Hub : Genes

Vps35l

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	gene expression	Vps35l	0.04	0.03	1.6e-04	0.01	0.01	0.01	0.01	1.3e-02	1.6e-02	5.6e-02	1.7e-02
2	Adipose	mRNA stability	Vps35l	0.06	0.04	3.6e-05	0.03	0.01	0.01	0.02	6.5e-04	7.9e-03	2.8e-02	5.9e-03
3	Brain	gene expression	Vps35l	0.05	0.03	7.4e-04	0.04	0.03	0.03	0.03	1.2e-04	2.1e-03	9.7e-04	5.2e-04
4	BLA	gene expression	Vps35l	0.13	0.09	5.7e-04	0.03	0.03	0.03	0.03	1.7e-02	1.6e-02	1.3e-02	7.8e-03
5	PL	gene expression	Vps35l	0.07	0.05	7.8e-05	0.03	0.04	0.03	0.04	3.4e-04	6.2e-05	4.0e-04	7.5e-05
6	NAcc	gene expression	Vps35l	0.06	0.03	1.2e-07	0.04	0.05	0.05	0.05	1.5e-06	1.0e-07	6.9e-08	6.3e-08

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bone: apparent density	0.5	1.0	3.1	1.6	1.8	0.2	-0.2	0.2	-0.0
Area under the delay curve	0.1	0.2	0.3	-0.3	-0.3	-0.5	0.5	0.2	-0.5
BMI with tail	2.1	7.2	16.3	4.0	3.9	2.3	-2.3	-0.9	0.2
BMI without tail	1.7	9.0	23.8	4.9	4.7	1.9	-1.9	-0.0	0.8
Body weight	1.2	5.3	13.9	3.7	3.6	1.4	-1.4	0.2	0.7
Weight adjusted by age	0.1	0.4	1.1	0.4	0.2	0.7	-0.7	-0.3	1.1
Bone surface	0.7	1.4	3.2	1.6	1.8	0.9	-0.9	-0.7	-0.6
Bone volume	1.0	2.0	5.3	2.1	2.3	0.9	-0.9	-0.4	-0.5
Breakpoint value in progressive ratio session	0.9	1.6	2.2	-1.4	-1.5	-1.1	1.0	1.1	1.3
Number of licking bursts	0.9	2.7	7.2	-2.7	-2.5	0.1	-0.1	-1.0	-1.3
Context. condit. distance diff. score	0.3	0.4	0.7	-0.7	-0.7	-0.4	0.4	0.5	0.8
Locomotion velocity, session 1	0.2	0.2	0.8	0.1	0.4	0.0	-0.0	-0.4	-0.9
Locomotion distance, session 1	0.5	0.6	1.5	1.2	1.2	-0.4	0.4	0.5	0.6
Locomotion velocity, session 2	0.2	0.2	0.7	-0.2	0.2	-0.4	0.4	-0.1	-0.8
Locomotion distance, session 2	1.0	1.4	3.9	1.8	2.0	0.5	-0.5	-0.5	-0.6
Locomotion velocity, session 3	0.2	0.2	0.8	0.7	0.9	0.2	-0.2	0.0	0.0
Locomotion distance, session 3	1.1	1.2	2.1	0.3	0.3	1.4	-1.4	-1.4	-1.2
Stereotopy head waving bouts, day 3	1.0	1.1	1.8	-0.8	-0.8	-1.4	1.4	1.1	0.8
Stereotopy head waving duration, day 3	0.8	1.0	1.5	-0.3	-0.3	-1.2	1.2	1.2	1.1
Locomotion velocity, session 7	1.9	2.1	3.5	1.1	1.1	1.9	-1.9	-1.5	-0.9
Locomotion distance, session 7	1.1	1.4	2.3	-0.0	-0.3	1.4	-1.4	-1.5	-1.3
Stereotopy head waving bouts, day 7	0.3	0.4	0.7	0.3	0.6	-0.6	0.6	0.8	0.6
Stereotopy head waving duration, day 7	0.8	1.0	3.2	1.4	1.8	0.2	-0.2	0.4	0.7
Locomotion velocity, session 8	0.1	0.1	0.2	0.1	0.3	-0.4	0.4	0.2	-0.2
Locomotion distance, session 8	0.1	0.1	0.4	0.5	0.6	0.1	-0.1	-0.0	0.1
Degree of sensitization distance	0.8	0.9	1.6	-0.2	-0.5	-1.2	1.2	1.3	0.8
Degree of sensitization stereotypy	0.7	0.8	2.8	1.3	1.7	0.4	-0.4	-0.1	-0.1
Conditioned locomotion	0.5	0.6	1.0	-1.0	-0.8	0.5	-0.5	-1.0	-0.5
Cocaine response after cond. corrected	0.1	0.1	0.2	-0.5	-0.4	0.0	-0.0	-0.2	-0.3
Cocaine response after cond. not corrected	0.2	0.3	0.5	0.3	0.3	0.7	-0.7	-0.5	-0.5
Cocaine response before conditioning	2.1	2.5	3.3	1.7	1.8	1.8	-1.8	-1.1	-0.9
Saline control response	0.4	0.6	0.8	-0.3	-0.6	-0.9	0.9	0.9	0.8
Bone: connectivity density	0.4	0.6	1.9	1.1	1.4	0.4	-0.4	-0.1	0.2
Bone: cortical apparent density	0.4	0.6	1.6	-1.1	-1.3	-0.2	0.2	-0.1	-0.6
Bone: cortical area	1.9	3.1	7.2	2.7	2.5	1.5	-1.5	-0.6	-0.9
Bone: cortical porosity	0.4	0.5	0.9	0.9	0.9	0.3	-0.3	0.4	0.9
Bone: cortical porosity	0.4	0.4	1.7	0.4	0.4	-0.0	0.0	0.8	1.3
Bone: cortical thickness	0.8	1.3	3.1	1.8	1.6	0.4	-0.4	-0.2	-1.1
Bone: cortical thickness	0.5	0.7	1.9	0.9	0.9	-0.4	0.4	0.1	-1.4
Bone: cortical tissue density	0.4	0.6	1.7	-1.1	-1.3	-0.2	0.2	-0.1	-0.5
Condit. Reinf. active minus inactive responses	0.3	0.4	0.9	-0.4	-0.5	-0.5	0.5	0.8	1.0
Condit. Reinf. active-inactive response ratio	0.2	0.2	1.1	-0.2	-0.2	0.1	-0.1	0.5	1.0
Condit. Reinf. active responses	0.3	0.4	0.6	-0.3	-0.4	-0.8	0.8	0.7	0.6
Condit. Reinf. inactive responses	0.2	0.2	0.5	0.0	-0.1	-0.7	0.7	0.3	-0.1
Incentive salience index mean	0.1	0.2	0.4	0.0	0.1	0.6	-0.6	-0.4	0.2
Condit. Reinf. lever presses	0.4	0.6	1.3	-0.1	0.0	1.1	-1.1	-1.1	-0.3
Condit. Reinf. active minus inactive responses	1.0	1.5	4.0	0.9	0.8	-0.9	0.9	1.5	2.0
Condit. Reinf. active-inactive response ratio	1.0	1.6	3.9	0.1	0.0	-1.2	1.2	1.7	2.0
Condit. Reinf. active responses	0.5	0.8	2.1	0.9	0.9	-0.3	0.3	0.9	1.5
Condit. Reinf. inactive responses	1.1	1.6	2.4	1.1	1.3	1.5	-1.5	-1.1	-0.8
Condit. Reinf. lever presses	0.7	1.0	2.2	1.5	1.5	0.3	-0.3	0.6	1.1
Condit. Reinf. lever reinforcers received	0.6	0.8	2.6	0.5	0.5	-0.5	0.5	1.1	1.6
Conditioned reinforcement - actives	0.0	0.1	0.3	0.1	0.3	-0.2	0.2	0.5	-0.1
Conditioned reinforcement - inactives	0.1	0.3	0.8	-0.9	-0.8	-0.2	0.2	-0.1	-0.5
Conditioned locomotion	0.0	0.0	0.1	-0.3	-0.1	0.2	-0.2	-0.1	-0.2
Patch foraging indifference point 0 sec	0.5	1.4	3.6	0.8	0.5	-1.0	1.0	1.9	1.5
Patch foraging indifference point AUC	0.2	0.4	1.2	1.1	0.9	0.3	-0.3	-0.1	-0.4
Delay disc. indifference point, 0s delay	2.0	2.2	4.5	1.1	1.2	1.4	-1.4	-1.5	-2.1
Delay disc. indifference point, 16s delay	2.7	3.8	5.6	-2.3	-2.4	-2.1	2.1	1.6	0.8
Delay disc. indifference point, 2s delay	3.1	3.5	5.9	2.4	2.4	1.6	-1.6	-1.2	-1.5
Delay disc. indifference point, 24s delay	1.4	2.2	5.0	-2.2	-2.1	-1.3	1.3	0.6	0.1
Delay disc. indifference point, 4s delay	0.3	0.3	1.3	0.3	0.4	-0.3	0.3	0.1	-1.1
Delay disc. indifference point, 8s delay	0.1	0.2	0.8	0.1	0.2	0.2	-0.2	-0.4	-0.9
Indifference point function ln k	0.0	0.1	0.3	0.4	0.5	0.1	-0.1	0.0	-0.2
Indifference point function log k	0.0	0.1	0.3	0.4	0.5	0.1	-0.1	0.0	-0.2
Patch foraging total patch changes 0 sec	0.6	1.8	4.4	0.8	0.6	-1.1	1.1	2.1	1.7
Patch foraging total patch changes 12 sec	0.1	0.2	0.4	0.6	0.3	-0.0	0.0	0.4	0.6
Patch foraging total patch changes 18 sec	0.1	0.2	0.5	0.2	0.0	-0.6	0.6	0.7	0.3
Patch foraging total patch changes 24 sec	0.2	0.7	1.5	1.0	0.9	-0.3	0.3	1.2	0.9
Patch foraging total patch changes 6 sec	2.0	3.4	7.6	-0.1	-0.2	-2.3	2.3	2.8	1.6
Patch foraging time to switch 0 sec	0.4	1.7	4.6	-2.1	-1.9	0.5	-0.5	-1.2	-0.2
Patch foraging water rate 0 sec	0.0	0.2	0.5	0.7	0.6	0.0	-0.0	0.3	0.3
Patch foraging water rate 12 sec	0.3	1.3	2.4	1.3	1.2	-0.9	0.9	1.5	0.8
Patch foraging water rate 18 sec	0.4	0.8	1.8	0.5	0.6	-0.8	0.8	1.3	1.1
Patch foraging water rate 24 sec	0.2	0.3	0.8	0.9	0.7	0.1	-0.1	0.2	-0.4
Patch foraging water rate 6 sec	0.1	0.2	0.5	0.2	0.2	-0.6	0.6	0.7	-0.2
Seeking ratio, delayed vs. immediate footshock	0.0	0.1	0.2	0.3	0.3	0.1	-0.1	0.1	0.4
Distance traveled before self-admin	0.1	0.2	0.4	0.4	0.6	0.3	-0.3	-0.3	-0.7
Distance traveled after self-admin	1.6	2.9	3.6	1.6	1.7	1.7	-1.7	-1.5	-1.9
Extensor digitorum longus weight	4.4	17.5	23.4	4.8	4.8	4.4	-4.4	-3.4	-2.9
Bone: elastic displacement	0.7	0.9	1.5	-0.8	-0.6	-1.2	1.2	1.2	0.6
Bone: elastic work	0.2	0.3	0.9	0.8	1.0	0.2	-0.2	0.2	-0.3
Bone: endosteal estimation	1.2	2.9	4.1	2.0	1.9	2.0	-2.0	-1.3	-0.3
Bone: endosteal perimeter	1.2	3.0	5.0	1.5	1.3	2.2	-2.2	-1.8	-0.8
Epididymis fat weight	0.3	1.6	4.4	2.1	1.9	0.2	-0.2	0.7	1.1
Delta time in closed arm before/after self-admin	1.8	1.7	3.1	0.4	0.1	1.7	-1.7	-1.6	-1.1
Delta time in open arm before/after self-admin	0.5	0.6	2.2	1.5	1.2	0.2	-0.2	0.3	-0.0
Diff in mean of infusions in LGA sessions	0.8	1.5	2.6	-0.4	-0.3	-1.5	1.5	1.6	1.3
Delay discount exponential model param	0.1	0.2	0.3	0.4	0.4	0.4	-0.4	-0.1	0.6
Extinction: sum of active levers before priming	0.2	0.3	0.8	-0.9	-0.9	0.1	-0.1	-0.1	0.1
Active lever presses in extinction session 6	0.1	0.1	0.5	-0.1	0.1	-0.1	0.1	0.6	0.7
Bone: final force	3.2	5.2	11.0	3.3	3.3	1.9	-1.9	-1.0	-1.1
Bone: final moment	2.5	4.1	9.6	3.1	3.1	1.5	-1.5	-0.5	-0.7
Food consumed during 24 hour testing period	0.9	1.8	3.2	1.7	1.8	1.2	-1.2	-0.9	-1.0
Glucose	0.1	0.2	0.4	-0.2	-0.1	-0.6	0.6	0.5	0.1
Heart weight	0.1	0.1	0.3	0.5	0.3	-0.3	0.3	0.0	-0.1
Delay discount hyperbolic model param	0.1	0.1	0.3	0.1	-0.0	0.2	-0.2	-0.1	0.6
Intermittent access intake day 1-15 change	0.2	1.1	2.4	-1.0	-0.5	0.8	-0.8	-1.3	-1.5
Intermittent access intake escalation	0.2	0.9	2.1	-1.1	-0.6	0.5	-0.5	-1.0	-1.5
Intermittent access intake escalation 2	0.7	1.3	2.8	-1.1	-0.8	0.8	-0.8	-1.3	-1.7
Intermitt. access day 1 inactive lever presses	0.0	0.4	0.8	-0.6	-0.9	0.5	-0.5	-0.6	-0.7
Intermitt. access day 15 inactive lever presses	0.1	0.6	0.8	0.5	0.7	0.9	-0.9	-0.9	-0.7
Intermitt. access escalation Index	0.1	0.2	0.5	0.6	0.5	-0.0	0.0	0.1	0.7
Intermittent access day 1 total infusions	0.1	0.4	0.9	0.9	1.0	0.1	-0.1	0.5	0.8
Intermittent access day 15 total infusions	0.0	0.1	0.2	-0.2	0.2	0.3	-0.3	-0.3	-0.4
Intermittent access terminal intake (last 3 days)	0.0	0.1	0.3	0.2	0.5	0.3	-0.3	-0.0	-0.1
Intermittent access total infusions	0.4	0.5	1.8	1.0	1.3	0.3	-0.3	0.2	0.1
Intermittent access day 1 locomotion	0.2	0.3	0.6	0.5	0.5	-0.3	0.3	0.7	0.7
Intermittent access day 15 total locomotion	0.1	0.5	0.9	-0.4	-0.0	-0.8	0.8	0.9	0.8
Intermittent access total locomotion	0.4	0.5	1.1	0.4	0.6	-0.5	0.5	1.0	1.0
Intermittent access standard deviation	0.6	3.0	4.3	1.1	1.5	1.9	-1.9	-1.8	-2.1
Left kidney weight	0.7	5.7	13.4	3.6	3.7	1.8	-1.8	-0.8	-0.7
Right kidney weight	0.8	5.9	15.9	3.9	4.0	1.4	-1.4	-0.2	-0.2
Cocaine induced anxiety	0.1	0.2	0.6	-0.4	-0.3	0.4	-0.4	-0.7	-0.4
Post-drug Anxiety	0.6	0.7	1.2	-0.7	-0.5	-1.1	1.1	0.8	0.5
Baseline Anxiety	0.5	0.9	2.1	0.3	0.5	-1.1	1.1	1.4	0.7
Tail length	0.2	1.0	2.8	1.7	1.7	-0.1	0.1	0.8	0.2
Length with tail	0.1	0.6	1.6	0.5	0.5	-0.7	0.7	1.2	0.7
Length without tail	0.2	1.0	1.8	-1.3	-1.2	-1.1	1.1	0.8	0.2
Times rat made contact with spout	3.5	4.0	5.2	1.3	1.5	2.3	-2.3	-2.3	-2.1
Lifetime Intake	0.6	0.7	2.4	1.2	1.6	0.4	-0.4	0.2	0.2
Liver weight, left	0.5	0.9	3.5	-0.7	-0.9	-0.5	0.5	0.7	1.9
Liver weight, right	0.2	0.4	1.3	-0.5	-0.7	0.1	-0.1	0.1	1.1
Locomotor activity	0.1	0.1	0.4	0.1	-0.2	0.1	-0.1	0.3	0.6
Locomotor testing distance	0.0	0.1	0.3	0.5	0.1	0.0	-0.0	0.4	0.5
Locomotor testing rearing	0.2	0.7	1.8	-0.2	-0.7	-0.6	0.6	0.9	1.3
Locomotion in novel chamber	0.8	1.1	3.4	0.6	0.6	-0.6	0.6	1.3	1.8
Locomotion in novel chamber post-restriction	0.6	1.9	3.3	-0.5	-0.7	-1.5	1.5	1.8	1.8
Fecal boli incidents, locomotor time 1	0.2	0.4	1.1	-1.1	-0.6	0.0	-0.0	-0.0	1.0
Change in fecal boli incidents, locomotor task	1.7	1.8	3.7	1.0	0.7	-1.6	1.6	1.9	0.7
Time >=10cm from walls, locomotor time 1	0.4	0.5	1.1	0.7	1.0	0.7	-0.7	-0.7	-0.5
Bouts of movement, locomotor time 1	1.5	2.0	4.4	-2.1	-2.1	-1.0	1.0	0.4	0.9
Total resting periods, locomotor time 1	2.0	2.3	5.2	-2.3	-2.2	-1.1	1.1	0.5	0.9
Rest time, locomotor task time 1	0.4	0.6	1.8	-1.3	-1.2	-0.0	0.0	-0.6	-0.5
Distance moved, locomotor task time 1	0.2	0.7	2.2	1.5	1.1	-0.0	0.0	0.7	0.7
Vertical activity count, locomotor time 1	0.2	1.5	4.2	2.1	1.7	0.8	-0.8	-0.4	-0.8
Time >=10cm from walls, locomotor time 2	0.6	1.7	2.5	1.5	1.6	1.3	-1.3	-1.0	-0.9
Bouts of movement, locomotor time 2	0.3	1.0	2.0	0.2	0.4	1.4	-1.4	-1.1	0.6
Total resting periods, locomotor time 2	0.3	1.1	2.2	0.5	0.7	1.5	-1.5	-1.1	0.5
Rest time, locomotor task time 2	0.1	0.1	0.3	-0.1	0.4	-0.4	0.4	0.5	0.3
Distance moved, locomotor task time 2	1.1	1.5	2.4	0.9	0.4	1.3	-1.3	-1.4	-1.5
Vertical activity count, locomotor time 2	0.3	0.7	1.6	0.8	0.5	0.7	-0.7	-0.8	-1.3
Light reinforcement 1	0.3	1.2	2.6	-0.4	-0.5	-1.1	1.1	1.4	1.6
Light reinforcement 2	0.4	0.8	2.1	-0.1	-0.1	-0.9	0.9	1.2	1.4
Bone: marrow area	1.1	2.6	3.7	1.9	1.8	1.9	-1.9	-1.2	-0.3
Bone: maximum diameter	1.5	3.1	6.2	2.5	2.3	1.8	-1.8	-0.8	-0.4
Bone: maximum force	2.5	5.0	10.0	3.2	3.1	2.0	-2.0	-1.0	-1.2
Bone: maximum moment	1.9	3.7	8.4	2.9	2.9	1.5	-1.5	-0.5	-0.7
Mean time between licks in bursts	0.0	0.2	0.4	-0.6	-0.6	-0.0	0.0	-0.5	0.2
Mean num. licks in bursts	1.4	3.8	10.3	3.2	3.2	1.1	-1.1	-0.3	-0.2
Cd content in liver	5.4	6.1	10.0	-1.0	-1.0	-2.7	2.7	3.2	3.1
Co content in liver	0.4	0.4	0.8	0.2	0.0	-0.9	0.9	0.9	-0.4
Cu content in liver	0.5	0.6	1.4	1.2	1.2	0.1	-0.1	0.8	0.5
Fe content in liver	0.2	0.3	0.7	-0.4	-0.4	-0.6	0.6	0.8	0.0
K content in liver	0.1	0.1	0.3	0.5	0.5	0.3	-0.3	0.1	0.4
Mg content in liver	0.2	0.2	0.5	0.2	0.2	0.7	-0.7	-0.2	0.6
Mn content in liver	0.5	0.6	0.9	0.8	0.7	1.0	-1.0	-0.7	-0.3
Na content in liver	4.6	5.2	6.8	2.3	2.3	2.6	-2.6	-2.3	-1.2
Rb content in liver	6.9	8.1	14.0	-1.2	-1.3	-3.5	3.5	3.7	2.7
Se content in liver	0.6	0.7	1.0	0.4	0.7	1.0	-1.0	-1.0	-0.8
Sr content in liver	0.7	0.6	0.9	0.9	0.8	0.9	-0.9	-0.6	-0.3
Zn content in liver	1.0	1.2	2.6	1.6	1.3	1.0	-1.0	-0.2	0.9
Bone: minimum diameter	1.6	3.1	4.7	2.2	2.0	2.1	-2.1	-1.2	-0.6
Time in familiar zone, hab. session 1	0.7	0.7	1.5	-0.5	-0.5	-1.2	1.2	0.9	-0.1
Time in novel zone, hab. session 1	0.4	0.5	0.9	0.6	0.6	0.9	-0.9	-0.6	0.2
Total zone transitions, hab. session 1	1.3	1.8	5.8	2.2	2.4	-0.1	0.1	0.3	-0.3
Total locomotion distance, hab. session 1	2.6	3.6	11.0	3.3	3.2	-0.0	0.0	0.7	0.3
Locomotion velocity, hab. session 1	2.2	3.1	8.8	3.0	2.9	-0.2	0.2	0.9	0.7
Time in familiar zone, hab. session 2	0.1	0.2	0.6	0.7	0.6	-0.1	0.1	-0.1	-0.2
Time in novel zone, hab. session 2	0.1	0.1	0.3	-0.3	-0.1	-0.2	0.2	0.4	0.6
Total zone transitions, hab. session 2	1.1	1.4	4.5	1.9	2.1	-0.1	0.1	0.5	0.1
Total locomotion distance, hab. session 2	1.5	2.0	5.8	2.4	2.4	-0.1	0.1	0.4	-0.2
Locomotion velocity, hab. session 2	1.7	2.3	6.9	2.6	2.6	0.2	-0.2	0.2	-0.2
Novel to familiar place preference ratio	0.3	0.4	1.1	-0.8	-1.0	-0.4	0.4	0.0	-0.5
Novelty place preference	0.3	0.4	1.0	-0.9	-1.0	-0.4	0.4	-0.1	-0.8
Time in novel zone, NPP test	0.3	0.4	0.9	-0.8	-0.9	-0.7	0.7	0.2	-0.4
Total zone transitions, NPP test	0.8	1.1	3.7	1.7	1.9	0.1	-0.1	0.1	-0.2
Total locomotion distance, NPP test	0.9	1.2	3.8	1.9	1.8	0.1	-0.1	-0.0	-0.5
Locomotion velocity, NPP test	0.7	1.1	3.1	1.8	1.7	0.1	-0.1	-0.1	-0.6
Intraocular pressure	0.1	0.1	0.3	0.5	0.3	0.4	-0.4	-0.2	0.1
Delta distance traveled before/after self-admin	0.5	0.6	0.8	0.7	0.9	0.9	-0.9	-0.6	-0.5
Delta ambulatory time before/after self-admin	0.7	1.3	1.5	1.1	1.1	1.2	-1.2	-1.0	-1.1
Parametrial fat weight	2.0	4.7	9.2	2.5	3.0	-1.1	1.1	2.3	2.3
Pavlov. Cond. lever latency	1.4	1.8	4.0	-0.3	-0.3	-2.0	2.0	1.7	-0.3
Pavlov. Cond. magazine entry latency	2.6	3.3	6.0	1.7	1.5	2.4	-2.4	-1.6	0.5
Pavlov. Cond. change in total contacts	3.6	3.9	7.9	0.6	0.2	2.8	-2.8	-2.6	-0.9
Pavlov. Cond. index score	2.0	2.5	5.4	0.8	0.7	2.3	-2.3	-1.7	0.4
Pavlov. Cond. latency score	1.7	2.1	4.5	0.8	0.7	2.1	-2.1	-1.5	0.5
Pavlov. Cond. lever contacts	2.1	2.6	5.4	0.9	0.9	2.3	-2.3	-1.7	0.3
Pavlov. Cond. magazine entry number	2.2	2.8	5.6	-1.0	-0.8	-2.4	2.4	1.9	0.1
Pavlov. Cond. intertrial magazine entries	2.3	2.7	4.8	-1.0	-1.1	-2.2	2.2	2.0	0.8
Pavlov. Cond. lever-magazine prob. diff.	2.3	2.9	6.0	1.0	0.9	2.5	-2.5	-1.8	0.4
Pavlov. Cond. response bias	3.0	3.7	7.7	0.9	0.8	2.8	-2.8	-2.3	-0.2
Pavlov. Cond. lever latency	0.5	0.6	1.7	-1.2	-1.3	0.1	-0.1	-0.4	-0.7
Pavlov. Cond. magazine entry latency	0.5	0.6	1.5	-1.2	-1.2	0.4	-0.4	-0.7	-0.1
Pavlov. Cond. change in total contacts	0.9	2.1	3.9	0.1	-0.0	-1.6	1.6	2.0	1.8
Pavlov. Cond. index score	0.1	0.1	0.5	-0.1	-0.1	-0.2	0.2	0.3	0.7
Pavlov. Cond. latency score	0.0	0.0	0.2	-0.0	-0.0	0.1	-0.1	0.0	0.4
Pavlov. Cond. lever contacts	0.4	0.6	1.4	1.1	1.2	0.0	-0.0	0.4	0.8
Pavlov. Cond. magazine entry number	0.9	1.2	3.1	1.7	1.8	0.7	-0.6	-0.3	-0.5
Pavlov. Cond. intertrial magazine entries	0.9	1.9	4.5	2.1	2.1	1.1	-1.1	-0.2	0.4
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.1	0.4	-0.3	-0.3	-0.1	0.1	0.2	0.6
Pavlov. Cond. response bias	0.2	0.3	1.0	0.2	0.2	-0.4	0.4	0.5	1.0
Time in closed arm before self-admin	0.0	0.1	0.2	0.3	0.5	-0.2	0.2	-0.0	0.1
Time in closed arm after self-admin	0.2	0.2	0.3	-0.3	-0.4	-0.5	0.5	0.4	-0.1
Time in open arm before self-admin	0.5	0.6	1.8	-1.2	-1.3	-0.3	0.3	0.1	0.3
Time in open arm after self-admin	2.2	2.4	3.2	1.5	1.2	1.8	-1.8	-1.6	-1.4
Bone: periosteal estimation	2.3	5.4	9.7	3.1	3.0	2.4	-2.4	-1.4	-0.9
Bone: periosteal perimeter	1.2	2.3	4.1	2.0	1.9	1.6	-1.6	-0.8	0.0
Bone: post-yield work	1.1	1.8	4.4	2.1	1.9	0.5	-0.5	0.7	1.4
Progressive ratio test 1 active lever presses	0.1	0.2	0.4	0.5	0.7	0.5	-0.5	-0.1	0.5
Progressive ratio test 1 breakpoint	0.1	0.2	0.4	0.4	0.6	0.5	-0.5	-0.1	0.5
Progressive ratio test 1 inactive lever presses	0.0	0.1	0.2	0.0	-0.0	0.4	-0.4	-0.4	0.2
Progressive ratio test 2 active lever presses	0.1	0.1	0.5	-0.1	0.0	-0.1	0.1	0.3	0.7
Progressive ratio test 2 breakpoint	0.1	0.2	0.7	-0.2	-0.1	-0.2	0.2	0.4	0.8
Progressive ratio test 2 inactive lever presses	0.1	0.2	0.2	0.5	0.5	0.4	-0.4	-0.0	0.4
Incentive Sensitization - Responses	0.0	0.0	0.1	-0.2	-0.2	0.1	-0.1	0.0	0.3
Incentive Sensitization - Breakpoint	0.0	0.1	0.2	-0.2	-0.1	-0.1	0.1	0.2	0.5
Sum of active levers in priming session hrs 5-6	1.3	1.2	3.7	-1.0	-1.0	-0.6	0.6	0.8	1.9
Progressive ratio	0.4	1.1	1.9	0.3	0.2	-1.4	1.4	1.4	1.0
Food seeking constrained by brief footshock	0.6	0.7	1.4	-1.2	-1.2	-0.7	0.7	0.5	-0.1
Seeking ratio, punishment vs. effort	0.6	1.2	2.4	-0.1	-0.0	1.6	-1.6	-1.3	-0.9
Retroperitoneal fat weight	1.8	8.0	16.5	2.3	2.1	-2.0	2.0	3.7	4.1
Reaction time number correct	0.2	0.7	1.2	-1.1	-1.1	-0.6	0.6	0.6	0.9
Reaction time mean minus median	0.0	0.1	0.2	0.4	0.4	0.1	-0.1	-0.2	-0.1
Reaction time mean minus median AUC	0.1	0.6	0.9	-0.3	-0.0	-0.9	0.9	1.0	1.0
Reaction time num false alarms	0.5	0.9	2.0	-0.8	-1.3	0.4	-0.4	-0.9	-1.4
Reaction time num false alarms AUC	0.3	0.7	1.3	-0.6	-1.1	0.6	-0.6	-0.9	-1.0
Reaction time trials correct on left	0.2	0.7	1.2	-1.1	-1.1	-0.6	0.6	0.6	0.9
Reaction time trials on left	0.2	0.7	1.2	-1.1	-1.1	-0.6	0.6	0.7	0.9
Reaction time mean	0.1	0.1	0.3	0.5	0.3	0.1	-0.1	0.2	0.5
Reaction time mean AUC	0.0	0.1	0.4	0.2	0.0	0.1	-0.1	0.2	0.6
Median of all reaction times	0.1	0.2	0.5	0.5	0.3	0.2	-0.2	0.2	0.7
Reaction time omissions	0.2	0.3	1.1	-0.6	-0.5	-0.2	0.2	0.3	1.0
Reaction time false alarm rate	0.8	1.1	2.6	-0.1	-0.5	1.0	-1.0	-1.4	-1.6
Reaction time premature initiation rate	1.2	1.9	2.4	1.5	1.1	1.3	-1.3	-1.4	-1.5
Reaction time premature initiations	0.3	0.8	1.1	0.7	0.3	1.0	-1.0	-1.0	-1.0
Std. dev. reaction times	0.0	0.2	0.3	0.5	0.5	-0.2	0.2	0.4	0.5
Reaction time trials completed	0.2	0.7	1.2	-1.1	-1.1	-0.6	0.6	0.7	0.9
Reaction time trials AUC	0.2	0.5	0.8	-0.9	-0.9	-0.5	0.5	0.7	0.9
Run reversals in cocaine runway, females	4.8	5.3	6.6	2.4	2.6	2.3	-2.3	-1.9	-2.3
Run reversals in cocaine runway, males	0.3	0.3	0.8	-0.8	-0.9	-0.2	0.2	-0.1	-0.5
Latency to leave start box in cocaine runway	1.1	1.5	2.9	-0.1	-0.1	-1.4	1.4	1.7	1.5
Latency to leave start box in cocaine runway, F	0.4	0.5	1.5	-0.3	-0.4	-0.5	0.5	0.8	1.2
Latency to leave start box in cocaine runway, M	1.6	1.6	3.0	0.1	0.2	-1.6	1.6	1.7	1.0
Std. dev. time between licks in bursts	0.1	0.2	0.6	0.2	0.2	0.5	-0.5	-0.4	0.8
Total sessions with >9 infusions	2.2	2.8	7.6	2.6	2.8	1.0	-1.0	0.2	0.5
Short access day 1 total inactive lever presses	0.1	0.3	0.6	0.7	0.8	0.5	-0.5	-0.2	-0.2
Short access day 10 total inactive lever presses	0.1	0.9	2.4	-1.5	-1.4	0.0	-0.0	-0.7	-0.7
Short access day 1 total infusions	0.4	0.7	1.7	1.3	1.3	0.7	-0.7	-0.0	-0.0
Short access day 10 total infusions	0.9	1.5	4.3	1.7	2.1	1.0	-1.0	-0.2	0.2
Short access total infusions	1.3	1.9	5.3	2.1	2.3	0.8	-0.8	0.2	0.4
Short access day 1 locomotion	0.2	0.3	0.6	0.6	0.8	0.6	-0.6	-0.2	-0.4
Short access day 10 total locomotion	0.6	2.4	4.3	2.1	1.9	1.6	-1.6	-1.0	-0.4
Short access total locomotion	1.2	1.8	4.7	2.2	2.2	0.3	-0.3	0.8	0.7
One hour access (0.3 mA shock)	0.2	0.3	1.3	0.0	0.3	-0.3	0.3	0.5	1.1
Compulsive drug intake	0.4	0.6	1.3	0.1	-0.5	-0.9	0.9	0.9	1.1
One hour access (shock baseline)	0.0	0.0	0.1	-0.3	0.1	-0.0	0.0	0.1	0.2
Social response proportion	0.7	0.9	2.3	-0.3	-0.3	-0.7	0.7	1.3	1.5
Social responses	0.6	0.8	1.9	-1.1	-1.0	-0.3	0.3	0.7	1.4
Social time	0.9	1.4	1.8	-1.2	-1.1	-1.3	1.3	1.1	0.9
Soleus weight	1.3	4.0	10.5	3.2	3.2	1.0	-1.0	-0.2	-0.9
Bone: stiffness	2.0	3.7	6.9	2.6	2.4	1.6	-1.6	-1.2	-1.7
Tibialis anterior weight	4.0	13.8	31.5	5.6	5.6	2.7	-2.7	-1.5	-1.9
Time to tail flick, vehicle, before self-admin	0.1	0.2	0.3	0.5	0.3	0.4	-0.4	-0.2	-0.4
Time to tail flick, vehicle, after self-admin	0.9	1.8	4.6	-2.1	-1.7	-1.0	1.0	0.6	0.9
Time to tail flick, test, before self-admin	0.4	0.5	1.2	0.2	-0.2	0.6	-0.6	-1.1	-0.9
Time to tail flick, test, after self-admin	2.7	2.8	5.5	-0.5	-0.2	2.0	-2.0	-2.4	-1.7
Delta time to tail flick, vehicle, before/after SA	0.5	0.6	0.8	-0.7	-0.4	-0.8	0.8	0.8	0.9
Delta time to tail flick, test, before/after SA	0.5	0.6	1.2	0.2	0.7	1.1	-1.1	-0.7	-0.4
Tibia length	0.1	0.2	0.5	0.3	0.2	-0.4	0.4	0.7	0.3
Ambulatory time before self-admin	0.0	0.1	0.4	0.0	0.2	-0.2	0.2	0.1	-0.6
Ambulatory time after self-admin	1.7	2.7	4.1	1.5	1.6	1.6	-1.6	-1.4	-2.0
Bone: tissue strength	0.4	0.4	0.6	0.3	0.3	0.8	-0.8	-0.6	-0.7
Total heroin consumption	1.1	1.3	3.5	-0.8	-0.8	-0.9	0.9	1.1	1.9
Bone: trabecular number	0.4	0.7	2.1	1.3	1.5	0.3	-0.3	-0.2	-0.4
Bone: trabecular spacing	0.5	0.7	1.7	-1.3	-1.3	0.1	-0.2	-0.2	0.8
Bone: trabecular thickness	1.8	2.5	4.2	2.0	2.0	-1.0	1.0	2.0	0.9
Bone: trabecular tissue density	0.0	0.0	0.2	0.1	0.0	-0.1	0.1	-0.1	-0.5
Water consumed over 24 hours	1.7	3.3	6.2	-0.7	-0.5	1.9	-1.9	-2.4	-2.5
Number of responses in last shaping day	0.2	0.2	0.4	0.3	0.1	0.7	-0.7	-0.4	-0.3