Hub : Genes

Zbtb3

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	BLA	gene expression	Zbtb3	0.04	0.03	7.8e-03	0.03	0.03	0.03	0.03	6.4e-03	9.3e-03	7.3e-03	1.0e-02
2	Adipose	alternative polyA	NM_001109162.2	0.03	0.02	6.3e-04	0.03	0.01	0.02	0.02	3.7e-04	8.2e-03	3.4e-03	4.0e-03
3	Adipose	alternative polyA	XM_006230992.4	0.03	0.02	1.0e-03	0.03	0.01	0.02	0.01	5.7e-04	9.4e-03	5.5e-03	9.4e-03
4	Liver	alternative polyA	NM_001109162.2	0.04	0.03	9.9e-03	0	0.01	0	0	1.4e-01	3.0e-02	3.1e-01	2.3e-01

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bone: apparent density	0.3	0.5	1.0	0.5	0.7	-0.7	-1.0
Area under the delay curve	0.2	0.2	0.9	0.0	0.0	-0.0	-1.0
BMI with tail	2.9	9.4	16.1	2.8	2.6	-2.6	-4.0
BMI without tail	1.3	2.6	4.9	1.5	1.3	-1.3	-2.2
Body weight	3.8	15.9	18.0	4.2	3.9	-3.9	-4.0
Weight adjusted by age	1.5	1.7	2.2	1.5	1.4	-1.4	-0.8
Bone surface	1.7	3.1	3.7	1.8	1.9	-1.9	-1.3
Bone volume	0.7	1.2	1.5	1.1	1.2	-1.2	-0.8
Breakpoint value in progressive ratio session	1.7	1.9	2.6	1.5	1.6	-1.6	0.1
Number of licking bursts	0.0	0.0	0.0	0.1	-0.1	0.1	-0.1
Context. condit. distance diff. score	0.5	0.6	0.8	-0.9	-0.8	0.8	-0.7
Locomotion velocity, session 1	0.2	0.3	1.0	-0.2	-0.1	0.1	-1.0
Locomotion distance, session 1	0.8	1.0	3.0	0.5	0.6	-0.6	-1.7
Locomotion velocity, session 2	2.5	2.9	3.1	1.8	1.7	-1.7	-1.6
Locomotion distance, session 2	0.2	0.3	0.9	0.3	0.3	-0.3	-0.9
Locomotion velocity, session 3	0.8	1.0	3.4	0.5	0.3	-0.3	-1.8
Locomotion distance, session 3	0.1	0.1	0.4	0.3	0.2	-0.2	-0.6
Stereotopy head waving bouts, day 3	0.5	0.6	1.7	-0.5	-0.5	0.5	-1.3
Stereotopy head waving duration, day 3	0.4	0.5	0.9	-0.6	-0.6	0.6	-1.0
Locomotion velocity, session 7	0.1	0.1	0.2	-0.3	-0.3	0.3	-0.4
Locomotion distance, session 7	0.3	0.4	0.9	-0.5	-0.5	0.5	-1.0
Stereotopy head waving bouts, day 7	0.1	0.1	0.1	0.3	0.3	-0.3	-0.1
Stereotopy head waving duration, day 7	1.8	2.1	2.7	1.6	1.6	-1.6	-1.0
Locomotion velocity, session 8	0.1	0.1	0.2	-0.4	-0.3	0.3	-0.4
Locomotion distance, session 8	0.4	0.6	0.7	-0.8	-0.7	0.7	-0.8
Degree of sensitization distance	0.4	0.4	1.1	-0.4	-0.3	0.3	-1.1
Degree of sensitization stereotypy	0.7	0.8	1.2	1.1	1.0	-1.0	-0.1
Conditioned locomotion	0.6	0.7	0.8	0.8	0.9	-0.9	-0.7
Cocaine response after cond. corrected	0.7	0.8	1.5	-1.2	-0.9	0.9	-0.5
Cocaine response after cond. not corrected	0.5	0.6	1.1	-1.0	-0.7	0.7	-0.3
Cocaine response before conditioning	0.4	0.5	0.7	0.8	0.6	-0.6	0.6
Saline control response	2.4	3.2	3.9	2.0	1.8	-1.8	-1.5
Bone: connectivity density	1.7	2.7	3.2	1.6	1.6	-1.6	-1.8
Bone: cortical apparent density	0.3	0.4	0.6	0.7	0.8	-0.8	0.0
Bone: cortical area	0.8	1.1	1.6	1.3	1.2	-1.2	-0.6
Bone: cortical porosity	0.2	0.2	0.5	-0.3	-0.2	0.2	0.7
Bone: cortical porosity	0.1	0.1	0.2	0.0	0.2	-0.2	0.4
Bone: cortical thickness	2.5	4.1	5.7	2.4	2.2	-2.2	-1.0
Bone: cortical thickness	0.4	0.5	0.6	0.7	0.7	-0.7	-0.5
Bone: cortical tissue density	0.4	0.5	0.7	0.8	0.8	-0.8	0.0
Condit. Reinf. active minus inactive responses	0.9	1.0	1.2	1.1	1.1	-1.1	-0.7
Condit. Reinf. active-inactive response ratio	0.4	0.4	0.6	0.6	0.7	-0.7	-0.2
Condit. Reinf. active responses	0.8	0.9	1.2	1.1	1.0	-1.0	-0.7
Condit. Reinf. inactive responses	0.0	0.0	0.0	0.1	-0.0	0.0	0.0
Incentive salience index mean	1.3	1.6	1.7	1.3	1.2	-1.2	-1.2
Condit. Reinf. lever presses	0.8	1.1	1.6	1.1	0.9	-0.9	-1.3
Condit. Reinf. active minus inactive responses	0.5	0.6	1.6	-0.5	-0.6	0.6	1.3
Condit. Reinf. active-inactive response ratio	0.8	0.8	1.4	-0.8	-0.8	0.8	1.2
Condit. Reinf. active responses	0.0	0.1	0.2	0.2	0.0	-0.0	0.4
Condit. Reinf. inactive responses	0.2	0.2	0.2	0.4	0.4	-0.4	-0.5
Condit. Reinf. lever presses	0.9	1.2	1.6	1.3	1.2	-1.2	-0.3
Condit. Reinf. lever reinforcers received	0.1	0.2	0.2	0.5	0.4	-0.4	0.4
Conditioned reinforcement - actives	2.3	2.3	3.4	-1.5	-1.4	1.4	1.8
Conditioned reinforcement - inactives	0.7	0.8	0.9	-0.9	-1.0	1.0	0.8
Conditioned locomotion	1.5	1.8	2.4	-1.5	-1.5	1.5	0.5
Patch foraging indifference point 0 sec	0.5	0.8	0.9	0.9	0.9	-0.9	-0.8
Patch foraging indifference point AUC	2.2	2.5	3.3	1.8	1.8	-1.8	0.1
Delay disc. indifference point, 0s delay	0.6	0.7	1.5	-0.6	-0.7	0.7	-1.2
Delay disc. indifference point, 16s delay	0.2	0.2	0.3	0.3	0.3	-0.3	-0.6
Delay disc. indifference point, 2s delay	0.2	0.2	0.3	-0.5	-0.4	0.4	-0.4
Delay disc. indifference point, 24s delay	0.3	0.3	0.8	0.3	0.4	-0.4	-0.9
Delay disc. indifference point, 4s delay	0.8	0.8	2.9	0.4	0.4	-0.4	-1.7
Delay disc. indifference point, 8s delay	0.3	0.3	0.4	-0.6	-0.6	0.6	-0.4
Indifference point function ln k	3.1	4.4	6.1	-2.5	-2.3	2.3	-0.7
Indifference point function log k	3.1	4.4	6.1	-2.5	-2.3	2.3	-0.7
Patch foraging total patch changes 0 sec	0.5	0.8	0.9	0.9	0.9	-0.9	-0.9
Patch foraging total patch changes 12 sec	5.8	7.5	9.8	3.0	3.1	-3.1	-1.2
Patch foraging total patch changes 18 sec	0.5	0.7	1.1	0.7	1.0	-1.0	0.2
Patch foraging total patch changes 24 sec	7.4	9.0	10.5	3.1	3.2	-3.2	-2.3
Patch foraging total patch changes 6 sec	1.3	2.0	2.4	1.3	1.5	-1.5	-1.2
Patch foraging time to switch 0 sec	0.3	0.4	0.5	0.6	0.7	-0.7	-0.7
Patch foraging water rate 0 sec	0.3	0.5	0.6	-0.8	-0.7	0.7	0.6
Patch foraging water rate 12 sec	1.2	1.9	2.5	-1.5	-1.6	1.6	0.2
Patch foraging water rate 18 sec	0.7	0.9	1.0	-1.0	-0.9	0.9	-1.0
Patch foraging water rate 24 sec	1.1	1.5	2.2	-1.5	-1.3	1.3	0.3
Patch foraging water rate 6 sec	1.0	1.4	2.0	-1.3	-1.4	1.4	0.0
Seeking ratio, delayed vs. immediate footshock	0.0	0.0	0.1	0.0	0.1	-0.1	-0.4
Distance traveled before self-admin	2.1	2.3	3.1	1.7	1.7	-1.7	-0.5
Distance traveled after self-admin	0.4	0.4	0.6	0.7	0.7	-0.7	0.4
Extensor digitorum longus weight	6.5	25.7	29.8	5.5	5.2	-5.2	-4.3
Bone: elastic displacement	0.5	0.6	0.7	-0.8	-0.8	0.8	0.6
Bone: elastic work	0.7	0.9	1.1	0.9	1.0	-1.0	-1.0
Bone: endosteal estimation	0.8	1.7	2.5	-1.6	-1.4	1.4	-0.2
Bone: endosteal perimeter	1.2	2.4	3.2	-1.8	-1.7	1.7	0.6
Epididymis fat weight	0.2	0.5	0.8	-0.6	-0.9	0.9	-0.5
Delta time in closed arm before/after self-admin	2.2	2.2	5.6	1.0	1.0	-1.0	-2.4
Delta time in open arm before/after self-admin	1.3	1.3	1.7	1.3	1.3	-1.3	0.1
Diff in mean of infusions in LGA sessions	1.3	1.5	2.0	1.4	1.4	-1.4	-0.1
Delay discount exponential model param	0.2	0.2	0.8	-0.0	-0.1	0.1	0.9
Extinction: sum of active levers before priming	3.7	3.7	4.7	2.1	2.2	-2.2	-1.0
Active lever presses in extinction session 6	2.2	2.1	3.1	1.8	1.6	-1.6	0.1
Bone: final force	2.0	3.3	3.6	1.9	1.9	-1.9	-1.6
Bone: final moment	2.0	3.2	3.5	1.9	1.9	-1.9	-1.5
Food consumed during 24 hour testing period	0.1	0.2	0.6	-0.1	-0.0	0.0	0.8
Glucose	2.3	3.4	4.5	-2.0	-2.1	2.1	0.8
Heart weight	0.8	1.1	1.4	-1.2	-1.2	1.2	-0.6
Delay discount hyperbolic model param	0.2	0.2	1.0	-0.0	-0.1	0.1	1.0
Intermittent access intake day 1-15 change	2.2	2.2	5.2	-1.2	-1.0	1.0	2.3
Intermittent access intake escalation	1.4	1.4	3.7	-0.9	-0.7	0.7	1.9
Intermittent access intake escalation 2	0.5	0.5	1.8	-0.1	0.0	-0.0	1.3
Intermitt. access day 1 inactive lever presses	2.0	2.1	2.8	-1.5	-1.7	1.7	0.9
Intermitt. access day 15 inactive lever presses	0.1	0.1	0.1	0.3	0.1	-0.1	-0.4
Intermitt. access escalation Index	0.4	0.3	0.6	-0.5	-0.5	0.5	-0.8
Intermittent access day 1 total infusions	0.8	0.9	1.4	-0.9	-0.9	0.9	-1.2
Intermittent access day 15 total infusions	2.6	2.9	3.8	-1.9	-1.8	1.8	1.1
Intermittent access terminal intake (last 3 days)	0.3	0.3	0.6	-0.7	-0.6	0.6	0.2
Intermittent access total infusions	0.6	0.6	1.0	-1.0	-0.9	0.9	-0.0
Intermittent access day 1 locomotion	1.0	1.1	3.9	-0.4	-0.3	0.3	-2.0
Intermittent access day 15 total locomotion	0.1	0.1	0.1	-0.3	-0.3	0.3	-0.4
Intermittent access total locomotion	0.4	0.4	1.6	-0.2	-0.2	0.2	-1.3
Intermittent access standard deviation	1.7	1.8	3.3	-1.2	-1.1	1.1	1.8
Left kidney weight	0.0	0.1	0.1	0.3	0.1	-0.1	-0.4
Right kidney weight	0.1	0.2	0.3	0.5	0.5	-0.5	-0.3
Cocaine induced anxiety	0.3	0.3	0.4	0.5	0.7	-0.7	0.0
Post-drug Anxiety	0.5	0.6	0.8	0.9	0.9	-0.9	0.2
Baseline Anxiety	0.8	0.9	1.2	1.1	1.0	-1.0	-0.7
Tail length	0.7	2.1	3.1	1.8	1.5	-1.5	-0.8
Length with tail	2.1	7.8	10.5	3.2	2.9	-2.9	-2.0
Length without tail	2.0	4.3	5.5	2.3	2.2	-2.2	-1.5
Times rat made contact with spout	0.1	0.1	0.1	0.3	0.4	-0.4	-0.2
Lifetime Intake	0.7	0.7	1.1	-1.0	-0.9	0.9	-0.4
Liver weight, left	0.2	0.3	0.5	-0.7	-0.5	0.5	0.4
Liver weight, right	0.1	0.2	0.8	0.0	0.2	-0.2	-0.9
Locomotor activity	0.6	0.9	1.2	-1.1	-1.1	1.1	0.1
Locomotor testing distance	0.8	1.3	1.7	-1.3	-1.3	1.3	-0.4
Locomotor testing rearing	0.8	1.2	1.7	-1.3	-1.3	1.3	0.1
Locomotion in novel chamber	1.8	2.2	2.5	-1.5	-1.6	1.6	1.3
Locomotion in novel chamber post-restriction	2.9	3.5	4.0	-1.9	-2.0	2.0	1.4
Fecal boli incidents, locomotor time 1	0.4	0.5	1.5	-0.3	-0.3	0.3	1.2
Change in fecal boli incidents, locomotor task	0.9	0.8	0.9	-0.9	-1.0	1.0	-0.8
Time >=10cm from walls, locomotor time 1	2.1	2.1	2.7	-1.3	-1.6	1.6	1.1
Bouts of movement, locomotor time 1	0.6	0.7	2.5	0.5	0.2	-0.2	1.6
Total resting periods, locomotor time 1	0.5	0.6	1.9	0.5	0.3	-0.3	1.4
Rest time, locomotor task time 1	1.3	1.4	1.8	-1.3	-1.0	1.0	1.4
Distance moved, locomotor task time 1	0.3	0.3	0.6	0.6	0.4	-0.4	-0.8
Vertical activity count, locomotor time 1	0.6	0.7	1.0	-0.8	-1.0	1.0	0.3
Time >=10cm from walls, locomotor time 2	0.4	0.4	1.6	-0.1	-0.2	0.2	1.3
Bouts of movement, locomotor time 2	1.3	1.3	1.8	1.3	1.3	-1.3	-0.4
Total resting periods, locomotor time 2	0.6	0.7	1.0	0.9	1.0	-1.0	-0.2
Rest time, locomotor task time 2	2.8	3.2	4.5	-2.1	-1.9	1.9	1.3
Distance moved, locomotor task time 2	0.4	0.4	0.7	0.9	0.7	-0.7	0.2
Vertical activity count, locomotor time 2	0.1	0.1	0.1	-0.1	-0.3	0.3	0.4
Light reinforcement 1	0.1	0.2	0.5	-0.3	-0.3	0.3	0.7
Light reinforcement 2	0.3	0.4	1.1	-0.3	-0.5	0.5	1.1
Bone: marrow area	0.9	1.9	2.9	-1.7	-1.6	1.6	-0.1
Bone: maximum diameter	0.1	0.2	0.3	0.5	0.5	-0.5	-0.2
Bone: maximum force	2.8	4.8	4.9	2.2	2.2	-2.2	-2.2
Bone: maximum moment	2.6	4.5	4.7	2.2	2.1	-2.1	-2.1
Mean time between licks in bursts	1.0	1.4	2.9	0.9	1.0	-1.0	-1.7
Mean num. licks in bursts	0.0	0.0	0.1	-0.2	-0.0	0.0	0.2
Cd content in liver	1.1	1.2	1.9	-1.4	-0.9	0.9	1.0
Co content in liver	1.8	2.1	2.6	-1.6	-1.4	1.4	1.3
Cu content in liver	0.2	0.3	0.4	0.4	0.5	-0.5	-0.7
Fe content in liver	0.0	0.0	0.0	-0.1	-0.1	0.1	0.1
K content in liver	1.1	1.1	1.5	1.2	0.9	-0.9	-1.2
Mg content in liver	0.6	0.6	1.6	0.7	0.4	-0.4	-1.3
Mn content in liver	2.1	2.4	3.3	1.8	1.6	-1.6	-0.8
Na content in liver	0.5	0.5	0.9	0.9	0.7	-0.7	-0.3
Rb content in liver	1.3	1.7	2.3	-1.4	-1.5	1.5	0.0
Se content in liver	0.2	0.2	0.4	0.6	0.5	-0.5	0.2
Sr content in liver	5.1	4.7	5.9	2.4	2.4	-2.4	-1.0
Zn content in liver	3.8	4.2	5.0	2.2	2.2	-2.2	-1.3
Bone: minimum diameter	0.3	0.6	0.8	-0.9	-0.9	0.9	-0.3
Time in familiar zone, hab. session 1	0.2	0.2	0.3	0.3	0.4	-0.4	-0.5
Time in novel zone, hab. session 1	1.4	1.3	1.7	-1.2	-1.3	1.3	0.7
Total zone transitions, hab. session 1	0.2	0.2	0.3	0.5	0.5	-0.5	-0.4
Total locomotion distance, hab. session 1	0.1	0.1	0.1	-0.4	-0.3	0.3	-0.3
Locomotion velocity, hab. session 1	0.1	0.1	0.2	0.2	0.2	-0.2	-0.4
Time in familiar zone, hab. session 2	0.2	0.2	0.4	-0.3	-0.4	0.4	0.6
Time in novel zone, hab. session 2	0.6	0.6	1.1	0.6	0.6	-0.6	-1.1
Total zone transitions, hab. session 2	1.6	2.1	3.3	1.3	1.3	-1.3	-1.8
Total locomotion distance, hab. session 2	0.3	0.3	1.2	0.2	0.2	-0.2	-1.1
Locomotion velocity, hab. session 2	0.2	0.2	0.8	0.1	0.1	-0.1	-0.9
Novel to familiar place preference ratio	1.9	2.0	2.6	1.6	1.5	-1.5	-0.9
Novelty place preference	1.1	1.2	1.6	1.3	1.2	-1.2	-0.6
Time in novel zone, NPP test	1.2	1.3	1.7	1.3	1.2	-1.2	-0.7
Total zone transitions, NPP test	1.0	1.5	1.8	1.1	1.2	-1.2	-1.4
Total locomotion distance, NPP test	0.1	0.2	0.8	-0.0	0.0	-0.0	-0.9
Locomotion velocity, NPP test	0.1	0.1	0.3	-0.1	-0.1	0.1	-0.6
Intraocular pressure	0.2	0.3	1.1	-0.2	-0.3	0.3	1.0
Delta distance traveled before/after self-admin	0.4	0.5	0.7	-0.8	-0.7	0.7	0.4
Delta ambulatory time before/after self-admin	0.8	0.8	1.2	-1.1	-1.0	1.0	0.5
Parametrial fat weight	1.1	2.1	2.7	-1.6	-1.7	1.7	0.5
Pavlov. Cond. lever latency	1.2	1.6	1.6	-1.3	-1.2	1.2	1.3
Pavlov. Cond. magazine entry latency	1.0	1.3	1.6	1.3	1.2	-1.2	-0.6
Pavlov. Cond. change in total contacts	0.3	0.3	0.4	0.6	0.6	-0.6	0.2
Pavlov. Cond. index score	0.6	0.7	0.9	1.0	1.0	-1.0	-0.2
Pavlov. Cond. latency score	0.5	0.6	0.8	0.9	0.9	-0.9	-0.5
Pavlov. Cond. lever contacts	0.3	0.3	0.3	0.6	0.6	-0.6	-0.6
Pavlov. Cond. magazine entry number	0.7	0.8	1.1	-1.0	-1.0	1.0	-0.3
Pavlov. Cond. intertrial magazine entries	0.2	0.2	0.8	0.1	0.0	-0.0	0.9
Pavlov. Cond. lever-magazine prob. diff.	0.7	0.9	1.2	1.1	1.1	-1.1	-0.2
Pavlov. Cond. response bias	0.7	0.8	1.1	1.0	1.0	-1.0	-0.1
Pavlov. Cond. lever latency	0.5	0.7	0.8	-0.8	-0.9	0.9	0.6
Pavlov. Cond. magazine entry latency	4.0	4.6	5.9	2.4	2.4	-2.4	-0.9
Pavlov. Cond. change in total contacts	1.5	2.1	2.9	1.6	1.7	-1.7	-0.0
Pavlov. Cond. index score	2.5	3.3	4.3	2.0	2.1	-2.1	-0.7
Pavlov. Cond. latency score	2.3	2.8	3.7	1.9	1.9	-1.9	-0.7
Pavlov. Cond. lever contacts	0.4	0.6	0.8	0.8	0.9	-0.9	0.0
Pavlov. Cond. magazine entry number	6.7	8.2	10.6	-3.2	-3.3	3.3	1.3
Pavlov. Cond. intertrial magazine entries	1.8	2.4	2.6	-1.6	-1.6	1.6	1.4
Pavlov. Cond. lever-magazine prob. diff.	2.9	3.7	4.9	2.1	2.2	-2.2	-0.7
Pavlov. Cond. response bias	1.6	2.2	3.0	1.6	1.7	-1.7	-0.5
Time in closed arm before self-admin	0.1	0.1	0.4	-0.1	-0.0	0.0	0.6
Time in closed arm after self-admin	0.5	0.5	0.7	-0.8	-0.8	0.8	-0.2
Time in open arm before self-admin	0.8	0.9	1.1	-1.0	-1.1	1.1	-0.5
Time in open arm after self-admin	0.1	0.1	0.1	0.1	0.2	-0.2	0.3
Bone: periosteal estimation	0.0	0.1	0.2	-0.1	-0.0	0.0	-0.5
Bone: periosteal perimeter	0.0	0.0	0.0	0.0	0.0	-0.0	0.1
Bone: post-yield work	0.1	0.1	0.2	-0.5	-0.2	0.2	-0.4
Progressive ratio test 1 active lever presses	1.8	1.9	2.4	-1.5	-1.5	1.5	0.9
Progressive ratio test 1 breakpoint	2.2	2.3	2.7	-1.6	-1.6	1.6	1.1
Progressive ratio test 1 inactive lever presses	0.2	0.2	1.0	0.1	0.0	-0.0	-1.0
Progressive ratio test 2 active lever presses	1.4	1.5	1.8	-1.3	-1.3	1.3	0.8
Progressive ratio test 2 breakpoint	2.5	2.8	3.1	-1.8	-1.7	1.7	1.4
Progressive ratio test 2 inactive lever presses	0.5	0.6	0.9	-0.8	-0.9	0.9	0.2
Incentive Sensitization - Responses	0.1	0.1	0.1	0.3	0.3	-0.3	-0.3
Incentive Sensitization - Breakpoint	0.0	0.0	0.0	0.2	0.2	-0.2	-0.2
Sum of active levers in priming session hrs 5-6	1.4	1.4	1.7	1.1	1.1	-1.1	1.3
Progressive ratio	0.0	0.0	0.1	0.3	0.2	-0.2	-0.1
Food seeking constrained by brief footshock	0.1	0.1	0.2	-0.3	-0.5	0.5	-0.2
Seeking ratio, punishment vs. effort	0.1	0.2	0.3	-0.5	-0.4	0.4	-0.4
Retroperitoneal fat weight	1.9	6.2	8.2	-2.8	-2.9	2.9	0.5
Reaction time number correct	0.6	0.9	1.2	1.1	0.9	-0.9	-0.7
Reaction time mean minus median	0.7	0.9	1.8	0.6	0.8	-0.8	1.3
Reaction time mean minus median AUC	0.5	0.6	2.0	0.3	0.5	-0.5	1.4
Reaction time num false alarms	0.2	0.3	0.5	-0.7	-0.5	0.5	-0.2
Reaction time num false alarms AUC	0.1	0.1	0.3	-0.2	0.1	-0.1	-0.5
Reaction time trials correct on left	0.6	0.9	1.2	1.1	0.9	-0.9	-0.7
Reaction time trials on left	0.6	0.9	1.3	1.1	1.0	-1.0	-0.7
Reaction time mean	0.4	0.5	1.9	-0.3	0.0	-0.0	1.4
Reaction time mean AUC	0.4	0.6	2.1	-0.4	-0.1	0.1	1.4
Median of all reaction times	0.1	0.1	0.5	-0.1	0.2	-0.2	0.7
Reaction time omissions	0.2	0.3	0.7	0.0	0.4	-0.4	0.8
Reaction time false alarm rate	0.2	0.3	0.7	-0.8	-0.5	0.5	-0.2
Reaction time premature initiation rate	4.4	5.9	7.5	2.4	2.3	-2.3	-2.7
Reaction time premature initiations	5.4	7.6	8.5	2.9	2.7	-2.7	-2.7
Std. dev. reaction times	0.7	1.0	3.8	-0.3	-0.0	0.0	1.9
Reaction time trials completed	0.6	0.9	1.3	1.1	1.0	-1.0	-0.7
Reaction time trials AUC	0.5	0.7	1.0	1.0	0.8	-0.8	-0.7
Run reversals in cocaine runway, females	2.1	2.0	6.1	0.8	0.8	-0.8	-2.5
Run reversals in cocaine runway, males	0.6	0.6	0.7	-0.8	-0.8	0.8	0.7
Latency to leave start box in cocaine runway	0.2	0.2	0.3	-0.6	-0.4	0.4	-0.4
Latency to leave start box in cocaine runway, F	0.0	0.0	0.1	0.1	0.2	-0.2	-0.3
Latency to leave start box in cocaine runway, M	2.7	2.5	3.5	-1.9	-1.7	1.7	0.8
Std. dev. time between licks in bursts	0.1	0.2	0.3	-0.4	-0.3	0.3	-0.6
Total sessions with >9 infusions	1.3	1.5	2.2	-1.5	-1.3	1.3	-0.4
Short access day 1 total inactive lever presses	0.7	0.8	1.0	-1.0	-1.0	1.0	-0.6
Short access day 10 total inactive lever presses	2.2	2.4	3.3	-1.7	-1.8	1.8	0.3
Short access day 1 total infusions	0.8	0.8	1.2	-1.1	-1.0	1.0	-0.5
Short access day 10 total infusions	0.5	0.6	1.8	-0.5	-0.4	0.4	-1.4
Short access total infusions	0.6	0.7	1.3	-0.8	-0.7	0.7	-1.1
Short access day 1 locomotion	0.7	0.8	3.0	0.1	0.2	-0.2	-1.7
Short access day 10 total locomotion	0.4	0.4	1.6	0.0	0.0	-0.0	-1.3
Short access total locomotion	1.0	1.0	3.8	0.3	0.3	-0.3	-1.9
One hour access (0.3 mA shock)	3.4	3.9	4.9	-2.2	-2.2	2.2	1.1
Compulsive drug intake	0.9	0.9	1.1	1.0	0.9	-0.9	-1.0
One hour access (shock baseline)	4.8	5.6	6.1	-2.5	-2.4	2.4	2.2
Social response proportion	0.2	0.2	0.2	0.5	0.3	-0.3	-0.4
Social responses	0.1	0.1	0.1	0.3	0.2	-0.2	0.3
Social time	0.0	0.0	0.1	-0.1	-0.1	0.1	0.3
Soleus weight	2.5	7.4	9.2	-3.0	-3.0	3.0	1.5
Bone: stiffness	0.8	1.2	1.6	1.3	1.2	-1.2	-0.6
Tibialis anterior weight	9.1	31.1	37.7	6.1	6.0	-6.0	-3.8
Time to tail flick, vehicle, before self-admin	0.7	0.7	1.4	0.6	0.7	-0.7	-1.2
Time to tail flick, vehicle, after self-admin	0.7	0.8	2.0	0.6	0.6	-0.6	-1.4
Time to tail flick, test, before self-admin	1.3	1.2	4.2	0.4	0.6	-0.6	-2.0
Time to tail flick, test, after self-admin	0.1	0.1	0.1	-0.4	-0.3	0.3	0.3
Delta time to tail flick, vehicle, before/after SA	0.0	0.0	0.1	0.0	-0.0	0.0	-0.3
Delta time to tail flick, test, before/after SA	0.9	0.8	3.0	-0.1	-0.2	0.2	1.7
Tibia length	1.2	3.4	5.4	2.3	2.0	-2.0	-0.4
Ambulatory time before self-admin	1.6	1.7	2.7	1.6	1.4	-1.4	0.0
Ambulatory time after self-admin	0.3	0.3	0.4	0.6	0.7	-0.7	0.2
Bone: tissue strength	0.2	0.2	0.2	-0.2	-0.5	0.5	0.3
Total heroin consumption	3.1	3.6	4.8	2.2	2.2	-2.2	-0.3
Bone: trabecular number	0.8	1.2	1.6	1.0	1.1	-1.1	-1.3
Bone: trabecular spacing	0.3	0.4	0.4	-0.5	-0.6	0.6	0.6
Bone: trabecular thickness	0.3	0.3	0.5	-0.6	-0.4	0.4	0.7
Bone: trabecular tissue density	4.5	6.3	7.4	-2.7	-2.6	2.6	2.1
Water consumed over 24 hours	0.4	0.5	0.6	0.8	0.8	-0.8	-0.3
Number of responses in last shaping day	0.1	0.1	0.3	-0.2	0.1	-0.1	-0.5