Hub : Genes

Krt75

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	NAcc	gene expression	Krt75	0.05	0.04	3.5e-09	0.05	0.06	0.05	0.06	1.3e-08	6.2e-10	1.8e-08	2.7e-09
2	Eye	intron excision ratio	chr7_134573721_134573960	0.29	0.2	8.9e-03	0.09	0.06	0.03	0.06	1.6e-02	3.8e-02	1.2e-01	4.4e-02
3	BLA	gene expression	Krt75	0.11	0.1	3.6e-03	0.06	0.05	0.02	0.05	6.8e-04	1.0e-03	4.4e-02	8.7e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bone: apparent density	0.2	0.3	0.6	0.3	0.4	-0.8
Area under the delay curve	0.0	0.0	0.1	0.4	0.0	-0.1
BMI with tail	1.7	5.9	6.7	2.4	2.6	-2.3
BMI without tail	0.7	2.2	2.7	1.4	1.6	-1.4
Body weight	0.5	2.1	2.7	1.1	1.6	-1.5
Weight adjusted by age	1.1	1.6	2.1	0.8	1.5	-1.5
Bone surface	0.3	0.5	0.6	0.7	0.6	-0.8
Bone volume	0.6	1.0	1.5	0.9	0.8	-1.2
Breakpoint value in progressive ratio session	0.0	0.1	0.2	0.4	-0.0	-0.0
Number of licking bursts	0.1	0.1	0.3	0.3	0.5	-0.1
Context. condit. distance diff. score	0.0	0.0	0.0	0.0	-0.0	-0.0
Locomotion velocity, session 1	2.9	3.1	5.2	-2.3	-1.5	1.4
Locomotion distance, session 1	0.4	0.5	0.9	-1.0	-0.3	0.7
Locomotion velocity, session 2	2.0	2.4	4.1	-2.0	-1.3	1.2
Locomotion distance, session 2	0.5	0.8	1.4	-1.2	-0.6	0.7
Locomotion velocity, session 3	3.9	4.4	6.5	-2.5	-1.9	1.7
Locomotion distance, session 3	4.3	4.7	5.9	-2.4	-2.2	1.9
Stereotopy head waving bouts, day 3	2.3	2.7	2.8	1.6	1.6	-1.7
Stereotopy head waving duration, day 3	0.2	0.2	0.3	0.3	0.5	-0.5
Locomotion velocity, session 7	1.0	1.0	1.7	-0.8	-1.3	0.9
Locomotion distance, session 7	2.9	3.7	4.4	-2.0	-2.1	1.7
Stereotopy head waving bouts, day 7	5.1	5.7	6.4	2.3	2.4	-2.5
Stereotopy head waving duration, day 7	2.9	3.4	3.7	1.8	1.9	-1.9
Locomotion velocity, session 8	0.1	0.1	0.1	-0.3	-0.0	0.3
Locomotion distance, session 8	1.1	1.6	2.3	-1.5	-1.1	1.1
Degree of sensitization distance	0.5	0.5	0.7	0.8	0.7	-0.7
Degree of sensitization stereotypy	3.2	3.4	4.1	1.7	1.8	-2.0
Conditioned locomotion	0.1	0.1	0.3	-0.6	-0.1	0.2
Cocaine response after cond. corrected	0.1	0.1	0.3	0.2	0.6	-0.2
Cocaine response after cond. not corrected	0.0	0.0	0.0	-0.0	0.2	0.1
Cocaine response before conditioning	1.3	1.5	1.9	-1.0	-1.4	1.3
Saline control response	0.0	0.0	0.1	-0.0	-0.4	0.2
Bone: connectivity density	0.1	0.1	0.2	-0.4	-0.4	0.1
Bone: cortical apparent density	2.4	3.3	4.3	1.6	1.7	-2.1
Bone: cortical area	0.4	0.7	1.0	1.0	0.8	-0.7
Bone: cortical porosity	1.2	1.3	1.7	-1.3	-1.1	0.9
Bone: cortical porosity	1.2	1.3	1.7	-1.3	-1.2	0.9
Bone: cortical thickness	0.2	0.3	0.4	0.6	0.5	-0.6
Bone: cortical thickness	0.5	0.5	1.1	-1.0	-0.6	0.4
Bone: cortical tissue density	2.2	3.0	4.0	1.5	1.7	-2.0
Condit. Reinf. active minus inactive responses	0.1	0.1	0.3	-0.5	-0.2	-0.0
Condit. Reinf. active-inactive response ratio	0.3	0.4	0.5	-0.7	-0.6	0.5
Condit. Reinf. active responses	0.3	0.3	0.8	-0.9	-0.4	0.0
Condit. Reinf. inactive responses	0.2	0.3	0.6	-0.8	-0.3	-0.2
Incentive salience index mean	0.0	0.0	0.1	-0.1	0.1	-0.3
Condit. Reinf. lever presses	0.7	0.9	1.1	0.9	0.9	-1.1
Condit. Reinf. active minus inactive responses	0.8	1.1	1.7	1.3	1.0	-0.8
Condit. Reinf. active-inactive response ratio	0.3	0.3	0.5	0.7	0.5	-0.3
Condit. Reinf. active responses	0.8	1.2	2.0	1.4	1.0	-0.7
Condit. Reinf. inactive responses	0.1	0.2	0.3	0.5	0.4	-0.3
Condit. Reinf. lever presses	0.5	0.7	1.0	-0.5	-0.9	1.0
Condit. Reinf. lever reinforcers received	0.2	0.3	0.7	0.9	0.4	-0.2
Conditioned reinforcement - actives	0.1	0.2	0.3	0.1	-0.5	0.5
Conditioned reinforcement - inactives	0.6	0.9	1.3	-0.4	-1.1	1.1
Conditioned locomotion	0.4	0.6	0.9	-0.2	-0.9	0.9
Patch foraging indifference point 0 sec	0.3	0.6	0.8	-0.5	-0.9	0.9
Patch foraging indifference point AUC	0.3	0.4	0.6	0.8	0.6	-0.3
Delay disc. indifference point, 0s delay	0.0	0.0	0.0	0.1	-0.1	0.2
Delay disc. indifference point, 16s delay	0.0	0.0	0.1	0.3	-0.2	0.2
Delay disc. indifference point, 2s delay	5.7	6.3	7.0	2.7	2.6	-2.3
Delay disc. indifference point, 24s delay	0.0	0.0	0.1	0.3	-0.0	-0.1
Delay disc. indifference point, 4s delay	0.1	0.1	0.2	0.4	0.1	-0.3
Delay disc. indifference point, 8s delay	0.3	0.3	0.5	-0.5	-0.7	0.5
Indifference point function ln k	0.1	0.3	0.6	-0.3	0.3	-0.7
Indifference point function log k	0.1	0.3	0.6	-0.3	0.3	-0.7
Patch foraging total patch changes 0 sec	0.7	1.2	1.4	-1.0	-1.2	1.2
Patch foraging total patch changes 12 sec	0.2	0.2	0.5	0.1	-0.4	0.7
Patch foraging total patch changes 18 sec	0.3	0.5	1.0	-0.2	-0.6	1.0
Patch foraging total patch changes 24 sec	0.1	0.2	0.3	0.3	-0.4	0.5
Patch foraging total patch changes 6 sec	0.3	0.4	0.9	0.2	-0.5	1.0
Patch foraging time to switch 0 sec	0.1	0.2	0.2	0.5	0.4	-0.3
Patch foraging water rate 0 sec	0.0	0.0	0.0	-0.1	0.1	-0.2
Patch foraging water rate 12 sec	0.3	0.6	1.3	-1.1	-0.5	0.5
Patch foraging water rate 18 sec	0.0	0.0	0.0	0.0	0.2	-0.2
Patch foraging water rate 24 sec	0.4	0.5	0.6	0.7	0.7	-0.8
Patch foraging water rate 6 sec	0.1	0.1	0.3	-0.6	-0.2	-0.1
Seeking ratio, delayed vs. immediate footshock	0.0	0.1	0.1	-0.2	-0.2	0.2
Distance traveled before self-admin	0.1	0.2	0.2	-0.0	-0.5	0.5
Distance traveled after self-admin	2.9	3.5	4.4	-1.3	-2.1	2.1
Extensor digitorum longus weight	7.8	30.8	31.7	5.4	5.6	-5.6
Bone: elastic displacement	4.4	5.1	5.5	-2.3	-2.2	2.3
Bone: elastic work	2.8	3.7	4.0	-2.0	-1.8	1.9
Bone: endosteal estimation	0.1	0.3	0.5	0.7	0.5	-0.5
Bone: endosteal perimeter	0.5	1.0	1.2	1.1	1.1	-0.7
Epididymis fat weight	2.8	9.6	10.8	-3.3	-3.0	3.0
Delta time in closed arm before/after self-admin	0.1	0.1	0.1	0.2	-0.3	0.3
Delta time in open arm before/after self-admin	3.0	3.0	4.0	-2.0	-1.6	1.5
Diff in mean of infusions in LGA sessions	1.1	1.3	1.8	0.8	1.2	-1.3
Delay discount exponential model param	0.1	0.1	0.3	-0.5	-0.2	0.2
Extinction: sum of active levers before priming	1.2	1.4	1.5	1.1	1.2	-1.2
Active lever presses in extinction session 6	0.5	0.5	0.8	-0.2	-0.8	0.9
Bone: final force	0.1	0.2	0.3	0.5	0.4	-0.3
Bone: final moment	0.1	0.1	0.3	0.5	0.3	-0.2
Food consumed during 24 hour testing period	0.7	0.9	1.3	-0.9	-0.9	1.1
Glucose	0.2	0.3	0.5	-0.7	-0.4	0.6
Heart weight	0.3	0.4	0.6	-0.4	-0.7	0.8
Delay discount hyperbolic model param	0.2	0.3	0.5	-0.7	-0.4	0.4
Intermittent access intake day 1-15 change	0.5	1.1	1.4	-0.8	-1.1	1.2
Intermittent access intake escalation	0.2	0.4	0.5	-0.4	-0.7	0.7
Intermittent access intake escalation 2	0.6	0.7	1.0	-0.6	-0.9	1.0
Intermitt. access day 1 inactive lever presses	0.1	0.4	1.2	1.1	0.2	-0.2
Intermitt. access day 15 inactive lever presses	0.0	0.1	0.2	-0.2	-0.4	0.3
Intermitt. access escalation Index	1.4	2.0	2.6	1.6	1.3	-1.3
Intermittent access day 1 total infusions	0.1	0.2	0.2	0.2	-0.5	0.5
Intermittent access day 15 total infusions	0.1	0.1	0.2	0.0	-0.5	0.5
Intermittent access terminal intake (last 3 days)	0.1	0.1	0.2	0.3	-0.4	0.4
Intermittent access total infusions	0.2	0.2	0.3	0.5	-0.4	0.4
Intermittent access day 1 locomotion	0.4	0.6	0.8	0.1	-0.9	0.9
Intermittent access day 15 total locomotion	2.0	3.6	4.4	-1.4	-2.1	2.1
Intermittent access total locomotion	1.2	1.4	2.1	-0.4	-1.4	1.4
Intermittent access standard deviation	1.4	2.9	3.8	-1.1	-2.0	1.9
Left kidney weight	0.0	0.2	0.3	0.3	0.5	-0.4
Right kidney weight	0.2	1.0	1.4	0.6	1.1	-1.2
Cocaine induced anxiety	0.0	0.0	0.1	-0.3	0.0	-0.0
Post-drug Anxiety	0.2	0.2	0.3	-0.5	-0.4	0.4
Baseline Anxiety	0.0	0.0	0.0	-0.1	0.2	-0.2
Tail length	0.2	0.7	1.2	-1.1	-0.8	0.4
Length with tail	0.0	0.2	0.4	-0.7	-0.1	-0.1
Length without tail	0.0	0.0	0.1	-0.0	0.2	-0.3
Times rat made contact with spout	0.6	0.7	0.8	-0.9	-0.8	0.8
Lifetime Intake	0.4	0.5	0.7	0.3	-0.8	0.9
Liver weight, left	0.1	0.1	0.1	0.4	0.2	-0.4
Liver weight, right	0.0	0.0	0.1	-0.2	-0.3	0.0
Locomotor activity	0.2	0.3	0.4	-0.3	-0.6	0.6
Locomotor testing distance	0.5	0.9	1.1	-0.7	-1.1	1.1
Locomotor testing rearing	0.4	0.9	1.4	-0.7	-1.2	0.9
Locomotion in novel chamber	1.2	1.6	2.4	1.6	1.0	-1.1
Locomotion in novel chamber post-restriction	0.3	0.5	0.6	0.8	-0.6	0.7
Fecal boli incidents, locomotor time 1	2.4	3.5	3.9	-2.0	-1.8	1.8
Change in fecal boli incidents, locomotor task	0.9	0.9	1.1	0.8	1.1	-0.9
Time >=10cm from walls, locomotor time 1	0.4	0.4	0.8	-0.9	-0.5	0.3
Bouts of movement, locomotor time 1	0.2	0.2	0.3	-0.5	-0.5	-0.0
Total resting periods, locomotor time 1	0.5	0.6	1.1	-1.1	-0.8	0.2
Rest time, locomotor task time 1	0.4	0.5	0.8	-0.9	-0.7	0.4
Distance moved, locomotor task time 1	0.5	0.7	1.7	1.3	0.7	-0.4
Vertical activity count, locomotor time 1	0.9	2.2	3.3	1.8	1.4	-1.2
Time >=10cm from walls, locomotor time 2	0.2	0.3	0.4	-0.5	-0.7	0.5
Bouts of movement, locomotor time 2	1.1	1.8	2.6	1.6	1.2	-1.2
Total resting periods, locomotor time 2	1.5	2.6	3.4	1.8	1.5	-1.5
Rest time, locomotor task time 2	0.0	0.0	0.1	-0.3	0.2	-0.0
Distance moved, locomotor task time 2	0.0	0.0	0.0	0.1	0.0	-0.2
Vertical activity count, locomotor time 2	0.1	0.2	0.3	0.6	0.3	-0.5
Light reinforcement 1	0.0	0.1	0.1	0.2	-0.2	0.3
Light reinforcement 2	0.0	0.0	0.0	-0.2	0.2	0.0
Bone: marrow area	0.1	0.3	0.4	0.6	0.4	-0.4
Bone: maximum diameter	0.3	0.6	0.9	0.9	0.7	-0.6
Bone: maximum force	0.7	1.2	1.3	1.1	1.0	-1.1
Bone: maximum moment	0.5	0.9	1.1	1.1	0.8	-1.0
Mean time between licks in bursts	0.6	1.6	2.0	-1.2	-1.4	1.1
Mean num. licks in bursts	0.8	1.3	1.8	-1.2	-1.3	0.8
Cd content in liver	0.2	0.2	0.3	-0.5	-0.5	0.4
Co content in liver	0.2	0.2	0.3	0.5	0.4	-0.5
Cu content in liver	0.1	0.1	0.3	0.6	-0.2	0.2
Fe content in liver	0.2	0.2	0.5	-0.1	-0.7	0.5
K content in liver	0.0	0.0	0.0	0.1	0.1	0.2
Mg content in liver	0.2	0.2	0.3	-0.4	-0.4	0.6
Mn content in liver	0.1	0.1	0.2	0.1	0.4	-0.4
Na content in liver	0.1	0.1	0.2	0.0	-0.2	0.4
Rb content in liver	0.4	0.4	0.7	-0.2	-0.8	0.7
Se content in liver	0.8	1.0	1.2	-0.9	-1.1	0.9
Sr content in liver	0.3	0.2	0.4	-0.7	-0.4	0.3
Zn content in liver	0.9	1.0	1.2	-1.1	-0.9	1.1
Bone: minimum diameter	0.6	1.1	1.4	1.2	0.9	-1.0
Time in familiar zone, hab. session 1	0.3	0.3	0.7	-0.8	-0.4	0.2
Time in novel zone, hab. session 1	1.8	1.8	2.5	1.6	1.4	-1.0
Total zone transitions, hab. session 1	0.8	1.1	1.3	0.8	1.1	-1.1
Total locomotion distance, hab. session 1	0.1	0.2	0.4	-0.6	-0.1	0.2
Locomotion velocity, hab. session 1	0.2	0.3	0.6	-0.8	-0.3	0.3
Time in familiar zone, hab. session 2	0.1	0.1	0.2	-0.4	-0.4	0.2
Time in novel zone, hab. session 2	0.6	0.7	0.8	0.9	0.8	-0.7
Total zone transitions, hab. session 2	0.1	0.1	0.3	-0.5	-0.3	0.2
Total locomotion distance, hab. session 2	0.2	0.3	0.7	-0.8	-0.3	0.3
Locomotion velocity, hab. session 2	0.4	0.5	1.1	-1.0	-0.5	0.5
Novel to familiar place preference ratio	1.8	2.0	3.3	1.0	1.3	-1.8
Novelty place preference	1.4	1.5	2.7	0.8	1.1	-1.6
Time in novel zone, NPP test	1.6	1.7	2.9	0.9	1.2	-1.7
Total zone transitions, NPP test	0.2	0.3	0.7	-0.8	-0.5	0.3
Total locomotion distance, NPP test	1.2	1.6	2.8	-1.7	-1.1	1.0
Locomotion velocity, NPP test	1.5	2.1	3.4	-1.9	-1.2	1.1
Intraocular pressure	1.1	1.5	2.2	-0.6	-1.4	1.5
Delta distance traveled before/after self-admin	5.2	5.5	5.8	-2.2	-2.4	2.4
Delta ambulatory time before/after self-admin	4.2	5.1	5.7	-2.0	-2.3	2.4
Parametrial fat weight	1.1	2.7	3.0	-1.5	-1.7	1.7
Pavlov. Cond. lever latency	1.3	1.7	2.3	-1.5	-1.1	1.2
Pavlov. Cond. magazine entry latency	2.4	3.0	3.6	1.9	1.7	-1.6
Pavlov. Cond. change in total contacts	3.8	4.0	4.2	2.0	1.9	-2.0
Pavlov. Cond. index score	3.8	4.8	5.9	2.4	2.1	-2.0
Pavlov. Cond. latency score	3.4	4.4	5.6	2.4	1.9	-1.9
Pavlov. Cond. lever contacts	1.5	1.7	2.4	1.5	1.2	-1.2
Pavlov. Cond. magazine entry number	1.6	2.0	2.6	-1.6	-1.4	1.2
Pavlov. Cond. intertrial magazine entries	1.6	2.0	2.0	-1.4	-1.4	1.4
Pavlov. Cond. lever-magazine prob. diff.	3.6	4.5	5.7	2.4	2.0	-1.9
Pavlov. Cond. response bias	1.0	1.3	1.6	1.3	1.2	-0.9
Pavlov. Cond. lever latency	1.4	1.8	2.0	1.3	1.4	-1.4
Pavlov. Cond. magazine entry latency	2.4	2.9	3.6	-1.9	-1.7	1.5
Pavlov. Cond. change in total contacts	0.7	1.1	1.1	1.0	1.1	-1.1
Pavlov. Cond. index score	1.3	1.7	2.1	-1.5	-1.3	1.1
Pavlov. Cond. latency score	1.2	1.6	2.0	-1.4	-1.2	1.1
Pavlov. Cond. lever contacts	1.7	2.3	2.7	-1.6	-1.5	1.4
Pavlov. Cond. magazine entry number	0.7	0.9	1.1	1.0	0.9	-0.9
Pavlov. Cond. intertrial magazine entries	0.9	1.4	1.7	-1.1	-1.1	1.3
Pavlov. Cond. lever-magazine prob. diff.	0.9	1.1	1.5	-1.2	-1.1	0.9
Pavlov. Cond. response bias	1.7	2.4	2.4	-1.5	-1.5	1.6
Time in closed arm before self-admin	1.9	2.4	2.9	1.4	1.7	-1.6
Time in closed arm after self-admin	2.5	2.7	4.2	2.1	1.4	-1.4
Time in open arm before self-admin	0.8	0.9	1.2	1.1	0.8	-0.8
Time in open arm after self-admin	0.5	0.5	1.2	-1.1	-0.4	0.4
Bone: periosteal estimation	0.4	0.8	1.2	1.1	0.8	-0.8
Bone: periosteal perimeter	1.3	2.3	2.6	1.6	1.5	-1.4
Bone: post-yield work	0.2	0.3	0.5	0.7	0.5	-0.5
Progressive ratio test 1 active lever presses	1.0	1.3	1.9	-0.4	-1.3	1.4
Progressive ratio test 1 breakpoint	1.3	1.5	2.2	-0.6	-1.4	1.5
Progressive ratio test 1 inactive lever presses	0.2	0.3	0.9	0.9	-0.2	0.1
Progressive ratio test 2 active lever presses	0.2	0.2	0.3	0.5	-0.3	0.3
Progressive ratio test 2 breakpoint	0.2	0.2	0.5	0.7	-0.1	0.2
Progressive ratio test 2 inactive lever presses	0.4	0.7	1.1	-0.0	-1.0	1.0
Incentive Sensitization - Responses	0.5	0.7	0.9	1.0	0.8	-0.8
Incentive Sensitization - Breakpoint	0.7	1.0	1.3	1.1	0.9	-0.9
Sum of active levers in priming session hrs 5-6	0.2	0.2	0.3	0.5	0.3	-0.3
Progressive ratio	0.1	0.1	0.2	0.2	-0.3	0.4
Food seeking constrained by brief footshock	0.4	0.4	0.8	0.3	-0.9	0.7
Seeking ratio, punishment vs. effort	0.0	0.0	0.0	0.0	-0.2	-0.1
Retroperitoneal fat weight	3.0	12.8	13.9	-3.4	-3.6	3.7
Reaction time number correct	0.3	0.7	1.7	-1.3	-0.5	0.3
Reaction time mean minus median	0.1	0.2	0.3	0.4	-0.3	0.5
Reaction time mean minus median AUC	0.1	0.2	0.4	0.7	-0.0	0.2
Reaction time num false alarms	0.1	0.1	0.4	-0.6	-0.1	0.1
Reaction time num false alarms AUC	0.0	0.0	0.1	-0.4	0.1	-0.0
Reaction time trials correct on left	0.3	0.7	1.7	-1.3	-0.5	0.3
Reaction time trials on left	0.4	0.7	1.8	-1.3	-0.5	0.3
Reaction time mean	0.1	0.1	0.4	0.6	-0.0	0.2
Reaction time mean AUC	0.1	0.1	0.4	0.6	0.0	0.2
Median of all reaction times	0.1	0.1	0.2	0.5	0.0	0.1
Reaction time omissions	0.4	0.5	0.7	-0.7	-0.9	0.6
Reaction time false alarm rate	0.2	0.3	0.4	0.6	0.6	-0.5
Reaction time premature initiation rate	1.3	1.8	2.2	-1.0	-1.5	1.4
Reaction time premature initiations	1.5	2.6	2.7	-1.7	-1.6	1.5
Std. dev. reaction times	0.1	0.2	0.4	0.6	-0.1	0.4
Reaction time trials completed	0.4	0.7	1.8	-1.3	-0.5	0.3
Reaction time trials AUC	0.3	0.5	1.4	-1.2	-0.4	0.1
Run reversals in cocaine runway, females	0.0	0.0	0.1	-0.3	-0.1	0.1
Run reversals in cocaine runway, males	2.1	2.1	2.6	1.2	1.5	-1.6
Latency to leave start box in cocaine runway	0.2	0.2	0.2	0.5	0.3	-0.4
Latency to leave start box in cocaine runway, F	0.1	0.2	0.3	0.5	0.3	-0.4
Latency to leave start box in cocaine runway, M	0.1	0.1	0.1	0.3	0.3	-0.3
Std. dev. time between licks in bursts	1.4	2.0	2.1	-1.5	-1.4	1.4
Total sessions with >9 infusions	0.3	0.3	0.4	0.6	-0.6	0.6
Short access day 1 total inactive lever presses	0.2	0.3	0.5	-0.0	-0.7	0.6
Short access day 10 total inactive lever presses	0.0	0.1	0.2	0.5	0.2	-0.1
Short access day 1 total infusions	0.6	0.7	1.1	0.0	-1.0	1.1
Short access day 10 total infusions	0.1	0.1	0.3	0.6	-0.3	0.2
Short access total infusions	0.9	1.1	1.7	0.1	-1.3	1.3
Short access day 1 locomotion	0.0	0.1	0.1	0.3	-0.1	0.2
Short access day 10 total locomotion	0.0	0.1	0.1	0.4	-0.2	0.2
Short access total locomotion	0.3	0.3	0.4	0.5	-0.6	0.6
One hour access (0.3 mA shock)	0.6	0.7	1.7	1.3	0.4	-0.4
Compulsive drug intake	0.8	1.0	1.4	1.2	0.9	-0.9
One hour access (shock baseline)	0.1	0.1	0.4	0.7	0.0	-0.0
Social response proportion	1.9	2.1	2.9	-1.3	-1.7	1.3
Social responses	0.2	0.3	0.4	-0.6	-0.6	0.3
Social time	1.1	1.5	1.7	-1.3	-1.2	1.2
Soleus weight	0.0	0.0	0.0	-0.2	-0.1	-0.1
Bone: stiffness	2.4	3.9	4.1	2.0	1.9	-2.0
Tibialis anterior weight	11.5	38.9	40.4	6.1	6.4	-6.3
Time to tail flick, vehicle, before self-admin	0.3	0.3	0.4	0.6	-0.4	0.5
Time to tail flick, vehicle, after self-admin	0.4	0.5	0.8	0.3	0.9	-0.8
Time to tail flick, test, before self-admin	0.3	0.3	0.3	0.5	0.6	-0.5
Time to tail flick, test, after self-admin	0.4	0.5	0.6	0.8	0.6	-0.6
Delta time to tail flick, vehicle, before/after SA	0.1	0.1	0.2	-0.5	0.3	-0.3
Delta time to tail flick, test, before/after SA	0.0	0.0	0.0	0.2	-0.0	-0.0
Tibia length	0.0	0.0	0.1	0.1	-0.1	0.3
Ambulatory time before self-admin	0.3	0.4	0.6	-0.2	-0.8	0.7
Ambulatory time after self-admin	3.4	4.0	5.1	-1.4	-2.3	2.2
Bone: tissue strength	0.8	0.8	1.5	1.2	0.8	-0.5
Total heroin consumption	0.1	0.2	0.3	0.1	-0.5	0.4
Bone: trabecular number	0.1	0.2	0.3	-0.5	-0.5	0.3
Bone: trabecular spacing	0.3	0.4	0.9	0.9	0.5	-0.3
Bone: trabecular thickness	0.5	0.6	1.2	0.3	0.8	-1.1
Bone: trabecular tissue density	3.2	4.7	5.3	1.9	2.3	-2.3
Water consumed over 24 hours	0.8	1.0	1.6	-0.8	-0.9	1.3
Number of responses in last shaping day	0.4	0.5	0.6	-0.8	0.6	-0.7