Hub : Genes

Krt75

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 NAcc gene expression Krt75 0.05 0.04 3.5e-09 0.05 0.06 0.05 0.06 1.3e-08 6.2e-10 2.0e-08 2.6e-09
2 Eye intron excision ratio chr7_134573721_134573960 0.29 0.2 8.9e-03 0.09 0.06 0.03 0.06 1.6e-02 3.8e-02 1.2e-01 4.0e-02
3 BLA gene expression Krt75 0.11 0.1 3.6e-03 0.06 0.05 0.02 0.05 6.8e-04 1.0e-03 4.4e-02 8.6e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bone: apparent density0.20.30.60.3-0.40.8
Area under the delay curve0.00.00.10.4-0.00.1
BMI with tail1.75.96.72.4-2.62.3
BMI without tail0.42.22.71.4-1.61.4
Body weight0.52.12.71.1-1.61.5
Weight adjusted by age0.61.62.10.8-1.51.5
Bone surface0.20.50.60.7-0.60.8
Bone volume0.51.01.50.9-0.81.2
Breakpoint value in progressive ratio session0.00.10.20.40.00.0
Number of licking bursts0.00.10.30.3-0.50.1
Context. condit. distance diff. score0.00.00.00.00.00.0
Locomotion velocity, session 12.73.15.2-2.31.5-1.4
Locomotion distance, session 10.40.50.9-1.00.3-0.7
Locomotion velocity, session 22.02.44.1-2.01.3-1.2
Locomotion distance, session 20.50.81.4-1.20.6-0.7
Locomotion velocity, session 33.84.46.5-2.51.9-1.7
Locomotion distance, session 34.14.75.9-2.42.2-1.9
Stereotopy head waving bouts, day 32.32.72.81.6-1.61.7
Stereotopy head waving duration, day 30.20.20.30.3-0.50.5
Locomotion velocity, session 71.01.01.7-0.81.3-0.9
Locomotion distance, session 72.93.74.4-2.02.1-1.7
Stereotopy head waving bouts, day 74.95.76.42.3-2.42.5
Stereotopy head waving duration, day 72.83.43.71.8-1.91.9
Locomotion velocity, session 80.10.10.1-0.30.0-0.3
Locomotion distance, session 81.11.62.3-1.51.1-1.1
Degree of sensitization distance0.50.50.70.8-0.70.7
Degree of sensitization stereotypy3.13.44.11.7-1.82.0
Conditioned locomotion0.10.10.3-0.60.1-0.2
Cocaine response after cond. corrected0.10.10.30.2-0.60.2
Cocaine response after cond. not corrected0.00.00.0-0.0-0.2-0.1
Cocaine response before conditioning1.21.51.9-1.01.4-1.3
Saline control response0.00.00.1-0.00.4-0.2
Bone: connectivity density0.10.10.2-0.40.4-0.1
Bone: cortical apparent density2.13.34.31.6-1.72.1
Bone: cortical area0.40.71.01.0-0.80.7
Bone: cortical porosity1.21.31.7-1.31.1-0.9
Bone: cortical porosity1.21.31.7-1.31.2-0.9
Bone: cortical thickness0.20.30.40.6-0.50.6
Bone: cortical thickness0.40.51.1-1.00.6-0.4
Bone: cortical tissue density1.93.04.01.5-1.72.0
Condit. Reinf. active minus inactive responses0.10.10.3-0.50.20.0
Condit. Reinf. active-inactive response ratio0.30.40.5-0.70.6-0.5
Condit. Reinf. active responses0.30.30.8-0.90.4-0.0
Condit. Reinf. inactive responses0.20.30.6-0.80.30.2
Incentive salience index mean0.00.00.1-0.1-0.10.3
Condit. Reinf. lever presses0.60.91.10.9-0.91.1
Condit. Reinf. active minus inactive responses0.71.11.71.3-1.00.8
Condit. Reinf. active-inactive response ratio0.20.30.50.7-0.50.3
Condit. Reinf. active responses0.81.22.01.4-1.00.7
Condit. Reinf. inactive responses0.10.20.30.5-0.40.3
Condit. Reinf. lever presses0.50.71.0-0.50.9-1.0
Condit. Reinf. lever reinforcers received0.20.30.70.9-0.40.2
Conditioned reinforcement - actives0.00.20.30.10.5-0.5
Conditioned reinforcement - inactives0.30.91.3-0.41.1-1.1
Conditioned locomotion0.40.60.9-0.20.9-0.9
Patch foraging indifference point 0 sec0.20.60.8-0.50.9-0.9
Patch foraging indifference point AUC0.20.40.60.8-0.60.3
Delay disc. indifference point, 0s delay0.00.00.00.10.1-0.2
Delay disc. indifference point, 16s delay0.00.00.10.30.2-0.2
Delay disc. indifference point, 2s delay5.76.37.02.7-2.62.3
Delay disc. indifference point, 24s delay0.00.00.10.30.00.1
Delay disc. indifference point, 4s delay0.10.10.20.4-0.10.3
Delay disc. indifference point, 8s delay0.20.30.5-0.50.7-0.5
Indifference point function ln k0.10.30.6-0.3-0.30.7
Indifference point function log k0.10.30.6-0.3-0.30.7
Patch foraging total patch changes 0 sec0.41.21.4-1.01.2-1.2
Patch foraging total patch changes 12 sec0.20.20.50.10.4-0.7
Patch foraging total patch changes 18 sec0.20.51.0-0.20.6-1.0
Patch foraging total patch changes 24 sec0.10.20.30.30.4-0.5
Patch foraging total patch changes 6 sec0.20.40.90.20.5-1.0
Patch foraging time to switch 0 sec0.00.20.20.5-0.40.3
Patch foraging water rate 0 sec0.00.00.0-0.1-0.10.2
Patch foraging water rate 12 sec0.10.61.3-1.10.5-0.5
Patch foraging water rate 18 sec0.00.00.00.0-0.20.2
Patch foraging water rate 24 sec0.40.50.60.7-0.70.8
Patch foraging water rate 6 sec0.10.10.3-0.60.20.1
Seeking ratio, delayed vs. immediate footshock0.00.10.1-0.20.2-0.2
Distance traveled before self-admin0.10.20.2-0.00.5-0.5
Distance traveled after self-admin2.03.54.4-1.32.1-2.1
Extensor digitorum longus weight7.730.831.75.4-5.65.6
Bone: elastic displacement4.05.15.5-2.32.2-2.3
Bone: elastic work2.83.74.0-2.01.8-1.9
Bone: endosteal estimation0.10.30.50.7-0.50.5
Bone: endosteal perimeter0.41.01.21.1-1.10.7
Epididymis fat weight1.99.610.8-3.33.0-3.0
Delta time in closed arm before/after self-admin0.10.10.10.20.3-0.3
Delta time in open arm before/after self-admin2.53.04.0-2.01.6-1.5
Diff in mean of infusions in LGA sessions0.71.31.80.8-1.21.3
Delay discount exponential model param0.10.10.3-0.50.2-0.2
Extinction: sum of active levers before priming0.91.41.51.1-1.21.2
Active lever presses in extinction session 60.50.50.8-0.20.8-0.9
Bone: final force0.10.20.30.5-0.40.3
Bone: final moment0.10.10.30.5-0.30.2
Food consumed during 24 hour testing period0.50.91.3-0.90.9-1.1
Glucose0.20.30.5-0.70.4-0.6
Heart weight0.30.40.6-0.40.7-0.8
Delay discount hyperbolic model param0.20.30.5-0.70.4-0.4
Intermittent access intake day 1-15 change0.21.11.4-0.81.1-1.2
Intermittent access intake escalation0.10.40.5-0.40.7-0.7
Intermittent access intake escalation 20.40.71.0-0.60.9-1.0
Intermitt. access day 1 inactive lever presses0.00.41.21.1-0.20.2
Intermitt. access day 15 inactive lever presses0.00.10.2-0.20.4-0.3
Intermitt. access escalation Index0.62.02.61.6-1.31.3
Intermittent access day 1 total infusions0.10.20.20.20.5-0.5
Intermittent access day 15 total infusions0.10.10.20.00.5-0.5
Intermittent access terminal intake (last 3 days)0.10.10.20.30.4-0.4
Intermittent access total infusions0.20.20.30.50.4-0.4
Intermittent access day 1 locomotion0.30.60.80.10.9-0.9
Intermittent access day 15 total locomotion0.93.64.4-1.42.1-2.1
Intermittent access total locomotion1.21.42.1-0.41.4-1.4
Intermittent access standard deviation0.62.93.8-1.12.0-1.9
Left kidney weight0.00.20.30.3-0.50.4
Right kidney weight0.11.01.40.6-1.11.2
Cocaine induced anxiety0.00.00.1-0.3-0.00.0
Post-drug Anxiety0.20.20.3-0.50.4-0.4
Baseline Anxiety0.00.00.0-0.1-0.20.2
Tail length0.10.71.2-1.10.8-0.4
Length with tail0.00.20.4-0.70.10.1
Length without tail0.00.00.1-0.0-0.20.3
Times rat made contact with spout0.60.70.8-0.90.8-0.8
Lifetime Intake0.40.50.70.30.8-0.9
Liver weight, left0.10.10.10.4-0.20.4
Liver weight, right0.00.00.1-0.20.3-0.0
Locomotor activity0.20.30.4-0.30.6-0.6
Locomotor testing distance0.40.91.1-0.71.1-1.1
Locomotor testing rearing0.20.91.4-0.71.2-0.9
Locomotion in novel chamber1.21.62.41.6-1.01.1
Locomotion in novel chamber post-restriction0.20.50.60.80.6-0.7
Fecal boli incidents, locomotor time 11.33.53.9-2.01.8-1.8
Change in fecal boli incidents, locomotor task0.80.91.10.8-1.10.9
Time >=10cm from walls, locomotor time 10.30.40.8-0.90.5-0.3
Bouts of movement, locomotor time 10.10.20.3-0.50.50.0
Total resting periods, locomotor time 10.50.61.1-1.10.8-0.2
Rest time, locomotor task time 10.30.50.8-0.90.7-0.4
Distance moved, locomotor task time 10.30.71.71.3-0.70.4
Vertical activity count, locomotor time 10.32.23.31.8-1.41.2
Time >=10cm from walls, locomotor time 20.10.30.4-0.50.7-0.5
Bouts of movement, locomotor time 20.61.82.61.6-1.21.2
Total resting periods, locomotor time 20.62.63.41.8-1.51.5
Rest time, locomotor task time 20.00.00.1-0.3-0.20.0
Distance moved, locomotor task time 20.00.00.00.1-0.00.2
Vertical activity count, locomotor time 20.10.20.30.6-0.30.5
Light reinforcement 10.00.10.10.20.2-0.3
Light reinforcement 20.00.00.0-0.2-0.2-0.0
Bone: marrow area0.10.30.40.6-0.40.4
Bone: maximum diameter0.30.60.90.9-0.70.6
Bone: maximum force0.61.21.31.1-1.01.1
Bone: maximum moment0.50.91.11.1-0.81.0
Mean time between licks in bursts0.31.62.0-1.21.4-1.1
Mean num. licks in bursts0.51.31.8-1.21.3-0.8
Cd content in liver0.20.20.3-0.50.5-0.4
Co content in liver0.20.20.30.5-0.40.5
Cu content in liver0.10.10.30.60.2-0.2
Fe content in liver0.20.20.5-0.10.7-0.5
K content in liver0.00.00.00.1-0.1-0.2
Mg content in liver0.20.20.3-0.40.4-0.6
Mn content in liver0.10.10.20.1-0.40.4
Na content in liver0.10.10.20.00.2-0.4
Rb content in liver0.30.40.7-0.20.8-0.7
Se content in liver0.81.01.2-0.91.1-0.9
Sr content in liver0.30.20.4-0.70.4-0.3
Zn content in liver0.91.01.2-1.10.9-1.1
Bone: minimum diameter0.61.11.41.2-0.91.0
Time in familiar zone, hab. session 10.30.30.7-0.80.4-0.2
Time in novel zone, hab. session 11.61.82.51.6-1.41.0
Total zone transitions, hab. session 10.81.11.30.8-1.11.1
Total locomotion distance, hab. session 10.10.20.4-0.60.1-0.2
Locomotion velocity, hab. session 10.20.30.6-0.80.3-0.3
Time in familiar zone, hab. session 20.10.10.2-0.40.4-0.2
Time in novel zone, hab. session 20.60.70.80.9-0.80.7
Total zone transitions, hab. session 20.10.10.3-0.50.3-0.2
Total locomotion distance, hab. session 20.20.30.7-0.80.3-0.3
Locomotion velocity, hab. session 20.40.51.1-1.00.5-0.5
Novel to familiar place preference ratio1.52.03.31.0-1.31.8
Novelty place preference1.21.52.70.8-1.11.6
Time in novel zone, NPP test1.41.72.90.9-1.21.7
Total zone transitions, NPP test0.20.30.7-0.80.5-0.3
Total locomotion distance, NPP test1.21.62.8-1.71.1-1.0
Locomotion velocity, NPP test1.42.13.4-1.91.2-1.1
Intraocular pressure0.91.52.2-0.61.4-1.5
Delta distance traveled before/after self-admin5.05.55.8-2.22.4-2.4
Delta ambulatory time before/after self-admin3.05.15.7-2.02.3-2.4
Parametrial fat weight1.12.73.0-1.51.7-1.7
Pavlov. Cond. lever latency1.31.72.3-1.51.1-1.2
Pavlov. Cond. magazine entry latency2.43.03.61.9-1.71.6
Pavlov. Cond. change in total contacts3.74.04.22.0-1.92.0
Pavlov. Cond. index score3.84.85.92.4-2.12.0
Pavlov. Cond. latency score3.44.45.62.4-1.91.9
Pavlov. Cond. lever contacts1.41.72.41.5-1.21.2
Pavlov. Cond. magazine entry number1.62.02.6-1.61.4-1.2
Pavlov. Cond. intertrial magazine entries1.62.02.0-1.41.4-1.4
Pavlov. Cond. lever-magazine prob. diff.3.64.55.72.4-2.01.9
Pavlov. Cond. response bias1.01.31.61.3-1.20.9
Pavlov. Cond. lever latency1.31.82.01.3-1.41.4
Pavlov. Cond. magazine entry latency2.12.93.6-1.91.7-1.5
Pavlov. Cond. change in total contacts0.51.11.11.0-1.11.1
Pavlov. Cond. index score1.11.72.1-1.51.3-1.1
Pavlov. Cond. latency score1.01.62.0-1.41.2-1.1
Pavlov. Cond. lever contacts1.62.32.7-1.61.5-1.4
Pavlov. Cond. magazine entry number0.70.91.11.0-0.90.9
Pavlov. Cond. intertrial magazine entries0.61.41.7-1.11.1-1.3
Pavlov. Cond. lever-magazine prob. diff.0.71.11.5-1.21.1-0.9
Pavlov. Cond. response bias1.72.42.4-1.51.5-1.6
Time in closed arm before self-admin1.42.42.91.4-1.71.6
Time in closed arm after self-admin2.42.74.22.1-1.41.4
Time in open arm before self-admin0.70.91.21.1-0.80.8
Time in open arm after self-admin0.50.51.2-1.10.4-0.4
Bone: periosteal estimation0.30.81.21.1-0.80.8
Bone: periosteal perimeter1.22.32.61.6-1.51.4
Bone: post-yield work0.20.30.50.7-0.50.5
Progressive ratio test 1 active lever presses0.71.31.9-0.41.3-1.4
Progressive ratio test 1 breakpoint0.91.52.2-0.61.4-1.5
Progressive ratio test 1 inactive lever presses0.10.30.90.90.2-0.1
Progressive ratio test 2 active lever presses0.10.20.30.50.3-0.3
Progressive ratio test 2 breakpoint0.10.20.50.70.1-0.2
Progressive ratio test 2 inactive lever presses0.20.71.1-0.01.0-1.0
Incentive Sensitization - Responses0.30.70.91.0-0.80.8
Incentive Sensitization - Breakpoint0.41.01.31.1-0.90.9
Sum of active levers in priming session hrs 5-60.20.20.30.5-0.30.3
Progressive ratio0.00.10.20.20.3-0.4
Food seeking constrained by brief footshock0.40.40.80.30.9-0.7
Seeking ratio, punishment vs. effort0.00.00.00.00.20.1
Retroperitoneal fat weight2.912.813.9-3.43.6-3.7
Reaction time number correct0.20.71.7-1.30.5-0.3
Reaction time mean minus median0.00.20.30.40.3-0.5
Reaction time mean minus median AUC0.00.20.40.70.0-0.2
Reaction time num false alarms0.10.10.4-0.60.1-0.1
Reaction time num false alarms AUC0.00.00.1-0.4-0.10.0
Reaction time trials correct on left0.20.71.7-1.30.5-0.3
Reaction time trials on left0.20.71.8-1.30.5-0.3
Reaction time mean0.10.10.40.60.0-0.2
Reaction time mean AUC0.10.10.40.6-0.0-0.2
Median of all reaction times0.00.10.20.5-0.0-0.1
Reaction time omissions0.30.50.7-0.70.9-0.6
Reaction time false alarm rate0.20.30.40.6-0.60.5
Reaction time premature initiation rate1.11.82.2-1.01.5-1.4
Reaction time premature initiations0.92.62.7-1.71.6-1.5
Std. dev. reaction times0.10.20.40.60.1-0.4
Reaction time trials completed0.20.71.8-1.30.5-0.3
Reaction time trials AUC0.10.51.4-1.20.4-0.1
Run reversals in cocaine runway, females0.00.00.1-0.30.1-0.1
Run reversals in cocaine runway, males1.92.12.61.2-1.51.6
Latency to leave start box in cocaine runway0.10.20.20.5-0.30.4
Latency to leave start box in cocaine runway, F0.10.20.30.5-0.30.4
Latency to leave start box in cocaine runway, M0.10.10.10.3-0.30.3
Std. dev. time between licks in bursts1.02.02.1-1.51.4-1.4
Total sessions with >9 infusions0.30.30.40.60.6-0.6
Short access day 1 total inactive lever presses0.10.30.5-0.00.7-0.6
Short access day 10 total inactive lever presses0.00.10.20.5-0.20.1
Short access day 1 total infusions0.40.71.10.01.0-1.1
Short access day 10 total infusions0.10.10.30.60.3-0.2
Short access total infusions0.81.11.70.11.3-1.3
Short access day 1 locomotion0.00.10.10.30.1-0.2
Short access day 10 total locomotion0.00.10.10.40.2-0.2
Short access total locomotion0.20.30.40.50.6-0.6
One hour access (0.3 mA shock)0.60.71.71.3-0.40.4
Compulsive drug intake0.71.01.41.2-0.90.9
One hour access (shock baseline)0.10.10.40.7-0.00.0
Social response proportion1.72.12.9-1.31.7-1.3
Social responses0.20.30.4-0.60.6-0.3
Social time1.01.51.7-1.31.2-1.2
Soleus weight0.00.00.0-0.20.10.1
Bone: stiffness2.13.94.12.0-1.92.0
Tibialis anterior weight11.338.940.46.1-6.46.3
Time to tail flick, vehicle, before self-admin0.20.30.40.60.4-0.5
Time to tail flick, vehicle, after self-admin0.30.50.80.3-0.90.8
Time to tail flick, test, before self-admin0.20.30.30.5-0.60.5
Time to tail flick, test, after self-admin0.40.50.60.8-0.60.6
Delta time to tail flick, vehicle, before/after SA0.10.10.2-0.5-0.30.3
Delta time to tail flick, test, before/after SA0.00.00.00.20.00.0
Tibia length0.00.00.10.10.1-0.3
Ambulatory time before self-admin0.10.40.6-0.20.8-0.7
Ambulatory time after self-admin2.54.05.1-1.42.3-2.2
Bone: tissue strength0.80.81.51.2-0.80.5
Total heroin consumption0.10.20.30.10.5-0.4
Bone: trabecular number0.10.20.3-0.50.5-0.3
Bone: trabecular spacing0.30.40.90.9-0.50.3
Bone: trabecular thickness0.40.61.20.3-0.81.1
Bone: trabecular tissue density2.74.75.31.9-2.32.3
Water consumed over 24 hours0.51.01.6-0.80.9-1.3
Number of responses in last shaping day0.40.50.6-0.8-0.60.7