Hub : Genes

Tmem151a

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	gene expression	Tmem151a	0.2	0.1	1.7e-13	0.08	0.09	0.09	0.1	1.8e-09	2.0e-10	4.2e-10	1.1e-10
2	Brain	gene expression	Tmem151a	0.04	0.03	1.6e-03	0.02	0.01	0.02	0.01	5.2e-03	3.3e-02	6.5e-03	1.8e-02
3	pVTA	mRNA stability	Tmem151a	0.2	0.11	8.0e-06	0.12	0.07	0.06	0.1	5.3e-06	7.3e-04	1.0e-03	4.9e-05
4	BLA	mRNA stability	Tmem151a	0.21	0.1	7.5e-09	0.14	0.16	0.12	0.14	8.8e-08	1.2e-08	8.5e-07	4.6e-08
5	PL	mRNA stability	Tmem151a	0.26	0.1	0.0e+00	0.2	0.21	0.2	0.21	1.4e-21	1.7e-22	1.6e-21	1.2e-22
6	Brain	mRNA stability	Tmem151a	0.46	0.14	0.0e+00	0.36	0.25	0.36	0.37	4.1e-35	1.9e-23	2.7e-35	5.0e-36
7	NAcc	mRNA stability	Tmem151a	0.27	0.12	0.0e+00	0.21	0.22	0.21	0.21	2.3e-23	1.2e-24	4.8e-24	4.6e-24

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Bone: apparent density	3.2	5.4	7.4	-0.7	-1.6	-2.7	2.6	2.7	2.7	2.6
Area under the delay curve	1.0	1.1	1.6	0.8	-0.8	-0.9	1.0	1.2	1.3	1.3
BMI with tail	4.3	13.8	19.4	-2.2	-0.9	-4.3	4.3	4.4	4.3	4.0
BMI without tail	1.8	3.7	5.7	-1.0	-0.3	-2.3	2.2	2.4	2.3	2.1
Body weight	1.4	5.7	14.9	-3.9	2.1	-2.3	1.9	2.2	2.1	1.5
Weight adjusted by age	0.8	0.9	4.4	-2.1	1.3	-0.1	-0.0	0.3	0.1	-0.2
Bone surface	3.6	6.4	8.5	-2.9	-0.4	-2.9	2.7	2.7	2.8	2.3
Bone volume	2.7	4.6	6.0	-1.7	-1.1	-2.4	2.5	2.4	2.4	2.2
Breakpoint value in progressive ratio session	1.0	1.1	5.4	-2.3	1.1	-0.7	0.4	0.5	0.4	0.1
Number of licking bursts	0.1	0.1	0.5	-0.7	0.1	-0.3	0.3	0.2	0.3	0.2
Context. condit. distance diff. score	0.6	0.7	3.4	1.8	-1.0	0.4	-0.2	-0.2	-0.4	0.0
Locomotion velocity, session 1	0.3	0.3	0.6	0.4	0.8	0.4	-0.6	-0.5	-0.6	-0.6
Locomotion distance, session 1	1.7	2.2	3.5	-0.3	-0.3	-1.7	1.6	1.8	1.9	1.7
Locomotion velocity, session 2	1.1	1.3	3.0	-1.7	0.9	-1.1	1.0	1.1	1.0	0.8
Locomotion distance, session 2	1.1	1.5	2.5	-0.7	0.3	-1.5	1.3	1.4	1.6	1.3
Locomotion velocity, session 3	0.5	0.6	0.8	0.5	-0.6	-0.8	0.8	0.8	0.8	0.9
Locomotion distance, session 3	0.0	0.0	0.0	0.2	-0.1	-0.1	0.0	0.0	0.1	0.0
Stereotopy head waving bouts, day 3	0.7	0.8	1.6	1.2	-1.0	-0.7	0.7	0.7	0.7	0.9
Stereotopy head waving duration, day 3	0.6	0.7	1.7	1.3	-1.3	-0.4	0.6	0.5	0.4	0.7
Locomotion velocity, session 7	1.1	1.2	1.7	0.5	-1.1	-0.9	1.2	1.2	1.3	1.3
Locomotion distance, session 7	0.3	0.4	0.7	0.2	-0.1	-0.6	0.6	0.8	0.8	0.8
Stereotopy head waving bouts, day 7	0.6	0.7	2.0	0.2	-1.4	-0.7	0.9	0.6	0.6	0.8
Stereotopy head waving duration, day 7	1.6	2.0	2.8	-1.2	-0.9	-1.7	1.6	1.4	1.4	1.5
Locomotion velocity, session 8	0.3	0.3	1.5	-0.9	1.2	-0.2	-0.2	-0.0	-0.1	-0.2
Locomotion distance, session 8	0.2	0.3	0.6	0.8	-0.5	-0.3	0.5	0.4	0.4	0.6
Degree of sensitization distance	0.6	0.6	1.1	0.1	-0.3	-0.8	0.8	1.0	0.9	0.9
Degree of sensitization stereotypy	0.6	0.6	1.1	-1.1	-0.7	-0.9	0.9	0.6	0.6	0.7
Conditioned locomotion	0.9	1.0	3.0	-1.6	1.7	0.5	-0.5	-0.5	-0.4	-0.6
Cocaine response after cond. corrected	0.3	0.4	2.0	1.4	-0.4	0.5	-0.4	-0.3	-0.3	-0.1
Cocaine response after cond. not corrected	0.3	0.3	1.7	1.3	-0.6	0.1	-0.1	-0.0	-0.1	0.1
Cocaine response before conditioning	0.3	0.3	1.0	-1.0	-0.1	-0.7	0.6	0.5	0.3	0.4
Saline control response	1.3	1.8	3.9	-2.0	1.2	-1.5	1.0	1.3	1.1	0.9
Bone: connectivity density	4.1	6.4	8.9	-1.8	-0.8	-2.9	2.7	2.9	3.0	2.6
Bone: cortical apparent density	0.1	0.2	0.5	-0.6	0.7	0.2	-0.3	-0.2	-0.2	-0.2
Bone: cortical area	0.4	0.6	2.3	-1.5	1.0	0.4	-0.4	-0.5	-0.4	-0.6
Bone: cortical porosity	0.9	1.0	1.4	-0.0	-0.5	-1.1	1.1	1.1	1.2	1.1
Bone: cortical porosity	0.8	0.9	1.4	-0.5	-0.1	-1.2	1.0	1.1	1.2	1.0
Bone: cortical thickness	2.0	3.4	8.7	-2.7	3.0	0.9	-1.3	-1.1	-1.1	-1.5
Bone: cortical thickness	1.3	1.5	4.0	-1.0	2.0	0.8	-1.2	-0.9	-1.1	-1.1
Bone: cortical tissue density	0.2	0.2	0.7	-0.6	0.8	0.2	-0.3	-0.2	-0.3	-0.3
Condit. Reinf. active minus inactive responses	0.2	0.3	0.5	-0.3	-0.0	-0.6	0.7	0.6	0.6	0.6
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.1	-0.1	-0.2	-0.3	0.4	0.2	0.3	0.3
Condit. Reinf. active responses	0.1	0.1	0.3	-0.3	0.0	-0.3	0.5	0.3	0.4	0.4
Condit. Reinf. inactive responses	0.0	0.0	0.1	-0.1	-0.2	-0.1	0.4	0.2	0.2	0.3
Incentive salience index mean	0.4	0.5	0.8	-0.5	-0.0	-0.7	0.9	0.7	0.8	0.8
Condit. Reinf. lever presses	0.1	0.1	0.6	-0.8	0.4	0.1	0.3	-0.1	0.0	0.0
Condit. Reinf. active minus inactive responses	0.5	0.6	1.6	0.3	-1.3	-0.7	0.8	0.6	0.8	0.7
Condit. Reinf. active-inactive response ratio	0.3	0.3	1.8	0.5	-1.3	0.0	0.4	-0.0	0.2	0.2
Condit. Reinf. active responses	1.5	2.0	2.7	-0.1	-1.3	-1.6	1.6	1.6	1.6	1.5
Condit. Reinf. inactive responses	2.1	2.6	4.3	-0.3	-0.7	-2.1	1.6	2.0	1.8	1.8
Condit. Reinf. lever presses	1.1	1.5	4.7	-2.2	0.2	-1.3	1.2	1.1	1.0	0.8
Condit. Reinf. lever reinforcers received	1.3	1.8	2.6	-0.5	-1.1	-1.6	1.5	1.5	1.5	1.4
Conditioned reinforcement - actives	0.2	0.2	0.4	0.1	-0.0	0.4	-0.5	-0.6	-0.6	-0.6
Conditioned reinforcement - inactives	1.7	1.9	4.4	2.1	-1.9	1.2	-0.8	-1.3	-1.1	-0.7
Conditioned locomotion	3.5	4.2	9.4	3.1	-1.4	2.1	-1.7	-2.2	-1.9	-1.6
Patch foraging indifference point 0 sec	0.1	0.2	0.5	0.2	-0.7	-0.3	0.4	0.3	0.3	0.3
Patch foraging indifference point AUC	1.0	1.2	5.8	-2.4	1.3	-0.6	0.2	0.3	0.2	0.0
Delay disc. indifference point, 0s delay	1.2	1.3	3.0	1.7	-0.9	-1.1	0.8	1.1	1.1	1.2
Delay disc. indifference point, 16s delay	0.7	0.7	2.2	0.8	-1.5	-0.2	0.8	0.5	0.7	0.7
Delay disc. indifference point, 2s delay	0.1	0.2	0.5	0.7	-0.5	-0.1	0.3	0.2	0.4	0.4
Delay disc. indifference point, 24s delay	0.1	0.1	0.2	0.4	0.5	0.3	-0.4	-0.1	-0.2	-0.2
Delay disc. indifference point, 4s delay	0.7	0.7	1.0	1.0	-0.5	-0.8	0.7	0.9	1.0	1.0
Delay disc. indifference point, 8s delay	0.6	0.6	0.9	0.7	-0.3	-0.8	0.6	0.9	0.9	1.0
Indifference point function ln k	2.7	3.8	16.8	4.1	-1.4	1.7	-1.1	-1.3	-1.2	-0.8
Indifference point function log k	2.7	3.8	16.8	4.1	-1.4	1.7	-1.1	-1.3	-1.2	-0.8
Patch foraging total patch changes 0 sec	0.0	0.0	0.0	0.2	-0.1	0.1	-0.1	-0.1	-0.2	-0.1
Patch foraging total patch changes 12 sec	1.8	2.3	7.3	-2.7	1.0	-1.5	1.1	1.4	1.2	0.9
Patch foraging total patch changes 18 sec	0.6	0.8	1.3	-1.1	-0.2	-1.0	0.8	0.9	0.9	0.8
Patch foraging total patch changes 24 sec	0.6	0.8	3.4	-1.8	1.3	-0.5	-0.0	0.3	0.2	-0.1
Patch foraging total patch changes 6 sec	0.8	1.2	1.9	-1.3	0.2	-1.4	1.1	1.2	1.1	1.0
Patch foraging time to switch 0 sec	2.6	4.0	5.3	-1.9	-0.4	-2.1	2.3	2.2	2.2	2.1
Patch foraging water rate 0 sec	3.9	6.2	8.5	2.6	-0.3	2.9	-2.6	-2.9	-2.7	-2.5
Patch foraging water rate 12 sec	5.2	8.0	16.9	4.1	-0.4	3.0	-2.9	-2.9	-2.7	-2.4
Patch foraging water rate 18 sec	1.5	2.0	6.2	2.5	-0.4	1.4	-1.3	-1.3	-1.2	-1.0
Patch foraging water rate 24 sec	3.3	4.6	7.1	2.7	-0.1	2.4	-2.2	-2.4	-2.2	-1.9
Patch foraging water rate 6 sec	3.0	4.4	7.4	2.7	0.3	2.4	-2.3	-2.2	-2.0	-1.9
Seeking ratio, delayed vs. immediate footshock	0.7	0.8	1.3	0.2	-0.7	-0.8	1.0	1.0	0.9	1.1
Distance traveled before self-admin	0.1	0.1	0.6	-0.8	0.3	-0.2	0.2	0.1	0.2	0.0
Distance traveled after self-admin	0.1	0.1	0.5	-0.7	0.1	-0.0	0.1	-0.1	0.1	-0.1
Extensor digitorum longus weight	2.1	8.4	34.5	-5.9	3.8	-1.8	1.2	1.6	1.3	0.7
Bone: elastic displacement	2.1	2.3	3.5	0.9	1.0	1.8	-1.9	-1.7	-1.5	-1.6
Bone: elastic work	0.9	1.2	3.6	-1.0	1.9	0.8	-1.1	-0.8	-0.6	-1.0
Bone: endosteal estimation	1.1	2.4	4.9	1.7	-2.2	-1.0	1.5	1.2	1.4	1.5
Bone: endosteal perimeter	1.6	3.3	8.1	1.7	-2.8	-1.3	1.8	1.4	1.7	1.7
Epididymis fat weight	0.8	1.8	7.1	2.7	-2.3	0.4	0.1	-0.3	-0.0	0.3
Delta time in closed arm before/after self-admin	0.1	0.1	0.5	0.1	0.7	-0.2	-0.3	0.2	0.0	-0.0
Delta time in open arm before/after self-admin	0.2	0.2	0.3	-0.5	-0.0	0.6	-0.2	-0.4	-0.4	-0.4
Diff in mean of infusions in LGA sessions	0.3	0.4	1.3	-1.1	0.7	0.3	-0.4	-0.4	-0.4	-0.6
Delay discount exponential model param	0.8	0.8	1.2	-0.6	0.6	0.8	-0.9	-1.0	-1.1	-1.1
Extinction: sum of active levers before priming	2.1	2.0	5.9	-2.4	0.8	-1.4	1.3	1.3	1.2	0.9
Active lever presses in extinction session 6	1.5	1.4	3.9	-2.0	1.6	0.7	-0.8	-0.8	-0.8	-1.1
Bone: final force	0.8	1.3	4.8	-2.2	1.1	-0.9	0.7	0.8	0.8	0.4
Bone: final moment	0.7	1.1	4.2	-2.0	1.0	-0.9	0.7	0.8	0.7	0.4
Food consumed during 24 hour testing period	0.4	0.5	0.7	-0.4	0.3	0.8	-0.7	-0.8	-0.8	-0.9
Glucose	1.7	2.5	5.7	1.9	-2.4	-1.0	1.3	1.1	1.3	1.5
Heart weight	0.9	1.2	5.3	2.3	-1.8	0.2	0.1	0.1	0.0	0.4
Delay discount hyperbolic model param	0.7	0.7	1.0	-0.6	0.5	0.8	-0.8	-1.0	-1.0	-1.0
Intermittent access intake day 1-15 change	1.1	1.1	1.7	0.1	0.1	1.3	-1.2	-1.2	-1.2	-1.3
Intermittent access intake escalation	0.5	0.5	0.7	0.2	-0.2	0.9	-0.8	-0.8	-0.8	-0.8
Intermittent access intake escalation 2	1.1	1.1	1.7	-0.1	0.4	1.1	-1.2	-1.3	-1.2	-1.3
Intermitt. access day 1 inactive lever presses	0.6	0.7	2.0	1.2	-1.4	0.7	-0.1	-0.7	-0.4	-0.1
Intermitt. access day 15 inactive lever presses	0.5	0.5	1.6	0.8	-1.3	0.7	-0.3	-0.6	-0.4	-0.3
Intermitt. access escalation Index	1.9	1.7	6.5	2.6	-1.8	-0.2	0.6	0.5	0.7	0.8
Intermittent access day 1 total infusions	4.1	4.8	11.5	2.5	-3.4	-1.6	1.9	1.5	1.6	2.1
Intermittent access day 15 total infusions	1.8	2.0	7.6	2.5	-2.8	0.1	0.2	-0.1	-0.0	0.4
Intermittent access terminal intake (last 3 days)	1.5	1.6	6.6	2.0	-2.6	-0.3	0.6	0.2	0.3	0.7
Intermittent access total infusions	2.5	2.7	8.0	1.9	-2.8	-1.2	1.3	1.1	1.1	1.5
Intermittent access day 1 locomotion	3.9	4.1	7.7	2.0	-2.8	-1.7	1.9	1.7	1.7	2.2
Intermittent access day 15 total locomotion	1.2	1.3	5.3	1.9	-2.3	-0.2	0.4	0.1	0.2	0.5
Intermittent access total locomotion	3.5	4.0	12.3	2.4	-3.5	-1.1	1.6	1.2	1.3	1.8
Intermittent access standard deviation	0.4	0.5	0.6	0.7	-0.3	0.7	-0.8	-0.7	-0.7	-0.7
Left kidney weight	0.5	1.4	2.8	1.1	-0.4	1.7	-1.0	-1.4	-1.1	-1.1
Right kidney weight	0.8	2.2	4.0	0.0	0.2	2.0	-1.4	-2.0	-1.6	-1.7
Cocaine induced anxiety	0.2	0.2	0.4	-0.3	0.3	0.4	-0.4	-0.6	-0.6	-0.5
Post-drug Anxiety	1.1	1.2	2.9	-1.7	1.4	0.8	-0.7	-0.9	-0.9	-0.9
Baseline Anxiety	0.8	0.8	2.9	-1.7	1.5	0.1	-0.3	-0.1	-0.1	-0.5
Tail length	1.2	3.8	8.1	-1.3	2.8	1.6	-2.0	-1.7	-1.8	-2.0
Length with tail	1.0	3.8	11.7	-3.2	3.4	0.6	-1.1	-0.8	-0.9	-1.3
Length without tail	0.7	1.6	6.6	-2.6	1.9	-0.7	0.2	0.4	0.4	-0.1
Times rat made contact with spout	0.6	0.6	1.0	-0.5	0.1	-0.9	0.8	1.0	0.9	0.9
Lifetime Intake	2.6	3.0	7.3	1.9	-2.7	-1.4	1.4	1.3	1.3	1.6
Liver weight, left	0.1	0.2	0.4	0.5	0.0	0.4	-0.4	-0.4	-0.6	-0.4
Liver weight, right	0.1	0.1	0.4	0.6	0.3	0.0	-0.3	-0.1	-0.2	-0.1
Locomotor activity	1.3	2.0	4.0	2.0	0.3	1.4	-1.7	-1.4	-1.3	-1.3
Locomotor testing distance	1.5	2.4	6.4	2.5	0.3	1.4	-1.8	-1.4	-1.3	-1.3
Locomotor testing rearing	0.6	0.9	5.2	2.3	-0.9	0.1	-0.5	-0.1	-0.1	0.0
Locomotion in novel chamber	1.4	1.7	4.8	2.2	-1.8	0.9	-0.7	-1.1	-0.9	-0.6
Locomotion in novel chamber post-restriction	0.9	1.0	4.2	2.0	-1.2	0.7	-0.5	-0.6	-0.6	-0.4
Fecal boli incidents, locomotor time 1	0.2	0.2	0.7	-0.8	-0.3	0.4	-0.1	-0.4	-0.3	-0.4
Change in fecal boli incidents, locomotor task	0.7	0.7	1.8	0.5	-0.1	-1.4	0.6	0.9	0.9	0.9
Time >=10cm from walls, locomotor time 1	2.0	2.0	4.5	0.5	-2.1	-1.3	1.6	1.2	1.2	1.5
Bouts of movement, locomotor time 1	0.4	0.4	2.5	-1.6	0.6	-0.0	0.1	0.1	0.1	-0.1
Total resting periods, locomotor time 1	0.3	0.3	2.0	-1.4	0.3	-0.2	0.3	0.2	0.2	0.1
Rest time, locomotor task time 1	1.2	1.3	2.4	1.2	-0.4	1.5	-1.0	-1.3	-1.1	-1.0
Distance moved, locomotor task time 1	1.2	1.3	2.4	-0.3	-0.6	-1.5	1.2	1.3	1.2	1.3
Vertical activity count, locomotor time 1	0.2	0.2	0.9	1.0	-0.7	0.1	-0.3	-0.2	-0.2	-0.1
Time >=10cm from walls, locomotor time 2	0.1	0.1	0.2	-0.0	-0.4	-0.4	0.2	0.0	0.1	0.1
Bouts of movement, locomotor time 2	0.2	0.3	1.0	-1.0	0.2	-0.5	0.3	0.4	0.4	0.3
Total resting periods, locomotor time 2	0.2	0.2	0.5	-0.7	-0.0	-0.5	0.5	0.4	0.5	0.5
Rest time, locomotor task time 2	0.7	0.8	3.1	1.8	-1.1	1.0	-0.4	-0.6	-0.4	-0.2
Distance moved, locomotor task time 2	0.3	0.4	1.4	-1.2	0.8	-0.6	0.1	0.1	0.1	-0.1
Vertical activity count, locomotor time 2	1.2	1.4	2.3	0.0	1.3	0.8	-1.5	-1.2	-1.3	-1.4
Light reinforcement 1	0.1	0.1	0.4	0.7	-0.1	0.3	-0.4	-0.3	-0.3	-0.3
Light reinforcement 2	0.7	1.0	1.8	0.7	-0.7	1.4	-0.7	-1.2	-1.1	-0.9
Bone: marrow area	1.1	2.5	5.0	1.8	-2.2	-1.1	1.5	1.2	1.4	1.5
Bone: maximum diameter	0.1	0.2	0.5	-0.7	0.1	0.3	-0.1	-0.4	-0.2	-0.4
Bone: maximum force	2.0	3.5	6.2	-2.5	0.2	-2.0	2.0	1.9	2.0	1.6
Bone: maximum moment	1.8	3.0	5.2	-2.3	0.2	-1.9	1.9	1.8	1.9	1.5
Mean time between licks in bursts	0.1	0.2	1.1	-0.0	1.0	-0.4	-0.1	0.2	0.2	-0.0
Mean num. licks in bursts	0.1	0.2	0.4	0.6	-0.4	-0.3	0.2	0.4	0.3	0.4
Cd content in liver	0.9	1.0	1.5	1.0	-0.5	1.2	-1.1	-1.2	-0.9	-1.1
Co content in liver	1.7	1.9	3.0	1.5	0.7	1.3	-1.7	-1.4	-1.5	-1.3
Cu content in liver	0.2	0.3	0.5	-0.7	-0.0	-0.6	0.6	0.6	0.4	0.5
Fe content in liver	0.1	0.1	0.3	-0.5	0.4	0.3	-0.3	-0.3	-0.4	-0.4
K content in liver	2.0	2.0	2.7	-1.3	-0.1	-1.6	1.6	1.6	1.4	1.5
Mg content in liver	4.1	4.2	5.8	-0.1	-1.5	-2.4	2.4	2.3	2.2	2.4
Mn content in liver	0.9	1.0	5.1	-2.3	0.7	-0.7	0.7	0.5	0.6	0.4
Na content in liver	0.7	0.7	1.4	-1.2	1.0	0.7	-0.6	-0.7	-0.8	-0.9
Rb content in liver	1.6	2.0	3.7	1.6	-1.9	-1.2	1.2	1.3	1.2	1.4
Se content in liver	0.7	0.8	1.4	-0.5	-1.2	-0.7	1.0	0.8	1.2	0.8
Sr content in liver	1.6	1.5	4.0	-2.0	1.7	0.6	-0.8	-0.8	-0.9	-1.0
Zn content in liver	0.5	0.6	1.8	-1.3	0.5	-0.6	0.6	0.6	0.7	0.5
Bone: minimum diameter	1.9	3.5	6.1	1.2	-2.5	-1.5	2.0	1.8	1.9	2.0
Time in familiar zone, hab. session 1	0.4	0.3	0.6	0.5	-0.8	-0.5	0.7	0.5	0.4	0.6
Time in novel zone, hab. session 1	0.5	0.5	0.9	0.7	0.5	0.7	-1.0	-0.7	-0.7	-0.7
Total zone transitions, hab. session 1	0.3	0.5	0.9	-0.9	0.7	-0.7	0.6	0.7	0.7	0.5
Total locomotion distance, hab. session 1	0.1	0.2	0.6	0.8	-0.5	0.1	0.3	0.2	0.2	0.3
Locomotion velocity, hab. session 1	0.1	0.1	0.1	0.2	-0.1	-0.1	0.4	0.3	0.4	0.3
Time in familiar zone, hab. session 2	0.3	0.3	0.7	0.2	0.9	0.3	-0.7	-0.4	-0.5	-0.5
Time in novel zone, hab. session 2	0.7	0.7	1.1	-0.2	-0.8	-0.8	1.1	0.9	0.9	1.0
Total zone transitions, hab. session 2	5.2	6.7	9.7	-0.7	-1.0	-3.1	2.9	3.1	3.1	2.9
Total locomotion distance, hab. session 2	1.9	2.5	3.5	0.6	-1.2	-1.7	1.7	1.8	1.9	1.8
Locomotion velocity, hab. session 2	1.7	2.3	3.2	0.6	-1.3	-1.5	1.7	1.7	1.8	1.7
Novel to familiar place preference ratio	0.6	0.6	1.8	-1.4	-0.4	-0.6	0.9	0.7	0.6	0.6
Novelty place preference	0.5	0.5	0.8	-0.9	-0.7	-0.6	0.9	0.6	0.5	0.6
Time in novel zone, NPP test	0.4	0.4	0.7	-0.7	-0.7	-0.6	0.9	0.6	0.5	0.6
Total zone transitions, NPP test	1.3	1.9	2.6	-1.4	0.5	-1.6	1.5	1.5	1.6	1.3
Total locomotion distance, NPP test	0.3	0.4	0.8	0.2	-0.2	-0.6	0.8	0.8	0.9	0.7
Locomotion velocity, NPP test	0.2	0.3	0.6	0.0	-0.1	-0.5	0.7	0.6	0.8	0.6
Intraocular pressure	1.4	1.9	3.3	0.2	-0.2	1.8	-1.4	-1.7	-1.6	-1.5
Delta distance traveled before/after self-admin	0.0	0.0	0.0	0.0	0.1	0.1	-0.2	-0.1	-0.1	-0.2
Delta ambulatory time before/after self-admin	0.0	0.0	0.1	0.0	0.2	0.1	-0.2	-0.1	-0.1	-0.2
Parametrial fat weight	1.0	2.0	6.8	2.1	-2.6	-0.2	0.9	0.5	0.8	1.0
Pavlov. Cond. lever latency	0.1	0.1	0.2	0.5	-0.1	0.5	-0.5	-0.3	-0.3	-0.3
Pavlov. Cond. magazine entry latency	1.0	1.3	2.0	-0.2	-1.0	-1.2	1.4	1.1	1.2	1.3
Pavlov. Cond. change in total contacts	0.2	0.2	0.5	-0.4	-0.7	-0.3	0.7	0.2	0.3	0.4
Pavlov. Cond. index score	0.0	0.0	0.1	-0.4	-0.1	-0.1	0.3	-0.1	-0.1	0.0
Pavlov. Cond. latency score	0.0	0.1	0.2	-0.2	-0.2	-0.3	0.4	0.1	0.2	0.3
Pavlov. Cond. lever contacts	0.0	0.0	0.0	-0.0	0.0	-0.1	0.2	-0.0	0.0	0.1
Pavlov. Cond. magazine entry number	0.1	0.1	0.5	0.7	-0.1	-0.1	-0.0	0.4	0.4	0.3
Pavlov. Cond. intertrial magazine entries	0.4	0.4	0.6	0.3	-0.0	0.8	-0.7	-0.8	-0.7	-0.8
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.1	0.3	-0.6	-0.0	-0.3	0.4	0.0	0.1	0.2
Pavlov. Cond. response bias	0.1	0.1	0.2	-0.4	0.0	0.1	0.0	-0.3	-0.3	-0.2
Pavlov. Cond. lever latency	0.2	0.3	1.6	1.3	-0.1	0.3	-0.5	-0.3	-0.3	-0.2
Pavlov. Cond. magazine entry latency	2.1	2.5	5.0	-2.2	0.5	-1.7	1.5	1.7	1.5	1.3
Pavlov. Cond. change in total contacts	1.2	1.7	4.8	-2.2	-0.3	-1.2	1.4	1.1	1.2	0.9
Pavlov. Cond. index score	1.2	1.5	4.9	-2.2	0.3	-1.1	1.2	1.1	1.0	0.8
Pavlov. Cond. latency score	0.9	1.2	4.1	-2.0	0.3	-0.9	1.1	0.9	0.9	0.7
Pavlov. Cond. lever contacts	0.2	0.3	1.5	-1.2	0.4	0.1	-0.0	-0.1	-0.2	-0.3
Pavlov. Cond. magazine entry number	3.0	3.6	9.7	3.1	-0.8	2.0	-1.7	-1.9	-1.7	-1.3
Pavlov. Cond. intertrial magazine entries	0.4	0.6	1.7	1.3	-0.7	0.7	-0.6	-0.7	-0.6	-0.4
Pavlov. Cond. lever-magazine prob. diff.	1.4	1.8	5.7	-2.4	0.4	-1.2	1.3	1.2	1.1	0.9
Pavlov. Cond. response bias	0.7	0.9	3.8	-2.0	0.4	-0.8	0.8	0.8	0.7	0.5
Time in closed arm before self-admin	0.1	0.1	0.2	-0.2	-0.3	-0.1	0.4	0.2	0.3	0.3
Time in closed arm after self-admin	0.0	0.0	0.0	0.1	0.1	-0.1	0.2	0.1	0.2	0.2
Time in open arm before self-admin	0.2	0.2	1.3	1.1	0.1	-0.1	-0.2	0.2	0.0	0.2
Time in open arm after self-admin	0.4	0.4	0.7	0.4	0.2	0.8	-0.8	-0.6	-0.8	-0.6
Bone: periosteal estimation	0.1	0.1	0.4	-0.1	-0.6	-0.2	0.5	0.2	0.4	0.3
Bone: periosteal perimeter	0.3	0.5	0.8	-0.4	-0.7	-0.7	0.9	0.7	0.9	0.7
Bone: post-yield work	7.8	10.7	16.5	-0.6	-2.9	-3.3	4.1	3.4	3.6	3.7
Progressive ratio test 1 active lever presses	0.6	0.7	2.4	1.6	-1.5	-0.1	0.1	0.1	0.0	0.3
Progressive ratio test 1 breakpoint	0.5	0.5	2.1	1.4	-1.2	0.0	-0.1	-0.1	-0.2	0.1
Progressive ratio test 1 inactive lever presses	0.5	0.5	1.5	1.2	-1.2	-0.3	0.3	0.2	0.3	0.5
Progressive ratio test 2 active lever presses	0.9	1.0	3.9	1.7	-2.0	-0.2	0.2	-0.0	0.0	0.3
Progressive ratio test 2 breakpoint	1.0	1.2	4.1	2.0	-1.8	0.4	-0.4	-0.6	-0.5	-0.2
Progressive ratio test 2 inactive lever presses	2.3	2.7	9.8	2.9	-3.1	0.0	0.4	-0.1	0.1	0.6
Incentive Sensitization - Responses	0.3	0.3	0.9	0.2	-0.9	-0.7	0.4	0.3	0.4	0.4
Incentive Sensitization - Breakpoint	0.2	0.2	1.0	0.4	-1.0	-0.5	0.3	0.2	0.2	0.2
Sum of active levers in priming session hrs 5-6	3.1	3.0	4.2	-2.0	1.5	1.6	-1.5	-1.7	-1.7	-2.0
Progressive ratio	3.8	4.4	6.4	-1.2	-0.7	-2.3	2.4	2.5	2.4	2.3
Food seeking constrained by brief footshock	0.1	0.1	0.5	-0.4	0.7	0.0	-0.2	0.0	0.0	-0.1
Seeking ratio, punishment vs. effort	2.4	2.9	4.2	1.4	0.7	1.9	-2.0	-2.0	-1.8	-1.8
Retroperitoneal fat weight	1.5	4.9	20.2	4.5	-3.5	1.0	-0.1	-0.6	-0.3	0.2
Reaction time number correct	0.5	0.8	1.4	-0.7	1.2	0.8	-0.9	-0.9	-0.7	-1.0
Reaction time mean minus median	1.1	1.4	7.1	-2.7	0.8	-0.8	0.7	0.7	0.6	0.4
Reaction time mean minus median AUC	0.7	0.9	4.4	-2.1	1.2	0.1	-0.2	-0.1	-0.2	-0.4
Reaction time num false alarms	0.7	0.9	1.2	0.9	1.0	1.0	-1.1	-0.9	-0.9	-0.9
Reaction time num false alarms AUC	0.5	0.7	1.9	0.1	1.4	0.7	-0.9	-0.6	-0.7	-0.7
Reaction time trials correct on left	0.5	0.8	1.4	-0.7	1.2	0.8	-0.9	-0.9	-0.7	-1.0
Reaction time trials on left	0.7	1.0	1.7	-0.9	1.3	0.9	-1.0	-1.0	-0.7	-1.1
Reaction time mean	0.0	0.0	0.2	-0.4	-0.1	-0.0	0.1	0.0	-0.1	0.0
Reaction time mean AUC	0.0	0.0	0.1	-0.4	-0.3	-0.1	0.2	0.1	-0.1	0.1
Median of all reaction times	0.0	0.0	0.2	0.2	-0.4	-0.1	0.1	0.1	-0.1	0.1
Reaction time omissions	0.5	0.7	3.4	-1.8	1.2	-0.1	-0.0	0.1	-0.0	-0.1
Reaction time false alarm rate	0.2	0.3	0.5	0.7	0.6	0.5	-0.6	-0.3	-0.5	-0.4
Reaction time premature initiation rate	0.6	0.8	3.6	-1.2	1.9	-0.5	-0.2	0.2	-0.1	-0.2
Reaction time premature initiations	1.3	1.8	7.3	-1.9	2.7	0.0	-0.7	-0.3	-0.5	-0.8
Std. dev. reaction times	0.3	0.4	2.5	-1.6	0.4	-0.3	0.2	0.2	0.1	0.1
Reaction time trials completed	0.7	1.0	1.7	-0.9	1.3	0.9	-1.0	-1.0	-0.7	-1.1
Reaction time trials AUC	0.5	0.7	1.3	-0.6	1.1	0.7	-0.9	-0.8	-0.6	-0.9
Run reversals in cocaine runway, females	2.1	2.0	4.1	-0.1	-0.1	-2.0	1.5	1.7	1.5	1.6
Run reversals in cocaine runway, males	3.3	3.2	4.5	0.1	1.4	1.8	-2.1	-2.1	-2.1	-2.0
Latency to leave start box in cocaine runway	0.9	0.9	1.5	0.1	-0.9	-0.9	1.2	1.0	1.1	1.1
Latency to leave start box in cocaine runway, F	0.6	0.7	1.3	0.1	-0.6	-1.2	0.9	0.9	0.8	0.9
Latency to leave start box in cocaine runway, M	0.0	0.0	0.1	-0.2	-0.2	0.2	0.3	0.0	0.2	0.1
Std. dev. time between licks in bursts	0.6	0.7	1.1	0.6	1.0	0.7	-1.0	-0.7	-0.8	-0.8
Total sessions with >9 infusions	1.1	1.2	2.3	1.4	-1.5	-0.9	0.9	0.9	0.8	1.1
Short access day 1 total inactive lever presses	1.2	1.3	5.4	2.3	-1.9	0.1	0.2	-0.1	0.1	0.3
Short access day 10 total inactive lever presses	1.0	1.1	4.0	2.0	-0.9	1.0	-0.6	-0.9	-0.7	-0.3
Short access day 1 total infusions	2.8	2.9	6.6	2.0	-2.6	-1.2	1.5	1.3	1.4	1.7
Short access day 10 total infusions	5.5	6.1	7.6	1.2	-2.7	-2.6	2.6	2.5	2.5	2.7
Short access total infusions	2.5	2.8	3.9	1.4	-2.0	-1.7	1.6	1.7	1.6	1.8
Short access day 1 locomotion	2.5	2.6	5.3	1.5	-2.3	-1.4	1.5	1.4	1.4	1.7
Short access day 10 total locomotion	2.4	2.6	4.7	1.3	-2.2	-1.4	1.6	1.5	1.5	1.7
Short access total locomotion	2.4	2.5	3.8	1.3	-1.9	-1.5	1.6	1.5	1.4	1.7
One hour access (0.3 mA shock)	2.1	2.5	9.6	3.1	-2.6	0.3	-0.3	-0.6	-0.5	0.0
Compulsive drug intake	0.9	0.9	4.5	-1.2	2.1	-0.2	-0.5	0.0	-0.1	-0.3
One hour access (shock baseline)	2.0	2.3	8.7	2.6	-2.9	0.5	-0.2	-0.7	-0.6	-0.1
Social response proportion	0.7	0.7	1.1	-1.0	-0.1	-1.0	0.9	0.9	0.9	0.8
Social responses	0.1	0.1	0.5	-0.7	0.5	-0.3	-0.1	0.2	0.1	0.0
Social time	0.1	0.2	0.7	-0.5	0.8	-0.2	-0.2	0.0	-0.1	-0.1
Soleus weight	1.5	4.4	13.9	3.7	-1.6	2.3	-1.4	-1.8	-1.5	-1.2
Bone: stiffness	2.1	3.3	4.5	-2.1	-0.3	-2.1	2.1	1.9	1.9	1.7
Tibialis anterior weight	3.2	10.9	45.9	-6.8	5.4	-0.3	-0.6	-0.2	-0.5	-1.2
Time to tail flick, vehicle, before self-admin	0.6	0.6	1.0	-0.6	-0.1	-1.0	0.9	0.9	0.8	0.8
Time to tail flick, vehicle, after self-admin	1.3	1.4	2.3	-0.9	0.6	-1.4	1.1	1.5	1.2	1.3
Time to tail flick, test, before self-admin	1.8	1.8	2.4	1.2	-1.2	-1.2	1.2	1.5	1.4	1.6
Time to tail flick, test, after self-admin	0.1	0.1	0.2	-0.2	0.1	0.4	-0.2	-0.2	-0.3	-0.2
Delta time to tail flick, vehicle, before/after SA	0.5	0.5	1.0	-0.6	0.3	-0.8	0.7	1.0	0.8	0.8
Delta time to tail flick, test, before/after SA	3.2	2.9	3.3	-1.5	1.8	1.6	-1.6	-1.8	-1.8	-1.8
Tibia length	0.7	1.9	5.7	-2.4	1.5	1.0	-0.8	-1.2	-0.9	-1.3
Ambulatory time before self-admin	0.1	0.1	0.9	-1.0	-0.1	-0.1	0.3	-0.0	0.1	0.1
Ambulatory time after self-admin	0.4	0.4	1.2	-0.2	-1.1	-0.2	0.8	0.3	0.6	0.6
Bone: tissue strength	0.2	0.2	0.3	-0.2	-0.4	-0.4	0.6	0.4	0.6	0.4
Total heroin consumption	1.4	1.7	7.4	-2.7	1.6	-0.7	0.5	0.7	0.7	0.2
Bone: trabecular number	2.7	4.2	5.5	-1.1	-1.4	-2.3	2.3	2.3	2.3	2.2
Bone: trabecular spacing	0.4	0.6	0.7	0.9	0.4	0.8	-0.8	-0.8	-0.8	-0.7
Bone: trabecular thickness	1.6	1.9	2.6	0.6	-1.6	-1.3	1.4	1.5	1.5	1.5
Bone: trabecular tissue density	1.9	2.6	4.9	2.2	-0.9	2.0	-1.4	-1.8	-1.3	-1.4
Water consumed over 24 hours	0.3	0.3	0.9	-0.9	0.4	-0.7	0.3	0.6	0.5	0.4
Number of responses in last shaping day	0.4	0.5	1.5	1.2	-0.2	0.8	-0.6	-0.6	-0.6	-0.4