Hub : Genes

Gde1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	IC	gene expression	Gde1	0.07	0.05	3.3e-03	0.05	0.05	0.01	0.04	5.3e-03	3.1e-03	1.1e-01	6.4e-03
2	pVTA	gene expression	Gde1	0.06	0.04	2.5e-04	0.05	0.05	0.05	0.05	6.8e-05	6.5e-05	4.2e-05	3.8e-05
3	Brain	gene expression	Gde1	0.19	0.08	1.1e-14	0.11	0.14	0.14	0.14	3.0e-10	9.8e-13	1.4e-12	1.1e-12
4	Liver	gene expression	Gde1	0.39	0.15	0.0e+00	0.14	0.19	0.18	0.19	1.4e-15	1.6e-20	4.0e-20	6.8e-21
5	BLA	gene expression	Gde1	0.1	0.06	2.5e-03	0.03	0.02	0.01	0.02	1.1e-02	3.1e-02	6.4e-02	3.1e-02
6	Liver	mRNA stability	Gde1	0.04	0.02	1.9e-04	0.01	0.02	0.01	0.01	2.4e-02	5.8e-03	8.2e-03	1.7e-02
7	NAcc	gene expression	Gde1	0.08	0.04	1.6e-09	0.06	0.06	0.06	0.06	1.3e-09	2.7e-09	2.1e-09	1.9e-09
8	PL	gene expression	Gde1	0.16	0.09	1.7e-08	0.08	0.07	0.08	0.07	1.2e-08	3.8e-08	9.3e-09	3.4e-08
9	Adipose	mRNA stability	Gde1	0.03	0.02	7.5e-03	0	0.01	0.01	0.01	7.3e-02	1.7e-02	7.0e-02	2.2e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9
Bone: apparent density	0.8	1.4	2.6	1.6	1.3	1.5	-1.2	-1.2	0.7	-1.2	-1.0	-0.7
Area under the delay curve	0.2	0.3	0.6	-0.6	-0.1	-0.8	0.4	0.8	-0.5	0.6	0.5	-0.7
BMI with tail	2.9	10.2	18.6	4.3	3.6	4.1	-3.6	-3.3	3.1	-2.8	-1.5	0.4
BMI without tail	2.9	15.4	26.9	5.2	4.2	5.0	-4.0	-4.2	3.1	-4.1	-2.9	-0.5
Body weight	2.2	9.7	16.6	4.1	3.6	3.9	-3.0	-3.4	2.4	-3.2	-2.6	-0.2
Weight adjusted by age	0.3	1.0	2.4	0.8	0.4	1.0	-0.5	-0.8	0.8	-1.4	-1.1	1.5
Bone surface	0.8	1.5	2.9	1.5	1.7	1.2	-1.7	-0.7	1.5	-1.0	-0.5	0.3
Bone volume	1.1	2.3	3.9	2.0	1.9	1.7	-1.9	-1.2	1.5	-1.3	-0.8	-0.3
Breakpoint value in progressive ratio session	0.5	0.9	2.8	-1.1	-1.3	-0.6	1.7	0.3	-1.2	0.7	-0.2	0.5
Number of licking bursts	2.1	6.5	10.7	-3.2	-2.6	-3.3	1.7	3.1	-1.3	3.0	2.9	0.2
Context. condit. distance diff. score	0.2	0.2	0.7	-0.4	-0.5	-0.2	0.9	-0.1	-0.6	-0.2	-0.5	0.3
Locomotion velocity, session 1	0.2	0.2	0.6	-0.2	0.3	-0.4	-0.3	0.7	0.2	0.7	0.8	-0.4
Locomotion distance, session 1	0.9	1.2	2.0	1.3	0.9	1.4	-0.7	-1.4	0.5	-1.2	-1.4	-0.2
Locomotion velocity, session 2	0.2	0.3	0.6	-0.5	-0.0	-0.7	0.1	0.8	-0.3	0.7	0.6	-0.5
Locomotion distance, session 2	1.1	1.6	3.3	1.7	1.8	1.4	-1.7	-0.9	1.4	-0.7	-0.3	-0.2
Locomotion velocity, session 3	0.3	0.3	0.9	0.7	1.0	0.6	-0.5	-0.5	0.6	-0.3	-0.4	0.1
Locomotion distance, session 3	0.7	0.8	1.7	0.2	0.8	-0.2	-0.9	0.6	1.3	0.9	1.1	1.1
Stereotopy head waving bouts, day 3	0.4	0.5	1.4	-0.7	-1.0	-0.3	1.1	0.0	-1.2	-0.0	-0.5	-0.5
Stereotopy head waving duration, day 3	0.4	0.5	1.4	-0.2	-0.6	0.1	0.8	-0.5	-1.0	-0.8	-1.2	-0.6
Locomotion velocity, session 7	1.6	1.8	4.9	1.1	2.2	0.6	-1.6	-0.2	2.1	0.1	0.4	1.6
Locomotion distance, session 7	0.7	0.9	1.9	-0.3	0.5	-0.7	-0.8	1.0	1.1	1.1	1.4	1.2
Stereotopy head waving bouts, day 7	0.3	0.4	1.0	0.5	0.4	0.7	0.2	-0.8	-0.2	-1.0	-1.0	-0.3
Stereotopy head waving duration, day 7	1.9	2.3	3.9	1.8	1.6	1.9	-0.9	-1.8	0.9	-2.0	-1.7	0.1
Locomotion velocity, session 8	0.0	0.0	0.1	0.1	0.2	0.0	0.0	0.0	-0.1	0.2	0.0	-0.3
Locomotion distance, session 8	0.2	0.2	0.4	0.6	0.7	0.6	-0.4	-0.5	0.4	-0.3	-0.3	0.2
Degree of sensitization distance	0.6	0.6	1.6	-0.3	-0.8	0.0	0.7	-0.3	-1.2	-0.6	-0.7	-1.2
Degree of sensitization stereotypy	1.2	1.3	2.7	1.5	1.7	1.3	-1.1	-1.1	1.0	-1.1	-0.8	0.0
Conditioned locomotion	0.8	0.9	2.3	-0.9	-0.2	-1.1	0.4	1.1	0.4	1.2	1.1	1.5
Cocaine response after cond. corrected	0.2	0.3	0.5	-0.6	-0.5	-0.7	0.3	0.7	-0.3	0.7	0.7	-0.1
Cocaine response after cond. not corrected	0.1	0.1	0.2	0.2	0.4	0.0	-0.5	0.2	0.5	0.1	0.4	0.2
Cocaine response before conditioning	1.7	2.0	4.9	1.7	2.2	1.2	-1.9	-0.7	2.0	-0.7	-0.1	0.7
Saline control response	0.2	0.3	0.7	-0.2	-0.8	0.0	0.6	-0.3	-0.8	-0.3	-0.6	-0.5
Bone: connectivity density	0.6	1.0	1.7	1.3	1.0	1.3	-1.0	-1.0	0.9	-1.1	-0.8	0.3
Bone: cortical apparent density	0.9	1.4	2.3	-1.5	-1.4	-1.5	0.9	1.4	-0.9	1.2	0.9	-0.3
Bone: cortical area	2.0	3.2	6.2	2.4	2.5	1.9	-2.5	-1.3	1.8	-1.2	-0.7	-0.5
Bone: cortical porosity	1.2	1.3	2.2	1.3	1.3	1.5	-0.5	-1.5	0.7	-1.1	-1.2	0.5
Bone: cortical porosity	0.8	0.9	2.0	0.9	0.8	1.2	0.1	-1.4	0.3	-0.9	-1.4	0.6
Bone: cortical thickness	0.6	1.0	2.4	1.2	1.5	0.8	-1.5	-0.3	0.7	-0.2	0.1	-1.5
Bone: cortical thickness	0.6	0.8	3.6	0.2	0.5	-0.1	-0.7	0.5	-0.2	0.9	1.2	-1.9
Bone: cortical tissue density	0.8	1.3	2.2	-1.5	-1.5	-1.5	0.9	1.3	-0.9	1.2	0.8	-0.3
Condit. Reinf. active minus inactive responses	0.1	0.2	0.4	-0.1	-0.3	0.2	0.6	-0.4	-0.5	-0.3	-0.6	0.0
Condit. Reinf. active-inactive response ratio	0.3	0.3	0.9	0.2	0.1	0.5	0.4	-0.7	-0.0	-0.7	-1.0	0.6
Condit. Reinf. active responses	0.1	0.1	0.4	-0.2	-0.4	0.1	0.6	-0.3	-0.6	-0.0	-0.2	-0.3
Condit. Reinf. inactive responses	0.1	0.1	0.4	-0.1	-0.4	0.0	0.1	-0.1	-0.4	0.3	0.3	-0.6
Incentive salience index mean	0.1	0.1	0.6	0.2	0.4	0.3	-0.2	-0.2	0.5	-0.1	0.0	0.8
Condit. Reinf. lever presses	0.2	0.4	1.9	0.0	0.3	-0.0	-0.3	0.1	0.8	0.3	0.6	1.4
Condit. Reinf. active minus inactive responses	1.5	2.3	5.2	1.4	0.0	1.9	-0.1	-2.3	-0.3	-2.0	-2.3	-0.5
Condit. Reinf. active-inactive response ratio	0.9	1.5	3.7	0.6	-0.8	1.2	0.6	-1.7	-1.0	-1.5	-1.9	-0.7
Condit. Reinf. active responses	1.1	1.6	3.5	1.3	0.3	1.6	-0.4	-1.9	0.1	-1.7	-1.9	-0.1
Condit. Reinf. inactive responses	0.7	1.0	2.5	1.1	1.6	0.7	-1.4	-0.3	1.6	-0.4	0.0	0.8
Condit. Reinf. lever presses	1.8	2.6	5.0	1.9	0.9	2.1	-1.0	-2.2	0.7	-2.1	-1.9	0.0
Condit. Reinf. lever reinforcers received	1.0	1.4	3.6	1.0	-0.0	1.4	0.0	-1.7	-0.2	-1.6	-1.9	0.0
Conditioned reinforcement - actives	0.0	0.2	1.3	0.1	0.2	-0.1	0.1	-0.1	-0.3	0.1	-0.0	-1.1
Conditioned reinforcement - inactives	0.3	0.9	1.7	-1.2	-1.2	-1.3	0.6	1.0	-0.9	0.6	0.7	-1.0
Conditioned locomotion	0.0	0.1	0.2	-0.4	-0.2	-0.5	0.2	0.3	-0.2	0.0	0.1	-0.3
Patch foraging indifference point 0 sec	0.5	1.4	3.0	1.0	-0.1	1.4	0.1	-1.6	-0.8	-1.5	-1.7	-1.3
Patch foraging indifference point AUC	0.2	0.4	1.3	0.7	0.3	0.6	-1.0	-0.4	0.2	-0.7	-0.1	-1.1
Delay disc. indifference point, 0s delay	0.9	1.0	2.7	0.4	1.1	-0.2	-1.6	0.9	1.2	0.8	1.5	-0.2
Delay disc. indifference point, 16s delay	2.4	3.5	6.6	-2.3	-2.5	-1.8	2.6	1.2	-2.4	1.3	0.3	-0.8
Delay disc. indifference point, 2s delay	2.4	2.7	6.3	2.1	2.5	1.5	-2.5	-0.7	2.1	-0.6	0.3	-0.1
Delay disc. indifference point, 24s delay	1.7	2.8	5.2	-2.3	-1.6	-2.1	2.1	1.6	-1.7	1.5	0.8	-0.1
Delay disc. indifference point, 4s delay	0.4	0.4	1.8	-0.2	0.6	-0.5	-0.3	0.7	-0.3	0.7	0.8	-1.3
Delay disc. indifference point, 8s delay	0.1	0.2	0.4	-0.2	0.6	-0.5	-0.3	0.7	0.2	0.4	0.5	-0.3
Indifference point function ln k	0.0	0.1	0.2	0.4	0.4	0.4	-0.2	-0.2	0.3	0.1	0.0	-0.1
Indifference point function log k	0.0	0.1	0.2	0.4	0.4	0.4	-0.2	-0.2	0.3	0.1	0.0	-0.1
Patch foraging total patch changes 0 sec	0.6	1.9	4.0	1.1	-0.1	1.6	0.2	-1.8	-0.9	-1.8	-2.0	-1.4
Patch foraging total patch changes 12 sec	0.3	0.4	0.9	0.6	0.0	0.8	-0.4	-0.8	0.0	-1.0	-0.9	-0.1
Patch foraging total patch changes 18 sec	0.1	0.3	1.4	-0.0	-0.4	0.1	0.0	-0.1	-0.7	-0.5	-0.2	-1.2
Patch foraging total patch changes 24 sec	0.4	1.2	2.5	1.0	0.3	1.2	-0.4	-1.3	-0.3	-1.6	-1.5	-1.2
Patch foraging total patch changes 6 sec	1.4	2.3	7.9	-0.2	-1.4	0.4	1.2	-0.9	-2.4	-0.8	-1.3	-2.8
Patch foraging time to switch 0 sec	0.6	2.4	5.6	-1.9	-0.9	-1.9	1.2	1.8	0.0	1.5	1.2	2.4
Patch foraging water rate 0 sec	0.1	0.4	0.9	0.8	0.3	0.9	-0.5	-0.9	0.2	-0.8	-0.6	-0.3
Patch foraging water rate 12 sec	0.4	1.7	3.0	1.4	0.8	1.6	-0.4	-1.7	-0.3	-1.5	-1.5	-1.6
Patch foraging water rate 18 sec	0.4	1.0	2.2	0.9	0.3	1.2	0.2	-1.5	-0.3	-1.1	-1.4	-0.6
Patch foraging water rate 24 sec	0.2	0.3	1.1	0.7	0.5	0.5	-0.6	-0.4	0.2	-0.3	-0.2	-1.0
Patch foraging water rate 6 sec	0.4	0.5	3.3	-0.1	-0.6	-0.1	0.3	0.0	-0.9	-0.4	-0.2	-1.8
Seeking ratio, delayed vs. immediate footshock	0.1	0.1	0.2	0.3	0.1	0.3	-0.2	-0.5	-0.0	-0.3	-0.3	-0.2
Distance traveled before self-admin	0.1	0.2	0.8	0.1	0.7	-0.1	-0.5	-0.1	0.1	-0.1	0.3	-0.9
Distance traveled after self-admin	0.8	1.4	4.3	1.1	1.7	0.5	-2.1	-0.1	1.7	-0.2	0.8	-0.2
Extensor digitorum longus weight	3.2	12.6	30.3	4.1	5.5	2.8	-5.4	-1.2	5.0	-1.3	0.2	1.2
Bone: elastic displacement	0.6	0.7	2.0	-0.7	-0.8	-0.5	1.2	0.2	-1.4	0.2	0.0	-1.2
Bone: elastic work	0.2	0.3	0.7	0.6	0.8	0.5	-0.6	-0.3	0.2	-0.3	-0.2	-0.7
Bone: endosteal estimation	1.4	3.5	5.4	2.2	2.1	1.9	-2.2	-1.3	2.3	-1.8	-1.1	1.3
Bone: endosteal perimeter	0.8	2.0	5.1	1.5	1.7	1.0	-2.0	-0.5	2.2	-0.6	0.1	1.5
Epididymis fat weight	0.7	3.6	6.2	2.4	1.6	2.5	-1.3	-2.4	0.8	-2.3	-2.1	-0.6
Delta time in closed arm before/after self-admin	1.0	1.0	2.8	0.3	0.7	-0.1	-1.1	0.7	1.5	0.8	1.0	1.7
Delta time in open arm before/after self-admin	1.0	1.2	2.3	1.5	0.8	1.5	-1.1	-1.3	0.5	-1.1	-0.5	-0.7
Diff in mean of infusions in LGA sessions	0.6	1.0	2.5	-0.2	-1.2	0.3	1.1	-0.6	-1.6	-0.9	-0.9	-1.5
Delay discount exponential model param	0.3	0.4	0.7	0.7	0.1	0.8	-0.4	-0.9	0.5	-0.7	-0.5	0.6
Extinction: sum of active levers before priming	0.3	0.4	1.0	-0.7	-1.0	-0.5	0.7	0.4	-0.4	0.5	0.5	0.6
Active lever presses in extinction session 6	0.2	0.2	0.8	0.3	-0.1	0.5	0.3	-0.9	-0.3	-0.7	-0.5	-0.0
Bone: final force	3.2	5.3	9.9	3.0	3.1	2.5	-3.1	-1.7	2.4	-1.8	-1.0	-0.5
Bone: final moment	3.0	4.9	8.4	2.9	2.8	2.5	-2.8	-1.9	2.0	-2.0	-1.3	-0.6
Food consumed during 24 hour testing period	0.6	1.1	3.3	1.4	1.1	1.0	-1.8	-0.5	1.3	-0.7	0.0	-0.3
Glucose	0.1	0.1	0.3	-0.2	-0.0	-0.1	0.3	0.1	-0.5	0.1	-0.1	-0.6
Heart weight	0.0	0.1	0.1	0.3	0.0	0.3	-0.4	-0.2	0.1	-0.3	-0.2	-0.4
Delay discount hyperbolic model param	0.1	0.1	0.3	0.3	-0.3	0.4	-0.1	-0.5	0.2	-0.4	-0.4	0.5
Intermittent access intake day 1-15 change	0.3	1.6	3.4	-1.4	-0.6	-1.8	0.1	1.8	-0.1	1.5	1.8	-0.2
Intermittent access intake escalation	0.3	1.7	3.4	-1.5	-0.7	-1.8	0.3	1.8	-0.4	1.6	1.8	-0.5
Intermittent access intake escalation 2	1.5	2.5	5.4	-1.6	-0.7	-2.0	0.2	2.1	-0.2	2.3	2.3	-0.3
Intermitt. access day 1 inactive lever presses	0.1	0.6	1.5	-1.0	-1.1	-1.1	0.2	1.2	-0.4	0.4	0.7	-0.3
Intermitt. access day 15 inactive lever presses	0.0	0.2	0.8	0.4	0.4	0.1	-0.9	0.1	0.8	0.1	0.6	0.2
Intermitt. access escalation Index	0.1	0.4	1.2	0.7	-0.0	0.8	-0.4	-0.7	0.1	-1.1	-0.7	-0.2
Intermittent access day 1 total infusions	0.3	1.0	2.2	1.2	0.5	1.3	-0.5	-1.5	0.4	-1.3	-1.1	-0.0
Intermittent access day 15 total infusions	0.0	0.1	0.3	-0.2	-0.2	-0.3	-0.0	0.2	-0.1	0.2	0.6	-0.4
Intermittent access terminal intake (last 3 days)	0.0	0.1	0.2	0.3	0.1	0.2	-0.2	-0.4	0.1	-0.1	0.2	-0.4
Intermittent access total infusions	0.7	0.8	1.6	1.2	0.9	1.1	-0.8	-1.2	0.5	-0.9	-0.5	-0.6
Intermittent access day 1 locomotion	0.4	0.7	1.9	0.8	0.0	0.9	-0.1	-1.3	-0.1	-1.4	-1.2	-0.5
Intermittent access day 15 total locomotion	0.1	0.5	1.4	-0.2	-0.8	0.0	0.8	-0.4	-1.1	-0.6	-0.4	-1.2
Intermittent access total locomotion	0.8	0.9	2.3	0.8	-0.1	1.1	0.1	-1.4	-0.4	-1.5	-1.2	-0.9
Intermittent access standard deviation	0.2	1.2	3.3	0.7	1.2	0.0	-1.8	0.4	1.4	0.7	1.7	-0.4
Left kidney weight	0.8	6.8	11.9	3.5	3.4	2.9	-3.3	-2.2	2.6	-2.1	-1.3	-0.5
Right kidney weight	1.2	8.4	15.5	3.9	3.6	3.6	-3.3	-3.0	2.4	-2.4	-1.5	-0.9
Cocaine induced anxiety	0.1	0.2	0.5	-0.6	-0.5	-0.6	0.0	0.7	-0.0	-0.0	0.5	0.2
Post-drug Anxiety	0.6	0.6	1.5	-0.8	-1.0	-0.5	0.9	0.3	-1.2	-0.3	-0.3	-1.1
Baseline Anxiety	0.3	0.6	2.3	0.4	0.2	0.4	0.3	-0.9	-0.8	-0.4	-0.9	-1.5
Tail length	0.4	1.9	3.0	1.7	1.7	1.5	-1.1	-1.3	0.6	-1.5	-1.6	-1.2
Length with tail	0.2	0.7	2.4	0.7	0.9	0.7	0.1	-0.9	-0.1	-0.9	-1.5	-0.6
Length without tail	0.2	0.9	2.0	-1.2	-0.6	-1.2	1.4	0.7	-1.0	1.1	0.2	-0.0
Times rat made contact with spout	1.4	1.6	4.4	0.8	1.3	0.1	-2.1	0.6	2.0	0.5	1.6	0.6
Lifetime Intake	1.0	1.3	2.4	1.5	1.3	1.4	-1.0	-1.5	0.7	-1.0	-0.7	-0.5
Liver weight, left	0.5	0.8	2.6	-0.1	-1.0	0.4	0.8	-0.9	-0.4	-1.0	-1.6	1.0
Liver weight, right	0.2	0.4	2.5	0.0	-0.3	0.2	0.5	-0.5	0.3	0.1	-0.4	1.6
Locomotor activity	0.1	0.2	0.5	0.3	-0.3	0.5	0.1	-0.6	0.0	-0.6	-0.7	0.4
Locomotor testing distance	0.1	0.3	0.6	0.6	-0.0	0.8	-0.2	-0.8	0.1	-0.7	-0.7	-0.0
Locomotor testing rearing	0.1	0.5	1.9	0.2	-0.5	0.6	0.7	-0.9	-0.4	-0.9	-1.4	0.4
Locomotion in novel chamber	1.2	1.7	3.7	1.2	0.4	1.7	0.2	-1.9	-0.3	-1.8	-1.8	-0.4
Locomotion in novel chamber post-restriction	0.5	1.4	2.6	-0.1	-1.4	0.5	1.4	-1.1	-1.6	-1.2	-1.3	-1.1
Fecal boli incidents, locomotor time 1	0.2	0.5	2.5	-0.3	-0.2	-0.1	1.0	-0.5	0.1	-0.3	-0.6	1.6
Change in fecal boli incidents, locomotor task	1.2	1.2	4.5	0.9	0.6	1.1	-0.0	-1.3	-0.9	-0.8	-1.1	-2.1
Time >=10cm from walls, locomotor time 1	0.3	0.3	1.0	0.5	1.0	0.3	-0.9	-0.3	0.8	-0.1	0.3	-0.0
Bouts of movement, locomotor time 1	1.6	2.0	4.3	-2.0	-2.1	-1.5	1.8	0.8	-1.6	0.9	0.4	0.3
Total resting periods, locomotor time 1	2.0	2.3	4.4	-2.1	-2.0	-1.7	2.0	1.0	-1.6	1.2	0.5	0.5
Rest time, locomotor task time 1	0.8	1.4	2.8	-1.5	-0.1	-1.6	0.7	1.3	-0.1	1.7	1.1	1.0
Distance moved, locomotor task time 1	0.6	1.7	3.8	1.5	0.6	1.7	-0.9	-1.4	0.1	-1.9	-1.5	-1.0
Vertical activity count, locomotor time 1	0.2	1.5	3.6	1.5	0.9	1.2	-1.9	-0.6	0.7	-1.3	-0.3	-1.6
Time >=10cm from walls, locomotor time 2	0.4	1.2	3.0	1.3	1.7	0.8	-1.7	-0.3	1.6	0.1	0.5	0.1
Bouts of movement, locomotor time 2	0.4	1.4	5.4	0.8	0.7	0.8	-0.6	-1.0	1.4	-1.1	-0.8	2.3
Total resting periods, locomotor time 2	0.4	1.5	4.9	0.9	1.0	1.0	-0.8	-1.1	1.5	-1.1	-0.9	2.2
Rest time, locomotor task time 2	0.1	0.1	0.4	0.1	0.7	0.1	0.3	-0.4	-0.2	-0.2	-0.5	-0.3
Distance moved, locomotor task time 2	0.5	0.7	2.0	0.1	0.5	-0.4	-1.4	1.1	0.8	0.7	1.3	-0.3
Vertical activity count, locomotor time 2	0.2	0.6	2.1	0.0	-0.0	-0.4	-1.1	0.9	0.1	0.3	0.8	-1.4
Light reinforcement 1	0.1	0.7	1.7	0.0	-0.7	0.5	0.9	-1.0	-0.9	-1.0	-1.3	-0.1
Light reinforcement 2	0.3	0.7	1.8	0.3	-0.6	0.7	0.6	-1.2	-0.7	-1.1	-1.3	-0.3
Bone: marrow area	1.2	3.1	4.9	2.1	2.0	1.8	-2.1	-1.2	2.2	-1.7	-1.1	1.2
Bone: maximum diameter	1.8	3.5	5.8	2.4	2.2	2.1	-2.4	-1.6	2.0	-1.8	-1.1	0.3
Bone: maximum force	2.3	4.6	9.2	2.8	3.0	2.3	-3.0	-1.5	2.3	-1.6	-0.9	-0.5
Bone: maximum moment	2.2	4.1	7.0	2.6	2.6	2.2	-2.6	-1.6	1.9	-1.8	-1.2	-0.6
Mean time between licks in bursts	0.0	0.1	0.5	-0.5	-0.3	-0.4	0.3	0.2	-0.1	0.2	0.2	0.7
Mean num. licks in bursts	2.3	6.1	10.7	3.3	3.0	2.9	-2.8	-2.3	2.3	-2.3	-1.6	-0.1
Cd content in liver	3.0	3.4	8.1	-0.1	-1.5	0.9	2.2	-1.9	-2.3	-2.0	-2.8	-1.2
Co content in liver	0.7	0.8	5.1	-0.3	-0.3	-0.4	0.2	0.4	-1.1	0.4	0.6	-2.2
Cu content in liver	0.7	0.9	1.5	1.1	0.9	1.2	-0.6	-1.2	-0.0	-0.9	-0.6	-1.2
Fe content in liver	0.5	0.6	2.4	-0.6	-0.4	-0.5	0.7	0.3	-1.2	0.6	0.4	-1.5
K content in liver	0.2	0.2	0.5	0.6	0.3	0.7	-0.3	-0.7	0.1	-0.6	-0.3	-0.2
Mg content in liver	0.3	0.4	0.7	0.5	0.5	0.6	-0.2	-0.7	0.5	-0.8	-0.6	0.8
Mn content in liver	0.4	0.4	0.9	0.7	0.9	0.5	-0.9	-0.3	0.9	-0.2	0.1	0.5
Na content in liver	3.2	3.6	8.7	2.1	2.4	1.5	-2.8	-0.6	3.0	-0.7	0.4	1.6
Rb content in liver	3.4	4.0	11.3	-0.8	-1.5	0.1	2.6	-1.2	-3.4	-1.0	-2.1	-2.8
Se content in liver	0.2	0.2	0.5	0.2	0.6	-0.1	-0.7	0.4	0.7	0.3	0.7	0.2
Sr content in liver	0.6	0.5	1.0	0.9	0.5	0.8	-1.0	-0.5	1.0	-0.5	-0.1	0.6
Zn content in liver	2.4	2.8	5.2	1.9	1.3	2.0	-1.4	-1.9	1.3	-2.3	-1.7	0.9
Bone: minimum diameter	1.6	3.1	5.7	2.1	2.4	1.7	-2.3	-1.2	2.3	-1.2	-0.6	0.9
Time in familiar zone, hab. session 1	0.8	0.9	2.8	-0.8	-1.1	-0.7	0.9	0.5	-1.4	0.3	0.3	-1.7
Time in novel zone, hab. session 1	1.1	1.3	3.6	1.0	1.6	0.8	-0.7	-0.7	1.6	-0.1	-0.4	1.9
Total zone transitions, hab. session 1	1.6	2.2	4.1	2.0	2.0	1.8	-1.7	-1.4	0.9	-1.1	-0.6	-1.3
Total locomotion distance, hab. session 1	4.0	5.7	10.4	3.2	2.5	3.1	-2.4	-2.6	1.3	-2.3	-1.8	-1.5
Locomotion velocity, hab. session 1	3.7	5.2	9.0	3.0	1.9	3.0	-2.0	-2.7	1.0	-2.6	-2.1	-1.4
Time in familiar zone, hab. session 2	0.3	0.3	0.7	0.6	0.5	0.5	-0.6	-0.3	0.3	-0.8	-0.5	-0.5
Time in novel zone, hab. session 2	0.0	0.1	0.2	-0.0	-0.1	0.1	0.4	-0.3	-0.2	0.0	-0.3	0.2
Total zone transitions, hab. session 2	1.6	2.1	3.9	2.0	1.7	1.9	-1.3	-1.6	0.7	-1.2	-1.0	-1.0
Total locomotion distance, hab. session 2	2.0	2.6	5.0	2.2	1.8	2.0	-1.8	-1.6	0.9	-1.4	-1.0	-1.3
Locomotion velocity, hab. session 2	2.4	3.2	6.1	2.5	2.0	2.2	-2.1	-1.8	1.2	-1.5	-1.0	-1.1
Novel to familiar place preference ratio	1.0	1.3	2.3	-1.2	-1.5	-1.1	0.7	1.0	-1.0	1.5	1.4	-0.7
Novelty place preference	1.3	1.7	3.1	-1.3	-1.4	-1.3	0.6	1.3	-0.9	1.8	1.7	-0.8
Time in novel zone, NPP test	1.0	1.2	1.9	-1.1	-1.4	-1.0	0.7	0.9	-1.1	1.4	1.3	-0.9
Total zone transitions, NPP test	1.0	1.5	2.8	1.7	1.6	1.5	-1.4	-1.2	0.9	-0.9	-0.6	-0.6
Total locomotion distance, NPP test	0.9	1.3	2.6	1.5	1.2	1.3	-1.6	-1.0	0.8	-0.7	-0.4	-1.1
Locomotion velocity, NPP test	0.7	1.0	2.3	1.4	1.1	1.1	-1.5	-0.8	0.7	-0.5	-0.2	-1.1
Intraocular pressure	0.2	0.3	0.5	0.6	0.7	0.5	-0.5	-0.4	0.7	0.0	-0.2	0.7
Delta distance traveled before/after self-admin	0.5	0.6	1.3	0.9	1.0	0.7	-0.9	-0.4	1.2	-0.5	-0.1	0.8
Delta ambulatory time before/after self-admin	0.5	0.9	2.2	1.0	1.2	0.7	-1.4	-0.1	1.5	0.0	0.5	0.7
Parametrial fat weight	3.3	7.8	13.6	3.2	2.1	3.6	-1.0	-3.7	0.1	-3.6	-3.4	-1.9
Pavlov. Cond. lever latency	1.4	1.8	8.8	-0.8	-0.9	-0.8	0.9	0.7	-1.9	0.8	0.4	-3.0
Pavlov. Cond. magazine entry latency	3.8	4.9	8.4	2.4	2.0	2.3	-2.1	-2.0	2.8	-1.8	-1.0	2.9
Pavlov. Cond. change in total contacts	2.4	2.5	10.4	0.8	1.3	0.4	-1.7	-0.1	2.6	-0.0	0.5	3.2
Pavlov. Cond. index score	2.4	3.0	10.4	1.4	1.3	1.4	-1.4	-1.3	2.4	-1.2	-0.6	3.2
Pavlov. Cond. latency score	2.1	2.7	8.4	1.4	1.3	1.4	-1.3	-1.3	2.2	-1.2	-0.7	2.9
Pavlov. Cond. lever contacts	2.6	3.1	9.5	1.5	1.6	1.4	-1.5	-1.2	2.5	-1.2	-0.7	3.1
Pavlov. Cond. magazine entry number	2.2	2.9	9.1	-1.4	-1.5	-1.2	1.7	1.0	-2.5	0.8	0.2	-3.0
Pavlov. Cond. intertrial magazine entries	1.6	1.9	5.1	-1.0	-1.7	-0.6	1.7	0.1	-2.3	0.4	-0.4	-2.1
Pavlov. Cond. lever-magazine prob. diff.	2.9	3.6	10.8	1.7	1.5	1.6	-1.6	-1.4	2.6	-1.4	-0.8	3.3
Pavlov. Cond. response bias	2.8	3.5	12.4	1.4	1.7	1.2	-1.8	-0.8	2.9	-0.7	-0.0	3.5
Pavlov. Cond. lever latency	1.3	1.9	3.3	-1.6	-0.9	-1.7	0.8	1.8	-0.7	1.8	1.7	0.0
Pavlov. Cond. magazine entry latency	0.6	0.8	1.7	-1.0	-0.9	-1.0	0.7	0.8	0.0	0.9	0.7	1.3
Pavlov. Cond. change in total contacts	0.7	1.7	4.7	0.5	-0.7	1.1	0.8	-1.7	-1.2	-1.6	-2.2	-1.1
Pavlov. Cond. index score	0.2	0.3	0.7	0.3	-0.3	0.5	0.2	-0.8	-0.0	-0.8	-0.9	0.3
Pavlov. Cond. latency score	0.1	0.2	0.4	0.3	-0.2	0.4	0.0	-0.6	0.2	-0.6	-0.6	0.5
Pavlov. Cond. lever contacts	1.3	1.9	3.5	1.6	0.9	1.7	-0.8	-1.8	0.7	-1.9	-1.7	0.2
Pavlov. Cond. magazine entry number	1.0	1.3	3.1	1.5	1.8	1.2	-1.5	-0.7	1.1	-0.9	-0.3	-0.5
Pavlov. Cond. intertrial magazine entries	1.5	3.3	5.4	2.3	2.0	2.2	-1.8	-1.9	1.6	-1.9	-1.5	0.3
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.2	0.4	0.1	-0.5	0.3	0.3	-0.6	-0.0	-0.5	-0.7	0.5
Pavlov. Cond. response bias	0.5	0.7	1.6	0.7	-0.1	0.9	0.0	-1.2	0.0	-1.2	-1.3	0.2
Time in closed arm before self-admin	0.0	0.1	0.2	0.3	0.3	0.2	-0.2	-0.5	0.0	-0.3	-0.1	-0.3
Time in closed arm after self-admin	0.2	0.3	0.5	-0.5	-0.2	-0.5	0.5	0.5	-0.6	0.7	0.3	-0.6
Time in open arm before self-admin	0.7	0.8	1.6	-1.2	-1.3	-1.1	1.0	1.1	-0.7	0.4	0.1	0.4
Time in open arm after self-admin	1.2	1.3	3.9	1.3	1.0	0.9	-2.0	-0.2	1.8	-0.6	0.5	0.5
Bone: periosteal estimation	2.3	5.5	10.1	3.0	3.1	2.4	-3.2	-1.7	2.8	-1.8	-1.0	0.6
Bone: periosteal perimeter	1.5	3.0	4.7	2.2	2.1	2.0	-2.0	-1.6	1.9	-1.5	-1.0	0.8
Bone: post-yield work	2.9	4.9	8.2	2.7	1.6	2.9	-1.4	-2.8	1.2	-2.8	-2.8	0.1
Progressive ratio test 1 active lever presses	0.4	0.7	1.7	0.8	0.6	0.9	-0.4	-1.2	0.6	-1.3	-0.9	0.5
Progressive ratio test 1 breakpoint	0.4	0.7	1.6	0.7	0.5	0.8	-0.4	-1.2	0.6	-1.3	-0.9	0.6
Progressive ratio test 1 inactive lever presses	0.1	0.2	0.9	0.1	-0.3	0.2	-0.2	-0.6	0.3	-0.9	-0.5	0.6
Progressive ratio test 2 active lever presses	0.2	0.3	0.9	0.2	0.2	0.3	0.2	-0.9	0.1	-0.8	-0.9	0.6
Progressive ratio test 2 breakpoint	0.3	0.3	1.0	0.2	0.1	0.3	0.4	-0.9	0.0	-0.8	-1.0	0.5
Progressive ratio test 2 inactive lever presses	0.1	0.5	1.3	0.6	0.2	0.7	-0.4	-0.9	0.4	-1.1	-0.8	0.2
Incentive Sensitization - Responses	0.0	0.1	0.7	-0.0	0.3	-0.0	0.2	-0.3	0.2	0.1	-0.3	0.9
Incentive Sensitization - Breakpoint	0.1	0.1	0.5	0.1	0.3	0.1	0.3	-0.4	0.2	0.0	-0.4	0.7
Sum of active levers in priming session hrs 5-6	0.9	0.8	1.8	-0.4	-1.1	0.2	1.3	-0.2	-0.7	-0.8	-1.2	1.2
Progressive ratio	0.3	0.8	1.9	0.4	-0.3	0.7	0.3	-1.1	-0.8	-1.3	-1.4	-1.0
Food seeking constrained by brief footshock	0.8	1.0	1.8	-1.2	-1.3	-1.0	1.2	0.9	-1.2	0.9	0.5	-0.6
Seeking ratio, punishment vs. effort	0.3	0.7	1.3	-0.1	0.6	-0.4	-0.4	0.8	1.0	1.1	1.1	1.1
Retroperitoneal fat weight	2.6	11.8	25.6	3.5	1.4	4.4	-0.0	-5.1	-0.5	-4.4	-5.0	-1.5
Reaction time number correct	0.1	0.5	1.3	-0.7	-1.0	-0.4	1.2	0.0	-0.7	0.5	0.0	0.6
Reaction time mean minus median	0.0	0.1	0.3	0.3	0.2	0.3	-0.3	-0.2	0.0	-0.4	0.1	-0.5
Reaction time mean minus median AUC	0.1	0.4	0.9	-0.0	-0.5	0.3	0.8	-0.6	-0.9	-0.6	-0.6	-0.9
Reaction time num false alarms	1.1	1.8	4.0	-1.4	-1.3	-1.7	0.2	2.0	-0.4	1.6	1.8	-0.2
Reaction time num false alarms AUC	0.4	1.0	2.2	-1.1	-1.0	-1.3	0.1	1.5	-0.1	1.2	1.3	0.3
Reaction time trials correct on left	0.1	0.5	1.3	-0.7	-1.0	-0.4	1.2	0.0	-0.7	0.5	0.0	0.6
Reaction time trials on left	0.1	0.5	1.4	-0.7	-1.0	-0.4	1.2	-0.0	-0.7	0.5	-0.0	0.6
Reaction time mean	0.2	0.5	1.5	0.6	0.4	0.7	-0.2	-0.8	0.1	-1.2	-0.9	-0.3
Reaction time mean AUC	0.1	0.3	0.9	0.4	0.2	0.5	0.0	-0.7	0.1	-1.0	-0.8	0.1
Median of all reaction times	0.4	0.7	2.0	0.7	0.5	0.8	-0.2	-1.0	0.2	-1.4	-1.2	0.0
Reaction time omissions	0.2	0.3	1.1	0.0	-0.2	0.3	0.7	-0.6	-0.0	-0.5	-0.7	1.1
Reaction time false alarm rate	0.7	0.9	2.5	-0.7	-0.4	-1.1	-0.5	1.6	0.4	1.1	1.5	0.0
Reaction time premature initiation rate	0.9	1.4	3.4	1.1	1.7	0.5	-1.8	0.2	1.8	0.5	0.9	0.5
Reaction time premature initiations	0.2	0.7	1.7	0.5	1.1	0.1	-1.0	0.3	1.3	0.9	0.9	0.9
Std. dev. reaction times	0.1	0.4	0.9	0.6	0.3	0.7	-0.1	-0.8	-0.1	-0.9	-0.7	-0.6
Reaction time trials completed	0.1	0.5	1.4	-0.7	-1.0	-0.4	1.2	-0.0	-0.7	0.5	-0.0	0.6
Reaction time trials AUC	0.1	0.3	1.0	-0.5	-0.8	-0.2	1.0	-0.1	-0.6	0.4	-0.1	0.5
Run reversals in cocaine runway, females	2.7	3.0	8.6	1.9	2.7	1.0	-2.9	-0.1	2.4	0.1	0.9	-0.1
Run reversals in cocaine runway, males	0.6	0.7	1.2	-1.0	-0.7	-1.1	0.7	1.0	-0.5	0.9	0.8	-0.1
Latency to leave start box in cocaine runway	0.6	0.8	1.6	0.1	-0.3	0.5	0.8	-1.0	-1.2	-0.8	-1.3	-1.2
Latency to leave start box in cocaine runway, F	0.1	0.2	0.5	-0.0	-0.4	0.3	0.5	-0.7	-0.4	-0.1	-0.6	0.2
Latency to leave start box in cocaine runway, M	1.1	1.0	3.5	0.2	-0.1	0.5	0.7	-0.8	-1.3	-1.0	-1.3	-1.9
Std. dev. time between licks in bursts	0.2	0.4	0.8	0.5	-0.1	0.7	-0.3	-0.8	0.5	-0.8	-0.5	0.9
Total sessions with >9 infusions	4.7	5.8	9.5	3.1	2.8	2.9	-2.1	-2.9	1.9	-2.5	-2.0	-0.1
Short access day 1 total inactive lever presses	0.2	0.5	1.0	0.7	0.9	0.6	-0.7	-0.5	0.7	-1.0	-0.7	0.2
Short access day 10 total inactive lever presses	0.2	1.6	3.5	-1.8	-1.1	-1.9	0.8	1.8	-0.5	1.1	1.0	0.5
Short access day 1 total infusions	0.8	1.5	2.5	1.5	1.6	1.2	-1.2	-1.3	1.2	-1.2	-1.1	0.1
Short access day 10 total infusions	1.7	2.8	4.2	2.1	2.0	1.9	-1.5	-1.8	1.6	-1.9	-1.3	0.4
Short access total infusions	2.4	3.4	6.0	2.4	2.3	2.2	-1.7	-2.3	1.5	-1.7	-1.3	-0.2
Short access day 1 locomotion	0.2	0.4	1.3	0.6	1.1	0.3	-0.7	-0.3	0.5	-0.5	-0.4	-0.5
Short access day 10 total locomotion	0.8	3.1	5.0	2.2	1.8	2.0	-2.1	-1.7	1.9	-1.9	-0.9	0.4
Short access total locomotion	2.8	4.2	6.8	2.5	1.9	2.6	-1.4	-2.6	0.9	-2.6	-2.0	-1.0
One hour access (0.3 mA shock)	0.3	0.3	1.0	0.4	-0.2	0.7	0.2	-0.9	-0.2	-1.0	-0.8	0.0
Compulsive drug intake	0.2	0.4	0.9	0.3	-0.6	0.7	0.4	-0.7	-0.3	-0.7	-1.0	0.4
One hour access (shock baseline)	0.0	0.1	0.4	-0.3	-0.5	-0.2	0.3	-0.0	-0.5	0.0	0.2	-0.6
Social response proportion	0.4	0.6	1.1	0.2	-0.6	0.7	0.9	-1.1	-0.9	-0.7	-1.1	-0.3
Social responses	0.5	0.6	1.6	-0.6	-1.3	-0.1	1.2	-0.3	-0.9	-0.7	-0.8	0.5
Social time	0.5	0.8	2.0	-1.0	-1.2	-0.6	1.4	0.3	-1.3	0.1	-0.5	-0.3
Soleus weight	1.4	4.1	8.0	2.8	2.7	2.4	-2.7	-1.7	1.6	-1.0	-0.3	-1.5
Bone: stiffness	1.4	2.6	7.4	2.0	2.3	1.3	-2.7	-0.6	1.9	-0.6	-0.1	-0.7
Tibialis anterior weight	4.3	14.7	30.5	5.1	5.5	4.1	-5.2	-2.7	4.1	-2.5	-1.0	-0.7
Time to tail flick, vehicle, before self-admin	0.1	0.2	0.4	0.3	0.2	0.3	-0.6	-0.1	0.2	0.6	0.6	-0.3
Time to tail flick, vehicle, after self-admin	0.8	1.7	4.6	-1.7	-1.6	-1.3	2.2	0.6	-1.3	0.8	-0.0	1.0
Time to tail flick, test, before self-admin	0.3	0.3	0.7	-0.2	0.1	-0.4	-0.6	0.8	0.6	0.5	0.8	0.4
Time to tail flick, test, after self-admin	2.0	2.1	5.5	-0.7	0.1	-1.1	-0.6	1.9	1.2	1.8	2.3	1.8
Delta time to tail flick, vehicle, before/after SA	0.3	0.3	1.1	-0.3	-0.5	0.0	1.0	-0.4	-0.6	-0.2	-0.6	0.4
Delta time to tail flick, test, before/after SA	0.2	0.2	0.4	0.3	0.5	0.2	-0.5	0.3	0.7	0.2	0.6	0.6
Tibia length	0.1	0.3	1.6	0.1	-0.3	0.2	0.0	-0.3	-0.7	-0.5	-0.5	-1.3
Ambulatory time before self-admin	0.1	0.3	2.1	-0.4	0.2	-0.6	-0.1	0.2	-0.5	0.0	0.3	-1.4
Ambulatory time after self-admin	0.8	1.3	4.1	1.0	1.7	0.3	-2.0	0.1	1.6	0.1	1.0	-0.5
Bone: tissue strength	0.1	0.1	0.4	0.0	0.6	-0.2	-0.6	0.5	0.5	0.0	0.0	-0.0
Total heroin consumption	0.7	0.9	1.9	-0.2	-0.8	0.3	1.2	-1.4	-0.8	-0.9	-1.4	0.6
Bone: trabecular number	0.4	0.7	1.3	1.1	1.0	0.9	-1.2	-0.6	0.7	-0.6	-0.4	-0.5
Bone: trabecular spacing	0.4	0.6	2.4	-0.8	-0.9	-0.5	1.0	0.1	-0.2	0.2	0.1	1.6
Bone: trabecular thickness	2.4	3.3	7.0	2.0	0.9	2.2	-0.8	-2.1	-0.5	-2.0	-2.0	-2.6
Bone: trabecular tissue density	0.1	0.1	0.4	-0.2	-0.2	-0.3	-0.1	0.3	-0.2	0.3	0.3	-0.7
Water consumed over 24 hours	1.7	3.4	9.6	-1.3	-0.2	-2.0	-0.5	2.4	1.0	2.6	3.1	1.2
Number of responses in last shaping day	0.2	0.3	0.6	0.3	0.5	0.1	-0.6	-0.1	0.8	-0.7	-0.7	0.6