Hub : Genes

Zfp280d

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Liver intron excision ratio chr8_73069456_73076974 0.02 0.02 6.7e-03 0.02 0.01 0.01 0.01 5.6e-03 1.3e-02 4.5e-02 1.4e-02
2 pVTA mRNA stability Zfp280d 0.14 0.09 1.3e-04 0.08 0.08 0.07 0.07 2.7e-04 2.0e-04 6.5e-04 5.8e-04
3 Adipose gene expression Zfp280d 0.07 0.04 1.4e-06 0.03 0.04 0.03 0.03 1.9e-04 5.4e-05 1.6e-04 1.0e-04
4 LHb mRNA stability Zfp280d 0.41 0.15 6.1e-08 0.31 0.31 0.35 0.35 4.5e-08 4.3e-08 3.0e-09 3.8e-09
5 Brain gene expression Zfp280d 0.07 0.05 1.4e-06 0.05 0.07 0.04 0.06 1.0e-05 5.5e-07 9.9e-05 2.6e-06
6 PL mRNA stability Zfp280d 0.19 0.09 0.0e+00 0.2 0.21 0.2 0.2 2.8e-21 2.0e-22 4.8e-21 1.0e-21
7 Brain intron excision ratio chr8_73039906_73041607 0.03 0.02 5.0e-03 0.02 0.01 0.01 0.01 2.3e-03 5.2e-02 4.8e-02 4.9e-02
8 LHb gene expression Zfp280d 0.22 0.12 6.5e-04 0.06 0.12 0.07 0.09 1.8e-02 1.1e-03 8.4e-03 3.4e-03
9 NAcc alternative TSS XM_006243357.4 0.03 0.03 6.3e-03 0.01 0.01 0.01 0.01 3.9e-02 1.6e-02 1.7e-02 1.7e-02
10 RMTg gene expression Zfp280d 0.14 0.1 4.2e-03 0.1 0.07 0.07 0.1 1.3e-03 4.9e-03 6.3e-03 1.4e-03
11 NAcc mRNA stability Zfp280d 0.25 0.13 0.0e+00 0.21 0.2 0.19 0.2 2.2e-23 6.2e-23 6.8e-22 1.5e-22
12 BLA mRNA stability Zfp280d 0.32 0.15 8.2e-11 0.15 0.18 0.18 0.17 1.8e-08 5.5e-10 9.6e-10 2.7e-09
13 Brain alternative polyA XM_006243357.4 0.07 0.05 1.9e-05 0.06 0.05 0.04 0.05 8.0e-06 1.2e-05 6.3e-05 2.0e-05
14 pVTA gene expression Zfp280d 0.17 0.1 1.4e-06 0.15 0.13 0.08 0.15 7.2e-07 3.7e-06 1.8e-04 5.4e-07

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14
Bone: apparent density0.40.70.9-0.0-0.80.80.90.9-0.90.80.9-0.8-1.00.8-0.90.90.9
Area under the delay curve1.31.32.0-1.1-0.60.81.31.0-1.11.31.2-1.4-1.31.1-1.01.31.3
BMI with tail0.93.012.7-3.63.3-2.5-0.3-1.91.4-0.7-0.9-0.50.6-0.61.9-0.6-0.6
BMI without tail1.73.46.3-1.12.5-2.4-1.6-2.11.9-1.8-1.81.01.6-1.62.4-1.7-1.7
Body weight0.62.515.0-3.93.0-2.20.2-1.40.9-0.1-0.4-1.10.2-0.11.5-0.0-0.0
Weight adjusted by age3.94.48.1-1.22.9-2.7-1.8-2.42.2-2.1-2.01.32.1-2.02.5-1.8-1.8
Bone surface0.00.00.2-0.40.3-0.3-0.0-0.20.2-0.1-0.1-0.00.1-0.10.2-0.1-0.1
Bone volume0.00.10.4-0.60.10.00.40.1-0.10.20.2-0.3-0.30.2-0.20.20.2
Breakpoint value in progressive ratio session0.00.10.4-0.60.1-0.00.20.1-0.10.10.1-0.3-0.20.20.10.10.1
Number of licking bursts0.20.32.01.4-0.90.6-0.40.4-0.2-0.30.00.50.2-0.2-0.3-0.2-0.2
Context. condit. distance diff. score1.01.21.6-0.1-1.11.11.31.1-1.11.11.1-0.9-1.21.2-1.31.21.2
Locomotion velocity, session 13.63.94.90.21.9-2.0-2.2-2.12.1-1.9-2.11.92.1-2.12.0-2.1-2.1
Locomotion distance, session 10.30.41.51.2-0.1-0.1-0.8-0.30.4-0.7-0.50.80.6-0.60.3-0.6-0.6
Locomotion velocity, session 20.40.50.7-0.60.7-0.6-0.5-0.70.6-0.1-0.80.50.8-0.80.7-0.8-0.8
Locomotion distance, session 20.50.71.00.20.8-0.9-0.9-0.80.8-0.7-0.90.70.9-1.01.0-0.9-0.9
Locomotion velocity, session 32.52.94.62.00.7-1.1-2.2-1.41.5-1.8-1.72.01.9-1.91.3-1.8-1.8
Locomotion distance, session 30.40.53.31.8-1.20.9-0.10.7-0.50.00.30.2-0.20.2-0.50.20.2
Stereotopy head waving bouts, day 30.50.61.00.20.9-0.9-0.9-0.90.9-1.0-0.70.60.7-0.80.8-0.7-0.7
Stereotopy head waving duration, day 30.80.91.3-0.21.1-1.1-1.0-1.11.1-1.1-1.00.90.9-1.00.9-0.9-0.9
Locomotion velocity, session 70.30.31.11.1-1.00.80.30.6-0.40.30.30.2-0.20.2-0.70.20.2
Locomotion distance, session 70.30.32.71.6-0.80.5-0.40.2-0.1-0.2-0.20.70.3-0.3-0.2-0.3-0.3
Stereotopy head waving bouts, day 71.51.72.30.51.3-1.4-1.4-1.41.4-1.5-1.31.11.3-1.31.4-1.2-1.2
Stereotopy head waving duration, day 72.02.42.90.41.5-1.6-1.7-1.61.6-1.6-1.61.51.7-1.71.5-1.6-1.6
Locomotion velocity, session 80.91.11.4-0.01.0-1.1-1.1-1.11.1-0.9-1.11.01.1-1.21.1-1.2-1.2
Locomotion distance, session 80.10.10.20.5-0.50.40.20.4-0.30.20.2-0.1-0.20.2-0.20.20.2
Degree of sensitization distance0.00.00.10.2-0.10.1-0.1-0.10.1-0.0-0.10.30.2-0.2-0.1-0.2-0.2
Degree of sensitization stereotypy1.01.11.30.21.1-1.2-1.1-1.11.1-1.1-1.10.91.1-1.11.1-1.0-1.0
Conditioned locomotion1.31.52.5-1.4-0.60.91.61.0-1.11.41.2-1.4-1.31.2-1.11.41.4
Cocaine response after cond. corrected2.22.53.7-0.71.9-1.8-1.4-1.91.8-1.4-1.71.51.5-1.51.3-1.6-1.6
Cocaine response after cond. not corrected1.31.42.1-0.71.4-1.3-1.0-1.51.4-1.0-1.31.21.2-1.20.8-1.2-1.2
Cocaine response before conditioning1.21.41.8-0.1-1.31.31.31.3-1.31.21.3-1.1-1.21.2-1.11.31.3
Saline control response0.70.91.90.80.3-0.6-1.2-0.80.9-1.2-1.01.41.1-1.10.6-1.0-1.0
Bone: connectivity density0.20.32.41.5-0.90.7-0.10.6-0.4-0.00.30.0-0.20.0-0.30.20.2
Bone: cortical apparent density0.10.21.11.0-0.60.50.00.3-0.20.20.10.2-0.10.1-0.50.10.1
Bone: cortical area0.10.10.5-0.7-0.00.20.50.0-0.00.40.10.1-0.20.2-0.70.20.2
Bone: cortical porosity1.31.42.3-0.7-1.21.31.41.2-1.21.51.1-0.9-1.11.0-1.41.11.1
Bone: cortical porosity2.72.94.5-0.8-1.71.82.01.8-1.82.11.7-1.5-1.71.6-1.91.71.7
Bone: cortical thickness0.61.02.40.6-1.31.31.01.0-0.91.00.9-0.4-0.90.8-1.60.90.9
Bone: cortical thickness0.30.31.00.4-0.90.80.50.5-0.50.60.40.1-0.30.3-1.00.30.3
Bone: cortical tissue density0.10.21.11.0-0.60.50.00.3-0.20.20.10.2-0.10.1-0.40.00.0
Condit. Reinf. active minus inactive responses2.32.64.2-1.3-0.91.21.91.5-1.72.01.7-2.1-1.71.7-1.01.71.7
Condit. Reinf. active-inactive response ratio3.33.55.1-1.0-1.51.72.31.8-1.92.21.9-2.0-2.02.0-1.82.02.0
Condit. Reinf. active responses0.30.41.3-0.9-0.00.20.70.5-0.60.90.6-1.1-0.60.60.10.60.6
Condit. Reinf. inactive responses1.72.03.50.71.2-1.4-1.7-1.31.3-1.4-1.41.11.6-1.51.9-1.5-1.5
Incentive salience index mean2.63.15.4-1.9-0.91.32.21.6-1.72.31.8-2.2-1.81.7-1.21.81.8
Condit. Reinf. lever presses1.52.04.0-1.8-0.81.11.81.2-1.42.01.4-1.7-1.31.3-1.01.41.4
Condit. Reinf. active minus inactive responses0.50.63.1-1.71.4-1.10.1-0.70.5-0.1-0.3-0.40.1-0.20.8-0.1-0.1
Condit. Reinf. active-inactive response ratio0.20.31.8-1.30.9-0.60.2-0.50.3-0.0-0.2-0.20.0-0.00.3-0.0-0.0
Condit. Reinf. active responses0.40.63.5-1.90.8-0.40.8-0.0-0.20.50.4-1.1-0.60.50.30.60.6
Condit. Reinf. inactive responses0.70.91.7-0.5-0.50.71.10.9-1.00.91.1-1.3-1.11.0-0.41.11.1
Condit. Reinf. lever presses0.60.81.20.1-0.91.01.10.9-0.90.90.9-0.7-0.90.9-1.10.90.9
Condit. Reinf. lever reinforcers received0.50.73.0-1.70.5-0.11.10.3-0.50.80.7-1.3-0.90.8-0.10.90.9
Conditioned reinforcement - actives0.20.20.30.30.1-0.2-0.5-0.30.4-0.5-0.40.50.4-0.50.3-0.4-0.4
Conditioned reinforcement - inactives0.20.20.80.90.1-0.2-0.5-0.30.4-0.5-0.40.70.5-0.60.1-0.5-0.5
Conditioned locomotion2.32.73.6-1.0-1.31.51.91.6-1.71.71.8-1.7-1.81.7-1.71.71.7
Patch foraging indifference point 0 sec0.81.31.80.21.0-1.1-1.3-1.21.2-1.1-1.21.21.3-1.01.0-1.2-1.2
Patch foraging indifference point AUC0.60.71.4-0.2-0.70.70.70.9-1.00.71.0-1.2-0.90.8-0.30.90.9
Delay disc. indifference point, 0s delay1.11.21.5-0.4-0.91.01.11.2-1.21.21.2-1.2-1.21.1-0.81.21.2
Delay disc. indifference point, 16s delay2.12.23.0-1.0-1.11.31.71.4-1.41.71.5-1.5-1.61.6-1.51.61.6
Delay disc. indifference point, 2s delay0.10.10.20.5-0.50.40.20.4-0.30.10.3-0.1-0.30.2-0.40.30.3
Delay disc. indifference point, 24s delay0.50.50.6-0.4-0.60.70.80.7-0.70.80.7-0.6-0.70.7-0.70.70.7
Delay disc. indifference point, 4s delay1.81.92.5-0.6-1.01.21.51.4-1.41.51.5-1.6-1.61.4-1.21.61.6
Delay disc. indifference point, 8s delay0.20.21.0-1.00.20.00.50.2-0.40.50.5-0.8-0.50.4-0.10.50.5
Indifference point function ln k1.01.42.0-0.11.3-1.3-1.1-1.41.4-1.1-1.31.21.2-1.11.0-1.1-1.1
Indifference point function log k1.01.42.0-0.11.3-1.3-1.1-1.41.4-1.1-1.31.21.2-1.11.0-1.1-1.1
Patch foraging total patch changes 0 sec0.91.52.10.11.1-1.2-1.4-1.31.3-1.2-1.31.31.4-1.21.1-1.3-1.3
Patch foraging total patch changes 12 sec0.10.10.20.5-0.50.40.10.4-0.30.10.3-0.2-0.20.3-0.20.20.2
Patch foraging total patch changes 18 sec0.10.10.1-0.20.2-0.2-0.4-0.20.2-0.3-0.30.20.3-0.20.3-0.2-0.2
Patch foraging total patch changes 24 sec0.60.71.40.80.5-0.7-1.2-0.70.7-1.1-0.80.70.9-0.90.9-0.9-0.9
Patch foraging total patch changes 6 sec0.10.10.4-0.10.4-0.4-0.5-0.30.3-0.4-0.30.10.4-0.20.7-0.3-0.3
Patch foraging time to switch 0 sec1.01.62.60.2-1.61.61.41.4-1.31.31.1-0.7-1.21.2-1.61.11.1
Patch foraging water rate 0 sec1.62.64.6-0.82.1-2.0-1.5-1.91.8-1.4-1.61.11.6-1.61.8-1.5-1.5
Patch foraging water rate 12 sec4.46.78.80.03.0-3.0-2.8-2.92.8-2.7-2.62.12.6-2.62.8-2.3-2.3
Patch foraging water rate 18 sec0.60.81.0-0.11.0-1.0-0.8-1.01.0-1.0-0.90.81.0-1.00.9-0.8-0.8
Patch foraging water rate 24 sec0.60.81.50.90.6-0.8-1.2-0.70.8-1.1-0.80.80.9-1.01.0-0.8-0.8
Patch foraging water rate 6 sec1.11.62.40.31.5-1.5-1.4-1.31.3-1.5-1.20.81.2-1.21.6-1.0-1.0
Seeking ratio, delayed vs. immediate footshock0.30.40.9-0.90.9-0.9-0.4-0.70.6-0.6-0.50.20.5-0.50.8-0.4-0.4
Distance traveled before self-admin0.00.00.1-0.30.10.00.2-0.00.00.3-0.10.0-0.10.1-0.1-0.1-0.1
Distance traveled after self-admin1.92.12.8-0.31.6-1.5-1.3-1.71.6-1.2-1.61.51.6-1.51.2-1.6-1.6
Extensor digitorum longus weight1.97.622.3-4.54.7-3.9-1.3-3.22.6-1.5-2.10.31.7-1.73.3-1.7-1.7
Bone: elastic displacement0.10.10.3-0.40.2-0.10.20.1-0.20.00.3-0.6-0.40.40.10.30.3
Bone: elastic work1.11.42.2-1.3-0.60.81.41.0-1.11.11.3-1.5-1.41.4-0.91.31.3
Bone: endosteal estimation1.02.14.5-2.02.1-1.8-1.0-1.71.5-1.0-1.40.71.2-1.21.5-1.2-1.2
Bone: endosteal perimeter0.71.59.7-3.12.0-1.5-0.0-1.20.9-0.2-0.7-0.20.4-0.41.0-0.5-0.5
Epididymis fat weight0.30.71.00.80.6-0.7-1.0-0.70.7-0.8-0.80.70.9-0.90.8-0.9-0.9
Delta time in closed arm before/after self-admin0.10.10.5-0.70.2-0.10.2-0.0-0.00.10.1-0.3-0.10.20.00.10.1
Delta time in open arm before/after self-admin0.50.54.12.0-0.70.3-0.70.00.2-0.5-0.41.00.4-0.4-0.1-0.5-0.5
Diff in mean of infusions in LGA sessions1.01.22.8-1.7-0.20.51.20.8-0.91.01.1-1.6-1.21.1-0.51.11.1
Delay discount exponential model param0.90.91.41.00.4-0.6-1.1-0.80.9-1.1-1.01.21.1-0.90.8-1.1-1.1
Extinction: sum of active levers before priming1.01.01.91.40.1-0.4-1.2-0.70.8-0.9-1.01.41.1-1.00.5-1.3-1.3
Active lever presses in extinction session 60.00.00.10.10.0-0.1-0.2-0.10.1-0.3-0.10.10.1-0.00.2-0.1-0.1
Bone: final force0.20.32.6-1.60.4-0.10.6-0.1-0.10.50.2-0.5-0.30.3-0.30.30.3
Bone: final moment0.20.42.2-1.50.10.20.90.2-0.30.80.4-0.5-0.50.5-0.60.50.5
Food consumed during 24 hour testing period1.92.32.80.01.5-1.5-1.7-1.61.6-1.7-1.61.51.5-1.51.4-1.5-1.5
Glucose0.71.11.70.41.1-1.2-1.2-1.11.1-1.3-1.00.81.0-1.11.2-0.9-0.9
Heart weight0.71.03.9-2.00.20.21.20.5-0.70.90.9-1.4-1.11.1-0.41.01.0
Delay discount hyperbolic model param0.80.81.10.80.5-0.7-1.0-0.80.9-1.0-1.01.11.0-0.90.8-1.0-1.0
Intermittent access intake day 1-15 change1.71.74.62.10.2-0.6-1.5-0.91.1-1.5-1.21.71.4-1.50.8-1.2-1.2
Intermittent access intake escalation1.71.75.12.30.1-0.5-1.5-0.81.0-1.5-1.21.71.4-1.50.8-1.2-1.2
Intermittent access intake escalation 21.11.11.61.10.5-0.7-1.2-0.91.0-1.2-1.11.21.2-1.30.8-1.0-1.0
Intermitt. access day 1 inactive lever presses0.20.21.51.2-0.60.4-0.10.2-0.1-0.00.10.3-0.00.0-0.5-0.1-0.1
Intermitt. access day 15 inactive lever presses0.80.91.4-0.3-0.50.71.10.9-1.00.91.0-1.2-1.00.9-0.81.11.1
Intermitt. access escalation Index0.40.42.9-1.71.0-0.60.2-0.40.20.2-0.1-0.5-0.10.10.4-0.0-0.0
Intermittent access day 1 total infusions0.10.21.01.0-0.60.5-0.10.2-0.10.0-0.00.5-0.0-0.1-0.6-0.0-0.0
Intermittent access day 15 total infusions0.50.64.22.0-0.70.3-0.7-0.10.3-0.6-0.51.20.6-0.7-0.3-0.5-0.5
Intermittent access terminal intake (last 3 days)0.30.31.21.1-1.00.80.20.5-0.40.10.30.3-0.20.1-0.80.30.3
Intermittent access total infusions1.11.24.52.1-0.2-0.2-1.2-0.60.8-1.1-1.01.71.1-1.10.2-1.0-1.0
Intermittent access day 1 locomotion0.50.51.41.0-1.21.00.40.8-0.60.50.50.1-0.50.5-1.00.40.4
Intermittent access day 15 total locomotion0.30.30.90.7-0.90.80.40.6-0.50.30.40.0-0.40.3-1.00.40.4
Intermittent access total locomotion0.30.30.70.80.1-0.3-0.7-0.50.5-0.6-0.60.90.6-0.60.2-0.6-0.6
Intermittent access standard deviation0.50.63.01.7-0.40.1-0.8-0.30.4-0.7-0.61.10.7-0.7-0.1-0.7-0.7
Left kidney weight0.72.05.5-1.92.3-2.0-0.8-1.71.5-1.0-1.20.41.0-1.11.5-1.0-1.0
Right kidney weight0.30.83.7-1.91.7-1.3-0.1-0.90.7-0.2-0.5-0.40.3-0.41.1-0.3-0.3
Cocaine induced anxiety0.50.60.7-0.2-0.80.80.80.8-0.80.80.8-0.7-0.80.8-0.70.80.8
Post-drug Anxiety0.80.91.90.7-1.41.20.71.2-1.10.81.0-0.7-0.90.9-0.80.80.8
Baseline Anxiety0.10.10.80.9-0.30.2-0.20.1-0.1-0.20.00.10.1-0.10.1-0.1-0.1
Tail length0.61.82.70.70.9-1.1-1.7-1.21.2-1.5-1.41.41.5-1.51.5-1.5-1.5
Length with tail0.10.41.9-1.41.2-0.9-0.1-0.70.5-0.1-0.4-0.20.3-0.20.8-0.3-0.3
Length without tail0.71.57.1-2.70.8-0.11.50.2-0.51.30.9-1.7-1.11.2-0.61.21.2
Times rat made contact with spout0.10.20.60.8-0.1-0.1-0.5-0.20.3-0.7-0.30.50.3-0.30.2-0.3-0.3
Lifetime Intake0.70.83.82.0-0.40.0-1.0-0.40.6-0.9-0.71.40.8-0.9-0.0-0.8-0.8
Liver weight, left2.13.44.40.51.9-2.0-2.0-1.91.9-2.1-1.91.61.8-1.82.1-1.9-1.9
Liver weight, right1.62.74.4-0.62.1-2.0-1.5-1.81.7-1.6-1.61.11.6-1.52.0-1.6-1.6
Locomotor activity1.42.25.8-2.22.4-2.0-0.9-1.81.6-1.1-1.30.51.1-1.01.6-1.0-1.0
Locomotor testing distance1.11.84.1-1.22.0-1.8-1.1-1.61.5-1.3-1.20.71.0-0.91.4-1.0-1.0
Locomotor testing rearing0.40.61.6-0.51.3-1.1-0.7-0.90.8-0.7-0.60.10.5-0.41.1-0.5-0.5
Locomotion in novel chamber0.30.41.00.6-1.00.90.40.7-0.60.20.5-0.0-0.40.5-0.90.50.5
Locomotion in novel chamber post-restriction0.60.71.0-0.6-0.60.71.00.8-0.91.00.9-1.0-0.91.0-0.70.90.9
Fecal boli incidents, locomotor time 10.60.71.1-0.3-0.60.81.10.8-0.91.00.9-0.9-0.80.9-0.80.80.8
Change in fecal boli incidents, locomotor task2.22.12.60.41.4-1.5-1.6-1.61.6-1.5-1.61.51.5-1.51.2-1.5-1.5
Time >=10cm from walls, locomotor time 10.30.30.7-0.8-0.10.20.70.3-0.40.70.5-0.7-0.60.5-0.40.60.6
Bouts of movement, locomotor time 10.20.20.4-0.30.6-0.5-0.4-0.50.4-0.5-0.40.20.5-0.50.5-0.4-0.4
Total resting periods, locomotor time 10.20.20.30.00.5-0.5-0.4-0.50.4-0.5-0.40.30.5-0.50.5-0.4-0.4
Rest time, locomotor task time 10.00.00.10.2-0.10.20.10.0-0.00.1-0.10.20.1-0.1-0.3-0.1-0.1
Distance moved, locomotor task time 10.10.10.40.6-0.1-0.0-0.4-0.00.1-0.1-0.10.20.2-0.10.2-0.3-0.3
Vertical activity count, locomotor time 10.10.10.3-0.2-0.30.30.20.4-0.40.50.4-0.5-0.30.5-0.20.40.4
Time >=10cm from walls, locomotor time 20.00.00.1-0.30.1-0.0-0.00.0-0.00.10.1-0.1-0.1-0.0-0.10.10.1
Bouts of movement, locomotor time 20.90.91.6-0.41.2-1.2-1.0-1.11.0-1.0-0.90.61.0-1.01.3-0.9-0.9
Total resting periods, locomotor time 21.31.42.1-0.31.3-1.4-1.2-1.31.2-1.2-1.20.91.2-1.21.4-1.1-1.1
Rest time, locomotor task time 20.00.00.10.3-0.40.30.10.1-0.10.2-0.00.20.10.1-0.3-0.2-0.2
Distance moved, locomotor task time 20.30.40.70.60.4-0.5-0.9-0.50.5-0.6-0.50.50.6-0.70.6-0.7-0.7
Vertical activity count, locomotor time 20.10.10.70.9-0.40.2-0.50.00.1-0.3-0.20.50.3-0.3-0.0-0.3-0.3
Light reinforcement 10.50.95.4-2.31.7-1.20.0-0.80.50.0-0.1-0.8-0.10.21.0-0.0-0.0
Light reinforcement 20.10.10.40.6-0.60.50.10.3-0.20.10.20.1-0.30.3-0.6-0.0-0.0
Bone: marrow area1.02.14.5-2.12.1-1.8-0.9-1.71.5-0.9-1.30.71.2-1.21.5-1.2-1.2
Bone: maximum diameter0.81.43.2-1.81.8-1.5-0.7-1.51.3-0.6-1.10.71.0-1.00.9-1.0-1.0
Bone: maximum force0.30.54.3-2.10.5-0.10.8-0.0-0.10.80.3-0.7-0.40.4-0.30.40.4
Bone: maximum moment0.30.63.7-1.90.20.11.00.2-0.31.00.4-0.7-0.60.6-0.60.50.5
Mean time between licks in bursts0.40.60.80.5-0.80.70.60.9-0.80.50.9-0.9-0.80.7-0.50.80.8
Mean num. licks in bursts0.20.31.0-0.81.0-0.8-0.2-0.70.6-0.4-0.50.10.3-0.30.5-0.3-0.3
Cd content in liver0.80.91.5-1.1-0.50.61.10.9-0.90.81.0-1.2-1.01.1-0.51.01.0
Co content in liver1.82.13.5-1.2-0.71.01.71.3-1.51.51.5-1.9-1.61.7-1.01.71.7
Cu content in liver0.60.72.5-1.60.00.31.10.5-0.70.90.8-1.2-0.90.9-0.40.80.8
Fe content in liver0.60.71.51.1-0.2-0.1-1.0-0.40.6-0.7-0.81.20.9-1.00.4-1.1-1.1
K content in liver0.20.20.9-0.70.9-0.7-0.1-0.60.4-0.1-0.3-0.10.3-0.20.5-0.3-0.3
Mg content in liver0.60.63.4-1.81.4-1.0-0.0-0.70.5-0.0-0.3-0.40.2-0.20.8-0.3-0.3
Mn content in liver0.30.41.4-1.2-0.10.40.80.3-0.40.80.5-0.5-0.50.5-0.70.40.4
Na content in liver1.31.32.0-0.31.4-1.3-1.1-1.31.2-0.9-1.20.81.2-1.21.2-1.3-1.3
Rb content in liver1.92.43.1-0.11.8-1.7-1.5-1.71.7-1.5-1.61.31.6-1.61.7-1.6-1.6
Se content in liver0.10.10.40.6-0.40.3-0.20.00.1-0.2-0.20.60.3-0.3-0.2-0.4-0.4
Sr content in liver0.40.40.7-0.3-0.40.50.70.7-0.70.80.7-0.8-0.70.7-0.30.70.7
Zn content in liver2.93.24.6-1.0-1.31.52.11.7-1.81.71.9-2.0-2.12.1-1.61.91.9
Bone: minimum diameter0.71.33.2-1.8-0.50.81.50.8-0.91.41.0-1.1-1.21.1-1.21.11.1
Time in familiar zone, hab. session 10.60.60.9-0.9-0.30.50.90.6-0.71.00.8-0.9-0.80.8-0.60.70.7
Time in novel zone, hab. session 10.30.31.11.1-0.1-0.1-0.7-0.30.4-0.7-0.40.80.5-0.50.1-0.5-0.5
Total zone transitions, hab. session 10.70.93.01.70.1-0.4-1.3-0.60.7-1.1-0.81.10.9-0.90.7-1.0-1.0
Total locomotion distance, hab. session 10.40.61.31.10.3-0.6-0.9-0.50.6-1.0-0.70.80.7-0.70.8-0.7-0.7
Locomotion velocity, hab. session 10.50.81.31.00.6-0.8-1.0-0.70.8-1.1-0.80.80.8-0.81.0-0.8-0.8
Time in familiar zone, hab. session 20.20.20.80.90.1-0.3-0.7-0.30.4-0.6-0.40.50.4-0.40.4-0.4-0.4
Time in novel zone, hab. session 20.10.10.3-0.2-0.20.30.40.2-0.20.20.2-0.1-0.20.3-0.50.30.3
Total zone transitions, hab. session 20.20.20.8-0.40.10.00.30.3-0.40.20.5-0.9-0.50.50.20.60.6
Total locomotion distance, hab. session 20.40.51.7-0.80.2-0.00.70.4-0.60.40.7-1.3-0.80.80.20.90.9
Locomotion velocity, hab. session 20.50.61.8-0.8-0.00.20.80.6-0.70.60.9-1.3-0.90.9-0.01.01.0
Novel to familiar place preference ratio0.30.32.3-1.50.5-0.20.6-0.0-0.10.60.2-0.6-0.30.4-0.00.30.3
Novelty place preference0.30.32.3-1.50.5-0.20.6-0.0-0.10.60.2-0.6-0.30.4-0.00.30.3
Time in novel zone, NPP test0.20.21.7-1.30.7-0.40.3-0.30.10.3-0.0-0.4-0.10.10.10.10.1
Total zone transitions, NPP test0.10.10.4-0.10.5-0.5-0.4-0.30.2-0.4-0.2-0.10.2-0.10.7-0.1-0.1
Total locomotion distance, NPP test0.40.51.20.20.8-0.9-0.8-0.70.7-0.8-0.60.30.6-0.71.1-0.6-0.6
Locomotion velocity, NPP test0.30.40.90.40.6-0.7-0.8-0.50.6-0.8-0.50.40.6-0.61.0-0.6-0.6
Intraocular pressure0.00.00.10.10.2-0.2-0.0-0.10.1-0.1-0.1-0.00.1-0.10.3-0.1-0.1
Delta distance traveled before/after self-admin2.52.73.50.01.7-1.8-1.7-1.81.8-1.9-1.71.51.7-1.71.6-1.6-1.6
Delta ambulatory time before/after self-admin1.41.52.20.11.2-1.3-1.3-1.41.4-1.5-1.31.31.4-1.41.0-1.2-1.2
Parametrial fat weight1.02.03.31.80.5-0.9-1.8-1.11.2-1.6-1.41.71.4-1.51.2-1.6-1.6
Pavlov. Cond. lever latency0.60.71.71.20.2-0.4-0.9-0.70.8-1.3-0.81.20.7-0.70.3-0.8-0.8
Pavlov. Cond. magazine entry latency11.414.719.5-2.8-2.73.34.43.8-4.04.34.0-4.4-4.14.1-3.24.04.0
Pavlov. Cond. change in total contacts3.63.85.8-1.6-1.21.52.31.8-2.02.32.1-2.4-2.12.1-1.42.02.0
Pavlov. Cond. index score4.76.08.3-1.6-1.92.22.82.5-2.62.92.6-2.8-2.52.5-1.92.52.5
Pavlov. Cond. latency score3.14.05.9-1.4-1.41.72.22.0-2.12.42.1-2.4-2.12.1-1.42.02.0
Pavlov. Cond. lever contacts1.51.83.2-1.3-0.81.01.51.2-1.41.81.4-1.7-1.31.3-0.91.31.3
Pavlov. Cond. magazine entry number9.311.615.32.12.7-3.1-3.9-3.43.6-3.8-3.63.73.6-3.62.9-3.6-3.6
Pavlov. Cond. intertrial magazine entries2.42.94.41.61.1-1.4-2.1-1.51.6-1.9-1.71.81.8-1.81.7-1.7-1.7
Pavlov. Cond. lever-magazine prob. diff.4.75.98.3-1.8-1.72.12.82.4-2.52.92.6-2.9-2.52.5-1.82.52.5
Pavlov. Cond. response bias7.89.413.0-2.4-2.12.63.63.0-3.13.63.2-3.5-3.23.2-2.53.23.2
Pavlov. Cond. lever latency1.21.62.10.01.2-1.2-1.4-1.31.4-1.4-1.31.31.3-1.31.2-1.3-1.3
Pavlov. Cond. magazine entry latency1.21.43.31.5-1.81.60.81.4-1.30.81.1-0.5-1.01.0-1.31.01.0
Pavlov. Cond. change in total contacts0.60.81.00.6-1.01.00.81.0-1.00.90.9-0.8-0.90.8-0.80.90.9
Pavlov. Cond. index score0.91.11.50.7-1.21.21.01.2-1.21.01.1-0.9-1.01.0-1.01.01.0
Pavlov. Cond. latency score0.50.71.00.7-1.00.90.80.9-0.90.80.8-0.7-0.80.8-0.80.80.8
Pavlov. Cond. lever contacts0.91.31.70.0-1.01.11.31.2-1.21.31.2-1.2-1.21.2-1.01.21.2
Pavlov. Cond. magazine entry number1.01.23.0-1.41.7-1.5-0.8-1.31.2-0.8-1.00.50.9-0.91.2-0.9-0.9
Pavlov. Cond. intertrial magazine entries0.81.11.50.21.0-1.1-1.2-1.11.1-1.1-1.11.01.0-1.00.9-1.1-1.1
Pavlov. Cond. lever-magazine prob. diff.1.11.41.90.7-1.41.31.11.4-1.31.11.2-1.0-1.21.2-1.21.21.2
Pavlov. Cond. response bias2.43.33.90.1-1.81.82.02.0-2.01.81.9-1.8-1.91.9-1.71.91.9
Time in closed arm before self-admin1.31.51.9-0.2-1.11.21.31.3-1.31.41.3-1.2-1.21.1-1.21.31.3
Time in closed arm after self-admin0.00.00.1-0.2-0.10.20.20.2-0.20.20.3-0.3-0.20.2-0.20.30.3
Time in open arm before self-admin1.31.42.5-1.01.6-1.4-0.9-1.41.3-1.1-1.20.91.1-1.11.2-1.1-1.1
Time in open arm after self-admin0.80.81.60.90.4-0.6-1.0-0.80.9-1.0-1.01.30.9-0.90.5-1.1-1.1
Bone: periosteal estimation0.61.23.5-1.91.6-1.3-0.5-1.31.1-0.6-1.00.60.8-0.80.8-0.8-0.8
Bone: periosteal perimeter0.61.03.5-1.91.6-1.3-0.4-1.21.0-0.4-0.90.40.7-0.70.8-0.8-0.8
Bone: post-yield work0.00.10.4-0.70.4-0.20.2-0.20.10.2-0.1-0.10.1-0.10.2-0.1-0.1
Progressive ratio test 1 active lever presses0.70.81.51.20.3-0.5-1.0-0.80.9-1.0-0.91.20.9-0.90.5-0.9-0.9
Progressive ratio test 1 breakpoint0.30.31.51.2-0.1-0.1-0.6-0.30.4-0.6-0.50.90.5-0.50.1-0.5-0.5
Progressive ratio test 1 inactive lever presses1.61.76.52.5-0.2-0.3-1.6-0.71.0-1.3-1.11.91.2-1.30.4-1.3-1.3
Progressive ratio test 2 active lever presses0.20.30.50.20.4-0.5-0.5-0.50.6-0.6-0.50.70.5-0.50.3-0.5-0.5
Progressive ratio test 2 breakpoint0.60.71.00.30.7-0.8-0.9-0.90.9-0.9-0.91.00.8-0.90.6-0.8-0.8
Progressive ratio test 2 inactive lever presses0.30.30.80.9-0.90.70.40.5-0.40.20.40.1-0.40.3-0.90.40.4
Incentive Sensitization - Responses0.20.21.5-1.20.5-0.30.3-0.20.10.00.1-0.3-0.20.10.00.30.3
Incentive Sensitization - Breakpoint0.20.21.3-1.20.4-0.20.4-0.0-0.10.10.2-0.4-0.30.2-0.10.40.4
Sum of active levers in priming session hrs 5-60.20.20.30.40.2-0.2-0.4-0.40.4-0.3-0.50.60.4-0.40.2-0.5-0.5
Progressive ratio3.43.95.1-1.1-1.51.82.22.0-2.12.32.1-2.2-2.12.2-1.72.02.0
Food seeking constrained by brief footshock2.63.24.40.61.6-1.8-2.1-1.81.8-1.8-1.81.71.9-1.81.9-2.0-2.0
Seeking ratio, punishment vs. effort7.79.411.00.63.0-3.2-3.3-3.33.3-3.2-3.22.93.2-3.23.1-3.1-3.1
Retroperitoneal fat weight0.20.51.00.50.6-0.7-1.0-0.70.7-0.9-0.70.60.6-0.70.8-0.7-0.7
Reaction time number correct0.81.12.4-0.71.5-1.4-1.0-1.21.1-1.0-0.90.50.9-1.11.3-0.9-0.9
Reaction time mean minus median0.30.41.41.2-0.30.0-0.7-0.30.4-0.5-0.61.00.7-0.60.0-0.8-0.8
Reaction time mean minus median AUC0.70.93.61.9-0.50.1-1.1-0.30.6-0.6-0.81.50.9-0.80.0-1.1-1.1
Reaction time num false alarms0.20.31.11.0-0.20.0-0.5-0.20.3-0.5-0.50.80.6-0.60.1-0.4-0.4
Reaction time num false alarms AUC0.91.22.21.00.5-0.7-1.2-1.01.1-1.2-1.21.51.2-1.30.8-1.2-1.2
Reaction time trials correct on left0.81.12.4-0.71.5-1.4-1.0-1.21.1-1.0-0.90.50.9-1.11.3-0.9-0.9
Reaction time trials on left0.91.22.5-0.61.6-1.5-1.0-1.31.2-1.0-1.00.51.0-1.11.4-1.0-1.0
Reaction time mean0.71.04.32.1-1.81.50.31.0-0.80.50.50.3-0.40.4-1.30.20.2
Reaction time mean AUC0.60.83.51.9-1.61.30.10.9-0.60.40.30.4-0.20.2-1.1-0.0-0.0
Median of all reaction times1.21.64.61.9-2.11.80.81.4-1.20.81.0-0.1-0.80.8-1.60.70.7
Reaction time omissions0.50.71.0-0.00.7-0.7-1.0-0.80.8-0.7-0.80.70.9-1.00.8-1.0-1.0
Reaction time false alarm rate0.20.32.11.4-0.60.3-0.4-0.00.2-0.4-0.40.90.5-0.5-0.1-0.4-0.4
Reaction time premature initiation rate0.30.41.1-0.31.1-1.0-0.6-0.80.7-0.4-0.60.30.5-0.41.0-0.5-0.5
Reaction time premature initiations0.81.12.7-0.71.7-1.5-0.9-1.31.2-0.7-1.00.40.8-0.81.4-0.9-0.9
Std. dev. reaction times0.40.53.71.9-1.00.7-0.40.3-0.1-0.1-0.20.80.3-0.3-0.5-0.5-0.5
Reaction time trials completed0.91.22.5-0.61.6-1.5-1.0-1.31.2-1.0-1.00.51.0-1.11.4-1.0-1.0
Reaction time trials AUC0.71.02.1-0.61.5-1.3-0.9-1.21.1-1.0-0.90.40.8-1.01.3-0.9-0.9
Run reversals in cocaine runway, females0.60.50.80.20.7-0.7-0.7-0.80.8-0.8-0.80.70.9-0.80.7-0.8-0.8
Run reversals in cocaine runway, males0.70.71.10.80.7-0.8-1.0-0.80.8-0.7-0.90.81.0-0.90.9-0.9-0.9
Latency to leave start box in cocaine runway0.90.92.2-1.11.5-1.3-0.6-1.11.0-0.6-0.90.40.7-0.71.1-0.9-0.9
Latency to leave start box in cocaine runway, F0.70.81.1-0.21.1-1.0-0.9-1.00.9-0.7-0.90.70.9-1.01.1-1.0-1.0
Latency to leave start box in cocaine runway, M0.50.42.6-1.61.2-0.90.2-0.70.5-0.1-0.3-0.20.1-0.00.6-0.2-0.2
Std. dev. time between licks in bursts0.81.02.5-1.30.00.31.10.7-0.80.91.1-1.6-1.11.1-0.31.11.1
Total sessions with >9 infusions1.11.22.91.70.2-0.5-1.3-0.81.0-1.2-1.11.61.1-1.20.5-1.1-1.1
Short access day 1 total inactive lever presses2.42.74.81.60.8-1.1-1.8-1.51.7-1.7-1.72.21.7-1.80.9-1.8-1.8
Short access day 10 total inactive lever presses0.60.72.81.7-0.1-0.2-1.0-0.50.6-0.8-0.71.10.8-0.90.3-0.9-0.9
Short access day 1 total infusions0.30.41.01.0-0.2-0.1-0.7-0.30.5-0.5-0.61.00.6-0.6-0.0-0.7-0.7
Short access day 10 total infusions0.50.63.11.8-0.40.1-0.8-0.20.4-0.6-0.61.10.6-0.7-0.2-0.6-0.6
Short access total infusions0.80.95.02.2-0.60.2-0.9-0.30.5-0.7-0.71.40.7-0.8-0.1-0.8-0.8
Short access day 1 locomotion0.10.10.30.40.1-0.2-0.5-0.30.3-0.3-0.30.50.3-0.30.1-0.5-0.5
Short access day 10 total locomotion1.01.11.50.90.7-0.8-1.2-1.01.1-1.1-1.11.21.1-1.10.7-1.2-1.2
Short access total locomotion0.40.42.51.6-0.50.2-0.6-0.10.3-0.4-0.40.90.4-0.4-0.2-0.6-0.6
One hour access (0.3 mA shock)0.00.00.10.10.00.0-0.0-0.10.10.0-0.10.20.0-0.0-0.2-0.2-0.2
Compulsive drug intake0.10.10.3-0.00.5-0.4-0.3-0.50.4-0.1-0.40.30.3-0.20.3-0.5-0.5
One hour access (shock baseline)0.00.10.20.3-0.50.40.10.2-0.2-0.00.10.1-0.1-0.0-0.40.10.1
Social response proportion1.21.33.1-1.7-0.30.61.50.8-0.91.31.0-1.2-1.21.3-0.91.11.1
Social responses0.00.10.6-0.70.1-0.00.20.0-0.10.30.1-0.2-0.20.2-0.00.10.1
Social time0.71.01.60.30.6-0.8-1.2-1.01.0-1.1-1.11.31.0-1.10.7-1.2-1.2
Soleus weight4.814.036.6-5.26.0-5.2-2.4-4.43.8-2.4-3.21.02.7-2.74.5-2.7-2.7
Bone: stiffness1.22.02.6-0.51.5-1.5-1.3-1.61.6-1.2-1.51.41.5-1.51.2-1.5-1.5
Tibialis anterior weight4.816.538.0-4.06.2-5.5-3.0-4.94.4-3.3-3.81.93.3-3.34.7-3.3-3.3
Time to tail flick, vehicle, before self-admin0.00.00.2-0.10.0-0.0-0.10.2-0.20.00.2-0.4-0.20.20.40.10.1
Time to tail flick, vehicle, after self-admin0.00.00.2-0.50.4-0.3-0.0-0.30.2-0.2-0.20.10.0-0.10.1-0.1-0.1
Time to tail flick, test, before self-admin3.73.65.1-0.9-1.51.72.21.9-2.02.02.0-2.0-2.12.0-1.72.12.1
Time to tail flick, test, after self-admin0.50.53.51.9-0.70.4-0.70.00.2-0.4-0.30.90.5-0.4-0.2-0.5-0.5
Delta time to tail flick, vehicle, before/after SA0.10.10.3-0.2-0.20.20.30.1-0.00.20.10.1-0.20.2-0.60.20.2
Delta time to tail flick, test, before/after SA2.82.54.11.70.7-1.0-2.0-1.41.5-1.7-1.62.01.7-1.71.0-1.8-1.8
Tibia length0.61.63.0-1.6-0.71.01.71.0-1.11.61.1-1.1-1.21.2-1.31.41.4
Ambulatory time before self-admin0.10.10.40.1-0.50.50.40.4-0.30.60.2-0.1-0.30.3-0.50.20.2
Ambulatory time after self-admin1.31.42.0-0.11.1-1.1-1.1-1.31.4-1.1-1.41.41.3-1.30.8-1.3-1.3
Bone: tissue strength0.50.51.21.0-1.10.90.50.8-0.60.40.6-0.1-0.50.6-0.80.50.5
Total heroin consumption1.41.62.3-0.41.5-1.5-1.3-1.41.3-1.2-1.30.91.2-1.21.5-1.3-1.3
Bone: trabecular number0.50.91.40.4-1.21.10.91.1-1.00.80.9-0.7-0.90.8-1.00.90.9
Bone: trabecular spacing0.00.10.10.20.0-0.1-0.3-0.20.2-0.0-0.30.40.3-0.30.1-0.3-0.3
Bone: trabecular thickness0.00.00.20.3-0.10.10.0-0.10.1-0.2-0.10.3-0.0-0.1-0.4-0.0-0.0
Bone: trabecular tissue density2.73.87.8-1.72.8-2.4-1.5-2.42.2-1.3-2.01.31.9-1.91.7-1.7-1.7
Water consumed over 24 hours0.10.10.20.3-0.50.40.10.3-0.20.00.20.1-0.20.2-0.40.20.2
Number of responses in last shaping day0.00.00.30.6-0.20.1-0.1-0.00.1-0.1-0.10.30.1-0.1-0.1-0.1-0.1