Hub : Genes

Gba2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Brain alternative TSS NM_001013091.2 0.04 0.04 9.2e-03 0.02 0.01 0.01 0.02 3.7e-03 2.7e-02 2.3e-02 8.0e-03
2 Eye gene expression Gba2 0.76 0.13 2.8e-03 0.03 0.04 0.04 0.06 1.0e-01 7.7e-02 7.6e-02 4.4e-02
3 NAcc gene expression Gba2 0.05 0.04 2.9e-05 0.03 0.03 0.03 0.03 6.9e-05 1.2e-04 1.2e-04 8.6e-05
4 OFC alternative TSS NM_001013091.2 0.48 0.18 4.3e-03 0.01 0.05 0.04 0.03 1.4e-01 2.2e-02 3.1e-02 8.5e-02
5 OFC alternative TSS NM_001013091.2 0.41 0.19 7.7e-03 0.03 0.04 0 0.03 8.0e-02 4.6e-02 2.8e-01 6.5e-02
6 IL gene expression Gba2 0.19 0.12 2.1e-03 0.09 0.09 0.12 0.03 4.1e-03 3.1e-03 7.2e-04 6.7e-02
7 IL alternative TSS XM_039109585.1 0.25 0.15 8.9e-03 0.1 0.03 0.03 0.07 2.1e-03 8.4e-02 7.5e-02 7.2e-03
8 PL gene expression Gba2 0.09 0.05 3.3e-08 0.03 0.07 0.07 0.07 7.4e-04 1.1e-08 4.5e-08 2.3e-08
9 Brain gene expression Gba2 0.1 0.06 3.2e-07 0.06 0.06 0.07 0.06 6.3e-06 1.4e-06 1.0e-06 3.6e-06

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9
Bone: apparent density0.91.42.51.5-1.11.6-0.7-0.61.50.5-1.11.5
Area under the delay curve0.60.61.4-0.50.1-1.0-0.2-0.2-1.2-0.81.0-1.2
BMI with tail1.65.29.82.6-1.93.1-1.3-1.32.90.8-2.23.1
BMI without tail3.06.215.84.0-3.63.6-1.3-1.42.1-0.8-1.31.9
Body weight1.98.017.34.2-3.63.8-2.2-2.22.7-0.7-1.62.7
Weight adjusted by age1.01.12.50.6-0.9-0.1-1.6-1.6-0.6-1.51.1-0.5
Bone surface0.50.81.91.4-1.31.0-1.0-1.00.6-0.5-0.10.6
Bone volume0.40.81.61.3-1.01.2-0.7-0.70.90.0-0.50.9
Breakpoint value in progressive ratio session2.02.23.8-0.1-0.6-1.2-1.6-1.6-1.7-1.91.9-1.6
Number of licking bursts2.63.06.62.4-1.82.6-0.3-0.42.10.4-1.62.0
Context. condit. distance diff. score0.10.10.3-0.40.5-0.3-0.2-0.10.10.5-0.20.3
Locomotion velocity, session 14.85.211.41.1-2.2-0.4-2.6-2.7-1.9-3.42.6-1.9
Locomotion distance, session 11.11.43.30.8-1.50.0-1.1-1.2-1.0-1.81.3-1.1
Locomotion velocity, session 21.41.63.11.7-1.01.8-0.1-0.11.70.5-1.41.6
Locomotion distance, session 21.11.55.02.0-2.21.4-0.1-0.30.1-1.50.3-0.5
Locomotion velocity, session 30.91.12.20.4-1.0-0.4-1.0-1.1-1.1-1.51.3-1.1
Locomotion distance, session 32.12.24.61.8-2.01.3-2.1-2.10.5-1.20.20.7
Stereotopy head waving bouts, day 31.11.33.1-0.2-0.5-0.8-0.5-0.6-1.5-1.81.6-1.6
Stereotopy head waving duration, day 30.60.71.7-0.60.1-0.9-0.1-0.1-1.2-1.01.2-1.3
Locomotion velocity, session 70.00.00.1-0.30.2-0.30.00.0-0.20.10.1-0.1
Locomotion distance, session 70.20.20.50.7-0.70.4-0.7-0.70.1-0.40.10.1
Stereotopy head waving bouts, day 71.51.72.81.6-1.71.4-1.6-1.60.8-1.0-0.10.9
Stereotopy head waving duration, day 70.30.41.10.9-1.00.7-0.5-0.60.0-0.90.3-0.0
Locomotion velocity, session 80.70.82.20.4-0.8-0.30.40.3-1.1-1.31.1-1.5
Locomotion distance, session 80.40.61.40.7-1.00.1-0.4-0.5-0.6-1.20.8-0.8
Degree of sensitization distance1.01.12.4-1.11.1-1.01.51.5-0.60.60.1-0.8
Degree of sensitization stereotypy1.01.12.01.2-1.11.2-1.4-1.40.8-0.6-0.31.1
Conditioned locomotion1.21.42.9-0.0-0.5-0.6-1.7-1.7-1.0-1.61.3-0.7
Cocaine response after cond. corrected2.32.65.2-1.10.2-1.9-0.9-0.9-2.3-1.42.2-2.1
Cocaine response after cond. not corrected2.52.76.1-0.9-0.1-1.7-0.4-0.5-2.4-1.72.3-2.5
Cocaine response before conditioning0.50.61.31.1-0.91.20.80.70.70.0-0.60.4
Saline control response1.01.23.11.3-1.80.7-1.0-1.1-0.4-1.60.9-0.5
Bone: connectivity density0.60.91.90.9-0.51.1-0.6-0.51.30.7-1.01.4
Bone: cortical apparent density1.11.43.4-0.51.10.41.21.31.11.8-1.41.2
Bone: cortical area1.52.24.71.9-1.22.20.30.21.90.6-1.61.8
Bone: cortical porosity0.20.20.6-0.70.7-0.80.20.2-0.40.00.3-0.4
Bone: cortical porosity0.00.00.2-0.10.1-0.1-0.4-0.40.1-0.20.10.1
Bone: cortical thickness1.11.74.00.9-0.21.50.20.31.91.3-1.72.0
Bone: cortical thickness0.20.30.7-0.40.60.00.80.80.20.5-0.40.1
Bone: cortical tissue density0.91.23.0-0.61.10.31.21.21.01.7-1.31.0
Condit. Reinf. active minus inactive responses0.30.40.70.7-0.50.80.40.30.80.2-0.70.6
Condit. Reinf. active-inactive response ratio0.40.41.0-1.00.9-0.60.70.7-0.20.40.0-0.2
Condit. Reinf. active responses1.51.84.11.8-1.32.00.20.21.80.3-1.41.4
Condit. Reinf. inactive responses2.12.45.41.9-1.32.30.60.62.00.7-1.81.7
Incentive salience index mean2.02.45.92.4-2.12.2-0.5-0.61.7-0.3-1.11.3
Condit. Reinf. lever presses4.96.517.04.1-3.93.4-1.7-1.82.0-1.2-1.01.7
Condit. Reinf. active minus inactive responses0.50.61.21.1-0.81.0-0.2-0.20.90.5-0.70.9
Condit. Reinf. active-inactive response ratio0.30.30.80.4-0.00.5-0.1-0.10.80.8-0.70.9
Condit. Reinf. active responses1.31.74.42.1-1.71.9-0.4-0.41.40.2-1.01.2
Condit. Reinf. inactive responses1.72.14.82.0-1.52.20.20.21.80.5-1.41.5
Condit. Reinf. lever presses1.92.64.61.7-1.02.20.50.52.11.3-2.01.9
Condit. Reinf. lever reinforcers received1.42.05.12.3-1.82.1-0.3-0.41.50.3-1.11.3
Conditioned reinforcement - actives0.40.40.90.3-0.10.3-1.0-0.90.60.3-0.40.9
Conditioned reinforcement - inactives0.10.10.4-0.30.1-0.4-0.6-0.6-0.3-0.00.3-0.1
Conditioned locomotion0.60.72.40.5-0.50.4-1.5-1.40.50.2-0.30.9
Patch foraging indifference point 0 sec3.35.314.71.0-1.9-0.4-3.8-3.8-1.3-2.72.1-0.7
Patch foraging indifference point AUC4.34.912.33.5-3.13.0-1.3-1.42.0-0.9-1.21.7
Delay disc. indifference point, 0s delay1.01.12.2-1.10.6-1.50.10.0-1.4-0.71.2-1.5
Delay disc. indifference point, 16s delay2.02.13.9-0.70.0-1.6-1.1-1.1-1.9-1.52.0-1.8
Delay disc. indifference point, 2s delay0.20.20.4-0.00.30.30.30.40.50.6-0.60.5
Delay disc. indifference point, 24s delay0.10.10.3-0.40.3-0.30.60.5-0.30.00.2-0.4
Delay disc. indifference point, 4s delay0.10.10.1-0.30.2-0.30.10.1-0.3-0.10.2-0.4
Delay disc. indifference point, 8s delay0.00.00.10.1-0.20.00.30.2-0.1-0.20.0-0.3
Indifference point function ln k1.41.94.5-2.11.8-2.00.40.4-1.5-0.01.1-1.3
Indifference point function log k1.41.94.5-2.11.8-2.00.40.4-1.5-0.01.1-1.3
Patch foraging total patch changes 0 sec3.25.115.11.3-2.10.0-3.9-3.8-0.8-2.51.8-0.3
Patch foraging total patch changes 12 sec1.92.54.21.8-1.71.7-2.1-2.01.4-0.6-0.71.6
Patch foraging total patch changes 18 sec0.60.81.81.3-1.30.8-1.0-1.00.3-0.70.10.3
Patch foraging total patch changes 24 sec2.32.85.32.1-2.21.4-2.3-2.30.8-1.20.00.9
Patch foraging total patch changes 6 sec3.24.811.22.4-2.71.4-3.3-3.30.4-2.20.60.7
Patch foraging time to switch 0 sec2.23.47.0-2.62.6-1.92.12.2-0.81.5-0.0-0.8
Patch foraging water rate 0 sec2.64.211.12.0-2.31.3-3.3-3.30.4-1.80.60.9
Patch foraging water rate 12 sec0.30.41.00.3-0.60.1-1.0-1.0-0.5-0.90.7-0.3
Patch foraging water rate 18 sec0.60.81.90.5-0.30.8-1.2-1.11.00.4-0.71.4
Patch foraging water rate 24 sec0.50.71.7-0.20.60.60.00.11.11.1-1.11.3
Patch foraging water rate 6 sec0.30.51.21.1-1.00.9-0.6-0.60.5-0.5-0.10.4
Seeking ratio, delayed vs. immediate footshock2.12.44.31.9-1.52.1-1.2-1.11.80.2-1.41.9
Distance traveled before self-admin2.52.76.82.6-2.61.8-1.4-1.50.7-1.40.10.5
Distance traveled after self-admin0.60.71.40.7-0.30.91.21.10.90.5-0.90.5
Extensor digitorum longus weight2.59.723.34.8-4.14.2-2.1-2.22.9-1.1-1.62.8
Bone: elastic displacement2.12.37.2-2.62.7-1.90.80.9-0.71.20.1-0.2
Bone: elastic work2.43.17.0-1.92.6-0.71.61.70.92.6-1.51.2
Bone: endosteal estimation0.51.23.61.8-1.91.2-0.3-0.50.2-1.30.2-0.1
Bone: endosteal perimeter0.71.54.41.8-2.11.1-0.9-1.0-0.1-1.60.5-0.2
Epididymis fat weight0.20.51.71.2-1.31.00.10.00.3-0.8-0.0-0.1
Delta time in closed arm before/after self-admin2.32.24.21.4-0.72.00.60.62.01.2-1.91.9
Delta time in open arm before/after self-admin0.60.61.2-0.60.1-1.0-0.3-0.3-1.1-0.71.1-1.1
Diff in mean of infusions in LGA sessions0.10.10.3-0.30.3-0.00.60.60.10.3-0.2-0.0
Delay discount exponential model param0.50.51.10.4-0.00.90.30.31.00.8-1.01.1
Extinction: sum of active levers before priming1.21.22.3-1.51.2-1.40.70.7-1.2-0.20.8-1.2
Active lever presses in extinction session 60.40.40.6-0.60.3-0.8-0.8-0.7-0.6-0.50.7-0.4
Bone: final force0.71.13.01.7-1.31.60.70.61.00.2-0.80.6
Bone: final moment0.61.02.11.5-1.01.50.90.81.00.5-0.90.6
Food consumed during 24 hour testing period0.40.51.61.2-1.30.9-0.1-0.20.2-0.80.1-0.0
Glucose0.71.02.31.5-1.41.3-0.8-0.80.8-0.5-0.40.8
Heart weight0.40.51.51.2-1.20.9-0.5-0.60.1-0.60.10.1
Delay discount hyperbolic model param0.40.51.00.4-0.00.80.30.31.00.7-0.91.0
Intermittent access intake day 1-15 change1.41.42.70.40.21.20.90.91.51.5-1.61.5
Intermittent access intake escalation1.41.32.60.8-0.21.40.50.51.61.2-1.61.6
Intermittent access intake escalation 22.32.34.40.60.11.60.80.82.01.9-2.12.1
Intermitt. access day 1 inactive lever presses0.40.40.80.9-0.80.7-0.7-0.70.6-0.2-0.30.6
Intermitt. access day 15 inactive lever presses0.50.51.20.1-0.3-0.3-1.1-1.1-0.5-1.00.7-0.4
Intermitt. access escalation Index0.90.82.31.4-1.50.7-0.8-0.90.0-0.80.4-0.0
Intermittent access day 1 total infusions1.61.84.9-0.4-0.1-1.1-2.2-2.1-1.2-1.21.4-0.7
Intermittent access day 15 total infusions0.70.72.20.6-0.50.6-1.5-1.40.60.2-0.41.0
Intermittent access terminal intake (last 3 days)0.91.03.10.7-0.70.6-1.8-1.70.70.1-0.31.1
Intermittent access total infusions1.31.55.20.9-1.00.6-2.3-2.20.5-0.4-0.01.0
Intermittent access day 1 locomotion1.31.43.6-0.70.3-1.3-1.9-1.8-1.2-0.61.2-0.6
Intermittent access day 15 total locomotion0.80.92.5-1.00.7-1.0-1.6-1.4-0.6-0.00.6-0.0
Intermittent access total locomotion0.60.61.8-0.90.9-0.7-1.3-1.2-0.00.5-0.00.5
Intermittent access standard deviation0.30.30.90.3-0.10.8-0.2-0.20.80.4-0.70.9
Left kidney weight0.51.33.01.5-1.70.7-1.4-1.5-0.1-1.30.6-0.1
Right kidney weight0.10.30.90.4-0.7-0.10.10.0-0.7-0.70.7-1.0
Cocaine induced anxiety0.70.81.5-1.20.9-1.20.40.4-1.0-0.20.8-1.0
Post-drug Anxiety0.30.40.70.8-0.80.50.80.7-0.0-0.50.1-0.5
Baseline Anxiety1.31.42.71.3-0.81.60.90.81.40.8-1.41.1
Tail length1.23.711.83.4-3.22.8-0.2-0.41.1-1.3-0.50.5
Length with tail0.51.85.32.2-2.31.4-0.9-1.00.2-1.60.4-0.2
Length without tail0.30.61.5-1.00.7-1.2-0.6-0.5-0.8-0.30.8-0.7
Times rat made contact with spout0.50.51.50.5-0.10.7-0.3-0.21.00.8-0.91.2
Lifetime Intake2.02.38.21.0-1.40.2-2.9-2.8-0.2-1.00.70.3
Liver weight, left0.50.82.31.0-0.91.01.51.40.3-0.2-0.3-0.4
Liver weight, right0.20.30.8-0.0-0.1-0.30.70.6-0.7-0.70.6-0.9
Locomotor activity0.00.00.00.1-0.10.10.20.2-0.0-0.10.0-0.1
Locomotor testing distance0.40.71.60.1-0.5-0.5-0.2-0.3-1.0-1.21.1-1.3
Locomotor testing rearing0.30.51.71.3-1.30.80.0-0.10.1-0.60.2-0.3
Locomotion in novel chamber0.50.61.9-0.20.60.20.40.50.81.4-1.01.0
Locomotion in novel chamber post-restriction2.32.85.21.2-0.42.01.11.12.21.7-2.32.1
Fecal boli incidents, locomotor time 10.40.51.3-1.11.1-0.70.70.7-0.20.6-0.2-0.1
Change in fecal boli incidents, locomotor task1.31.22.61.3-1.60.6-1.6-1.6-0.0-1.00.60.0
Time >=10cm from walls, locomotor time 10.70.71.40.3-0.7-0.3-1.1-1.1-0.7-1.21.0-0.7
Bouts of movement, locomotor time 11.01.12.5-1.61.5-1.40.90.9-0.90.20.5-0.9
Total resting periods, locomotor time 11.51.63.6-1.91.9-1.41.41.4-0.70.70.1-0.7
Rest time, locomotor task time 13.74.18.8-1.72.5-0.42.93.00.82.4-1.70.6
Distance moved, locomotor task time 12.52.75.41.9-2.30.8-2.3-2.3-0.2-1.81.0-0.2
Vertical activity count, locomotor time 12.42.64.81.6-2.20.3-1.8-1.9-0.9-2.11.6-1.0
Time >=10cm from walls, locomotor time 20.10.10.20.4-0.40.2-0.0-0.1-0.1-0.50.2-0.2
Bouts of movement, locomotor time 20.20.30.70.8-0.70.7-0.2-0.20.5-0.4-0.30.4
Total resting periods, locomotor time 20.10.10.20.5-0.30.4-0.2-0.20.4-0.2-0.30.4
Rest time, locomotor task time 20.50.51.4-1.11.2-0.90.70.7-0.20.5-0.1-0.2
Distance moved, locomotor task time 20.60.71.30.6-0.21.01.11.10.90.9-1.00.6
Vertical activity count, locomotor time 20.30.30.91.0-0.90.70.40.30.1-0.10.0-0.2
Light reinforcement 12.34.110.11.8-2.70.3-1.4-1.6-1.6-3.22.3-2.0
Light reinforcement 23.74.911.31.2-2.3-0.5-1.8-2.0-2.2-3.42.8-2.5
Bone: marrow area0.51.13.41.9-1.81.3-0.2-0.40.4-1.1-0.00.1
Bone: maximum diameter1.12.05.02.2-1.82.10.1-0.01.5-0.2-1.11.2
Bone: maximum force1.52.66.42.5-2.02.50.60.41.80.4-1.41.3
Bone: maximum moment1.32.25.02.2-1.52.20.80.71.70.6-1.51.3
Mean time between licks in bursts1.01.44.8-0.70.7-0.62.22.1-0.70.40.1-1.2
Mean num. licks in bursts1.11.33.2-1.81.6-1.70.40.4-1.10.30.7-0.9
Cd content in liver1.01.01.60.9-0.51.31.11.01.10.9-1.20.9
Co content in liver0.91.12.3-1.00.6-1.40.20.2-1.4-0.61.3-1.5
Cu content in liver1.21.43.7-1.31.4-0.61.91.9-0.20.9-0.3-0.5
Fe content in liver1.41.73.70.7-1.4-0.5-0.3-0.5-1.5-1.81.7-1.9
K content in liver0.50.41.1-0.3-0.0-0.8-0.2-0.2-0.9-0.70.9-1.0
Mg content in liver0.30.31.0-0.70.6-1.0-0.4-0.3-0.6-0.10.6-0.5
Mn content in liver0.50.51.10.20.10.60.60.60.91.0-1.10.8
Na content in liver1.71.74.2-1.31.0-1.12.01.9-1.10.30.5-1.5
Rb content in liver2.12.65.8-2.31.8-2.40.60.6-1.90.11.4-1.7
Se content in liver1.31.63.01.3-0.81.71.31.21.40.8-1.51.0
Sr content in liver0.30.20.50.7-0.50.60.30.30.50.2-0.60.3
Zn content in liver0.60.61.30.10.30.50.60.61.11.1-1.10.9
Bone: minimum diameter0.10.10.2-0.10.4-0.00.50.50.20.4-0.40.2
Time in familiar zone, hab. session 12.72.66.7-1.01.70.30.81.01.72.6-2.02.0
Time in novel zone, hab. session 14.14.010.5-0.7-0.2-1.90.30.1-2.9-2.32.7-3.2
Total zone transitions, hab. session 10.00.10.20.1-0.10.10.50.50.10.1-0.2-0.1
Total locomotion distance, hab. session 11.01.52.70.50.21.11.21.21.51.4-1.61.3
Locomotion velocity, hab. session 11.42.03.71.4-0.71.90.80.81.91.1-1.81.6
Time in familiar zone, hab. session 21.51.53.2-1.21.5-0.31.51.60.71.8-1.10.7
Time in novel zone, hab. session 22.52.54.8-0.70.0-1.6-1.0-1.0-2.2-1.82.2-2.0
Total zone transitions, hab. session 20.40.51.61.0-1.30.5-0.5-0.6-0.1-0.90.4-0.4
Total locomotion distance, hab. session 20.40.51.11.1-0.91.1-0.0-0.10.80.0-0.60.6
Locomotion velocity, hab. session 20.50.71.61.2-1.01.3-0.1-0.11.00.1-0.80.8
Novel to familiar place preference ratio2.93.05.8-1.61.0-2.4-0.4-0.4-2.4-1.42.2-2.3
Novelty place preference3.43.47.2-2.01.4-2.7-0.3-0.3-2.5-1.22.2-2.3
Time in novel zone, NPP test4.14.28.7-2.21.5-2.9-0.1-0.1-2.8-1.32.4-2.6
Total zone transitions, NPP test0.60.82.41.2-1.60.6-0.5-0.6-0.3-1.30.6-0.6
Total locomotion distance, NPP test1.21.64.01.8-2.01.2-1.3-1.40.4-1.20.20.3
Locomotion velocity, NPP test1.42.04.32.1-2.11.6-1.4-1.50.9-1.0-0.20.8
Intraocular pressure1.72.44.72.1-2.21.4-1.9-2.00.6-1.30.10.7
Delta distance traveled before/after self-admin1.01.13.0-1.01.1-0.71.71.7-0.30.8-0.2-0.5
Delta ambulatory time before/after self-admin1.82.04.7-1.71.6-1.22.22.1-0.60.9-0.0-0.8
Parametrial fat weight0.10.30.80.7-0.90.5-0.1-0.2-0.2-0.80.4-0.4
Pavlov. Cond. lever latency3.64.611.8-3.43.1-3.01.21.3-1.80.71.0-1.6
Pavlov. Cond. magazine entry latency0.30.40.60.7-0.50.80.60.50.70.4-0.70.4
Pavlov. Cond. change in total contacts1.31.43.41.8-1.71.6-0.7-0.71.0-0.4-0.50.9
Pavlov. Cond. index score1.52.04.72.2-1.82.10.1-0.01.50.2-1.21.2
Pavlov. Cond. latency score1.41.84.42.1-1.82.0-0.1-0.21.40.1-1.11.2
Pavlov. Cond. lever contacts2.83.27.62.7-2.42.5-1.1-1.21.7-0.3-1.11.7
Pavlov. Cond. magazine entry number0.40.51.3-1.00.8-1.1-0.4-0.3-0.8-0.20.7-0.6
Pavlov. Cond. intertrial magazine entries0.10.10.30.5-0.30.50.20.20.50.0-0.40.3
Pavlov. Cond. lever-magazine prob. diff.1.62.04.32.0-1.52.10.20.21.70.5-1.41.4
Pavlov. Cond. response bias1.51.84.32.1-1.82.0-0.3-0.41.4-0.1-1.01.2
Pavlov. Cond. lever latency2.12.85.2-1.81.0-2.3-0.7-0.7-2.3-1.22.1-2.0
Pavlov. Cond. magazine entry latency0.80.92.9-0.70.8-0.41.71.7-0.20.7-0.2-0.6
Pavlov. Cond. change in total contacts2.02.84.80.70.11.61.91.82.02.1-2.21.6
Pavlov. Cond. index score1.01.32.40.30.20.91.61.51.21.4-1.40.9
Pavlov. Cond. latency score1.21.52.60.40.21.11.41.41.41.6-1.61.2
Pavlov. Cond. lever contacts1.01.42.61.3-0.81.60.50.51.60.8-1.41.3
Pavlov. Cond. magazine entry number1.31.63.40.1-0.7-0.7-1.8-1.8-1.1-1.71.5-0.9
Pavlov. Cond. intertrial magazine entries0.40.61.50.8-0.80.6-1.2-1.20.4-0.3-0.00.6
Pavlov. Cond. lever-magazine prob. diff.1.21.52.80.30.30.91.71.71.21.6-1.50.9
Pavlov. Cond. response bias0.81.11.80.8-0.31.21.11.11.21.0-1.30.9
Time in closed arm before self-admin1.11.23.3-1.81.5-1.7-0.3-0.2-1.10.20.8-0.8
Time in closed arm after self-admin0.30.30.8-0.50.70.00.40.40.40.9-0.60.5
Time in open arm before self-admin1.41.54.42.0-2.11.2-1.0-1.10.3-1.20.30.1
Time in open arm after self-admin1.21.32.81.4-1.70.7-1.6-1.6-0.0-1.30.60.0
Bone: periosteal estimation0.71.54.42.1-1.81.80.1-0.01.0-0.6-0.70.7
Bone: periosteal perimeter0.40.71.71.2-1.30.7-0.5-0.6-0.1-1.20.4-0.2
Bone: post-yield work0.71.03.11.7-1.81.1-0.1-0.30.3-1.00.1-0.2
Progressive ratio test 1 active lever presses2.42.510.00.4-0.9-0.3-3.2-3.0-0.5-1.01.00.2
Progressive ratio test 1 breakpoint2.32.49.30.6-1.0-0.1-3.1-2.9-0.4-1.00.90.3
Progressive ratio test 1 inactive lever presses2.62.87.10.9-1.6-0.4-2.7-2.7-1.1-1.81.7-0.8
Progressive ratio test 2 active lever presses1.71.85.90.1-0.7-0.7-2.4-2.3-1.0-1.01.3-0.4
Progressive ratio test 2 breakpoint1.61.85.8-0.2-0.5-0.9-2.4-2.3-1.1-1.01.3-0.5
Progressive ratio test 2 inactive lever presses0.40.51.90.4-0.60.1-1.4-1.30.0-0.30.20.3
Incentive Sensitization - Responses0.40.40.9-0.1-0.3-0.5-0.9-0.9-0.6-0.70.8-0.5
Incentive Sensitization - Breakpoint0.40.40.9-0.2-0.1-0.6-0.9-0.9-0.7-0.70.8-0.5
Sum of active levers in priming session hrs 5-62.42.35.1-1.71.1-2.3-0.7-0.6-2.0-0.91.8-1.7
Progressive ratio0.00.00.1-0.1-0.1-0.2-0.1-0.1-0.3-0.10.2-0.3
Food seeking constrained by brief footshock5.36.513.63.6-3.72.3-3.2-3.30.9-2.10.31.1
Seeking ratio, punishment vs. effort1.21.53.11.7-1.71.3-1.4-1.40.8-0.8-0.10.8
Retroperitoneal fat weight0.10.40.8-0.80.8-0.40.90.9-0.10.4-0.2-0.2
Reaction time number correct0.30.41.10.6-0.80.2-1.1-1.1-0.3-0.60.5-0.1
Reaction time mean minus median2.93.96.90.30.81.52.12.22.32.6-2.62.0
Reaction time mean minus median AUC2.22.85.20.9-0.01.81.51.52.11.9-2.31.9
Reaction time num false alarms0.30.40.9-0.00.40.30.80.80.70.9-0.80.5
Reaction time num false alarms AUC0.20.20.40.6-0.40.60.10.10.70.4-0.60.5
Reaction time trials correct on left0.30.41.10.6-0.80.2-1.1-1.1-0.3-0.60.5-0.1
Reaction time trials on left0.30.40.90.5-0.70.1-1.0-1.0-0.3-0.60.6-0.2
Reaction time mean2.63.69.1-1.52.2-0.43.03.00.62.1-1.40.3
Reaction time mean AUC2.83.89.1-1.72.3-0.53.03.00.62.2-1.40.3
Median of all reaction times2.53.47.7-2.12.4-1.32.82.8-0.41.5-0.4-0.7
Reaction time omissions1.11.52.7-1.61.7-1.31.51.5-0.80.30.3-0.9
Reaction time false alarm rate0.30.40.7-0.30.6-0.00.80.80.50.8-0.70.3
Reaction time premature initiation rate1.41.85.9-2.42.4-1.60.50.6-0.21.3-0.20.1
Reaction time premature initiations0.71.03.5-1.91.7-1.3-0.1-0.0-0.30.80.10.1
Std. dev. reaction times2.63.68.0-0.61.50.72.82.81.62.3-2.11.2
Reaction time trials completed0.30.40.90.5-0.70.1-1.0-1.0-0.3-0.60.6-0.2
Reaction time trials AUC0.20.30.90.5-0.60.1-0.9-0.9-0.3-0.50.5-0.1
Run reversals in cocaine runway, females0.70.71.60.20.20.70.80.80.91.3-1.10.9
Run reversals in cocaine runway, males0.00.00.1-0.30.3-0.1-0.2-0.20.10.2-0.10.3
Latency to leave start box in cocaine runway0.50.51.10.7-0.51.0-0.2-0.21.00.3-0.81.0
Latency to leave start box in cocaine runway, F0.00.10.2-0.1-0.0-0.1-0.4-0.4-0.1-0.20.2-0.0
Latency to leave start box in cocaine runway, M0.80.72.01.4-1.41.0-0.7-0.80.4-0.6-0.00.3
Std. dev. time between licks in bursts0.30.41.0-0.70.6-0.61.01.0-0.50.20.1-0.7
Total sessions with >9 infusions2.52.76.80.2-1.0-1.0-2.6-2.6-1.4-1.71.8-1.0
Short access day 1 total inactive lever presses2.02.26.41.6-1.70.8-2.5-2.50.4-0.70.20.8
Short access day 10 total inactive lever presses0.10.10.30.4-0.30.50.20.10.3-0.1-0.20.2
Short access day 1 total infusions2.93.18.81.3-1.9-0.0-3.0-2.9-0.8-1.61.4-0.4
Short access day 10 total infusions2.12.37.20.9-1.5-0.0-2.7-2.6-0.6-1.31.1-0.2
Short access total infusions2.42.77.50.6-1.3-0.5-2.7-2.7-1.1-1.51.6-0.7
Short access day 1 locomotion0.70.82.0-0.2-0.3-1.0-1.4-1.4-0.9-0.10.9-0.5
Short access day 10 total locomotion0.40.51.4-1.01.2-0.70.30.40.11.0-0.40.2
Short access total locomotion0.60.61.90.3-0.7-0.3-1.4-1.4-0.5-0.40.7-0.3
One hour access (0.3 mA shock)1.11.24.01.0-1.20.4-2.0-2.0-0.0-0.80.50.3
Compulsive drug intake0.20.20.60.8-0.60.5-0.2-0.20.3-0.2-0.20.3
One hour access (shock baseline)1.51.76.40.6-1.00.0-2.5-2.4-0.3-1.00.80.2
Social response proportion2.62.87.3-1.81.9-1.12.72.7-0.51.4-0.2-0.9
Social responses0.30.40.90.8-0.80.90.70.60.70.2-0.60.3
Social time1.01.45.2-0.20.2-0.32.32.1-0.7-0.10.3-1.4
Soleus weight1.33.99.50.5-1.4-1.0-0.5-0.7-2.5-3.12.7-2.9
Bone: stiffness2.13.38.02.8-2.32.71.21.01.80.3-1.51.0
Tibialis anterior weight3.612.232.55.7-5.34.6-2.3-2.52.5-2.2-0.92.1
Time to tail flick, vehicle, before self-admin0.50.51.7-1.31.1-0.9-0.1-0.0-0.60.20.3-0.3
Time to tail flick, vehicle, after self-admin0.10.10.4-0.10.0-0.3-0.6-0.6-0.2-0.30.30.0
Time to tail flick, test, before self-admin0.30.30.60.5-0.20.7-0.3-0.20.80.3-0.70.8
Time to tail flick, test, after self-admin1.11.12.70.6-0.21.3-0.2-0.11.51.0-1.41.6
Delta time to tail flick, vehicle, before/after SA0.10.10.20.5-0.30.20.30.20.2-0.1-0.20.0
Delta time to tail flick, test, before/after SA0.10.10.1-0.40.3-0.1-0.00.00.10.4-0.20.3
Tibia length0.61.64.40.6-1.1-0.40.60.4-1.6-1.71.6-2.1
Ambulatory time before self-admin2.62.75.92.3-2.41.4-1.9-2.00.3-1.70.50.2
Ambulatory time after self-admin0.10.10.20.5-0.40.20.40.30.0-0.40.1-0.3
Bone: tissue strength0.90.93.50.4-0.20.51.91.70.30.8-0.6-0.2
Total heroin consumption1.21.42.6-0.5-0.1-1.3-1.2-1.2-1.4-1.41.6-1.3
Bone: trabecular number0.91.42.71.4-0.81.6-0.1-0.11.70.9-1.41.5
Bone: trabecular spacing0.20.30.5-0.30.50.20.60.60.60.7-0.70.6
Bone: trabecular thickness0.10.10.2-0.30.4-0.30.10.2-0.00.3-0.10.0
Bone: trabecular tissue density1.21.74.52.1-1.92.01.00.81.0-0.4-0.80.3
Water consumed over 24 hours0.50.61.11.0-0.71.0-0.7-0.70.90.2-0.61.1
Number of responses in last shaping day2.52.64.60.6-1.4-0.8-2.1-2.1-1.6-1.82.0-1.4