LOC102555623

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Liver	alternative TSS	XR_005501333.2	0.25	0.09	0.0e+00	0.19	0.21	0.21	0.17	1.3e-20	1.8e-22	3.3e-23	3.1e-18
2	Liver	gene expression	LOC102555623	0.57	0.13	0.0e+00	0.4	0.39	0.41	0.41	8.3e-48	4.9e-46	2.7e-48	2.4e-48
3	pVTA	alternative TSS	XR_352069.4	0.08	0.04	2.1e-04	0.03	0.05	0.03	0.04	4.0e-03	7.5e-05	1.4e-03	4.7e-04
4	Liver	alternative TSS	XR_005501335.2	0.18	0.08	0.0e+00	0.12	0.14	0.14	0.15	8.9e-14	4.2e-15	1.2e-15	6.1e-16
5	PL	gene expression	LOC102555623	0.05	0.02	2.8e-05	0.05	0.05	0.05	0.04	7.7e-06	6.6e-06	9.3e-06	1.1e-05
6	Liver	alternative TSS	XR_005501334.2	0.28	0.1	0.0e+00	0.22	0.21	0.21	0.21	1.5e-23	5.1e-23	3.5e-23	3.5e-23
7	Adipose	gene expression	LOC102555623	0.21	0.09	0.0e+00	0.09	0.15	0.15	0.16	1.8e-10	1.4e-16	2.1e-16	7.9e-18
8	BLA	gene expression	LOC102555623	0.09	0.05	1.8e-04	0.04	0.04	0.04	0.05	2.8e-03	4.2e-03	2.4e-03	1.2e-03
9	NAcc	gene expression	LOC102555623	0.06	0.03	7.1e-10	0.07	0.06	0.06	0.07	2.3e-11	4.4e-10	7.1e-10	3.1e-10

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6	7	8	9
Bone: apparent density	0.8	1.4	3.6	-1.1	-1.1	-1.0	-1.2	-1.9	-1.0	0.1	-1.5	1.1
Area under the delay curve	0.1	0.1	0.2	-0.2	-0.3	-0.5	-0.4	0.4	-0.4	0.0	-0.4	0.3
BMI with tail	1.9	6.5	10.6	3.0	3.1	3.3	2.8	1.0	2.8	2.5	2.2	-1.2
BMI without tail	1.2	6.3	11.2	2.7	2.9	3.3	2.6	0.6	2.9	2.6	2.3	-1.6
Body weight	2.5	10.9	16.4	3.8	3.9	4.0	3.7	1.2	3.7	3.6	2.5	-2.0
Weight adjusted by age	0.1	0.2	1.2	0.1	0.0	0.1	-0.1	1.1	-0.1	-0.0	0.8	0.1
Bone surface	0.3	0.6	2.3	-0.6	-0.7	-0.5	-0.9	-1.5	-0.7	0.1	-0.6	0.6
Bone volume	0.3	0.5	2.4	-0.7	-0.7	-0.5	-0.9	-1.5	-0.5	0.2	-0.4	0.2
Breakpoint value in progressive ratio session	0.3	0.5	1.3	0.5	0.6	0.3	0.8	-0.3	0.4	1.0	-1.1	0.6
Number of licking bursts	0.3	0.9	1.8	1.3	1.2	0.8	1.3	1.1	0.7	0.6	-0.4	0.4
Context. condit. distance diff. score	0.4	0.5	1.9	-0.1	-0.3	-0.5	-0.1	-0.2	-0.6	-0.3	-1.3	1.4
Locomotion velocity, session 1	2.2	2.5	4.6	1.6	1.5	1.4	1.6	2.1	1.6	0.7	1.3	-1.9
Locomotion distance, session 1	2.0	2.6	9.2	1.8	1.6	1.2	1.7	3.0	1.2	0.7	0.9	-1.1
Locomotion velocity, session 2	0.2	0.2	0.8	0.5	0.4	0.3	0.3	0.9	0.3	0.3	-0.4	-0.1
Locomotion distance, session 2	2.2	3.1	14.8	1.6	1.4	0.9	1.5	3.8	1.1	0.2	1.2	-1.7
Locomotion velocity, session 3	1.5	1.8	3.9	1.4	1.3	0.9	1.4	2.0	1.1	0.2	1.3	-1.6
Locomotion distance, session 3	0.1	0.2	0.8	0.5	0.4	0.2	0.4	0.9	0.1	-0.2	0.3	-0.0
Stereotopy head waving bouts, day 3	1.0	1.2	2.9	0.8	1.0	0.9	1.1	1.0	1.2	0.3	1.3	-1.7
Stereotopy head waving duration, day 3	1.4	1.8	2.5	1.4	1.4	1.4	1.5	0.9	1.5	0.9	1.3	-1.6
Locomotion velocity, session 7	1.3	1.5	2.5	1.5	1.4	1.1	1.4	1.6	1.1	1.1	0.6	-0.5
Locomotion distance, session 7	0.7	0.9	2.5	1.4	1.1	0.8	1.0	1.6	0.4	0.6	0.0	0.8
Stereotopy head waving bouts, day 7	0.8	0.9	3.9	-0.7	-0.4	-0.3	-0.3	0.5	0.1	-1.1	1.4	-2.0
Stereotopy head waving duration, day 7	1.0	1.2	4.9	-0.6	-0.3	-0.4	-0.2	0.9	0.2	-1.2	1.8	-2.2
Locomotion velocity, session 8	0.2	0.2	1.3	0.5	0.3	0.1	0.4	1.1	0.2	-0.0	0.2	-0.1
Locomotion distance, session 8	1.6	2.3	9.6	1.9	1.5	0.9	1.8	3.1	0.9	0.6	-0.1	-0.2
Degree of sensitization distance	0.4	0.4	1.4	0.6	0.4	0.4	0.4	-0.0	0.1	0.8	-0.9	1.2
Degree of sensitization stereotypy	0.8	0.8	2.7	-1.0	-0.7	-0.6	-0.6	-0.0	-0.1	-1.1	1.1	-1.6
Conditioned locomotion	0.9	1.1	2.2	-1.5	-1.3	-1.0	-1.4	-1.2	-0.7	-1.0	0.4	-0.5
Cocaine response after cond. corrected	0.1	0.1	0.4	-0.5	-0.3	-0.0	-0.3	-0.6	-0.0	0.3	-0.4	-0.4
Cocaine response after cond. not corrected	0.2	0.3	0.9	-0.7	-0.6	-0.2	-0.7	-1.0	-0.2	0.4	-0.7	0.2
Cocaine response before conditioning	0.0	0.1	0.2	0.2	0.1	0.3	0.0	0.0	0.1	0.4	0.2	0.4
Saline control response	1.0	1.4	4.7	0.6	0.5	0.3	0.4	1.9	0.4	-0.7	2.2	-1.7
Bone: connectivity density	1.7	2.6	4.3	-1.5	-1.6	-1.6	-1.6	-1.7	-1.6	-0.6	-2.1	1.9
Bone: cortical apparent density	0.1	0.2	0.4	0.3	0.4	0.4	0.6	0.4	0.4	0.7	-0.3	0.1
Bone: cortical area	1.0	1.7	3.5	1.3	1.4	1.9	1.0	-0.9	1.2	1.8	1.0	-0.7
Bone: cortical porosity	0.8	0.8	1.7	0.8	0.8	1.0	0.7	1.0	0.8	0.2	1.2	-1.3
Bone: cortical porosity	1.3	1.5	2.6	1.1	1.1	1.3	1.0	1.1	1.2	0.6	1.5	-1.6
Bone: cortical thickness	0.8	1.4	3.6	1.0	1.1	1.6	0.9	-1.2	1.1	1.9	0.2	-0.4
Bone: cortical thickness	0.7	0.9	2.3	0.7	0.8	1.4	0.6	-0.9	1.1	1.5	0.4	-0.6
Bone: cortical tissue density	0.1	0.2	0.4	0.4	0.5	0.4	0.6	0.5	0.4	0.6	-0.2	0.1
Condit. Reinf. active minus inactive responses	2.6	2.9	5.8	1.9	1.8	1.6	2.1	2.4	1.6	1.0	1.2	-1.3
Condit. Reinf. active-inactive response ratio	5.6	6.0	9.6	2.9	2.8	2.5	3.1	2.5	2.6	2.1	1.3	-1.6
Condit. Reinf. active responses	0.9	1.1	4.5	0.8	0.8	0.6	1.1	2.1	0.8	0.1	0.9	-0.9
Condit. Reinf. inactive responses	1.1	1.4	2.7	-1.6	-1.5	-1.3	-1.6	-0.4	-1.2	-1.4	0.0	0.1
Incentive salience index mean	1.3	1.7	2.6	1.5	1.4	1.4	1.6	1.5	1.3	0.8	0.9	-0.9
Condit. Reinf. lever presses	0.0	0.1	0.2	0.0	0.0	0.2	0.1	-0.1	0.0	-0.4	0.4	-0.2
Condit. Reinf. active minus inactive responses	0.2	0.3	2.1	-0.1	-0.0	0.2	-0.1	-1.4	0.1	0.3	-0.0	-0.1
Condit. Reinf. active-inactive response ratio	0.2	0.3	1.8	0.1	0.2	0.2	0.3	-1.3	0.3	0.5	-0.7	0.3
Condit. Reinf. active responses	0.3	0.4	1.2	0.4	0.4	0.7	0.2	-1.1	0.5	0.8	0.3	-0.3
Condit. Reinf. inactive responses	0.6	0.8	1.6	1.0	0.9	1.1	0.7	0.6	0.8	1.0	1.3	-0.8
Condit. Reinf. lever presses	0.3	0.4	1.5	0.3	0.4	0.7	0.1	-1.2	0.3	0.9	0.1	0.2
Condit. Reinf. lever reinforcers received	0.2	0.3	1.4	0.2	0.3	0.6	0.1	-1.2	0.3	0.8	0.2	-0.2
Conditioned reinforcement - actives	0.2	0.8	1.9	-0.4	-0.5	-0.9	-0.2	1.3	-0.5	-1.4	0.6	-1.1
Conditioned reinforcement - inactives	0.2	0.6	1.2	-1.0	-1.0	-1.0	-0.8	0.3	-0.7	-1.1	-0.1	-0.2
Conditioned locomotion	2.1	3.2	5.1	-1.9	-2.0	-2.2	-2.1	-1.1	-2.2	-1.8	-0.8	1.1
Patch foraging indifference point 0 sec	0.4	1.1	2.0	-0.8	-1.0	-1.1	-1.0	0.1	-1.4	-1.0	-1.0	1.3
Patch foraging indifference point AUC	0.2	0.4	0.8	0.7	0.7	0.8	0.6	-0.6	0.5	0.9	0.7	0.6
Delay disc. indifference point, 0s delay	1.6	1.8	3.0	-1.4	-1.5	-1.5	-1.7	-0.8	-1.7	-1.4	-0.9	0.8
Delay disc. indifference point, 16s delay	0.2	0.2	0.7	0.6	0.5	0.2	0.4	0.8	0.2	0.5	0.3	0.0
Delay disc. indifference point, 2s delay	2.2	2.5	4.0	-1.8	-1.8	-1.8	-2.0	-1.0	-1.8	-1.7	-0.9	0.5
Delay disc. indifference point, 24s delay	0.5	0.8	1.2	-1.0	-1.1	-0.9	-1.1	-0.4	-0.9	-0.8	-0.8	0.6
Delay disc. indifference point, 4s delay	0.2	0.2	1.0	-0.3	-0.3	-0.4	-0.3	-0.1	-0.3	0.2	-1.0	0.8
Delay disc. indifference point, 8s delay	0.4	0.7	3.5	0.6	0.6	0.2	0.5	1.9	0.5	0.4	0.8	-1.0
Indifference point function ln k	0.3	0.9	3.6	1.0	0.9	0.6	1.0	1.9	0.6	0.2	0.3	-0.7
Indifference point function log k	0.3	0.9	3.6	1.0	0.9	0.6	1.0	1.9	0.6	0.2	0.3	-0.7
Patch foraging total patch changes 0 sec	0.2	0.7	1.6	-0.5	-0.7	-0.9	-0.7	0.2	-1.2	-0.8	-0.9	1.3
Patch foraging total patch changes 12 sec	0.1	0.2	0.9	0.1	0.0	0.2	-0.0	-0.3	-0.2	0.3	-0.6	0.9
Patch foraging total patch changes 18 sec	0.2	0.4	1.4	-0.2	-0.3	-0.3	-0.3	0.2	-0.8	-0.5	-0.7	1.2
Patch foraging total patch changes 24 sec	0.1	0.2	0.7	0.2	0.2	0.1	0.2	0.8	-0.1	-0.5	0.8	-0.3
Patch foraging total patch changes 6 sec	0.7	1.1	5.0	-0.1	-0.3	-0.1	-0.4	-1.3	-0.8	0.3	-1.6	2.2
Patch foraging time to switch 0 sec	0.4	1.4	2.6	-1.6	-1.4	-1.4	-1.3	-0.5	-1.0	-1.4	-1.0	-0.1
Patch foraging water rate 0 sec	0.2	0.6	1.2	1.1	0.9	0.9	0.8	-0.2	0.6	1.0	0.4	0.4
Patch foraging water rate 12 sec	0.8	3.3	4.7	2.2	2.1	2.0	2.2	1.3	2.0	1.5	1.5	-1.4
Patch foraging water rate 18 sec	0.6	1.4	2.3	1.5	1.4	1.5	1.4	-0.5	1.1	1.5	-0.3	0.4
Patch foraging water rate 24 sec	1.3	1.8	3.8	1.9	1.7	1.5	1.8	1.0	1.2	1.4	0.3	0.2
Patch foraging water rate 6 sec	6.0	8.9	14.2	3.6	3.6	3.2	3.8	2.4	3.3	3.1	1.3	-1.3
Seeking ratio, delayed vs. immediate footshock	2.5	3.6	5.8	-2.2	-2.3	-1.9	-2.4	-1.5	-2.0	-1.6	-1.3	1.6
Distance traveled before self-admin	0.2	0.5	2.4	-0.6	-0.6	-0.4	-0.5	-0.7	-0.3	-1.6	0.7	-0.3
Distance traveled after self-admin	0.1	0.1	0.6	-0.3	-0.3	-0.2	-0.1	0.2	-0.2	-0.8	0.1	0.2
Extensor digitorum longus weight	4.2	16.7	22.8	3.9	4.3	4.8	4.0	1.2	4.8	3.7	4.3	-4.6
Bone: elastic displacement	0.5	0.7	1.4	0.8	0.9	1.2	0.8	-0.1	0.9	0.6	0.9	-0.8
Bone: elastic work	1.6	2.1	3.9	1.6	1.6	2.0	1.5	-0.4	1.7	1.9	0.6	-0.7
Bone: endosteal estimation	0.1	0.3	1.1	0.6	0.5	0.6	0.3	0.1	0.4	0.2	1.0	-0.5
Bone: endosteal perimeter	0.3	0.6	2.6	0.7	0.6	0.7	0.5	0.4	0.6	-0.0	1.6	-0.9
Epididymis fat weight	0.5	2.5	4.1	2.0	1.9	2.0	1.7	1.0	1.6	1.1	1.8	-0.8
Delta time in closed arm before/after self-admin	1.0	1.0	2.8	0.8	0.8	0.4	1.0	1.7	0.7	0.2	1.2	-1.2
Delta time in open arm before/after self-admin	0.6	0.7	2.6	-0.4	-0.3	-0.2	-0.4	0.9	-0.2	-1.1	1.1	-1.6
Diff in mean of infusions in LGA sessions	0.6	1.0	4.7	0.0	-0.0	-0.3	0.3	-0.5	-0.1	0.7	-2.2	1.8
Delay discount exponential model param	0.1	0.1	0.3	0.3	0.3	0.5	0.4	-0.4	0.4	-0.1	0.6	-0.3
Extinction: sum of active levers before priming	0.4	0.5	1.3	0.5	0.5	0.8	0.6	-0.7	0.6	1.2	-1.0	0.5
Active lever presses in extinction session 6	1.1	1.1	2.9	-0.8	-0.9	-1.2	-0.7	-0.2	-1.1	-0.5	-1.7	1.4
Bone: final force	0.3	0.5	0.9	0.9	0.8	1.0	0.8	-0.1	0.7	0.9	0.2	-0.0
Bone: final moment	0.3	0.5	1.0	0.8	0.8	1.0	0.7	-0.3	0.7	1.0	0.1	0.1
Food consumed during 24 hour testing period	1.2	2.4	3.3	1.8	1.8	1.8	1.7	1.3	1.7	1.8	0.7	-1.1
Glucose	1.7	2.6	4.5	2.0	2.0	2.1	1.8	0.7	1.8	2.0	0.8	-0.2
Heart weight	1.0	1.6	2.3	1.5	1.4	1.5	1.1	-0.1	1.3	1.5	1.2	-1.2
Delay discount hyperbolic model param	0.2	0.3	0.5	0.5	0.5	0.7	0.6	-0.2	0.6	0.1	0.7	-0.4
Intermittent access intake day 1-15 change	0.1	0.7	1.4	-0.9	-0.9	-1.0	-0.8	-0.7	-0.8	-1.2	-0.4	0.3
Intermittent access intake escalation	0.3	1.5	1.9	-1.2	-1.3	-1.3	-1.3	-1.2	-1.3	-1.4	-0.9	1.0
Intermittent access intake escalation 2	0.7	1.1	2.5	-1.0	-1.0	-1.0	-0.8	-1.6	-0.8	-0.7	-1.4	1.0
Intermitt. access day 1 inactive lever presses	0.1	0.6	1.1	0.8	0.9	0.8	0.7	1.0	0.7	1.0	0.6	-0.5
Intermitt. access day 15 inactive lever presses	0.2	1.1	2.3	1.0	1.0	1.2	0.8	0.6	1.1	0.8	1.5	-1.2
Intermitt. access escalation Index	0.0	0.1	0.8	-0.0	-0.0	0.1	-0.0	-0.2	0.3	0.0	0.6	-0.9
Intermittent access day 1 total infusions	0.8	2.5	3.4	1.8	1.8	1.8	1.8	1.4	1.8	1.6	1.3	-0.8
Intermittent access day 15 total infusions	0.1	0.2	0.5	0.7	0.6	0.7	0.7	0.0	0.6	0.4	0.1	0.2
Intermittent access terminal intake (last 3 days)	0.4	0.8	1.6	1.2	1.0	1.0	1.3	0.8	1.0	0.6	0.3	-0.2
Intermittent access total infusions	1.5	1.7	2.9	1.6	1.5	1.5	1.7	1.2	1.4	1.1	0.8	-0.5
Intermittent access day 1 locomotion	0.6	1.0	1.5	1.2	1.1	1.2	1.1	0.7	0.9	0.9	1.2	-0.3
Intermittent access day 15 total locomotion	0.2	0.7	1.7	-0.7	-0.7	-0.6	-0.8	-0.9	-0.9	-1.3	0.1	1.0
Intermittent access total locomotion	0.1	0.1	0.3	0.1	0.1	0.3	0.1	-0.5	0.1	-0.0	0.4	0.5
Intermittent access standard deviation	0.0	0.1	0.3	0.4	0.4	0.4	0.5	-0.5	0.4	0.2	-0.2	0.1
Left kidney weight	0.6	4.5	7.5	2.4	2.4	2.7	2.2	0.5	2.4	2.3	1.6	-1.6
Right kidney weight	0.6	4.1	6.3	2.3	2.3	2.5	2.0	0.6	2.2	2.2	1.8	-1.6
Cocaine induced anxiety	0.0	0.1	0.3	0.0	-0.1	-0.2	-0.1	-0.3	-0.4	0.0	-0.6	0.3
Post-drug Anxiety	0.4	0.4	0.7	-0.5	-0.6	-0.7	-0.7	-0.5	-0.8	-0.6	-0.6	0.6
Baseline Anxiety	0.1	0.1	0.2	0.3	0.3	0.4	0.4	0.2	0.5	0.3	0.3	-0.3
Tail length	0.1	0.4	0.8	0.4	0.5	0.8	0.5	-0.4	0.8	0.9	0.5	-0.8
Length with tail	0.6	2.7	4.4	1.8	1.9	1.9	1.8	0.3	1.9	2.1	1.1	-1.1
Length without tail	0.2	0.8	1.5	1.2	1.2	0.9	1.1	0.4	0.8	1.1	0.5	-0.4
Times rat made contact with spout	0.6	0.7	2.9	0.2	0.3	0.3	0.3	-0.5	0.3	1.2	-1.7	1.0
Lifetime Intake	1.4	1.7	2.7	1.6	1.5	1.3	1.7	1.5	1.3	1.0	0.9	-0.7
Liver weight, left	0.1	0.1	0.5	0.3	0.4	0.1	0.4	0.3	0.1	-0.3	0.7	-0.4
Liver weight, right	0.0	0.1	0.2	0.3	0.3	0.2	0.3	-0.3	-0.0	-0.1	-0.2	0.5
Locomotor activity	0.2	0.2	0.9	0.7	0.5	0.4	0.4	0.3	0.3	0.9	-0.1	0.4
Locomotor testing distance	0.4	0.9	2.1	1.2	1.0	1.0	0.9	0.7	0.9	1.4	0.3	-0.1
Locomotor testing rearing	0.8	3.0	7.7	2.0	1.8	1.7	1.9	0.5	1.7	2.8	-1.0	1.1
Locomotion in novel chamber	5.9	8.0	10.1	-2.9	-3.1	-2.7	-3.0	-3.2	-2.8	-1.8	-2.7	3.0
Locomotion in novel chamber post-restriction	0.0	0.1	0.2	-0.4	-0.3	-0.1	-0.2	-0.2	0.1	0.3	-0.4	0.2
Fecal boli incidents, locomotor time 1	0.1	0.2	0.9	0.2	0.1	-0.3	0.2	1.0	0.1	-0.4	0.4	-0.7
Change in fecal boli incidents, locomotor task	0.6	0.7	1.4	0.8	0.9	1.2	0.9	0.2	0.9	0.9	0.7	0.3
Time >=10cm from walls, locomotor time 1	1.0	1.3	4.3	-0.5	-0.6	-0.5	-0.6	-1.6	-0.9	0.0	-1.5	2.1
Bouts of movement, locomotor time 1	0.3	0.4	1.4	0.1	0.0	0.1	-0.1	-0.9	-0.1	0.7	-1.2	1.0
Total resting periods, locomotor time 1	0.2	0.2	0.6	0.4	0.3	0.3	0.2	-0.3	0.2	0.8	-0.7	0.6
Rest time, locomotor task time 1	0.1	0.1	0.8	-0.3	-0.2	-0.3	-0.2	-0.2	0.1	0.1	0.4	-0.9
Distance moved, locomotor task time 1	0.1	0.2	0.5	0.4	0.4	0.7	0.2	0.4	0.1	0.6	0.0	0.4
Vertical activity count, locomotor time 1	0.0	0.2	0.5	-0.2	-0.3	0.0	-0.5	-0.2	-0.6	-0.2	-0.4	0.7
Time >=10cm from walls, locomotor time 2	0.7	1.9	4.1	1.3	1.3	1.4	1.3	1.3	1.3	0.2	2.0	-1.5
Bouts of movement, locomotor time 2	0.3	1.1	1.5	-1.1	-1.2	-1.1	-1.2	-0.9	-1.1	-1.0	-0.9	1.0
Total resting periods, locomotor time 2	0.3	1.2	1.7	-1.2	-1.3	-1.1	-1.3	-0.9	-1.2	-1.0	-0.9	1.0
Rest time, locomotor task time 2	0.5	0.9	1.8	-1.2	-1.1	-0.8	-1.3	-1.3	-0.9	-0.4	-0.3	0.5
Distance moved, locomotor task time 2	0.1	0.1	0.9	0.2	0.2	0.1	0.2	1.0	-0.0	-0.2	0.3	-0.4
Vertical activity count, locomotor time 2	0.0	0.1	0.3	-0.2	-0.2	-0.1	-0.3	0.1	-0.4	-0.6	-0.1	-0.2
Light reinforcement 1	0.7	3.2	5.3	2.3	2.1	2.1	1.9	1.8	1.6	1.6	1.4	-0.8
Light reinforcement 2	0.1	0.2	0.4	0.3	0.4	0.4	0.2	0.1	0.4	0.7	0.5	-0.4
Bone: marrow area	0.1	0.2	0.9	0.6	0.4	0.5	0.2	0.1	0.3	0.1	0.9	-0.4
Bone: maximum diameter	0.2	0.4	0.8	0.8	0.6	0.9	0.2	-0.7	0.3	0.9	0.8	-0.1
Bone: maximum force	0.2	0.5	1.0	1.0	0.8	0.9	0.7	-0.2	0.5	0.9	0.1	0.0
Bone: maximum moment	0.2	0.5	1.1	0.9	0.7	0.9	0.6	-0.5	0.5	1.1	-0.1	0.1
Mean time between licks in bursts	0.0	0.2	0.7	0.3	0.2	0.1	0.2	0.2	-0.2	0.1	-0.9	0.7
Mean num. licks in bursts	0.2	0.6	1.9	-1.0	-0.8	-0.4	-0.9	-1.4	-0.3	0.2	-0.6	0.2
Cd content in liver	0.3	0.3	0.5	0.6	0.6	0.7	0.7	-0.2	0.4	0.7	-0.5	0.7
Co content in liver	4.6	5.4	7.4	2.5	2.5	2.3	2.5	2.7	2.3	1.2	2.4	-2.3
Cu content in liver	1.7	2.0	5.7	-1.0	-1.2	-1.1	-1.0	-0.9	-1.5	-1.0	-2.4	1.9
Fe content in liver	1.8	2.2	3.3	-1.8	-1.8	-1.6	-1.8	-1.4	-1.5	-1.8	0.0	0.0
K content in liver	1.6	1.6	2.6	-1.4	-1.4	-0.9	-1.3	-1.1	-1.3	-1.4	-0.6	1.6
Mg content in liver	0.4	0.4	1.6	-0.4	-0.5	-0.3	-0.4	-0.0	-0.6	-0.7	-0.7	1.3
Mn content in liver	0.2	0.3	1.2	-0.0	-0.0	0.5	-0.1	-1.1	0.1	0.5	-0.6	0.6
Na content in liver	0.3	0.3	0.6	-0.5	-0.5	-0.6	-0.6	-0.7	-0.6	-0.2	-0.4	0.7
Rb content in liver	0.3	0.3	1.6	-0.4	-0.4	-0.5	-0.2	0.5	-0.5	-1.3	0.1	-0.3
Se content in liver	0.3	0.3	0.5	-0.7	-0.7	-0.4	-0.7	-0.5	-0.4	-0.7	0.5	0.0
Sr content in liver	0.2	0.2	0.6	0.2	0.2	0.3	0.2	-0.5	0.6	0.8	0.5	-0.1
Zn content in liver	18.2	21.2	42.2	-3.8	-4.2	-4.0	-4.0	-3.7	-4.8	-3.0	-6.1	6.5
Bone: minimum diameter	2.2	4.2	6.8	2.3	2.3	2.6	2.0	0.8	2.1	2.0	2.0	-1.8
Time in familiar zone, hab. session 1	0.2	0.2	0.6	-0.3	-0.3	-0.4	-0.3	0.3	-0.4	-0.7	0.3	-0.4
Time in novel zone, hab. session 1	0.1	0.1	0.4	-0.3	-0.3	-0.1	-0.3	-0.6	-0.1	-0.0	0.1	0.0
Total zone transitions, hab. session 1	2.3	3.3	10.5	1.6	1.5	1.0	1.6	3.2	1.3	0.4	1.9	-2.3
Total locomotion distance, hab. session 1	0.3	0.4	2.2	0.5	0.4	0.0	0.5	1.5	0.2	-0.1	0.5	-0.5
Locomotion velocity, hab. session 1	0.3	0.4	1.7	0.7	0.7	0.4	0.8	1.3	0.5	0.4	0.3	-0.3
Time in familiar zone, hab. session 2	0.5	0.6	3.6	-0.3	-0.1	0.4	-0.3	-1.9	0.3	0.9	-0.2	0.3
Time in novel zone, hab. session 2	0.4	0.5	2.2	-0.1	-0.3	-0.7	-0.1	1.5	-0.6	-1.1	-0.0	0.1
Total zone transitions, hab. session 2	1.7	2.2	6.6	1.7	1.5	1.0	1.6	2.6	1.1	0.6	1.2	-1.3
Total locomotion distance, hab. session 2	0.7	0.9	1.5	1.2	1.1	0.8	1.1	1.1	0.9	1.1	0.1	-0.0
Locomotion velocity, hab. session 2	0.4	0.6	1.1	1.0	0.8	0.6	1.0	1.0	0.7	0.9	-0.0	0.0
Novel to familiar place preference ratio	0.1	0.1	0.4	0.4	0.3	0.3	0.3	0.7	0.2	0.4	-0.1	0.3
Novelty place preference	0.2	0.2	0.4	0.6	0.4	0.5	0.4	0.7	0.3	0.6	-0.1	0.3
Time in novel zone, NPP test	0.2	0.2	0.4	0.6	0.4	0.5	0.4	0.6	0.3	0.6	-0.1	0.4
Total zone transitions, NPP test	2.1	3.1	5.7	2.0	1.9	1.7	2.0	2.4	1.7	1.2	1.1	-1.4
Total locomotion distance, NPP test	0.4	0.5	0.9	0.9	0.8	0.7	1.0	0.6	0.6	0.8	-0.5	0.4
Locomotion velocity, NPP test	0.5	0.8	1.3	1.1	1.0	0.9	1.1	0.5	0.8	1.2	-0.6	0.4
Intraocular pressure	0.3	0.5	0.8	-0.9	-0.8	-0.7	-0.9	-0.8	-0.6	-0.8	0.0	-0.6
Delta distance traveled before/after self-admin	0.4	0.4	1.7	0.7	0.6	0.3	0.7	1.3	0.3	0.7	-0.1	0.4
Delta ambulatory time before/after self-admin	0.3	0.5	1.1	0.7	0.6	0.3	0.7	0.9	0.3	1.0	-0.5	0.7
Parametrial fat weight	0.1	0.3	0.8	-0.2	-0.3	-0.4	-0.2	-0.6	-0.4	-0.7	-0.4	0.9
Pavlov. Cond. lever latency	1.1	1.4	2.2	1.2	1.3	1.2	1.3	0.7	1.5	1.5	0.7	-0.9
Pavlov. Cond. magazine entry latency	0.2	0.3	0.9	-0.0	0.0	-0.1	0.0	0.7	0.0	-0.7	1.0	-0.6
Pavlov. Cond. change in total contacts	0.3	0.3	1.0	-0.3	-0.4	-0.7	-0.3	1.0	-0.6	-0.9	-0.2	0.2
Pavlov. Cond. index score	0.5	0.6	1.1	-0.8	-0.8	-0.8	-0.8	-0.5	-0.9	-1.0	-0.4	0.6
Pavlov. Cond. latency score	0.8	1.0	1.5	-1.0	-1.1	-1.0	-1.1	-0.6	-1.2	-1.2	-0.6	0.8
Pavlov. Cond. lever contacts	0.6	0.8	1.1	-0.8	-0.9	-0.8	-0.9	-0.8	-1.1	-1.1	-0.6	0.9
Pavlov. Cond. magazine entry number	0.3	0.4	1.2	-0.4	-0.5	-0.2	-0.5	-1.1	-0.4	0.3	-0.8	0.8
Pavlov. Cond. intertrial magazine entries	0.2	0.2	0.3	-0.5	-0.6	-0.5	-0.5	-0.4	-0.6	-0.4	-0.3	0.5
Pavlov. Cond. lever-magazine prob. diff.	0.4	0.5	0.7	-0.7	-0.7	-0.7	-0.7	-0.4	-0.8	-0.8	-0.5	0.8
Pavlov. Cond. response bias	0.1	0.2	0.9	-0.2	-0.2	-0.3	-0.1	0.5	-0.3	-0.9	0.4	-0.3
Pavlov. Cond. lever latency	1.0	1.4	2.1	-1.5	-1.4	-1.4	-1.3	-0.4	-1.1	-1.4	-0.8	0.8
Pavlov. Cond. magazine entry latency	0.1	0.1	0.2	-0.3	-0.4	-0.5	-0.4	-0.2	-0.3	-0.2	0.1	-0.0
Pavlov. Cond. change in total contacts	0.1	0.2	0.4	0.5	0.4	0.4	0.4	-0.3	0.2	0.6	-0.3	0.3
Pavlov. Cond. index score	0.1	0.1	0.7	-0.1	-0.1	-0.1	-0.2	-0.9	-0.2	0.2	0.0	-0.0
Pavlov. Cond. latency score	0.1	0.2	0.7	-0.4	-0.4	-0.5	-0.5	-0.8	-0.5	-0.1	-0.4	0.3
Pavlov. Cond. lever contacts	0.9	1.4	2.0	1.4	1.4	1.4	1.2	0.1	1.2	1.4	1.0	-1.0
Pavlov. Cond. magazine entry number	0.1	0.1	0.4	0.3	0.4	0.5	0.4	0.6	0.4	0.1	0.0	0.0
Pavlov. Cond. intertrial magazine entries	0.1	0.3	1.0	0.3	0.3	0.8	0.1	-1.0	0.4	0.8	-0.1	0.3
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.1	0.9	-0.2	-0.2	-0.2	-0.3	-0.9	-0.3	0.1	-0.1	0.0
Pavlov. Cond. response bias	1.2	1.6	2.0	1.4	1.4	1.4	1.2	0.3	1.3	1.3	1.4	-1.4
Time in closed arm before self-admin	0.1	0.1	0.5	-0.0	-0.1	-0.4	-0.0	0.1	-0.3	-0.0	-0.5	0.7
Time in closed arm after self-admin	0.3	0.4	1.7	0.0	-0.2	-0.5	0.1	0.1	-0.4	0.2	-1.1	1.3
Time in open arm before self-admin	0.8	1.0	3.4	0.8	0.9	1.2	0.8	-0.7	1.1	1.8	-0.3	0.4
Time in open arm after self-admin	0.3	0.3	1.6	-0.1	0.0	0.2	-0.2	0.4	0.2	-0.3	0.7	-1.3
Bone: periosteal estimation	0.6	1.5	2.8	1.4	1.3	1.7	1.0	-0.3	1.2	1.4	1.3	-1.0
Bone: periosteal perimeter	0.7	1.4	3.4	1.2	1.1	1.5	0.8	0.1	1.1	0.9	1.8	-1.4
Bone: post-yield work	0.6	1.0	2.0	-0.7	-0.9	-1.3	-1.0	0.1	-1.4	-1.4	-0.3	0.7
Progressive ratio test 1 active lever presses	2.8	4.9	7.0	2.4	2.4	2.2	2.5	2.6	2.3	1.8	1.9	-1.6
Progressive ratio test 1 breakpoint	2.7	4.6	6.6	2.4	2.3	2.1	2.5	2.6	2.2	1.8	1.7	-1.4
Progressive ratio test 1 inactive lever presses	0.2	0.6	1.0	0.7	0.7	0.8	0.7	0.9	1.0	1.0	0.7	-0.5
Progressive ratio test 2 active lever presses	1.7	2.4	3.3	1.5	1.6	1.6	1.8	1.1	1.8	1.2	1.4	-1.6
Progressive ratio test 2 breakpoint	1.6	2.0	2.9	1.5	1.5	1.6	1.7	1.0	1.7	1.2	1.2	-1.4
Progressive ratio test 2 inactive lever presses	0.1	0.4	1.5	0.1	0.2	0.2	0.4	0.8	0.4	-0.2	0.9	-1.2
Incentive Sensitization - Responses	0.3	0.9	2.4	-1.2	-1.1	-1.0	-0.9	-0.9	-0.8	-1.5	-0.2	-0.2
Incentive Sensitization - Breakpoint	0.4	0.9	2.0	-1.1	-1.0	-0.9	-0.9	-1.1	-0.7	-1.4	-0.2	-0.2
Sum of active levers in priming session hrs 5-6	1.9	1.8	7.0	-0.8	-0.7	-0.5	-0.5	-2.0	-0.4	0.4	-2.7	1.8
Progressive ratio	0.1	0.2	0.5	0.0	0.1	0.5	-0.1	-0.7	0.4	0.3	0.7	-0.5
Food seeking constrained by brief footshock	1.2	1.4	2.3	1.4	1.5	1.5	1.5	-0.2	1.4	1.5	0.1	-0.2
Seeking ratio, punishment vs. effort	0.2	0.5	0.9	0.8	0.7	0.4	1.0	0.8	0.5	0.7	-0.8	0.4
Retroperitoneal fat weight	0.4	1.7	3.1	1.5	1.5	1.8	1.3	-0.4	1.5	1.5	1.0	-0.1
Reaction time number correct	0.1	0.4	1.0	0.7	0.7	0.7	0.7	0.1	0.8	1.0	0.2	-0.3
Reaction time mean minus median	0.2	1.3	2.7	-1.6	-1.4	-1.3	-1.4	-1.0	-1.0	-0.9	-0.1	-0.3
Reaction time mean minus median AUC	0.2	1.2	2.5	-1.6	-1.4	-1.2	-1.3	-1.1	-0.9	-0.7	-0.5	-0.0
Reaction time num false alarms	0.5	0.9	2.8	-0.2	-0.2	-0.4	-0.4	1.7	-0.3	-0.9	1.4	-1.5
Reaction time num false alarms AUC	0.5	1.2	3.9	0.1	0.0	-0.1	-0.1	1.6	0.1	-0.8	1.9	-2.0
Reaction time trials correct on left	0.1	0.4	1.0	0.7	0.7	0.7	0.7	0.1	0.8	1.0	0.2	-0.3
Reaction time trials on left	0.1	0.3	0.8	0.6	0.6	0.6	0.6	-0.0	0.7	0.9	0.1	-0.3
Reaction time mean	0.2	0.4	1.0	-0.9	-0.7	-0.4	-0.7	-1.0	-0.2	0.3	0.2	-0.4
Reaction time mean AUC	0.1	0.3	0.5	-0.7	-0.4	-0.2	-0.5	-0.7	0.1	0.4	0.5	-0.6
Median of all reaction times	0.1	0.2	0.8	-0.2	-0.0	0.2	-0.1	-0.7	0.4	0.9	0.5	-0.5
Reaction time omissions	1.8	3.0	5.1	-2.3	-2.1	-2.0	-2.2	-1.6	-1.7	-1.4	-0.8	0.1
Reaction time false alarm rate	0.5	0.7	1.6	-0.4	-0.5	-0.6	-0.6	1.1	-0.5	-1.1	1.2	-1.3
Reaction time premature initiation rate	1.5	2.3	6.3	1.4	1.5	1.5	1.1	1.4	1.2	0.5	2.5	-1.8
Reaction time premature initiations	1.1	3.2	6.8	1.7	1.8	1.8	1.5	1.4	1.6	1.0	2.6	-2.2
Std. dev. reaction times	0.7	2.3	4.6	-2.2	-1.9	-1.7	-1.9	-1.4	-1.5	-1.3	-0.5	0.1
Reaction time trials completed	0.1	0.3	0.8	0.6	0.6	0.6	0.6	-0.0	0.7	0.9	0.1	-0.3
Reaction time trials AUC	0.1	0.4	1.0	0.7	0.7	0.7	0.7	0.0	0.8	1.0	0.2	-0.3
Run reversals in cocaine runway, females	0.1	0.1	0.4	0.1	0.1	0.2	0.2	0.1	0.2	0.5	-0.7	0.5
Run reversals in cocaine runway, males	1.0	1.1	2.3	1.0	1.0	0.9	1.2	1.0	1.3	1.5	-0.4	-0.1
Latency to leave start box in cocaine runway	0.2	0.3	1.3	-0.2	-0.3	-0.3	-0.4	0.1	-0.6	-0.4	-0.5	1.1
Latency to leave start box in cocaine runway, F	0.1	0.1	0.3	0.1	-0.0	-0.3	-0.1	0.6	-0.4	-0.6	-0.0	0.4
Latency to leave start box in cocaine runway, M	0.8	0.8	2.9	-0.6	-0.7	-0.5	-0.7	-1.0	-0.7	0.0	-1.1	1.7
Std. dev. time between licks in bursts	0.3	0.7	3.3	0.9	0.6	0.2	0.6	1.8	-0.2	-0.3	-0.6	0.8
Total sessions with >9 infusions	1.3	1.6	7.2	1.3	1.1	0.7	1.2	2.7	0.7	0.2	1.1	-0.7
Short access day 1 total inactive lever presses	0.3	0.6	1.9	0.9	0.8	0.7	0.9	1.4	0.5	0.4	0.2	0.2
Short access day 10 total inactive lever presses	0.2	1.5	2.5	-1.4	-1.4	-1.4	-1.6	-0.1	-1.5	-1.4	-0.7	0.6
Short access day 1 total infusions	0.4	0.8	4.5	0.6	0.4	-0.0	0.6	2.1	0.0	-0.8	0.7	-0.6
Short access day 10 total infusions	1.1	1.8	4.9	1.5	1.3	1.1	1.5	2.2	1.3	0.9	0.9	-0.7
Short access total infusions	1.4	2.0	6.4	1.6	1.4	1.0	1.6	2.5	1.2	0.9	1.0	-0.8
Short access day 1 locomotion	0.3	0.6	3.2	0.9	0.7	0.2	0.8	1.8	0.0	-0.2	0.1	0.1
Short access day 10 total locomotion	0.0	0.2	0.7	0.1	0.1	-0.0	0.1	0.2	-0.2	0.4	-0.8	0.8
Short access total locomotion	0.1	0.2	1.0	0.3	0.1	-0.0	0.1	0.7	-0.3	0.1	-0.2	1.0
One hour access (0.3 mA shock)	0.0	0.1	0.2	0.1	0.1	0.3	0.2	-0.5	0.1	0.3	0.1	0.1
Compulsive drug intake	0.2	0.3	1.7	-0.4	-0.3	0.2	-0.5	-1.3	-0.1	0.2	-0.1	0.4
One hour access (shock baseline)	0.2	0.4	0.8	0.7	0.6	0.6	0.9	0.7	0.8	0.4	0.5	-0.5
Social response proportion	0.8	1.0	2.2	-1.2	-1.2	-0.9	-1.3	-0.2	-1.0	-1.5	0.1	0.2
Social responses	0.3	0.4	1.6	-0.1	-0.2	0.2	-0.4	-1.2	-0.3	0.2	-0.7	1.3
Social time	2.1	3.2	4.2	-2.0	-2.0	-1.8	-2.1	-2.0	-1.9	-1.7	-1.1	1.5
Soleus weight	0.9	2.7	4.9	1.4	1.6	1.8	1.5	0.9	1.8	0.9	2.2	-2.0
Bone: stiffness	0.5	0.9	2.3	1.3	1.1	1.2	1.0	0.1	0.9	1.5	0.2	-0.1
Tibialis anterior weight	5.5	19.0	27.2	4.2	4.7	5.2	4.3	0.9	5.2	4.6	4.2	-4.4
Time to tail flick, vehicle, before self-admin	0.6	0.7	1.4	-1.0	-1.0	-0.9	-1.0	0.2	-1.0	-1.2	0.2	-0.3
Time to tail flick, vehicle, after self-admin	0.7	1.4	3.1	-1.3	-1.3	-1.1	-1.5	-1.2	-1.2	-1.8	0.3	-0.3
Time to tail flick, test, before self-admin	1.2	1.3	2.5	-1.4	-1.4	-1.1	-1.6	-1.2	-1.4	-1.0	-0.3	0.4
Time to tail flick, test, after self-admin	0.1	0.1	0.3	-0.3	-0.3	-0.4	-0.4	-0.2	-0.5	-0.4	-0.2	0.2
Delta time to tail flick, vehicle, before/after SA	0.1	0.1	0.2	0.5	0.4	0.3	0.3	-0.0	0.2	-0.3	0.4	-0.1
Delta time to tail flick, test, before/after SA	0.6	0.7	1.6	1.1	1.1	0.8	1.3	0.8	1.0	0.5	0.2	-0.4
Tibia length	0.6	1.5	3.1	0.9	1.1	1.6	0.8	-0.9	1.4	1.8	1.1	-1.2
Ambulatory time before self-admin	0.2	0.6	2.8	-0.7	-0.7	-0.4	-0.6	-0.4	-0.4	-1.7	0.6	-0.3
Ambulatory time after self-admin	0.4	0.7	2.4	-0.8	-0.8	-0.9	-0.7	0.3	-0.9	-1.6	-0.0	0.3
Bone: tissue strength	0.4	0.4	1.0	1.0	0.8	0.7	0.8	-0.0	0.5	0.9	-0.2	0.4
Total heroin consumption	0.3	0.4	1.8	-0.4	-0.4	-0.3	-0.4	-1.3	-0.4	0.3	-0.9	0.6
Bone: trabecular number	0.9	1.7	2.7	-1.6	-1.6	-1.6	-1.6	-1.0	-1.5	-1.2	-0.6	0.4
Bone: trabecular spacing	0.4	0.6	1.3	0.4	0.5	0.7	0.4	-0.9	0.5	1.0	-0.9	1.1
Bone: trabecular thickness	0.1	0.2	0.8	0.1	0.2	0.1	0.1	0.7	0.2	0.1	0.7	-0.9
Bone: trabecular tissue density	0.2	0.4	1.1	0.3	0.4	0.2	0.5	1.1	0.6	0.5	0.7	-0.9
Water consumed over 24 hours	0.2	0.4	0.9	0.7	0.7	0.6	0.7	0.4	0.6	1.0	-0.3	-0.3
Number of responses in last shaping day	1.9	2.5	6.7	1.2	1.2	0.9	1.2	2.6	1.1	-0.4	2.2	-2.1