Hub : Genes

Tmem179b

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Brain	intron excision ratio	chr1_215100175_215100254	0.02	0.02	8.6e-03	0.02	0.01	0	0.01	3.8e-03	1.3e-02	3.0e-01	1.9e-02
2	Adipose	gene expression	Tmem179b	0.06	0.04	3.3e-03	0.03	0.02	0.02	0.02	4.1e-04	4.1e-03	2.3e-03	8.8e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Bone: apparent density	0.9	1.5	2.1	0.9	-1.4
Area under the delay curve	0.4	0.4	0.9	0.1	-0.9
BMI with tail	4.2	14.4	21.5	2.7	-4.6
BMI without tail	1.0	3.1	5.2	1.0	-2.3
Body weight	3.1	13.7	13.8	3.7	-3.7
Weight adjusted by age	0.6	0.9	1.3	1.2	-0.6
Bone surface	2.4	4.3	5.0	2.2	-1.9
Bone volume	1.4	2.5	2.8	1.5	-1.7
Breakpoint value in progressive ratio session	1.3	1.5	2.9	1.7	0.5
Number of licking bursts	0.0	0.0	0.0	-0.1	-0.2
Context. condit. distance diff. score	0.5	0.6	0.9	-0.6	-0.9
Locomotion velocity, session 1	0.2	0.2	0.3	-0.2	-0.6
Locomotion distance, session 1	1.0	1.2	2.1	0.6	-1.4
Locomotion velocity, session 2	1.6	1.9	2.6	1.6	-1.1
Locomotion distance, session 2	0.1	0.1	0.2	0.3	-0.4
Locomotion velocity, session 3	2.3	2.6	4.9	0.5	-2.2
Locomotion distance, session 3	0.2	0.2	0.4	0.2	-0.6
Stereotopy head waving bouts, day 3	1.6	1.9	3.5	-0.5	-1.9
Stereotopy head waving duration, day 3	0.8	1.0	1.7	-0.5	-1.3
Locomotion velocity, session 7	0.4	0.4	0.8	-0.0	-0.9
Locomotion distance, session 7	0.5	0.6	1.1	-0.2	-1.0
Stereotopy head waving bouts, day 7	0.2	0.3	0.4	0.3	-0.6
Stereotopy head waving duration, day 7	1.0	1.2	1.7	1.3	-0.8
Locomotion velocity, session 8	0.0	0.1	0.1	-0.3	0.2
Locomotion distance, session 8	0.7	1.1	1.6	-0.8	-1.3
Degree of sensitization distance	1.1	1.2	2.3	-0.1	-1.5
Degree of sensitization stereotypy	0.5	0.5	0.9	1.0	-0.4
Conditioned locomotion	0.4	0.4	0.6	0.8	-0.5
Cocaine response after cond. corrected	0.3	0.4	0.7	-0.9	-0.3
Cocaine response after cond. not corrected	0.2	0.2	0.4	-0.6	-0.2
Cocaine response before conditioning	0.3	0.4	0.6	0.8	0.5
Saline control response	1.4	1.9	3.5	1.9	-0.5
Bone: connectivity density	2.2	3.4	3.5	1.8	-1.9
Bone: cortical apparent density	0.4	0.6	0.8	0.6	0.9
Bone: cortical area	0.7	1.1	1.5	1.2	-0.8
Bone: cortical porosity	0.8	0.8	1.6	-0.2	1.3
Bone: cortical porosity	0.5	0.5	1.0	0.1	1.0
Bone: cortical thickness	1.8	3.0	5.7	2.4	0.6
Bone: cortical thickness	0.3	0.4	0.5	0.7	0.4
Bone: cortical tissue density	0.6	0.8	0.9	0.8	0.9
Condit. Reinf. active minus inactive responses	0.7	0.8	1.3	1.1	-0.5
Condit. Reinf. active-inactive response ratio	0.3	0.3	0.5	0.7	0.2
Condit. Reinf. active responses	0.8	1.0	1.1	1.1	-0.9
Condit. Reinf. inactive responses	0.4	0.4	0.9	-0.1	-0.9
Incentive salience index mean	1.3	1.6	1.7	1.3	-1.2
Condit. Reinf. lever presses	1.3	1.9	2.3	1.2	-1.5
Condit. Reinf. active minus inactive responses	0.1	0.2	0.2	-0.3	0.5
Condit. Reinf. active-inactive response ratio	0.2	0.3	0.5	-0.7	-0.3
Condit. Reinf. active responses	0.1	0.1	0.1	0.3	0.3
Condit. Reinf. inactive responses	0.2	0.2	0.2	0.5	0.4
Condit. Reinf. lever presses	0.7	1.0	1.4	1.2	-0.7
Condit. Reinf. lever reinforcers received	0.2	0.2	0.3	0.5	0.4
Conditioned reinforcement - actives	0.1	0.2	0.2	-0.4	0.4
Conditioned reinforcement - inactives	0.2	0.3	0.6	-0.2	-0.8
Conditioned locomotion	1.2	1.6	3.0	-1.7	-0.5
Patch foraging indifference point 0 sec	0.3	0.6	0.7	0.9	-0.7
Patch foraging indifference point AUC	0.9	1.2	2.2	1.5	0.5
Delay disc. indifference point, 0s delay	0.8	0.9	1.3	-0.7	-1.1
Delay disc. indifference point, 16s delay	0.3	0.4	0.6	0.3	-0.8
Delay disc. indifference point, 2s delay	0.5	0.5	0.8	-0.5	-0.9
Delay disc. indifference point, 24s delay	0.1	0.1	0.2	0.3	-0.4
Delay disc. indifference point, 4s delay	0.7	0.7	1.3	0.4	-1.1
Delay disc. indifference point, 8s delay	0.2	0.2	0.5	-0.7	-0.0
Indifference point function ln k	1.6	2.8	5.2	-2.3	-0.6
Indifference point function log k	1.6	2.8	5.2	-2.3	-0.6
Patch foraging total patch changes 0 sec	0.2	0.4	0.7	0.8	-0.4
Patch foraging total patch changes 12 sec	3.4	4.4	8.7	3.0	-0.2
Patch foraging total patch changes 18 sec	0.4	0.7	1.1	1.1	0.4
Patch foraging total patch changes 24 sec	3.3	5.7	9.4	3.1	-1.4
Patch foraging total patch changes 6 sec	0.9	1.3	1.9	1.4	-0.9
Patch foraging time to switch 0 sec	0.5	1.0	1.4	0.7	-1.2
Patch foraging water rate 0 sec	0.3	0.7	0.8	-0.9	0.8
Patch foraging water rate 12 sec	0.9	1.9	3.4	-1.9	0.6
Patch foraging water rate 18 sec	0.4	0.6	0.7	-0.8	-0.6
Patch foraging water rate 24 sec	0.7	1.0	1.6	-1.3	0.7
Patch foraging water rate 6 sec	0.9	1.4	2.3	-1.5	0.7
Seeking ratio, delayed vs. immediate footshock	0.1	0.1	0.1	0.3	-0.4
Distance traveled before self-admin	1.6	2.1	3.3	1.8	-0.9
Distance traveled after self-admin	0.4	0.5	0.8	0.9	0.4
Extensor digitorum longus weight	4.4	17.5	27.0	5.2	-2.8
Bone: elastic displacement	0.7	0.8	1.1	-0.7	1.1
Bone: elastic work	0.4	0.5	1.1	1.0	-0.1
Bone: endosteal estimation	1.7	3.7	5.5	-1.4	-2.3
Bone: endosteal perimeter	1.7	3.6	4.2	-1.7	-2.0
Epididymis fat weight	0.6	2.1	2.2	-1.4	-1.5
Delta time in closed arm before/after self-admin	0.8	0.8	0.8	0.8	-0.9
Delta time in open arm before/after self-admin	1.3	1.3	2.4	1.6	-0.4
Diff in mean of infusions in LGA sessions	1.5	1.8	3.6	1.9	-0.0
Delay discount exponential model param	0.4	0.4	0.8	-0.1	0.9
Extinction: sum of active levers before priming	2.9	3.1	5.2	2.3	-1.0
Active lever presses in extinction session 6	2.0	1.9	3.8	2.0	-0.2
Bone: final force	1.5	2.4	2.7	1.6	-1.5
Bone: final moment	1.5	2.4	2.8	1.7	-1.5
Food consumed during 24 hour testing period	0.1	0.1	0.2	-0.4	0.4
Glucose	1.7	2.6	4.1	-2.0	-1.0
Heart weight	1.2	1.9	3.6	-0.5	-1.9
Delay discount hyperbolic model param	0.4	0.4	0.8	-0.0	0.9
Intermittent access intake day 1-15 change	0.7	1.5	1.8	-1.3	1.1
Intermittent access intake escalation	0.9	1.9	2.2	-1.5	1.3
Intermittent access intake escalation 2	0.4	0.5	0.5	-0.7	0.7
Intermitt. access day 1 inactive lever presses	0.4	1.4	1.6	-1.3	1.1
Intermitt. access day 15 inactive lever presses	0.6	1.3	2.1	0.8	-1.4
Intermitt. access escalation Index	0.3	0.5	0.7	-0.9	0.5
Intermittent access day 1 total infusions	2.2	3.6	6.6	-0.7	-2.6
Intermittent access day 15 total infusions	1.6	2.4	4.4	-2.1	-0.6
Intermittent access terminal intake (last 3 days)	1.4	1.9	2.7	-1.0	-1.6
Intermittent access total infusions	1.9	2.2	3.2	-1.1	-1.8
Intermittent access day 1 locomotion	1.7	2.2	4.3	-0.2	-2.1
Intermittent access day 15 total locomotion	0.6	1.2	2.2	-0.4	-1.5
Intermittent access total locomotion	2.9	3.5	6.8	-0.4	-2.6
Intermittent access standard deviation	0.3	0.7	1.3	-1.1	0.4
Left kidney weight	0.3	1.5	2.6	-0.6	-1.6
Right kidney weight	0.1	0.6	1.2	-0.4	-1.1
Cocaine induced anxiety	0.1	0.1	0.2	0.1	0.5
Post-drug Anxiety	0.2	0.2	0.3	0.6	0.0
Baseline Anxiety	0.3	0.3	0.4	0.6	-0.5
Tail length	0.2	0.6	0.9	0.9	0.6
Length with tail	0.7	3.0	5.9	2.4	-0.4
Length without tail	1.8	5.8	10.4	3.2	-1.1
Times rat made contact with spout	0.1	0.1	0.2	0.2	0.5
Lifetime Intake	1.6	1.9	2.8	-1.0	-1.7
Liver weight, left	0.8	1.4	2.1	-1.4	0.8
Liver weight, right	0.9	1.5	2.7	-1.7	-0.5
Locomotor activity	0.6	1.0	1.6	-1.3	0.6
Locomotor testing distance	0.5	0.9	1.7	-1.3	0.2
Locomotor testing rearing	0.5	1.0	1.9	-1.4	0.4
Locomotion in novel chamber	1.0	1.3	2.6	-1.6	-0.2
Locomotion in novel chamber post-restriction	1.1	1.8	3.1	-1.8	0.7
Fecal boli incidents, locomotor time 1	0.1	0.1	0.2	-0.3	0.4
Change in fecal boli incidents, locomotor task	0.7	0.7	1.4	-1.2	-0.2
Time >=10cm from walls, locomotor time 1	0.8	0.9	1.7	-1.3	-0.3
Bouts of movement, locomotor time 1	2.1	2.4	4.5	0.5	2.1
Total resting periods, locomotor time 1	1.5	1.7	3.1	0.5	1.8
Rest time, locomotor task time 1	1.5	1.8	2.3	-1.5	1.2
Distance moved, locomotor task time 1	0.5	0.7	0.9	0.7	-0.9
Vertical activity count, locomotor time 1	0.1	0.2	0.4	-0.6	-0.1
Time >=10cm from walls, locomotor time 2	0.2	0.2	0.5	-0.1	0.7
Bouts of movement, locomotor time 2	0.5	0.7	1.5	1.2	0.0
Total resting periods, locomotor time 2	0.2	0.3	0.7	0.8	0.0
Rest time, locomotor task time 2	1.8	2.3	4.0	-2.0	0.7
Distance moved, locomotor task time 2	0.4	0.5	0.7	0.8	0.6
Vertical activity count, locomotor time 2	0.4	0.5	1.0	-0.1	1.0
Light reinforcement 1	0.1	0.3	0.7	-0.1	0.8
Light reinforcement 2	0.0	0.1	0.1	-0.1	-0.3
Bone: marrow area	1.7	3.8	5.2	-1.5	-2.3
Bone: maximum diameter	0.4	0.7	1.2	0.5	-1.1
Bone: maximum force	3.1	5.6	6.4	2.2	-2.5
Bone: maximum moment	3.0	5.3	6.0	2.2	-2.4
Mean time between licks in bursts	0.1	0.3	0.4	0.5	-0.6
Mean num. licks in bursts	0.2	0.3	0.5	-0.1	0.7
Cd content in liver	0.3	0.4	0.7	-0.9	0.2
Co content in liver	1.6	1.9	3.0	-0.9	1.7
Cu content in liver	0.1	0.1	0.3	-0.1	0.5
Fe content in liver	0.0	0.0	0.0	-0.2	-0.2
K content in liver	0.6	0.6	0.9	0.5	-1.0
Mg content in liver	0.6	0.6	1.2	-0.1	-1.1
Mn content in liver	2.0	2.2	3.9	2.0	-0.7
Na content in liver	0.4	0.4	0.4	0.7	-0.6
Rb content in liver	1.8	2.1	4.0	-2.0	0.4
Se content in liver	0.1	0.2	0.3	0.3	-0.5
Sr content in liver	2.4	2.1	4.2	2.0	-0.1
Zn content in liver	1.7	1.9	3.0	1.7	-0.8
Bone: minimum diameter	1.5	2.7	4.6	-0.9	-2.1
Time in familiar zone, hab. session 1	0.3	0.3	0.5	0.3	-0.7
Time in novel zone, hab. session 1	1.1	1.1	1.5	-1.2	0.8
Total zone transitions, hab. session 1	0.1	0.1	0.1	0.4	0.1
Total locomotion distance, hab. session 1	0.2	0.3	0.5	-0.3	-0.7
Locomotion velocity, hab. session 1	0.1	0.2	0.3	0.2	-0.5
Time in familiar zone, hab. session 2	0.5	0.6	1.0	-0.4	1.0
Time in novel zone, hab. session 2	1.0	1.0	1.7	0.6	-1.3
Total zone transitions, hab. session 2	1.4	1.7	2.0	1.2	-1.4
Total locomotion distance, hab. session 2	0.6	0.8	1.5	0.2	-1.2
Locomotion velocity, hab. session 2	0.6	0.8	1.5	0.0	-1.2
Novel to familiar place preference ratio	1.2	1.3	2.2	1.5	-0.7
Novelty place preference	0.7	0.8	1.3	1.1	-0.5
Time in novel zone, NPP test	0.9	0.9	1.4	1.2	-0.7
Total zone transitions, NPP test	0.6	0.9	1.2	1.1	-0.8
Total locomotion distance, NPP test	0.2	0.3	0.6	0.0	-0.8
Locomotion velocity, NPP test	0.1	0.1	0.2	-0.1	-0.4
Intraocular pressure	0.4	0.6	1.1	-0.4	1.1
Delta distance traveled before/after self-admin	0.5	0.6	0.7	-0.6	0.8
Delta ambulatory time before/after self-admin	0.8	1.0	1.1	-0.9	1.0
Parametrial fat weight	1.1	2.5	3.3	-1.8	-1.3
Pavlov. Cond. lever latency	1.1	1.4	1.4	-1.2	1.2
Pavlov. Cond. magazine entry latency	1.2	1.6	1.7	1.3	-1.2
Pavlov. Cond. change in total contacts	0.4	0.4	0.5	0.7	-0.6
Pavlov. Cond. index score	0.6	0.7	1.2	1.1	-0.5
Pavlov. Cond. latency score	0.6	0.8	1.0	1.0	-0.8
Pavlov. Cond. lever contacts	0.8	1.0	1.3	0.8	-1.2
Pavlov. Cond. magazine entry number	0.6	0.7	1.4	-1.2	0.0
Pavlov. Cond. intertrial magazine entries	0.4	0.5	1.0	0.2	1.0
Pavlov. Cond. lever-magazine prob. diff.	0.6	0.8	1.2	1.1	-0.6
Pavlov. Cond. response bias	0.7	0.9	1.5	1.2	-0.6
Pavlov. Cond. lever latency	0.5	0.7	0.9	-0.9	0.7
Pavlov. Cond. magazine entry latency	3.2	3.8	7.4	2.7	-0.6
Pavlov. Cond. change in total contacts	0.9	1.4	2.6	1.6	-0.5
Pavlov. Cond. index score	1.9	2.5	4.5	2.1	-0.8
Pavlov. Cond. latency score	1.8	2.4	4.0	2.0	-0.9
Pavlov. Cond. lever contacts	0.4	0.5	0.8	0.9	-0.4
Pavlov. Cond. magazine entry number	4.7	5.8	11.1	-3.3	0.7
Pavlov. Cond. intertrial magazine entries	1.1	1.7	2.3	-1.5	1.1
Pavlov. Cond. lever-magazine prob. diff.	2.2	2.9	5.2	2.3	-0.7
Pavlov. Cond. response bias	1.5	2.0	3.4	1.8	-0.8
Time in closed arm before self-admin	0.0	0.0	0.1	-0.2	-0.3
Time in closed arm after self-admin	0.6	0.6	1.3	-1.1	0.0
Time in open arm before self-admin	0.6	0.7	1.2	-1.1	0.4
Time in open arm after self-admin	0.3	0.3	0.6	0.8	0.1
Bone: periosteal estimation	1.0	2.1	4.2	0.0	-2.0
Bone: periosteal perimeter	0.4	0.7	1.4	0.1	-1.2
Bone: post-yield work	2.3	3.3	6.7	0.0	-2.6
Progressive ratio test 1 active lever presses	0.3	0.3	0.4	-0.6	-0.5
Progressive ratio test 1 breakpoint	0.3	0.3	0.4	-0.6	-0.5
Progressive ratio test 1 inactive lever presses	0.6	0.8	1.0	0.7	-1.0
Progressive ratio test 2 active lever presses	0.6	0.7	0.9	-1.0	-0.7
Progressive ratio test 2 breakpoint	0.6	0.7	0.8	-0.9	-0.7
Progressive ratio test 2 inactive lever presses	0.4	0.7	0.8	-0.8	-0.9
Incentive Sensitization - Responses	0.9	1.3	1.9	0.8	-1.4
Incentive Sensitization - Breakpoint	0.9	1.1	1.8	0.7	-1.4
Sum of active levers in priming session hrs 5-6	1.5	1.4	1.4	1.2	1.2
Progressive ratio	0.5	0.7	1.4	-0.2	-1.2
Food seeking constrained by brief footshock	0.0	0.0	0.1	-0.3	-0.1
Seeking ratio, punishment vs. effort	0.1	0.1	0.2	-0.1	0.4
Retroperitoneal fat weight	2.1	8.9	17.4	-4.2	-0.5
Reaction time number correct	0.1	0.3	0.5	0.7	-0.1
Reaction time mean minus median	0.4	1.0	1.3	0.9	1.1
Reaction time mean minus median AUC	0.7	1.7	3.1	0.5	1.8
Reaction time num false alarms	0.3	0.4	0.4	-0.6	0.6
Reaction time num false alarms AUC	0.2	0.3	0.6	-0.1	0.7
Reaction time trials correct on left	0.1	0.3	0.5	0.7	-0.1
Reaction time trials on left	0.2	0.3	0.6	0.8	0.0
Reaction time mean	0.3	0.5	1.0	0.1	1.0
Reaction time mean AUC	0.3	0.5	1.0	-0.1	1.0
Median of all reaction times	0.1	0.1	0.2	0.1	0.4
Reaction time omissions	0.7	1.0	1.4	0.8	1.2
Reaction time false alarm rate	0.2	0.2	0.3	-0.5	0.4
Reaction time premature initiation rate	3.3	4.6	5.8	2.4	-1.9
Reaction time premature initiations	2.5	4.5	7.3	2.7	-1.3
Std. dev. reaction times	0.9	1.7	3.3	0.1	1.8
Reaction time trials completed	0.2	0.3	0.6	0.8	0.0
Reaction time trials AUC	0.1	0.2	0.4	0.7	-0.1
Run reversals in cocaine runway, females	1.7	1.7	3.3	0.4	-1.8
Run reversals in cocaine runway, males	0.5	0.5	0.6	-0.7	0.7
Latency to leave start box in cocaine runway	0.7	0.8	1.0	-0.8	-1.0
Latency to leave start box in cocaine runway, F	0.2	0.3	0.5	0.1	-0.7
Latency to leave start box in cocaine runway, M	1.3	1.2	2.3	-1.5	-0.3
Std. dev. time between licks in bursts	0.1	0.1	0.2	-0.4	-0.1
Total sessions with >9 infusions	0.5	0.6	1.0	-1.0	-0.5
Short access day 1 total inactive lever presses	0.5	0.6	1.2	-0.2	-1.1
Short access day 10 total inactive lever presses	0.3	0.6	0.8	-0.9	0.7
Short access day 1 total infusions	0.8	1.1	1.7	-1.3	-0.7
Short access day 10 total infusions	1.6	2.0	3.7	-0.5	-1.9
Short access total infusions	1.2	1.5	2.2	-0.9	-1.5
Short access day 1 locomotion	0.3	0.4	0.6	-0.5	-0.8
Short access day 10 total locomotion	0.7	1.4	2.7	0.2	-1.6
Short access total locomotion	0.8	0.9	1.8	-0.3	-1.3
One hour access (0.3 mA shock)	1.0	1.1	1.2	-1.1	-1.0
Compulsive drug intake	0.6	0.7	0.8	0.9	0.7
One hour access (shock baseline)	1.5	2.2	4.0	-2.0	-0.6
Social response proportion	0.0	0.0	0.0	-0.1	0.1
Social responses	0.4	0.5	1.1	0.1	1.0
Social time	0.4	0.6	1.1	-0.2	1.0
Soleus weight	1.8	5.3	9.9	-3.1	0.9
Bone: stiffness	0.6	1.0	1.1	1.1	-0.9
Tibialis anterior weight	5.4	18.3	34.0	5.8	-1.6
Time to tail flick, vehicle, before self-admin	0.9	0.9	1.7	0.4	-1.3
Time to tail flick, vehicle, after self-admin	0.6	0.8	1.4	0.5	-1.2
Time to tail flick, test, before self-admin	2.2	2.3	4.3	0.5	-2.1
Time to tail flick, test, after self-admin	0.0	0.0	0.0	0.2	0.1
Delta time to tail flick, vehicle, before/after SA	0.1	0.1	0.2	0.4	-0.2
Delta time to tail flick, test, before/after SA	1.9	1.9	3.8	0.0	2.0
Tibia length	0.8	2.2	3.9	2.0	-0.7
Ambulatory time before self-admin	1.1	1.6	2.8	1.7	-0.6
Ambulatory time after self-admin	0.1	0.2	0.3	0.6	-0.0
Bone: tissue strength	0.3	0.3	0.5	-0.7	0.3
Total heroin consumption	3.6	4.2	8.3	2.9	0.4
Bone: trabecular number	1.8	2.9	3.6	1.5	-1.9
Bone: trabecular spacing	1.0	1.4	1.9	-0.9	1.4
Bone: trabecular thickness	0.0	0.0	0.0	-0.2	-0.1
Bone: trabecular tissue density	4.3	6.4	7.9	-2.8	2.2
Water consumed over 24 hours	0.2	0.3	0.5	0.7	0.2
Number of responses in last shaping day	0.1	0.1	0.1	0.3	-0.2