Hub : Genes

Gde1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 IC gene expression Gde1 0.07 0.05 3.3e-03 0.05 0.05 0.01 0.04 5.3e-03 3.1e-03 1.1e-01 7.1e-03
2 pVTA gene expression Gde1 0.06 0.04 2.5e-04 0.05 0.05 0.05 0.05 6.8e-05 6.5e-05 4.2e-05 3.8e-05
3 Brain gene expression Gde1 0.19 0.08 1.1e-14 0.11 0.14 0.14 0.14 3.0e-10 9.8e-13 1.4e-12 1.1e-12
4 Liver gene expression Gde1 0.39 0.15 0.0e+00 0.14 0.19 0.18 0.19 1.4e-15 1.6e-20 4.0e-20 6.8e-21
5 BLA gene expression Gde1 0.1 0.06 2.5e-03 0.03 0.02 0.01 0.02 1.1e-02 3.1e-02 6.4e-02 2.9e-02
6 Liver mRNA stability Gde1 0.04 0.02 1.9e-04 0.01 0.02 0.01 0.01 2.4e-02 5.8e-03 8.2e-03 1.7e-02
7 NAcc gene expression Gde1 0.08 0.04 1.6e-09 0.06 0.06 0.06 0.06 1.3e-09 2.7e-09 2.1e-09 1.8e-09
8 PL gene expression Gde1 0.16 0.09 1.7e-08 0.08 0.07 0.08 0.07 1.2e-08 3.8e-08 9.1e-09 3.8e-08
9 Adipose mRNA stability Gde1 0.03 0.02 7.5e-03 0 0.01 0.01 0.01 7.3e-02 1.7e-02 7.0e-02 2.2e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9
Bone: apparent density0.81.42.61.61.31.5-1.21.20.71.21.1-0.7
Area under the delay curve0.30.30.6-0.6-0.1-0.80.4-0.8-0.5-0.6-0.5-0.7
BMI with tail2.910.218.64.33.64.1-3.63.33.12.81.50.4
BMI without tail5.015.426.95.24.25.0-4.04.23.14.13.0-0.5
Body weight2.29.716.64.13.63.9-3.03.42.43.22.6-0.2
Weight adjusted by age0.61.02.40.80.41.0-0.50.80.81.41.21.5
Bone surface0.81.52.91.51.71.2-1.70.71.51.00.50.3
Bone volume1.32.33.92.01.91.7-1.91.21.51.30.8-0.3
Breakpoint value in progressive ratio session0.80.92.8-1.1-1.3-0.61.7-0.3-1.2-0.70.20.5
Number of licking bursts4.06.510.7-3.2-2.6-3.31.7-3.1-1.3-3.0-2.90.2
Context. condit. distance diff. score0.20.20.7-0.4-0.5-0.20.90.1-0.60.20.50.3
Locomotion velocity, session 10.20.20.6-0.20.3-0.4-0.3-0.70.2-0.7-0.8-0.4
Locomotion distance, session 10.91.22.01.30.91.4-0.71.40.51.21.4-0.2
Locomotion velocity, session 20.30.30.6-0.5-0.0-0.70.1-0.8-0.3-0.7-0.7-0.5
Locomotion distance, session 21.11.63.31.71.81.4-1.70.91.40.70.3-0.2
Locomotion velocity, session 30.30.30.90.71.00.6-0.50.50.60.30.40.1
Locomotion distance, session 30.70.81.70.20.8-0.2-0.9-0.61.3-0.9-1.11.1
Stereotopy head waving bouts, day 30.40.51.4-0.7-1.0-0.31.1-0.0-1.20.00.5-0.5
Stereotopy head waving duration, day 30.40.51.4-0.2-0.60.10.80.5-1.00.81.2-0.6
Locomotion velocity, session 71.61.84.91.12.20.6-1.60.22.1-0.1-0.31.6
Locomotion distance, session 70.70.91.9-0.30.5-0.7-0.8-1.01.1-1.1-1.41.2
Stereotopy head waving bouts, day 70.40.41.00.50.40.70.20.8-0.21.01.0-0.3
Stereotopy head waving duration, day 71.92.33.91.81.61.9-0.91.80.92.01.70.1
Locomotion velocity, session 80.00.00.10.10.20.00.0-0.0-0.1-0.2-0.0-0.3
Locomotion distance, session 80.20.20.40.60.70.6-0.40.50.40.30.30.2
Degree of sensitization distance0.60.61.6-0.3-0.90.00.70.3-1.20.60.7-1.2
Degree of sensitization stereotypy1.21.32.71.51.71.3-1.11.11.01.10.80.0
Conditioned locomotion0.80.92.3-0.9-0.2-1.10.4-1.10.4-1.2-1.11.5
Cocaine response after cond. corrected0.30.30.5-0.6-0.5-0.70.3-0.7-0.3-0.7-0.7-0.1
Cocaine response after cond. not corrected0.10.10.20.20.40.0-0.5-0.20.5-0.1-0.40.2
Cocaine response before conditioning1.72.04.91.72.21.2-1.90.72.00.70.10.7
Saline control response0.20.30.7-0.2-0.80.00.60.3-0.80.30.6-0.5
Bone: connectivity density0.61.01.71.31.01.3-1.01.00.91.10.80.3
Bone: cortical apparent density1.01.42.3-1.5-1.4-1.50.9-1.4-0.9-1.2-0.9-0.3
Bone: cortical area2.13.26.22.42.51.9-2.51.31.81.20.7-0.5
Bone: cortical porosity1.21.32.21.31.31.5-0.51.50.71.11.20.5
Bone: cortical porosity0.80.92.00.90.81.20.11.40.30.91.40.6
Bone: cortical thickness0.61.02.41.21.50.8-1.50.30.70.2-0.1-1.5
Bone: cortical thickness0.70.83.60.20.5-0.1-0.7-0.5-0.2-0.9-1.2-1.9
Bone: cortical tissue density1.01.32.2-1.5-1.5-1.50.9-1.3-0.9-1.2-0.8-0.3
Condit. Reinf. active minus inactive responses0.10.20.4-0.1-0.30.20.60.4-0.50.30.60.0
Condit. Reinf. active-inactive response ratio0.30.30.90.20.10.50.40.7-0.00.71.00.6
Condit. Reinf. active responses0.10.10.4-0.2-0.40.10.60.3-0.60.00.2-0.3
Condit. Reinf. inactive responses0.10.10.4-0.1-0.40.00.10.1-0.4-0.3-0.3-0.6
Incentive salience index mean0.10.10.60.20.40.3-0.20.20.50.1-0.00.8
Condit. Reinf. lever presses0.30.41.90.00.3-0.0-0.3-0.10.8-0.3-0.61.4
Condit. Reinf. active minus inactive responses1.82.35.21.40.01.9-0.12.3-0.32.02.3-0.5
Condit. Reinf. active-inactive response ratio1.31.53.70.6-0.81.20.61.7-1.01.51.9-0.7
Condit. Reinf. active responses1.21.63.51.30.31.6-0.31.90.11.71.9-0.1
Condit. Reinf. inactive responses0.81.02.51.11.60.7-1.40.31.60.4-0.00.8
Condit. Reinf. lever presses1.92.65.01.90.92.1-1.02.20.72.11.90.0
Condit. Reinf. lever reinforcers received1.01.43.61.0-0.01.40.01.7-0.21.61.90.0
Conditioned reinforcement - actives0.10.21.30.10.2-0.10.10.1-0.3-0.10.0-1.1
Conditioned reinforcement - inactives0.60.91.7-1.2-1.2-1.30.6-1.0-0.9-0.6-0.7-1.0
Conditioned locomotion0.10.10.2-0.4-0.2-0.50.2-0.3-0.2-0.0-0.1-0.3
Patch foraging indifference point 0 sec0.81.42.91.0-0.11.40.11.6-0.81.51.7-1.3
Patch foraging indifference point AUC0.30.41.30.70.30.6-1.00.40.20.70.1-1.1
Delay disc. indifference point, 0s delay0.91.02.70.41.1-0.2-1.6-0.91.2-0.8-1.5-0.2
Delay disc. indifference point, 16s delay3.13.56.6-2.3-2.5-1.82.6-1.2-2.4-1.3-0.3-0.8
Delay disc. indifference point, 2s delay2.42.76.32.12.51.5-2.50.72.10.6-0.3-0.1
Delay disc. indifference point, 24s delay2.52.85.2-2.3-1.6-2.12.1-1.6-1.7-1.5-0.8-0.1
Delay disc. indifference point, 4s delay0.40.41.8-0.20.6-0.5-0.3-0.7-0.3-0.7-0.8-1.3
Delay disc. indifference point, 8s delay0.20.20.4-0.20.6-0.5-0.3-0.70.2-0.4-0.5-0.3
Indifference point function ln k0.00.10.20.40.40.4-0.20.20.3-0.1-0.0-0.1
Indifference point function log k0.00.10.20.40.40.4-0.20.20.3-0.1-0.0-0.1
Patch foraging total patch changes 0 sec1.01.94.01.1-0.11.60.21.8-0.91.82.0-1.4
Patch foraging total patch changes 12 sec0.30.40.90.60.00.8-0.40.80.01.00.9-0.1
Patch foraging total patch changes 18 sec0.20.31.4-0.0-0.40.10.00.1-0.70.50.2-1.2
Patch foraging total patch changes 24 sec0.71.22.51.00.31.2-0.41.3-0.31.61.5-1.2
Patch foraging total patch changes 6 sec1.52.37.9-0.2-1.40.41.20.9-2.40.81.3-2.8
Patch foraging time to switch 0 sec1.22.45.6-1.9-0.9-1.91.2-1.80.0-1.5-1.22.4
Patch foraging water rate 0 sec0.20.40.90.80.30.9-0.50.90.20.80.6-0.3
Patch foraging water rate 12 sec0.81.73.01.40.81.6-0.41.7-0.31.51.5-1.6
Patch foraging water rate 18 sec0.61.02.20.90.31.20.21.5-0.31.11.4-0.6
Patch foraging water rate 24 sec0.20.31.10.70.50.5-0.60.40.20.30.2-1.0
Patch foraging water rate 6 sec0.40.53.3-0.1-0.6-0.10.3-0.0-0.90.40.2-1.8
Seeking ratio, delayed vs. immediate footshock0.10.10.20.30.10.3-0.20.5-0.00.30.3-0.2
Distance traveled before self-admin0.10.20.80.10.7-0.1-0.50.10.10.1-0.3-0.9
Distance traveled after self-admin1.11.44.31.11.70.5-2.10.11.70.2-0.8-0.2
Extensor digitorum longus weight3.212.630.34.15.52.8-5.41.25.01.3-0.21.2
Bone: elastic displacement0.60.72.0-0.7-0.8-0.51.2-0.2-1.4-0.2-0.0-1.2
Bone: elastic work0.20.30.70.60.80.5-0.60.30.20.30.2-0.7
Bone: endosteal estimation1.63.55.42.22.11.9-2.21.32.31.81.11.3
Bone: endosteal perimeter1.02.05.11.51.71.0-2.00.52.20.6-0.11.5
Epididymis fat weight1.13.66.22.41.62.5-1.32.40.82.32.1-0.6
Delta time in closed arm before/after self-admin1.01.02.80.30.7-0.1-1.1-0.71.5-0.8-1.01.7
Delta time in open arm before/after self-admin1.21.22.31.50.81.5-1.11.30.51.10.5-0.7
Diff in mean of infusions in LGA sessions0.91.02.5-0.2-1.20.31.10.6-1.60.90.9-1.5
Delay discount exponential model param0.30.40.70.70.10.8-0.40.90.50.70.50.6
Extinction: sum of active levers before priming0.40.41.0-0.7-1.0-0.50.7-0.4-0.4-0.5-0.50.6
Active lever presses in extinction session 60.20.20.80.3-0.10.50.30.9-0.30.70.5-0.0
Bone: final force3.35.39.93.03.12.5-3.11.72.41.81.0-0.5
Bone: final moment3.04.98.42.92.82.5-2.81.92.02.01.3-0.6
Food consumed during 24 hour testing period0.81.13.31.41.11.0-1.80.51.30.7-0.0-0.3
Glucose0.10.10.3-0.2-0.0-0.10.3-0.1-0.5-0.10.1-0.6
Heart weight0.00.10.20.30.00.3-0.40.20.10.30.2-0.4
Delay discount hyperbolic model param0.10.10.30.3-0.30.4-0.10.50.20.40.40.5
Intermittent access intake day 1-15 change0.81.63.4-1.4-0.6-1.80.1-1.8-0.1-1.5-1.8-0.2
Intermittent access intake escalation0.81.73.4-1.5-0.7-1.80.3-1.8-0.4-1.6-1.8-0.5
Intermittent access intake escalation 22.12.55.4-1.6-0.7-2.00.2-2.1-0.2-2.3-2.3-0.3
Intermitt. access day 1 inactive lever presses0.20.61.5-1.0-1.1-1.10.2-1.2-0.4-0.4-0.7-0.3
Intermitt. access day 15 inactive lever presses0.10.20.80.40.40.1-0.9-0.10.8-0.1-0.60.2
Intermitt. access escalation Index0.30.41.20.7-0.00.8-0.40.70.11.10.7-0.2
Intermittent access day 1 total infusions0.61.02.21.20.51.3-0.51.50.41.31.1-0.0
Intermittent access day 15 total infusions0.10.10.3-0.2-0.2-0.3-0.0-0.2-0.1-0.2-0.6-0.4
Intermittent access terminal intake (last 3 days)0.00.10.20.30.10.2-0.20.40.10.1-0.1-0.4
Intermittent access total infusions0.70.81.61.20.91.1-0.81.20.50.90.5-0.6
Intermittent access day 1 locomotion0.60.71.90.80.00.9-0.11.3-0.11.41.2-0.5
Intermittent access day 15 total locomotion0.30.51.4-0.2-0.80.00.80.4-1.10.60.4-1.2
Intermittent access total locomotion0.80.92.30.8-0.11.10.11.4-0.41.51.2-0.9
Intermittent access standard deviation0.61.23.30.71.20.0-1.8-0.41.4-0.7-1.7-0.4
Left kidney weight1.56.811.93.53.42.9-3.32.22.62.11.3-0.5
Right kidney weight1.88.415.53.93.63.6-3.33.02.42.41.5-0.9
Cocaine induced anxiety0.10.20.5-0.6-0.5-0.60.0-0.7-0.00.0-0.50.2
Post-drug Anxiety0.60.61.5-0.8-1.0-0.50.9-0.3-1.20.30.3-1.1
Baseline Anxiety0.50.62.30.40.20.40.30.9-0.80.40.9-1.5
Tail length0.51.93.01.71.71.5-1.11.30.61.51.6-1.2
Length with tail0.20.72.40.70.90.70.10.9-0.10.91.5-0.6
Length without tail0.30.92.0-1.2-0.6-1.21.4-0.7-1.0-1.1-0.2-0.0
Times rat made contact with spout1.41.64.40.81.30.1-2.1-0.62.0-0.5-1.60.6
Lifetime Intake1.01.32.41.51.31.4-1.01.50.71.00.7-0.5
Liver weight, left0.50.82.6-0.1-1.00.40.80.9-0.41.01.61.0
Liver weight, right0.20.42.50.0-0.30.20.50.50.3-0.10.41.6
Locomotor activity0.10.20.50.3-0.30.50.10.60.00.60.70.4
Locomotor testing distance0.20.30.60.6-0.00.8-0.20.80.10.70.7-0.0
Locomotor testing rearing0.30.51.90.2-0.50.60.70.9-0.40.91.40.4
Locomotion in novel chamber1.31.73.71.20.41.70.21.9-0.31.81.8-0.4
Locomotion in novel chamber post-restriction0.81.42.6-0.1-1.40.51.41.1-1.61.21.3-1.1
Fecal boli incidents, locomotor time 10.30.52.5-0.3-0.2-0.11.00.50.10.30.61.6
Change in fecal boli incidents, locomotor task1.21.24.50.90.61.1-0.01.3-0.90.81.0-2.1
Time >=10cm from walls, locomotor time 10.30.31.00.51.00.3-0.90.30.80.1-0.3-0.0
Bouts of movement, locomotor time 11.82.04.3-2.0-2.1-1.51.8-0.8-1.6-0.9-0.40.3
Total resting periods, locomotor time 12.12.34.4-2.1-2.0-1.72.0-1.0-1.6-1.2-0.50.5
Rest time, locomotor task time 11.11.42.8-1.5-0.1-1.60.7-1.3-0.1-1.7-1.11.0
Distance moved, locomotor task time 11.11.73.81.50.61.7-0.91.40.11.91.5-1.0
Vertical activity count, locomotor time 10.61.53.61.50.91.2-1.90.60.71.30.3-1.6
Time >=10cm from walls, locomotor time 20.81.23.01.31.70.8-1.70.31.6-0.1-0.50.1
Bouts of movement, locomotor time 20.91.45.40.80.70.8-0.61.01.41.10.92.3
Total resting periods, locomotor time 20.91.54.90.91.01.0-0.81.11.51.10.92.2
Rest time, locomotor task time 20.10.10.50.10.70.10.30.4-0.20.20.5-0.3
Distance moved, locomotor task time 20.60.72.00.10.5-0.4-1.4-1.10.8-0.7-1.2-0.3
Vertical activity count, locomotor time 20.40.62.10.0-0.0-0.4-1.1-0.90.1-0.3-0.8-1.4
Light reinforcement 10.30.71.70.0-0.70.50.91.0-0.91.01.3-0.1
Light reinforcement 20.40.71.80.3-0.60.70.61.2-0.71.11.3-0.3
Bone: marrow area1.43.14.92.12.01.8-2.11.22.21.71.11.2
Bone: maximum diameter1.93.55.82.42.22.1-2.41.62.01.81.20.3
Bone: maximum force2.64.69.22.83.02.3-3.01.52.31.60.9-0.5
Bone: maximum moment2.34.17.02.62.62.2-2.61.61.91.81.2-0.6
Mean time between licks in bursts0.10.10.5-0.5-0.3-0.40.3-0.2-0.1-0.2-0.10.7
Mean num. licks in bursts3.96.110.73.33.02.9-2.82.32.32.31.6-0.1
Cd content in liver3.03.48.1-0.1-1.50.92.21.9-2.32.02.8-1.2
Co content in liver0.70.85.1-0.3-0.3-0.40.2-0.4-1.1-0.4-0.6-2.2
Cu content in liver0.70.91.51.10.91.2-0.61.2-0.00.90.6-1.2
Fe content in liver0.50.62.4-0.6-0.4-0.50.7-0.3-1.2-0.6-0.4-1.5
K content in liver0.20.20.50.60.30.7-0.30.70.10.60.3-0.2
Mg content in liver0.40.40.70.50.50.6-0.20.70.50.80.60.8
Mn content in liver0.40.40.90.70.90.5-0.90.30.90.2-0.10.5
Na content in liver3.43.68.72.12.41.5-2.80.63.00.7-0.41.6
Rb content in liver3.44.011.3-0.8-1.50.12.61.2-3.41.02.1-2.8
Se content in liver0.20.20.50.20.6-0.1-0.7-0.40.7-0.3-0.70.2
Sr content in liver0.60.51.00.90.50.8-1.00.51.00.50.10.6
Zn content in liver2.52.85.21.91.32.0-1.41.91.32.31.70.9
Bone: minimum diameter1.73.15.72.12.41.7-2.31.22.31.20.70.9
Time in familiar zone, hab. session 11.00.92.8-0.8-1.1-0.70.9-0.5-1.4-0.3-0.3-1.7
Time in novel zone, hab. session 11.31.33.61.01.60.8-0.70.71.60.10.41.9
Total zone transitions, hab. session 11.62.24.12.02.01.8-1.71.40.91.10.6-1.3
Total locomotion distance, hab. session 14.05.710.43.22.53.1-2.42.61.32.31.8-1.5
Locomotion velocity, hab. session 13.75.29.03.01.93.0-2.02.71.02.62.1-1.4
Time in familiar zone, hab. session 20.30.30.70.60.50.5-0.60.30.30.80.5-0.5
Time in novel zone, hab. session 20.10.10.2-0.0-0.10.10.40.3-0.2-0.00.30.2
Total zone transitions, hab. session 21.62.13.92.01.71.9-1.31.60.71.21.0-1.0
Total locomotion distance, hab. session 22.02.65.02.21.82.0-1.81.60.91.41.0-1.3
Locomotion velocity, hab. session 22.43.26.12.52.02.2-2.01.81.21.51.0-1.1
Novel to familiar place preference ratio1.21.32.3-1.2-1.5-1.10.7-1.0-1.0-1.5-1.4-0.7
Novelty place preference1.51.73.1-1.3-1.4-1.30.6-1.3-0.9-1.8-1.7-0.8
Time in novel zone, NPP test1.11.21.9-1.1-1.4-1.00.7-0.9-1.1-1.4-1.3-0.9
Total zone transitions, NPP test1.01.52.81.71.61.5-1.41.20.90.90.6-0.6
Total locomotion distance, NPP test0.91.32.61.51.21.3-1.61.00.80.70.4-1.1
Locomotion velocity, NPP test0.71.02.31.41.11.1-1.50.80.70.50.2-1.1
Intraocular pressure0.20.30.50.60.70.5-0.50.40.7-0.00.20.7
Delta distance traveled before/after self-admin0.60.61.30.91.00.7-0.90.41.20.50.10.8
Delta ambulatory time before/after self-admin0.70.92.21.01.20.7-1.40.11.5-0.0-0.50.7
Parametrial fat weight3.37.813.63.22.13.6-1.03.70.13.63.5-1.9
Pavlov. Cond. lever latency1.41.88.8-0.8-0.9-0.80.9-0.7-1.9-0.8-0.4-3.0
Pavlov. Cond. magazine entry latency3.84.98.42.42.02.3-2.12.02.81.81.02.9
Pavlov. Cond. change in total contacts2.42.510.40.81.30.4-1.70.12.60.0-0.53.2
Pavlov. Cond. index score2.43.010.41.41.31.4-1.41.32.41.20.73.2
Pavlov. Cond. latency score2.12.78.41.41.31.4-1.31.32.21.20.72.9
Pavlov. Cond. lever contacts2.63.19.51.51.61.4-1.51.22.51.20.73.1
Pavlov. Cond. magazine entry number2.32.99.1-1.4-1.5-1.21.7-1.0-2.5-0.8-0.2-3.0
Pavlov. Cond. intertrial magazine entries1.61.95.1-1.0-1.7-0.61.7-0.1-2.3-0.40.4-2.1
Pavlov. Cond. lever-magazine prob. diff.2.93.610.81.71.51.6-1.61.42.61.40.83.3
Pavlov. Cond. response bias2.83.512.41.41.71.2-1.80.82.90.70.03.5
Pavlov. Cond. lever latency1.41.93.3-1.6-0.9-1.70.8-1.8-0.7-1.8-1.70.0
Pavlov. Cond. magazine entry latency0.70.81.7-1.0-0.9-1.00.7-0.80.0-0.9-0.71.3
Pavlov. Cond. change in total contacts1.11.74.70.5-0.71.10.81.7-1.21.62.2-1.1
Pavlov. Cond. index score0.20.30.70.3-0.30.50.20.8-0.00.80.90.3
Pavlov. Cond. latency score0.10.20.40.3-0.20.40.00.60.20.60.60.5
Pavlov. Cond. lever contacts1.41.93.51.60.91.7-0.81.80.71.91.70.2
Pavlov. Cond. magazine entry number1.11.33.11.51.81.2-1.50.71.10.90.3-0.5
Pavlov. Cond. intertrial magazine entries2.23.35.42.32.02.2-1.81.91.61.91.50.3
Pavlov. Cond. lever-magazine prob. diff.0.10.20.40.1-0.50.30.30.6-0.00.50.70.5
Pavlov. Cond. response bias0.50.71.60.7-0.10.90.01.20.01.21.30.2
Time in closed arm before self-admin0.10.10.20.30.30.2-0.20.50.00.30.1-0.3
Time in closed arm after self-admin0.30.30.5-0.5-0.2-0.50.5-0.5-0.6-0.7-0.3-0.6
Time in open arm before self-admin0.70.81.6-1.2-1.3-1.11.0-1.1-0.7-0.4-0.10.4
Time in open arm after self-admin1.21.33.91.31.00.9-2.00.21.80.6-0.50.5
Bone: periosteal estimation2.65.510.13.03.12.4-3.21.72.81.81.00.6
Bone: periosteal perimeter1.83.04.72.22.12.0-2.01.61.91.51.00.8
Bone: post-yield work3.44.98.22.71.62.9-1.42.81.22.82.80.1
Progressive ratio test 1 active lever presses0.60.71.70.80.60.9-0.41.20.61.31.00.5
Progressive ratio test 1 breakpoint0.60.71.60.70.50.8-0.41.20.61.31.00.6
Progressive ratio test 1 inactive lever presses0.20.20.90.1-0.30.2-0.20.60.30.90.50.6
Progressive ratio test 2 active lever presses0.30.30.90.20.20.30.20.90.10.80.90.6
Progressive ratio test 2 breakpoint0.30.31.00.20.10.30.40.90.00.81.00.5
Progressive ratio test 2 inactive lever presses0.30.51.30.60.20.7-0.40.90.41.10.90.2
Incentive Sensitization - Responses0.10.10.7-0.00.3-0.00.20.30.2-0.10.30.9
Incentive Sensitization - Breakpoint0.10.10.50.10.30.10.30.40.2-0.00.40.7
Sum of active levers in priming session hrs 5-60.90.81.8-0.4-1.10.21.30.2-0.70.81.21.2
Progressive ratio0.50.81.90.4-0.30.70.31.1-0.81.31.4-1.0
Food seeking constrained by brief footshock0.91.01.8-1.2-1.3-1.01.2-0.9-1.2-0.9-0.5-0.6
Seeking ratio, punishment vs. effort0.50.71.3-0.10.6-0.4-0.4-0.81.0-1.1-1.11.1
Retroperitoneal fat weight2.811.825.63.51.44.4-0.05.1-0.54.45.0-1.5
Reaction time number correct0.20.51.4-0.7-1.0-0.41.2-0.0-0.7-0.5-0.00.6
Reaction time mean minus median0.00.10.30.30.20.3-0.30.20.00.4-0.1-0.5
Reaction time mean minus median AUC0.20.40.9-0.0-0.50.30.80.6-0.90.60.6-0.9
Reaction time num false alarms1.31.84.0-1.4-1.3-1.70.2-2.0-0.4-1.6-1.8-0.2
Reaction time num false alarms AUC0.71.02.2-1.1-1.0-1.30.1-1.5-0.1-1.2-1.30.3
Reaction time trials correct on left0.20.51.4-0.7-1.0-0.41.2-0.0-0.7-0.5-0.00.6
Reaction time trials on left0.20.51.4-0.7-1.0-0.41.20.0-0.7-0.50.00.6
Reaction time mean0.30.51.50.60.40.7-0.20.80.11.20.9-0.3
Reaction time mean AUC0.20.30.90.40.20.50.00.70.11.00.80.1
Median of all reaction times0.50.72.00.70.50.8-0.21.00.21.41.20.0
Reaction time omissions0.20.31.10.0-0.20.30.70.6-0.00.50.71.1
Reaction time false alarm rate0.70.92.5-0.7-0.4-1.1-0.5-1.60.4-1.1-1.50.0
Reaction time premature initiation rate1.01.43.41.11.70.5-1.9-0.21.8-0.5-0.90.5
Reaction time premature initiations0.40.71.70.51.10.1-1.0-0.31.3-0.9-0.90.9
Std. dev. reaction times0.20.40.90.60.30.7-0.10.8-0.10.90.7-0.6
Reaction time trials completed0.20.51.4-0.7-1.0-0.41.20.0-0.7-0.50.00.6
Reaction time trials AUC0.20.31.0-0.5-0.8-0.21.00.1-0.6-0.40.10.5
Run reversals in cocaine runway, females3.03.08.61.92.71.0-2.90.12.4-0.1-0.9-0.1
Run reversals in cocaine runway, males0.70.71.2-1.0-0.7-1.10.7-1.0-0.5-0.9-0.8-0.1
Latency to leave start box in cocaine runway0.70.81.60.1-0.30.50.81.0-1.20.81.3-1.2
Latency to leave start box in cocaine runway, F0.20.20.5-0.0-0.40.30.50.7-0.40.10.60.2
Latency to leave start box in cocaine runway, M1.11.03.50.2-0.10.50.70.8-1.31.01.2-1.9
Std. dev. time between licks in bursts0.30.40.80.5-0.10.7-0.30.80.50.80.50.9
Total sessions with >9 infusions4.85.89.53.12.82.9-2.12.91.92.52.0-0.1
Short access day 1 total inactive lever presses0.40.51.00.70.90.6-0.70.50.71.00.70.2
Short access day 10 total inactive lever presses0.71.63.5-1.8-1.1-1.90.8-1.8-0.5-1.1-1.00.5
Short access day 1 total infusions1.11.52.51.51.61.2-1.21.31.21.21.10.1
Short access day 10 total infusions2.22.84.22.12.01.9-1.51.81.61.91.30.4
Short access total infusions2.73.46.02.42.32.2-1.72.31.51.71.3-0.2
Short access day 1 locomotion0.30.41.30.61.10.3-0.70.30.50.50.4-0.5
Short access day 10 total locomotion1.73.15.02.21.82.0-2.11.71.91.90.90.4
Short access total locomotion3.54.26.82.51.92.6-1.42.60.92.62.0-1.0
One hour access (0.3 mA shock)0.30.31.00.4-0.20.70.30.9-0.21.00.80.0
Compulsive drug intake0.30.40.90.3-0.60.70.40.7-0.30.71.00.4
One hour access (shock baseline)0.10.10.4-0.3-0.5-0.20.30.0-0.5-0.0-0.2-0.6
Social response proportion0.50.61.10.2-0.60.70.91.1-0.90.71.1-0.3
Social responses0.50.61.6-0.6-1.3-0.11.20.3-0.90.70.80.5
Social time0.60.82.0-1.0-1.2-0.61.4-0.3-1.3-0.10.5-0.3
Soleus weight1.44.18.02.82.72.4-2.71.71.61.00.4-1.5
Bone: stiffness1.62.67.42.02.31.3-2.70.61.90.60.1-0.7
Tibialis anterior weight4.314.730.45.15.54.1-5.22.74.12.51.0-0.7
Time to tail flick, vehicle, before self-admin0.20.20.40.30.20.3-0.60.10.2-0.6-0.6-0.3
Time to tail flick, vehicle, after self-admin1.31.74.6-1.7-1.6-1.32.1-0.6-1.3-0.80.01.0
Time to tail flick, test, before self-admin0.30.30.7-0.20.1-0.4-0.6-0.80.6-0.5-0.80.4
Time to tail flick, test, after self-admin2.02.15.5-0.70.1-1.1-0.6-1.91.2-1.8-2.31.8
Delta time to tail flick, vehicle, before/after SA0.30.31.1-0.3-0.50.01.00.4-0.60.20.60.4
Delta time to tail flick, test, before/after SA0.20.20.40.30.50.2-0.5-0.30.7-0.2-0.60.6
Tibia length0.10.31.60.1-0.30.20.00.3-0.70.50.5-1.3
Ambulatory time before self-admin0.20.32.1-0.40.2-0.6-0.1-0.2-0.5-0.0-0.3-1.4
Ambulatory time after self-admin1.11.34.11.01.70.3-2.0-0.11.6-0.1-1.0-0.5
Bone: tissue strength0.10.10.40.00.6-0.2-0.6-0.50.5-0.0-0.0-0.0
Total heroin consumption0.70.91.9-0.2-0.80.31.21.4-0.80.91.40.6
Bone: trabecular number0.40.71.31.11.00.9-1.20.60.70.60.4-0.5
Bone: trabecular spacing0.40.62.4-0.8-0.9-0.51.0-0.1-0.2-0.2-0.11.6
Bone: trabecular thickness2.73.37.02.00.92.2-0.82.1-0.52.02.0-2.6
Bone: trabecular tissue density0.10.10.4-0.2-0.2-0.3-0.1-0.3-0.2-0.3-0.3-0.7
Water consumed over 24 hours2.53.49.6-1.3-0.2-2.0-0.5-2.41.0-2.6-3.11.2
Number of responses in last shaping day0.30.30.60.30.50.1-0.60.10.80.70.70.6