-2.7-2.42.7-1.62.72.72.1-1.71.1-1.1-1.10.61.31.31.31.1-0.30.1
Reaction time number correct0.30.40.8-0.30.3-0.40.3-0.9-0.0-0.1-0.6-0.9-0.60.60.6-0.8-0.6-0.6-0.6-0.6-0.80.8
Reaction time mean minus median0.70.92.40.50.60.5-0.8-0.2-1.5-1.2-1.50.2-1.21.21.2-1.0-1.1-1.1-1.1-1.0-0.40.4
Reaction time mean minus median AUC1.11.43.2-0.10.1-0.2-0.1-1.2-1.4-0.8-1.8-0.6-1.41.41.4-1.6-1.4-1.4-1.4-1.3-1.11.2
Reaction time num false alarms1.41.94.91.71.92.0-2.12.2-1.4-1.8-0.52.2-0.90.90.90.3-0.7-0.7-0.7-0.61.1-1.1
Reaction time num false alarms AUC1.31.86.31.82.01.8-2.12.2-1.2-1.7-0.22.5-0.50.50.50.7-0.4-0.4-0.4-0.31.0-0.9
Reaction time trials correct on left0.30.40.8-0.30.3-0.40.3-0.9-0.0-0.1-0.6-0.9-0.60.60.6-0.8-0.6-0.6-0.6-0.6-0.80.8
Reaction time trials on left0.30.40.9-0.30.3-0.50.3-1.0-0.0-0.1-0.6-0.9-0.60.60.6-0.8-0.6-0.6-0.6-0.6-0.80.8
Reaction time mean0.30.42.0-0.6-0.50.5-0.20.60.2-0.10.60.70.5-0.5-0.50.60.40.40.40.51.4-1.4
Reaction time mean AUC0.10.20.9-0.4-0.30.5-0.20.3-0.1-0.4-0.00.7-0.10.10.10.0-0.1-0.1-0.1-0.11.0-1.0
Median of all reaction times1.01.33.4-0.9-0.80.30.10.81.00.41.40.71.3-1.3-1.31.31.21.21.21.21.8-1.9
Reaction time omissions0.10.10.6-0.8-0.5-0.60.1-0.3-0.10.10.0-0.70.1-0.1-0.10.20.10.10.10.10.1-0.1
Reaction time false alarm rate1.41.97.41.81.71.9-2.12.5-1.1-1.50.12.7-0.30.30.31.0-0.1-0.1-0.10.01.4-1.3
Reaction time premature initiation rate1.11.42.2-0.9-1.2-1.41.2-1.01.11.41.1-1.21.5-1.5-1.50.81.31.31.31.3-0.50.4
Reaction time premature initiations0.60.92.7-0.9-0.9-1.51.2-1.60.71.10.4-1.70.7-0.7-0.7-0.10.50.50.50.5-1.11.0
Std. dev. reaction times0.50.71.60.30.50.8-1.00.2-1.3-1.2-1.00.9-0.90.90.9-0.6-0.9-0.9-0.9-0.80.4-0.3
Reaction time trials completed0.30.40.9-0.30.3-0.50.3-1.0-0.0-0.1-0.6-0.9-0.60.60.6-0.8-0.6-0.6-0.6-0.6-0.80.8
Reaction time trials AUC0.30.41.1-0.50.0-0.60.6-1.10.30.2-0.4-0.9-0.60.60.6-0.8-0.6-0.6-0.6-0.6-0.80.7
Run reversals in cocaine runway, females0.30.31.30.90.80.2-0.90.7-1.0-1.2-0.6-0.5-0.10.10.10.1-0.0-0.0-0.0-0.0-0.20.2
Run reversals in cocaine runway, males1.00.92.4-0.10.2-0.80.3-1.0-0.9-0.3-1.1-1.5-0.90.90.9-1.1-0.8-0.8-0.8-0.9-1.51.6
Latency to leave start box in cocaine runway0.50.51.1-0.3-0.4-0.1-0.10.70.30.20.80.01.1-1.1-1.10.90.90.90.90.70.6-0.6
Latency to leave start box in cocaine runway, F1.01.13.1-0.2-0.10.4-0.71.80.30.01.20.81.2-1.2-1.21.61.11.11.11.01.6-1.6
Latency to leave start box in cocaine runway, M0.50.51.8-0.6-0.8-0.80.9-1.30.50.60.1-1.00.5-0.5-0.5-0.40.40.40.40.1-1.00.9
Std. dev. time between licks in bursts1.21.53.00.80.90.7-0.7-0.2-1.5-1.2-1.7-0.1-1.61.61.6-1.4-1.4-1.4-1.4-1.5-0.70.7
Total sessions with >9 infusions0.70.82.21.10.91.3-1.21.5-0.3-0.80.40.60.6-0.6-0.61.10.50.50.50.71.1-1.1
Short access day 1 total inactive lever presses1.61.83.71.71.41.6-1.60.6-1.9-1.5-1.71.4-1.31.31.3-1.0-1.3-1.3-1.3-1.20.3-0.2
Short access day 10 total inactive lever presses0.60.61.2-0.7-0.70.20.1-0.2-0.00.4-0.4-0.6-1.11.11.1-0.6-1.1-1.1-1.1-1.10.9-0.9
Short access day 1 total infusions0.40.41.70.40.41.3-0.71.0-0.1-0.70.30.5-0.00.00.00.70.10.10.10.21.2-1.2
Short access day 10 total infusions0.70.82.20.50.31.0-0.60.80.70.10.91.20.8-0.8-0.81.10.80.80.80.91.5-1.5
Short access total infusions0.40.41.20.40.40.7-0.50.40.4-0.20.80.90.6-0.6-0.61.10.60.60.60.80.9-0.9
Short access day 1 locomotion1.01.13.01.40.71.6-1.61.7-0.7-1.30.20.60.4-0.4-0.41.00.30.30.30.31.7-1.6
Short access day 10 total locomotion0.10.20.50.70.5-0.1-0.30.1-0.10.10.00.00.5-0.5-0.50.40.60.60.60.60.00.0
Short access total locomotion0.30.31.00.70.20.2-0.50.30.1-0.10.50.10.7-0.7-0.71.00.70.70.70.90.7-0.6
One hour access (0.3 mA shock)1.51.84.11.41.30.4-0.5-1.2-1.5-1.0-2.00.2-1.51.51.5-1.5-1.4-1.4-1.4-1.3-1.41.5
Compulsive drug intake1.31.35.2-1.0-0.9-2.31.4-1.30.61.20.3-2.30.5-0.5-0.50.10.50.50.50.5-1.51.5
One hour access (shock baseline)2.52.95.71.51.51.6-1.1-0.6-1.8-1.6-2.41.2-2.02.02.0-2.0-2.1-2.1-2.1-2.0-0.60.7
Social response proportion0.40.51.51.21.20.7-1.01.0-0.9-1.1-0.41.1-0.10.10.10.2-0.2-0.2-0.2-0.3-0.10.1
Social responses0.30.41.91.41.30.4-0.90.8-0.5-0.7-0.11.10.2-0.2-0.20.40.20.20.20.1-0.40.4
Social time0.10.10.50.2-0.1-0.50.3-0.60.20.3-0.1-0.20.2-0.2-0.2-0.10.20.20.20.3-0.70.7
Soleus weight0.61.74.8-1.6-1.6-2.22.0-1.91.61.70.9-1.70.6-0.6-0.6-0.10.60.60.60.5-1.31.2
Bone: stiffness0.00.10.10.10.0-0.10.0-0.1-0.2-0.2-0.20.2-0.30.30.3-0.3-0.2-0.2-0.2-0.3-0.30.3
Tibialis anterior weight3.511.931.7-5.6-5.6-4.15.1-3.15.35.03.8-3.91.9-1.9-1.91.01.91.91.91.90.7-1.0
Time to tail flick, vehicle, before self-admin3.03.18.12.11.92.7-2.42.3-1.5-2.4-0.82.8-1.31.31.30.0-0.9-0.9-0.9-0.91.9-1.8
Time to tail flick, vehicle, after self-admin1.41.55.9-1.4-1.4-1.71.4-1.50.81.11.0-2.40.9-0.9-0.90.71.11.11.11.1-0.30.3
Time to tail flick, test, before self-admin0.80.71.70.50.70.3-1.01.1-0.4-0.70.51.00.9-0.9-0.91.31.01.01.00.90.8-0.7
Time to tail flick, test, after self-admin1.01.12.40.60.5-0.4-0.60.9-0.7-0.20.6-0.31.5-1.5-1.51.41.41.41.41.5-0.20.3
Delta time to tail flick, vehicle, before/after SA3.23.210.4-2.1-2.0-2.72.4-2.61.42.10.9-3.21.1-1.1-1.10.31.11.11.11.1-1.51.5
Delta time to tail flick, test, before/after SA0.10.10.50.1-0.0-0.20.2-0.2-0.10.3-0.1-0.70.4-0.4-0.4-0.10.20.20.20.3-0.50.5
Tibia length0.00.00.20.0-0.1-0.0-0.10.1-0.2-0.20.0-0.4-0.00.00.00.30.20.20.20.30.1-0.0
Ambulatory time before self-admin0.40.42.1-0.8-0.9-0.90.9-1.40.10.2-0.3-1.2-0.20.20.2-0.6-0.2-0.2-0.20.0-0.80.8
Ambulatory time after self-admin0.91.01.9-0.7-0.8-0.70.6-0.01.20.71.2-0.21.3-1.3-1.31.01.21.21.21.40.3-0.4
Bone: tissue strength0.20.20.60.70.60.6-0.70.6-0.8-0.8-0.40.3-0.10.10.10.0-0.1-0.1-0.1-0.20.2-0.1
Total heroin consumption1.92.35.72.11.90.3-0.9-0.5-2.2-1.6-2.30.3-1.11.11.1-1.5-1.1-1.1-1.1-1.0-2.32.4
Bone: trabecular number0.20.40.8-0.1-0.00.1-0.20.60.30.10.7-0.10.7-0.7-0.70.90.80.80.80.80.6-0.6
Bone: trabecular spacing0.91.24.62.22.01.2-1.81.1-1.7-1.7-1.10.9-0.10.10.10.1-0.1-0.1-0.1-0.1-0.20.3
Bone: trabecular thickness0.20.30.8-0.9-0.9-0.40.8-0.20.90.80.8-0.20.2-0.2-0.20.20.30.30.30.30.4-0.5
Bone: trabecular tissue density0.40.62.01.31.40.6-1.20.8-1.1-1.1-0.41.00.4-0.4-0.40.40.30.30.30.3-0.30.4
Water consumed over 24 hours0.30.40.90.80.80.2-0.5-0.1-0.7-0.5-0.80.5-0.40.40.4-0.6-0.5-0.5-0.5-0.6-0.91.0
Number of responses in last shaping day0.70.81.91.00.61.1-1.41.3-0.4-0.60.50.50.6-0.6-0.61.30.60.60.60.51.2-1.2