Vps35l

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	gene expression	Vps35l	0.05	0.03	7.4e-05	0.02	0.01	0.01	0.01	4.2e-03	1.2e-02	2.6e-02	1.2e-02
2	Adipose	mRNA stability	Vps35l	0.07	0.04	5.0e-05	0.02	0.01	0.01	0.01	9.6e-04	1.0e-02	1.9e-02	1.2e-02
3	NAcc	gene expression	Vps35l	0.08	0.05	1.6e-06	0.04	0.04	0.04	0.03	1.3e-05	1.4e-05	2.8e-05	6.7e-05
4	Brain	gene expression	Vps35l	0.06	0.04	4.8e-04	0.04	0.03	0.03	0.03	1.4e-04	5.7e-04	3.6e-04	4.3e-04
5	PL	gene expression	Vps35l	0.07	0.05	1.2e-04	0.03	0.03	0.03	0.03	1.4e-04	1.7e-04	5.6e-04	4.2e-04
6	BLA	gene expression	Vps35l	0.11	0.08	1.6e-03	0.03	0.03	-0	0.04	1.6e-02	6.9e-03	5.1e-01	2.4e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6
Bone: apparent density	0.4	0.8	1.9	1.4	1.3	0.8	0.1	0.3	-0.3
Area under the delay curve	0.2	0.2	0.3	-0.5	-0.4	0.3	-0.5	-0.5	0.5
BMI with tail	1.6	5.1	10.4	3.2	3.1	1.1	1.9	1.7	-1.7
BMI without tail	4.2	8.6	18.6	4.3	4.3	1.4	2.2	2.1	-2.1
Body weight	1.3	5.5	11.5	3.4	3.3	1.8	1.5	1.5	-1.5
Weight adjusted by age	0.2	0.3	0.6	0.4	0.5	-0.8	0.5	0.4	-0.4
Bone surface	0.9	1.5	2.1	1.4	1.4	1.2	0.9	1.2	-1.2
Bone volume	1.2	2.0	3.6	1.9	1.8	1.4	0.8	1.0	-1.0
Breakpoint value in progressive ratio session	2.9	3.2	4.8	-1.3	-1.4	-2.2	-1.9	-1.9	1.9
Number of licking bursts	2.2	2.6	7.8	-2.8	-2.7	-0.3	-0.0	-0.2	0.2
Context. condit. distance diff. score	0.4	0.5	0.9	-0.8	-0.7	-1.0	-0.3	-0.6	0.6
Locomotion velocity, session 1	0.2	0.2	0.6	0.1	0.4	0.8	0.3	0.3	-0.3
Locomotion distance, session 1	0.4	0.5	1.6	1.2	1.3	0.1	-0.1	0.0	-0.0
Locomotion velocity, session 2	0.0	0.1	0.2	-0.2	-0.0	0.5	-0.1	-0.1	0.1
Locomotion distance, session 2	1.3	1.8	3.6	1.8	1.9	1.3	0.7	0.9	-0.9
Locomotion velocity, session 3	0.2	0.2	0.7	0.7	0.8	0.3	0.3	0.2	-0.2
Locomotion distance, session 3	1.2	1.3	2.3	0.4	0.5	1.0	1.4	1.5	-1.5
Stereotopy head waving bouts, day 3	0.9	1.1	1.4	-0.8	-0.8	-1.1	-1.2	-1.2	1.2
Stereotopy head waving duration, day 3	0.9	1.1	1.6	-0.5	-0.6	-1.1	-1.2	-1.3	1.3
Locomotion velocity, session 7	2.3	2.5	3.7	1.1	1.3	1.3	1.9	1.8	-1.8
Locomotion distance, session 7	1.0	1.2	2.1	0.1	-0.2	1.1	1.4	1.5	-1.5
Stereotopy head waving bouts, day 7	0.2	0.2	0.4	0.5	0.6	-0.1	-0.4	-0.5	0.5
Stereotopy head waving duration, day 7	0.7	0.8	2.6	1.4	1.6	0.2	0.4	0.3	-0.3
Locomotion velocity, session 8	0.0	0.0	0.1	0.1	0.3	0.2	-0.2	-0.2	0.2
Locomotion distance, session 8	0.1	0.2	0.4	0.5	0.7	0.2	0.3	0.3	-0.3
Degree of sensitization distance	1.0	1.0	1.7	-0.2	-0.6	-0.6	-1.2	-1.3	1.3
Degree of sensitization stereotypy	0.9	0.9	2.2	1.3	1.5	0.8	0.6	0.5	-0.5
Conditioned locomotion	0.4	0.5	0.7	-0.8	-0.7	-0.2	0.8	0.8	-0.8
Cocaine response after cond. corrected	0.1	0.1	0.3	-0.5	-0.5	-0.1	-0.0	-0.1	0.1
Cocaine response after cond. not corrected	0.2	0.2	0.4	0.3	0.2	0.4	0.6	0.5	-0.5
Cocaine response before conditioning	2.2	2.7	3.1	1.8	1.7	1.5	1.7	1.5	-1.5
Saline control response	0.3	0.4	0.6	-0.3	-0.6	-0.8	-0.7	-0.7	0.7
Bone: connectivity density	0.3	0.4	0.8	0.9	0.9	0.3	0.3	0.5	-0.5
Bone: cortical apparent density	0.3	0.4	1.2	-0.9	-1.1	-0.1	-0.1	-0.3	0.3
Bone: cortical area	2.5	3.7	7.0	2.6	2.5	2.0	1.1	1.4	-1.4
Bone: cortical porosity	0.3	0.3	0.9	0.9	0.9	-0.3	0.1	0.1	-0.1
Bone: cortical porosity	0.2	0.2	0.8	0.4	0.4	-0.9	-0.2	-0.3	0.3
Bone: cortical thickness	1.1	1.9	3.7	1.9	1.8	1.9	0.2	0.6	-0.6
Bone: cortical thickness	0.5	0.6	2.0	0.8	0.7	1.4	-0.5	-0.3	0.3
Bone: cortical tissue density	0.3	0.4	1.2	-0.9	-1.1	-0.2	-0.1	-0.3	0.3
Condit. Reinf. active minus inactive responses	0.4	0.4	1.1	-0.4	-0.4	-1.1	-0.4	-0.6	0.6
Condit. Reinf. active-inactive response ratio	0.2	0.2	1.1	-0.2	-0.1	-1.0	0.1	-0.2	0.2
Condit. Reinf. active responses	0.2	0.3	0.6	-0.3	-0.4	-0.8	-0.5	-0.6	0.6
Condit. Reinf. inactive responses	0.1	0.1	0.2	-0.0	-0.2	0.0	-0.5	-0.3	0.3
Incentive salience index mean	0.1	0.2	0.5	0.1	0.0	-0.3	0.7	0.5	-0.5
Condit. Reinf. lever presses	0.5	0.6	1.4	-0.3	-0.3	-0.1	1.2	1.0	-1.0
Condit. Reinf. active minus inactive responses	0.8	0.9	1.5	0.6	0.7	-1.2	-1.2	-0.9	0.9
Condit. Reinf. active-inactive response ratio	1.3	1.4	2.5	-0.0	0.1	-1.5	-1.6	-1.3	1.3
Condit. Reinf. active responses	0.3	0.4	0.6	0.6	0.8	-0.8	-0.6	-0.5	0.5
Condit. Reinf. inactive responses	1.2	1.4	2.0	1.0	1.2	1.0	1.4	1.3	-1.3
Condit. Reinf. lever presses	0.4	0.6	1.9	1.2	1.4	-0.2	-0.0	0.1	-0.1
Condit. Reinf. lever reinforcers received	0.3	0.5	1.3	0.2	0.4	-1.1	-0.8	-0.6	0.6
Conditioned reinforcement - actives	0.3	0.3	0.5	0.4	0.7	0.3	-0.7	-0.7	0.7
Conditioned reinforcement - inactives	0.2	0.3	0.5	-0.7	-0.4	0.1	-0.5	-0.5	0.5
Conditioned locomotion	0.1	0.1	0.2	-0.4	-0.2	-0.1	-0.3	-0.3	0.3
Patch foraging indifference point 0 sec	0.7	1.2	2.0	0.8	0.8	-0.8	-1.1	-1.4	1.4
Patch foraging indifference point AUC	0.5	0.6	1.3	1.1	1.0	1.0	0.4	0.2	-0.2
Delay disc. indifference point, 0s delay	1.7	1.8	4.9	0.9	0.9	2.2	1.2	1.2	-1.2
Delay disc. indifference point, 16s delay	4.9	5.0	6.1	-2.4	-2.5	-1.9	-2.2	-2.2	2.2
Delay disc. indifference point, 2s delay	3.8	4.2	6.2	2.4	2.4	2.5	1.6	1.6	-1.6
Delay disc. indifference point, 24s delay	2.6	2.5	5.1	-2.3	-2.1	-1.1	-1.2	-1.2	1.2
Delay disc. indifference point, 4s delay	0.3	0.3	1.2	0.2	0.3	1.1	-0.4	-0.4	0.4
Delay disc. indifference point, 8s delay	0.1	0.1	0.7	-0.1	0.0	0.8	0.1	0.1	-0.1
Indifference point function ln k	0.1	0.1	0.4	0.6	0.6	0.3	-0.0	0.2	-0.2
Indifference point function log k	0.1	0.1	0.4	0.6	0.6	0.3	-0.0	0.2	-0.2
Patch foraging total patch changes 0 sec	0.9	1.4	2.3	0.8	0.8	-0.9	-1.2	-1.5	1.5
Patch foraging total patch changes 12 sec	0.1	0.1	0.3	0.5	0.4	-0.2	0.2	-0.0	0.0
Patch foraging total patch changes 18 sec	0.2	0.2	0.5	0.0	-0.1	-0.1	-0.6	-0.7	0.7
Patch foraging total patch changes 24 sec	0.4	0.5	0.9	1.0	0.8	-0.1	-0.4	-0.7	0.7
Patch foraging total patch changes 6 sec	2.4	3.6	7.2	-0.2	-0.2	-1.2	-2.4	-2.7	2.7
Patch foraging time to switch 0 sec	1.0	1.6	4.2	-2.1	-1.8	-1.1	0.5	0.6	-0.6
Patch foraging water rate 0 sec	0.1	0.1	0.4	0.7	0.5	0.3	-0.0	0.1	-0.1
Patch foraging water rate 12 sec	0.7	1.1	2.1	1.4	1.3	0.1	-1.1	-1.0	1.0
Patch foraging water rate 18 sec	0.4	0.5	0.9	0.5	0.5	-0.5	-0.9	-0.8	0.8
Patch foraging water rate 24 sec	0.3	0.4	1.1	1.0	0.8	1.0	-0.3	0.1	-0.1
Patch foraging water rate 6 sec	0.2	0.3	0.6	0.3	0.2	0.4	-0.8	-0.8	0.8
Seeking ratio, delayed vs. immediate footshock	0.0	0.0	0.1	0.1	0.2	-0.3	0.1	-0.1	0.1
Distance traveled before self-admin	0.1	0.2	0.7	0.2	0.3	0.8	0.1	0.1	-0.1
Distance traveled after self-admin	2.4	2.7	4.7	1.4	1.5	2.2	1.6	1.5	-1.5
Extensor digitorum longus weight	4.7	18.4	20.3	4.5	4.5	4.5	4.2	4.0	-4.0
Bone: elastic displacement	1.1	1.2	2.2	-0.7	-0.5	-0.6	-1.5	-1.4	1.4
Bone: elastic work	0.2	0.2	0.7	0.7	0.8	0.5	-0.0	-0.0	0.0
Bone: endosteal estimation	1.5	3.3	4.1	1.9	1.8	1.3	2.0	1.9	-1.9
Bone: endosteal perimeter	1.6	3.2	4.7	1.4	1.2	1.5	2.2	2.1	-2.1
Epididymis fat weight	0.3	0.7	2.0	1.3	1.4	-0.3	-0.1	-0.1	0.1
Delta time in closed arm before/after self-admin	0.5	0.5	1.0	-0.4	-0.6	0.1	1.0	0.9	-0.9
Delta time in open arm before/after self-admin	1.1	1.1	3.4	1.8	1.5	0.9	0.2	0.2	-0.2
Diff in mean of infusions in LGA sessions	1.9	2.1	3.3	-0.6	-0.7	-1.5	-1.7	-1.8	1.8
Delay discount exponential model param	0.2	0.2	0.3	0.5	0.5	-0.1	0.5	0.5	-0.5
Extinction: sum of active levers before priming	0.2	0.2	0.5	-0.7	-0.7	-0.1	0.2	-0.0	0.0
Active lever presses in extinction session 6	0.6	0.6	1.1	-0.2	-0.2	-1.0	-0.7	-1.0	1.0
Bone: final force	4.3	6.9	12.1	3.5	3.4	2.5	1.9	1.9	-1.9
Bone: final moment	3.2	5.2	10.2	3.2	3.2	2.1	1.5	1.5	-1.5
Food consumed during 24 hour testing period	1.8	2.1	2.7	1.6	1.6	1.6	1.4	1.2	-1.2
Glucose	0.5	0.8	1.9	-0.0	0.2	-0.2	-1.4	-1.2	1.2
Heart weight	0.4	0.5	1.3	0.1	-0.1	-0.1	-1.1	-0.9	0.9
Delay discount hyperbolic model param	0.1	0.1	0.2	0.2	0.1	-0.5	0.3	0.3	-0.3
Intermittent access intake day 1-15 change	0.6	0.6	1.1	-1.1	-0.8	0.7	0.7	0.7	-0.7
Intermittent access intake escalation	0.4	0.4	0.9	-0.9	-0.6	0.6	0.6	0.6	-0.6
Intermittent access intake escalation 2	0.7	0.7	1.0	-1.0	-0.8	0.6	0.8	0.9	-0.9
Intermitt. access day 1 inactive lever presses	0.1	0.1	0.3	-0.2	-0.6	0.4	0.1	0.2	-0.2
Intermitt. access day 15 inactive lever presses	1.1	1.2	1.6	0.7	0.8	1.2	1.2	1.3	-1.3
Intermitt. access escalation Index	0.5	0.4	1.1	0.8	1.0	0.2	0.5	0.5	-0.5
Intermittent access day 1 total infusions	0.6	0.7	1.6	1.1	1.3	-0.5	-0.7	-0.7	0.7
Intermittent access day 15 total infusions	0.1	0.1	0.3	0.1	0.5	-0.1	-0.4	-0.4	0.4
Intermittent access terminal intake (last 3 days)	0.1	0.1	0.3	0.2	0.5	-0.2	-0.4	-0.4	0.4
Intermittent access total infusions	0.5	0.6	1.4	0.8	1.2	-0.3	-0.6	-0.6	0.6
Intermittent access day 1 locomotion	0.6	0.7	1.1	1.0	1.0	-0.5	-0.8	-0.7	0.7
Intermittent access day 15 total locomotion	2.8	3.0	4.6	-1.1	-0.7	-1.7	-2.1	-2.1	2.1
Intermittent access total locomotion	1.2	1.4	2.1	0.5	0.8	-1.2	-1.4	-1.4	1.4
Intermittent access standard deviation	0.4	0.4	1.0	0.3	0.5	1.0	0.7	0.7	-0.7
Left kidney weight	2.3	6.5	13.4	3.4	3.7	2.3	1.8	1.7	-1.7
Right kidney weight	2.6	7.4	14.0	3.6	3.7	2.6	2.1	1.8	-1.8
Cocaine induced anxiety	0.1	0.1	0.1	-0.3	-0.3	-0.3	-0.1	-0.3	0.3
Post-drug Anxiety	0.9	1.0	1.9	-0.4	-0.3	-0.6	-1.2	-1.4	1.4
Baseline Anxiety	0.3	0.3	0.7	0.7	0.9	0.7	-0.3	-0.1	0.1
Tail length	1.2	3.5	8.9	3.0	2.8	1.6	0.7	0.9	-0.9
Length with tail	0.3	1.0	2.0	1.4	1.3	1.3	0.3	0.4	-0.4
Length without tail	0.3	0.6	1.5	-1.2	-1.2	0.4	-0.4	-0.3	0.3
Times rat made contact with spout	3.6	4.2	6.0	1.3	1.3	2.3	2.5	2.3	-2.3
Lifetime Intake	0.7	0.8	2.5	1.3	1.6	-0.1	-0.5	-0.5	0.5
Liver weight, left	0.1	0.1	0.2	0.5	0.5	-0.4	-0.0	-0.0	0.0
Liver weight, right	0.5	0.8	1.5	0.6	0.5	-0.2	1.2	1.2	-1.2
Locomotor activity	0.0	0.1	0.3	0.1	-0.2	-0.5	0.2	-0.1	0.1
Locomotor testing distance	0.1	0.1	0.4	0.6	0.3	-0.3	-0.2	-0.3	0.3
Locomotor testing rearing	0.3	0.4	1.4	-0.1	-0.4	-1.2	-0.6	-0.6	0.6
Locomotion in novel chamber	0.3	0.4	0.9	0.8	0.9	-0.7	-0.3	-0.5	0.5
Locomotion in novel chamber post-restriction	1.5	1.8	2.8	-0.3	-0.6	-1.3	-1.7	-1.7	1.7
Fecal boli incidents, locomotor time 1	0.6	0.6	2.1	-1.1	-0.5	-1.4	-0.1	-0.1	0.1
Change in fecal boli incidents, locomotor task	1.7	1.6	2.9	0.8	0.5	0.0	-1.7	-1.7	1.7
Time >=10cm from walls, locomotor time 1	0.7	0.7	1.4	0.8	1.2	1.1	0.7	0.7	-0.7
Bouts of movement, locomotor time 1	2.1	2.3	4.2	-2.0	-1.9	-1.8	-1.0	-1.0	1.0
Total resting periods, locomotor time 1	2.5	2.7	5.1	-2.3	-2.1	-1.8	-1.0	-1.0	1.0
Rest time, locomotor task time 1	0.4	0.4	1.4	-1.2	-1.0	0.3	0.2	0.2	-0.2
Distance moved, locomotor task time 1	0.7	0.8	3.1	1.7	1.3	0.2	-0.0	-0.0	0.0
Vertical activity count, locomotor time 1	2.1	2.2	5.2	2.3	1.9	1.6	0.8	0.8	-0.8
Time >=10cm from walls, locomotor time 2	2.3	2.5	3.4	1.7	1.8	1.7	1.4	1.4	-1.4
Bouts of movement, locomotor time 2	0.9	1.0	1.9	0.1	0.4	-0.3	1.4	1.4	-1.4
Total resting periods, locomotor time 2	1.0	1.1	2.0	0.4	0.7	-0.2	1.4	1.4	-1.4
Rest time, locomotor task time 2	0.1	0.1	0.2	-0.1	0.3	-0.2	-0.5	-0.5	0.5
Distance moved, locomotor task time 2	1.5	1.7	2.5	1.0	0.6	1.6	1.4	1.4	-1.4
Vertical activity count, locomotor time 2	1.0	1.1	2.4	1.1	0.7	1.6	0.8	0.8	-0.8
Light reinforcement 1	0.7	1.2	2.4	-0.5	-0.4	-1.6	-1.2	-1.2	1.2
Light reinforcement 2	0.5	0.7	1.3	-0.0	0.1	-1.1	-1.1	-1.0	1.0
Bone: marrow area	1.4	3.0	3.9	1.8	1.7	1.2	2.0	1.8	-1.8
Bone: maximum diameter	1.6	2.9	5.0	2.2	2.0	1.5	1.4	1.4	-1.4
Bone: maximum force	3.5	6.1	10.2	3.2	3.2	2.5	1.9	1.8	-1.8
Bone: maximum moment	2.6	4.4	8.4	2.9	2.9	2.0	1.5	1.3	-1.3
Mean time between licks in bursts	0.2	0.3	0.5	-0.4	-0.4	-0.4	0.4	0.7	-0.7
Mean num. licks in bursts	4.2	5.1	10.9	3.3	3.3	1.8	1.4	1.4	-1.4
Cd content in liver	6.1	6.7	7.6	-2.5	-2.5	-2.7	-2.2	-2.8	2.8
Co content in liver	1.5	1.7	3.0	-0.6	-0.7	-0.7	-1.7	-1.7	1.7
Cu content in liver	0.4	0.5	0.7	0.7	0.5	-0.1	-0.8	-0.8	0.8
Fe content in liver	0.6	0.8	1.7	-0.9	-0.8	-0.0	-1.3	-0.9	0.9
K content in liver	0.0	0.0	0.1	0.2	0.1	-0.3	-0.0	-0.0	0.0
Mg content in liver	0.4	0.4	1.9	-0.4	-0.6	-1.4	-0.4	-0.1	0.1
Mn content in liver	0.6	0.7	1.4	0.4	0.4	0.6	1.2	1.0	-1.0
Na content in liver	6.1	6.4	8.0	2.3	2.3	2.2	2.6	2.8	-2.8
Rb content in liver	3.7	4.6	8.9	-0.8	-0.9	-2.1	-3.0	-2.5	2.5
Se content in liver	0.4	0.5	0.7	0.3	0.4	0.8	0.9	0.8	-0.8
Sr content in liver	0.5	0.4	0.7	0.8	0.7	0.5	0.6	0.6	-0.6
Zn content in liver	1.7	1.9	3.8	1.9	1.7	0.7	1.1	1.3	-1.3
Bone: minimum diameter	1.7	3.2	4.1	2.0	2.0	1.6	1.6	1.7	-1.7
Time in familiar zone, hab. session 1	0.9	0.9	1.6	-0.5	-0.4	-0.1	-1.2	-1.3	1.3
Time in novel zone, hab. session 1	0.6	0.6	1.2	0.5	0.5	-0.1	0.8	1.1	-1.1
Total zone transitions, hab. session 1	1.5	2.1	5.7	2.2	2.4	1.5	0.1	0.2	-0.2
Total locomotion distance, hab. session 1	2.8	3.9	10.9	3.3	3.2	1.4	-0.0	0.2	-0.2
Locomotion velocity, hab. session 1	2.1	3.0	8.8	3.0	2.9	0.9	-0.1	0.0	-0.0
Time in familiar zone, hab. session 2	0.2	0.2	0.5	0.7	0.6	0.6	0.2	0.2	-0.2
Time in novel zone, hab. session 2	0.1	0.1	0.4	-0.3	-0.2	-0.6	-0.4	-0.3	0.3
Total zone transitions, hab. session 2	1.1	1.4	4.2	1.9	2.1	0.8	0.1	0.0	-0.0
Total locomotion distance, hab. session 2	1.7	2.2	5.8	2.4	2.4	1.3	0.1	0.2	-0.2
Locomotion velocity, hab. session 2	2.0	2.7	6.8	2.6	2.6	1.5	0.4	0.5	-0.5
Novel to familiar place preference ratio	0.4	0.4	0.9	-0.8	-0.9	-0.2	-0.5	-0.5	0.5
Novelty place preference	0.4	0.4	0.8	-0.8	-0.9	0.1	-0.5	-0.4	0.4
Time in novel zone, NPP test	0.4	0.5	0.7	-0.8	-0.8	-0.2	-0.8	-0.6	0.6
Total zone transitions, NPP test	0.9	1.3	3.4	1.8	1.8	1.0	0.3	0.3	-0.3
Total locomotion distance, NPP test	1.1	1.5	3.7	1.9	1.8	1.3	0.1	0.4	-0.4
Locomotion velocity, NPP test	0.9	1.3	3.1	1.8	1.6	1.3	0.1	0.4	-0.4
Intraocular pressure	0.1	0.1	0.3	0.6	0.4	-0.1	-0.1	0.3	-0.3
Delta distance traveled before/after self-admin	1.1	1.1	1.5	1.2	1.2	0.9	1.1	1.0	-1.0
Delta ambulatory time before/after self-admin	1.0	1.1	1.2	1.1	1.1	1.1	1.0	0.9	-0.9
Parametrial fat weight	1.2	2.3	7.4	2.3	2.7	0.8	0.2	0.1	-0.1
Pavlov. Cond. lever latency	1.8	2.2	4.5	-0.6	-0.5	0.2	-2.1	-2.0	2.0
Pavlov. Cond. magazine entry latency	2.3	2.9	4.8	1.6	1.3	0.0	2.0	2.2	-2.2
Pavlov. Cond. change in total contacts	3.9	4.2	8.3	0.6	0.3	0.6	2.9	2.8	-2.8
Pavlov. Cond. index score	2.2	2.8	5.3	0.9	0.6	-0.3	2.3	2.3	-2.3
Pavlov. Cond. latency score	1.9	2.4	4.3	0.9	0.7	-0.3	2.1	2.1	-2.1
Pavlov. Cond. lever contacts	2.9	3.4	6.9	0.9	0.7	0.1	2.6	2.5	-2.5
Pavlov. Cond. magazine entry number	2.5	3.2	6.2	-0.9	-0.6	-0.2	-2.3	-2.5	2.5
Pavlov. Cond. intertrial magazine entries	2.3	2.7	4.8	-1.0	-0.9	-0.9	-2.0	-2.2	2.2
Pavlov. Cond. lever-magazine prob. diff.	2.7	3.3	6.0	1.1	0.9	-0.2	2.4	2.5	-2.5
Pavlov. Cond. response bias	3.4	4.1	7.9	0.8	0.6	0.3	2.8	2.8	-2.8
Pavlov. Cond. lever latency	0.3	0.5	1.3	-1.1	-1.2	-0.2	0.1	-0.2	0.2
Pavlov. Cond. magazine entry latency	0.8	0.9	2.1	-1.4	-1.4	-0.6	0.7	0.5	-0.5
Pavlov. Cond. change in total contacts	1.1	1.5	2.6	-0.1	-0.1	-1.3	-1.5	-1.6	1.6
Pavlov. Cond. index score	0.1	0.1	0.3	-0.3	-0.3	-0.6	-0.1	-0.1	0.1
Pavlov. Cond. latency score	0.0	0.0	0.1	-0.2	-0.2	-0.3	0.2	0.1	-0.1
Pavlov. Cond. lever contacts	0.3	0.5	1.3	1.1	1.1	0.0	0.1	0.3	-0.3
Pavlov. Cond. magazine entry number	1.3	1.6	3.3	1.8	1.8	1.3	0.7	0.7	-0.7
Pavlov. Cond. intertrial magazine entries	1.3	1.7	4.1	2.0	2.0	0.6	0.7	0.8	-0.8
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.2	0.4	-0.5	-0.5	-0.7	0.0	-0.0	0.0
Pavlov. Cond. response bias	0.0	0.1	0.3	0.1	0.1	-0.6	-0.1	-0.1	0.1
Time in closed arm before self-admin	0.4	0.4	1.3	1.0	1.1	0.5	-0.1	0.1	-0.1
Time in closed arm after self-admin	1.5	1.5	2.2	-0.8	-0.9	-1.0	-1.5	-1.5	1.5
Time in open arm before self-admin	1.2	1.3	3.0	-1.7	-1.7	-1.2	-0.4	-0.5	0.5
Time in open arm after self-admin	2.2	2.4	2.9	1.4	1.1	1.7	1.7	1.7	-1.7
Bone: periosteal estimation	2.6	5.3	8.0	2.8	2.7	2.1	2.0	2.1	-2.1
Bone: periosteal perimeter	1.2	2.1	3.0	1.7	1.7	1.0	1.3	1.4	-1.4
Bone: post-yield work	0.8	1.1	3.3	1.8	1.6	-0.1	0.5	0.2	-0.2
Progressive ratio test 1 active lever presses	0.2	0.3	0.4	0.5	0.7	-0.5	-0.5	-0.4	0.4
Progressive ratio test 1 breakpoint	0.2	0.2	0.4	0.5	0.6	-0.5	-0.5	-0.4	0.4
Progressive ratio test 1 inactive lever presses	0.1	0.1	0.5	0.7	0.6	0.2	0.1	0.0	-0.0
Progressive ratio test 2 active lever presses	0.4	0.4	0.6	0.4	0.5	-0.7	-0.8	-0.8	0.8
Progressive ratio test 2 breakpoint	0.5	0.5	0.8	0.3	0.4	-0.8	-0.9	-0.8	0.8
Progressive ratio test 2 inactive lever presses	0.4	0.5	0.8	0.1	0.1	-0.9	-0.8	-0.8	0.8
Incentive Sensitization - Responses	0.2	0.2	0.5	-0.0	0.0	-0.7	-0.4	-0.4	0.4
Incentive Sensitization - Breakpoint	0.2	0.2	0.5	0.0	0.1	-0.7	-0.5	-0.4	0.4
Sum of active levers in priming session hrs 5-6	0.4	0.4	1.5	-0.0	-0.2	-1.2	-0.4	-0.5	0.5
Progressive ratio	1.1	1.3	2.6	-0.1	-0.1	-0.6	-1.5	-1.6	1.6
Food seeking constrained by brief footshock	0.9	1.1	2.4	-1.3	-1.5	-0.6	-0.6	-0.9	0.9
Seeking ratio, punishment vs. effort	0.7	0.8	1.8	-0.0	-0.1	0.3	1.3	1.2	-1.2
Retroperitoneal fat weight	0.7	2.3	4.1	0.7	0.6	-1.6	-2.0	-1.8	1.8
Reaction time number correct	0.7	1.0	1.7	-1.2	-1.3	-1.3	-0.6	-0.7	0.7
Reaction time mean minus median	0.1	0.1	0.2	0.4	0.4	0.3	0.2	0.2	-0.2
Reaction time mean minus median AUC	0.4	0.5	0.9	-0.2	-0.0	-0.8	-0.8	-0.9	0.9
Reaction time num false alarms	0.4	0.5	1.3	-0.8	-1.1	0.7	0.5	0.3	-0.3
Reaction time num false alarms AUC	0.3	0.4	1.1	-0.7	-1.1	0.4	0.6	0.4	-0.4
Reaction time trials correct on left	0.7	1.0	1.7	-1.2	-1.3	-1.3	-0.6	-0.7	0.7
Reaction time trials on left	0.7	1.1	1.8	-1.2	-1.3	-1.3	-0.6	-0.8	0.8
Reaction time mean	0.1	0.2	0.5	0.7	0.7	-0.1	0.0	-0.0	0.0
Reaction time mean AUC	0.1	0.1	0.2	0.4	0.4	-0.4	0.0	-0.0	0.0
Median of all reaction times	0.1	0.2	0.5	0.7	0.6	-0.2	0.1	0.0	-0.0
Reaction time omissions	0.3	0.4	1.3	-0.7	-0.7	-1.1	0.1	0.1	-0.1
Reaction time false alarm rate	0.5	0.8	1.5	-0.1	-0.3	1.2	1.1	1.0	-1.0
Reaction time premature initiation rate	1.9	2.5	3.3	1.5	1.3	1.8	1.6	1.7	-1.7
Reaction time premature initiations	0.7	1.0	1.5	0.6	0.4	1.0	1.2	1.2	-1.2
Std. dev. reaction times	0.1	0.1	0.4	0.6	0.6	-0.1	-0.2	-0.2	0.2
Reaction time trials completed	0.7	1.1	1.8	-1.2	-1.3	-1.3	-0.6	-0.8	0.8
Reaction time trials AUC	0.6	0.8	1.4	-1.0	-1.1	-1.2	-0.6	-0.7	0.7
Run reversals in cocaine runway, females	6.4	6.2	8.5	2.7	2.7	2.9	2.4	2.1	-2.1
Run reversals in cocaine runway, males	0.2	0.2	0.5	-0.6	-0.7	-0.2	-0.1	-0.1	0.1
Latency to leave start box in cocaine runway	1.4	1.6	2.5	-0.4	-0.2	-1.4	-1.5	-1.6	1.6
Latency to leave start box in cocaine runway, F	0.6	0.7	2.2	-0.6	-0.5	-1.5	-0.5	-0.6	0.6
Latency to leave start box in cocaine runway, M	1.8	1.7	3.4	-0.1	0.1	-0.5	-1.8	-1.8	1.8
Std. dev. time between licks in bursts	0.2	0.2	0.4	0.1	0.1	-0.6	0.3	0.6	-0.6
Total sessions with >9 infusions	2.7	3.0	6.7	2.3	2.6	1.6	1.0	1.1	-1.1
Short access day 1 total inactive lever presses	0.2	0.2	0.5	0.1	0.0	-0.1	-0.7	-0.7	0.7
Short access day 10 total inactive lever presses	0.3	0.4	1.1	-0.9	-1.0	-0.0	-0.3	-0.2	0.2
Short access day 1 total infusions	0.5	0.6	1.5	1.2	1.2	0.1	-0.4	-0.4	0.4
Short access day 10 total infusions	0.9	0.9	2.6	1.3	1.6	0.7	0.5	0.6	-0.6
Short access total infusions	1.1	1.2	3.8	1.7	2.0	0.1	-0.4	-0.3	0.3
Short access day 1 locomotion	0.1	0.1	0.2	0.4	0.5	0.2	-0.3	-0.2	0.2
Short access day 10 total locomotion	0.7	0.8	2.2	1.5	1.4	0.4	0.3	0.4	-0.4
Short access total locomotion	1.3	1.3	2.3	1.4	1.5	-0.6	-1.1	-1.0	1.0
One hour access (0.3 mA shock)	0.8	0.9	2.8	1.5	1.7	-0.3	-0.2	-0.3	0.3
Compulsive drug intake	0.3	0.4	0.6	0.5	-0.1	-0.8	-0.6	-0.7	0.7
One hour access (shock baseline)	0.1	0.2	0.3	-0.3	0.1	-0.4	-0.5	-0.4	0.4
Social response proportion	1.0	1.1	2.2	-0.5	-0.4	-1.5	-1.1	-1.2	1.2
Social responses	0.8	1.1	2.5	-1.1	-1.2	-1.6	-0.4	-0.8	0.8
Social time	1.4	1.9	2.0	-1.4	-1.4	-1.4	-1.4	-1.3	1.3
Soleus weight	1.4	4.0	8.5	2.9	2.8	2.3	1.0	0.8	-0.8
Bone: stiffness	3.4	5.3	7.6	2.8	2.7	2.7	1.9	1.7	-1.7
Tibialis anterior weight	4.8	16.6	29.1	5.4	5.4	4.2	2.9	2.8	-2.8
Time to tail flick, vehicle, before self-admin	0.4	0.4	0.7	0.6	0.4	0.7	0.8	0.7	-0.7
Time to tail flick, vehicle, after self-admin	1.0	1.1	2.1	-1.4	-1.0	-1.3	-0.6	-0.8	0.8
Time to tail flick, test, before self-admin	0.7	0.6	1.2	0.2	-0.1	1.1	0.8	1.0	-1.0
Time to tail flick, test, after self-admin	1.0	1.1	1.7	-1.2	-0.8	0.2	1.3	1.1	-1.1
Delta time to tail flick, vehicle, before/after SA	0.6	0.6	1.4	-0.6	-0.3	-1.2	-0.7	-0.8	0.8
Delta time to tail flick, test, before/after SA	0.2	0.2	0.4	-0.5	0.0	-0.4	0.6	0.3	-0.3
Tibia length	0.1	0.3	0.7	0.0	-0.1	-0.0	-0.8	-0.8	0.8
Ambulatory time before self-admin	0.2	0.2	0.6	0.0	0.2	0.8	-0.3	-0.3	0.3
Ambulatory time after self-admin	2.5	2.7	5.5	1.6	1.5	2.3	1.5	1.4	-1.4
Bone: tissue strength	0.1	0.1	0.2	0.1	0.2	0.5	0.5	0.4	-0.4
Total heroin consumption	1.7	2.0	4.5	-1.0	-0.7	-2.1	-1.4	-1.5	1.5
Bone: trabecular number	0.3	0.5	1.2	1.1	1.1	0.9	0.0	0.3	-0.3
Bone: trabecular spacing	0.6	0.8	1.8	-1.1	-1.2	-1.3	0.2	0.2	-0.2
Bone: trabecular thickness	1.6	2.0	3.7	1.9	1.9	0.6	-1.1	-1.2	1.2
Bone: trabecular tissue density	0.0	0.1	0.2	0.2	0.2	0.5	0.2	-0.0	0.0
Water consumed over 24 hours	1.7	2.0	3.6	-0.9	-0.9	1.2	1.9	1.6	-1.6
Number of responses in last shaping day	0.2	0.3	0.8	0.9	0.7	0.4	0.3	0.3	-0.3