Gde1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Brain	gene expression	Gde1	0.18	0.08	6.1e-13	0.11	0.12	0.12	0.13	1.2e-10	3.5e-11	1.7e-11	9.8e-12
2	pVTA	gene expression	Gde1	0.1	0.06	3.3e-04	0.08	0.07	0.07	0.07	1.9e-04	8.3e-04	6.0e-04	8.0e-04
3	Liver	gene expression	Gde1	0.32	0.12	0.0e+00	0.12	0.19	0.19	0.18	3.2e-13	1.9e-20	2.6e-20	6.6e-20
4	BLA	gene expression	Gde1	0.08	0.05	6.5e-03	0.02	0.02	0.03	0.02	2.4e-02	2.9e-02	1.2e-02	2.6e-02
5	NAcc	gene expression	Gde1	0.06	0.03	2.4e-04	0.02	0.02	0.01	0.02	2.1e-03	2.3e-03	6.3e-03	7.8e-04
6	PL	gene expression	Gde1	0.13	0.08	6.4e-07	0.04	0.05	0.04	0.04	1.9e-05	5.3e-06	3.7e-05	3.2e-05
7	Adipose	mRNA stability	Gde1	0.04	0.02	2.6e-03	0.01	0.02	0.02	0.02	3.0e-02	3.1e-03	2.4e-03	5.4e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6	7
Bone: apparent density	0.8	1.3	2.2	1.5	-1.4	-1.1	-0.9	1.0	1.0	0.7
Area under the delay curve	0.4	0.4	1.4	-0.4	0.5	0.4	1.2	-0.8	-0.2	-0.2
BMI with tail	2.4	7.6	11.5	3.4	-3.3	-2.8	-3.3	3.0	2.0	-0.2
BMI without tail	6.6	13.6	20.1	4.5	-4.4	-3.7	-4.1	4.0	3.0	-0.3
Body weight	1.8	7.6	13.0	3.5	-3.6	-3.0	-2.6	2.7	2.2	0.0
Weight adjusted by age	0.8	0.9	3.7	0.4	-0.2	-0.2	-1.9	1.3	0.5	-0.8
Bone surface	0.6	1.1	2.6	1.4	-1.5	-1.6	-0.5	0.6	0.3	-0.1
Bone volume	1.2	2.0	3.9	1.9	-2.0	-1.8	-1.0	1.0	0.8	0.8
Breakpoint value in progressive ratio session	1.2	1.3	4.2	-1.4	1.5	2.1	-0.2	0.1	0.9	0.2
Number of licking bursts	6.4	7.5	11.9	-2.8	2.7	1.8	3.4	-3.3	-3.1	-1.2
Context. condit. distance diff. score	0.3	0.4	0.8	-0.8	0.9	0.8	0.1	0.2	0.1	-0.9
Locomotion velocity, session 1	0.2	0.2	0.4	0.2	-0.1	-0.3	0.5	-0.6	-0.4	0.5
Locomotion distance, session 1	0.9	1.2	1.9	1.1	-1.0	-0.7	-1.3	1.4	1.3	0.4
Locomotion velocity, session 2	0.3	0.3	0.9	-0.3	0.2	0.1	0.9	-0.8	-0.4	0.4
Locomotion distance, session 2	1.2	1.7	3.2	1.8	-1.8	-1.7	-0.9	0.9	0.8	0.9
Locomotion velocity, session 3	0.2	0.3	0.4	0.5	-0.7	-0.6	-0.3	0.6	0.6	-0.5
Locomotion distance, session 3	0.5	0.6	1.2	0.4	-0.4	-1.1	0.6	-0.6	-1.0	-1.0
Stereotopy head waving bouts, day 3	0.3	0.4	1.3	-0.7	0.8	1.1	0.1	0.0	0.5	-0.2
Stereotopy head waving duration, day 3	0.3	0.4	1.1	-0.6	0.6	1.0	-0.2	0.4	0.8	-0.0
Locomotion velocity, session 7	0.9	1.0	3.0	0.9	-1.0	-1.7	-0.2	0.2	-0.3	-1.4
Locomotion distance, session 7	0.4	0.6	1.7	0.0	0.0	-0.8	0.7	-0.9	-1.3	-0.5
Stereotopy head waving bouts, day 7	0.4	0.4	1.2	0.4	-0.6	-0.1	-0.6	0.8	1.1	-0.3
Stereotopy head waving duration, day 7	1.5	1.8	2.6	1.3	-1.5	-1.1	-1.5	1.6	1.5	-0.5
Locomotion velocity, session 8	0.0	0.0	0.1	0.1	-0.2	-0.1	0.1	0.1	0.3	0.1
Locomotion distance, session 8	0.1	0.2	0.3	0.5	-0.4	-0.4	-0.4	0.6	0.4	-0.2
Degree of sensitization distance	0.7	0.7	2.7	-0.2	0.3	0.9	-0.6	0.4	0.8	1.6
Degree of sensitization stereotypy	1.0	1.1	2.0	1.2	-1.4	-1.2	-0.9	1.0	1.0	-0.3
Conditioned locomotion	1.1	1.2	4.4	-0.9	0.9	0.1	0.8	-0.9	-1.2	-2.1
Cocaine response after cond. corrected	0.3	0.3	0.5	-0.5	0.6	0.4	0.7	-0.7	-0.6	-0.0
Cocaine response after cond. not corrected	0.1	0.1	0.2	0.3	-0.2	-0.4	0.4	-0.2	-0.3	-0.5
Cocaine response before conditioning	1.4	1.7	4.1	1.8	-1.7	-2.0	-0.3	0.7	0.4	-1.0
Saline control response	0.2	0.2	0.4	-0.3	0.4	0.6	-0.5	0.4	0.5	0.6
Bone: connectivity density	0.4	0.6	1.0	1.0	-0.9	-0.9	-0.7	0.9	0.6	-0.4
Bone: cortical apparent density	0.7	0.9	1.2	-0.9	1.0	0.8	1.0	-1.1	-1.0	0.9
Bone: cortical area	2.2	3.3	6.9	2.5	-2.6	-2.4	-1.1	1.2	1.0	0.6
Bone: cortical porosity	1.1	1.2	2.1	0.9	-0.9	-0.6	-1.4	1.4	1.3	-0.3
Bone: cortical porosity	0.8	0.9	1.9	0.4	-0.4	-0.1	-1.4	1.4	1.3	-0.5
Bone: cortical thickness	1.0	1.7	3.6	1.8	-1.9	-1.6	-0.2	0.4	0.7	1.3
Bone: cortical thickness	0.7	0.9	3.8	0.7	-0.8	-0.4	0.7	-0.6	0.2	2.0
Bone: cortical tissue density	0.7	0.9	1.2	-0.9	1.0	0.8	0.9	-1.1	-0.9	0.9
Condit. Reinf. active minus inactive responses	0.2	0.3	0.4	-0.2	0.5	0.6	-0.6	0.4	0.6	0.4
Condit. Reinf. active-inactive response ratio	0.3	0.3	1.0	-0.1	0.3	0.3	-1.0	0.7	0.6	-0.1
Condit. Reinf. active responses	0.2	0.2	0.6	-0.3	0.4	0.6	-0.5	0.3	0.4	0.7
Condit. Reinf. inactive responses	0.1	0.1	0.7	-0.1	-0.1	0.2	-0.0	0.1	0.0	0.8
Incentive salience index mean	0.0	0.1	0.2	0.1	0.1	-0.2	-0.5	0.2	-0.1	-0.3
Condit. Reinf. lever presses	0.2	0.3	1.0	-0.3	0.3	-0.3	0.0	-0.3	-1.0	-1.0
Condit. Reinf. active minus inactive responses	1.6	2.0	4.6	0.6	-0.7	0.2	-2.1	2.1	1.9	0.6
Condit. Reinf. active-inactive response ratio	1.2	1.3	2.7	0.0	-0.0	0.9	-1.6	1.6	1.5	0.7
Condit. Reinf. active responses	0.9	1.3	3.1	0.6	-0.7	-0.1	-1.7	1.7	1.4	0.2
Condit. Reinf. inactive responses	0.6	0.7	2.0	1.0	-1.1	-1.4	-0.2	0.3	-0.1	-0.8
Condit. Reinf. lever presses	1.5	2.0	3.8	1.2	-1.4	-0.8	-1.9	1.9	1.6	0.3
Condit. Reinf. lever reinforcers received	0.8	1.1	2.7	0.2	-0.3	0.3	-1.6	1.7	1.3	0.1
Conditioned reinforcement - actives	0.5	0.5	2.1	0.4	-0.3	-0.1	0.5	0.4	1.0	1.4
Conditioned reinforcement - inactives	0.7	0.8	1.7	-0.8	0.8	0.6	1.3	-0.6	-0.4	1.2
Conditioned locomotion	0.1	0.1	0.2	-0.3	0.5	0.3	0.5	-0.2	0.0	-0.0
Patch foraging indifference point 0 sec	1.5	2.3	5.6	0.8	-0.8	0.3	-1.7	1.9	2.4	1.6
Patch foraging indifference point AUC	1.2	1.3	4.8	1.3	-1.1	-0.8	-0.8	0.4	0.5	2.2
Delay disc. indifference point, 0s delay	0.8	0.8	1.6	0.5	-0.6	-1.3	1.1	-1.1	-1.0	0.5
Delay disc. indifference point, 16s delay	3.3	3.3	7.2	-2.3	2.4	2.7	1.8	-1.3	-0.3	-0.2
Delay disc. indifference point, 2s delay	2.3	2.5	6.0	2.3	-2.4	-2.5	-0.6	0.6	0.4	0.2
Delay disc. indifference point, 24s delay	3.0	2.9	4.1	-2.0	2.0	1.9	2.0	-1.7	-1.2	-0.6
Delay disc. indifference point, 4s delay	0.4	0.4	1.5	0.3	-0.3	-0.1	1.2	-0.7	-0.1	0.8
Delay disc. indifference point, 8s delay	0.4	0.4	1.7	0.1	0.1	-0.2	1.3	-0.8	-0.5	-0.4
Indifference point function ln k	0.2	0.3	0.6	0.5	-0.5	-0.5	-0.1	0.5	0.5	-0.8
Indifference point function log k	0.2	0.3	0.6	0.5	-0.5	-0.5	-0.1	0.5	0.5	-0.8
Patch foraging total patch changes 0 sec	1.7	2.7	6.4	0.9	-0.8	0.3	-1.9	2.1	2.5	1.6
Patch foraging total patch changes 12 sec	0.4	0.6	1.3	0.7	-0.5	-0.2	-1.1	0.9	0.7	0.8
Patch foraging total patch changes 18 sec	0.4	0.5	3.0	0.1	0.0	0.4	-0.3	0.0	0.5	1.7
Patch foraging total patch changes 24 sec	1.3	1.5	2.8	1.1	-1.1	-0.2	-1.3	1.4	1.7	1.3
Patch foraging total patch changes 6 sec	1.8	2.6	9.7	-0.1	0.2	1.5	-0.9	1.0	2.1	3.1
Patch foraging time to switch 0 sec	2.8	4.4	11.2	-2.1	2.1	1.0	1.7	-1.7	-2.0	-3.3
Patch foraging water rate 0 sec	0.4	0.6	1.4	0.7	-0.8	-0.5	-0.7	0.7	0.6	1.2
Patch foraging water rate 12 sec	1.7	2.6	5.7	1.4	-1.5	-0.5	-1.5	1.9	2.4	1.6
Patch foraging water rate 18 sec	0.9	1.2	2.7	0.6	-0.7	0.1	-1.4	1.4	1.7	0.9
Patch foraging water rate 24 sec	0.5	0.7	1.3	1.0	-1.1	-0.8	-0.2	0.4	0.6	1.2
Patch foraging water rate 6 sec	0.3	0.5	3.1	0.3	-0.4	0.2	0.1	0.0	0.5	1.8
Seeking ratio, delayed vs. immediate footshock	0.1	0.1	0.4	0.0	-0.2	0.1	-0.1	0.6	0.2	-0.0
Distance traveled before self-admin	0.2	0.2	0.8	0.1	-0.3	-0.3	0.9	-0.3	-0.3	0.6
Distance traveled after self-admin	1.3	1.4	3.5	1.8	-1.6	-1.9	0.3	0.2	-0.2	0.2
Extensor digitorum longus weight	2.5	9.9	26.6	4.5	-4.5	-5.2	-1.0	0.9	0.1	-0.6
Bone: elastic displacement	0.4	0.5	1.2	-0.6	0.6	1.1	0.3	-0.1	0.4	1.1
Bone: elastic work	0.2	0.3	0.6	0.7	-0.8	-0.5	-0.2	0.4	0.5	0.5
Bone: endosteal estimation	1.1	2.4	4.7	2.0	-1.9	-2.2	-1.6	1.2	0.4	-0.3
Bone: endosteal perimeter	0.6	1.2	3.8	1.3	-1.4	-2.0	-0.4	0.2	-0.7	-0.7
Epididymis fat weight	1.1	2.5	5.0	1.4	-1.4	-0.7	-2.2	2.0	1.8	0.7
Delta time in closed arm before/after self-admin	0.8	0.8	2.5	-0.4	0.4	-0.2	0.7	-1.0	-1.1	-1.6
Delta time in open arm before/after self-admin	2.4	2.3	3.5	1.9	-1.6	-1.2	-1.5	1.4	1.3	1.6
Diff in mean of infusions in LGA sessions	1.0	1.1	2.4	-0.7	0.7	1.5	-0.8	0.8	1.0	1.4
Delay discount exponential model param	0.4	0.4	1.4	0.4	-0.5	-0.5	-1.2	0.7	0.2	0.4
Extinction: sum of active levers before priming	0.4	0.4	0.7	-0.6	0.6	0.4	0.6	-0.8	-0.8	0.0
Active lever presses in extinction session 6	0.4	0.4	0.8	0.0	0.3	0.8	-0.7	0.8	0.9	0.5
Bone: final force	3.8	6.1	12.1	3.5	-3.5	-3.2	-1.8	1.9	1.3	0.3
Bone: final moment	3.4	5.4	10.2	3.2	-3.2	-2.8	-1.9	2.0	1.5	0.5
Food consumed during 24 hour testing period	1.1	1.3	2.8	1.5	-1.7	-1.7	-0.6	0.4	0.1	0.8
Glucose	0.3	0.4	1.4	0.1	-0.2	0.5	-0.3	0.3	1.0	1.2
Heart weight	0.4	0.6	3.8	-0.1	-0.0	0.5	-0.0	0.3	0.4	1.9
Delay discount hyperbolic model param	0.2	0.2	1.1	0.1	-0.1	-0.1	-1.0	0.6	0.2	0.1
Intermittent access intake day 1-15 change	2.2	2.2	4.8	-1.0	1.1	0.2	2.2	-1.9	-2.2	0.0
Intermittent access intake escalation	1.8	1.7	4.0	-0.9	1.0	0.1	2.0	-1.7	-1.9	0.2
Intermittent access intake escalation 2	2.2	2.1	4.8	-0.9	1.0	0.2	2.2	-1.9	-2.2	0.1
Intermitt. access day 1 inactive lever presses	0.3	0.3	1.1	-0.0	0.1	0.1	1.0	-0.6	-0.5	0.8
Intermitt. access day 15 inactive lever presses	0.3	0.3	1.3	0.7	-0.5	-1.1	0.4	-0.0	-0.4	-0.2
Intermitt. access escalation Index	0.6	0.5	1.2	0.8	-1.1	-0.8	-0.8	0.7	0.2	0.3
Intermittent access day 1 total infusions	1.9	2.2	4.9	1.2	-1.0	-0.3	-2.0	2.0	2.2	0.4
Intermittent access day 15 total infusions	0.1	0.1	0.4	0.2	0.1	0.0	-0.2	0.5	0.5	0.6
Intermittent access terminal intake (last 3 days)	0.2	0.2	0.5	0.3	0.1	0.1	-0.3	0.6	0.6	0.7
Intermittent access total infusions	1.1	1.3	3.0	0.8	-0.6	-0.3	-1.3	1.6	1.7	0.7
Intermittent access day 1 locomotion	2.2	2.3	4.5	1.1	-0.8	-0.2	-2.1	2.1	2.1	0.9
Intermittent access day 15 total locomotion	1.4	1.5	3.7	-0.8	1.3	1.9	-0.2	0.4	0.9	1.9
Intermittent access total locomotion	2.1	2.3	5.0	0.7	-0.2	0.6	-2.2	2.0	2.1	1.5
Intermittent access standard deviation	0.3	0.3	1.0	0.4	-0.0	-0.6	1.0	-0.5	-0.6	0.5
Left kidney weight	2.4	6.7	12.4	3.4	-3.5	-3.1	-2.2	2.2	1.6	1.2
Right kidney weight	2.7	7.7	13.9	3.7	-3.7	-3.3	-2.3	2.4	1.8	0.8
Cocaine induced anxiety	0.1	0.1	0.3	-0.6	0.4	0.4	-0.4	-0.0	-0.5	0.3
Post-drug Anxiety	0.3	0.4	1.3	-0.6	0.4	0.8	0.1	0.0	0.5	1.1
Baseline Anxiety	0.5	0.6	0.9	0.9	-0.8	-0.5	0.5	0.3	1.0	1.0
Tail length	1.8	5.5	9.2	2.9	-3.0	-2.5	-1.9	2.3	2.3	0.6
Length with tail	0.3	1.0	2.3	1.3	-1.5	-1.3	-0.3	0.7	0.9	0.5
Length without tail	0.8	1.7	3.9	-1.3	1.2	0.8	2.0	-1.7	-1.3	-0.1
Times rat made contact with spout	1.5	1.7	4.3	1.2	-1.3	-2.1	0.8	-0.7	-1.2	-1.3
Lifetime Intake	1.9	2.1	4.4	1.3	-1.0	-0.6	-1.7	2.0	2.1	0.7
Liver weight, left	0.3	0.5	1.2	0.3	-0.5	-0.3	-1.1	1.1	0.8	-0.3
Liver weight, right	0.6	1.0	2.6	0.5	-0.7	-0.8	-1.4	1.1	0.1	-1.6
Locomotor activity	0.1	0.2	0.5	0.1	-0.1	0.1	-0.7	0.5	0.5	-0.4
Locomotor testing distance	0.4	0.7	1.3	0.7	-0.7	-0.2	-1.2	1.0	1.1	0.4
Locomotor testing rearing	0.4	0.6	1.5	0.0	-0.0	0.5	-1.2	1.1	1.1	-0.6
Locomotion in novel chamber	1.5	1.8	4.4	0.9	-0.9	-0.2	-2.0	2.1	1.6	0.3
Locomotion in novel chamber post-restriction	1.1	1.3	2.3	-0.3	0.7	1.2	-1.2	1.3	1.2	1.5
Fecal boli incidents, locomotor time 1	0.8	0.9	4.0	-0.9	0.6	0.7	-0.4	0.5	-0.2	-2.0
Change in fecal boli incidents, locomotor task	2.5	2.3	8.1	1.0	-0.8	0.3	-0.7	1.3	2.1	2.8
Time >=10cm from walls, locomotor time 1	0.4	0.4	1.0	0.7	-1.0	-1.0	-0.1	0.4	-0.0	0.1
Bouts of movement, locomotor time 1	1.9	2.1	4.0	-2.0	2.0	2.0	0.7	-0.7	-1.0	-0.6
Total resting periods, locomotor time 1	2.3	2.6	4.7	-2.2	2.2	2.1	1.0	-0.9	-1.1	-1.0
Rest time, locomotor task time 1	1.7	1.9	4.4	-0.7	1.1	0.5	2.1	-1.5	-1.5	-1.5
Distance moved, locomotor task time 1	2.2	2.4	4.0	1.4	-1.4	-0.8	-2.0	1.4	1.7	1.9
Vertical activity count, locomotor time 1	2.5	2.6	5.5	1.9	-1.9	-1.7	-1.2	0.7	0.9	2.3
Time >=10cm from walls, locomotor time 2	1.3	1.4	3.8	1.6	-1.7	-2.0	-0.5	0.5	0.2	0.3
Bouts of movement, locomotor time 2	1.0	1.1	5.6	-0.2	0.2	-0.6	-1.0	0.8	-0.4	-2.4
Total resting periods, locomotor time 2	1.0	1.1	5.0	0.1	-0.1	-0.8	-1.1	0.9	-0.3	-2.2
Rest time, locomotor task time 2	0.1	0.1	0.3	0.2	-0.2	0.2	0.1	0.4	0.5	-0.1
Distance moved, locomotor task time 2	0.6	0.7	1.5	0.5	-0.6	-1.2	0.4	-1.0	-1.0	1.0
Vertical activity count, locomotor time 2	0.9	1.0	3.6	0.8	-1.0	-1.0	0.4	-0.6	-0.5	1.9
Light reinforcement 1	0.4	0.8	1.5	-0.4	0.3	1.0	-1.0	1.1	1.2	-0.4
Light reinforcement 2	0.6	0.8	1.9	-0.0	-0.0	0.6	-1.3	1.4	1.3	0.1
Bone: marrow area	1.0	2.1	4.2	1.9	-1.8	-2.0	-1.5	1.1	0.3	-0.3
Bone: maximum diameter	1.4	2.6	5.0	2.0	-2.2	-2.1	-1.4	1.3	0.7	0.3
Bone: maximum force	2.9	5.1	10.5	3.2	-3.2	-3.0	-1.5	1.5	1.1	0.4
Bone: maximum moment	2.5	4.3	8.6	2.9	-2.9	-2.6	-1.6	1.6	1.3	0.5
Mean time between licks in bursts	0.2	0.3	0.8	-0.5	0.4	0.0	0.3	-0.2	-0.9	-0.9
Mean num. licks in bursts	5.6	6.7	11.0	3.3	-3.3	-2.8	-2.5	2.5	2.1	0.6
Cd content in liver	2.9	3.2	9.3	-2.4	2.5	3.1	0.4	-0.1	0.7	0.1
Co content in liver	0.7	0.8	2.8	-0.5	0.4	1.2	0.2	0.1	0.8	1.7
Cu content in liver	0.7	0.9	1.7	0.8	-0.7	0.0	-0.7	1.0	1.3	1.3
Fe content in liver	0.7	0.9	1.8	-0.9	0.9	1.0	1.4	-1.2	-0.6	0.2
K content in liver	0.2	0.2	0.7	0.2	-0.1	-0.0	-0.8	0.6	0.2	0.5
Mg content in liver	0.5	0.5	1.3	-0.4	0.5	0.5	-1.2	1.0	0.3	-0.7
Mn content in liver	0.3	0.4	1.2	0.4	-0.4	-0.8	0.2	-0.2	-0.6	-1.1
Na content in liver	2.9	3.1	8.6	2.2	-2.2	-2.9	-0.8	0.5	-0.6	-1.3
Rb content in liver	1.5	1.9	3.7	-0.8	0.8	1.9	-1.0	1.3	1.9	1.4
Se content in liver	0.2	0.2	0.7	0.4	-0.3	-0.6	0.3	-0.5	-0.9	-0.1
Sr content in liver	0.5	0.4	0.8	0.9	-0.8	-0.8	-0.7	0.5	0.2	0.1
Zn content in liver	2.2	2.5	3.9	2.0	-1.9	-1.8	-1.7	1.7	0.9	-0.6
Bone: minimum diameter	1.2	2.2	4.9	1.9	-2.1	-2.2	-1.1	1.0	0.4	-0.4
Time in familiar zone, hab. session 1	0.7	0.7	3.1	-0.5	0.5	1.0	0.4	-0.4	0.1	1.8
Time in novel zone, hab. session 1	1.2	1.2	5.8	0.5	-0.6	-1.0	-0.4	0.7	0.4	-2.4
Total zone transitions, hab. session 1	2.3	3.2	5.1	2.3	-2.2	-1.6	-1.5	1.4	1.7	1.7
Total locomotion distance, hab. session 1	5.2	7.3	10.9	3.3	-3.3	-2.2	-2.5	2.7	2.8	1.8
Locomotion velocity, hab. session 1	4.6	6.6	8.9	3.0	-2.9	-1.9	-2.7	2.7	2.7	1.9
Time in familiar zone, hab. session 2	0.4	0.4	1.2	0.7	-0.8	-0.6	-0.5	0.4	0.3	1.1
Time in novel zone, hab. session 2	0.2	0.2	0.7	-0.2	0.3	0.4	-0.1	0.2	0.4	-0.9
Total zone transitions, hab. session 2	2.3	3.0	3.9	2.0	-2.0	-1.3	-1.7	1.7	1.9	1.5
Total locomotion distance, hab. session 2	2.8	3.7	6.1	2.5	-2.4	-1.7	-1.5	1.7	1.9	1.6
Locomotion velocity, hab. session 2	3.2	4.3	7.1	2.7	-2.6	-2.0	-1.7	1.8	1.9	1.6
Novel to familiar place preference ratio	0.7	0.7	1.0	-0.8	0.9	0.8	1.0	-0.9	-0.8	0.7
Novelty place preference	1.0	1.0	1.7	-0.8	0.9	0.8	1.3	-1.2	-1.0	0.7
Time in novel zone, NPP test	0.7	0.7	0.9	-0.8	0.8	0.9	1.0	-0.9	-0.6	0.8
Total zone transitions, NPP test	1.3	1.9	3.0	1.7	-1.7	-1.3	-1.2	1.3	1.3	0.9
Total locomotion distance, NPP test	1.5	2.0	3.6	1.9	-1.9	-1.4	-0.8	1.0	1.0	1.5
Locomotion velocity, NPP test	1.1	1.6	3.0	1.7	-1.7	-1.3	-0.7	0.8	0.9	1.4
Intraocular pressure	0.2	0.3	0.4	0.6	-0.5	-0.5	-0.5	0.7	0.5	-0.3
Delta distance traveled before/after self-admin	1.0	1.1	2.2	1.5	-1.2	-1.4	-0.8	0.8	0.5	-0.8
Delta ambulatory time before/after self-admin	0.8	0.8	2.1	1.4	-1.1	-1.3	-0.6	0.4	0.3	-0.4
Parametrial fat weight	2.5	4.9	6.6	2.3	-2.6	-1.6	-2.4	2.4	2.3	1.5
Pavlov. Cond. lever latency	1.2	1.5	6.2	-0.6	0.5	1.3	1.1	-0.9	0.5	2.5
Pavlov. Cond. magazine entry latency	2.4	3.1	5.7	1.6	-1.4	-1.9	-2.1	1.8	0.3	-2.4
Pavlov. Cond. change in total contacts	1.9	2.0	8.4	0.6	-0.5	-1.7	-0.2	-0.0	-1.5	-2.9
Pavlov. Cond. index score	1.8	2.2	8.2	0.8	-0.7	-1.5	-1.5	1.2	-0.4	-2.9
Pavlov. Cond. latency score	1.6	2.0	6.9	0.8	-0.7	-1.4	-1.5	1.3	-0.3	-2.6
Pavlov. Cond. lever contacts	1.8	2.1	7.3	0.9	-0.8	-1.7	-1.3	1.0	-0.6	-2.7
Pavlov. Cond. magazine entry number	1.6	1.9	7.1	-0.9	0.7	1.7	1.1	-0.8	0.7	2.7
Pavlov. Cond. intertrial magazine entries	1.2	1.4	4.7	-1.0	0.8	1.7	0.2	-0.1	0.7	2.2
Pavlov. Cond. lever-magazine prob. diff.	2.1	2.7	8.6	1.0	-1.0	-1.7	-1.7	1.4	-0.3	-2.9
Pavlov. Cond. response bias	2.0	2.5	10.4	0.8	-0.7	-1.8	-0.9	0.6	-1.0	-3.2
Pavlov. Cond. lever latency	1.0	1.3	2.1	-1.1	1.1	0.8	1.5	-1.4	-1.1	-0.8
Pavlov. Cond. magazine entry latency	1.6	1.9	2.8	-1.4	1.6	0.7	1.3	-1.3	-1.7	-1.4
Pavlov. Cond. change in total contacts	1.1	1.5	3.1	-0.1	0.2	1.0	-1.4	1.3	1.6	1.8
Pavlov. Cond. index score	0.1	0.1	0.2	-0.3	0.4	0.3	-0.4	0.3	0.0	0.1
Pavlov. Cond. latency score	0.0	0.0	0.1	-0.2	0.2	0.1	-0.2	0.2	-0.1	-0.1
Pavlov. Cond. lever contacts	1.1	1.5	2.8	1.1	-1.1	-0.9	-1.7	1.7	1.3	0.3
Pavlov. Cond. magazine entry number	1.4	1.7	3.5	1.8	-1.9	-1.6	-0.9	1.0	0.9	0.3
Pavlov. Cond. intertrial magazine entries	2.4	3.1	4.3	2.0	-2.0	-1.7	-2.0	2.1	1.5	0.1
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.1	0.4	-0.5	0.6	0.4	-0.2	0.1	-0.2	-0.1
Pavlov. Cond. response bias	0.2	0.3	0.9	0.1	-0.0	0.0	-0.9	0.9	0.5	0.1
Time in closed arm before self-admin	0.7	0.8	1.3	0.9	-0.9	-0.7	-0.9	1.1	0.9	0.9
Time in closed arm after self-admin	0.5	0.6	1.7	-0.7	0.8	1.3	0.4	-0.1	0.5	0.8
Time in open arm before self-admin	1.7	1.9	2.9	-1.7	1.7	1.3	1.1	-1.4	-1.2	-0.8
Time in open arm after self-admin	0.9	1.0	3.0	1.5	-1.2	-1.7	-0.3	-0.1	-0.6	0.2
Bone: periosteal estimation	2.0	4.2	8.3	2.7	-2.8	-2.9	-1.7	1.5	0.8	0.2
Bone: periosteal perimeter	1.1	1.8	3.1	1.6	-1.8	-1.8	-1.3	1.2	0.6	-0.2
Bone: post-yield work	2.9	4.0	8.0	1.9	-1.8	-1.2	-2.8	2.6	2.2	0.3
Progressive ratio test 1 active lever presses	1.0	1.1	2.8	0.7	-0.4	-0.0	-1.7	1.5	1.3	0.3
Progressive ratio test 1 breakpoint	1.0	1.0	2.6	0.6	-0.4	0.0	-1.6	1.5	1.3	0.2
Progressive ratio test 1 inactive lever presses	0.5	0.6	1.3	0.5	-0.6	-0.4	-1.1	1.1	0.6	0.4
Progressive ratio test 2 active lever presses	0.9	0.9	2.4	0.5	-0.2	0.2	-1.3	1.4	1.5	0.2
Progressive ratio test 2 breakpoint	0.9	1.0	2.5	0.5	-0.2	0.3	-1.4	1.5	1.6	0.2
Progressive ratio test 2 inactive lever presses	0.6	0.6	1.4	0.2	0.1	0.5	-1.1	1.1	1.2	0.5
Incentive Sensitization - Responses	0.3	0.4	0.7	0.0	0.1	0.3	-0.8	0.8	0.7	-0.8
Incentive Sensitization - Breakpoint	0.4	0.4	0.8	0.1	0.1	0.3	-0.9	0.8	0.9	-0.6
Sum of active levers in priming session hrs 5-6	0.4	0.3	1.0	-0.1	0.4	0.5	-1.0	0.7	0.7	-0.3
Progressive ratio	0.6	0.7	1.7	-0.2	0.3	0.8	-0.6	0.6	1.3	1.2
Food seeking constrained by brief footshock	1.1	1.3	2.0	-1.4	1.1	1.3	1.2	-1.4	-0.8	0.7
Seeking ratio, punishment vs. effort	0.3	0.4	1.0	0.0	-0.3	-0.6	0.3	-0.4	-1.0	-1.0
Retroperitoneal fat weight	1.1	3.8	8.2	0.8	-0.7	0.6	-2.7	2.7	2.9	1.4
Reaction time number correct	0.6	0.8	1.7	-1.3	1.1	1.2	0.3	-0.3	-0.0	-1.0
Reaction time mean minus median	0.2	0.2	1.3	0.3	-0.3	-0.3	-0.4	0.2	-0.1	1.1
Reaction time mean minus median AUC	0.3	0.4	1.1	-0.3	0.3	0.7	-0.7	0.6	0.6	1.0
Reaction time num false alarms	1.4	1.9	4.4	-0.9	1.0	0.4	1.7	-2.1	-2.0	0.6
Reaction time num false alarms AUC	0.9	1.3	2.8	-0.8	1.0	0.3	1.3	-1.7	-1.7	0.2
Reaction time trials correct on left	0.6	0.8	1.7	-1.3	1.1	1.2	0.3	-0.3	-0.0	-1.0
Reaction time trials on left	0.6	0.8	1.7	-1.3	1.1	1.2	0.3	-0.2	0.0	-1.0
Reaction time mean	0.6	0.8	1.6	0.7	-0.5	-0.4	-1.2	1.1	0.7	1.2
Reaction time mean AUC	0.3	0.4	1.2	0.4	-0.2	-0.1	-1.1	1.0	0.5	0.6
Median of all reaction times	0.6	0.8	1.8	0.7	-0.5	-0.4	-1.3	1.2	0.8	0.8
Reaction time omissions	0.4	0.5	1.4	-0.8	0.9	0.6	-0.4	0.2	-0.3	-1.2
Reaction time false alarm rate	0.8	1.1	3.0	-0.1	0.2	-0.4	1.3	-1.6	-1.7	0.4
Reaction time premature initiation rate	1.0	1.3	3.6	1.7	-1.3	-1.9	0.2	-0.2	-0.3	-0.9
Reaction time premature initiations	0.6	0.8	2.9	0.7	-0.5	-1.1	0.6	-0.5	-0.5	-1.7
Std. dev. reaction times	0.4	0.6	1.3	0.5	-0.5	-0.2	-0.9	0.9	0.7	1.1
Reaction time trials completed	0.6	0.8	1.7	-1.3	1.1	1.2	0.3	-0.2	0.0	-1.0
Reaction time trials AUC	0.4	0.6	1.2	-1.1	1.0	1.0	0.2	-0.1	0.1	-0.9
Run reversals in cocaine runway, females	3.6	3.5	8.4	2.7	-2.8	-2.9	-0.4	0.7	0.4	0.2
Run reversals in cocaine runway, males	0.5	0.5	1.3	-0.9	0.6	0.4	1.1	-0.7	-0.7	-0.3
Latency to leave start box in cocaine runway	0.6	0.6	1.8	-0.3	0.4	1.0	-0.4	0.6	1.3	0.8
Latency to leave start box in cocaine runway, F	0.3	0.3	0.6	-0.6	0.6	0.8	-0.3	0.4	0.4	-0.6
Latency to leave start box in cocaine runway, M	0.7	0.7	2.0	-0.1	0.1	0.9	-0.0	0.0	1.4	1.4
Std. dev. time between licks in bursts	0.2	0.2	1.0	0.1	-0.0	-0.2	-1.0	0.7	-0.2	-0.0
Total sessions with >9 infusions	3.0	3.3	5.0	2.2	-2.2	-2.2	-1.2	1.9	1.7	0.3
Short access day 1 total inactive lever presses	0.2	0.2	0.8	-0.0	-0.0	0.2	-0.1	0.5	0.9	0.6
Short access day 10 total inactive lever presses	0.9	1.0	2.7	-0.8	0.8	0.7	1.6	-1.2	-0.9	0.7
Short access day 1 total infusions	1.6	1.7	4.2	1.2	-1.1	-0.7	-1.0	1.7	2.0	0.9
Short access day 10 total infusions	1.2	1.3	1.9	1.4	-1.1	-1.2	-1.1	1.4	1.2	0.1
Short access total infusions	2.9	3.3	6.5	1.8	-1.5	-1.0	-1.9	2.4	2.6	0.8
Short access day 1 locomotion	0.3	0.3	1.0	0.5	-0.3	-0.2	0.1	0.5	1.0	0.6
Short access day 10 total locomotion	2.2	2.4	5.8	1.6	-1.4	-1.0	-2.4	1.9	1.4	0.5
Short access total locomotion	3.9	4.0	8.9	1.6	-1.3	-0.3	-2.4	2.6	3.0	1.5
One hour access (0.3 mA shock)	2.5	3.0	6.8	1.4	-1.4	-0.8	-2.6	2.3	1.9	0.7
Compulsive drug intake	1.0	1.0	3.7	0.3	-0.7	0.2	-1.9	1.1	1.1	-0.1
One hour access (shock baseline)	0.2	0.2	0.8	-0.2	0.5	0.4	0.2	0.2	0.2	0.9
Social response proportion	0.8	0.9	1.4	-0.6	0.5	1.0	-1.1	1.0	1.0	1.2
Social responses	0.5	0.6	1.5	-1.2	1.0	1.2	-0.6	0.3	-0.0	0.4
Social time	0.8	1.1	2.6	-1.4	1.4	1.6	0.4	-0.6	0.0	0.7
Soleus weight	1.5	4.3	8.7	2.9	-2.8	-2.4	-1.0	1.2	1.5	1.8
Bone: stiffness	2.2	3.4	7.7	2.7	-2.8	-2.7	-0.8	0.7	0.4	0.6
Tibialis anterior weight	4.3	14.7	29.5	5.4	-5.4	-5.1	-2.4	2.5	2.2	1.0
Time to tail flick, vehicle, before self-admin	0.2	0.2	0.5	0.2	-0.6	-0.7	0.0	-0.2	-0.5	0.1
Time to tail flick, vehicle, after self-admin	1.2	1.3	3.1	-1.8	1.4	1.2	0.3	-0.4	-0.6	-1.3
Time to tail flick, test, before self-admin	0.6	0.6	1.6	0.0	-0.2	-0.7	0.8	-1.0	-1.3	-0.0
Time to tail flick, test, after self-admin	2.2	2.3	6.1	-1.2	1.2	0.1	1.2	-1.7	-2.5	-1.6
Delta time to tail flick, vehicle, before/after SA	0.4	0.4	0.6	-0.6	0.7	0.7	-0.6	0.5	0.5	-0.8
Delta time to tail flick, test, before/after SA	0.2	0.2	0.9	-0.3	0.4	0.2	-0.1	0.0	-0.5	-0.9
Tibia length	0.1	0.3	1.3	-0.1	0.1	0.4	0.2	0.1	0.4	1.2
Ambulatory time before self-admin	0.3	0.3	1.0	-0.1	-0.1	0.0	1.0	-0.2	-0.2	1.0
Ambulatory time after self-admin	1.3	1.4	3.7	1.7	-1.6	-1.9	0.5	0.1	-0.2	0.3
Bone: tissue strength	0.1	0.1	0.3	0.1	-0.1	-0.3	0.6	-0.4	-0.5	-0.4
Total heroin consumption	1.0	1.2	2.2	-1.1	1.0	1.5	-1.0	1.1	1.2	-0.3
Bone: trabecular number	0.4	0.6	1.3	1.1	-1.1	-0.9	-0.3	0.5	0.6	0.4
Bone: trabecular spacing	0.5	0.6	1.4	-1.2	1.2	0.8	-0.1	-0.1	-0.7	-0.8
Bone: trabecular thickness	4.0	4.8	9.9	2.0	-2.0	-0.7	-2.1	2.0	2.7	3.2
Bone: trabecular tissue density	0.2	0.2	1.3	0.1	-0.1	-0.1	0.0	-0.3	-0.2	1.1
Water consumed over 24 hours	3.0	3.6	7.6	-1.0	0.9	-0.3	2.6	-2.5	-2.8	-1.6
Number of responses in last shaping day	0.5	0.5	1.0	0.8	-1.0	-0.7	-0.5	0.7	0.8	-0.1