Cpsf7

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	PL	gene expression	Cpsf7	0.28	0.13	1.4e-05	0.02	0.04	0.03	0.03	2.3e-03	9.3e-05	2.2e-04	1.3e-04
2	NAcc	gene expression	Cpsf7	0.19	0.13	6.0e-06	0.02	0.02	0.03	0.02	3.6e-04	4.9e-04	1.3e-05	3.0e-04
3	BLA	gene expression	Cpsf7	0.13	0.14	9.8e-03	0	-0	0	0.02	2.8e-01	4.2e-01	2.6e-01	4.2e-02
4	Liver	intron excision ratio	chr1_216599588_216599850	0.04	0.03	3.8e-03	0.01	0.01	0	0.01	4.4e-02	3.0e-02	1.6e-01	3.0e-02
5	Brain	intron excision ratio	chr1_216608728_216614834	0.02	0.02	8.9e-03	0.03	0.02	0.03	0.02	1.3e-03	3.7e-03	1.0e-03	2.7e-03
6	NAcc	mRNA stability	Cpsf7	0.02	0.01	1.9e-03	0.02	0.02	0.02	0.02	2.6e-04	5.0e-04	7.2e-04	5.9e-04
7	Liver	gene expression	Cpsf7	0.13	0.07	4.8e-04	0.01	0.01	0.02	0.01	3.0e-02	1.3e-02	4.7e-03	2.1e-02
8	Adipose	gene expression	Cpsf7	0.14	0.08	1.4e-03	0.01	0.01	0	0.01	5.5e-02	1.1e-02	3.4e-01	2.3e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6	7	8
Bone: apparent density	0.1	0.2	0.4	-0.6	0.3	-0.5	-0.4	-0.1	-0.5	-0.7	0.2
Area under the delay curve	0.2	0.2	0.8	-0.2	-0.4	-0.4	-0.9	0.4	-0.5	-0.5	0.3
BMI with tail	1.8	6.5	14.6	0.5	-2.5	0.9	-0.0	-3.0	-3.2	-3.8	3.2
BMI without tail	0.4	2.2	3.9	1.5	-1.8	1.0	0.0	-1.1	-1.7	-1.9	2.0
Body weight	2.6	11.5	24.4	1.8	-3.7	1.5	0.8	-3.4	-4.4	-4.9	4.1
Weight adjusted by age	1.0	2.8	5.6	1.5	-2.4	1.8	1.4	-2.0	-1.1	-1.1	1.7
Bone surface	0.6	1.2	2.8	-0.4	-1.2	-0.3	-0.3	-0.7	-1.6	-1.7	1.3
Bone volume	0.3	0.5	1.2	-1.0	-0.1	-0.8	-0.6	-0.3	-0.8	-1.1	0.6
Breakpoint value in progressive ratio session	2.0	3.7	4.9	2.0	-2.1	2.1	2.2	-1.9	-1.8	-1.4	1.8
Number of licking bursts	0.0	0.1	0.2	0.0	-0.1	-0.3	-0.2	0.0	-0.0	-0.5	0.4
Context. condit. distance diff. score	0.0	0.0	0.1	0.3	-0.2	-0.1	-0.2	-0.0	0.1	-0.1	0.2
Locomotion velocity, session 1	0.2	0.2	0.9	0.1	-0.3	1.0	0.6	-0.5	-0.2	0.2	-0.1
Locomotion distance, session 1	0.7	1.0	1.8	0.7	-0.4	1.3	1.0	-1.3	-1.0	-1.1	0.6
Locomotion velocity, session 2	1.8	2.2	3.4	1.0	-1.2	1.3	0.9	-1.7	-1.8	-1.8	1.7
Locomotion distance, session 2	0.8	1.1	2.0	1.2	-0.5	1.4	1.2	-1.2	-0.8	-1.1	0.8
Locomotion velocity, session 3	0.5	0.5	1.5	-0.1	-0.2	-0.6	-1.0	-0.5	-0.7	-1.2	0.9
Locomotion distance, session 3	0.2	0.2	0.5	-0.2	0.1	-0.7	-0.7	0.7	-0.1	0.2	-0.3
Stereotopy head waving bouts, day 3	0.2	0.2	0.8	-0.2	0.4	-0.2	-0.9	0.0	-0.2	-0.6	0.1
Stereotopy head waving duration, day 3	0.2	0.3	0.6	0.6	-0.3	0.0	-0.5	-0.2	-0.4	-0.7	0.7
Locomotion velocity, session 7	0.2	0.2	0.6	-0.2	0.0	-0.6	-0.8	0.5	-0.3	-0.2	0.3
Locomotion distance, session 7	0.1	0.2	0.6	0.4	-0.2	-0.3	-0.8	0.5	-0.3	-0.1	0.3
Stereotopy head waving bouts, day 7	0.1	0.2	0.6	-0.2	-0.8	0.1	0.1	-0.4	-0.4	-0.4	0.3
Stereotopy head waving duration, day 7	0.9	1.1	2.1	0.6	-1.4	0.6	0.5	-0.9	-1.4	-1.3	1.2
Locomotion velocity, session 8	0.2	0.3	0.8	0.9	-0.8	0.3	0.3	0.4	-0.3	-0.4	0.2
Locomotion distance, session 8	0.0	0.0	0.1	0.2	-0.0	-0.1	-0.3	-0.1	0.1	-0.2	0.1
Degree of sensitization distance	0.3	0.3	0.7	0.0	-0.3	0.3	-0.3	-0.8	-0.3	-0.8	0.8
Degree of sensitization stereotypy	0.8	0.8	2.4	0.1	-1.5	0.4	0.6	-1.1	-1.0	-0.9	1.0
Conditioned locomotion	0.8	0.9	1.7	1.1	-1.3	1.2	0.4	-0.8	-0.9	-0.6	1.0
Cocaine response after cond. corrected	0.1	0.2	0.5	0.2	-0.5	0.7	0.2	-0.5	0.5	0.3	-0.0
Cocaine response after cond. not corrected	0.2	0.2	0.5	-0.6	0.1	0.4	0.2	-0.5	0.7	0.7	-0.5
Cocaine response before conditioning	0.5	0.6	2.4	-1.5	1.0	-0.6	0.4	-0.2	0.2	0.5	-0.9
Saline control response	2.1	2.9	3.8	1.5	-1.9	1.7	1.6	-1.6	-1.9	-1.8	1.5
Bone: connectivity density	0.6	0.9	2.4	0.2	-1.0	0.3	0.1	-1.0	-1.5	-1.4	1.1
Bone: cortical apparent density	0.2	0.3	0.8	0.8	-0.2	0.6	0.9	-0.5	-0.6	-0.1	0.5
Bone: cortical area	0.1	0.2	0.5	-0.6	0.4	-0.2	0.1	-0.2	-0.7	-0.5	0.1
Bone: cortical porosity	0.7	0.8	2.3	1.5	-1.1	1.0	0.9	-0.4	-0.3	-0.2	0.6
Bone: cortical porosity	0.9	1.0	2.7	1.7	-1.5	1.2	0.9	-0.5	-0.6	-0.3	0.7
Bone: cortical thickness	2.0	3.3	6.0	1.8	-1.1	2.2	2.4	-1.6	-2.2	-1.4	1.2
Bone: cortical thickness	0.2	0.2	0.8	0.9	0.0	0.5	0.6	-0.2	-0.4	0.2	0.1
Bone: cortical tissue density	0.4	0.6	1.1	1.1	-0.4	0.8	1.1	-0.7	-0.7	-0.3	0.7
Condit. Reinf. active minus inactive responses	1.1	1.2	2.8	0.4	-0.6	1.7	1.5	-1.7	-0.8	-0.8	0.6
Condit. Reinf. active-inactive response ratio	1.5	1.6	4.6	0.9	-0.8	2.1	1.9	-1.6	-0.5	-0.4	0.4
Condit. Reinf. active responses	0.6	0.8	2.6	-0.1	0.1	1.1	1.0	-1.6	-0.6	-0.9	0.6
Condit. Reinf. inactive responses	0.4	0.5	1.7	-1.1	1.3	-0.8	-0.7	-0.1	0.3	-0.1	-0.2
Incentive salience index mean	0.4	0.6	1.5	-0.2	0.1	0.9	0.7	-1.2	-0.8	-0.9	0.4
Condit. Reinf. lever presses	0.2	0.3	0.9	-0.9	0.8	-0.5	-0.4	-0.2	-0.6	-0.6	0.0
Condit. Reinf. active minus inactive responses	0.3	0.4	0.8	-0.9	0.5	0.4	0.4	-0.6	0.7	0.7	-0.5
Condit. Reinf. active-inactive response ratio	0.2	0.3	0.8	-0.9	-0.4	-0.4	-0.5	-0.6	0.8	0.1	0.3
Condit. Reinf. active responses	0.2	0.2	0.5	-0.7	0.4	0.6	0.6	-0.7	0.2	0.2	-0.3
Condit. Reinf. inactive responses	0.3	0.4	1.4	-0.6	1.2	0.2	0.5	0.3	-0.1	0.5	-1.0
Condit. Reinf. lever presses	0.4	0.5	1.6	-0.8	-0.1	0.1	0.3	-1.3	-0.5	-1.0	0.8
Condit. Reinf. lever reinforcers received	0.3	0.4	1.1	-0.5	0.0	0.9	0.9	-1.1	0.0	-0.1	0.1
Conditioned reinforcement - actives	0.1	0.4	1.0	-0.7	0.3	0.1	0.3	-0.1	0.9	1.0	-0.7
Conditioned reinforcement - inactives	0.2	0.5	1.9	-1.4	0.8	-0.8	-0.6	-0.2	0.3	-0.1	-0.2
Conditioned locomotion	2.1	3.1	6.0	-2.2	2.4	-1.8	-2.0	1.4	1.4	1.1	-1.5
Patch foraging indifference point 0 sec	0.2	0.5	1.5	0.5	-0.4	0.7	0.5	-0.6	-1.2	-1.0	0.6
Patch foraging indifference point AUC	0.3	0.7	1.5	0.3	0.2	0.8	1.2	-1.0	-1.1	-0.8	0.6
Delay disc. indifference point, 0s delay	0.3	0.3	1.4	-0.8	-0.4	-0.5	-1.2	0.2	0.1	-0.3	0.0
Delay disc. indifference point, 16s delay	0.0	0.1	0.1	-0.3	-0.0	-0.3	-0.4	0.0	-0.2	-0.2	0.1
Delay disc. indifference point, 2s delay	1.1	1.3	3.3	-1.8	0.5	-1.6	-1.7	0.9	0.4	0.2	-0.7
Delay disc. indifference point, 24s delay	0.0	0.1	0.2	0.1	0.3	-0.2	-0.5	0.3	-0.2	-0.2	0.0
Delay disc. indifference point, 4s delay	0.5	0.5	1.1	0.2	-0.5	-0.5	-0.9	0.3	-1.1	-1.0	0.7
Delay disc. indifference point, 8s delay	0.2	0.4	1.1	0.4	-0.5	-0.5	-1.0	1.1	-0.0	0.2	0.0
Indifference point function ln k	0.8	2.4	4.2	-1.4	1.1	-1.4	-2.0	1.5	1.9	1.5	-1.4
Indifference point function log k	0.8	2.4	4.2	-1.4	1.1	-1.4	-2.0	1.5	1.9	1.5	-1.4
Patch foraging total patch changes 0 sec	0.2	0.6	1.4	0.8	-0.3	0.9	0.7	-0.6	-1.2	-0.9	0.5
Patch foraging total patch changes 12 sec	4.9	6.6	9.2	2.6	-2.1	2.5	2.6	-2.6	-3.0	-2.5	2.5
Patch foraging total patch changes 18 sec	0.3	0.7	1.6	0.5	-0.3	1.1	1.3	-0.9	-0.8	-0.7	0.3
Patch foraging total patch changes 24 sec	1.6	5.5	9.9	1.8	-1.7	1.8	1.6	-2.5	-3.1	-3.1	2.6
Patch foraging total patch changes 6 sec	0.5	0.8	2.1	0.6	-0.4	0.3	0.4	-0.6	-1.4	-1.5	0.9
Patch foraging time to switch 0 sec	0.1	0.4	1.5	-0.2	-1.2	-0.4	-0.5	-0.5	-0.4	-0.7	0.8
Patch foraging water rate 0 sec	0.3	1.3	4.3	-0.6	2.1	-0.6	-0.1	0.9	0.9	1.2	-1.4
Patch foraging water rate 12 sec	0.4	1.6	3.3	-0.7	1.8	-1.1	-0.9	1.4	1.4	1.2	-1.4
Patch foraging water rate 18 sec	0.4	0.8	1.9	-0.3	1.4	-1.0	-1.0	1.2	0.5	0.7	-0.9
Patch foraging water rate 24 sec	0.7	1.0	1.7	-0.2	0.9	-1.0	-0.7	1.2	1.3	1.3	-1.1
Patch foraging water rate 6 sec	0.6	0.9	1.9	-0.0	1.3	-0.8	-0.5	1.4	0.9	1.0	-1.1
Seeking ratio, delayed vs. immediate footshock	0.2	0.3	1.0	-0.4	1.0	-0.4	-0.5	-0.3	-0.2	-0.8	0.4
Distance traveled before self-admin	0.4	1.0	2.0	-0.3	-1.0	0.0	0.6	-1.4	-0.9	-1.4	1.1
Distance traveled after self-admin	0.2	0.4	0.9	0.4	-0.5	0.8	0.9	-0.9	-0.3	-0.5	0.6
Extensor digitorum longus weight	4.8	19.0	26.5	3.5	-4.4	3.6	2.7	-4.7	-5.1	-5.2	5.0
Bone: elastic displacement	0.3	0.4	0.8	0.8	0.0	0.8	0.7	0.3	0.3	0.9	-0.6
Bone: elastic work	1.2	1.5	2.6	1.6	-1.0	1.6	1.5	-0.9	-1.2	-0.8	0.8
Bone: endosteal estimation	1.8	4.4	9.8	-2.4	1.8	-3.0	-3.1	1.8	1.7	0.8	-1.0
Bone: endosteal perimeter	2.7	6.7	13.5	-3.3	1.9	-3.7	-3.7	2.1	2.1	1.1	-1.2
Epididymis fat weight	1.1	5.3	11.4	-3.3	2.4	-3.4	-2.8	1.5	1.5	0.3	-1.4
Delta time in closed arm before/after self-admin	3.8	3.6	6.4	2.5	-1.7	1.8	1.4	-1.5	-2.0	-2.1	1.8
Delta time in open arm before/after self-admin	0.9	1.0	2.3	0.7	-0.9	1.0	1.1	-1.5	-1.0	-0.6	1.1
Diff in mean of infusions in LGA sessions	2.1	3.7	4.3	2.0	-2.1	2.0	1.8	-1.9	-2.0	-1.7	1.9
Delay discount exponential model param	0.2	0.2	0.9	0.2	0.3	0.5	1.0	-0.4	0.5	0.4	-0.2
Extinction: sum of active levers before priming	1.8	2.7	4.2	1.7	-1.9	1.1	0.8	-1.4	-2.0	-1.8	2.0
Active lever presses in extinction session 6	1.3	1.3	1.8	0.6	-1.3	0.8	1.2	-1.4	-1.2	-1.1	1.3
Bone: final force	0.3	0.5	1.3	-0.0	-0.3	0.4	0.3	-0.9	-1.1	-1.1	0.8
Bone: final moment	0.3	0.6	1.4	0.0	-0.3	0.4	0.4	-0.9	-1.2	-1.1	0.8
Food consumed during 24 hour testing period	0.2	0.5	1.0	-0.6	0.7	-0.4	-0.0	0.5	0.8	1.0	-1.0
Glucose	2.3	3.7	5.5	-2.3	1.7	-2.2	-2.2	1.8	2.0	0.9	-1.8
Heart weight	0.5	0.8	4.0	-0.4	-0.0	-1.2	-2.0	0.8	0.1	-0.3	0.1
Delay discount hyperbolic model param	0.2	0.3	1.2	0.5	0.2	0.7	1.1	-0.5	0.4	0.3	-0.1
Intermittent access intake day 1-15 change	0.5	3.0	5.7	-2.1	2.4	-1.5	-0.8	1.2	1.8	1.6	-1.9
Intermittent access intake escalation	0.6	3.2	6.1	-2.2	2.5	-1.5	-0.7	1.1	2.0	1.7	-2.0
Intermittent access intake escalation 2	0.8	1.4	3.1	-1.6	1.8	-1.2	-0.4	0.5	1.2	0.9	-1.1
Intermitt. access day 1 inactive lever presses	0.0	0.4	0.9	-0.7	0.5	-0.4	-0.2	0.2	0.9	0.9	-0.7
Intermitt. access day 15 inactive lever presses	0.2	1.2	3.3	-1.8	1.1	-1.2	-0.8	-0.9	-0.6	-1.4	0.4
Intermitt. access escalation Index	0.3	1.0	2.4	-0.5	1.5	-1.0	-1.1	1.2	0.6	0.8	-1.0
Intermittent access day 1 total infusions	0.8	2.3	6.1	-2.5	1.5	-1.8	-2.4	0.3	0.1	-0.7	-0.2
Intermittent access day 15 total infusions	3.0	7.2	14.9	-3.9	3.7	-2.9	-2.7	1.7	2.1	1.4	-2.3
Intermittent access terminal intake (last 3 days)	2.2	3.8	11.1	-3.3	2.6	-2.3	-2.1	0.6	1.1	0.2	-1.2
Intermittent access total infusions	3.0	3.6	9.4	-3.1	2.4	-2.3	-2.4	0.8	0.9	0.1	-1.0
Intermittent access day 1 locomotion	0.4	0.7	2.2	-1.3	0.8	-0.8	-1.5	-0.2	-0.3	-0.6	0.2
Intermittent access day 15 total locomotion	0.4	1.5	5.6	-2.4	1.3	-1.4	-1.4	-0.4	0.2	-0.5	-0.1
Intermittent access total locomotion	3.0	3.6	11.6	-3.4	2.3	-2.2	-2.5	-0.1	0.4	-0.5	-0.5
Intermittent access standard deviation	0.1	0.4	0.7	-0.8	0.7	-0.3	0.0	0.3	0.8	0.7	-0.8
Left kidney weight	0.3	2.5	7.1	-2.0	0.9	-2.3	-2.7	1.3	0.4	-0.2	-0.6
Right kidney weight	0.2	1.3	3.1	-1.6	0.9	-1.6	-1.7	0.8	0.3	-0.2	-0.6
Cocaine induced anxiety	0.1	0.2	0.6	0.2	-0.6	0.4	0.8	-0.5	0.0	0.3	0.1
Post-drug Anxiety	0.2	0.2	0.7	-0.0	-0.9	0.2	0.3	-0.7	-0.3	-0.4	0.4
Baseline Anxiety	0.1	0.2	0.8	0.2	-0.2	0.0	-0.3	-0.1	-0.7	-0.9	0.5
Tail length	0.3	1.8	4.2	2.0	-1.2	1.5	1.4	-0.6	-1.4	-1.1	1.0
Length with tail	1.1	4.9	8.8	2.0	-2.5	1.3	1.4	-1.8	-2.7	-3.0	2.4
Length without tail	1.3	6.9	13.9	1.6	-2.6	1.6	1.8	-2.7	-3.4	-3.7	2.7
Times rat made contact with spout	0.6	0.7	1.6	1.3	-0.6	1.2	1.2	-0.6	-0.5	-0.3	0.5
Lifetime Intake	1.6	2.0	5.0	-2.2	1.7	-1.7	-2.0	0.6	0.6	-0.0	-0.7
Liver weight, left	0.5	0.8	1.4	-0.5	1.1	-0.7	-0.5	1.0	1.2	1.1	-1.0
Liver weight, right	1.4	2.4	4.0	-1.8	1.9	-1.1	-1.3	1.6	1.4	0.9	-2.0
Locomotor activity	0.4	0.6	1.7	-0.1	1.3	-0.4	0.1	1.0	0.4	0.6	-1.3
Locomotor testing distance	0.3	0.8	2.3	-0.6	1.5	-0.4	-0.1	0.9	0.5	0.8	-1.5
Locomotor testing rearing	0.3	1.0	2.7	-0.8	1.5	-0.2	0.2	0.7	0.9	1.0	-1.6
Locomotion in novel chamber	2.3	3.0	5.2	-2.3	1.7	-2.3	-1.7	1.6	1.4	1.2	-1.5
Locomotion in novel chamber post-restriction	0.3	0.9	2.4	-0.5	0.6	-0.4	-0.4	1.0	1.3	1.5	-1.2
Fecal boli incidents, locomotor time 1	0.2	0.6	2.1	-1.5	0.6	-0.0	0.5	-0.8	0.9	0.4	-0.5
Change in fecal boli incidents, locomotor task	1.4	1.5	3.9	-0.4	0.5	-1.4	-1.9	2.0	0.7	0.7	-1.0
Time >=10cm from walls, locomotor time 1	1.6	2.0	4.3	-2.1	1.2	-1.6	-1.4	0.6	1.6	1.2	-1.1
Bouts of movement, locomotor time 1	2.4	3.1	8.7	1.3	-1.1	2.5	2.9	-2.1	-0.8	-0.9	1.0
Total resting periods, locomotor time 1	1.6	1.9	5.8	0.6	-0.7	1.9	2.4	-1.7	-0.7	-0.7	0.7
Rest time, locomotor task time 1	0.5	0.8	1.7	-1.3	0.9	-0.6	-0.4	0.5	1.3	0.9	-1.0
Distance moved, locomotor task time 1	0.1	0.2	0.6	0.5	-0.8	-0.4	-0.5	0.3	-0.4	0.1	0.4
Vertical activity count, locomotor time 1	0.2	1.1	3.0	0.2	0.6	-0.9	-1.2	1.7	0.6	1.5	-0.9
Time >=10cm from walls, locomotor time 2	0.1	0.4	1.5	-0.6	0.2	-0.4	-0.0	0.2	1.0	1.2	-0.6
Bouts of movement, locomotor time 2	1.4	4.5	9.9	1.5	-1.7	2.8	2.5	-3.1	-1.3	-1.6	1.7
Total resting periods, locomotor time 2	0.9	3.7	9.0	1.2	-1.4	2.6	2.4	-3.0	-1.0	-1.3	1.4
Rest time, locomotor task time 2	0.4	0.7	1.6	-0.8	1.1	-0.5	-0.4	0.5	1.3	0.8	-0.9
Distance moved, locomotor task time 2	0.2	0.3	1.1	0.7	-1.0	0.1	0.3	0.2	-0.4	0.5	0.2
Vertical activity count, locomotor time 2	0.3	0.7	1.9	1.3	-0.6	0.0	-0.1	1.4	-0.0	1.1	-0.4
Light reinforcement 1	0.1	0.7	1.6	-1.2	1.2	-0.3	0.1	0.2	0.7	0.7	-1.1
Light reinforcement 2	0.9	2.1	5.2	-2.3	1.6	-1.9	-1.5	0.8	1.0	0.6	-1.0
Bone: marrow area	2.0	4.9	10.6	-2.5	1.9	-3.1	-3.3	2.0	1.8	0.9	-1.1
Bone: maximum diameter	0.3	0.6	1.4	-1.1	0.6	-1.2	-1.1	0.3	-0.0	-0.3	0.1
Bone: maximum force	0.6	1.1	2.9	-0.3	-0.8	-0.1	-0.2	-1.1	-1.5	-1.7	1.4
Bone: maximum moment	0.6	1.1	2.9	-0.2	-0.7	-0.0	-0.1	-1.1	-1.5	-1.7	1.4
Mean time between licks in bursts	0.2	1.2	2.9	1.7	-0.7	1.7	0.9	-1.0	-0.9	-0.4	0.8
Mean num. licks in bursts	0.2	0.4	1.1	0.9	-0.2	1.0	1.0	-0.3	0.0	0.6	-0.3
Cd content in liver	0.8	0.8	1.3	-1.1	0.3	-0.8	-0.8	0.9	1.0	1.1	-1.0
Co content in liver	0.4	0.5	1.5	0.5	0.7	-0.1	0.1	0.8	0.8	1.2	-0.6
Cu content in liver	0.1	0.1	0.7	0.8	0.2	-0.1	-0.1	0.4	-0.0	0.1	0.1
Fe content in liver	0.0	0.0	0.1	0.3	-0.2	-0.1	-0.3	0.0	0.1	-0.1	0.3
K content in liver	0.2	0.1	0.3	-0.4	0.3	-0.4	-0.4	-0.2	-0.4	-0.5	0.3
Mg content in liver	0.3	0.3	0.7	-0.9	0.8	-0.6	-0.4	0.2	-0.1	-0.4	-0.4
Mn content in liver	1.8	2.0	3.0	1.1	-1.6	1.1	0.7	-1.5	-1.7	-1.6	1.7
Na content in liver	0.1	0.1	0.6	-0.8	0.2	0.2	0.4	-0.4	-0.2	0.0	-0.4
Rb content in liver	2.0	2.4	4.0	-1.2	2.0	-1.2	-1.1	1.6	1.7	1.6	-1.7
Se content in liver	0.2	0.2	0.6	0.1	-0.6	0.0	-0.3	-0.5	-0.2	-0.4	0.8
Sr content in liver	5.8	5.0	6.3	2.3	-2.5	2.3	1.9	-2.3	-2.2	-2.1	2.3
Zn content in liver	2.0	2.3	4.0	1.3	-0.7	1.5	1.3	-1.7	-2.0	-1.7	1.5
Bone: minimum diameter	2.0	3.8	7.3	-2.7	2.4	-2.5	-2.4	1.3	1.3	0.7	-1.2
Time in familiar zone, hab. session 1	0.2	0.2	0.9	-0.5	0.9	0.0	0.1	-0.1	0.0	-0.2	-0.3
Time in novel zone, hab. session 1	0.7	0.7	1.6	-0.6	0.4	-0.6	-0.5	0.9	1.2	1.3	-1.1
Total zone transitions, hab. session 1	0.3	0.5	0.8	0.8	-0.5	0.8	0.9	-0.5	-0.8	-0.5	0.4
Total locomotion distance, hab. session 1	0.0	0.1	0.2	-0.3	0.0	-0.2	-0.2	-0.4	0.0	-0.2	0.3
Locomotion velocity, hab. session 1	0.3	0.4	0.8	0.5	-0.5	0.5	0.4	-0.9	-0.6	-0.7	0.8
Time in familiar zone, hab. session 2	0.5	0.6	1.1	-0.6	0.5	-0.4	-0.0	0.9	1.0	1.1	-1.0
Time in novel zone, hab. session 2	0.4	0.4	1.0	0.4	-0.1	0.5	0.2	-0.8	-1.0	-0.9	0.6
Total zone transitions, hab. session 2	0.4	0.6	1.2	0.1	0.1	0.8	1.0	-0.9	-1.1	-0.9	0.2
Total locomotion distance, hab. session 2	0.1	0.2	0.5	-0.3	0.4	0.3	0.4	-0.7	-0.3	-0.5	0.0
Locomotion velocity, hab. session 2	0.1	0.1	0.4	-0.5	0.6	-0.0	0.1	-0.5	-0.1	-0.4	-0.1
Novel to familiar place preference ratio	1.5	1.9	3.2	1.5	-1.7	0.5	0.2	-0.9	-1.8	-1.7	1.7
Novelty place preference	1.1	1.4	2.3	1.4	-1.5	0.4	0.0	-0.6	-1.4	-1.4	1.5
Time in novel zone, NPP test	1.5	1.8	3.2	1.5	-1.8	0.7	0.2	-0.9	-1.5	-1.6	1.7
Total zone transitions, NPP test	1.0	1.4	2.4	1.1	-0.7	1.5	1.5	-1.1	-1.3	-1.0	0.8
Total locomotion distance, NPP test	0.1	0.2	0.3	0.4	0.3	0.4	0.5	-0.3	-0.5	-0.4	0.1
Locomotion velocity, NPP test	0.1	0.1	0.4	0.3	0.6	0.2	0.3	0.1	-0.4	-0.1	-0.2
Intraocular pressure	0.2	0.3	1.0	0.7	-0.4	1.0	0.6	-0.3	0.4	0.4	0.2
Delta distance traveled before/after self-admin	0.4	0.5	1.8	1.3	-0.1	1.0	0.3	0.4	0.3	0.6	-0.2
Delta ambulatory time before/after self-admin	0.3	0.4	1.0	1.0	-0.1	1.0	0.4	0.4	0.5	0.9	-0.4
Parametrial fat weight	3.8	8.8	18.4	-3.5	2.8	-4.3	-4.3	2.8	1.7	0.8	-1.6
Pavlov. Cond. lever latency	0.2	0.2	0.6	0.6	-0.5	-0.1	-0.1	0.4	0.8	0.7	-0.0
Pavlov. Cond. magazine entry latency	0.3	0.4	1.1	-1.0	-0.1	0.1	0.2	-1.0	-0.5	-0.9	0.5
Pavlov. Cond. change in total contacts	0.2	0.2	0.8	-0.9	0.8	0.1	0.3	-0.5	-0.2	-0.2	-0.2
Pavlov. Cond. index score	0.2	0.2	0.5	-0.7	0.3	0.2	0.4	-0.7	-0.4	-0.6	0.2
Pavlov. Cond. latency score	0.2	0.2	0.9	-0.9	0.5	-0.1	0.1	-0.4	-0.4	-0.5	-0.1
Pavlov. Cond. lever contacts	0.2	0.2	0.8	-0.9	0.7	-0.3	-0.2	-0.0	-0.4	-0.3	-0.3
Pavlov. Cond. magazine entry number	0.3	0.4	1.1	0.3	0.4	-0.5	-0.7	1.0	0.5	0.6	-0.6
Pavlov. Cond. intertrial magazine entries	0.3	0.4	1.2	-0.2	1.1	0.4	1.0	-0.0	-0.2	0.2	-0.6
Pavlov. Cond. lever-magazine prob. diff.	0.2	0.2	0.6	-0.6	0.3	0.2	0.5	-0.8	-0.5	-0.6	0.2
Pavlov. Cond. response bias	0.2	0.3	0.9	-0.5	0.0	0.4	0.5	-1.0	-0.6	-0.6	0.4
Pavlov. Cond. lever latency	0.5	0.7	2.7	0.6	-0.2	-0.6	-0.5	1.6	0.4	0.9	-0.7
Pavlov. Cond. magazine entry latency	3.4	4.9	10.6	1.2	-1.8	2.1	2.1	-3.3	-2.0	-2.2	2.4
Pavlov. Cond. change in total contacts	0.5	1.1	4.4	-0.9	-0.1	0.8	1.1	-2.1	-0.5	-1.0	0.8
Pavlov. Cond. index score	1.6	2.6	7.9	-0.0	-1.0	1.2	1.4	-2.8	-1.2	-1.9	1.8
Pavlov. Cond. latency score	1.5	2.3	7.2	-0.1	-0.9	1.1	1.2	-2.7	-1.2	-1.9	1.8
Pavlov. Cond. lever contacts	0.5	0.8	3.4	-0.6	0.1	0.7	0.8	-1.8	-0.2	-0.9	0.7
Pavlov. Cond. magazine entry number	6.3	8.1	16.3	-1.7	2.8	-2.5	-2.5	4.0	2.6	2.9	-3.2
Pavlov. Cond. intertrial magazine entries	0.8	1.8	3.4	-1.2	1.1	-1.2	-0.8	1.9	1.4	1.4	-1.5
Pavlov. Cond. lever-magazine prob. diff.	1.9	2.9	8.7	0.1	-1.2	1.4	1.5	-2.9	-1.3	-1.9	1.9
Pavlov. Cond. response bias	1.4	1.9	6.3	0.0	-0.6	1.3	1.2	-2.5	-1.1	-1.5	1.5
Time in closed arm before self-admin	0.6	1.0	4.0	-2.0	0.8	-1.3	-0.8	0.3	0.7	0.4	-0.7
Time in closed arm after self-admin	0.5	0.6	1.3	-0.9	1.1	-0.8	-0.5	0.7	0.6	0.3	-0.8
Time in open arm before self-admin	0.6	0.7	2.5	1.3	0.6	-0.0	-0.4	1.6	0.3	0.6	-0.7
Time in open arm after self-admin	0.8	0.9	3.5	1.9	-0.8	1.1	0.8	-0.2	-0.8	-0.2	0.7
Bone: periosteal estimation	0.8	1.9	4.3	-1.9	1.3	-2.1	-2.0	0.9	0.5	0.0	-0.4
Bone: periosteal perimeter	0.5	1.0	3.5	-1.9	1.0	-1.3	-1.2	0.5	0.4	0.1	-0.5
Bone: post-yield work	1.8	3.1	7.4	-2.7	1.1	-2.7	-2.6	1.1	0.7	-0.2	-0.5
Progressive ratio test 1 active lever presses	0.2	0.3	0.7	-0.8	0.6	-0.6	-0.8	0.3	0.3	0.1	-0.2
Progressive ratio test 1 breakpoint	0.2	0.3	0.7	-0.9	0.5	-0.5	-0.8	0.3	0.3	0.1	-0.2
Progressive ratio test 1 inactive lever presses	0.4	1.1	2.7	0.0	-0.7	0.1	0.2	-1.5	-1.3	-1.6	1.4
Progressive ratio test 2 active lever presses	1.6	2.2	5.8	-2.4	2.0	-1.7	-1.5	0.6	1.0	0.4	-1.0
Progressive ratio test 2 breakpoint	1.8	2.2	6.1	-2.5	2.0	-1.8	-1.6	0.6	0.9	0.3	-1.0
Progressive ratio test 2 inactive lever presses	0.7	2.2	6.5	-2.5	2.2	-1.7	-1.4	0.3	0.7	0.1	-0.8
Incentive Sensitization - Responses	0.2	0.4	1.2	-1.1	0.2	-0.7	-0.5	-0.8	-0.3	-0.8	0.4
Incentive Sensitization - Breakpoint	0.3	0.6	1.9	-1.4	0.5	-1.0	-0.7	-0.6	-0.2	-0.7	0.3
Sum of active levers in priming session hrs 5-6	0.5	0.5	1.6	0.6	-0.3	1.0	1.3	-0.8	-0.3	-0.1	0.5
Progressive ratio	0.1	0.3	1.1	-1.0	0.0	-0.7	-1.1	-0.0	0.1	-0.3	0.2
Food seeking constrained by brief footshock	0.1	0.1	0.2	0.0	0.2	0.4	-0.1	-0.0	0.3	0.5	-0.4
Seeking ratio, punishment vs. effort	0.1	0.3	1.3	1.1	0.1	0.9	0.6	-0.1	-0.2	0.0	-0.1
Retroperitoneal fat weight	3.5	15.5	25.1	-4.2	4.2	-5.0	-4.8	4.0	3.3	2.0	-3.1
Reaction time number correct	0.2	0.8	2.6	0.5	-1.6	0.8	1.0	-0.5	-0.7	-0.9	0.4
Reaction time mean minus median	0.2	1.1	2.3	0.6	-1.5	1.5	1.2	-1.0	-0.6	-0.3	0.9
Reaction time mean minus median AUC	0.2	1.3	3.2	0.8	-1.5	1.8	1.7	-0.9	-0.2	0.1	0.5
Reaction time num false alarms	0.1	0.2	0.6	0.8	0.6	0.3	0.2	0.7	0.1	0.3	-0.4
Reaction time num false alarms AUC	0.2	0.5	2.2	1.5	0.0	0.8	0.6	0.5	-0.6	-0.1	0.1
Reaction time trials correct on left	0.2	0.8	2.6	0.5	-1.6	0.8	1.0	-0.5	-0.7	-0.9	0.4
Reaction time trials on left	0.3	0.9	2.8	0.5	-1.7	0.8	1.1	-0.5	-0.7	-0.9	0.4
Reaction time mean	0.2	0.3	1.3	-0.0	-0.4	1.2	0.7	-0.5	0.3	0.6	0.1
Reaction time mean AUC	0.1	0.3	0.8	-0.4	-0.0	0.9	0.5	-0.3	0.6	0.8	-0.2
Median of all reaction times	0.1	0.2	0.6	-0.2	-0.1	0.8	0.4	-0.4	0.3	0.5	0.1
Reaction time omissions	0.5	0.8	1.4	0.9	-1.2	1.1	1.1	-0.5	-0.5	-0.5	0.8
Reaction time false alarm rate	0.2	0.3	1.3	0.7	1.2	-0.0	-0.3	0.8	-0.0	0.4	-0.2
Reaction time premature initiation rate	1.6	2.5	5.8	0.8	-1.3	0.0	-0.2	-1.3	-2.4	-2.3	2.3
Reaction time premature initiations	1.3	4.0	7.5	1.5	-2.3	0.8	0.8	-1.6	-2.7	-2.6	2.4
Std. dev. reaction times	0.2	0.5	1.9	0.5	-0.7	1.4	1.1	-0.3	0.2	0.6	0.1
Reaction time trials completed	0.3	0.9	2.8	0.5	-1.7	0.8	1.1	-0.5	-0.7	-0.9	0.4
Reaction time trials AUC	0.2	0.7	2.3	0.4	-1.5	0.8	1.0	-0.4	-0.6	-0.9	0.3
Run reversals in cocaine runway, females	0.4	0.4	1.0	-0.2	-0.1	-0.6	-1.0	0.2	-0.9	-1.0	0.6
Run reversals in cocaine runway, males	1.1	1.2	2.7	-0.5	1.4	-0.9	-0.8	1.7	0.5	1.2	-1.2
Latency to leave start box in cocaine runway	1.5	2.0	4.5	-1.8	1.2	-2.1	-2.1	1.3	0.5	0.2	-0.7
Latency to leave start box in cocaine runway, F	0.3	0.4	1.0	-0.9	0.6	-1.0	-0.8	0.2	-0.3	-0.4	0.1
Latency to leave start box in cocaine runway, M	2.5	2.4	3.9	-1.5	1.0	-1.8	-2.0	1.8	1.5	1.3	-1.3
Std. dev. time between licks in bursts	0.1	0.2	0.8	0.1	0.9	-0.2	-0.4	0.5	0.2	0.5	-0.5
Total sessions with >9 infusions	0.1	0.1	0.5	-0.4	0.0	-0.1	-0.7	0.2	0.4	0.4	-0.1
Short access day 1 total inactive lever presses	0.1	0.1	0.4	-0.4	0.3	-0.4	-0.7	0.2	-0.2	-0.3	-0.0
Short access day 10 total inactive lever presses	0.0	0.3	0.8	0.5	0.1	0.6	0.4	-0.0	0.6	0.9	-0.5
Short access day 1 total infusions	0.4	0.8	1.2	-0.9	1.0	-0.8	-1.1	0.9	0.7	0.6	-0.8
Short access day 10 total infusions	0.6	1.0	3.2	-1.7	0.9	-1.1	-1.8	0.1	0.2	-0.3	-0.2
Short access total infusions	0.5	0.7	2.4	-1.1	0.7	-0.9	-1.5	0.4	0.2	-0.2	-0.2
Short access day 1 locomotion	0.1	0.2	0.9	-0.5	1.0	-0.4	-0.5	0.3	0.1	0.1	-0.3
Short access day 10 total locomotion	0.1	0.4	0.9	-0.9	0.2	-0.3	-1.0	-0.8	-0.0	-0.5	0.4
Short access total locomotion	0.2	0.4	1.0	-1.0	0.7	-0.4	-1.0	-0.4	0.0	-0.3	0.1
One hour access (0.3 mA shock)	2.2	2.7	5.4	-2.3	2.3	-2.0	-1.9	0.8	1.1	0.5	-1.1
Compulsive drug intake	2.0	2.9	6.6	2.6	-2.4	1.9	1.9	-1.1	-0.9	-0.7	1.3
One hour access (shock baseline)	2.9	7.6	14.5	-3.8	3.7	-3.1	-2.8	2.0	2.0	1.5	-2.3
Social response proportion	0.3	0.3	0.9	-0.4	0.5	-0.8	-0.6	1.0	0.1	0.2	-0.5
Social responses	0.1	0.2	0.4	0.6	0.4	-0.1	0.4	0.6	-0.0	0.4	-0.5
Social time	0.5	0.8	2.0	1.4	-0.8	1.3	1.3	-0.1	-0.0	0.4	-0.1
Soleus weight	2.8	8.2	12.6	-2.6	3.6	-2.1	-1.5	2.7	3.1	3.2	-3.5
Bone: stiffness	0.1	0.2	0.5	-0.7	0.2	-0.7	-0.4	-0.2	-0.3	-0.5	0.4
Tibialis anterior weight	7.9	27.1	35.7	4.6	-5.3	5.1	4.3	-5.3	-6.0	-5.5	5.4
Time to tail flick, vehicle, before self-admin	0.2	0.3	0.6	-0.6	-0.5	-0.4	-0.8	-0.2	-0.4	-0.5	0.5
Time to tail flick, vehicle, after self-admin	0.5	1.0	2.2	0.2	-1.5	0.4	-0.0	-1.0	-0.9	-1.4	1.2
Time to tail flick, test, before self-admin	0.4	0.5	1.1	-0.5	0.3	-0.9	-1.0	0.2	-0.7	-1.1	0.4
Time to tail flick, test, after self-admin	0.1	0.1	0.2	-0.4	0.3	-0.2	0.3	-0.0	0.4	0.5	-0.3
Delta time to tail flick, vehicle, before/after SA	0.7	0.7	1.0	0.7	-0.8	1.0	0.9	-1.0	-0.7	-0.9	0.8
Delta time to tail flick, test, before/after SA	0.6	0.8	2.4	0.8	-0.1	1.2	1.6	-0.6	0.5	1.0	-0.3
Tibia length	0.6	1.6	3.3	0.2	-1.4	0.2	0.5	-1.3	-1.7	-1.8	1.5
Ambulatory time before self-admin	0.2	0.5	1.2	-0.6	-0.4	-0.3	0.5	-1.1	-0.6	-0.9	0.7
Ambulatory time after self-admin	0.1	0.1	0.4	-0.7	0.3	-0.1	0.1	-0.4	0.1	-0.2	-0.0
Bone: tissue strength	0.7	0.7	1.2	-0.6	1.0	-0.5	-0.5	0.9	0.9	1.1	-1.1
Total heroin consumption	6.4	7.5	10.7	3.3	-3.2	2.7	2.9	-2.3	-2.6	-2.0	2.7
Bone: trabecular number	0.3	0.6	1.5	0.1	-0.5	-0.1	-0.2	-0.8	-1.1	-1.2	1.0
Bone: trabecular spacing	0.5	0.7	1.4	0.2	0.5	1.0	1.0	0.1	0.8	1.2	-1.0
Bone: trabecular thickness	0.6	0.9	1.6	-1.3	1.3	-1.3	-0.9	0.8	0.6	0.2	-0.6
Bone: trabecular tissue density	2.5	4.4	6.6	-1.4	2.3	-1.5	-1.1	2.3	2.6	2.6	-2.4
Water consumed over 24 hours	0.2	0.4	1.0	1.0	-0.3	0.2	0.6	-0.4	-0.7	-0.7	0.8
Number of responses in last shaping day	1.0	1.3	3.1	1.8	-1.1	1.3	0.9	-0.7	-1.1	-0.8	1.0