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Food seeking constrained by brief footshock

Food seeking constrained by brief footshock punishment. The last successfully completed ratio or shock intensity endured before timeout. Animals are food restricted to 85% of initial body weight, trained to lever-press for food pellets (45 mg) until stable response rates were reached, then tested either on the progressive ratio (PR) task with progressively increasing effort requirements (lever-presses required per pellet) or progressively increasing punishment (i.e., a foot-shock of increasing intensity presented 1 s after food pellet delivery, whose magnitude increases ~25% every 3 trials). In the PR task, rats time out if 2 min passed without a lever press. In the punishment task, a timeout is defined by three consecutive trials with >30 s passing without a lever press. For both tasks, the break point is the last successfully completed ratio or shock intensity endured before timeout.

Tags: Behavior · Motivation

Project: u01_tom_jhou

3 loci · 8 genes with independent associations · 12 total associated genes

Significant Loci

#	Chr	Start pos	End pos	# assoc genes	# joint models	Best TWAS P	Best GWAS P	Cond GWAS P	Joint genes
1	chr1	80926895	83373361	10	6	2.94e-17	2.83e-04	NaN	Vom2r36 Zfp110 Zfp329 Zfp551 Zscan18
2	chr1	88730218	89913275	1	1	2.23e-08	2.02e-05	1e+00	LOC120096890
3	chr9	83390749	84777604	1	1	0.00e+00	1.07e-01	1e+00	Retreg2

Pleiotropic Associations

Trait	Chi2 ratio	# genes+	# genes++	% genes++	Corr	Corr P	Genes
BMI with tail	866.87	1	1	12.5	0	1.00e+00	Retreg2
BMI without tail	57243.66	1	1	12.5	0	1.00e+00	Retreg2
Body weight	3.66	1	0	0	0	1.00e+00	Retreg2
Epididymis fat weight	36276.19	1	1	12.5	0	1.00e+00	Retreg2
Glucose	541.77	1	1	12.5	0	1.00e+00	Retreg2
Heart weight	3065.65	1	1	12.5	0	1.00e+00	Retreg2
Left kidney weight	11011.8	4	1	12.5	0.97	5.60e-03	Retreg2 Vom1r47 Zfp110 Zfp446
Right kidney weight	6735.83	5	1	12.5	0.96	2.83e-03	LOC120096890 Retreg2 Vom1r47 Vom2r36 Zfp110
Tail length	14461.3	2	1	12.5	0	1.00e+00	Retreg2 Zfp110
Length with tail	373.09	3	1	12.5	-0.99	1.33e-02	Retreg2 Vom1r47 Vom2r36
Length without tail	4726.97	8	1	12.5	0.91	3.16e-04	LOC120096890 Retreg2 Vom1r47 Vom2r36 Zfp110 Zfp329 Zfp551 Zscan18
Liver weight, left	3487.23	1	1	12.5	0	1.00e+00	Retreg2
Liver weight, right	47.7	1	1	12.5	0	1.00e+00	Retreg2
Parametrial fat weight	181.56	1	1	12.5	0	1.00e+00	Retreg2
Retroperitoneal fat weight	791.61	4	2	25	-1	2.12e-05	Retreg2 Zfp110 Zfp446 Zfp551
Intraocular pressure	10386.52	1	1	12.5	0	1.00e+00	Retreg2
Extensor digitorum longus weight	540.45	2	1	12.5	0	1.00e+00	LOC120096890 Retreg2
Soleus weight	20.71	1	1	12.5	0	1.00e+00	Retreg2
Tibialis anterior weight	580.96	2	1	12.5	0	1.00e+00	LOC120096890 Retreg2
Tibia length	258.35	3	1	12.5	0	1.00e+00	Retreg2 Zfp110 Zfp446
Number of licking bursts	67424.86	1	1	12.5	0	1.00e+00	Retreg2
Food consumed during 24 hour testing period	35509.41	1	1	12.5	0	1.00e+00	Retreg2
Times rat made contact with spout	71.66	1	1	12.5	0	1.00e+00	Retreg2
Mean time between licks in bursts	111630.35	1	1	12.5	0	1.00e+00	Retreg2
Mean num. licks in bursts	56750.08	1	1	12.5	0	1.00e+00	Retreg2
Std. dev. time between licks in bursts	29750.31	1	1	12.5	0	1.00e+00	Retreg2
Water consumed over 24 hours	34168.6	1	1	12.5	0	1.00e+00	Retreg2
Patch foraging indifference point 0 sec	39171.5	1	1	12.5	0	1.00e+00	Retreg2
Patch foraging indifference point AUC	50128.13	1	1	12.5	0	1.00e+00	Retreg2
Indifference point function ln k	18555.58	2	1	12.5	0	1.00e+00	Retreg2 Zfp110
Indifference point function log k	18555.58	2	1	12.5	0	1.00e+00	Retreg2 Zfp110
Patch foraging total patch changes 0 sec	41947.04	1	1	12.5	0	1.00e+00	Retreg2
Patch foraging total patch changes 12 sec	2302.98	1	1	12.5	0	1.00e+00	Retreg2
Patch foraging total patch changes 18 sec	40454.12	1	1	12.5	0	1.00e+00	Retreg2
Patch foraging total patch changes 24 sec	74801.17	1	1	12.5	0	1.00e+00	Retreg2
Patch foraging total patch changes 6 sec	7787.09	1	1	12.5	0	1.00e+00	Retreg2
Patch foraging time to switch 0 sec	5123.73	6	2	25	-0.92	7.97e-06	Retreg2 Zfp110 Zfp329 Zfp446 Zfp551 Zscan18
Patch foraging water rate 0 sec	60426.37	1	1	12.5	0	1.00e+00	Retreg2
Patch foraging water rate 12 sec	7070.06	6	1	12.5	0.92	1.32e-04	Retreg2 Zfp110 Zfp329 Zfp446 Zfp551 Zscan18
Patch foraging water rate 18 sec	16867.69	2	1	12.5	0	1.00e+00	Retreg2 Zfp110
Patch foraging water rate 24 sec	1033.47	1	1	12.5	0	1.00e+00	Retreg2
Patch foraging water rate 6 sec	422.62	2	1	12.5	0	1.00e+00	Retreg2 Zfp110
Locomotor testing distance	27661.69	1	1	12.5	0	1.00e+00	Retreg2
Locomotor testing rearing	63397.34	1	1	12.5	0	1.00e+00	Retreg2
Light reinforcement 1	66311.75	1	1	12.5	0	1.00e+00	Retreg2
Light reinforcement 2	36738.3	1	1	12.5	0	1.00e+00	Retreg2
Reaction time number correct	63471.78	1	1	12.5	0	1.00e+00	Retreg2
Reaction time mean minus median	119950.29	1	1	12.5	0	1.00e+00	Retreg2
Reaction time mean minus median AUC	123988.85	1	1	12.5	0	1.00e+00	Retreg2
Reaction time num false alarms	15357.42	1	1	12.5	0	1.00e+00	Retreg2
Reaction time num false alarms AUC	35016.83	1	1	12.5	0	1.00e+00	Retreg2
Reaction time trials correct on left	63471.78	1	1	12.5	0	1.00e+00	Retreg2
Reaction time trials on left	60883.54	1	1	12.5	0	1.00e+00	Retreg2
Reaction time mean	29724.21	1	1	12.5	0	1.00e+00	Retreg2
Reaction time mean AUC	38768	1	1	12.5	0	1.00e+00	Retreg2
Median of all reaction times	7893.84	1	1	12.5	0	1.00e+00	Retreg2
Reaction time omissions	8364.84	1	1	12.5	0	1.00e+00	Retreg2
Reaction time false alarm rate	210.6	1	1	12.5	0	1.00e+00	Retreg2
Reaction time premature initiation rate	9733.76	1	1	12.5	0	1.00e+00	Retreg2
Reaction time premature initiations	53743.58	1	1	12.5	0	1.00e+00	Retreg2
Std. dev. reaction times	60865.09	1	1	12.5	0	1.00e+00	Retreg2
Reaction time trials completed	60883.54	1	1	12.5	0	1.00e+00	Retreg2
Reaction time trials AUC	62130.65	1	1	12.5	0	1.00e+00	Retreg2
Social response proportion	2933.22	3	1	12.5	0	1.00e+00	Retreg2 Zfp110 Zfp329
Social responses	1265.33	1	1	12.5	0	1.00e+00	Retreg2
Social time	3889.5	2	1	12.5	0	1.00e+00	Retreg2 Zfp110
Conditioned locomotion	1400.08	1	1	12.5	0	1.00e+00	Retreg2
Cocaine response after cond. corrected	6381.32	2	1	12.5	0	1.00e+00	Retreg2 Zfp110
Cocaine response after cond. not corrected	18571.31	1	1	12.5	0	1.00e+00	Retreg2
Cocaine response before conditioning	171.41	3	1	12.5	1	1.11e-03	Retreg2 Zfp110 Zfp446
Saline control response	3160.68	1	1	12.5	0	1.00e+00	Retreg2
Condit. Reinf. active minus inactive responses	14521.56	1	1	12.5	0	1.00e+00	Retreg2
Condit. Reinf. active-inactive response ratio	28713.86	1	1	12.5	0	1.00e+00	Retreg2
Condit. Reinf. active responses	2302.04	1	1	12.5	0	1.00e+00	Retreg2
Condit. Reinf. inactive responses	10889.7	1	1	12.5	0	1.00e+00	Retreg2
Condit. Reinf. lever presses	3863.86	1	1	12.5	0	1.00e+00	Retreg2
Condit. Reinf. lever reinforcers received	469.54	1	1	12.5	0	1.00e+00	Retreg2
Pavlov. Cond. lever latency	1269.43	2	1	12.5	0	1.00e+00	Retreg2 Zfp110
Pavlov. Cond. magazine entry latency	13282.18	1	1	12.5	0	1.00e+00	Retreg2
Pavlov. Cond. change in total contacts	39811.91	1	1	12.5	0	1.00e+00	Retreg2
Pavlov. Cond. index score	12744.53	1	1	12.5	0	1.00e+00	Retreg2
Pavlov. Cond. latency score	16150.81	1	1	12.5	0	1.00e+00	Retreg2
Pavlov. Cond. lever contacts	5331.08	1	1	12.5	0	1.00e+00	Retreg2
Pavlov. Cond. magazine entry number	4012.39	1	1	12.5	0	1.00e+00	Retreg2
Pavlov. Cond. intertrial magazine entries	34989.79	1	1	12.5	0	1.00e+00	Retreg2
Pavlov. Cond. lever-magazine prob. diff.	11800.43	1	1	12.5	0	1.00e+00	Retreg2
Pavlov. Cond. response bias	1164.95	1	1	12.5	0	1.00e+00	Retreg2
Conditioned reinforcement - actives	33603.04	3	1	12.5	0	1.00e+00	Retreg2 Zfp110 Zfp329
Conditioned reinforcement - inactives	64866.71	1	1	12.5	0	1.00e+00	Retreg2
Conditioned locomotion	10334.01	1	1	12.5	0	1.00e+00	Retreg2
Intermittent access intake day 1-15 change	127876.18	1	1	12.5	0	1.00e+00	Retreg2
Intermittent access intake escalation	42026.59	3	1	12.5	0	1.00e+00	Retreg2 Zfp110 Zfp329
Intermittent access intake escalation 2	36175.43	1	1	12.5	0	1.00e+00	Retreg2
Intermitt. access day 1 inactive lever presses	36126.51	4	1	12.5	-0.96	8.94e-03	Retreg2 Zfp110 Zfp329 Zscan18
Intermitt. access day 15 inactive lever presses	61806.73	2	1	12.5	0	1.00e+00	Retreg2 Zfp110
Intermitt. access escalation Index	93297.07	1	1	12.5	0	1.00e+00	Retreg2
Intermittent access day 1 total infusions	66115.79	1	1	12.5	0	1.00e+00	Retreg2
Intermittent access day 15 total infusions	9755.2	4	1	12.5	-0.97	7.22e-03	Retreg2 Zfp110 Zfp329 Zscan18
Intermittent access terminal intake (last 3 days)	8273.33	3	1	12.5	0	1.00e+00	Retreg2 Zfp110 Zfp329
Intermittent access total infusions	67.35	3	1	12.5	0	1.00e+00	Retreg2 Zfp110 Zfp329
Intermittent access day 1 locomotion	34964.22	1	1	12.5	0	1.00e+00	Retreg2
Intermittent access day 15 total locomotion	85548.8	1	1	12.5	0	1.00e+00	Retreg2
Intermittent access total locomotion	62.33	2	1	12.5	0	1.00e+00	Retreg2 Zfp110
Intermittent access standard deviation	113962.95	1	1	12.5	0	1.00e+00	Retreg2
Cocaine induced anxiety	69097.7	1	1	12.5	0	1.00e+00	Retreg2
Post-drug Anxiety	4753.56	1	1	12.5	0	1.00e+00	Retreg2
Baseline Anxiety	33506.24	1	1	12.5	0	1.00e+00	Retreg2
Lifetime Intake	831.68	2	1	12.5	0	1.00e+00	Retreg2 Zfp110
Incentive Sensitization - Responses	10202.06	5	1	12.5	0.93	2.73e-03	LOC120096890 Retreg2 Zfp110 Zfp329 Zscan18
Incentive Sensitization - Breakpoint	9222.69	5	1	12.5	0.93	7.13e-03	LOC120096890 Retreg2 Zfp110 Zfp329 Zscan18
Progressive ratio test 1 active lever presses	31979.35	1	1	12.5	0	1.00e+00	Retreg2
Progressive ratio test 1 breakpoint	30292.17	1	1	12.5	0	1.00e+00	Retreg2
Progressive ratio test 1 inactive lever presses	31107.5	2	1	12.5	0	1.00e+00	LOC120096890 Retreg2
Progressive ratio test 2 active lever presses	5095.35	3	1	12.5	0	1.00e+00	Retreg2 Zfp110 Zfp329
Progressive ratio test 2 breakpoint	2143.74	4	1	12.5	0.96	4.07e-02	LOC120096890 Retreg2 Zfp110 Zfp329
Progressive ratio test 2 inactive lever presses	36255.82	2	1	12.5	0	1.00e+00	Retreg2 Zfp110
Total sessions with >9 infusions	1959.63	1	1	12.5	0	1.00e+00	Retreg2
Short access day 1 total inactive lever presses	19709.34	2	1	12.5	0	1.00e+00	LOC120096890 Retreg2
Short access day 10 total inactive lever presses	138842.31	1	1	12.5	0	1.00e+00	Retreg2
Short access day 1 total infusions	38385.19	1	1	12.5	0	1.00e+00	Retreg2
Short access day 10 total infusions	22696.46	1	1	12.5	0	1.00e+00	Retreg2
Short access total infusions	8778.92	1	1	12.5	0	1.00e+00	Retreg2
Short access day 1 locomotion	12405.55	2	1	12.5	0	1.00e+00	Retreg2 Zfp110
Short access day 10 total locomotion	88176.71	1	1	12.5	0	1.00e+00	Retreg2
Short access total locomotion	18677.85	1	1	12.5	0	1.00e+00	Retreg2
Compulsive drug intake	18679.82	1	1	12.5	0	1.00e+00	Retreg2
One hour access (0.3 mA shock)	475.22	4	1	12.5	-0.99	1.10e-03	Retreg2 Vom2r36 Zfp110 Zfp329
One hour access (shock baseline)	13752.38	4	1	12.5	-0.98	1.91e-02	LOC120096890 Retreg2 Zfp110 Zfp329
Number of responses in last shaping day	4546.62	3	1	12.5	0	1.00e+00	LOC120096890 Retreg2 Zfp110
Context. condit. distance diff. score	212.47	1	1	12.5	0	1.00e+00	Retreg2
Locomotion velocity, session 1	3523.61	1	1	12.5	0	1.00e+00	Retreg2
Locomotion distance, session 1	517.7	2	1	12.5	0	1.00e+00	Retreg2 Zfp110
Locomotion velocity, session 2	2158.08	1	1	12.5	0	1.00e+00	Retreg2
Locomotion distance, session 2	508.11	1	1	12.5	0	1.00e+00	Retreg2
Locomotion velocity, session 3	507.49	1	1	12.5	0	1.00e+00	Retreg2
Locomotion distance, session 3	4009.46	1	1	12.5	0	1.00e+00	Retreg2
Stereotopy head waving bouts, day 3	1361.96	1	1	12.5	0	1.00e+00	Retreg2
Stereotopy head waving duration, day 3	2872.44	1	1	12.5	0	1.00e+00	Retreg2
Locomotion velocity, session 7	292.79	1	1	12.5	0	1.00e+00	Retreg2
Locomotion distance, session 7	856.72	1	1	12.5	0	1.00e+00	Retreg2
Stereotopy head waving bouts, day 7	2509.72	1	1	12.5	0	1.00e+00	Retreg2
Stereotopy head waving duration, day 7	2115.93	1	1	12.5	0	1.00e+00	Retreg2
Locomotion velocity, session 8	409.23	1	1	12.5	0	1.00e+00	Retreg2
Locomotion distance, session 8	147.88	1	1	12.5	0	1.00e+00	Retreg2
Degree of sensitization distance	3670.85	1	1	12.5	0	1.00e+00	Retreg2
Degree of sensitization stereotypy	2042.98	1	1	12.5	0	1.00e+00	Retreg2
Condit. Reinf. active minus inactive responses	957.65	1	1	12.5	0	1.00e+00	Retreg2
Condit. Reinf. active-inactive response ratio	242.03	1	1	12.5	0	1.00e+00	Retreg2
Condit. Reinf. active responses	2765.7	1	1	12.5	0	1.00e+00	Retreg2
Condit. Reinf. inactive responses	4681.39	1	1	12.5	0	1.00e+00	Retreg2
Incentive salience index mean	3540.72	1	1	12.5	0	1.00e+00	Retreg2
Condit. Reinf. lever presses	5282.33	1	1	12.5	0	1.00e+00	Retreg2
Time in familiar zone, hab. session 1	3730.21	2	1	12.5	0	1.00e+00	Retreg2 Zfp110
Time in novel zone, hab. session 1	4621.49	2	1	12.5	0	1.00e+00	Retreg2 Zfp110
Total zone transitions, hab. session 1	429.72	1	1	12.5	0	1.00e+00	Retreg2
Total locomotion distance, hab. session 1	394.1	1	1	12.5	0	1.00e+00	Retreg2
Locomotion velocity, hab. session 1	266.96	1	1	12.5	0	1.00e+00	Retreg2
Time in familiar zone, hab. session 2	5880.03	1	1	12.5	0	1.00e+00	Retreg2
Time in novel zone, hab. session 2	6311.49	1	1	12.5	0	1.00e+00	Retreg2
Total zone transitions, hab. session 2	26.56	2	1	12.5	0	1.00e+00	Retreg2 Zfp110
Total locomotion distance, hab. session 2	22.17	1	1	12.5	0	1.00e+00	Retreg2
Locomotion velocity, hab. session 2	31.27	1	1	12.5	0	1.00e+00	Retreg2
Novel to familiar place preference ratio	15339.58	1	1	12.5	0	1.00e+00	Retreg2
Novelty place preference	14927.56	1	1	12.5	0	1.00e+00	Retreg2
Time in novel zone, NPP test	10685.62	1	1	12.5	0	1.00e+00	Retreg2
Total zone transitions, NPP test	1935.62	1	1	12.5	0	1.00e+00	Retreg2
Total locomotion distance, NPP test	1687.31	1	1	12.5	0	1.00e+00	Retreg2
Locomotion velocity, NPP test	953.07	1	1	12.5	0	1.00e+00	Retreg2
Pavlov. Cond. lever latency	491.79	1	1	12.5	0	1.00e+00	Retreg2
Pavlov. Cond. change in total contacts	1037.76	1	1	12.5	0	1.00e+00	Retreg2
Pavlov. Cond. index score	384.43	1	1	12.5	0	1.00e+00	Retreg2
Pavlov. Cond. latency score	404.63	1	1	12.5	0	1.00e+00	Retreg2
Pavlov. Cond. lever contacts	677.08	1	1	12.5	0	1.00e+00	Retreg2
Pavlov. Cond. magazine entry number	491.61	1	1	12.5	0	1.00e+00	Retreg2
Pavlov. Cond. intertrial magazine entries	123.55	1	1	12.5	0	1.00e+00	Retreg2
Pavlov. Cond. lever-magazine prob. diff.	418.89	1	1	12.5	0	1.00e+00	Retreg2
Pavlov. Cond. response bias	583.93	1	1	12.5	0	1.00e+00	Retreg2
Bone: apparent density	5461.77	1	1	12.5	0	1.00e+00	Retreg2
Bone surface	6197.68	1	1	12.5	0	1.00e+00	Retreg2
Bone volume	8624.75	1	1	12.5	0	1.00e+00	Retreg2
Bone: connectivity density	1667.52	1	1	12.5	0	1.00e+00	Retreg2
Bone: cortical apparent density	12020.36	1	1	12.5	0	1.00e+00	Retreg2
Bone: cortical area	4581.96	1	1	12.5	0	1.00e+00	Retreg2
Bone: cortical porosity	432.96	1	1	12.5	0	1.00e+00	Retreg2
Bone: cortical porosity	1113.18	1	1	12.5	0	1.00e+00	Retreg2
Bone: cortical thickness	374.52	1	1	12.5	0	1.00e+00	Retreg2
Bone: cortical thickness	2918.77	1	1	12.5	0	1.00e+00	Retreg2
Bone: cortical tissue density	13002.58	1	1	12.5	0	1.00e+00	Retreg2
Bone: elastic displacement	7604.03	1	1	12.5	0	1.00e+00	Retreg2
Bone: elastic work	361.86	1	1	12.5	0	1.00e+00	Retreg2
Bone: endosteal estimation	8913.19	1	1	12.5	0	1.00e+00	Retreg2
Bone: endosteal perimeter	11863.6	1	1	12.5	0	1.00e+00	Retreg2
Bone: final force	1600.36	1	1	12.5	0	1.00e+00	Retreg2
Bone: final moment	219.15	1	1	12.5	0	1.00e+00	Retreg2
Bone: marrow area	9430.07	1	1	12.5	0	1.00e+00	Retreg2
Bone: maximum diameter	6068.73	1	1	12.5	0	1.00e+00	Retreg2
Bone: maximum force	8697.09	1	1	12.5	0	1.00e+00	Retreg2
Bone: maximum moment	5989.29	1	1	12.5	0	1.00e+00	Retreg2
Bone: minimum diameter	2053.04	2	1	12.5	0	1.00e+00	Retreg2 Zfp446
Bone: periosteal estimation	9791.57	1	1	12.5	0	1.00e+00	Retreg2
Bone: periosteal perimeter	11400.25	1	1	12.5	0	1.00e+00	Retreg2
Bone: post-yield work	13672.98	1	1	12.5	0	1.00e+00	Retreg2
Bone: stiffness	9032.86	1	1	12.5	0	1.00e+00	Retreg2
Bone: tissue strength	2995.95	1	1	12.5	0	1.00e+00	Retreg2
Bone: trabecular number	10739.78	1	1	12.5	0	1.00e+00	Retreg2
Bone: trabecular spacing	7952.12	1	1	12.5	0	1.00e+00	Retreg2
Bone: trabecular thickness	8476.26	1	1	12.5	0	1.00e+00	Retreg2
Bone: trabecular tissue density	14554.51	1	1	12.5	0	1.00e+00	Retreg2
Breakpoint value in progressive ratio session	37605.61	1	1	12.5	0	1.00e+00	Retreg2
Distance traveled before self-admin	4603.84	6	1	12.5	-0.89	2.11e-04	Retreg2 Zfp110 Zfp329 Zfp446 Zfp551 Zscan18
Distance traveled after self-admin	2176.69	7	1	12.5	-0.82	1.53e-04	Retreg2 Vom1r47 Vom2r36 Zfp110 Zfp329 Zfp551 Zscan18
Delta time in closed arm before/after self-admin	244.69	1	1	12.5	0	1.00e+00	Retreg2
Delta time in open arm before/after self-admin	15131.21	1	1	12.5	0	1.00e+00	Retreg2
Diff in mean of infusions in LGA sessions	36650	1	1	12.5	0	1.00e+00	Retreg2
Extinction: sum of active levers before priming	28373.8	1	1	12.5	0	1.00e+00	Retreg2
Active lever presses in extinction session 6	738.98	1	1	12.5	0	1.00e+00	Retreg2
Delta distance traveled before/after self-admin	2940.47	1	1	12.5	0	1.00e+00	Retreg2
Delta ambulatory time before/after self-admin	30849.75	1	1	12.5	0	1.00e+00	Retreg2
Time in closed arm before self-admin	26866.11	1	1	12.5	0	1.00e+00	Retreg2
Time in closed arm after self-admin	4591.18	1	1	12.5	0	1.00e+00	Retreg2
Time in open arm before self-admin	2195.63	4	1	12.5	0.99	1.16e-02	LOC120096890 Retreg2 Zfp110 Zfp329
Time in open arm after self-admin	244.22	2	1	12.5	0	1.00e+00	LOC120096890 Retreg2
Sum of active levers in priming session hrs 5-6	978.69	1	1	12.5	0	1.00e+00	Retreg2
Time to tail flick, vehicle, before self-admin	13364.89	1	1	12.5	0	1.00e+00	Retreg2
Time to tail flick, vehicle, after self-admin	42142.71	1	1	12.5	0	1.00e+00	Retreg2
Time to tail flick, test, before self-admin	750.2	6	1	12.5	0.94	2.15e-05	LOC120096890 Retreg2 Vom2r36 Zfp110 Zfp329 Zscan18
Time to tail flick, test, after self-admin	1399.18	1	1	12.5	0	1.00e+00	Retreg2
Delta time to tail flick, vehicle, before/after SA	9805.78	1	1	12.5	0	1.00e+00	Retreg2
Delta time to tail flick, test, before/after SA	7847.05	2	1	12.5	0	1.00e+00	Retreg2 Zscan18
Ambulatory time before self-admin	13152.2	4	1	12.5	-0.94	6.13e-03	Retreg2 Zfp110 Zfp446 Zscan18
Ambulatory time after self-admin	2430.5	5	1	12.5	-0.85	8.60e-04	Retreg2 Vom2r36 Zfp110 Zfp329 Zscan18
Total heroin consumption	240.55	1	1	12.5	0	1.00e+00	Retreg2
Area under the delay curve	24791.27	1	1	12.5	0	1.00e+00	Retreg2
Delay disc. indifference point, 0s delay	316.54	4	1	12.5	-0.85	1.58e-02	Retreg2 Zfp110 Zfp329 Zscan18
Delay disc. indifference point, 16s delay	7326.89	2	1	12.5	0	1.00e+00	Retreg2 Zscan18
Delay disc. indifference point, 2s delay	155.27	1	1	12.5	0	1.00e+00	Retreg2
Delay disc. indifference point, 24s delay	16222.95	2	1	12.5	0	1.00e+00	LOC120096890 Retreg2
Delay disc. indifference point, 4s delay	616.19	1	1	12.5	0	1.00e+00	Retreg2
Delay disc. indifference point, 8s delay	33362.4	1	1	12.5	0	1.00e+00	Retreg2
Delay discount exponential model param	16922.54	1	1	12.5	0	1.00e+00	Retreg2
Delay discount hyperbolic model param	12277.65	1	1	12.5	0	1.00e+00	Retreg2
Fecal boli incidents, locomotor time 1	61202.36	1	1	12.5	0	1.00e+00	Retreg2
Change in fecal boli incidents, locomotor task	5669.94	1	1	12.5	0	1.00e+00	Retreg2
Time >=10cm from walls, locomotor time 1	13009.3	1	1	12.5	0	1.00e+00	Retreg2
Bouts of movement, locomotor time 1	2702.95	3	1	12.5	-0.94	6.21e-02	Retreg2 Zfp110 Zfp329
Total resting periods, locomotor time 1	2793.59	1	1	12.5	0	1.00e+00	Retreg2
Rest time, locomotor task time 1	22349.64	1	1	12.5	0	1.00e+00	Retreg2
Distance moved, locomotor task time 1	68821.85	1	1	12.5	0	1.00e+00	Retreg2
Vertical activity count, locomotor time 1	23729.09	4	1	12.5	0.95	4.01e-03	Retreg2 Vom2r36 Zfp329 Zscan18
Time >=10cm from walls, locomotor time 2	71159.6	1	1	12.5	0	1.00e+00	Retreg2
Bouts of movement, locomotor time 2	82029.05	1	1	12.5	0	1.00e+00	Retreg2
Total resting periods, locomotor time 2	99042.67	1	1	12.5	0	1.00e+00	Retreg2
Rest time, locomotor task time 2	25503.09	1	1	12.5	0	1.00e+00	Retreg2
Distance moved, locomotor task time 2	8477.87	1	1	12.5	0	1.00e+00	Retreg2
Vertical activity count, locomotor time 2	53555.35	1	1	12.5	0	1.00e+00	Retreg2
Weight adjusted by age	70782.25	1	1	12.5	0	1.00e+00	Retreg2
Seeking ratio, delayed vs. immediate footshock	1131.23	6	1	12.5	-0.84	7.22e-04	LOC120096890 Retreg2 Vom2r36 Zfp110 Zfp329 Zscan18
Locomotion in novel chamber	3903.37	1	1	12.5	0	1.00e+00	Retreg2
Locomotion in novel chamber post-restriction	65422.89	1	1	12.5	0	1.00e+00	Retreg2
Progressive ratio	67888.93	1	1	12.5	0	1.00e+00	Retreg2
Seeking ratio, punishment vs. effort	41283.25	1	1	12.5	0	1.00e+00	Retreg2
Run reversals in cocaine runway, females	9406.04	1	1	12.5	0	1.00e+00	Retreg2
Run reversals in cocaine runway, males	7664.74	1	1	12.5	0	1.00e+00	Retreg2
Latency to leave start box in cocaine runway	16290.75	1	1	12.5	0	1.00e+00	Retreg2
Latency to leave start box in cocaine runway, F	7166.92	1	1	12.5	0	1.00e+00	Retreg2
Latency to leave start box in cocaine runway, M	1716.51	1	1	12.5	0	1.00e+00	Retreg2
Co content in liver	1133.25	1	1	12.5	0	1.00e+00	Retreg2
Cu content in liver	39.92	1	1	12.5	0	1.00e+00	Retreg2
Fe content in liver	1344.53	1	1	12.5	0	1.00e+00	Retreg2
K content in liver	1519.62	1	1	12.5	0	1.00e+00	Retreg2
Mg content in liver	6026.97	1	1	12.5	0	1.00e+00	Retreg2
Mn content in liver	1009.39	1	1	12.5	0	1.00e+00	Retreg2
Na content in liver	4018.36	1	1	12.5	0	1.00e+00	Retreg2
Rb content in liver	87.87	1	1	12.5	0	1.00e+00	Retreg2
Sr content in liver	13.5	5	0	0	0.99	3.70e-06	Vom1r47 Vom2r36 Zfp110 Zfp329 Zscan18
Zn content in liver	3745.55	1	1	12.5	0	1.00e+00	Retreg2

Associations by panel

Tissue	RNA modality	# hits	% hits/tests	Avg chisq
Adipose	alternative polyA	0	0	1.25
Adipose	alternative TSS	2	0.1	1.26
Adipose	gene expression	1	0	1.23
Adipose	isoform ratio	0	0	1.26
Adipose	intron excision ratio	0	0	1.13
Adipose	mRNA stability	0	0	1.21
BLA	alternative polyA	0	0	1.24
BLA	alternative TSS	0	0	1.21
BLA	gene expression	1	0	1.23
BLA	isoform ratio	0	0	1.2
BLA	intron excision ratio	0	0	1.07
BLA	mRNA stability	1	0	1.31
Brain	alternative polyA	0	0	1.28
Brain	alternative TSS	0	0	1.23
Brain	gene expression	2	0	1.23
Brain	isoform ratio	0	0	1.23
Brain	intron excision ratio	0	0	1.14
Brain	mRNA stability	0	0	1.26
Eye	alternative polyA	0	0	1.22
Eye	alternative TSS	0	0	1.26
Eye	gene expression	0	0	1.36
Eye	isoform ratio	0	0	1.27
Eye	intron excision ratio	0	0	1.2
Eye	mRNA stability	0	0	1.36
IC	alternative polyA	0	0	1.24
IC	alternative TSS	0	0	1.14
IC	gene expression	1	0	1.25
IC	isoform ratio	0	0	1.28
IC	intron excision ratio	0	0	1.11
IC	mRNA stability	0	0	1.26
IL	alternative polyA	0	0	1.28
IL	alternative TSS	0	0	1.11
IL	gene expression	0	0	1.22
IL	isoform ratio	0	0	1.21
IL	intron excision ratio	0	0	0.98
IL	mRNA stability	0	0	1.27
LHb	alternative polyA	0	0	1.18
LHb	alternative TSS	0	0	1.13
LHb	gene expression	0	0	1.17
LHb	isoform ratio	0	0	1.33
LHb	intron excision ratio	0	0	1.05
LHb	mRNA stability	0	0	1.29
Liver	alternative polyA	0	0	1.25
Liver	alternative TSS	0	0	1.3
Liver	gene expression	1	0	1.2
Liver	isoform ratio	0	0	1.23
Liver	intron excision ratio	0	0	1.1
Liver	mRNA stability	0	0	1.24
NAcc	alternative polyA	1	0	1.94
NAcc	alternative TSS	2	0.1	1.36
NAcc	gene expression	2	0	1.25
NAcc	isoform ratio	0	0	1.22
NAcc	intron excision ratio	0	0	1.16
NAcc	mRNA stability	1	0	1.29
OFC	alternative polyA	0	0	1.22
OFC	alternative TSS	0	0	1
OFC	gene expression	0	0	1.2
OFC	isoform ratio	0	0	1.19
OFC	intron excision ratio	0	0	1
OFC	mRNA stability	0	0	1.24
PL	alternative polyA	0	0	1.27
PL	alternative TSS	0	0	1.25
PL	gene expression	1	0	1.21
PL	isoform ratio	0	0	1.26
PL	intron excision ratio	0	0	1.11
PL	mRNA stability	1	0	1.28
pVTA	alternative polyA	0	0	1.23
pVTA	alternative TSS	0	0	1.25
pVTA	gene expression	3	0	1.25
pVTA	isoform ratio	0	0	1.3
pVTA	intron excision ratio	0	0	1.12
pVTA	mRNA stability	0	0	1.26
RMTg	alternative polyA	0	0	1.04
RMTg	alternative TSS	0	0	1.21
RMTg	gene expression	0	0	1.21
RMTg	isoform ratio	0	0	1.26
RMTg	intron excision ratio	0	0	1.12
RMTg	mRNA stability	0	0	1.33