LOC102550985

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	isoform ratio	XR_005499413.1	0.12	0.07	1.3e-09	0.04	0.06	0.05	0.05	8.2e-06	7.9e-07	3.0e-06	1.6e-06
2	Adipose	isoform ratio	XR_005499409.1	0.05	0.03	6.5e-05	0.01	0.02	0.01	0.01	2.8e-02	4.2e-03	1.7e-02	1.4e-02
3	Adipose	alternative polyA	XR_005499413.1	0.1	0.05	9.0e-11	0.05	0.06	0.06	0.06	2.2e-06	2.4e-07	5.5e-07	4.4e-07
4	Adipose	alternative polyA	XR_001835949.2	0.1	0.05	1.0e-10	0.05	0.06	0.06	0.06	7.5e-06	2.4e-07	4.8e-07	4.3e-07
5	Adipose	mRNA stability	LOC102550985	0.3	0.11	0.0e+00	0.13	0.14	0.15	0.15	5.1e-14	6.1e-15	1.9e-16	9.6e-17
6	Adipose	isoform ratio	XR_005499410.1	0.04	0.02	3.9e-04	0	0.01	0.01	0	1.4e-01	2.2e-02	2.5e-02	9.8e-02
7	Brain	gene expression	LOC102550985	0.07	0.05	2.1e-03	0.01	0.03	0.02	0.02	1.3e-02	1.1e-03	4.8e-03	5.5e-03
8	Brain	mRNA stability	LOC102550985	0.09	0.07	4.2e-03	0.02	0.01	0.01	0.02	2.9e-03	4.3e-02	8.5e-02	1.1e-02
9	Adipose	gene expression	LOC102550985	0.09	0.05	1.4e-07	0.05	0.07	0.06	0.07	5.5e-06	8.0e-08	1.5e-07	7.1e-08

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6	7	8	9
Bone: apparent density	0.7	1.2	1.5	1.2	-1.1	1.2	-1.2	-1.0	1.2	1.2	-0.8	0.9
Area under the delay curve	0.3	0.3	0.8	-0.6	0.6	-0.5	0.5	0.5	-0.2	0.5	-0.9	0.6
BMI with tail	1.8	5.9	10.4	3.2	-3.1	3.0	-2.9	-3.0	2.4	0.9	0.6	0.2
BMI without tail	5.7	11.8	19.5	4.4	-4.3	4.1	-4.1	-4.3	3.5	1.7	0.4	0.5
Body weight	1.8	7.5	11.1	3.3	-3.3	3.3	-3.3	-3.2	3.0	1.9	-0.7	1.0
Weight adjusted by age	1.0	1.1	4.1	0.6	-0.6	0.3	-0.3	-0.7	-0.2	-1.3	2.0	-1.7
Bone surface	1.1	1.9	2.6	1.5	-1.6	1.6	-1.6	-1.6	1.6	1.0	-0.4	0.7
Bone volume	1.6	2.7	3.5	1.8	-1.8	1.9	-1.9	-1.7	1.9	1.5	-0.8	1.1
Breakpoint value in progressive ratio session	2.0	2.2	3.2	-1.6	1.6	-1.7	1.7	1.2	-1.8	-1.1	0.8	-1.4
Number of licking bursts	3.4	4.0	7.3	-2.5	2.4	-2.3	2.3	2.7	-2.0	-1.3	0.2	-0.4
Context. condit. distance diff. score	0.5	0.6	0.9	-0.7	0.6	-0.7	0.7	0.3	-0.9	-0.9	0.8	-1.0
Locomotion velocity, session 1	0.3	0.3	0.8	0.2	-0.2	0.3	-0.3	-0.1	0.6	0.9	-0.8	0.9
Locomotion distance, session 1	0.5	0.7	1.2	1.1	-1.0	1.0	-1.0	-1.1	0.8	0.6	-0.1	0.2
Locomotion velocity, session 2	0.2	0.2	0.7	-0.2	0.2	-0.1	0.1	0.4	0.2	0.7	-0.9	0.8
Locomotion distance, session 2	1.9	2.6	3.4	1.8	-1.7	1.8	-1.8	-1.5	1.8	1.6	-0.9	1.2
Locomotion velocity, session 3	0.4	0.5	0.6	0.8	-0.8	0.8	-0.8	-0.8	0.8	0.6	-0.2	0.3
Locomotion distance, session 3	0.6	0.7	1.2	0.9	-1.1	1.0	-1.0	-1.1	1.0	0.3	0.2	0.3
Stereotopy head waving bouts, day 3	0.7	0.8	1.1	-1.0	1.0	-1.1	1.1	0.9	-1.1	-0.6	0.2	-0.5
Stereotopy head waving duration, day 3	0.5	0.6	0.9	-0.8	0.9	-0.9	0.9	0.8	-1.0	-0.5	0.2	-0.5
Locomotion velocity, session 7	2.4	2.6	4.9	1.8	-2.0	1.9	-1.9	-2.2	1.8	0.6	0.3	0.2
Locomotion distance, session 7	0.2	0.3	0.5	0.4	-0.6	0.6	-0.6	-0.7	0.7	-0.1	0.3	0.3
Stereotopy head waving bouts, day 7	0.1	0.2	0.3	0.4	-0.4	0.4	-0.4	-0.5	0.4	0.6	-0.4	0.1
Stereotopy head waving duration, day 7	1.2	1.5	2.4	1.5	-1.5	1.4	-1.4	-1.6	1.2	0.7	0.0	-0.1
Locomotion velocity, session 8	0.1	0.1	0.2	0.1	-0.1	0.2	-0.2	-0.2	0.3	0.5	-0.5	0.4
Locomotion distance, session 8	0.2	0.3	0.5	0.7	-0.6	0.6	-0.6	-0.7	0.5	0.3	0.1	0.0
Degree of sensitization distance	0.7	0.7	1.3	-0.9	1.1	-1.0	1.0	1.1	-0.9	-0.1	-0.5	0.2
Degree of sensitization stereotypy	1.5	1.6	2.2	1.5	-1.5	1.5	-1.5	-1.5	1.4	1.1	-0.5	0.5
Conditioned locomotion	0.3	0.4	1.4	-0.2	-0.1	-0.1	0.1	-0.5	-0.1	-0.9	1.2	-0.9
Cocaine response after cond. corrected	0.1	0.2	0.3	-0.5	0.5	-0.5	0.5	0.5	-0.4	-0.2	0.0	0.1
Cocaine response after cond. not corrected	0.1	0.1	0.2	0.3	-0.4	0.4	-0.4	-0.3	0.4	0.2	-0.0	0.3
Cocaine response before conditioning	2.4	2.9	4.2	1.9	-2.1	2.0	-2.0	-2.0	2.0	1.1	-0.4	0.9
Saline control response	0.3	0.3	0.6	-0.6	0.6	-0.7	0.7	0.5	-0.7	-0.5	0.3	-0.5
Bone: connectivity density	0.4	0.7	1.1	1.0	-1.0	1.0	-1.0	-1.1	0.8	0.4	0.2	0.0
Bone: cortical apparent density	0.5	0.7	1.3	-1.1	1.1	-1.0	1.0	1.1	-0.8	-0.3	-0.2	0.1
Bone: cortical area	3.2	4.9	6.3	2.5	-2.4	2.5	-2.5	-2.1	2.5	2.1	-1.3	1.7
Bone: cortical porosity	0.7	0.7	1.7	1.0	-1.1	0.9	-0.9	-1.3	0.7	0.0	0.6	-0.5
Bone: cortical porosity	0.4	0.4	1.0	0.5	-0.6	0.4	-0.4	-0.9	0.1	-0.5	1.0	-1.0
Bone: cortical thickness	1.9	3.1	5.1	1.5	-1.3	1.6	-1.6	-0.9	1.8	2.3	-2.1	2.2
Bone: cortical thickness	1.6	1.8	6.3	0.1	0.0	0.3	-0.3	0.6	0.8	2.0	-2.5	2.2
Bone: cortical tissue density	0.6	0.7	1.3	-1.1	1.1	-1.0	1.0	1.1	-0.8	-0.3	-0.2	0.1
Condit. Reinf. active minus inactive responses	0.3	0.3	0.6	-0.5	0.5	-0.5	0.5	0.3	-0.7	-0.7	0.8	-0.7
Condit. Reinf. active-inactive response ratio	0.4	0.4	1.5	-0.1	0.0	-0.2	0.2	-0.2	-0.4	-0.9	1.2	-1.0
Condit. Reinf. active responses	0.2	0.3	0.4	-0.5	0.5	-0.6	0.6	0.6	-0.6	-0.4	0.3	-0.4
Condit. Reinf. inactive responses	0.1	0.1	0.4	-0.2	0.4	-0.3	0.3	0.6	-0.3	0.1	-0.5	0.2
Incentive salience index mean	0.2	0.2	0.9	0.3	-0.3	0.2	-0.2	-0.4	0.1	-0.5	1.0	-0.5
Condit. Reinf. lever presses	0.3	0.5	1.9	0.2	-0.4	0.2	-0.2	-0.5	0.0	-0.9	1.4	-0.9
Condit. Reinf. active minus inactive responses	0.1	0.2	0.6	0.3	-0.1	-0.0	0.0	-0.2	-0.4	-0.4	0.6	-0.8
Condit. Reinf. active-inactive response ratio	0.5	0.6	1.1	-0.5	0.7	-0.7	0.7	0.7	-1.0	-0.7	0.6	-1.0
Condit. Reinf. active responses	0.1	0.2	0.4	0.5	-0.4	0.3	-0.3	-0.5	-0.0	-0.2	0.6	-0.6
Condit. Reinf. inactive responses	1.3	1.6	2.8	1.4	-1.5	1.5	-1.5	-1.7	1.4	0.6	0.0	0.4
Condit. Reinf. lever presses	0.6	0.9	1.8	1.2	-1.2	1.1	-1.1	-1.3	0.7	0.2	0.4	-0.4
Condit. Reinf. lever reinforcers received	0.2	0.3	1.0	0.2	-0.1	-0.1	0.1	-0.3	-0.4	-0.6	0.9	-1.0
Conditioned reinforcement - actives	1.3	1.3	5.7	0.2	0.0	0.3	-0.3	0.1	0.6	1.8	-2.4	1.7
Conditioned reinforcement - inactives	0.8	0.9	3.1	-0.7	0.9	-0.6	0.6	1.0	-0.3	0.9	-1.8	1.2
Conditioned locomotion	0.1	0.1	0.3	-0.2	0.2	-0.1	0.1	0.2	-0.0	0.3	-0.5	0.3
Patch foraging indifference point 0 sec	0.1	0.1	0.4	0.3	-0.1	0.1	-0.1	-0.0	0.0	0.7	-0.6	-0.0
Patch foraging indifference point AUC	0.6	0.7	1.5	0.6	-0.4	0.6	-0.6	-0.1	0.7	1.1	-1.2	1.2
Delay disc. indifference point, 0s delay	1.5	1.6	3.5	0.9	-0.9	1.1	-1.1	-0.6	1.4	1.6	-1.5	1.9
Delay disc. indifference point, 16s delay	4.8	4.9	7.7	-2.8	2.8	-2.7	2.7	2.5	-2.4	-1.1	-0.1	-0.7
Delay disc. indifference point, 2s delay	4.1	4.5	6.0	2.3	-2.3	2.4	-2.4	-1.9	2.5	2.0	-1.4	1.9
Delay disc. indifference point, 24s delay	2.6	2.6	4.2	-2.1	2.0	-1.9	1.9	1.7	-1.7	-1.0	0.2	-0.7
Delay disc. indifference point, 4s delay	1.0	1.1	4.1	-0.2	0.3	0.0	-0.0	0.5	0.4	1.4	-2.0	1.7
Delay disc. indifference point, 8s delay	0.3	0.4	1.1	0.0	-0.1	0.2	-0.2	-0.1	0.5	0.9	-1.1	1.0
Indifference point function ln k	0.3	0.4	0.5	0.7	-0.7	0.7	-0.7	-0.7	0.7	0.6	-0.3	0.2
Indifference point function log k	0.3	0.4	0.5	0.7	-0.7	0.7	-0.7	-0.7	0.7	0.6	-0.3	0.2
Patch foraging total patch changes 0 sec	0.1	0.1	0.4	0.3	-0.1	0.1	-0.1	-0.1	-0.0	0.6	-0.5	-0.2
Patch foraging total patch changes 12 sec	0.1	0.1	0.1	0.4	-0.3	0.3	-0.3	-0.3	0.1	-0.1	0.3	-0.2
Patch foraging total patch changes 18 sec	0.2	0.3	0.6	-0.4	0.5	-0.4	0.4	0.8	-0.3	0.4	-0.8	0.5
Patch foraging total patch changes 24 sec	0.2	0.2	0.7	0.4	-0.3	0.3	-0.3	-0.2	0.3	0.8	-0.8	0.5
Patch foraging total patch changes 6 sec	1.2	1.8	3.7	-1.2	1.6	-1.3	1.3	1.9	-1.2	0.7	-1.6	0.4
Patch foraging time to switch 0 sec	1.5	2.4	6.1	-1.2	0.8	-1.1	1.1	0.3	-1.2	-2.4	2.5	-1.9
Patch foraging water rate 0 sec	0.1	0.2	0.3	0.5	-0.5	0.5	-0.5	-0.4	0.5	0.5	-0.4	0.2
Patch foraging water rate 12 sec	0.5	0.8	2.0	0.7	-0.5	0.7	-0.7	-0.5	0.7	1.4	-1.4	0.9
Patch foraging water rate 18 sec	0.1	0.1	0.2	0.3	-0.2	0.2	-0.2	-0.4	0.1	0.4	-0.3	-0.2
Patch foraging water rate 24 sec	0.7	1.0	2.5	0.6	-0.5	0.7	-0.7	-0.3	0.9	1.4	-1.6	1.4
Patch foraging water rate 6 sec	0.5	0.8	2.7	-0.3	0.5	-0.3	0.3	1.0	-0.0	1.2	-1.7	1.1
Seeking ratio, delayed vs. immediate footshock	0.0	0.0	0.0	-0.1	0.1	-0.1	0.1	0.0	-0.1	0.0	-0.1	0.1
Distance traveled before self-admin	0.6	0.6	2.0	0.1	-0.0	0.2	-0.2	-0.1	0.5	1.2	-1.4	1.3
Distance traveled after self-admin	2.4	2.6	3.6	1.5	-1.5	1.6	-1.7	-1.2	1.9	1.7	-1.5	1.9
Extensor digitorum longus weight	4.7	18.6	25.8	4.8	-5.0	5.0	-5.0	-4.6	5.1	3.3	-1.4	2.8
Bone: elastic displacement	0.7	0.8	1.6	-1.0	1.2	-1.0	1.0	1.3	-0.9	0.2	-0.7	0.3
Bone: elastic work	0.3	0.4	0.8	0.5	-0.4	0.5	-0.6	-0.3	0.6	0.9	-0.8	0.8
Bone: endosteal estimation	1.6	3.4	5.6	2.3	-2.3	2.2	-2.2	-2.4	2.0	0.6	0.5	0.1
Bone: endosteal perimeter	1.2	2.4	4.0	1.8	-2.0	1.9	-1.9	-2.0	1.7	0.4	0.5	0.2
Epididymis fat weight	0.3	0.7	1.4	1.2	-1.0	1.0	-1.0	-0.9	0.7	0.4	0.2	-0.2
Delta time in closed arm before/after self-admin	0.4	0.4	1.7	-0.1	-0.2	-0.0	0.1	-0.3	-0.2	-1.1	1.3	-0.9
Delta time in open arm before/after self-admin	1.4	1.4	2.0	1.3	-1.1	1.2	-1.2	-0.7	1.2	1.4	-1.2	1.2
Diff in mean of infusions in LGA sessions	1.0	1.1	1.9	-1.1	1.4	-1.3	1.3	1.3	-1.4	-0.3	-0.0	-0.7
Delay discount exponential model param	0.2	0.2	0.5	0.6	-0.6	0.5	-0.5	-0.5	0.2	-0.3	0.7	-0.5
Extinction: sum of active levers before priming	0.3	0.3	0.4	-0.6	0.6	-0.6	0.6	0.6	-0.5	-0.4	0.2	-0.2
Active lever presses in extinction session 6	0.3	0.3	0.6	-0.5	0.6	-0.6	0.6	0.5	-0.7	-0.3	0.4	-0.8
Bone: final force	5.2	8.4	11.8	3.4	-3.2	3.4	-3.4	-2.7	3.3	2.6	-1.4	1.9
Bone: final moment	4.1	6.7	9.5	3.1	-2.9	3.0	-3.0	-2.4	2.9	2.4	-1.3	1.7
Food consumed during 24 hour testing period	1.8	2.2	2.8	1.7	-1.5	1.6	-1.7	-1.1	1.7	1.5	-1.0	1.3
Glucose	0.3	0.4	1.4	-0.3	0.5	-0.3	0.3	0.8	-0.2	0.9	-1.2	0.6
Heart weight	0.4	0.6	1.4	-0.5	0.8	-0.6	0.6	1.1	-0.5	0.6	-1.2	0.8
Delay discount hyperbolic model param	0.2	0.2	0.9	0.3	-0.3	0.2	-0.2	-0.3	-0.1	-0.6	0.9	-0.8
Intermittent access intake day 1-15 change	0.3	0.3	0.9	-0.6	0.6	-0.4	0.4	0.9	-0.2	0.2	-0.6	0.8
Intermittent access intake escalation	0.3	0.3	0.8	-0.5	0.5	-0.4	0.4	0.9	-0.1	0.3	-0.8	0.9
Intermittent access intake escalation 2	0.4	0.4	1.0	-0.7	0.7	-0.6	0.6	1.0	-0.3	0.0	-0.6	0.8
Intermitt. access day 1 inactive lever presses	0.5	0.5	1.9	-0.5	0.5	-0.4	0.4	0.6	-0.1	0.6	-1.4	1.1
Intermitt. access day 15 inactive lever presses	0.9	1.0	1.4	1.0	-1.0	1.1	-1.1	-0.9	1.2	1.0	-0.7	1.0
Intermitt. access escalation Index	0.6	0.5	1.1	1.0	-0.9	0.9	-0.9	-0.6	0.7	0.4	0.2	0.1
Intermittent access day 1 total infusions	0.4	0.5	1.0	0.9	-0.8	0.8	-0.8	-1.0	0.6	0.6	-0.2	-0.1
Intermittent access day 15 total infusions	0.1	0.1	0.4	0.2	-0.1	0.2	-0.2	0.0	0.2	0.6	-0.7	0.4
Intermittent access terminal intake (last 3 days)	0.1	0.1	0.4	0.2	-0.0	0.1	-0.1	0.1	0.1	0.6	-0.6	0.3
Intermittent access total infusions	0.4	0.5	0.9	0.8	-0.6	0.7	-0.7	-0.6	0.6	0.9	-0.7	0.3
Intermittent access day 1 locomotion	0.2	0.2	0.5	0.7	-0.5	0.5	-0.5	-0.6	0.3	0.5	-0.2	-0.2
Intermittent access day 15 total locomotion	1.6	1.8	3.7	-1.3	1.7	-1.5	1.5	1.9	-1.5	0.1	-0.8	-0.2
Intermittent access total locomotion	0.1	0.1	0.4	0.3	0.1	-0.1	0.1	0.3	-0.3	0.2	0.0	-0.6
Intermittent access standard deviation	0.5	0.6	1.6	0.4	-0.3	0.4	-0.5	-0.1	0.7	1.0	-1.3	1.3
Left kidney weight	3.1	8.7	12.1	3.5	-3.2	3.4	-3.4	-2.8	3.3	2.8	-1.6	1.9
Right kidney weight	3.4	9.7	12.9	3.6	-3.4	3.5	-3.5	-3.1	3.5	2.9	-1.7	2.1
Cocaine induced anxiety	0.3	0.3	0.5	-0.3	0.4	-0.4	0.4	0.6	-0.6	-0.7	0.7	-0.6
Post-drug Anxiety	0.6	0.6	1.1	-0.8	1.0	-0.9	0.9	1.0	-0.8	0.1	-0.7	0.3
Baseline Anxiety	1.3	1.4	5.0	0.3	-0.3	0.5	-0.5	-0.4	0.9	1.7	-2.2	1.8
Tail length	2.0	6.1	7.5	2.7	-2.7	2.7	-2.7	-2.7	2.7	2.3	-1.4	1.6
Length with tail	0.5	1.9	2.8	1.2	-1.2	1.3	-1.4	-1.3	1.5	1.7	-1.5	1.3
Length without tail	0.4	0.8	1.5	-1.2	1.1	-1.0	1.0	1.1	-0.6	0.0	-0.9	0.5
Times rat made contact with spout	2.3	2.6	4.1	1.7	-1.8	1.9	-1.9	-1.3	2.0	1.4	-0.9	1.5
Lifetime Intake	0.9	1.0	1.5	1.2	-1.0	1.1	-1.1	-1.1	1.0	1.1	-0.7	0.4
Liver weight, left	0.2	0.3	0.6	0.5	-0.5	0.4	-0.4	-0.7	0.2	-0.3	0.6	-0.8
Liver weight, right	0.9	1.5	3.7	1.0	-1.2	0.9	-0.8	-1.5	0.4	-1.1	1.9	-1.5
Locomotor activity	0.1	0.2	0.7	-0.0	-0.1	-0.1	0.1	-0.2	-0.3	-0.6	0.6	-0.8
Locomotor testing distance	0.0	0.0	0.1	0.3	-0.3	0.2	-0.2	-0.2	0.0	-0.0	0.1	-0.4
Locomotor testing rearing	0.3	0.5	1.5	-0.3	0.2	-0.4	0.4	-0.0	-0.7	-1.0	1.0	-1.2
Locomotion in novel chamber	0.2	0.2	0.6	0.7	-0.5	0.4	-0.4	-0.5	0.0	-0.2	0.6	-0.7
Locomotion in novel chamber post-restriction	0.9	1.1	1.9	-0.9	1.2	-1.2	1.2	1.1	-1.4	-0.8	0.3	-0.9
Fecal boli incidents, locomotor time 1	1.4	1.6	5.1	-0.3	0.1	-0.4	0.4	-0.5	-0.8	-1.8	2.2	-2.2
Change in fecal boli incidents, locomotor task	1.2	1.1	5.1	-0.1	0.4	-0.1	0.1	0.4	0.1	1.6	-2.2	1.5
Time >=10cm from walls, locomotor time 1	1.2	1.3	1.7	1.2	-1.1	1.2	-1.2	-0.9	1.3	1.3	-0.8	1.0
Bouts of movement, locomotor time 1	3.2	3.4	4.6	-1.9	1.9	-2.0	2.0	1.6	-2.1	-1.9	1.5	-1.7
Total resting periods, locomotor time 1	3.5	3.9	4.9	-2.0	2.0	-2.1	2.1	1.6	-2.2	-2.1	1.6	-1.8
Rest time, locomotor task time 1	0.3	0.3	0.9	-0.9	0.6	-0.6	0.6	0.4	-0.4	-0.4	0.0	0.1
Distance moved, locomotor task time 1	0.6	0.7	1.4	1.2	-0.9	0.9	-0.9	-0.4	0.7	1.0	-0.6	0.5
Vertical activity count, locomotor time 1	2.7	2.8	4.9	1.7	-1.3	1.5	-1.6	-0.5	1.6	2.2	-2.0	2.1
Time >=10cm from walls, locomotor time 2	3.4	3.6	5.0	2.0	-2.0	2.1	-2.1	-1.7	2.2	1.9	-1.2	1.5
Bouts of movement, locomotor time 2	1.8	1.9	6.9	0.8	-1.0	0.6	-0.6	-1.4	0.1	-1.6	2.6	-1.9
Total resting periods, locomotor time 2	1.7	1.8	5.7	0.9	-1.2	0.8	-0.8	-1.6	0.3	-1.4	2.4	-1.7
Rest time, locomotor task time 2	0.1	0.1	0.3	-0.1	0.0	0.0	-0.0	-0.0	0.1	0.4	-0.5	0.3
Distance moved, locomotor task time 2	0.9	1.1	2.2	0.9	-0.8	1.0	-1.0	-0.3	1.2	1.2	-1.1	1.5
Vertical activity count, locomotor time 2	1.7	1.8	5.0	0.7	-0.4	0.7	-0.8	0.3	1.1	1.9	-2.2	2.2
Light reinforcement 1	0.4	0.7	1.7	-0.6	0.7	-0.8	0.8	0.4	-1.0	-0.9	0.8	-1.3
Light reinforcement 2	0.2	0.2	0.8	-0.2	0.3	-0.3	0.3	0.2	-0.6	-0.5	0.5	-0.9
Bone: marrow area	1.4	3.0	5.0	2.1	-2.2	2.1	-2.1	-2.2	1.8	0.6	0.5	0.1
Bone: maximum diameter	1.8	3.3	5.0	2.2	-2.2	2.2	-2.2	-2.0	2.0	1.2	-0.4	0.8
Bone: maximum force	4.3	7.4	9.9	3.1	-3.0	3.1	-3.1	-2.6	3.1	2.5	-1.5	1.9
Bone: maximum moment	3.3	5.8	7.7	2.8	-2.6	2.7	-2.7	-2.3	2.7	2.3	-1.3	1.7
Mean time between licks in bursts	0.3	0.4	1.4	0.0	-0.0	-0.1	0.1	-0.2	-0.3	-1.0	1.2	-0.9
Mean num. licks in bursts	6.2	7.4	10.5	3.2	-3.1	3.2	-3.2	-3.0	3.0	2.3	-1.0	1.5
Cd content in liver	5.4	5.9	8.4	-2.8	2.9	-2.9	2.9	2.5	-2.9	-1.7	0.6	-1.6
Co content in liver	1.2	1.4	2.7	-1.2	1.4	-1.2	1.2	1.6	-1.0	0.4	-1.2	0.6
Cu content in liver	0.2	0.2	0.9	0.1	0.1	0.0	-0.0	0.3	0.0	0.8	-0.9	0.7
Fe content in liver	1.0	1.2	2.6	-1.1	1.3	-1.1	1.1	1.6	-0.8	0.4	-1.2	0.7
K content in liver	0.1	0.1	0.3	0.2	-0.1	0.0	-0.0	-0.0	-0.2	-0.4	0.6	-0.4
Mg content in liver	1.2	1.3	4.3	-0.2	0.2	-0.4	0.4	-0.2	-0.8	-1.7	2.1	-1.8
Mn content in liver	0.3	0.4	0.6	0.7	-0.8	0.7	-0.7	-0.8	0.6	-0.1	0.5	0.0
Na content in liver	5.2	5.5	8.8	2.8	-3.0	2.8	-2.8	-2.9	2.6	0.9	0.4	0.6
Rb content in liver	1.5	1.9	3.1	-1.5	1.7	-1.7	1.7	1.7	-1.7	-0.4	-0.2	-0.6
Se content in liver	0.1	0.2	0.3	0.5	-0.4	0.5	-0.5	-0.2	0.5	0.4	-0.2	0.4
Sr content in liver	0.5	0.4	0.7	0.8	-0.8	0.8	-0.8	-0.8	0.7	0.2	0.1	0.1
Zn content in liver	2.2	2.4	4.3	2.0	-2.0	1.8	-1.8	-2.1	1.5	0.4	0.7	0.0
Bone: minimum diameter	2.0	3.8	5.7	2.3	-2.4	2.3	-2.3	-2.4	2.2	1.1	-0.1	0.6
Time in familiar zone, hab. session 1	1.2	1.1	2.7	-1.0	1.3	-1.0	1.0	1.7	-0.8	0.5	-1.2	0.7
Time in novel zone, hab. session 1	1.6	1.6	4.7	1.1	-1.5	1.2	-1.2	-2.2	1.0	-0.3	1.2	-0.8
Total zone transitions, hab. session 1	2.4	3.4	5.5	1.9	-1.6	1.9	-1.9	-1.3	1.9	2.3	-1.8	1.8
Total locomotion distance, hab. session 1	4.0	5.7	7.3	2.7	-2.4	2.6	-2.6	-2.1	2.5	2.7	-1.9	2.0
Locomotion velocity, hab. session 1	2.7	3.8	5.6	2.4	-2.0	2.2	-2.2	-1.7	2.0	2.1	-1.4	1.5
Time in familiar zone, hab. session 2	0.3	0.3	0.6	0.5	-0.4	0.5	-0.5	-0.1	0.5	0.7	-0.7	0.7
Time in novel zone, hab. session 2	0.1	0.1	0.4	-0.2	0.1	-0.2	0.2	-0.0	-0.3	-0.4	0.5	-0.6
Total zone transitions, hab. session 2	1.7	2.2	3.1	1.7	-1.5	1.6	-1.6	-1.3	1.6	1.8	-1.2	1.1
Total locomotion distance, hab. session 2	2.7	3.5	5.3	1.9	-1.7	1.9	-1.9	-1.3	2.0	2.3	-1.8	1.8
Locomotion velocity, hab. session 2	3.1	4.1	5.4	2.2	-2.0	2.2	-2.2	-1.6	2.2	2.3	-1.7	1.8
Novel to familiar place preference ratio	0.9	0.9	2.0	-1.1	1.2	-1.1	1.1	1.4	-0.9	-0.3	-0.3	0.3
Novelty place preference	0.9	0.9	2.2	-1.1	1.2	-1.0	1.0	1.5	-0.8	-0.0	-0.6	0.5
Time in novel zone, NPP test	0.9	0.9	2.1	-1.1	1.2	-1.1	1.1	1.4	-0.9	-0.1	-0.5	0.3
Total zone transitions, NPP test	1.4	2.1	2.6	1.6	-1.4	1.6	-1.6	-1.2	1.6	1.6	-1.1	1.1
Total locomotion distance, NPP test	1.7	2.3	3.6	1.5	-1.3	1.5	-1.5	-0.8	1.6	1.9	-1.6	1.8
Locomotion velocity, NPP test	1.5	2.1	3.4	1.4	-1.2	1.4	-1.4	-0.8	1.5	1.8	-1.6	1.7
Intraocular pressure	0.2	0.3	0.7	0.6	-0.7	0.6	-0.6	-0.8	0.4	-0.2	0.6	-0.3
Delta distance traveled before/after self-admin	1.3	1.4	2.4	1.4	-1.5	1.4	-1.4	-1.3	1.3	0.5	0.2	0.2
Delta ambulatory time before/after self-admin	1.1	1.2	1.9	1.3	-1.4	1.3	-1.3	-1.1	1.3	0.7	-0.2	0.5
Parametrial fat weight	1.7	3.3	5.3	2.3	-1.9	2.1	-2.1	-1.6	1.9	2.0	-1.2	0.9
Pavlov. Cond. lever latency	2.3	2.9	7.8	-1.4	1.7	-1.3	1.2	2.2	-0.7	1.5	-2.8	1.8
Pavlov. Cond. magazine entry latency	3.3	4.3	8.3	2.1	-2.4	2.0	-1.9	-2.9	1.3	-1.1	2.7	-1.6
Pavlov. Cond. change in total contacts	2.7	2.8	6.2	1.4	-1.8	1.4	-1.4	-2.3	1.0	-1.4	2.5	-1.2
Pavlov. Cond. index score	3.2	4.0	10.5	1.6	-2.0	1.5	-1.5	-2.6	0.8	-1.8	3.2	-2.1
Pavlov. Cond. latency score	2.8	3.5	9.0	1.6	-1.9	1.4	-1.4	-2.4	0.8	-1.6	3.0	-1.9
Pavlov. Cond. lever contacts	3.3	3.9	8.9	1.7	-2.1	1.6	-1.6	-2.6	1.0	-1.5	3.0	-1.8
Pavlov. Cond. magazine entry number	2.9	3.6	8.3	-1.6	2.0	-1.6	1.5	2.6	-1.0	1.5	-2.9	1.6
Pavlov. Cond. intertrial magazine entries	1.8	2.2	4.5	-1.6	1.8	-1.6	1.6	2.1	-1.4	0.3	-1.3	0.3
Pavlov. Cond. lever-magazine prob. diff.	3.6	4.5	10.8	1.9	-2.2	1.7	-1.7	-2.8	1.0	-1.7	3.3	-2.1
Pavlov. Cond. response bias	3.4	4.2	9.6	1.7	-2.2	1.7	-1.7	-2.7	1.1	-1.6	3.1	-1.8
Pavlov. Cond. lever latency	0.5	0.7	1.3	-1.1	1.0	-1.0	1.0	1.1	-0.8	-0.5	0.0	-0.1
Pavlov. Cond. magazine entry latency	0.9	1.0	2.2	-0.9	0.7	-0.8	0.8	0.2	-0.9	-1.5	1.4	-1.1
Pavlov. Cond. change in total contacts	0.3	0.4	0.7	-0.5	0.7	-0.7	0.7	0.6	-0.9	-0.2	-0.0	-0.5
Pavlov. Cond. index score	0.2	0.2	0.6	-0.2	0.1	-0.2	0.2	-0.1	-0.4	-0.6	0.7	-0.7
Pavlov. Cond. latency score	0.1	0.1	0.4	0.0	-0.1	-0.0	0.0	-0.3	-0.1	-0.5	0.6	-0.6
Pavlov. Cond. lever contacts	0.6	0.9	1.8	1.2	-1.2	1.1	-1.1	-1.3	0.8	0.2	0.4	-0.3
Pavlov. Cond. magazine entry number	1.7	2.1	2.7	1.7	-1.6	1.6	-1.6	-1.2	1.6	1.5	-1.0	1.2
Pavlov. Cond. intertrial magazine entries	1.8	2.4	4.2	2.0	-2.0	1.9	-1.9	-1.9	1.6	0.7	0.2	0.3
Pavlov. Cond. lever-magazine prob. diff.	0.3	0.3	0.9	-0.3	0.2	-0.4	0.4	-0.1	-0.5	-0.9	1.0	-0.9
Pavlov. Cond. response bias	0.1	0.2	0.6	0.2	-0.2	0.1	-0.1	-0.4	-0.2	-0.5	0.8	-0.7
Time in closed arm before self-admin	0.7	0.8	1.3	0.9	-0.7	0.9	-0.9	-0.6	0.9	1.1	-0.9	0.8
Time in closed arm after self-admin	1.0	1.0	1.7	-1.2	1.3	-1.2	1.2	1.2	-1.1	-0.2	-0.5	-0.1
Time in open arm before self-admin	2.0	2.2	2.7	-1.6	1.5	-1.6	1.6	1.2	-1.6	-1.6	1.3	-1.3
Time in open arm after self-admin	1.3	1.4	2.1	1.4	-1.4	1.4	-1.4	-1.0	1.4	0.8	-0.3	0.9
Bone: periosteal estimation	3.0	6.1	8.9	3.0	-3.0	3.0	-3.0	-2.8	2.8	1.7	-0.5	1.1
Bone: periosteal perimeter	1.5	2.5	4.1	2.0	-2.0	1.9	-1.9	-2.0	1.7	0.6	0.3	0.1
Bone: post-yield work	1.3	1.7	3.5	1.7	-1.6	1.5	-1.5	-1.9	1.1	0.4	0.5	-0.5
Progressive ratio test 1 active lever presses	0.1	0.1	0.3	0.5	-0.4	0.4	-0.4	-0.5	0.2	0.1	0.3	-0.5
Progressive ratio test 1 breakpoint	0.1	0.1	0.2	0.5	-0.4	0.3	-0.3	-0.4	0.1	0.1	0.3	-0.5
Progressive ratio test 1 inactive lever presses	0.3	0.3	0.6	0.8	-0.6	0.6	-0.6	-0.6	0.5	0.5	-0.1	0.1
Progressive ratio test 2 active lever presses	0.1	0.1	0.2	0.3	-0.3	0.2	-0.2	-0.4	0.1	0.3	-0.0	-0.3
Progressive ratio test 2 breakpoint	0.1	0.1	0.2	0.3	-0.2	0.2	-0.2	-0.4	0.0	0.2	0.1	-0.5
Progressive ratio test 2 inactive lever presses	0.0	0.0	0.2	-0.0	0.1	-0.1	0.1	0.1	-0.3	0.0	0.1	-0.5
Incentive Sensitization - Responses	0.2	0.2	0.9	0.2	-0.3	0.1	-0.1	-0.4	-0.0	-0.3	0.9	-0.9
Incentive Sensitization - Breakpoint	0.2	0.2	0.8	0.2	-0.3	0.2	-0.2	-0.4	0.0	-0.3	0.8	-0.9
Sum of active levers in priming session hrs 5-6	0.6	0.6	2.0	-0.2	0.2	-0.3	0.4	0.1	-0.6	-1.1	1.3	-1.4
Progressive ratio	0.3	0.4	0.7	-0.6	0.7	-0.7	0.7	0.8	-0.6	0.2	-0.6	0.0
Food seeking constrained by brief footshock	1.2	1.5	2.4	-1.6	1.6	-1.5	1.5	1.6	-1.2	-0.4	-0.5	0.1
Seeking ratio, punishment vs. effort	0.2	0.3	0.6	0.4	-0.6	0.5	-0.5	-0.8	0.4	-0.3	0.6	-0.2
Retroperitoneal fat weight	0.0	0.2	0.9	0.1	0.1	-0.2	0.2	0.1	-0.6	-0.2	0.3	-0.9
Reaction time number correct	0.9	1.3	2.1	-1.1	1.0	-1.1	1.1	0.6	-1.2	-1.3	1.0	-1.5
Reaction time mean minus median	0.1	0.1	0.3	0.4	-0.2	0.3	-0.3	0.1	0.3	0.4	-0.2	0.6
Reaction time mean minus median AUC	0.1	0.2	0.4	-0.3	0.5	-0.5	0.5	0.7	-0.5	-0.1	0.2	-0.2
Reaction time num false alarms	0.5	0.7	2.2	-1.0	1.0	-0.8	0.8	1.5	-0.5	-0.0	-0.6	0.7
Reaction time num false alarms AUC	0.3	0.4	1.1	-0.8	0.7	-0.7	0.7	1.0	-0.5	-0.4	-0.0	0.2
Reaction time trials correct on left	0.9	1.3	2.1	-1.1	1.0	-1.1	1.1	0.6	-1.2	-1.3	1.0	-1.5
Reaction time trials on left	0.9	1.3	2.3	-1.1	1.0	-1.1	1.1	0.5	-1.2	-1.3	1.1	-1.5
Reaction time mean	0.1	0.2	0.4	0.6	-0.5	0.5	-0.5	-0.5	0.3	0.2	0.2	0.2
Reaction time mean AUC	0.1	0.1	0.4	0.4	-0.4	0.3	-0.3	-0.4	0.1	-0.2	0.6	-0.2
Median of all reaction times	0.2	0.2	0.4	0.7	-0.6	0.5	-0.5	-0.6	0.3	-0.0	0.4	-0.1
Reaction time omissions	0.8	1.1	3.6	-0.3	0.1	-0.4	0.4	-0.3	-0.7	-1.5	1.9	-1.7
Reaction time false alarm rate	0.2	0.2	1.2	-0.1	0.1	0.1	-0.1	0.6	0.3	0.4	-0.7	1.1
Reaction time premature initiation rate	1.8	2.4	3.5	1.6	-1.7	1.7	-1.7	-1.5	1.9	1.2	-0.7	1.4
Reaction time premature initiations	0.5	0.7	1.3	0.8	-1.1	1.0	-1.0	-1.1	1.1	0.3	-0.0	0.5
Std. dev. reaction times	0.1	0.1	0.3	0.5	-0.3	0.4	-0.4	-0.2	0.3	0.4	-0.1	0.3
Reaction time trials completed	0.9	1.3	2.3	-1.1	1.0	-1.1	1.1	0.5	-1.2	-1.3	1.1	-1.5
Reaction time trials AUC	0.7	0.9	1.7	-0.9	0.8	-0.9	1.0	0.5	-1.0	-1.1	0.9	-1.3
Run reversals in cocaine runway, females	6.8	6.6	8.6	2.6	-2.6	2.8	-2.8	-2.3	2.9	2.5	-2.0	2.5
Run reversals in cocaine runway, males	0.2	0.2	0.4	-0.5	0.5	-0.4	0.4	0.6	-0.2	0.2	-0.4	0.3
Latency to leave start box in cocaine runway	0.3	0.3	0.6	-0.6	0.8	-0.7	0.7	0.7	-0.7	0.1	-0.3	-0.3
Latency to leave start box in cocaine runway, F	0.5	0.5	1.5	-0.4	0.4	-0.5	0.5	0.1	-0.7	-0.8	1.1	-1.2
Latency to leave start box in cocaine runway, M	0.9	0.9	2.4	-0.6	0.9	-0.7	0.7	1.2	-0.4	1.1	-1.6	0.8
Std. dev. time between licks in bursts	0.4	0.5	1.8	0.4	-0.3	0.2	-0.2	-0.3	-0.2	-1.0	1.4	-1.1
Total sessions with >9 infusions	4.8	5.3	6.5	2.4	-2.4	2.5	-2.5	-2.4	2.5	2.3	-1.7	1.8
Short access day 1 total inactive lever presses	0.1	0.2	0.8	-0.1	0.2	-0.1	0.1	0.0	0.0	0.5	-0.9	0.5
Short access day 10 total inactive lever presses	0.8	0.9	1.6	-1.1	1.1	-0.9	0.9	1.2	-0.6	0.3	-1.3	0.9
Short access day 1 total infusions	1.1	1.1	2.3	0.9	-0.8	0.9	-0.9	-1.0	1.0	1.4	-1.5	1.0
Short access day 10 total infusions	1.6	1.8	2.3	1.5	-1.5	1.5	-1.5	-1.5	1.5	1.2	-0.7	0.7
Short access total infusions	1.7	1.9	2.4	1.6	-1.4	1.5	-1.5	-1.5	1.4	1.5	-1.1	0.7
Short access day 1 locomotion	0.5	0.5	1.8	0.3	-0.2	0.4	-0.4	-0.3	0.5	1.0	-1.4	0.9
Short access day 10 total locomotion	0.9	1.0	2.1	1.4	-1.3	1.2	-1.2	-1.2	0.8	0.3	0.6	-0.4
Short access total locomotion	0.6	0.6	1.2	1.0	-0.7	0.8	-0.8	-0.8	0.6	1.1	-0.8	0.2
One hour access (0.3 mA shock)	0.9	1.0	2.2	1.5	-1.2	1.2	-1.2	-1.2	0.8	0.5	0.4	-0.4
Compulsive drug intake	0.7	0.7	2.7	0.1	-0.1	-0.1	0.1	-0.3	-0.5	-1.1	1.6	-1.5
One hour access (shock baseline)	0.2	0.2	0.7	-0.3	0.5	-0.3	0.3	0.6	-0.2	0.5	-0.9	0.5
Social response proportion	0.6	0.7	1.4	-0.6	0.7	-0.8	0.8	0.6	-1.0	-0.8	0.8	-1.2
Social responses	1.2	1.6	2.9	-1.0	1.0	-1.1	1.1	0.8	-1.4	-1.5	1.5	-1.7
Social time	1.2	1.6	2.3	-1.5	1.5	-1.5	1.5	1.2	-1.4	-0.8	0.5	-0.8
Soleus weight	2.1	6.2	9.4	2.4	-2.2	2.5	-2.5	-1.6	2.7	3.1	-2.6	2.7
Bone: stiffness	4.0	6.3	8.2	2.7	-2.5	2.7	-2.8	-1.9	2.9	2.6	-1.9	2.3
Tibialis anterior weight	6.2	21.2	27.7	5.2	-5.0	5.2	-5.2	-4.3	5.3	4.4	-2.7	3.5
Time to tail flick, vehicle, before self-admin	0.2	0.2	0.3	0.5	-0.5	0.5	-0.5	-0.5	0.5	0.1	-0.1	0.4
Time to tail flick, vehicle, after self-admin	1.3	1.4	2.8	-0.9	0.8	-1.0	1.0	0.4	-1.1	-1.5	1.6	-1.7
Time to tail flick, test, before self-admin	0.2	0.2	0.5	0.4	-0.4	0.5	-0.5	-0.4	0.6	0.3	-0.3	0.7
Time to tail flick, test, after self-admin	0.5	0.6	2.4	-0.3	0.1	-0.3	0.3	0.2	-0.4	-1.2	1.5	-0.9
Delta time to tail flick, vehicle, before/after SA	0.6	0.6	1.9	-0.3	0.3	-0.4	0.4	0.1	-0.6	-0.9	1.2	-1.4
Delta time to tail flick, test, before/after SA	0.4	0.3	1.5	0.1	-0.1	-0.0	0.0	-0.1	-0.2	-0.7	1.2	-1.0
Tibia length	0.1	0.4	1.2	-0.5	0.6	-0.5	0.5	0.8	-0.3	0.6	-1.1	0.7
Ambulatory time before self-admin	0.8	0.9	3.3	-0.2	0.3	-0.1	0.0	0.3	0.3	1.3	-1.8	1.5
Ambulatory time after self-admin	2.8	3.1	4.7	1.5	-1.5	1.7	-1.7	-1.4	2.0	1.9	-1.8	2.2
Bone: tissue strength	0.1	0.1	0.2	0.2	-0.2	0.3	-0.3	-0.2	0.4	0.3	-0.2	0.4
Total heroin consumption	1.1	1.3	2.9	-0.9	0.9	-1.0	1.0	0.4	-1.3	-1.2	1.3	-1.7
Bone: trabecular number	0.6	0.9	1.4	1.0	-0.8	1.0	-1.0	-0.6	1.0	1.2	-0.9	1.0
Bone: trabecular spacing	1.4	1.8	5.0	-0.7	0.5	-0.7	0.8	-0.0	-1.1	-2.0	2.2	-2.1
Bone: trabecular thickness	1.6	2.0	5.2	1.1	-0.7	1.0	-1.0	-0.3	1.1	2.2	-2.3	1.8
Bone: trabecular tissue density	0.1	0.2	0.6	-0.0	0.1	-0.0	0.0	0.4	0.1	0.5	-0.8	0.7
Water consumed over 24 hours	0.0	0.1	0.3	-0.3	0.1	-0.0	0.0	0.1	0.3	0.0	-0.1	0.6
Number of responses in last shaping day	0.5	0.5	0.8	0.7	-0.8	0.7	-0.7	-0.9	0.8	0.5	-0.5	0.5