Hub : Traits

Length without tail

Tags: Physiology

Project: dissection

6 loci · 13 genes with independent associations · 102 total associated genes

Significant Loci

#	Chr	Start pos	End pos	# assoc genes	# joint models	Best TWAS P	Best GWAS P	Cond GWAS P	Joint genes
1	chr7	28844728	30734621	2	1	1.55e-09	6.46e-11	4.18e-04	LOC120093563
2	chr9	75969545	77365260	1	1	9.72e-39	1.30e-01	1.00e+00	Zfand2b
3	chr10	10142296	11540234	1	1	3.40e-08	1.41e-06	2.78e-02	Nmral1
4	chr12	22091	6867512	95	8	1.70e-12	2.43e-12	1.00e+00	Fry LOC102549494 N4bp2l2 Rxfp2 Snapc2 Uspl1 Zfp958
5	chr17	83015365	84414485	2	1	4.61e-08	1.09e-06	2.46e-01	Enkur
6	chr18	2377134	3773732	1	1	4.98e-08	2.09e-02	5.02e-02	Cables1

Pleiotropic Associations

Trait	Chi2 ratio	# genes+	# genes++	% genes++	Corr	Corr P	Genes
BMI with tail	4.4	8	1	7.7	0.99	2.68e-18	Fry Hsph1 Insr LOC102546827 LOC102549494 Rxfp2 Snapc2 Zfand2b
BMI without tail	30.2	2	1	7.7	0	1.00e+00	Nmral1 Zfand2b
Body weight	15.87	35	34	261.5	0.99	3.18e-121	Alox5ap B3glct Brca2 Cers4 Fry Hmgb1 Hsph1 Insr Katnal1 Lnc001 LOC102546827 LOC102548389 LOC102549089 LOC102549494 LOC102552452 LOC102553253 LOC108352411 LOC120093563 LOC120095830 LOC120095871 LOC120095879 Mcoln1 Medag N4bp2l1 N4bp2l2 Pet100 Plxnc1 Rxfp2 Snapc2 Stard13 Stxbp2 Trappc5 Uspl1 Wdr95 Zfp958
Epididymis fat weight	58.46	2	1	7.7	0	1.00e+00	Uspl1 Zfand2b
Heart weight	71.7	1	1	7.7	0	1.00e+00	Zfand2b
Left kidney weight	9.63	31	20	153.8	0.98	1.88e-109	Brca2 Cers4 Fry Hmgb1 Hsph1 Insr Lnc001 LOC102546827 LOC102548389 LOC102549089 LOC102549494 LOC102552452 LOC102553253 LOC108352411 LOC120093563 LOC120095830 LOC120095871 LOC120095879 Mcoln1 Medag N4bp2l1 N4bp2l2 Pet100 Rxfp2 Snapc2 Stard13 Stxbp2 Trappc5 Wdr95 Zfand2b Zfp958
Right kidney weight	9.39	34	20	153.8	0.99	4.13e-144	Alox5ap B3glct Brca2 Cers4 Fry Hmgb1 Hsph1 Insr Katnal1 Lnc001 LOC102546827 LOC102548389 LOC102549089 LOC102549494 LOC102552452 LOC102553253 LOC108352411 LOC120095830 LOC120095871 LOC120095879 Mcoln1 Medag N4bp2l1 N4bp2l2 Pet100 Rxfp2 Snapc2 Stard13 Stxbp2 Trappc5 Uspl1 Wdr95 Zfand2b Zfp958
Tail length	9.17	22	13	100	0.79	7.78e-20	Brca2 Cers4 Fry Insr LOC102548389 LOC102549089 LOC102549494 LOC102552452 LOC120093563 LOC120095871 Mcoln1 N4bp2l1 N4bp2l2 Pet100 Plxnc1 Rxfp2 Snapc2 Stard13 Stxbp2 Trappc5 Zfand2b Zfp958
Length with tail	14.56	33	27	207.7	0.94	7.42e-72	Brca2 Cers4 Enkur Fry Hmgb1 Hsph1 Insr Lnc001 LOC102546827 LOC102548389 LOC102549089 LOC102549494 LOC102552452 LOC102553253 LOC108352411 LOC120093563 LOC120095830 LOC120095871 Mcoln1 Medag N4bp2l1 N4bp2l2 Nmral1 Pet100 Plxnc1 Rxfp2 Snapc2 Stard13 Stxbp2 Trappc5 Wdr95 Zfand2b Zfp958
Liver weight, right	9.82	6	1	7.7	0.69	1.38e-03	Fry LOC102549494 LOC108352411 LOC120095830 Rxfp2 Zfand2b
Parametrial fat weight	9.99	1	0	0	0	1.00e+00	Zfand2b
Retroperitoneal fat weight	4.77	7	0	0	0.37	4.09e-01	Alox5ap Hmgb1 Katnal1 LOC120095879 Nmral1 Uspl1 Zfand2b
Intraocular pressure	51.69	1	1	7.7	0	1.00e+00	Zfand2b
Extensor digitorum longus weight	5.53	19	8	61.5	0.99	1.18e-86	Brca2 Cers4 Fry Insr LOC102548389 LOC102549089 LOC102549494 LOC102552452 LOC120095871 Mcoln1 N4bp2l1 N4bp2l2 Pet100 Rxfp2 Snapc2 Stard13 Stxbp2 Trappc5 Zfp958
Tibialis anterior weight	7.46	20	15	115.4	0.99	9.31e-85	Brca2 Cers4 Fry Insr LOC102548389 LOC102549089 LOC102549494 LOC102552452 LOC120095830 LOC120095871 Mcoln1 N4bp2l1 N4bp2l2 Pet100 Rxfp2 Snapc2 Stard13 Stxbp2 Trappc5 Zfp958
Tibia length	6.42	15	2	15.4	0.99	2.67e-70	Brca2 Insr LOC102549089 LOC102549494 LOC120093563 LOC120095830 Mcoln1 N4bp2l1 N4bp2l2 Pet100 Plxnc1 Rxfp2 Snapc2 Stard13 Stxbp2
Number of licking bursts	32.5	1	1	7.7	0	1.00e+00	Zfand2b
Food consumed during 24 hour testing period	15.78	1	0	0	0	1.00e+00	Zfand2b
Mean num. licks in bursts	18.13	1	0	0	0	1.00e+00	Zfand2b
Std. dev. time between licks in bursts	12.12	1	0	0	0	1.00e+00	Zfand2b
Water consumed over 24 hours	34.33	1	1	7.7	0	1.00e+00	Zfand2b
Patch foraging indifference point 0 sec	11.8	1	0	0	0	1.00e+00	Zfand2b
Patch foraging indifference point AUC	24.2	1	1	7.7	0	1.00e+00	Zfand2b
Indifference point function ln k	54.42	1	1	7.7	0	1.00e+00	Zfand2b
Indifference point function log k	54.42	1	1	7.7	0	1.00e+00	Zfand2b
Patch foraging total patch changes 0 sec	23.48	1	1	7.7	0	1.00e+00	Zfand2b
Patch foraging total patch changes 18 sec	48.28	1	1	7.7	0	1.00e+00	Zfand2b
Patch foraging total patch changes 24 sec	77.61	1	1	7.7	0	1.00e+00	Zfand2b
Patch foraging total patch changes 6 sec	24.67	1	1	7.7	0	1.00e+00	Zfand2b
Patch foraging time to switch 0 sec	33.47	1	1	7.7	0	1.00e+00	Zfand2b
Patch foraging water rate 0 sec	39.47	1	1	7.7	0	1.00e+00	Zfand2b
Patch foraging water rate 12 sec	69.49	1	1	7.7	0	1.00e+00	Zfand2b
Patch foraging water rate 18 sec	9.71	1	0	0	0	1.00e+00	Zfand2b
Patch foraging water rate 24 sec	12.61	1	0	0	0	1.00e+00	Zfand2b
Patch foraging water rate 6 sec	35.43	1	1	7.7	0	1.00e+00	Zfand2b
Locomotor activity	12.38	1	0	0	0	1.00e+00	Zfand2b
Locomotor testing distance	47.2	1	1	7.7	0	1.00e+00	Zfand2b
Locomotor testing rearing	99.51	1	1	7.7	0	1.00e+00	Zfand2b
Light reinforcement 1	19.25	1	1	7.7	0	1.00e+00	Zfand2b
Reaction time number correct	114.79	1	1	7.7	0	1.00e+00	Zfand2b
Reaction time mean minus median	179.03	1	1	7.7	0	1.00e+00	Zfand2b
Reaction time mean minus median AUC	232.47	1	1	7.7	0	1.00e+00	Zfand2b
Reaction time num false alarms AUC	27.43	1	1	7.7	0	1.00e+00	Zfand2b
Reaction time trials correct on left	114.79	1	1	7.7	0	1.00e+00	Zfand2b
Reaction time trials on left	106.69	1	1	7.7	0	1.00e+00	Zfand2b
Reaction time mean	36.11	1	1	7.7	0	1.00e+00	Zfand2b
Reaction time mean AUC	33.75	1	1	7.7	0	1.00e+00	Zfand2b
Median of all reaction times	13.93	2	0	0	0	1.00e+00	Fry Zfand2b
Reaction time omissions	22.83	3	1	7.7	0	1.00e+00	LOC120093563 Plxnc1 Zfand2b
Reaction time premature initiation rate	10.44	3	0	0	-1	1.57e-05	Hmgb1 Katnal1 LOC102553253
Reaction time premature initiations	41.6	1	1	7.7	0	1.00e+00	Zfand2b
Std. dev. reaction times	72.92	1	1	7.7	0	1.00e+00	Zfand2b
Reaction time trials completed	106.69	1	1	7.7	0	1.00e+00	Zfand2b
Reaction time trials AUC	108.76	1	1	7.7	0	1.00e+00	Zfand2b
Cocaine response after cond. corrected	12.71	1	0	0	0	1.00e+00	Zfand2b
Conditioned reinforcement - actives	152.54	1	1	7.7	0	1.00e+00	Zfand2b
Conditioned reinforcement - inactives	135.63	1	1	7.7	0	1.00e+00	Zfand2b
Conditioned locomotion	13.93	1	0	0	0	1.00e+00	Zfand2b
Intermittent access intake day 1-15 change	156.77	1	1	7.7	0	1.00e+00	Zfand2b
Intermittent access intake escalation	117.41	1	1	7.7	0	1.00e+00	Zfand2b
Intermitt. access day 1 inactive lever presses	169.63	1	1	7.7	0	1.00e+00	Zfand2b
Intermitt. access day 15 inactive lever presses	154.3	2	1	7.7	0	1.00e+00	Cables1 Zfand2b
Intermittent access day 1 total infusions	71.42	1	1	7.7	0	1.00e+00	Zfand2b
Intermittent access day 15 total infusions	35.39	1	1	7.7	0	1.00e+00	Zfand2b
Intermittent access terminal intake (last 3 days)	25.82	1	1	7.7	0	1.00e+00	Zfand2b
Intermittent access day 1 locomotion	26.47	1	1	7.7	0	1.00e+00	Zfand2b
Intermittent access day 15 total locomotion	93.08	1	1	7.7	0	1.00e+00	Zfand2b
Intermittent access total locomotion	12.43	1	0	0	0	1.00e+00	Zfand2b
Intermittent access standard deviation	442.51	1	1	7.7	0	1.00e+00	Zfand2b
Cocaine induced anxiety	125.35	1	1	7.7	0	1.00e+00	Zfand2b
Post-drug Anxiety	12.14	1	0	0	0	1.00e+00	Cables1
Baseline Anxiety	393.92	1	1	7.7	0	1.00e+00	Zfand2b
Incentive Sensitization - Responses	309.83	1	1	7.7	0	1.00e+00	Zfand2b
Incentive Sensitization - Breakpoint	300.45	1	1	7.7	0	1.00e+00	Zfand2b
Progressive ratio test 1 active lever presses	26.41	1	1	7.7	0	1.00e+00	Zfand2b
Progressive ratio test 1 breakpoint	19.19	1	0	0	0	1.00e+00	Zfand2b
Progressive ratio test 2 active lever presses	109.22	1	1	7.7	0	1.00e+00	Zfand2b
Progressive ratio test 2 breakpoint	106.65	1	1	7.7	0	1.00e+00	Zfand2b
Progressive ratio test 2 inactive lever presses	63.47	1	1	7.7	0	1.00e+00	Zfand2b
Short access day 1 total inactive lever presses	21.93	1	0	0	0	1.00e+00	Zfand2b
Short access day 10 total inactive lever presses	43.04	1	1	7.7	0	1.00e+00	Zfand2b
Short access day 1 locomotion	129.19	1	1	7.7	0	1.00e+00	Zfand2b
Short access day 10 total locomotion	432.47	1	1	7.7	0	1.00e+00	Zfand2b
Short access total locomotion	209.96	1	1	7.7	0	1.00e+00	Zfand2b
Compulsive drug intake	68.39	1	1	7.7	0	1.00e+00	Zfand2b
One hour access (0.3 mA shock)	17.05	2	0	0	0	1.00e+00	LOC120093563 Zfand2b
One hour access (shock baseline)	14.16	2	0	0	0	1.00e+00	LOC120093563 Plxnc1
Number of responses in last shaping day	67.75	1	1	7.7	0	1.00e+00	Zfand2b
Bone: apparent density	10.85	18	0	0	1	1.29e-74	Cers4 Fry Hmgb1 Hsph1 Lnc001 LOC102546827 LOC102548389 LOC102549494 LOC102552452 LOC108352411 LOC120095830 LOC120095871 Medag Rxfp2 Snapc2 Trappc5 Wdr95 Zfp958
Bone surface	9.9	24	0	0	1	1.70e-88	Brca2 Cers4 Fry Hmgb1 Hsph1 Insr Lnc001 LOC102546827 LOC102548389 LOC102549494 LOC102552452 LOC108352411 LOC120095830 LOC120095871 Mcoln1 N4bp2l1 N4bp2l2 Rxfp2 Snapc2 Stard13 Stxbp2 Trappc5 Wdr95 Zfp958
Bone volume	10.12	16	0	0	1	1.34e-65	Cers4 Fry Hmgb1 Hsph1 Lnc001 LOC102546827 LOC102548389 LOC102549494 LOC102552452 LOC108352411 LOC120095871 Rxfp2 Snapc2 Trappc5 Wdr95 Zfp958
Bone: connectivity density	11.58	20	1	7.7	0.99	1.04e-69	Brca2 Cers4 Fry Hsph1 Insr Lnc001 LOC102546827 LOC102548389 LOC102549494 LOC102552452 LOC108352411 LOC120095830 LOC120095871 Mcoln1 N4bp2l1 Rxfp2 Snapc2 Trappc5 Wdr95 Zfp958
Bone: trabecular number	10.26	13	0	0	1	7.13e-52	Fry Hsph1 Lnc001 LOC102546827 LOC102548389 LOC102549494 LOC108352411 LOC120095830 LOC120095871 Rxfp2 Snapc2 Trappc5 Zfp958
Bone: trabecular thickness	12.04	7	0	0	1	2.75e-24	Cers4 LOC102548389 LOC102552452 LOC120095871 Snapc2 Trappc5 Zfp958
Delta time in open arm before/after self-admin	26.67	1	0	0	0	1.00e+00	Zfand2b
Active lever presses in extinction session 6	26.41	1	0	0	0	1.00e+00	Zfand2b
Time in closed arm before self-admin	44.32	1	1	7.7	0	1.00e+00	Zfand2b
Time in open arm before self-admin	24.67	1	0	0	0	1.00e+00	Zfand2b
Time to tail flick, vehicle, after self-admin	75.62	1	1	7.7	0	1.00e+00	Zfand2b
Delta time to tail flick, vehicle, before/after SA	74.6	1	1	7.7	0	1.00e+00	Zfand2b
Ambulatory time before self-admin	25.36	1	0	0	0	1.00e+00	Zfand2b
Area under the delay curve	31.15	1	1	7.7	0	1.00e+00	Zfand2b
Delay disc. indifference point, 16s delay	69.03	1	1	7.7	0	1.00e+00	Zfand2b
Delay disc. indifference point, 24s delay	27.43	1	0	0	0	1.00e+00	Zfand2b
Delay disc. indifference point, 8s delay	74.24	1	1	7.7	0	1.00e+00	Zfand2b
Delay discount exponential model param	16.14	1	0	0	0	1.00e+00	Zfand2b
Delay discount hyperbolic model param	15.89	1	0	0	0	1.00e+00	Zfand2b
Fecal boli incidents, locomotor time 1	176.47	1	1	7.7	0	1.00e+00	Zfand2b
Time >=10cm from walls, locomotor time 1	79.04	1	1	7.7	0	1.00e+00	Zfand2b
Vertical activity count, locomotor time 1	97.7	1	1	7.7	0	1.00e+00	Zfand2b
Bouts of movement, locomotor time 2	23.9	1	0	0	0	1.00e+00	Zfand2b
Total resting periods, locomotor time 2	36.28	1	1	7.7	0	1.00e+00	Zfand2b
Rest time, locomotor task time 2	44.91	1	1	7.7	0	1.00e+00	Zfand2b
Distance moved, locomotor task time 2	49.51	2	1	7.7	0	1.00e+00	Cables1 Zfand2b
Vertical activity count, locomotor time 2	14.27	2	0	0	0	1.00e+00	Cables1 Zfand2b
Seeking ratio, delayed vs. immediate footshock	13.21	1	0	0	0	1.00e+00	Cables1
Locomotion in novel chamber post-restriction	14.04	1	0	0	0	1.00e+00	Zfand2b
Food seeking constrained by brief footshock	14.98	1	0	0	0	1.00e+00	Zfand2b
Run reversals in cocaine runway, females	36.45	1	1	7.7	0	1.00e+00	Zfand2b
Latency to leave start box in cocaine runway	34.23	1	1	7.7	0	1.00e+00	Zfand2b
Latency to leave start box in cocaine runway, F	31.9	1	1	7.7	0	1.00e+00	Zfand2b
Fe content in liver	12.56	16	0	0	1	2.61e-50	Alox5ap B3glct Fry Hmgb1 Hsph1 Katnal1 Lnc001 LOC102546827 LOC102549494 LOC108352411 LOC120095830 LOC120095879 Medag Rxfp2 Uspl1 Wdr95

Associations by panel

Tissue	RNA modality	# hits	% hits/tests	Avg chisq
Adipose	alternative polyA	2	0.1	2.15
Adipose	alternative TSS	3	0.1	2.13
Adipose	gene expression	8	0.1	2.12
Adipose	isoform ratio	6	0.1	2.1
Adipose	intron excision ratio	1	0	2.06
Adipose	mRNA stability	3	0.1	2.12
BLA	alternative polyA	0	0	2.29
BLA	alternative TSS	2	0.1	2.12
BLA	gene expression	5	0.1	2.21
BLA	isoform ratio	1	0	2.31
BLA	intron excision ratio	1	0	2.27
BLA	mRNA stability	2	0.1	2.23
Brain	alternative polyA	2	0.1	2.27
Brain	alternative TSS	5	0.1	2.21
Brain	gene expression	7	0.1	2.17
Brain	isoform ratio	4	0.1	2.25
Brain	intron excision ratio	6	0.1	2.28
Brain	mRNA stability	1	0	2.11
Eye	alternative polyA	0	0	2.5
Eye	alternative TSS	0	0	2.05
Eye	gene expression	1	0.1	2.17
Eye	isoform ratio	0	0	2.04
Eye	intron excision ratio	0	0	1.92
Eye	mRNA stability	2	0.6	2.28
IL	alternative polyA	1	0.1	2.4
IL	alternative TSS	1	0.2	2.04
IL	gene expression	3	0.1	2.14
IL	isoform ratio	0	0	2.22
IL	intron excision ratio	1	0.1	2.23
IL	mRNA stability	1	0.1	2.16
LHb	alternative polyA	2	0.2	2.25
LHb	alternative TSS	0	0	2.09
LHb	gene expression	2	0.1	2.18
LHb	isoform ratio	0	0	2.24
LHb	intron excision ratio	1	0.1	2.13
LHb	mRNA stability	3	0.2	2.18
Liver	alternative polyA	0	0	2.05
Liver	alternative TSS	3	0.1	2.16
Liver	gene expression	5	0.1	2.13
Liver	isoform ratio	2	0.1	2.17
Liver	intron excision ratio	1	0	2.09
Liver	mRNA stability	5	0.2	2.2
NAcc	alternative polyA	2	0.1	2.29
NAcc	alternative TSS	0	0	2.16
NAcc	gene expression	8	0.1	2.18
NAcc	isoform ratio	7	0.2	2.3
NAcc	intron excision ratio	2	0	2.23
NAcc	mRNA stability	4	0.1	2.2
OFC	alternative polyA	0	0	2.2
OFC	alternative TSS	3	0.4	2.51
OFC	gene expression	5	0.1	2.16
OFC	isoform ratio	3	0.2	2.37
OFC	intron excision ratio	0	0	2.37
OFC	mRNA stability	1	0.1	2.23
PL	alternative polyA	2	0.1	2.28
PL	alternative TSS	2	0.1	2.21
PL	gene expression	4	0	2.17
PL	isoform ratio	4	0.1	2.31
PL	intron excision ratio	3	0.1	2.33
PL	mRNA stability	2	0.1	2.19
pVTA	alternative polyA	0	0	2.17
pVTA	alternative TSS	4	0.3	2.24
pVTA	gene expression	2	0	2.18
pVTA	isoform ratio	3	0.1	2.25
pVTA	intron excision ratio	0	0	2.3
pVTA	mRNA stability	1	0.1	2.26
RMTg	alternative polyA	1	0.2	2.05
RMTg	alternative TSS	0	0	1.82
RMTg	gene expression	0	0	2.19
RMTg	isoform ratio	0	0	2.15
RMTg	intron excision ratio	5	0.6	2.35
RMTg	mRNA stability	0	0	2.17