Hub : Genes

Ice2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose gene expression Ice2 0.05 0.05 1.1e-04 0.03 0.03 0.03 0.03 2.6e-04 5.0e-04 3.3e-04 3.1e-04
2 Adipose mRNA stability Ice2 0.18 0.19 2.1e-08 0.06 0.06 0.06 0.06 6.3e-07 6.7e-07 5.9e-07 8.2e-07

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bone: apparent density0.40.71.1-0.61.0
Area under the delay curve0.10.10.10.4-0.2
BMI with tail3.611.722.74.80.9
BMI without tail1.43.04.92.21.0
Body weight2.19.012.63.52.3
Weight adjusted by age2.73.15.42.30.9
Bone surface0.30.60.80.60.9
Bone volume0.10.10.20.40.3
Breakpoint value in progressive ratio session0.40.40.70.40.8
Number of licking bursts1.72.03.8-1.9-0.5
Context. condit. distance diff. score0.40.40.8-0.2-0.9
Locomotion velocity, session 10.80.90.90.9-0.9
Locomotion distance, session 10.40.50.9-1.00.0
Locomotion velocity, session 21.92.23.01.2-1.7
Locomotion distance, session 20.00.00.0-0.1-0.2
Locomotion velocity, session 30.10.10.20.1-0.4
Locomotion distance, session 31.21.32.5-1.6-0.2
Stereotopy head waving bouts, day 31.41.63.20.31.8
Stereotopy head waving duration, day 30.81.01.30.91.1
Locomotion velocity, session 70.80.81.5-1.2-0.3
Locomotion distance, session 71.01.32.4-1.5-0.4
Stereotopy head waving bouts, day 71.21.32.41.50.5
Stereotopy head waving duration, day 71.01.22.31.50.4
Locomotion velocity, session 80.00.10.1-0.20.3
Locomotion distance, session 80.40.60.8-0.6-0.9
Degree of sensitization distance0.10.10.2-0.2-0.4
Degree of sensitization stereotypy1.41.52.61.6-0.6
Conditioned locomotion0.10.10.2-0.5-0.1
Cocaine response after cond. corrected2.52.85.42.3-0.4
Cocaine response after cond. not corrected1.21.32.61.60.1
Cocaine response before conditioning1.21.42.2-1.50.8
Saline control response0.40.60.8-0.50.9
Bone: connectivity density1.32.12.5-1.31.6
Bone: cortical apparent density0.10.10.2-0.40.1
Bone: cortical area0.10.10.2-0.0-0.4
Bone: cortical porosity0.30.30.7-0.80.1
Bone: cortical porosity0.70.81.6-1.30.0
Bone: cortical thickness0.71.21.5-1.2-1.0
Bone: cortical thickness0.70.81.5-1.20.1
Bone: cortical tissue density0.10.10.1-0.40.1
Condit. Reinf. active minus inactive responses0.50.60.60.8-0.7
Condit. Reinf. active-inactive response ratio0.50.50.80.4-0.9
Condit. Reinf. active responses0.70.91.51.2-0.6
Condit. Reinf. inactive responses0.30.40.70.8-0.2
Incentive salience index mean0.30.40.70.2-0.8
Condit. Reinf. lever presses0.30.40.5-0.6-0.7
Condit. Reinf. active minus inactive responses1.92.44.00.92.0
Condit. Reinf. active-inactive response ratio2.02.14.00.42.0
Condit. Reinf. active responses0.71.01.50.71.2
Condit. Reinf. inactive responses0.10.10.1-0.3-0.3
Condit. Reinf. lever presses0.30.40.7-0.80.1
Condit. Reinf. lever reinforcers received0.50.71.20.51.1
Conditioned reinforcement - actives0.10.10.20.40.3
Conditioned reinforcement - inactives0.40.51.0-0.11.0
Conditioned locomotion1.11.31.6-1.01.3
Patch foraging indifference point 0 sec0.30.50.70.8-0.5
Patch foraging indifference point AUC0.10.10.1-0.40.3
Delay disc. indifference point, 0s delay0.80.91.60.4-1.3
Delay disc. indifference point, 16s delay0.10.10.1-0.2-0.3
Delay disc. indifference point, 2s delay0.00.00.10.00.2
Delay disc. indifference point, 24s delay0.20.20.4-0.2-0.6
Delay disc. indifference point, 4s delay0.10.10.20.20.5
Delay disc. indifference point, 8s delay0.30.30.50.7-0.5
Indifference point function ln k1.31.82.71.6-1.0
Indifference point function log k1.31.82.71.6-1.0
Patch foraging total patch changes 0 sec0.50.71.01.0-0.7
Patch foraging total patch changes 12 sec0.40.60.7-0.70.8
Patch foraging total patch changes 18 sec0.20.30.5-0.20.7
Patch foraging total patch changes 24 sec0.10.10.1-0.20.3
Patch foraging total patch changes 6 sec0.40.60.91.0-0.4
Patch foraging time to switch 0 sec0.71.12.1-1.50.1
Patch foraging water rate 0 sec2.43.86.52.5-1.1
Patch foraging water rate 12 sec1.42.14.32.1-0.1
Patch foraging water rate 18 sec0.30.40.60.8-0.2
Patch foraging water rate 24 sec0.20.30.40.60.5
Patch foraging water rate 6 sec1.21.72.51.6-0.9
Seeking ratio, delayed vs. immediate footshock0.70.81.31.1-0.5
Distance traveled before self-admin0.10.10.10.20.3
Distance traveled after self-admin0.60.70.80.70.9
Extensor digitorum longus weight3.011.922.74.81.1
Bone: elastic displacement0.20.20.30.40.5
Bone: elastic work0.10.10.10.30.2
Bone: endosteal estimation1.02.14.12.00.3
Bone: endosteal perimeter1.42.95.42.30.6
Epididymis fat weight1.33.05.4-0.72.3
Delta time in closed arm before/after self-admin0.20.20.40.1-0.6
Delta time in open arm before/after self-admin0.60.60.9-0.9-0.6
Diff in mean of infusions in LGA sessions1.01.12.21.50.3
Delay discount exponential model param0.10.10.2-0.50.0
Extinction: sum of active levers before priming0.20.20.3-0.10.5
Active lever presses in extinction session 60.50.50.9-0.21.0
Bone: final force0.10.20.30.6-0.0
Bone: final moment0.00.00.00.2-0.2
Food consumed during 24 hour testing period0.70.91.81.30.1
Glucose0.20.40.60.30.8
Heart weight0.40.61.21.1-0.2
Delay discount hyperbolic model param0.10.10.1-0.40.0
Intermittent access intake day 1-15 change0.40.40.8-0.2-0.9
Intermittent access intake escalation1.31.32.50.1-1.6
Intermittent access intake escalation 21.51.51.91.0-1.4
Intermitt. access day 1 inactive lever presses1.11.22.1-1.50.5
Intermitt. access day 15 inactive lever presses2.22.43.8-1.02.0
Intermitt. access escalation Index0.90.81.61.30.1
Intermittent access day 1 total infusions2.42.84.1-1.22.0
Intermittent access day 15 total infusions1.41.51.8-1.21.3
Intermittent access terminal intake (last 3 days)0.10.10.1-0.40.3
Intermittent access total infusions1.21.32.0-0.81.4
Intermittent access day 1 locomotion3.33.54.1-2.01.7
Intermittent access day 15 total locomotion1.71.83.2-1.80.7
Intermittent access total locomotion0.10.20.3-0.00.5
Intermittent access standard deviation1.81.92.3-1.51.2
Left kidney weight1.13.25.11.22.3
Right kidney weight0.92.43.31.81.2
Cocaine induced anxiety0.10.10.10.1-0.3
Post-drug Anxiety0.60.71.0-1.0-0.5
Baseline Anxiety0.30.30.6-0.8-0.3
Tail length0.20.81.4-0.41.2
Length with tail0.72.55.10.12.2
Length without tail0.51.21.31.21.0
Times rat made contact with spout1.82.12.91.1-1.7
Lifetime Intake2.42.74.0-1.22.0
Liver weight, left0.20.30.30.60.5
Liver weight, right0.30.50.80.40.9
Locomotor activity2.03.15.72.40.7
Locomotor testing distance1.11.83.21.80.6
Locomotor testing rearing1.42.24.42.1-0.0
Locomotion in novel chamber1.21.42.7-0.5-1.6
Locomotion in novel chamber post-restriction0.40.50.5-0.70.6
Fecal boli incidents, locomotor time 11.41.52.40.8-1.6
Change in fecal boli incidents, locomotor task0.20.20.40.0-0.7
Time >=10cm from walls, locomotor time 10.50.50.70.50.8
Bouts of movement, locomotor time 10.20.20.40.60.1
Total resting periods, locomotor time 10.30.30.60.80.1
Rest time, locomotor task time 14.14.56.01.7-2.5
Distance moved, locomotor task time 12.32.52.6-1.61.5
Vertical activity count, locomotor time 11.01.11.7-1.30.7
Time >=10cm from walls, locomotor time 20.00.00.00.20.0
Bouts of movement, locomotor time 21.82.03.82.00.4
Total resting periods, locomotor time 22.02.24.32.10.2
Rest time, locomotor task time 20.50.61.20.0-1.1
Distance moved, locomotor task time 21.61.92.9-1.01.7
Vertical activity count, locomotor time 20.80.80.8-0.90.9
Light reinforcement 11.12.02.81.71.1
Light reinforcement 20.40.61.1-0.1-1.1
Bone: marrow area1.02.14.12.00.4
Bone: maximum diameter1.12.14.02.0-0.3
Bone: maximum force0.10.10.20.40.4
Bone: maximum moment0.00.00.00.10.1
Mean time between licks in bursts0.50.81.4-1.20.4
Mean num. licks in bursts2.83.46.32.5-0.6
Cd content in liver0.00.00.0-0.1-0.1
Co content in liver0.20.20.3-0.40.5
Cu content in liver1.21.52.40.8-1.6
Fe content in liver1.21.52.9-0.1-1.7
K content in liver1.41.42.41.5-0.6
Mg content in liver2.72.84.92.2-0.8
Mn content in liver0.10.10.2-0.10.4
Na content in liver1.31.32.61.6-0.2
Rb content in liver2.22.83.21.8-1.6
Se content in liver0.10.10.2-0.3-0.4
Sr content in liver0.20.10.30.00.5
Zn content in liver0.70.81.1-0.7-1.0
Bone: minimum diameter0.10.20.30.4-0.5
Time in familiar zone, hab. session 10.00.00.1-0.0-0.3
Time in novel zone, hab. session 10.70.71.00.6-1.0
Total zone transitions, hab. session 10.81.11.7-0.8-1.3
Total locomotion distance, hab. session 10.40.61.10.2-1.0
Locomotion velocity, hab. session 10.10.20.30.3-0.5
Time in familiar zone, hab. session 20.10.10.1-0.30.4
Time in novel zone, hab. session 20.20.20.40.3-0.6
Total zone transitions, hab. session 20.00.10.1-0.1-0.3
Total locomotion distance, hab. session 20.10.20.30.6-0.1
Locomotion velocity, hab. session 20.00.00.00.20.0
Novel to familiar place preference ratio1.01.01.41.20.8
Novelty place preference1.01.01.61.30.6
Time in novel zone, NPP test1.31.32.51.60.3
Total zone transitions, NPP test0.10.10.20.5-0.2
Total locomotion distance, NPP test0.40.50.91.00.3
Locomotion velocity, NPP test0.20.30.50.40.7
Intraocular pressure1.11.53.00.31.7
Delta distance traveled before/after self-admin0.40.40.50.60.7
Delta ambulatory time before/after self-admin0.10.10.10.10.4
Parametrial fat weight0.91.73.20.5-1.8
Pavlov. Cond. lever latency0.10.20.3-0.0-0.6
Pavlov. Cond. magazine entry latency0.50.71.3-1.10.3
Pavlov. Cond. change in total contacts0.10.10.1-0.30.2
Pavlov. Cond. index score0.60.81.3-1.20.5
Pavlov. Cond. latency score0.30.40.6-0.80.5
Pavlov. Cond. lever contacts0.00.00.0-0.2-0.0
Pavlov. Cond. magazine entry number1.11.32.31.5-0.6
Pavlov. Cond. intertrial magazine entries0.20.30.50.7-0.3
Pavlov. Cond. lever-magazine prob. diff.0.60.71.1-1.10.6
Pavlov. Cond. response bias0.30.40.6-0.80.3
Pavlov. Cond. lever latency0.30.40.50.40.7
Pavlov. Cond. magazine entry latency3.33.87.0-0.8-2.6
Pavlov. Cond. change in total contacts0.30.50.9-0.2-0.9
Pavlov. Cond. index score1.21.52.9-0.5-1.7
Pavlov. Cond. latency score1.72.14.3-0.1-2.1
Pavlov. Cond. lever contacts0.20.30.50.1-0.7
Pavlov. Cond. magazine entry number2.12.64.11.02.0
Pavlov. Cond. intertrial magazine entries2.43.16.1-0.32.5
Pavlov. Cond. lever-magazine prob. diff.1.01.22.1-0.6-1.4
Pavlov. Cond. response bias0.40.50.8-0.5-0.9
Time in closed arm before self-admin0.30.30.4-0.50.7
Time in closed arm after self-admin0.70.71.0-0.61.0
Time in open arm before self-admin1.51.72.81.7-0.7
Time in open arm after self-admin0.40.50.80.5-0.9
Bone: periosteal estimation0.71.53.01.7-0.3
Bone: periosteal perimeter1.21.93.82.00.1
Bone: post-yield work0.10.10.2-0.40.3
Progressive ratio test 1 active lever presses2.02.04.1-0.02.0
Progressive ratio test 1 breakpoint1.11.22.2-0.41.5
Progressive ratio test 1 inactive lever presses1.41.51.7-1.31.1
Progressive ratio test 2 active lever presses2.52.65.00.52.2
Progressive ratio test 2 breakpoint3.03.46.50.52.5
Progressive ratio test 2 inactive lever presses3.84.47.6-1.12.8
Incentive Sensitization - Responses1.41.42.60.51.6
Incentive Sensitization - Breakpoint1.21.32.40.41.5
Sum of active levers in priming session hrs 5-60.00.00.10.10.3
Progressive ratio0.00.00.0-0.20.0
Food seeking constrained by brief footshock0.30.40.70.80.2
Seeking ratio, punishment vs. effort0.60.81.21.10.6
Retroperitoneal fat weight0.00.10.20.4-0.3
Reaction time number correct0.71.11.21.01.1
Reaction time mean minus median0.20.30.5-0.10.7
Reaction time mean minus median AUC0.00.00.1-0.30.0
Reaction time num false alarms0.91.21.3-1.1-1.0
Reaction time num false alarms AUC0.71.01.1-1.1-0.9
Reaction time trials correct on left0.71.11.21.01.1
Reaction time trials on left0.81.11.21.01.1
Reaction time mean0.40.60.6-0.7-0.8
Reaction time mean AUC0.20.20.4-0.4-0.6
Median of all reaction times0.71.01.1-1.1-0.9
Reaction time omissions0.20.20.30.60.4
Reaction time false alarm rate1.52.22.3-1.4-1.5
Reaction time premature initiation rate0.40.50.80.90.3
Reaction time premature initiations0.81.21.51.20.9
Std. dev. reaction times0.10.10.2-0.1-0.4
Reaction time trials completed0.81.11.21.01.1
Reaction time trials AUC0.71.01.11.00.9
Run reversals in cocaine runway, females1.01.01.4-0.81.2
Run reversals in cocaine runway, males0.10.10.10.2-0.3
Latency to leave start box in cocaine runway1.31.42.71.7-0.3
Latency to leave start box in cocaine runway, F0.30.30.60.8-0.0
Latency to leave start box in cocaine runway, M1.31.22.41.5-0.2
Std. dev. time between licks in bursts1.11.32.3-0.51.5
Total sessions with >9 infusions1.41.62.4-0.91.6
Short access day 1 total inactive lever presses2.12.33.8-0.92.0
Short access day 10 total inactive lever presses0.30.30.6-0.80.1
Short access day 1 total infusions2.02.22.9-1.21.7
Short access day 10 total infusions1.41.62.5-0.81.6
Short access total infusions3.64.04.8-1.82.2
Short access day 1 locomotion1.41.52.5-0.71.6
Short access day 10 total locomotion1.01.12.1-0.31.5
Short access total locomotion1.51.62.0-1.41.1
One hour access (0.3 mA shock)0.60.71.40.21.2
Compulsive drug intake0.90.91.70.3-1.3
One hour access (shock baseline)0.20.30.5-0.20.7
Social response proportion0.40.40.5-0.70.5
Social responses0.10.10.2-0.50.2
Social time0.30.40.7-0.10.8
Soleus weight6.920.439.56.31.1
Bone: stiffness0.50.81.40.51.2
Tibialis anterior weight4.816.427.55.22.3
Time to tail flick, vehicle, before self-admin3.03.05.80.5-2.4
Time to tail flick, vehicle, after self-admin0.10.10.20.30.4
Time to tail flick, test, before self-admin0.40.40.5-0.5-0.7
Time to tail flick, test, after self-admin1.41.42.7-0.3-1.6
Delta time to tail flick, vehicle, before/after SA1.01.01.8-0.51.3
Delta time to tail flick, test, before/after SA0.40.30.50.4-0.7
Tibia length0.00.10.2-0.30.5
Ambulatory time before self-admin0.00.00.0-0.2-0.1
Ambulatory time after self-admin0.40.40.70.20.9
Bone: tissue strength1.01.01.2-0.8-1.1
Total heroin consumption1.92.22.61.61.4
Bone: trabecular number1.11.82.0-1.41.2
Bone: trabecular spacing1.21.63.10.3-1.8
Bone: trabecular thickness0.60.81.0-0.71.0
Bone: trabecular tissue density1.21.72.21.51.1
Water consumed over 24 hours0.70.81.20.7-1.1
Number of responses in last shaping day1.01.01.8-0.41.3